1月18日，广州医科大学附属第一医院/呼吸疾病国家重点实验室赵金存教授团队与香港大学Malik Peiris教授，广州海关技术中心国家生物安全检测重点实验室（P3实验室）合作，在PNAS杂志在线发表了题为Mouse models susceptible to HCoV-229E and HCoV-NL63 and cross protection from challenge with SARS-CoV-2的研究成果。作者利用表达229E和NL63受体的腺病毒载体，滴鼻转导不同遗传背景小鼠，快速构建229E和NL63易感小鼠模型。此动物模型可应用于广谱抗病毒药物和疫苗评估，并且在体内水平上阐明229E、NL63冠状病毒和新冠病毒之间存在交叉保护作用，为冠状病毒致病机制研究提供平台。
呼吸疾病国家重点实验室赵金存教授、肇静娴教授，香港大学Malik Peiris教授为本文共同通讯作者，广州医科大学附属第一医院/呼吸疾病国家重点实验室刘冬兰博士、陈春可博士、陈锭彬博士、朱爱如博士、李芳博士、庄珍博士、香港中文大学莫家斌教授（Chris Ka Pun Mok）、广州海关技术中心国家生物安全检测重点实验室（P3实验室）戴俊博士、李小波博士、以及广州市妇女儿童医疗中心金颖康博士为本文并列第一作者。该研究得到了科技部和国自然等项目的资助。
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