Stuart H.   Orkin，美国哈佛医学院David G. Nathan特聘儿科教授、霍华德·休斯医学研究所研究员

获奖原因：对血液病遗传基础展开基础性研究，以及推进镰状细胞贫血症和β－地中海贫血症的基因治疗

https://news.sciencenet.cn/htmlnews/2022/9/486641.shtm

https://pubmed.ncbi.nlm.nih.gov/34779027/

No abstract available

Conflict of interest statement

Immacolata Andolfo and Achille Iolascon declare no conflict of interest. Seth L. Alper is a consultant for and receives research support from Quest Diagnostics, Inc.

Figures

FIGURE 1 

Schematic representation of PIEZO1 and…

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References

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1. Coste B, Mathur J, Schmidt M, et al. Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels. Science. 2010;330:55‐60. - PMC - PubMed

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MeSH terms

• Anemia, Sickle Cell / metabolism*

• Animals

• Calcium / metabolism

• Hematology

• Humans

• Ion Channels / metabolism

• Nobel Prize

• TRPV Cation Channels / metabolism

• Temperature

• Thermosensing*

• Touch*

Substances

• Ion Channels

• PIEZO1 protein, human

• PIEZO2 protein, human

• TRPV Cation Channels

• TRPV1 protein, human

• Calcium

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