氢分子医学分享 http://blog.sciencenet.cn/u/孙学军 对氢气生物学效应感兴趣者。可合作研究:sunxjk@hotmail.com 微信 hydrogen_thinker

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氢气治疗多器官功能衰竭

已有 7522 次阅读 2010-4-1 12:47 |个人分类:呼吸氢气|系统分类:论文交流|关键词:学者| 氢气

多器官功能衰竭(MOF)是一种病因繁多、发病机制复杂、病死率极高的临床综合征。MOF是指机体在经受严重损害(如严重疾病、外伤、手术、感染、休克等)后,发生两个或两个以上器官功能障碍,甚至功能衰竭的综合征。MODS是与应激密切相关的急性全身性器官功能损害。MOF的发病机理非常复杂,多数观点认为,尽管病因多种多样,导致MOF发生发展的机制是共同的。当机体经受打击后,发生全身性自我破坏性炎性反应过程,称为全身性炎性反应综合征(Systemic Inflammatory Response SyndromeSIRS)。在感染或无感染的情况下均可发生SIRSSIRS最终导致MOF治疗MOF的主要措施1.消除引起MOF的病因和诱因,治疗原发疾病。2.改善和维持组织充分氧合3.保护肝、肾功能4. 营养支持及代谢调理5. 合理应用抗生素。6. 抗氧化剂、自由基清除剂的应用7. 特异性治疗。

第四军医大学西京医院麻醉科去年曾经发表氢气治疗脓毒症的文章,这个报道是上次文章的基础上的进一步延伸。该研究采用酵母浸液腹腔注射诱导动物发生多器官功能衰竭,通过呼吸2%的氢气,发现能有效提高动物生存率,提高器官抗氧化能力,减轻血液和器官炎症反应指标。研究说明氢气呼吸能有效治疗脓毒症之多器官功能衰竭,是一篇不可多得的优秀研究。值得学习,不过有一点遗憾的是,本研究采用的研究指标中有关于形态学的研究,但没有提供相关照片,是比较遗憾,感觉数据中相对硬的指标不足。当然这不影响该论文的质量。

能在比较有影响力的休克杂志上发表,也算是该研究水平的一个说明。该课题组在氢气治疗系统炎症方面的研究在国际上领先其他小组。到目前为止,关于采用呼吸氢气治疗疾病的研究仍不足10篇,其中这个小组已经发表2篇。日本今年的学术年会中,日本氢气研究奠基人太田成男教授专门对他们的工作进行介绍,说明他们在氢气生物学效应研究方面处于领先地位。

Shock. 2010 Mar 23. [Epub ahead of print]

HYDROGEN GAS IMPROVES SURVIVAL RATE AND ORGAN DAMAGE IN ZYMOSAN-INDUCED GENERALIZED INFLAMMATION MODEL.

Xie K, Yu Y, Zhang Z, Liu W, Pei Y, Xiong L, Hou L, Wang G.

1Department of Anesthesiology, General Hospital of Tianjin Medical University, Tianjin 300052, P. R. China. 2Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, P. R. China. 3Department of Neurosurgery, Xijing Institute of Clinical Neuroscience, Xiing Hospital, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, P. R. China.

Sepsis/Multiple organ dysfunction syndrome (MODS) is the leading cause of death in critically ill patients. Recently, it has been suggested that hydrogen gas (H2) exerts a therapeutic antioxidant activity by selectively reducing hydroxyl radical (.OH, the most cytotoxic ROS). We have found that H2 inhalation significantly improved the survival rate and organ damage of septic mice with moderate or severe cecal ligation and puncture (CLP). In the present study, we investigated the effects of 2% H2 treatment on survival rate and organ damage in zymosan-induced generalized inflammation model. Here, we found that 2% H2 inhalation for 60 minutes starting at 1 and 6 hours after zymosan injection, respectively, significantly improved the 14-day survival rate of zymosan-challenged mice from 10% to 70%. Furthermore, zymosan-challenged mice showed significant multiple organ damage characterized by the increase of serum biochemical parameters (AST, ALT, BUN and Cr), as well as lung, liver and kidney histopathological scores at 24 hours after zymosan injection, which was significantly attenuated by 2% H2 treatment. In addition, we found that the beneficial effects of H2 treatment on zymosan-induced organ damage were associated with the decreased levels of oxidative product, increased activities of antioxidant enzyme as well as reduced levels of early and late proinflammatory cytokines in serum and tissues. In conclusion, this study provides evidence that H2 treatment protects against multiple organ damages in zymosan-induced generalized inflammation model, suggesting that the potential use of H2 as a therapeutic agent in the therapy of conditions associated with inflammation-related MODS.

PMID: 20351628 [PubMed - as supplied by publisher]

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