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M13病毒的神奇应用

已有 3733 次阅读 2014-11-23 13:10 |个人分类:评论|系统分类:海外观察|关键词:学者

最近听到一个韩国人Lee(http://leelab.berkeley.edu/)的报告,他们就用M13病毒蛋白可以形成螺旋直链结构的特性模拟collagen的特性。他们从美国卖火鸡的地方买了很多火鸡头,实际是免费的,因为美国人不吃鸡头,从鸡头里面提取collagen,发明collage的组织结构,然后用M13病毒蛋白形成的螺旋链合成类似结构的物质。下面这个联接的movie可以看到这种物质的神奇特性,如果你用手指轻压,机械力就会转化成电能,电能可以使手机屏幕电子屏显示数字。他们下一步打算把这个装置装在心脏起搏器上,心脏跳动的机械能可以自动给起搏器充电。中国就是缺少这种有点独特创新的研究,跟踪国外的东西太多,文章是很重要,但不应该是全部,创新的地方还是太少。

a, The M13 phage is ~880 nm in length and ~6.6 nm in diameter, is covered by ~2,700 pVIII coat proteins and has five copies each of pIII (grey lines) and pIX (black lines) proteins at either end. b, Side view of the electrostatic potential of M13 phage after bioengineered modification with four glutamate amino acids. The dipole moments generated by ten α-helical major coat proteins are directed from the N-terminus (blue) to the C-terminus (red). Yellow arrows indicate dipole direction. c, Vertical cross-sectional view of the electrostatic potential of M13 phage. The pVIII coat proteins assemble with five-fold rotational and two-fold screw symmetry. d, Side-view representation of the electrostatic potential of a single M13-phage pVIII coat protein. The pVIII coat protein has an ~20° tilt angle with respect to the phage long axis. The colours of the molecular surface indicate positive (red), neutral (white) and negative (blue) electrostatic potentials. Yellow arrows filled with two colours (red and blue) represent the dipole pointing from negative (blue) to positive (red) regions. e, Primary structure of the engineered major coat protein. Amino acids with positively and negatively charged side chains are labelled in red and blue, respectively. The engineered four-glutamate (4E) amino-acid sequence is underlined. Figure courtesy of Seung-Wuk Lee

https://www.youtube.com/watch?v=X93Xf8e4etA

https://www.youtube.com/watch?v=raTuXvvqdnU

http://www.realscience.us/2012/05/15/electricity-from-viruses-may-power-personal-devices/



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