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Jeffrey M. Friedman的论文被引用情况（2010年生理学或医学诺贝尔奖得主预测）
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美国纽约州洛克菲勒大学 分子遗传学实验室 教授兼美国马里兰州切维柴斯 研究员 Jeffrey M. Friedman
获奖原因
因发现调节食欲和新陈代谢的激素致轻素而获奖
colorado.edu [PDF]JM Friedman - Nature, 2000 - nature.com
Obesity has increased at an alarming rate in recent years and is now a worldwide public health
problem. In addition to suffering poor health and an increased risk of illnesses such as hypertension
and heart disease, obese people are often stigmatized socially. But major advances have ...
Cited by 483 - Related articles - BL Direct - All 15 versions
Obesity has increased at an alarming rate in recent years and is now a worldwide public health
problem. In addition to suffering poor health and an increased risk of illnesses such as hypertension
and heart disease, obese people are often stigmatized socially. But major advances have ...
Cited by 483 - Related articles - BL Direct - All 15 versions
[CITATION] A war on obesity, not the obese
Cited by 234 - Related articles - BL Direct - All 16 versions
nih.gov [HTML]… Feinstein, P Mombaerts, JM Friedman - Journal of Clinical …, 2001 - Am Soc Clin Investig
Animals with mutations in the leptin receptor (ObR) exhibit an obese phenotype that is indistinguishable
from that of leptin deficient ob/ob mice. ObR is expressed in many tissues, including brain, and
the relative importance of leptin's effects on central versus peripheral sites has not been ...
Cited by 264 - Related articles - BL Direct - All 11 versions
Animals with mutations in the leptin receptor (ObR) exhibit an obese phenotype that is indistinguishable
from that of leptin deficient ob/ob mice. ObR is expressed in many tissues, including brain, and
the relative importance of leptin's effects on central versus peripheral sites has not been ...
Cited by 264 - Related articles - BL Direct - All 11 versions
… , KM Carroll, JG Darvishzadeh, JI Lee, JM Friedman - 1996 - nature.com
... JI Lee * & JM Friedman *†. * Howard Hughes Medical Institute, and † Department of Molecular
Genetics, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA.
MUTATIONS in the mouse diabetes(db) gene result in obesity and diabetes in a syndrome ...
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... JI Lee * & JM Friedman *†. * Howard Hughes Medical Institute, and † Department of Molecular
Genetics, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA.
MUTATIONS in the mouse diabetes(db) gene result in obesity and diabetes in a syndrome ...
Cited by 1466 - Related articles - BL Direct - All 5 versions
unc.edu [PDF]JM Friedman - Nature medicine, 2004 - nature.com
Obese people, who are already subject to adverse health effects, are additionally victimized
by a social stigma predicated on the Hippocratic nostrum that weight can be controlled by
'deciding' to eat less and exercise more. This simplistic notion is at odds with substantial ...
Cited by 153 - Related articles - BL Direct - All 5 versions
Obese people, who are already subject to adverse health effects, are additionally victimized
by a social stigma predicated on the Hippocratic nostrum that weight can be controlled by
'deciding' to eat less and exercise more. This simplistic notion is at odds with substantial ...
Cited by 153 - Related articles - BL Direct - All 5 versions
134.243.5.70 [PDF]… Proenca, M Maffei, M Barone, L Leopold, JM Friedman … - Nature, 1994 - 134.243.5.70
... gene and its human homologue Yiying Zhang , Ricardo Proenca , Margherita Maffei , Marisa
Barone , Lori Leopold & Jeffrey M. Friedman * Howard Hughes ... Mutation of ob results in profound
obesity and type II diabetes as part of a syndrome that resembles morbid obesity in ...
Cited by 7894 - Related articles - BL Direct - All 20 versions
... gene and its human homologue Yiying Zhang , Ricardo Proenca , Margherita Maffei , Marisa
Barone , Lori Leopold & Jeffrey M. Friedman * Howard Hughes ... Mutation of ob results in profound
obesity and type II diabetes as part of a syndrome that resembles morbid obesity in ...
Cited by 7894 - Related articles - BL Direct - All 20 versions
… , M Maffei, H Wang, JM Friedman, PH Bennett, C … - Nature medicine, 1997 - nature.com
... Eric Ravussin 1, 4 , Richard E. Pratley 1 , Margherita Maffei 2 , Hong Wang 2, 3 , Jeffrey M.
Friedman 2, 3 , Peter H. Bennett 1 & ... These data indicate that relatively low plasma leptin
concentrations may play a role in the development of obesity in Pima Indians, a population prone ...
Cited by 190 - Related articles - BL Direct - All 4 versions
... Eric Ravussin 1, 4 , Richard E. Pratley 1 , Margherita Maffei 2 , Hong Wang 2, 3 , Jeffrey M.
Friedman 2, 3 , Peter H. Bennett 1 & ... These data indicate that relatively low plasma leptin
concentrations may play a role in the development of obesity in Pima Indians, a population prone ...
Cited by 190 - Related articles - BL Direct - All 4 versions
pnas.org [PDF]GE Truett, N Bahary, JM Friedman, … - Proceedings of the …, 1991 - National Acad Sciences
... 5. Leibel, RL, Bahary,N. & Friedman, JM (1990) in World Review of Nutrition Diet Genetic Variation
Nutrition, eds. ... DD, Michaelis, 0. E., IV, & Peterson,RG (1988) in New Models ofGenetically Obese
Ratsfor Studies in Diabetes, Heart Disease, and Complications of Obesity, eds. ...
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... 5. Leibel, RL, Bahary,N. & Friedman, JM (1990) in World Review of Nutrition Diet Genetic Variation
Nutrition, eds. ... DD, Michaelis, 0. E., IV, & Peterson,RG (1988) in New Models ofGenetically Obese
Ratsfor Studies in Diabetes, Heart Disease, and Complications of Obesity, eds. ...
Cited by 86 - Related articles - All 9 versions
pnas.org [HTML]… B Moon, E Connolly, JM Friedman - Proceedings of the …, 1998 - National Acad Sciences
A subset of obese humans has relatively low plasma levels of leptin. This finding has suggested
that in some cases abnormal regulation of the leptin gene in adipose tissue is etiologic in the
pathogenesis of the obese state. The possibility that a relative decrease in leptin ...
Cited by 77 - Related articles - BL Direct - All 12 versions
A subset of obese humans has relatively low plasma levels of leptin. This finding has suggested
that in some cases abnormal regulation of the leptin gene in adipose tissue is etiologic in the
pathogenesis of the obese state. The possibility that a relative decrease in leptin ...
Cited by 77 - Related articles - BL Direct - All 12 versions
… , J Ott, M Stoffel, JL Breslow, JM Friedman - Human …, 2000 - content.karger.com
Objectives: Obesity, type II diabetes, hypertension, and dyslipidemia are major causes of morbidity
and mortality throughout the world. Though these disorders often cluster in individuals and families
and are collectively known as syndrome X, the basis for this aggregation is not well ...
Cited by 63 - Related articles - BL Direct - All 5 versions
Objectives: Obesity, type II diabetes, hypertension, and dyslipidemia are major causes of morbidity
and mortality throughout the world. Though these disorders often cluster in individuals and families
and are collectively known as syndrome X, the basis for this aggregation is not well ...
Cited by 63 - Related articles - BL Direct - All 5 versions
[HTML] Physiological response to long-term peripheral and central leptin infusion in lean and obese mice
... the resistance of NZO and DIO mice to peripheral leptin could have important implications for
understanding the pathogenesis of human obesity. ... Abstract/FREE Full Text. ↵: Zhang Y,; Proenca
R,; Maffei M,; Barone M,; Leopold L,; Friedman JM. (1994) Nature (London) 372:425–432 ...
Cited by 618 - Related articles - BL Direct - All 15 versions
pnas.org [HTML]M Ishii, H Fei, JM Friedman - Proceedings of the National …, 2003 - National Acad Sciences
Gold-thioglucose (GTG) induces lesions in the ventromedial nucleus of the hypothalamus, resulting
in hyperphagia and obesity. To identify genes involved in the hypothalamic regulation of energy
homeostasis, we used a screen for genes that are dysregulated in GTG-induced obese ...
Cited by 58 - Related articles - BL Direct - All 11 versions
Gold-thioglucose (GTG) induces lesions in the ventromedial nucleus of the hypothalamus, resulting
in hyperphagia and obesity. To identify genes involved in the hypothalamic regulation of energy
homeostasis, we used a screen for genes that are dysregulated in GTG-induced obese ...
Cited by 58 - Related articles - BL Direct - All 11 versions
medvetande.dk [PDF]JM Friedman, JL Halaas - Nature, 1998 - nature.com
... | Article | PubMed | ISI | ChemPort |; Schneider, BS , Friedman, JM & Hirsch, J. in Brain Peptides
(eds Krieger, D., Martin, J. & Brownstien, M.) 251–280 (Wiley, USA, (1983)). Spiegelman, BM
& Flier, JS Adipogenesis and obesity: rounding out the big picture. ...
Cited by 2691 - Related articles - BL Direct - All 23 versions
... | Article | PubMed | ISI | ChemPort |; Schneider, BS , Friedman, JM & Hirsch, J. in Brain Peptides
(eds Krieger, D., Martin, J. & Brownstien, M.) 251–280 (Wiley, USA, (1983)). Spiegelman, BM
& Flier, JS Adipogenesis and obesity: rounding out the big picture. ...
Cited by 2691 - Related articles - BL Direct - All 23 versions
JM Friedman - Nutrition reviews, 1998 - interscience.wiley.com
... Amer J Physiol 1942;136:609-17 Coleman DL. Obese and diabetes: two mutant genes causing
diabetes-obesity syndromes in mice. Diabetologia 1978;14:141-8 Friedman JM, Leibel RL.
Tackling a weighty prob- lem. Cell 1992;69:217-20 Hervey GR. ...
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... Amer J Physiol 1942;136:609-17 Coleman DL. Obese and diabetes: two mutant genes causing
diabetes-obesity syndromes in mice. Diabetologia 1978;14:141-8 Friedman JM, Leibel RL.
Tackling a weighty prob- lem. Cell 1992;69:217-20 Hervey GR. ...
Cited by 257 - Related articles - BL Direct - All 6 versions
JM Friedman, RL Leibel, N Bahary - Mammalian Genome, 1991 - Springer
Abstract. Advances in molecular genetics have made it possible to clone mutant genes from
mammals. This capability should facilitate efforts to determine the ge- netic factors that control
food intake and body com- position. In order to identify these genetic factors, we have ...
Cited by 46 - Related articles - All 2 versions
Abstract. Advances in molecular genetics have made it possible to clone mutant genes from
mammals. This capability should facilitate efforts to determine the ge- netic factors that control
food intake and body com- position. In order to identify these genetic factors, we have ...
Cited by 46 - Related articles - All 2 versions
… , F Folli, L Benzi, S Cinti, JM Friedman, … - Journal of cellular …, 2002 - interscience.wiley.com
CHIARA CHIELLINI,1 ANNA BERTACCA,1 SILVIA E. NOVELLI,1 CEM Z. GOÈ RGUÈ N,2 ANNAMARIA
CICCARONE,1 ANTONIO GIORDANO,3 HAIYAN XU,2 ALEXANDER SOUKAS,4 MARIO
COSTA,5 DANIELE GANDINI,6 ROBERTO DIMITRI,6 PIETRO BOTTONE,6 PAOLO ...
Cited by 40 - Related articles - BL Direct - All 5 versions
CHIARA CHIELLINI,1 ANNA BERTACCA,1 SILVIA E. NOVELLI,1 CEM Z. GOÈ RGUÈ N,2 ANNAMARIA
CICCARONE,1 ANTONIO GIORDANO,3 HAIYAN XU,2 ALEXANDER SOUKAS,4 MARIO
COSTA,5 DANIELE GANDINI,6 ROBERTO DIMITRI,6 PIETRO BOTTONE,6 PAOLO ...
Cited by 40 - Related articles - BL Direct - All 5 versions
pnas.org [PDF]… , R Negrel, G Ailhaud, JM Friedman - Proceedings of the …, 1995 - National Acad Sciences
... GTG administered as a single dose causes obesity by inducing specific hypothalamic
lesions. ... NY Acad. Sci. 131, 559-582. 3. Zhang, Y., Proenca, P., Maffei,M., Barone, M.,
Leopold, L. & Friedman, JM (1994) Nature (London) 372, 425-432. ...
Cited by 269 - Related articles - BL Direct - All 12 versions
... GTG administered as a single dose causes obesity by inducing specific hypothalamic
lesions. ... NY Acad. Sci. 131, 559-582. 3. Zhang, Y., Proenca, P., Maffei,M., Barone, M.,
Leopold, L. & Friedman, JM (1994) Nature (London) 372, 425-432. ...
Cited by 269 - Related articles - BL Direct - All 12 versions
pnas.org [HTML]… , JL Breslow, M Stoffel, JM Friedman - Proceedings of the …, 2006 - National Acad Sciences
Obesity, diabetes, hypertension, and heart disease are highly heritable conditions that in aggregate
are the major causes of morbidity and mortality in the developed world and are growing problems
in developing countries. To map the causal genes, we conducted a population screen for ...
Cited by 38 - Related articles - BL Direct - All 10 versions
Obesity, diabetes, hypertension, and heart disease are highly heritable conditions that in aggregate
are the major causes of morbidity and mortality in the developed world and are growing problems
in developing countries. To map the causal genes, we conducted a population screen for ...
Cited by 38 - Related articles - BL Direct - All 10 versions
P Cohen, JM Ntambi, JM Friedman - Current drug targets. Immune …, 2003 - ncbi.nlm.nih.gov
... Cohen P, Ntambi JM, Friedman JM. Laboratory of Molecular Genetics, The Rockefeller University,
New York, NY 10021, USA. The incidence of obesity has increased dramatically in recent years,
making it one of the most pressing public health concerns worldwide. ...
Cited by 50 - Related articles - BL Direct
... Cohen P, Ntambi JM, Friedman JM. Laboratory of Molecular Genetics, The Rockefeller University,
New York, NY 10021, USA. The incidence of obesity has increased dramatically in recent years,
making it one of the most pressing public health concerns worldwide. ...
Cited by 50 - Related articles - BL Direct
nih.gov [HTML]… Lee, C Zhao, R Darnell, JM Friedman - Proceedings of the …, 1997 - National Acad Sciences
... The decreased level of Ob-Rb in GTG-treated mice suggests that the obesity in these mice results
from the ablation of some Ob-Rb-positive neurons ... Halaas JL,; Gajiwala KS,; Maffei M,; Cohen
SL,; Chait BT,; Rabinowitz D,; Lallone RL,; Burley SK,; Friedman JM. (1995) Science 269 ...
Cited by 462 - Related articles - BL Direct - All 14 versions
... The decreased level of Ob-Rb in GTG-treated mice suggests that the obesity in these mice results
from the ablation of some Ob-Rb-positive neurons ... Halaas JL,; Gajiwala KS,; Maffei M,; Cohen
SL,; Chait BT,; Rabinowitz D,; Lallone RL,; Burley SK,; Friedman JM. (1995) Science 269 ...
Cited by 462 - Related articles - BL Direct - All 14 versions
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