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基因与生物钟研究动态与知识发现

已有 2050 次阅读 2011-1-27 17:34 |个人分类:知识发现|系统分类:论文交流|关键词:学者| 生物钟

 
《自然》:科学家发现独立于基因的生物钟机制
Ancient Body Clock Discovered That Helps Keep All Living Things on Time

http://www.sciencedaily.com/releases/2011/01/110126131540.htm

生物钟控制着生命活动的内在节律,过去人们一直认为它的“驱动齿轮”是基因。而英国研究人员在新一期《自然》杂志上报告说,他们发现了独立于基因的生物钟机制,这种与新陈代谢有关的机制构成了生物钟的“第二齿轮”。

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi?refresh=T&ID=4467

Start A-Literature C-Literature B-list Filter Literature
A-query: circadian clock
C-query: sleep cycles and genes
The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 40 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 4467 and can be accessed from the start page after you leave this session. There are 155 terms on the current B-list (31 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.

To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

job id # 4467 started Thu Jan 27 04:55:19 2011
Max_citations: 50000
Stoplist: /var/www/html/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
4467 Search ARROWSMITH A
A_query_raw: circadian clockThu Jan 27 04:55:50 2011

A query = circadian clock started Thu Jan 27 04:55:50 2011
A query resulted in 8096 titles
4467 Search ARROWSMITH C
C_query_raw: sleep cycles and genes Thu Jan 27 05:04:18 2011

C: sleep cycles and genes 56

A: pubmed_query_A 8096

AC: ( circadian clock ) AND ( sleep cycles and genes ) 40

C query = sleep cycles and genes started Thu Jan 27 05:04:18 2011
C query resulted in 56 titles
A AND C query resulted in 40 titles
155 B-terms ready on Thu Jan 27 05:04:28 2011

B-list on Thu Jan 27 05:09:48 2011
1 expression rat suprachiasmatic
2 rat suprachiasmatic
3 rat suprachiasmatic nucleus
4 suprachiasmatic nucleus
5 sleep wake
6 sleep wake cycle
7 suprachiasmatic
8 c fos
9 bipolar disorder
10 sleep regulation
11 sleep deprivation
12 expression rat
13 c fos expression
14 fos expression
15 variation circadian rhythm
16 biological clock
17 wake
18 sleep
19 activity sleep
20 pacemaker
21 circadian rhythm period
22 variation circadian
23 fos
24 fos expression rat
25 obstructive sleep
26 gonadotropin releasing hormone
27 dopamine receptor
28 clock
29 sleep dependent
30 neurobiology
31 circadian rhythm

 


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