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11位生命科学突破奖得主：5 美国加州大学圣地亚哥分校N.Ferrara
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| 十一位科学家获生命科学巨奖 |
据《自然》网站消息，来自美国、荷兰和日本的11位科学家获得了首届生命科学大奖——“生命科学突破奖”（Breakthrough Prize in Life Sciences）。他们分别获得该奖的五个奖项，每个得奖人将获奖金300万美元，该数目是诺贝尔奖单项奖金（2012年为120万美元）的2.5倍。
1 美国普林斯顿大学教授David Botstein
2 美国哈佛大学教授Eric S. Lander 获基因组学奖
3 美国康奈尔大学教授Lewis C. Cantley
4 荷兰皇家艺术与科学学院Hubrecht研究所教授Hans Clevers
5 美国加州大学圣地亚哥分校教授Napoleone Ferrara
6 美国纪念斯隆•凯特林癌症中心教授Charles L. Sawyers
7 美国约翰•霍普金斯大学教授Bert Vogelstein
8 美国麻省理工学院教授Robert A. Weinberg 获癌症奖
9 美国洛克菲勒大学教授Titia de Lange 获端粒奖
10 日本京都大学山中伸弥Shinya Yamanaka 获干细胞奖
11 美国洛克菲勒大学教授Cornelia I. Bargmann 获神经生物学奖
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Herbert Hurwitz, Louis Fehrenbacher, William Novotny, Thomas Cartwright, John Hainsworth, William Heim, Jordan Berlin, Ari Baron, Susan Griffing, Eric Holmgren, , Gwen Fyfehttp://academic.research.microsoft.com/io.ashx?type=5&id=30050069&selfId1=23429352&selfId2=-1&maxNumber=12&query=
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Vascular endothelial growth factor (VEGF) is a key regulator of physiological angiogenesis during embryogenesis, skeletal growth and reproductive functions. VEGF has also been implicated in pathological angiogenesis associated with tumors, intraocular neovascular disorders and other conditions. The biological effects of VEGF are mediated by two receptor tyrosine kinases (RTKs), VEGFR-1 and VEGFR-2, which differ considerably in signaling properties. ...
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Vascular endothelial growth factor (VEGF) was purified from media conditioned by bovine pituitary folliculostellate cells (FC). VEGF is a heparin-binding growth factor specific for vascular endothelial cells that is able to induce angiogenesis in vivo. Complementary DNA clones for bovine and human VEGF were isolated from cDNA libraries prepared from FC and HL60 leukemia cells, respectively. These cDNAs encode ...
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, Karen Carver-Moore, Helen Chen, Mary Dowd, Lucy Lu, K. Sue O'Shea, Lyn Powell-Braxton, Kenneth J. Hillan, Mark W. MooreANGIOGENESIS is required for a wide variety of physiological and pathological processes1. The endothelial cell-specific mitogen vascular endothelial growth factor (VEGF)2,3 is a major mediator of pathological angiogenesis4-6. Also, the expression of VEGF and its two receptors, Flt-1 and Flk-1/KDR, is related to the formation of blood vessels in mouse and rat embryos7-...
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THE development of new blood vessels (angiogenesis) is required for many physiological processes including embryogenesis, wound healing and corpus luteum formation1,2. Blood vessel neoformation is also important in the pathogenesis of many disorders1-5, particularly rapid growth and metastasis of solid tumours3-5. There are several potential mediators of tumour angiogenesis, including basic and acidic fibroblast growth factors, tumour ...
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Lloyd Paul Aiello, Robert L. Avery, Paul G. Arrigg, Bruce A. Keyt, Henry D. Jampel, Sabera T. Shah, Louis R. Pasquale, Hagen Thieme, Mami A. Iwamoto, John E. Park, Hung V. Nguyen, Lloyd M. Aiellohttp://academic.research.microsoft.com/io.ashx?type=5&id=29930742&selfId1=23429352&selfId2=-1&maxNumber=12&query=
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Journal: Biochemical and Biophysical Research Communications - BIOCHEM BIOPHYS RES COMMUN , vol. 161, no. 2, pp. 851-858, 1989
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The fms-like tyrosine kinase (Flt) is a transmembrane receptor in the tyrosine kinase family. Expression of flt complementary DNA in COS cells conferred specific, high-affinity binding of vascular endothelial growth factor, also known as vascular permeability factor (VEGF-VPF), a factor that induces vascular permeability when injected in the guinea pig skin and stimulates endothelial cell proliferation. Expression ...
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Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen in vitro and an angiogenic inducer in a variety of in vivo models. Hypoxia has been shown to be a major inducer of VEGF gene transcription. The tyrosine ki- nases Flt-1 (VEGFR-1) and Flk-1/KDR (VEGFR-2) are high- affinity VEGF receptors. The role of VEGF ...
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Inhibiting angiogenesis is a promising strategy for treatment of cancer and several other disorders, including age-related macular degeneration. Major progress towards a treatment has been achieved over the past few years, and the first antiangiogenic agents have been recently approved for use in several countries. Therapeutic angiogenesis (promoting new vessel growth to treat ischaemic disorders) is an exciting frontier ...
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Published in 1999.
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Thorsten Cramer, Yuji Yamanishi, Björn E. Clausen, Irmgard Förster, Rafal Pawlinski, Nigel Mackman, Volker H. Haase, Rudolf Jaenisch, Maripat Corr, Victor Nizet, Gary S. Firestein, Hans-Peter Gerberhttp://academic.research.microsoft.com/io.ashx?type=5&id=36137082&selfId1=23429352&selfId2=-1&maxNumber=12&query=Granulocytes and monocytes/macrophages of the myeloid lineage are the chief cellular agents of innate immunity. Here, we have examined the inflammatory response in mice with conditional knockouts of the hypoxia responsive transcription factor HIF-1α, its negative regulator VHL, and a known downstream target, VEGF. We find that activation of HIF-1α is essential for myeloid cell infiltration and ...
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Humanization of an Anti-Vascular Endothelial Growth Factor Monoclonal Antibody for the Therapy of Solid Tumors and Other Disorders (Citations: 351)
Leonard G. Presta, Helen Chen, Shane J. O'Connor, Vanessa Chisholm, Y. Gloria Meng, Lynne Krummen, Marjorie Winkler,Vascular endothelial growth factor (VE(ìF) is a major mediator of angiogenesis associated with tumors and other pathological conditions, including proliferative diahetic retinopathy and age-related macular degeneration. The murine anti-human I (.1 monoclonal antibody imiiM l> I.di i A.4.6.1 has heen shown to potently suppress angio- genesis and growth in a variety of...Published in 1997. -
The ability of tumours to induce new blood-vessel formation has been a major focus of cancer research over the past few decades, and vascular endothelial growth factor (VEGF) is now known to be central to this process. The quest for VEGF and other factors that promote tumour angiogenesis was initiated many decades ago, and a long and complicated path ...
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Journal: Biochemical and Biophysical Research Communications - BIOCHEM BIOPHYS RES COMMUN , vol. 189, no. 2, pp. 824-831, 1992
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Role of vascular endothelial growth factor in the regulation of angiogenesis.Compelling evidence indicates that vascular endothelial growth factor (VEGF) is a fundamental regulator of normal and abnormal angiogenesis. The loss of a single VEGF allele results in defective vascularization and early embryonic lethality. VEGF plays also a critical role in kidney development, and its inactivation during early postnatal life ...
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Published in 2001.
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Min Bao, Leo Deguzman, Stuart Bunting, Franklin V. Peale Jr., , Hope Steinmetz, John Hoeffel, Jeffrey L. Cleland, Ann Daugherty, Nicholas van Bruggen, H. Paul Redmond, Richard A. D. Caranohttp://academic.research.microsoft.com/io.ashx?type=5&id=15164851&selfId1=23429352&selfId2=-1&maxNumber=12&query=Several growth factors are expressed in distinct temporal and spatial patterns during fracture repair. Of these, vascular endothelial growth factor, VEGF, is of particular interest because of its ability to induce neovascularization (angiogenesis). To determine whether VEGF is required for bone repair, we inhibited VEGF activity during secondary bone healing via a cartilage intermediate (endochondral ossification) and during direct bone ...Journal: Proceedings of The National Academy of Sciences - PNAS , vol. 99, no. 15, pp. 9656-9661, 2002
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H. P. Gerber, K. J. Hillan, A. M. Ryan, J. Kowalski, G. A. Keller, L. Rangell, B. D. Wright, F. Radtke, M. Aguet,Published in 1999.
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Journal: Biochemical and Biophysical Research Communications - BIOCHEM BIOPHYS RES COMMUN , vol. 181, no. 2, pp. 902-906, 1991
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Hans-Peter Gerber, Ajay K. Malik, Gregg P. Solar, Daniel Sherman, Xiao Huan Liang, Gloria Meng, Kyu Hong, James C. Marsters,Vascular endothelial growth factor (VEGF) is a principal regulator of blood vessel formation and haematopoiesis, but the mechanisms by which VEGF differentially regulates these processes have been elusive. Here we describe a regulatory loop by which VEGF controls survival of haematopoietic stem cells (HSCs). We observed a reduction in survival, colony formation and in vivo repopulation rates of HSCs after ...
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The existence of factors that stimulate blood vessel growth, thereby recruiting a neovascular supply to nourish a growing tumour, was postulated many decades ago, although the identification and isolation of these factors proved elusive. Now, vascular endothelial growth factor (VEGF), which was identified in the 1980s, is recognized as an essential regulator of normal and abnormal blood vessel growth. In ...
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The hyperpermeability of tumor vessels to macromolecules, compared with normal vessels, is presumably due to vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) released by neoplastic and/or host cells. In addition, VEGF/VPF is a potent angiogenic factor. Removal of this growth factor may reduce the permeability and inhibit tumor angiogenesis. To test these hypotheses, we transplanted a ...Journal: Proceedings of The National Academy of Sciences - PNAS , vol. 931, no. 25, pp. 14765-14770, 1996
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Jennifer LeCouter, Dirk R. Moritz, Bing Li, Gail Lewis Phillips, Xiao Huan Liang, Hans-Peter Gerber, Kenneth J. Hillan,The vascular endothelium was once thought to function primarily in nutrient and oxygen delivery, but recent evidence suggests that it may play a broader role in tissue homeostasis. To explore the role of sinusoidal endothelial cells (LSECs) in the adult liver, we studied the effects of vascular endothelial growth factor (VEGF) receptor activation on mouse hepatocyte growth. Delivery of VEGF-...
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Published in 1999.
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Angiogenesis, or formation of new blood vessels from pre-existing ones, is essential for normal development and wound healing/reproductive functions in adults. Abnormal regulation of angiogenesis has been implicated in the pathogenesis of several disorders, including cancer. Vascular endothelial growth factor (VEGF)-A is a pivotal stimulator of angiogenesis because its binding to VEGF receptors has been shown to ...
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Vascular endothelial growth factor (VEGF) is a diffusible endothelial cell-specific mitogen and angiogenic factor that can also increase vascular permeability. By alternative splicing of mRNA, VEGF may exist as one of four different isoforms that have similar biological activities but differ markedly in targeting and bioavailability. The VEGF receptors are specifically expressed in the cell surface of vascular endothelial ...
Journal: Breast Cancer Research and Treatment - BREAST CANCER RES TREAT , vol. 36, no. 2, pp. 127-137, 1995
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https://m.sciencenet.cn/blog-280034-664031.html
上一篇：11位生命科学突破奖得主：4 荷兰皇家艺术与科学学院 H. Clevers
下一篇：11位生命科学突破奖得主：6 - 11位科学家的学术影响力
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