Andrew fire, an American scientist and biomedical scientist, was born in 1959 in the United States. In 1983, he received his Ph.D. in biology from the Massachusetts Institute of technology. In 1998, he and Craig Mello, Professor of the University of Massachusetts School of medicine, published a paper in the journal Nature, saying that they had discovered that RNA could interfere with genes. They won the 2006 Nobel Prize in physiology or medicine together for their outstanding contributions to RNA (ribonucleic acid) interference mechanism. Andrew Farr is Professor of pathology and genetics at Stanford medical school.

安德鲁·法尔（AndrewFire），美国科学家、生物医学家，1959年出生于美国，美国科学家、生物医学家。1983年获美国麻省理工学院生物学博士学位。1998年，他和美国马萨诸塞大学医学院教授克雷格·梅洛在《自然》杂志上共同发表论文，称他们发现了RNA具有可以干扰基因的机制。因在RNA（核糖核酸）干扰机制方面的突出贡献，他俩一起获得了2006年度诺贝尔生理学或医学奖。安德鲁·法尔现任斯坦福医学院病理学和遗传学教授。

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https://pubmed.ncbi.nlm.nih.gov/18007671/

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https://pubmed.ncbi.nlm.nih.gov/17722137/

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Abstract

Thanks to the Nobel Foundation for permission to publish this Lecture. We report here the Nobel Lecture delivered by Professor Andrew Z Fire. Together with the accompanying lecture by Professor Mello this lecture describes the exciting years leading to the discovery of RNA interference (RNAi) and some of the underlying molecular mechanisms. Professor Fire nicely points out his own contribution and the contribution of other research groups to the development of this field. He also presents an interesting discussion on the role of RNAi in immunity and challenges us with a number of open questions. The lecture ends presenting the great potential of exploiting RNAi for therapeutical purposes.

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Publication types

• Lecture

MeSH terms

• Animals

• Caenorhabditis elegans / genetics

• Gene Silencing*

• Immunity

• Models, Biological

• RNA Interference

• RNA, Double-Stranded / metabolism*

Substances

• RNA, Double-Stranded

Related information

• PubChem Compound (MeSH Keyword)

LinkOut - more resources

• Full Text Sources

• Nature Publishing Group

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MeSH terms

• Animals

• Gene Silencing*

• Humans

• Immune System

• Nobel Prize*

• RNA Interference*

• RNA, Double-Stranded*

Substances

• RNA, Double-Stranded

Related information

• Cited in Books

• PubChem Compound (MeSH Keyword)

Grant support

• R01 GM037706/GM/NIGMS NIH HHS/United States

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• Wiley

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