Guangying Luo (SXAU)

Environmental Toxins is Risk Factor for Autism?

摘要：自闭症是一种典型的行为紊乱疾病，其主要特征社会交往障碍、语言障碍、动作刻板、反复以及缺乏兴趣。每年的4月2日为国际自闭症日。但是自闭症的病因一直不明。作为一个环境毒理学的科研工作者，我提出一个疑问：环境毒素是自闭症的风险因子？本文对环境毒素的神经毒理研究做一综述。

Abstract: Autism is a behaviorally characterized disorder with impairments in social interactions, as well as stereotyped, repetitive patterns of behaviors and interests. April 2nd is Autism Awareness Day. However, the etiology of autism is still unknown. As a science research worker of environmental toxicology, I have a question: Environmental toxins is risk factor for autism? This paper reviews the recent studies on neurotoxcity of environmental toxins.

关键词：自闭症；环境毒素；PBDE；PCB；BPA；PCDD

Keywords: autism, environmental toxins, PBDE；PCB；BPA；PCDD

知识发现平台  http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi

Start A-Literature C-Literature B-list Filter Literature

A-query: Autism C-query: Environmental Toxins The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 21 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 20372 and can be accessed from the start page after you leave this session. There are 715 terms on the current B-list (232 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin. To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

 

 

知识发现结果  http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/view_b_txt.cgi?ID=20372

 

job id # 20372 started Tue Mar 29 22:51:12 2011
Max_citations: 50000
Stoplist: /var/www/html/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
20372 Search ARROWSMITH A
A_query_raw: AutismTue Mar 29 22:51:40 2011

A query = Autism started Tue Mar 29 22:51:40 2011
A query resulted in 17240 titles
20372 Search ARROWSMITH C
C_query_raw: Environmental Toxins Tue Mar 29 22:52:04 2011

C: Environmental Toxins 18046

A: pubmed_query_A 17240

AC: ( Autism ) AND ( Environmental Toxins ) 21

C query = Environmental Toxins started Tue Mar 29 22:52:05 2011
C query resulted in 18046 titles
A AND C query resulted in 21 titles
8770 B-terms ready on Tue Mar 29 22:54:35 2011

Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
715 B-terms left after filter executed Tue Mar 29 23:20:47 2011

B-list on Tue Mar 29 23:21:41 2011
1 toll receptor
2 gstm1
3 transporter gene
4 single nucleotide polymorphism
5 genome scan
6 akt
7 cytokine production
8 gastrin releasing peptide
9 genome wide
10 pten
11 snp
12 mthfr
13 homeobox
14 gene cluster
15 promoter polymorphism
16 beta catenin
17 epileptiform
18 gene environment
19 bdnf
20 toll
21 cpg
22 gaba a receptor
23 microrna
24 doublecortin
25 paraoxonase
26 gabaa
27 quantitative trait loci
28 vntr
29 inflammatory bowel disease
30 gene promoter
31 gaba a
32 jnk
33 clock gene
34 leptin
35 glutamate receptor gene
36 tetranucleotide repeat
37 paraoxonase gene
38 bhlh
39 gene variant
40 organization promoter
41 microsatellite
42 cdna
43 adhd
44 glutamate receptor
45 protein kinase b
46 th1
47 pcr
48 promoter region
49 tlr
50 stat3
51 trpv1
52 cytokine
53 opioid receptor
54 cloning gene
55 transducin
56 per1
57 gata-3
58 allelic variant
59 ampa
60 pacap
61 trinucleotide
62 exon
63 novel gene
64 bcl-2
65 aquaporin
66 twin
67 epilepsy
68 abcb1
69 tumor suppressor gene
70 gene encoding
71 estrogen receptor alpha
72 bdnf gene
73 metallothionein
74 ubiquitin
75 repressor
76 tachykinin
77 pcb
78 il-1
79 transporter
80 tetranucleotide
81 adrenomedullin
82 gaba
83 cd8
84 killer
85 transcription factor
86 phospholipase
87 il-6
88 genomic
89 lc
90 gene family
91 dpt
92 cue
93 apoe
94 glutathione s transferase
95 candidate gene
96 channel gene
97 intron
98 calmodulin
99 myelin basic protein
100 anxiety
101 signal peptide
102 cell adhesion molecule
103 gef
104 allelic heterogeneity
105 calcium channel
106 s100b
107 snap-25
108 tyrosine kinase
109 mdr1
110 cyclin
111 map2
112 theta
113 ms
114 untranslated region
115 vitamin d receptor
116 tandem repeat
117 milk
118 protein kinase c
119 spatial learning
120 untranslated
121 genome
122 glucose transporter
123 related gene
124 rna binding protein
125 nnos
126 tumor necrosis factor
127 oxytocin
128 cadherin
129 somatostatin receptor
130 lip
131 connexin
132 dopamine d2 receptor
133 g protein
134 tumor suppressor
135 mri
136 gene associated
137 gfap
138 trait
139 ect2
140 fibroblast growth factor
141 parkinson disease
142 chemokine
143 5-ht
144 ngf
145 p53
146 circling
147 heat shock protein
148 mhc haplotype
149 il-2
150 han
151 cd4
152 phosphodiesterase
153 cd3
154 expression gene
155 crh
156 ecd
157 meta
158 interferon gamma
159 neuropeptide
160 receptor gene
161 olfactory
162 hepatocyte growth factor
163 dopamine receptor
164 vasoactive intestinal peptide
165 p22
166 ribosomal protein
167 mhc
168 domain
169 reduced expression
170 copy
171 rora
172 hla
173 gene silencing
174 rho
175 erk
176 ige
177 lh
178 intronic
179 immune response
180 adenylate cyclase
181 gene involved
182 integrin
183 promoter
184 a2
185 allele
186 gene related
187 caveolin-1
188 epidermal growth factor
189 high mobility group
190 task
191 enhancer
192 rhoa
193 protein gene
194 pet
195 dhfr
196 cdc
197 p glycoprotein
198 sun
199 clock
200 trh
201 gene knockout
202 lobe
203 sri
204 conductance
205 insulin growth factor
206 dna binding protein
207 opiate receptor
208 met
209 allelic
210 isoform
211 estrogen receptor
212 gene japanese
213 gene association
214 neurotensin
215 efflux
216 protein kinase
217 startle response
218 ornithine carbamoyltransferase
219 fold
220 thyrotropin releasing hormone
221 dopamine beta hydroxylase
222 glutamic acid decarboxylase
223 precocious
224 cre
225 dna sequence
226 tac
227 3h
228 p1
229 peptidase
230 s6
231 na v
232 rsh

gstm1与Autism、 Environmental Toxins 研究论文：

Autism

gstm1

Environmental Toxins

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/show_sentences.cgi

Start A-Literature C-Literature B-list Filter Literature

AB literature B-term BC literature Autism gstm1 Environmental Toxins 1: Animal model of autism using GSTM1 knockout mice and early post-natal sodium valproate treatment. 2010 Add to clipboard 2: Analysis of case-parent trios at a locus with a deletion allele: association of GSTM1 with autism. 2006 Add to clipboard 1: Sulforaphane- and Phenethyl isothiocyanate-Induced Inhibition of Aflatoxin B1-Mediated Genotoxicity in Human Hepatocytes: Role of GSTM1 genotype and CYP3A4 Gene Expression. 2010 Add to clipboard 2: Glutathione S-transferase M1 (GSTM1) polymorphisms and lung cancer: a literature-based systematic HuGE review and meta-analysis. 2008 Add to clipboard 3: Alterations of liver function test indices of filling station workers with respect of genetic polymorphisms of GSTM1 and GSTT1. 2005 Add to clipboard 4: Possible risk modification by CYP1A1, GSTM1 and GSTT1 gene polymorphisms in lung cancer susceptibility in a South Indian population. 2005 Add to clipboard 5: Increased frequencies of glutathione S-transferase (GSTM1 and GSTT1) gene deletions in Korean patients with acquired aplastic anemia. 2001 Add to clipboard 6: Peculiarities of the GSTM1 0/0 genotype in French heavy smokers with various types of chronic bronchitis. 1997 Add to clipboard 7: Proportion of the GSTM1 0/0 genotype in some Slavic populations and its correlation with cystic fibrosis and some multifactorial diseases. 1996 Add to clipboard