博文
癌症免疫学研究进展与信息分析（1947-2012年）
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今年首先来自华盛顿大学医学院等处的研究人员通过癌细胞测序分析，发现了一种能让癌细胞暴露的突变，这种突变就像是给癌细胞装上了红旗，使得免疫系统容易清除这些癌细胞。 免疫系统网络复杂，需要通过警示，靶向，和安全制动来确定攻击的时间和方式，这一新研究成果表明科学家们也许能将DNA测序数据与免疫警示的启动，靶向结合起来，更精确的研发针对癌症的疫苗和其它免疫治疗方案。此外，来自瑞士日内瓦大学等处的研究人员发现了免疫学新的基础性机制——当面对病毒侵袭的时候，免疫系统还有另外一种可以用于对付病毒攻击的基础机制，这将可以用于疫苗研制，帮助防治传染疾病和癌症。 在2013年，通过将两种针对不同生物通道的靶向免疫疗法结合，也许能得到更好的抗癌临床试验结果。
Science盘点2013科研热点
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| 2011 | 2,685 | |
| 2010 | 2,597 | |
| 2008 | 2,571 | |
| 2009 | 2,559 | |
| 2007 | 2,529 | |
| 2005 | 2,378 | |
| 2012 | 2,354 | |
| 2006 | 2,332 | |
| 2004 | 2,218 | |
| 2003 | 2,124 | |
| 2002 | 2,062 | |
| 2001 | 1,896 | |
| 2000 | 1,710 | |
| 1999 | 1,546 | |
| 1998 | 1,362 | |
| 1997 | 1,333 | |
| 1996 | 1,257 | |
| 1995 | 1,144 | |
| 1994 | 1,134 | |
| 1993 | 1,101 | |
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| United States | 16,628 | |
| Japan | 3,421 | |
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| France | 1,762 | |
| China | 1,591 | |
| Netherlands | 1,194 | |
| Australia | 844 | |
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| Israel | 602 | |
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| Sweden | 579 | |
| Switzerland | 564 | |
| Belgium | 422 | |
| South Korea | 408 | |
| Austria | 297 | |
| Poland | 247 | |
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| Boston | 858 | |
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| Los Angeles | 631 | |
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| Tokyo | 592 | |
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| Pittsburgh | 515 | |
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| Heidelberg | 362 | |
| Durham | 355 | |
| Beijing | 327 | |
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| München | 289 | |
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| Cancer Res | 1,963 | |
| J Immunol | 1,554 | |
| Blood | 1,294 | |
| Cancer Immunol Immun | 1,124 | |
| Bone Marrow Transpl | 1,112 | |
| Int J Cancer | 970 | |
| Clin Cancer Res | 846 | |
| Cancer | 759 | |
| J Immunother | 664 | |
| J Natl Cancer I | 594 | |
| Brit J Cancer | 465 | |
| Anticancer Res | 455 | |
| Vaccine | 443 | |
| J Clin Oncol | 439 | |
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| Cancer Immunol Immunother | 380 | |
| P Natl Acad Sci Usa | 319 | |
| Leukemia | 313 | |
| J Exp Med | 310 | |
| Brit J Haematol | 298 | |
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| Patients | 23,577 | |
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| Immunization | 20,452 | |
| Immunity | 19,143 | |
| Mice | 16,239 | |
| T-Lymphocytes | 16,226 | |
| Antigens | 13,650 | |
| antigen binding | 11,755 | |
| Vaccination | 11,524 | |
| Antibodies | 11,479 | |
| Lymphocytes | 10,997 | |
| Adult | 10,843 | |
| Vaccines | 10,561 | |
| Middle Aged | 10,423 | |
| Therapeutics | 8,753 | |
| immune response | 8,282 | |
| Antibodies, Monoclonal | 8,027 | |
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