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20181018概览
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2018-10-18 22:22
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CRISPR-induced exon skipping is dependent on premature termination codon mutations GB 李占军; 赖学良 吉林大学 https://genomebiology.biomedcentral.com/articles/10.1186/s13059-018-1532-z CRISPR导致的外显子跳跃(已发现的现象)是由于PTC突变导致的 NAS 改变 (用兔子line ...
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个人分类: 百日千篇|2063 次阅读|没有评论
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20181017概览
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2018-10-17 20:44
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New details of HIV life cycle --Small molecule as potential treatment target Nature Sep. https://www.sciencedaily.com/releases/2018/10/181005111453.htm 小分子IP6在HIV病毒成熟和不成熟阶段起重要作用,包括病毒衣壳的组装。通过计算机模拟了HIV衣壳与IP6的作用,以及乙型肝炎病毒等的模拟,想了解逆转 ...
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个人分类: 百日千篇|1363 次阅读|没有评论
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20181016概览
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2018-10-16 20:33
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A Mutant p53-Dependent Embryonic Stem Cell Gene Signature Is Associated with Augmented Tumorigenesis of Stem Cells cancer res. http://cancerres.aacrjournals.org/content/78/20/5833 33:00 抑癌基因P53突变-人癌症种最常见突变types【P53-inavtivating mutation P53 onco ...
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个人分类: 百日千篇|1788 次阅读|没有评论
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20181015概览
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2018-10-15 23:41
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Dlk1-Dio3 locus-derived LncRNAs perpetuate postmitotic motor neuron cell fate and subtype identity elife https://elifesciences.org/articles/38080 Dlk1-Dio3 locus产生很多lncRNAs from 母源来的染色体(父源印记): Meg3 (Gtl2),在干细胞和肿瘤中鉴定 ...
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个人分类: 百日千篇|2469 次阅读|没有评论
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Molecular Cell- Epigenetic; gene replication; checkpoint
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2018-7-12 17:27
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个人分类: 百日千篇|1727 次阅读|没有评论
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