博文
Journal club: Cell fate as a high-dimensional attractor of a complex gene regula
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Today I present a Physics Review Letter paper named “Cell fate as a high-dimensional attractor of a complex gene regulatory network” in the journal club of our group.
To my surprise, the response is quite polarized. For some people, they take for granted that cell types are attractors in gene network (maybe because that we are in the physics institute for complex system anyhow). They think that it is nothing more than just rewriting the biological facts in the physics language ( I don’t know how many biologists actually accept this hypothesis. It is more widely accepted that cell types arise from turning on the type-specific Transcription Factors). They also complained that the 2-gene cross-inhibition example is too simple to demonstrate the effects of high-dimensional gene regulation space. They demanded a clear mathematical formula for cell reprogramming in the gene network.
However, other people quickly recognized the importance of the paper and began to embrace this idea enthusiastically. We even begin to discuss how to build such a network. One guy even suggest the possibility to invite the author here for giving a talk by himself.
Maybe a good journal club presentation is not to get the consensus of everybody. Rather it can arise the true interests of the people.
https://m.sciencenet.cn/blog-3468-224729.html
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