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SSB专刊推荐┃Pathway and protein engineering for biosynthesis

已有 1652 次阅读 2022-7-15 11:49 |系统分类:博客资讯

合成生物学的飞速发展将有助于建立高效生物合成生物系统,实现化学品或天然产物的绿色可持续生产。然而,构建生物合成路线充满挑战,其需要高效酶、生物合成途径以及便捷的使能技术。蛋白质 (酶) 是生命活动的直接执行者,也是构建高效生物合成途径的重要元素,通过酶的挖掘蛋白质工程对酶进行系统表征与改造,提高酶催化性能以及关键步骤的合成效率。进一步利用工程化思维将不同酶分子组装为代谢途径与网络,并通过途径工程平衡代谢网络,以提高生物合成效率。此外,便捷的使能技术将有促于酶分子、代谢途径和细胞整体性能优化,从而促进目标产物生物合成效率。

为了更好地探索蛋白质和途径工程,助力生物合成的前沿进展,Synthetic and Systems Biotechnology特别设置“Pathway and Protein Engineering for Biosynthesis”为主题的特刊,由大连化学物理研究所周雍进研究员、德国歌德大学的Martin Grininger教授与德克萨斯大学奥斯汀分校的Hal Alper教授担任特约编辑,邀请多位国内外知名学者分享其科研成果。本次特刊共收录八篇评论文章和九篇原创研究文章,重点介绍和展示了Pathway and Protein Engineering及其在合成生物学应用中的最新进展。


https://www.sciencedirect.com/journal/synthetic-and-systems-biotechnology/special-issue/10LWCQ2BJWN


文 章 列 表 


#01

Identification of (-)-bornyl diphosphate synthase from Blumea balsamifera and its application for (-)-borneol biosynthesis in Saccharomyces cerevisiae

Guanghong Cui & Luqi Huang, et al.

Synth. Syst. Biotechnol., Volume 7, Issue 1, March 2022, Pages 490-497

https://doi.org/10.1016/j.synbio.2021.12.004


#02

Protein-protein interface analysis of the non-ribosomal peptide synthetase peptidyl carrier protein and enzymatic domains

Joshua C. Corpuz, Javier O. Sanlley, Michael D. Burkart

Synth. Syst. Biotechnol., Volume 7, Issue 2, June 2022, Pages 677-688

https://doi.org/10.1016/j.synbio.2022.02.006



#03

Fragment antigen binding domains (Fabs) as tools to study assembly-line polyketide synthases

Katarina M. Guzman, Chaitan Khosla

Synth. Syst. Biotechnol., Volume 7, Issue 1, March 2022, Pages 506-512

https://doi.org/10.1016/j.synbio.2021.12.003



#04

Glycosyltransferases: mining, engineering and applications in biosynthesis of glycosylated plant natural products

Guang-Yu Yang et al.

Synth. Syst. Biotechnol., Volume 7, Issue 1, March 2022, Pages 602-620

https://doi.org/10.1016/j.synbio.2022.01.001



#05

Current state and future perspectives of cytochrome P450 enzymes for C–H and C=C oxygenation

Wei Song et al.

Synth. Syst. Biotechnol., Volume 7, Issue 3, September 2022, Pages 887-899

https://doi.org/10.1016/j.synbio.2022.04.009



#06

Enhanced production of poly-γ-glutamic acid via optimizing the expression cassette of Vitreoscilla hemoglobin in Bacillus licheniformis

Dong Wang & Shouwen Chen et al.

Synth. Syst. Biotechnol., Volume 7, Issue 1, March 2022, Pages 567-573

https://doi.org/10.1016/j.synbio.2022.01.006



#07

One stone two birds: biosynthesis of 3-hydroxypropionic acid from CO2 and syngas-derived acetic acid in Escherichia coli

Hui Wu et al.

Synth. Syst. Biotechnol., Volume 6, Issue 3, September 2021, Pages 144-152

https://doi.org/10.1016/j.synbio.2021.06.003



#08

Reprogramming the metabolism of Synechocystis PCC 6803 by regulating the plastoquinone biosynthesis

Hui Wu et al.

Synth. Syst. Biotechnol., Volume 6, Issue 4, December 2021, Pages 351-359

https://doi.org/10.1016/j.synbio.2021.10.004



#09

Pathway engineering strategies for improved product yield in yeast-based industrial ethanol production

Robert Mans et al.

Synth. Syst. Biotechnol., Volume 7, Issue 1, March 2022, Pages 554-566

https://doi.org/10.1016/j.synbio.2021.12.010



#10

Increasing the heterologous production of spinosad in Streptomyces albus J1074 by regulating biosynthesis of its polyketide skeleton

Ran Liu & Tiangang Liu et al.

Synth. Syst. Biotechnol., Volume 6, Issue 4, December 2021, Pages 292-301

https://doi.org/10.1016/j.synbio.2021.09.008



#11

Complex peptide natural products: biosynthetic principles, challenges and opportunities for pathway engineering

Eric J.N. Helfrich et al.

Synth. Syst. Biotechnol., Volume 7, Issue 1, March 2022, Pages 631-647

https://doi.org/10.1016/j.synbio.2022.01.007



#12

Strategies to increase tolerance and robustness of industrial microorganisms

Yun Chen et al.

Synth. Syst. Biotechnol., Volume 7, Issue 1, March 2022, Pages 533-540

https://doi.org/10.1016/j.synbio.2021.12.009



#13

Research progress of pathway and genome evolution in microbes

Yunzi Luo et al.

Synth. Syst. Biotechnol., Volume 7, Issue 1, March 2022, Pages 648-656

https://doi.org/10.1016/j.synbio.2022.01.004



#14

Engineered DNase-inactive Cpf1 variants to improve targeting scope for base editing in E. coli

Chunbo Lou & Bian Wu et al.

Synth. Syst. Biotechnol., Volume 6, Issue 4, December 2021, Pages 326-334

https://doi.org/10.1016/j.synbio.2021.09.002



#15

Characterizing and engineering promoters for metabolic engineering of Ogataea polymorpha

Xiaoyu Guo & Jiaoqi Gao et al.

Synth. Syst. Biotechnol., Volume 7, Issue 1, March 2022, Pages 498-505

https://doi.org/10.1016/j.synbio.2021.12.005



#16

A FAIR-compliant parts catalogue for genome engineering and expression control in Saccharomyces cerevisiae

Michael K. Jensen et al.

Synth. Syst. Biotechnol., Volume 7, Issue 2, June 2022, Pages 657-663

https://doi.org/10.1016/j.synbio.2022.02.001



#17

Comparative proteomics analysis of Pichia pastoris cultivating in glucose and methanol

Yongjin Zhou & Lihua Zhang et al.

Synth. Syst. Biotechnol., Volume 7, Issue 3, September 2022, Pages 862-868

https://doi.org/10.1016/j.synbio.2022.04.005





 期 刊 介 绍 


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Synthetic and Systems Biotechnology 是高质量国际开放获取期刊,创刊于2016年。期刊覆盖合成生物学、系统生物学以及生物医药等领域的各个方面。

Synthetic and Systems Biotechnology 发表的文章和期刊征稿活动将及时在公众号进行分享,欢迎学者们关注话题集#合成和系统生物技术(SSB),及时掌握期刊研究动态。


期刊现已被SCIE、EMBASE、PubMed Central、Scopus、CSCD等重要数据库收录。

  • 2021 Impact Factor: 4.692;

    5-Year Impact Factor: 5.23; JCR分区Q2

  • 2021 CiteScore: 6.60, 位列学科Q1区

  • 2021中科院分区2区

  • 入选2019年中国科技期刊卓越行动计划高起点新刊项目





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