氢分子医学分享 http://blog.sciencenet.cn/u/孙学军 对氢气生物学效应感兴趣者。可合作研究:sunxjk@hotmail.com 微信 hydrogen_thinker

博文

呼吸少量氢气能有效治疗脑创伤,改善脑功能

已有 7036 次阅读 2010-7-23 16:32 |个人分类:呼吸氢气|系统分类:科研笔记|关键词:学者| 氢气

 

脑创伤是一种严重的创伤,在年轻人中容易发生,可导致死亡和严重神经功能障碍。呼吸氢气通过选择性抗氧化治疗疾病,脑创伤的病理生理过程中也与氧化损伤关系密切。来自中国第四军医大学西京医院神经外科的研究表明,呼吸氢气能有效治疗大鼠脑创伤,该研究给氢气方法是在损伤后5分钟到5小时连续呼吸2%的氢气,通过检测脑水肿、血脑屏障、神经功能和损伤体积等指标,研究结果发现,呼吸氢气对脑创伤的治疗效果明显。通过对抗氧化酶和氧化损伤指标的检测发现,氢气能增加脑组织抗氧化能力,减轻脑创伤后脑组织氧化损伤。研究提示,呼吸氢气可通过减轻氧化应激改善脑创伤程度。给临床治疗该疾病提供了一个重要思路。这个文章也是中国的第17篇论著(见氢气全部文献汇编)。

 

评价,第四军医大学西京医院麻醉科已经发表了2篇呼吸氢气治疗系统炎症方面的文章,本文章是其第三篇论文,从研究思路上,尽管模型是新的,研究的手段没有特别。研究手段包括,采用Evans Blue测定血脑屏障、干湿比测定含水量、行为学检测运动能力、SOD CATMDA等检测氧化指标,可以说简单便宜,估计总经费不超过1万元就可以做出来了。

 

显然该研究可以从炎症角度(测定各种因子和一些信号分子)、细胞碉亡角度(形态学、蛋白或活性检测)进行扩展。从血脑屏障角度,可以从检测血脑屏障方法(IgG)相关因子(MMP水通道等)。从氧化应激角度,可以从内质网应激角度深入。也可以从兴奋毒性角度检测各种神经递质水平。总之,想象的空间很大。这个工作与长征医院麻醉科关于脊髓损伤研究可以形成对应,都属于中枢神经系统创伤类的研究。

 

Beneficial effects of hydrogen gas in a rat model of traumatic brain injury via reducing oxidative stress

Xituan Jia, 1, Wenbo Liua, 1, Keliang Xieb, 1, Weiping Liua, Yan Qua, Xiaodong Chaoa, Tao Chena, Jun Zhouc and Zhou Feia, ,

a Department of Neurosurgery, Xijing Institute of Clinical Neuroscience, Xiing Hospital, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, P. R. China

b Department of Anesthesiology, General Hospital of Tianjin Medical University, Tianjin 300052, P. R. China

c Department of Pharmacy, Urumqi General Hospital of PLA, Urumqi 830000, P. R. China

Accepted 14 July 2010. 

Available online 21 July 2010.

 

Abstract

Traumatic brain injury (TBI) is a leading cause of mortality and disability among the young population. It has been shown that hydrogen gas (H2) exerts a therapeutic antioxidant activity by selectively reducing hydroxyl radical (•OH, the most cytotoxic ROS). Recently, we have found that H2 inhalation significantly improved the survival rate and organ damage of septic mice. In the present study, we investigated the effectiveness of H2 therapy on brain edema, blood-brain barrier (BBB) breakdown, neurological dysfunction and injury volume in TBI-challenged rats. In addition, we investigated the effects of H2 treatment on the changes of oxidative products and antioxidant enzymes in brain tissue of TBI-challenged rats. Hydrogen treatment was given by exposure to 2% H2 from 5 minutes to 5 hours after sham or TBI operation, respectively. Here, we found that TBI-challenged rats showed significant brain injuries characterized by the increase of BBB permeability, brain edema and lesion volume as well as neurological dysfunction, which was significantly attenuated by 2% H2 treatment. In addition, we found that the decrease of oxidative products and the increase of endogenous antioxidant enzymatic activities in brain tissue may be associated with the protective effects of H2 treatment in TBI-challenged rats. The present study supports that H2 inhalation may be a more effective therapeutic strategy for patients with TBI.

Keywords: Traumatic brain injury (TBI); reactive oxygen species (ROS); oxidative stress; hydrogen gas

201007

https://m.sciencenet.cn/blog-41174-346688.html

上一篇:肠道细菌与多发性硬化症的发生关系密切
下一篇:氢气对新生儿窒息后脑损伤有保护作用

6 苗元华 许培扬 郑永军 zhangling dulizhi95 taipan

发表评论 评论 (3 个评论)

数据加载中...
扫一扫,分享此博文

Archiver|手机版|科学网 ( 京ICP备07017567号-12 )

GMT+8, 2022-12-2 00:45

Powered by ScienceNet.cn

Copyright © 2007- 中国科学报社

返回顶部