氢分子医学分享 http://blog.sciencenet.cn/u/孙学军 对氢气生物学效应感兴趣者。可合作研究:sunxjk@hotmail.com 微信 hydrogen_thinker

博文

氦氧混合气对脑缺血治疗作用

已有 6079 次阅读 2011-5-17 08:35 |个人分类:氦气生物学|系统分类:科研笔记|关键词:学者| office, style, 混合气

由于氦气的分子量小、呼吸阻力小、无任何麻醉作用,因此,氦氧混合气长期用于大深度潜水作业,在临床上很早就用于急慢性阻塞性呼吸困难。由于氦气属于惰性气体,在生物体内几乎绝对不可能与其他物质发生化学反应,因此一直认为氦气无任何生物学效应。不过最近几年发现呼吸氦气具有心脏和脑保护效应,这一效应的发现,让人们不得不重新审视氦气的生物学效应。虽然氦气不可能与其他物质发生化学反应,但不等于氦气不会产生生物学效应。潜水医学研究早就发现,高压可以导致神经兴奋,就是所谓的高压神经综合征,就是在研究氦氧混合气潜水过程中发现的。而且氦气由于具有更大的热比容,呼吸氦气容易导致体热散失,增加热量散失必然可以造成生物学效应。另外,呼吸氦气时,体内氮可以发生脱饱和,也许大家认为氮是没有生物学效应的,这也是一个误解。

因此从道理上看,呼吸氦气产生生物学效应是有可能的。最近的研究发现,预先呼吸氦气可以保护心脏和脑缺血。本研究是在过去研究基础上,探讨是否延迟呼吸氦气仍具有脑保护效应。当然结果发现,这种保护效应只能在缺血即刻,这对临床治疗来说是个不幸的消息,因为这样导致其应用价值大大折扣,因为只能在发生疾病后马上呼吸才有价值,很少有临床患者具有这样的可能。不过,这一研究并不能否定这一可能,因为呼吸的时间和方式仍有可以改进的。例如可以呼吸时间延长,呼吸可以采用间歇方式,另外,也许延迟时间更长一些可能会有效果,不过这一研究会延迟这些研究的开展。因为大家都会为表面现象所迷惑。或者盲目相信试验结果。

摘要就不翻译了,有兴趣的童鞋自己研究吧。

The effect of heliox treatment in a rat model of focal transient cerebral ischemia Neuroscience Letters
References and further reading may be available for this article. To view references and further reading you must purchase this article.

Yi Pana, , , Haibo Zhanga, Aninda B. Acharyaa, Salvador Cruz-Floresa and W. Michael Pannetonb

a Department of Neurology & Psychiatry, Saint Louis University, 1438 S. Grand Boulevard, Saint Louis, MO 63104, USA

b Department of Pharmacological and Physiological Science, Saint Louis University, Saint Louis, MO 63104, USA

Received 22 February 2011; 

revised 31 March 2011; 

accepted 19 April 2011. 

Available online 27 April 2011.

 

Abstract

Manipulation of inhaled gases during ischemia/reperfusion is a potential novel therapy for acute stroke. We previously found that treatment with a mixture of 70%/30% helium/oxygen (heliox) or 100% oxygen protects the brain against acute focal ischemia–reperfusion injury. This study evaluates the potential neuro-protective effects of delayed heliox treatment and its dose response effects in a rat transient focal cerebral ischemia model. Adult male rats were subjected to 2-h middle cerebral artery occlusion and then assigned to 1 of 4 inhaled gas exposure groups: I: 70%/30% nitrogen/oxygen (control); II: 70%/30% helium/oxygen administered immediately after occlusion; III: 70%/30% helium/oxygen administered after a 30–60 min delay; or, IV: 40%/30%/30% nitrogen/helium/oxygen administered immediately after occlusion. Outcome measurements included infarct size and neurological deficit score. Mean infarct sizes from groups I to IV were 228, 35, 109, and 124 mm3 respectively (p = 0.012). Only group II had significantly smaller infarct size compared to the control group (p = 0.008). In addition, only Group II had a significantly lower neurological deficit score at 24 h post ischemia when compared to the control group (p < 0.001). Since heliox reduced infarct size and improved neurological deficit scores if initiated immediately after onset of ischemia, it may be a useful adjuvant to other stroke therapies.

Highlights

► Helium/oxygen protects the brain against acute focal ischemia stroke. ► 70%/30% helium/oxygen decreased infarct size and improved neurological outcome. ► Delayed treatment for 30–60 min resulted in a trend towards beneficial effects. ► 40%/30%/30% nitrogen/helium/oxygen was less effective than 70%/30% helium/oxygen.

Keywords: Helium; Heliox; Acute stroke; Transient focal ischemia; Rat model

Article Outline

Conflicts of interest

Acknowledgements

References

 



https://m.sciencenet.cn/blog-41174-444962.html

上一篇:氢气治疗视网膜病变
下一篇:现代版打鸡血

4 侯成亚 刘让华 郑永军 zhangling

发表评论 评论 (0 个评论)

数据加载中...
扫一扫,分享此博文

Archiver|手机版|科学网 ( 京ICP备07017567号-12 )

GMT+8, 2024-3-29 19:59

Powered by ScienceNet.cn

Copyright © 2007- 中国科学报社

返回顶部