Investigation of protective effect of hydrogen-rich water against cisplatininduced.pdf

    过去日本学者先后采用一般病理学和生物化学手段，CT等手段证明氢气能治疗经典化学治疗药物顺铂肾脏毒。现在他们又采用MRI的方法证明了同样的作用。

     注意他们采用的MRI是的BOLD加权，就是血红蛋白水平依赖的信号，这个信号过去比较经典的用途是研究脑功能，本质是测定血流的变化。因为当血流下降或升高后，局部静脉血的血氧含量相对发生改变，这种变化可以用MRI进行显示。研究通过对肾脏的功能，组织学，动物体重的进行了检测。全部都支持氢气对这个疾病的治疗作用。

Jpn J Radiol. 2011 Aug;29(7):503-12. Epub 2011 Sep 1.

Investigation of protective effect of hydrogen-rich water against cisplatininduced nephrotoxicity in rats using blood oxygenation level-dependent magnetic resonance imaging.

Matsushita T, Kusakabe Y, Kitamura A, Okada S, Murase K.

Source

Department of Medical Physics and Engineering, Division of Medical Technology and Science, Faculty of Health Science, Graduate School of Medicine, Osaka University, 1-7 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Abstract

PURPOSE:

The aim of this study was to assess the mechanism of the protective effect of hydrogen-rich water (HW) against cisplatin (CP)-induced nephrotoxicity in rats using blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI).

MATERIALS AND METHODS:

Apparent transverse relaxation time-weighted images (T2*WI) were acquired in 28 rats. The control group (n = 7) had free access to standard water (SW) and no CP injection. The CP group (n = 7) had free access to SW and was given a CP injection on day 0. The CP+HW group (n = 7) had free access to HW and had a CP injection. The HW group (n = 7) had free access to HW and no CP injection. The apparent transverse relaxation rate (R2*) was estimated from T2*WI.

RESULTS:

In the CP+HW group, the R2* value in the medulla normalized by the value of the day 0 was significantly greater than that in the CP group on days 4 and 7. The creatinine and blood urea nitrogen levels in the CP group were significantly higher than those in the control, CP+HW, and HW groups.

CONCLUSION:

BOLD MRI may be useful for demonstrating the change in R2* in CP-induced nephrotoxicity in rats. The changes in the CP+HW group were suspected to be due to a reduction of cytotoxic oxygen radicals.

PMID:

21882093

[PubMed - in process]