氢分子医学分享 http://blog.sciencenet.cn/u/孙学军 对氢气生物学效应感兴趣者。可合作研究:sunxjk@hotmail.com 微信 hydrogen_thinker

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生物材料镁释放氢气对肿瘤细胞作用的研究

已有 6621 次阅读 2013-9-9 15:42 |个人分类:氢气细胞学研究|系统分类:论文交流|关键词:学者

氢气的选择性抗氧化在生物医学领域已经受到广泛关注和认可,生物医学材料金属镁和水反应可以产生水,同时镁逐渐被腐蚀而被“消化”,镁离子也属于身体的重要金属元素。从这个角度考虑,金属镁作为骨骼、血管支架的可降解生物材料,具有特殊的优点。但是金属镁释放的氢气是否可以发挥生物学效应则需要研究确定,最近来自四川大学生物医学材料领域的学者用细胞学方法,证明金属镁和水反应产生的氢气可以中和骨恶性肿瘤细胞产生的活性氧,这种作用和氢气产生的速度有相关关系,研究提示金属镁生物材料在降解过程中释放的氢气或许可发挥治疗疾病的作用。文章在线发表在Journal of Biomedical Materials Research Part A。这是国际上首次用实验的方法证明金属镁通过释放氢气产生生物学效应的研究,过去曾经有学者用金属镁制备氢气水,研究氢气的生物学效应。

当然这是细胞学研究,细胞培养环境和机体的情况完全不同,这一推测需要动物实验来证明。作者认为氢气清除活性氧和抗肿瘤有关系的推测并不可靠,抗氧化不等于抗肿瘤效应,而且这种效应对放疗等治疗方法有可能具有对抗效应,也就是说帮助肿瘤细胞逃避药物和射线杀伤的作用。因此需要全面分析这个问题,不过这一研究也给氢气的细胞学研究提供了一种给气体的手段。但使用过程必须考虑金属镁腐蚀过程中对培养液中镁离子浓度的影响。

Reactive oxygen plays an important role in the pathogenesis of many serious illnesses, including bony cancer. Recently, it has been suggested that hydrogen (H2), a selective antioxidant, can effectively scavenge free radicals. Biomedical magnesium (Mg) used for bone defect repair in the surgery of bony cancer could release H2 because of the degradation, so Mg might have the potential to prevent bony cancer from metastasis and recurrence. In this study, alkali-heat treatment method was employed to modify the surface structure of Mg metal, so as to control the degradation of Mg metal and the H2 releasing rate. Then the released H2 was introduced to the Fenton Reaction system to detect its effect on scavenging free radicals. The modified Mg metal was employed as the substrate for bone cancer cell culture to study the effect of the H2 releasing on scavenging free radicals in the cells. It is found that the H2 released from the Mg degradation could scavenge free radicals both in the Fenton Reaction system and bone cancer cells. The effect on the scavenging free radical is proportional to the rate of H2 releasing. It suggested that Mg might be a potential material with anti-bone cancer properties. It is hopeful to both repair the bone defect and prevent bony cancer from metastasis and recurrence for the bony cancer patients by biomedical Mg metal.

 



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