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2022年12月嘲风作品集（二）

已有 924 次阅读 2023-2-27 17:08 |个人分类:作品发表|系统分类:论文交流

▲ Vol 09 Issue 35 | December 09 , 2022

Kartogenin-Conjugated Double-Network Hydrogel Combined with Stem Cell Transplantation and Tracing for Cartilage Repair

You-Rong Chen, Xin Yan, Fu-Zhen Yuan, Lin Lin, Shao-Jie Wang, Jing Ye, Ji-Ying Zhang, Meng Yang, De-Cheng Wu, Xing Wang, Jia-Kuo Yu

Cartilage Regeneration
PEG-CHI-KGN DN gel combined with peripheral blood-derived mesenchymal stem cells (PB-MSCs) is employed in treating knee cartilage defects. Compared with current tissue-engineering products, it has unique strength because of optimized mechanics, high biosafety, and a simple preparation process. PEG-CHI-KGN DN gel promote the chondrogenic differentiation and survival of allogenic PB-MSCs, ultimately enhancing cartilage regeneration and providing an innovative clinical treatment strategy from the tissue-engineering perspective. More details can be found in article number 2105571 by De-Cheng Wu, Xing Wang, Jia-Kuo Yu, and co-workers.

https://onlinelibrary.wiley.com/doi/10.1002/advs.202270225

▲ Vol 09 Issue 35 | December 12 , 2022

Osteogenic Differentiated Human Bone Marrow Stem Cells Contribute to Sprouting Angiogenesis Deceleration via Paracrine Excreted IGFBP7

Shiyu Sun, Cen Cao, Yaru Guo, Yi Hou, Yanze Meng, Yuman Li, Feng Mei, Zhewen Hu, Yao Li, Yuting Niu, Yiming Chen, Lili Chen, Ying Huang, Xuliang Deng

Sprouting Angiogenesis Deceleration
Deceleration of sprouting angiogenesis after vessel reconstruction is crucial for controlled tissue repair. As reported by Shiyu Sun, Cen Cao, and colleagues in article number 2201719, in bone defect healing, osteogenic-differentiated bone marrow stem cells contribute to sprouting angiogenesis deceleration by paracrine excreting insulin-like growth factor-binding protein 7 (IGFBP7), which inhibits sprouting angiogenesis by reducing cell migration and tip cell specification. This study suggests the potential therapeutic application of IGFBP7 in regulating vascular homeostasis.

https://onlinelibrary.wiley.com/doi/10.1002/admi.202270191

▲ Vol 12 Issue 47 | December 15 , 2022

Working Principles of Lithium Metal Anode in Pouch Cells

He Liu, Xin Sun, Xin-Bing Cheng, Cong Guo, Feng Yu, Weizhai Bao, Tao Wang, Jingfa Li, Qiang Zhang

Lithium Metal Batteries
Li metal batteries are considered to be important candidates for use in next-generation systems, including electric vertical take-off and landing, and even electric airplanes. In article number 2202518, Xin-Bing Cheng, Jingfa Li, Qiang Zhang, and co-workers present a comprehensive overview of the failure mechanism and regulation strategies of Li metal anodes in practical pouch cells. Dendrite growth is among the toughest issues in the pouch cell, which is one of the practical forms for the commercial applications of Li metal batteries.

https://onlinelibrary.wiley.com/doi/10.1002/aenm.202270199

▲ Vol 11 Issue 12 | December 16 , 2022

Two-Layered Microfluidic Devices for High-Throughput Dynamic Analysis of Synthetic Gene Circuits in E. coli

Yanhong Sun, Fengyu Zhang, Lusi Li, Kaiyue Chen, Shujing Wang, Qi Ouyang, and Chunxiong LuoQiang Zhang

Escherichia coli is a common chassis for synthetic gene circuit studies. In addition to the dose–response of synthetic gene circuits, the analysis of dynamic responses is also an important part of the future design of more complicated synthetic systems. Recently, microfluidic-based methods have been widely used for the analysis of gene expression dynamics. Here, we established a two-layered microfluidic platform for the systematic characterization of synthetic gene circuits (eight strains in eight different culture environments could be observed simultaneously with a 5 min time resolution). With this platform, both dose responses and dynamic responses with a high temporal resolution could be easily derived for further analysis. A controlled environment ensures the stability of the bacterial growth rate, excluding changes in gene expression dynamics caused by changes of the growth dilution rate. The precise environmental switch and automatic micrograph shooting ensured that there was nearly no time lag between the inducer addition and the data recording. We studied four four-node incoherent-feedforward-loop (IFFL) networks with different operators using this device. The experimental results showed that as the effect of inhibition increased, two of the IFFL networks generated pulselike dynamic gene expressions in the range of the inducer concentrations, which was different from the dynamics of the two other circuits with only a simple pattern of rising to the platform. Through fitting the dose–response curves and the dynamic response curves, corresponding parameters were derived and introduced to a simple model that could qualitatively explain the generation of pulse dynamics.

https://pubs.acs.org/doi/10.1021/acssynbio.2c00307

▲ Vol 61 Issue 51 | December 19 , 2022

An Enzymatically Gated Catalytic Hairpin Assembly Delivered by Lipid Nanoparticles for the Tumor-Specific Activation of Signal Amplification in miRNA Imaging

Dr. Qing Liu, Prof. Yuanyu Huang, Prof. Zhengping Li, Prof. Lele Li, Prof. Yuliang Zhao, Prof. Mengyuan Li

Tumor-specific miRNA imaging is achieved through the integration of enzyme-triggered catalytic hairpin assembly with lipid-nanoparticle-based delivery. The approach enables controlled activation of signal amplification in cancer cells with improved imaging contrast, as reported by Lele Li, Mengyuan Li, and co-workers in their Research Article (e202214230).

https://onlinelibrary.wiley.com/doi/10.1002/anie.202217291

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