Lithium and an EPAC-specific inhibitor ESI-09 synergistically suppress pancreatic cancer cell proliferation and survival Xinshuo Wang, Cheng Luo, Xiaodong Cheng, and Meiling Lu State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China, and Department of Integrative Biology and Pharmacology, Texas Therapeutics Institute, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, TX, USA Acta Biochim Biophys Sin 2017, 49: 573–580; doi: 10.1093/abbs/gmx045 Our previous studies showed that while lithium suppresses proliferation and induces apoptosis in pancreatic cancer cells, the inhibition of exchange proteins directly activated by cyclic adenosine monophosphate (cAMP) (EPAC)1 blocks pancreatic cancer cell migration and invasion. In this study, we further investigated the combinatory effects of lithium and EPAC-specific inhibitor (ESI)-09, an EPAC-specific inhibitor, on pancreatic cancer cell proliferation and viability, and explored whether lithium synergistically cooperates with EPAC inhibition in suppressing pancreatic cancer cell tumorigenicity. The cell viability of pancreatic cancer cell lines PANC-1 and MiaPaCa-2 was measured after 48 h of incubation with different dose combination of lithium and ESI-09. Flow cytometric analysis was carried out to further verify the impact of lithium and ESI-09 upon PANC-1 cell proliferation and apoptosis. To investigate the mechanism that the effects generated by lithium and ESI-09 on PANC-1 cells, the intracellular cAMP level was measured by an ELISA-based cAMP immunoassay. Our data showed that lithium and ESI-09 synergistically inhibit pancreatic cancer cell growth and survival. Furthermore, our results revealed a novel mechanism in which the synergism between lithium and ESI-09 is not mediated by the inhibitory effect of lithium toward GSK3β, but by lithium's ability to suppress cAMP/protein kinase A signaling. Combination of LiCl and ESI-09 inhibited the cell proliferation of PANC-1 cells 阅读原文: http://www.abbs.org.cn/arts.asp?id=4172 获取全文: abbs@sibs.ac.cn 相关论文: 1 Epac proteins: multi-purpose cAMP targets 2 Epac : Defining a New Mechanism for cAMP Action 3 A novel Epac -specific cAMP analogue demonstrates independent regulation of Rap1 and ERK 4 The future of EPAC -targeted therapies: agonism versus antagonism 5 Role of Epac2A/Rap1 Signaling in Interplay Between Incretin and Sulfonylurea in Insulin Secretion 6 A Novel EPAC -Specific Inhibitor Suppresses Pancreatic Cancer Cell Migration and Invasion 7 Growth inhibitory effect of lithium gammalinolenate on pancreatic cancer cell lines: The influence of albumin and iron 8 In vivo and in vitro biotransformation of the lithium salt of gamma-linolenic acid by three human carcinomas
ACS Energy Lett., 2017 , 2 , pp 111–116 DOI: 10.1021/acsenergylett.6b00582 Publication Date (Web): December 9, 2016 http://pubs.acs.org/doi/abs/10.1021/acsenergylett.6b00582 Interconnected Ni(HCO 3 ) 2 Hollow Spheres Enabled by Self-Sacrificial Templating with Enhanced Lithium Storage Properties Shiqiang Zhao , Zewei Wang , Yanjie He , Beibei Jiang , Yeuwei Harn , Xueqin Liu , Faqi Yu , Fan Feng , Qiang Shen * , and Zhiqun Lin * Key Laboratory for Colloid and Interface Chemistry of Education Ministry, School of Chemistry and Chemical Engineering, Shandong University , Jinan 250100, PR China School of Materials Science and Engineering, Georgia Institute of Technology , Atlanta, Georgia 30332, United States Interconnected nickel bicarbonate (Ni(HCO 3 ) 2 ) hollow spheres were produced and exploited for the first time as an anode of lithiumion batteries, delivering the 80 th reversible capacityof 1442 mAh g -1 at the current rate of 100 mAg -1 which is 3.9 times the theoretical capacityof commercial anode graphite . The time-dependent study suggested a self-sacrificialtemplating formation mechanism that yielded such intriguing interconnectedhollow structure s. X-r ay photoelectron spectroscopy(XPS) measurements on cycled electrodes indicated thatboth the deep oxidation of Ni 2+ into Ni 3+ and thereversible reactions in HCO 3 - accounted for the ultrahighcapacity of Ni(HCO 3 ) 2 in comparison to its generally accepted theoretical capacity of 297 mAh g -1 . Morphological characterizations revealedthat the interconnected hollow structure s enabled the enhancedrate performance and cycling stability due to their large contact areas with electrolyte andbetter buffering effect to accommodate the volume change compared to the solidcounterpart. 文章PDF: Ni(HCO3)2 for LIB-MS-ACS Energy Lett., 2017, 2, pp 111–116.pdf Ni(HCO3)2 for LIB-SI-ACS Energy Lett., 2017, 2, pp 111–116.pdf
Cobalt carbonate （CoCO3）dumbbells for high-capacity lithium storage: A slight doping of ascorbic acid and an enhancement in electrochemical performances http://www.sciencedirect.com/science/article/pii/S0378775315004322 doi:10.1016/j.jpowsour.2015.03.016 Shiqiang Zhao, Shanshan Wei, Rui Liu, Yuxi Wang, Yue Yu, Qiang Shen Journal of Power Sources 284 (2015) 154-161 h i g h l i g h t s CoCO3 dumbbells are hydrothermally synthesized in the presence of ascorbic acid. The crystallization and aggregation of CoCO3 are greatly modified by ascorbic acid. Ascorbic acid doped CoCO3 dumbbells exhibit enhanced electrochemical performances. The 100th discharge capacity is as high as 1042 mAh g-1 at 200 mA g-1. g r a p h i c a l a b s t r a c t a b s t r a c t Synthesis of materials with desirable nanostructures is a hot research topic owing to their enhanced performances in contrast to the bulk counterparts. Herein, dumbbell-shaped cobalt carbonate (CoCO3) nano architectures and the bulk counterpart of CoCO3 rhombohedra are prepared via a facile hydrothermal route in the presence and absence of ascorbic acid (AA), respectively. By comparison, it has been found that: the addition of AA in the hydrothermal crystallization system changes the shape of the building blocks from Co2CO3(OH)2 nanosheets to CoCO3 nanoparticles, and then further influences the final configuration of the products. When applied as anodes of lithium ion batteries, CoCO3 dumbbells deliver a 100th capacity of 1042 mAh g1 at 200 mA g1 and even exhibit a long-term value of 824 mAh g1 over 500 cycles at 1000 mA g1, which are much higher than the rhombohedral counterparts with corresponding 540 and 481 mAh g1 respectively. The much higher capacity, better cycling stability and enhanced rate performance of CoCO3 dumbbells can be attributed to the higher specific surface area, smaller charge transport resistance and better structure stability resulting from the slight doping (~4.6 wt%) of AA, and also relate with a novel lithium storage mechanism in CoCO3. JPS CoCO3(2015).pdf
Hydrothermal synthesis and potential applicability of rhombohedral siderite as a high-capacity anode material for lithium ion batteries Shiqiang Zhao, Yue Yu, Shanshan Wei, Yuxi Wang, Chenhao Zhao, Rui Liu, Qiang Shen* Journal of Power Sources 253 (2014) 251-255 2014.5.1-赵世强-journal of power sources .pdf http://www.sciencedirect.com/science/article/pii/S0378775313020338 DOI: 10.1016/j.jpowsour.2013.12.055 a b s t r a c t Natural siderite is a valuable iron mineral composed of ferrous carbonate (FeCO 3 ), which is commonly found in hydrothermal veins and contains no sulfur or phosphorus. In this paper, micro-sized FeCO 3 crystallites are synthesized via a facile hydrothermal route, and almost all of them possess a rhombohedral shape similar to that of natural products. When applied as an anode material for lithium ion batteries, the synthetic siderite can deliver an initial specific discharge capacity ofw1587 mAh g -1 with a coulombic efficiency of 68% at 200 mA g -1 , remaining a reversible value of 1018 mAh g -1 over 120 cycles. Even at a high current density of 1000 mA g -1 , after 120 cycles the residual specific capacity (812 mAh g -1 ) is still higher than the theoretical capacity of FeCO3 (463 mAh g -1 ). Moreover, a novel reversible conversion mechanism accounts for the excellent electrochemical performances of rhombohedral FeCO3 to a great extent, implying the potential applicability of synthetic siderite as lithium ion battery anodes. 2013 Elsevier B.V. All rights reserved. Keywords: Lithium ion battery Anode material Hydrothermal synthesis Ferrous carbonate Rhombohedral crystallite 4. Conclusions Rhombohedral FeCO 3 (or synthetic siderite) has been facilely synthesized by a hydrothermal method, possessing an average size of 1.4±0.2 mm. Tentatively applied as LIB anodes, the excellent durability and high-rate performance of these micro-rhombohedra can be reproducibly observed. Even at 1000 mA g -1 , the reversible capacity (w800 mAh g -1 ) is still higher than the theoretical capacity of FeCO 3 (463 mAh g -1 ). As for the novel electrochemical activity of FeCO 3 towards metal lithium, the simultaneous formation of unknown Fe 3 + -containing derivatives and possible C - 1 -containing Li 2 C 2 incompletely answers the high-capacity characteristics of FeCO 3 (e.g., the 120th reversible value w1000 mAh g -1 at 200 mA g -1 ). Therefore, the lithium storage mechanism of FeCO 3 needs to be further conducted in future.
锂离子电池是电子行业领域最关键的技术之一，可以说是支撑电子、信息产业等发展的关键环节之一！ 上世纪九十年代初，锂离子电池在日本商业化以来，电极材料的更新换代推动着锂电技术的发展，开发新的电极材料成为推动锂电技术的关键！ 目前被开发利用的锂离子电池电极材料主要有： 正极材料：钴酸锂、锂锰氧、镍酸锂、三元系、磷酸铁锂、硅酸铁锂等，负极材料：石墨、 Sn 氧化物、 Co 氧化物、 Si 、 Ge 以及新近的碳管负极材料等，而由于矿物资源的缺乏，磷酸铁锂、硅酸铁锂等正极材料被研究人员广泛研究，对于负极材料，新近研究较多的则是氧化物、 Si 、碳管负极材料。 锂电正极材料目前主要的是如何提高倍率性能，大电流放电技术是其广泛应用于电动汽车等动力型电池技术领域的关键，目前较有希望的正极材料则是由 Goodenough 在 1997 年发现的锂铁磷酸盐，这种橄榄石型结构的材料，脱嵌 Li 后材料的晶体结构仍为橄榄石型的 FePO4 ，结构稳定，安全性能高，不足之处主要在于其电导率较低，因此如何提高其电导率是其性能提升的最关键，因而，科研人员对其掺杂与碳包覆被用来提升其电化学性能！然而这两种方法改进性能的同时，则不同程度的破坏了其晶体结构，因此，探索新的方法改进性能将是未来研究的重点。日前，有日本学者报道，采用聚合限制法制备得到的纳米晶 LiFePO4 ，尺寸在 30 40nm ，得其 50C 下容量为 90mAh/g ，而韩国学者则在 10C 下得到容量超过 150mAh/g ，表现出较好的高倍率性能。 对于负极材料，商业化的石墨容量偏低，而新的负极材料目前虽然具有较高的理论容量，但是其稳定性不高，容量衰减很快，目前报道的高容量、高稳定性的新型负极材料合成条件苛刻，成本高，仅仅停留在实验室阶段，如斯坦福大学的 Cui 报道的 Si 纳米线电极，虽然其容量接近理论容量，但是其制备采用 CVD 沉积技术，对于工业化则其成本偏高，金属氧化物负极材料，则尚处在微观结构和形貌控制的 Papers 中间，前途未得而知。而碳管负极，虽然最近研究比较热烈，但是其容量衰减快而碳管大规模生产成本还是偏高，因此更新尚未完成，同志任需努力！ 如上仅为一些浅显见解，如有不当之处，还请诸位大家见谅并指出，小生当感激不尽！ Y. G. Wang, Y. R. Wang, H. S. Zhou, et al. Angew. Chem. Int. Ed. 2008, 47, 1 6 S. Y. Lim, C. S. Yoon and J. P. Cho. Chemistry of Materials, 20(14):4560-4564 ,2008.
Introduction New Energy and Material Chemistry laboratory in INET, Tsinghua University was established in 1996. There are now more than 60 members in the laboratory, including 1 academician, 3 professors, 4 associate professors, 2 senior engineer, 8 assistant professors, 12 technicians and more than 30 graduate students. The RD activities of laboratory are mainly focused on the engineering and engineering fundamentals of advanced materials, core components and system integration in the areas of fuel cells and lithium ion batteries, which can be used as portable and stationary power sources, due to their high energy density, long lifetime, environmental benign. A fruits of achievements on fuel cell and lithium ion battery materials have been acquired. High level specialists and experts in the fields of electrochemistry, chemical engineering, materials science, and catalysis have been cultivated in order to make a valuable contribution to the economic construction and sustainable social development of the country. Research Fields The Research fields conducted in the laboratory comprise fuel cell, hydrogen energy, lithium ion batteries and Electrochemical Capacitor. Fuel cell stack; Fuel cell bipolar plate Advanced electrode and electrolyte materials Design and integration of stacks and power generation systems Modeling calculation and computer simulation of fuel cell and lithium ion battery Diagnosis and control of system Direct methanol fuel cells(DMFCs) Electrochemical Capacitors Nano materials for energy conversion and storage Oxide cathode materials for lithium ion batteries Alloy anode materials for lithium ion batteries Polymer materials for lithium ion batteries Lithium sulfur batteries
标签: lithium
