宾夕法尼亚大学医学院的研究人员在新研究中发现了一条从前未知的生物信号通路在男性脱发中发挥了重要作用。相关研究论文发表在3月21日的《科学转化医学》（Science Translational Medicine）杂志上，作者们在文章中指出一种称为前列腺素D2(PGD2)的脂质复合物抑制了头发的生长。 http://www.ebiotrade.com/newsf/2012-3/2012322133939440.htm http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi Start A-Literature C-Literature B-list Filter Literature A-query: Prostaglandin D2 前列腺素D2 C-query: Hair Growth 毛发生长 The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 1 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here . The results of this search are saved under id # 14952 and can be accessed from the start page after you leave this session. There are 552 terms on the current B-list (发现这两者研究文献中的基因与遗传学知识概念120个 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin. To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/view_b_txt.cgi?ID=14952 job id # 14952 started Thu Mar 22 20:05:23 2012 Max_citations: 50000 Stoplist: /var/www/html/arrowsmith_uic/data/stopwords_pubmed Ngram_max: 3 A_query_raw: Prostaglandin D2Thu Mar 22 20:05:34 2012 A query = Prostaglandin D2 started Thu Mar 22 20:05:35 2012 A query resulted in 3859 titles C_query_raw: Prostaglandin D2 Thu Mar 22 20:05:39 2012 C: Prostaglandin D2 3859 A: pubmed_query_A 3859 AC: ( Prostaglandin D2 ) AND ( Prostaglandin D2 ) 3859 C_query_raw: Hair Growth Thu Mar 22 20:05:48 2012 C: Hair Growth 10758 A: pubmed_query_A 3859 AC: ( Prostaglandin D2 ) AND ( Hair Growth ) 1 C_query_raw: Hair Growth Thu Mar 22 20:05:55 2012 C: Hair Growth 10758 A: pubmed_query_A 3859 AC: ( Prostaglandin D2 ) AND ( Hair Growth ) 1 C query = Hair Growth started Thu Mar 22 20:05:56 2012 C query resulted in 10758 titles A AND C query resulted in 1 titles 5330 B-terms ready on Thu Mar 22 20:07:46 2012 Sem_filter: Genes Molecular Sequences, and Gene Protein Names 552 B-terms left after filter executed Thu Mar 22 20:11:42 2012 B-list on Thu Mar 22 20:14:44 2012 1 vegf 2 akt 3 stat3 4 cox-2 5 smad 6 signal regulated kinase 7 ppar alpha 8 c kit 9 smad2 10 sox9 11 sonic hedgehog 12 map kinase 13 ppar 14 jnk 15 pten 16 chemokine 17 nf kappab 18 kit ligand 19 bdnf 20 n myc 21 estrogen receptor alpha 22 ccaat enhancer binding 23 hepatocyte growth factor 24 retinoic acid receptor 25 phosphatidylinositol 3-kinase 26 defensin 27 mek 28 c ebp 29 transcription factor 30 cd133 31 retinoblastoma protein 32 rankl 33 rxr 34 tgf beta 35 mitf 36 leptin 37 tgf beta1 38 pi3k 39 cyclin dependent kinase 40 neurotrophin 41 estrogen receptor beta 42 fk506 43 c myc 44 cyclin d1 45 bax 46 pparalpha 47 single nucleotide polymorphism 48 cd40 49 nude 50 rac1 51 glutathione s transferase 52 ngf 53 hif-1 54 activin 55 nadph oxidase 56 bcl-2 57 pthrp 58 myc 59 peroxisome 60 kruppel 61 gene promoter 62 kruppel factor 63 caspase 64 matrix metalloproteinase 65 potassium channel 66 cadherin 67 polycystic ovary syndrome 68 cdna 69 b16 70 survivin 71 candidate gene 72 hairless 73 tyrosine kinase 74 il-8 75 gata-3 76 histone deacetylase 77 enhancer 78 bfgf 79 bcl xl 80 erbb 81 aromatase 82 epidermal growth factor 83 e knockout mice 84 gene encoding 85 cytokine 86 ifn gamma 87 cyclin 88 tnf alpha 89 gata3 90 erk 91 chop 92 e cadherin 93 insulin growth factor 94 nf 95 p27 96 promoter activity 97 clusterin 98 estrogen receptor 99 statin 100 ornithine decarboxylase 101 mmp-9 102 mip-2 103 receptor gene 104 rho kinase 105 protein kinase c 106 hedgehog 107 calcitonin gene related 108 tgfbeta 109 gene related peptide 110 egfr 111 kit 112 nf kappa b 113 receptor tyrosine kinase 114 phospholipase d 115 protooncogene 116 p21 117 tenascin c 118 factor gene 119 phospholipase 120 sirt1 http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/show_sentences.cgi Start A-Literature C-Literature B-list Filter Literature AB literature B-term BC literature Prostaglandin D2 vegf Hair Growth 1: PPAR-gamma agonists induce the expression of VEGF and its receptors in cultured cardiac myofibroblasts.2007 Add to clipboard 2: Effects of 15d-PGJ(2) on VEGF -induced angiogenic activities and expression of VEGF receptors in endothelial cells.2006 Add to clipboard 3: Upregulation of VEGF by 15-deoxy-Delta12,14-prostaglandin J2 via heme oxygenase-1 and ERK1/2 signaling in MCF-7 cells.2006 Add to clipboard 4: Opposite effects of prostaglandin-J2 on VEGF in normoxia and hypoxia: role of HIF-1.2004 Add to clipboard 5: Rapid change of glucose concentration promotes mesangial cell proliferation via VEGF : inhibitory effects of thiazolidinedione.2004 Add to clipboard 6: Effect of prostaglandin-J(2) on VEGF synthesis depends on the induction of heme oxygenase-1.2002 Add to clipboard 1: The anti-proliferative side effects of AEE788, a tyrosine kinase inhibitor blocking both EGF- and VEGF -receptor, are liver-size-dependent after partial hepatectomy in rats.2010 Add to clipboard 2: Erythropoietin but not VEGF has a protective effect on auditory hair cells in the inner ear.2009 Add to clipboard 3: Fast alterations of vascular endothelial growth factor (VEGF ) expression and that of its receptors (Flt-1, Flk-1 and Neuropilin) in the cochlea of guinea pigs after moderate noise exposure.2007 Add to clipboard 4: Vascular endothelial growth factor (VEGF ) expression in noise-induced hearing loss.2006 Add to clipboard 5: 2002 Add to clipboard 6: Control of hair growth and follicle size by VEGF -mediated angiogenesis.2001 Add to clipboard 7: Immunohistochemical detection of vascular endothelial growth factor (VEGF ) and VEGF receptors Flt-1 and KDR/Flk-1 in the cochlea of guinea pigs.2001 Add to clipboard 8: The role of VEGF and thrombospondins in skin angiogenesis.2000 Add to clipboard 9: Anti-androgens and estrogens: modulators of VEGF expression in cultured hair dermal papilla cells.1999 Add to clipboard 10: Expression of vascular endothelial growth factor (VEGF ) in various compartments of the human hair follicle.1998 Add to clipboard 11: 1998 Add to clipboard 12: Inhibitory effects of bFGF, VEGF and minoxidil on collagen synthesis by cultured hair dermal papilla cells.1996 Add to clipboard 13: Vascular endothelial cells: targets for studying the activity of hair follicle cell-produced VEGF .1996 Add to clipboard
标签: 前列腺素
