http://www.nature.com/nm/focus/pain/index.html Focus on Pain Focus issue: November 2010 Volume 16 , 11 11 Reviews Sponsor Introduction News The articles in this collection review our progress in understanding the neurobiological basis of pain and the challenges to translate these advances into new analgesics. Top of page Introduction Focus on Pain Pain, from bench to bedside There has been substantial progress in understanding the neurobiological basis of pain, but these advances have yet to translate into new and improved analgesics. Published online: 14October2010 | :10.1038/nm1110-1236 :10.1038/nm1110-1236 Abstract - | Full Text - Pain, from bench to bedside | (60 ) (60 ) Top of page News Focus on Pain Animalgesic effects Elie Dolgin Published online: 14October2010 | :10.1038/nm1110-1237 :10.1038/nm1110-1237 Animal experiments have produced an explosion of information about pain, but this knowledge has failed to yield new painkillers for use in humans. This abysmal track record has led to calls to overhaul the design of preclinical studies. Elie Dolgin goes to great pains to learn how monitoring rodents' facial expressions and brain activity might offer a more effective and humane way to test drug candidates. Abstract - | Full Text - Animalgesic effects | (1,380 ) (1,380 ) Top of page Reviews Focus on Pain Advances in clinical research methodology for pain clinical trials John T Farrar Published online: 14October2010 | :10.1038/nm.2249 :10.1038/nm.2249 Abstract - | Full Text - Advances in clinical research methodology for pain clinical trials | (382 ) (382 ) Focus on Pain Nociceptor sensitization in pain pathogenesis Michael S Gold Gerald F Gebhart Published online: 14October2010 | :10.1038/nm.2235 :10.1038/nm.2235 Abstract - | Full Text - Nociceptor sensitization in pain pathogenesis | (1,776 ) (1,776 ) Focus on Pain Central mechanisms of pathological pain Rohini Kuner Published online: 14October2010 | :10.1038/nm.2231 :10.1038/nm.2231 Abstract - | Full Text - Central mechanisms of pathological pain | (1,352 ) (1,352 ) Focus on Pain Interactions between the immune and nervous systems in pain Ke Ren Ronald Dubner Published online: 14October2010 | :10.1038/nm.2234 :10.1038/nm.2234 Abstract - | Full Text - Interactions between the immune and nervous systems in pain | (1,414 ) (1,414 ) Focus on Pain Getting the pain you expect: mechanisms of placebo, nocebo and reappraisal effects in humans Irene Tracey Published online: 14October2010 | :10.1038/nm.2229 :10.1038/nm.2229 Abstract - | Full Text - Getting the pain you expect: mechanisms of placebo, nocebo and reappraisal effects in humans | (664 ) (664 ) Focus on Pain Overcoming obstacles to developing new analgesics Clifford J Woolf Published online: 14October2010 | :10.1038/nm.2230 :10.1038/nm.2230 Abstract - | Full Text - Overcoming obstacles to developing new analgesics | (559 ) (559 ) http://www.gopubmed.org/web/gopubmed/1?WEB1mOWEB10O00d000j10020001000h00100090000 2,157 documents semantically analyzed 1 2 3 Top Years Publications 2008 199 2009 197 2007 180 2006 161 2010 145 2005 136 2003 132 2004 121 2002 100 2001 88 2000 83 1999 64 1998 61 1997 53 1996 51 1994 50 1995 49 1991 35 1993 34 1990 27 1 2 3 1 2 3 4 Top Countries Publications USA 566 Japan 144 Italy 126 Germany 125 United Kingdom 95 France 79 Turkey 61 Canada 60 Spain 51 China 49 India 44 Brazil 40 Netherlands 31 South Korea 30 Switzerland 30 Sweden 30 Denmark 27 Australia 23 Israel 22 Greece 19 1 2 3 4 1 2 3 ... 32 Top Cities Publications Boston 33 London 32 Ankara 26 Philadelphia 20 Milan 20 Rome 19 Baltimore 18 New York City 18 Seoul, South Korea 17 Chicago 17 Tokyo 16 Barcelona 16 Paris 16 Cleveland 15 Houston 15 Toronto 15 Berlin, Germany 13 Minneapolis 13 New Delhi 13 San Diego 12 1 2 3 ... 32 1 2 3 ... 46 Top Journals Publications Pain 74 Eur J Pharmacol 35 Arzneimittel-forsch 26 Anesth Analg 25 J Pharmacol Exp Ther 25 Anesthesiology 21 Gan To Kagaku Ryoho 20 Spine 19 Eur J Pain 15 J Clin Oncol 15 Brit J Pharmacol 15 Ann Pharmacother 13 Am J Gastroenterol 13 Deut Med Wochenschr 13 J Neurosci 12 Pain Med 12 J Pain Symptom Manag 12 Neuroscience 11 Brain Res 11 Life Sci 11 1 2 3 ... 46 1 2 3 ... 422 Top Terms Publications Humans 1,611 Patients 1,118 Analgesics 997 Pain 729 Middle Aged 695 Animals 675 Adult 639 Anti-Inflammatory Agents, Non-Steroidal 576 Pain Measurement 536 Pharmaceutical Preparations 534 Aged 521 Anti-Inflammatory Agents 428 Evaluation Studies as Topic 427 Rats 402 Analgesics, Opioid 400 Diagnosis 323 Inflammation 318 Treatment Outcome 292 Morphine 268 Mice 239 1 2 3 ... 422 1 2 3 ... 451 Top Authors Publications Ye?ilada E 8 Serhan C 8 Granados-Soto V 7 Kpeli E 6 Ferreira S 6 Stein C 6 Lipton A 6 Mantyh P 5 Mousa S 5 Suzuki T 5 Schafer M 5 Yaksh T 5 Gronert K 5 Eisenach J 5 Bruera E 5 Besson J 5 Svensson C 4 Jensen T 4 Honore P 4 Porreca F 4 1 2 3 ... 451
西班牙 Escalante Y 等于 2010 年 1 月的 J Back Musculoskelet Rehabil (腰背及肌肉骨骼康复)杂志上撰文,回顾了体育锻练与成人下肢骨性关节炎疼痛缓解。 文中称: 骨性关节炎是一种退变性关节疾病。 膝关节和髋关节最容易发生骨性关节炎。 治疗方法主要分为 3 类:药物疗法、非药物疗法、手术疗法。 这三类疗法可以单独使用,也可以联合使用。 在过去的几年间,在非药物疗法中,人们发现体育锻练可能减轻膝关节和髋关节得疼痛。 本系统回顾的目的就是总结在减轻膝关节疼痛和髋关节疼痛中体育锻练有效性的证据及体育锻练的具体方案。 本文主要结论如下: 1 、虽然说体育锻练被推荐应用于减轻膝关节骨性关节炎及髋关节骨性关节炎患者的疼痛,但是还几乎没有谁进行过随机的临床研究。 2 、各种体育锻练方案(具体内容、持续时间、频率、间隔时间)差异很大。 3 、总的来说,基于太极的体育锻练比其它混合型的体育锻练项目有更好的效果,但是还没有发现有明显的差异性。 J Back Musculoskelet Rehabil. 2010 Jan 1;23(4):175-86. Physical exercise and reduction of pain in adults with lower limb osteoarthritis: A systematic review. Escalante Y , Saavedra JM , Garca-Hermoso A , Silva AJ , Barbosa TM . Facultad de Ciencias del Deporte, AFIDES Research Group, Universidad de Extremadura, Spain. 启发:膝关节骨性关节炎患者膝关节疼痛。如何进行体育锻练从而缓解膝关节疼痛呢?太极拳也许可以帮助我们的膝关节骨性关节炎患者减轻疼痛。但是疗效是否确切?适合哪一类人群?锻练的时间长短?锻练的间隔时间长短?这些都是我们今后需要进一步观察和研究的问题。 江苏省徐州医学院附属医院骨科 膝关节方向 高绪仁 编译