原创博文，不许转载。 知识发现与数据挖掘的关系 http://blog.sciencenet.cn/blog-280034-600896.html 最新研究动态： Rapamycin（雷帕霉素）能减轻年龄相关肥胖症状，这一过程与下丘脑前阿黑皮素原神经元中mTOR信号增加有关。 http://www.ebiotrade.com/newsf/2012-8/20128993434262.htm 雷帕霉素（Rapamycin）最先是从东南太平洋上的一个小岛——复活岛的土壤样本中发现的一种细菌产生，自20世纪70年代开发出来便经常作为免疫抑制剂用于器官移植，以减缓器官移植手术后的免疫排斥反应，特别是肾移植。 检索策略： A-query: Rapamycin C-query: Obesity 知识发现结果： The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 236 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here . The results of this search are saved under id # 11025 and can be accessed from the start page after you leave this session. There are 1399 terms on the current B-list (雷帕霉素与肥胖研究的知识发现249个与基因相关知识概念，对科研选题与进行中的科研工作有一定参考价值 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin. To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms. 知识发现平台： http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/start.cgi mTOR信号通路是调控细胞生长与增殖的一个关键通路，该通路将从营养分子、能量状态以及生长因子传来的信号整合在一起，调控大量的生命过程，包括自我吞噬、核糖体的生物组合和代谢等。该通路的失调与多种人类疾病相关，包括癌症、糖尿病与心血管疾病。 Start A-Literature C-Literature B-list Filter Literature AB literature B-term BC literature Rapamycin mtor Obesity 1: The Role of mTOR Inhibitors for the Treatment of B-Cell Lymphomas.2012 Add to clipboard 2: Programmed cell death 6 (PDCD6) inhibits angiogenesis through PI3K /mTOR /p70S6K pathway by interacting of VEGFR-2.2012 Add to clipboard 3: Insulin-induced mTOR activity exhibits anti-hepatitis C virus activity.2012 Add to clipboard 4: Leucine and arginine regulate trophoblast motility through mTOR -dependent and independent pathways in the preimplantation mouse embryo.2012 Add to clipboard 5: mTOR -rictor is the Ser(473) kinase for AKT1 in mouse one-cell stage embryos.2012 Add to clipboard 6: The PTPN11 loss-of-function mutation Q510E-Shp2 causes hypertrophic cardiomyopathy by dysregulating mTOR signaling.2012 Add to clipboard 7: Current development of the second generation of mTOR inhibitors as anticancer agents.2012 Add to clipboard 8: CYR61 controls p53 and NF-kappaB expression through PI3K/Akt /mTOR pathways in carboplatin-induced ovarian cancer cells.2012 Add to clipboard 9: Temsirolimus, an mTOR inhibitor, in combination with lower-dose clofarabine as salvage therapy for older patients with acute myeloid leukaemia: results of a phase II GIMEMA study (AML-1107).2012 Add to clipboard 10: Biochemical and pharmacological inhibition of mTOR by rapamycin and an ATP-competitive mTOR inhibitor.2012 Add to clipboard 11: mTOR activity under hypoxia.2012 Add to clipboard 12: Isolation of the mTOR complexes by affinity purification.2012 Add to clipboard 13: Detection of cytoplasmic and nuclear functions of mTOR by fractionation.2012 Add to clipboard 14: Evaluation of mTOR -regulated mRNA translation.2012 Add to clipboard 15: Quantitative visualization of autophagy induction by mTOR inhibitors.2012 Add to clipboard 16: Expanding human T regulatory cells with the mTOR -inhibitor rapamycin .2012 Add to clipboard 17: Utilizing a retroviral RNAi system to investigate in vivo mTOR functions in T cells.2012 Add to clipboard 18: Exploring functional in vivo consequences of the selective genetic ablation of mTOR signaling in T helper lymphocytes.2012 Add to clipboard 19: Evaluating the therapeutic potential of mTOR inhibitors using mouse genetics.2012 Add to clipboard 20: Inhibition of PI3K-Akt -mTOR signaling in glioblastoma by mTOR C1/2 inhibitors.2012 Add to clipboard 21: Assessing the function of mTOR in human embryonic stem cells.2012 Add to clipboard 22: Development of ATP-competitive mTOR inhibitors.2012 Add to clipboard 23: mTOR inhibitor-associated proteinuria in kidney transplant recipients.2012 Add to clipboard 24: Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks.2012 Add to clipboard 25: The role of mTOR signaling in Alzheimer disease.2012 Add to clipboard 26: mTOR as a Target of Everolimus in Refractory/Relapsed Hodgkin Lymphoma.2012 Add to clipboard 27: Kinome-wide selectivity profiling of ATP-competitive mTOR (mammalian target of rapamycin ) inhibitors and characterization of their binding kinetics.2012 Add to clipboard 28: Analysis of the pharmacodynamic activity of the mTOR inhibitor ridaforolimus (AP23573, MK-8669) in a phase 1 clinical trial.2012 Add to clipboard 29: Pentylenetetrazole-induced seizures cause acute, but not chronic, mTOR pathway activation in rat.2012 Add to clipboard 30: Immunohistochemical analysis of the mTOR pathway in intrahepatic cholangiocarcinoma.2012 Add to clipboard 31: miR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1.2012 Add to clipboard 32: A Novel Application of Topical Rapamycin Formulation, an Inhibitor of mTOR , for Patients With Hypomelanotic Macules in Tuberous Sclerosis Complex.2012 Add to clipboard 33: Systemic Bisperoxovanadium Activates Akt /mTOR , Reduces Autophagy, and Enhances Recovery following Cervical Spinal Cord Injury.2012 Add to clipboard 34: HIV-1 Promotes Renal Tubular Epithelial Cell Protein Synthesis: Role of mTOR Pathway.2012 Add to clipboard 35: Roles of the mammalian target of rapamycin , mTOR , in controlling ribosome biogenesis and protein synthesis.2012 Add to clipboard 36: mTOR inhibitors in cancer therapy.2012 Add to clipboard 37: mTOR -independent 4E-BP1 phosphorylation is associated with cancer resistance to mTOR kinase inhibitors.2012 Add to clipboard 38: The progesterone-induced enhancement of object recognition memory consolidation involves activation of the extracellular signal-regulated kinase (ERK) and mammalian target of rapamycin (mTOR ) pathways in the dorsal hippocampus.2012 Add to clipboard 39: Drug Interaction Between Cyclosporine and mTOR Inhibitors in Experimental Model of Chronic Cyclosporine Nephrotoxicity and Pancreatic Islet Dysfunction.2012 Add to clipboard 40: Altered mTOR signaling and enhanced CYFIP2 expression levels in subjects with Fragile X syndrome.2012 Add to clipboard 41: AKT /mTOR activation induces a module of metabolic changes contributing to growth in insulin-induced hepatocarcinogenesis.2012 Add to clipboard 42: PI3K/AKT /mTOR Inhibitors in Patients With Breast and Gynecologic Malignancies Harboring PIK3CA Mutations.2012 Add to clipboard 43: Role of mTOR in neuroprotection and axon regeneration after inflammatory stimulation.2012 Add to clipboard 44: Mycobacterial induction of autophagy varies by species and occurs independently of mTOR inhibition.2012 Add to clipboard 45: Improved insulin sensitivity by rapamycin is associated with reduction of mTOR and S6K1 activities in L6 myotubes.2012 Add to clipboard 46: mTOR Inhibitors and its Role in the Treatment of Head and Neck Squamous Cell Carcinoma.2012 Add to clipboard 47: Sustained antitumor activity by co-targeting mTOR and the microtubule with temsirolimus/vinblastine combination in hepatocellular carcinoma.2012 Add to clipboard 48: Deregulated mTOR -mediated translation in intellectual disability.2012 Add to clipboard 49: Hypothalamic mTOR pathway mediates thyroid hormone-induced hyperphagia in hyperthyroidism.2012 Add to clipboard 50: GSK2126458 and GSK2126458, the first radiosynthesis of new potential PET agents for imaging of PI3K and mTOR in cancers.2012 Add to clipboard 51: Isoleucine and Leucine Independently Regulate mTOR Signaling and Protein Synthesis in MAC-T Cells and Bovine Mammary Tissue Slices.2012 Add to clipboard 52: The PI3-Kinase /mTOR -Targeting Drug NVP-BEZ235 Inhibits Growth and IgE-Dependent Activation of Human Mast Cells and Basophils.2012 Add to clipboard 53: Arrest of Myelination and Reduced Axon Growth When Schwann Cells Lack mTOR .2012 Add to clipboard 54: Inhibition of tumor cell growth, proliferation and migration by X-387, a novel active-site inhibitor of mTOR .2012 Add to clipboard 55: Remarkable inhibition of mTOR signaling by the combination of rapamycin and 1,4-phenylenebis(methylene)selenocyanate in human prostate cancer cells.2012 Add to clipboard 56: Rapamycin toxicity in MIN6 cells and rat and human islets is mediated by the inhibition of mTOR complex 2 (mTOR C2).2012 Add to clipboard 57: mTOR inhibition with rapamycin causes impaired insulin signalling and glucose uptake in human subcutaneous and omental adipocytes.2012 Add to clipboard 58: Aberrant activation of the mTOR pathway and anti-tumour effect of everolimus on oesophageal squamous cell carcinoma.2012 Add to clipboard 59: HER2+ Breast Cancer Therapy: By CPP-ZFN Mediated Targeting of mTOR ?2012 Add to clipboard 60: Inhibition of chemokine (C-X-C motif) ligand 12/chemokine (C-X-C motif) receptor 4 axis (CXCL12/CXCR4)-mediated cell migration by targeting mammalian target of rapamycin (mTOR ) pathway in human gastric carcinoma cells.2012 Add to clipboard 61: Akt Inhibitors MK-2206 and Nelfinavir overcome mTOR inhibitor resistance in DLBCL.2012 Add to clipboard 62: Dose-Dependent Effects of Sirolimus on mTOR Signaling and Polycystic Kidney Disease.2012 Add to clipboard 63: Effectiveness of a combination therapy using calcineurin inhibitor and mTOR inhibitor in preventing allograft rejection and post-transplantation renal cancer progression.2012 Add to clipboard 64: Critical role of arachidonic acid-activated mTOR signaling in breast carcinogenesis and angiogenesis.2012 Add to clipboard 65: Modulation of mTOR effector phosphoproteins in blood basophils from allergic patients.2012 Add to clipboard 66: PI3K and mTOR signaling pathways in cancer: new data on targeted therapies.2012 Add to clipboard 67: Inhibition of Na/K-ATPase promotes myocardial tumor necrosis factor-alpha protein expression and cardiac dysfunction via calcium /mTOR signaling in endotoxemia.2012 Add to clipboard 68: Role of PRAS40 in Akt and mTOR signaling in health and disease.2012 Add to clipboard 69: Intestinal cell kinase (ICK) promotes activation of mTOR complex 1 (mTOR C1) through phosphorylation of Raptor Thr-908.2012 Add to clipboard 70: Phase I safety, pharmacokinetic, and pharmacodynamic study of the oral phosphatidylinositol-3-kinase and mTOR inhibitor BGT226 in patients with advanced solid tumors.2012 Add to clipboard 71: The translational landscape of mTOR signalling steers cancer initiation and metastasis.2012 Add to clipboard 72: Synergistic Effects of Erlotinib and Everolimus on Bronchial Carcinoids and Large-Cell Neuroendocrine Carcinomas with Activated EGFR/AKT /mTOR Pathway.2012 Add to clipboard 73: Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy.2012 Add to clipboard 74: Evaluation of Akt /mTOR activity in muscle atrophy after rotator cuff tears in a rat model.2012 Add to clipboard 75: Biologic rationale and clinical activity of mTOR inhibitors in gynecological cancer.2012 Add to clipboard 76: Cross talk between estradiol and mTOR kinase in the regulation of ovarian granulosa proliferation.2012 Add to clipboard 77: CMV late phase-induced mTOR activation is essential for efficient virus replication in polarized human macrophages.2012 Add to clipboard 78: Non-small cell lung carcinoma therapy using mTOR -siRNA.2012 Add to clipboard 79: Antitumor activities of ATP-competitive inhibitors of mTOR in colon cancer cells.2012 Add to clipboard 80: Aspirin Inhibits mTOR Signaling, Activates AMP-Activated Protein Kinase, and Induces Autophagy in Colorectal Cancer Cells.2012 Add to clipboard 81: mTOR is required for asymmetric division through small GTPases in mouse oocytes.2012 Add to clipboard 82: The mTOR Signalling Pathway in Human Cancer.2012 Add to clipboard 83: mTOR as a Molecular Target in HPV-Associated Oral and Cervical Squamous Carcinomas.2012 Add to clipboard 84: mTOR kinase inhibitors as a treatment strategy in hematological malignancies.2012 Add to clipboard 85: The role of mTOR inhibitors in the inhibition of growth and cortisol secretion in human adrenocortical carcinoma cells.2012 Add to clipboard 86: PIK3CA/PTEN mutations and Akt activation as markers of sensitivity to allosteric mTOR inhibitors.2012 Add to clipboard 87: Regulation of mTOR Complex 2 Signaling in Neurofibromatosis 2-Deficient Target Cell Types.2012 Add to clipboard 88: Prolactin and epidermal growth factor stimulate adipophilin synthesis in HC11 mouse mammary epithelial cells via the PI3-kinase/Akt /mTOR pathway.2012 Add to clipboard 89: Delayed mTOR inhibition with low dose of everolimus reduces TGFbeta expression, attenuates proteinuria and renal damage in the renal mass reduction model.2012 Add to clipboard 90: Inhibition of MTOR disrupts autophagic flux in podocytes.2012 Add to clipboard 91: Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling.2012 Add to clipboard 92: PI3-kinase and mTOR inhibitors differently modulate the function of the ABCG2 multidrug transporter.2012 Add to clipboard 93: InTERTesting association between telomerase, mTOR and phytochemicals.2012 Add to clipboard 94: A dynamic network model of mTOR signaling reveals TSC-independent mTOR C2 regulation.2012 Add to clipboard 95: Comparative efficacy of vascular endothelial growth factor (VEGF) tyrosine kinase inhibitor (TKI) and mammalian target of rapamycin (mTOR ) inhibitor as second-line therapy in patients with metastatic renal cell carcinoma after the failure of first-line VEGF TKI.2012 Add to clipboard 96: Major involvement of mTOR in the PPARgamma-induced stimulation of adipose tissue lipid uptake and fat accretion.2012 Add to clipboard 97: Rapamycin ameliorates kidney fibrosis by inhibiting the activation of mTOR signaling in interstitial macrophages and myofibroblasts.2012 Add to clipboard 98: Shear stress induces cell apoptosis via a c-Src-phospholipase D -mTOR signaling pathway in cultured podocytes.2012 Add to clipboard 99: Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia.2012 Add to clipboard 100: Targeting mTOR Pathways in Human Malignancies.2012 Add to clipboard 101: Pneumonitis associated with mTOR inhibitors therapy in patients with metastatic renal cell carcinoma: Incidence, radiographic findings and correlation with clinical outcome.2012 Add to clipboard 102: Regulation of the glutamate transporter EAAT3 by mammalian target of rapamycin mTOR .2012 Add to clipboard 103: The role and regulation of mTOR in T-lymphocyte function.2012 Add to clipboard 104: A Role of the Mammalian Target of Rapamycin (mTOR ) in Glutamate-Induced Down-regulation of Tuberous Sclerosis Complex Proteins 2 (TSC2).2012 Add to clipboard 105: Osmotic Stress Regulates Mammalian Target of Rapamycin (mTOR ) Complex 1 via c-Jun N-terminal Kinase (JNK)-mediated Raptor Protein Phosphorylation.2012 Add to clipboard 106: An overview of the mTOR pathway as a target in cancer therapy.2012 Add to clipboard 107: mTOR -dependent modulation of gastric nesfatin-1/NUCB2.2012 Add to clipboard 108: Cooperative action of JNK and AKT /mTOR in 1-methyl-4-phenylpyridinium-induced autophagy of neuronal PC12 cells.2012 Add to clipboard 109: Regulation and function of mTOR signalling in T cell fate decisions.2012 Add to clipboard 110: mTOR signaling pathway and mTOR inhibitors in cancer therapy.2012 Add to clipboard 111: The Clinical and Prognostic Significance of Activated AKT -mTOR Pathway in Human Astrocytomas.2012 Add to clipboard 112: Aloe-emodin suppresses prostate cancer by targeting the mTOR complex 2.2012 Add to clipboard 113: Regulation of the mTOR signaling network in hibernating thirteen-lined ground squirrels.2012 Add to clipboard 114: mTOR Inhibitors Synergize on Regression, Reversal of Gene Expression, and Autophagy in Hepatocellular Carcinoma.2012 Add to clipboard 115: Mammalian Target of Rapamycin (mTOR ) Inhibition: Potential for Antiseizure, Antiepileptogenic, and Epileptostatic Therapy.2012 Add to clipboard 116: Ubiquitin Specific Peptidase 9, X-linked (USP9X) Modulates the Activity of Mammalian Target of Rapamycin (mTOR ).2012 Add to clipboard 117: Inflammation-Driven Reprogramming of CD4(+)Foxp3(+) Regulatory T Cells into Pathogenic Th1/Th17 T Effectors Is Abrogated by mTOR Inhibition in vivo.2012 Add to clipboard 118: N-acetylcysteine reduces disease activity by blocking mTOR in T cells of lupus patients.2012 Add to clipboard 119: mTOR Pathway Overactivation in BRAF Mutated Papillary Thyroid Carcinoma.2012 Add to clipboard 120: Simultaneous targeting of EGFR and mTOR inhibits the growth of colorectal carcinoma cells.2012 Add to clipboard 121: mTOR inhibitors in the management of hormone receptor-positive breast cancer: the latest evidence and future directions.2012 Add to clipboard 122: The PP242 Mammalian Target of Rapamycin (mTOR ) Inhibitor Activates Extracellular Signal-regulated Kinase (ERK) in Multiple Myeloma Cells via a Target of Rapamycin Complex 1 (TORC1)/ Eukaryotic Translation Initiation Factor 4E (eIF-4E)/RAF Pathway and Activation Is a Mechanism of Resistance.2012 Add to clipboard 123: The dual PI3K and mTOR inhibitor NVP-BEZ235 exhibits anti-proliferative activity and overcomes bortezomib resistance in mantle cell lymphoma cells.2012 Add to clipboard 124: Cardiac mTOR protects the heart against ischemia-reperfusion injury.2012 Add to clipboard 125: Clinicopathological correlations of mTOR and pAkt expression in non-small cell lung cancer.2012 Add to clipboard 126: Suppression of proinvasive RGS4 by mTOR inhibition optimizes glioma treatment.2012 Add to clipboard 127: The interaction between early life epilepsy and autistic-like behavioral consequences: a role for the mammalian target of rapamycin (mTOR ) pathway.2012 Add to clipboard 128: AKT /mTOR as Novel Targets of Polyphenol Piceatannol Possibly Contributing to Inhibition of Proliferation of Cultured Prostate Cancer Cells.2012 Add to clipboard 129: Targeting mTOR as a novel therapeutic strategy for traumatic CNS injuries.2012 Add to clipboard 130: Finding a better drug for epilepsy: The mTOR pathway as an antiepileptogenic target.2012 Add to clipboard 131: Reduction of insulin signalling pathway IRS-1/IRS-2/AKT /mTOR and decrease of epithelial cell proliferation in the prostate of glucocorticoid-treated rats.2012 Add to clipboard 132: The mTOR Pathway in Lung Cancer and Implications for Therapy and Biomarker Analysis.2012 Add to clipboard 133: Metformin and the mTOR Inhibitor Everolimus (RAD001) Sensitize Breast Cancer Cells to the Cytotoxic Effect of Chemotherapeutic Drugs In Vitro.2012 Add to clipboard 134: Tumor necrosis factor-alpha (TNF-alpha)-mediated in vitro human retinal pigment epithelial (RPE) cell migration mainly requires Akt /mTOR complex 1 (mTOR C1), but not mTOR complex 2 (mTOR C2) signaling.2012 Add to clipboard 135: Neuregulin Promotes Incomplete Autophagy of Prostate Cancer Cells That Is Independent of mTOR Pathway Inhibition.2012 Add to clipboard 136: The mTOR pathway is activated in glial cells in mesial temporal sclerosis.2012 Add to clipboard 137: Plasticity and mTOR : Towards Restoration of Impaired Synaptic Plasticity in mTOR -Related Neurogenetic Disorders.2012 Add to clipboard 138: Evidence of Ambiguous Differentiation and mTOR Pathway Dysregulation in Subependymal Giant Cell Astrocytoma.2012 Add to clipboard 139: Leucine stimulates insulin secretion via down-regulation of surface expression of adrenergic alpha 2A receptor through the mTOR pathway and its implication in new-onset diabetes in renal transplantation.2012 Add to clipboard 140: Development of PI3K/AKT /mTOR Pathway Inhibitors and Their Application in Personalized Therapy for Non-Small-Cell Lung Cancer.2012 Add to clipboard 141: Leucine induces myofibrillar protein accretion in cultured skeletal muscle through mTOR dependent and -independent control of myosin heavy chain mRNA levels.2012 Add to clipboard 142: Alterations of the p53 and PIK3CA/AKT /mTOR pathways in angiosarcomas: A pattern distinct from other sarcomas with complex genomics.2012 Add to clipboard 143: Akt (protein kinase B) isoform phosphorylation and signaling downstream of mTOR (mammalian target of rapamycin ) in denervated atrophic and hypertrophic mouse skeletal muscle.2012 Add to clipboard 144: Genotype-Dependent Efficacy of a Dual PI3K /mTOR Inhibitor, NVP-BEZ235, and an mTOR Inhibitor, RAD001, in Endometrial Carcinomas.2012 Add to clipboard 145: Silencing of Twist1 sensitizes NSCLC cells to cisplatin via AMPK-activated mTOR inhibition.2012 Add to clipboard 146: Hepatitis C virus upregulates Beclin1 for induction of autophagy and activates mTOR signaling.2012 Add to clipboard 147: Homeostasis and the Importance for a Balance Between AKT /mTOR Activity and Intracellular Signaling.2012 Add to clipboard 148: Rapamycin Inhibits the mTOR /p70S6K Pathway and Attenuates Cardiac Fibrosis in Adriamycin-induced Dilated Cardiomyopathy.2012 Add to clipboard 149: Suppression of EphB4 improves the inhibitory effect of mTOR shRNA on the biological behaviors of ovarian cancer cells by down-regulating Akt phosphorylation.2012 Add to clipboard 150: Aberrant STAT5 and PI3K /mTOR pathway signaling occurs in human CRLF2-rearranged B-precursor acute lymphoblastic leukemia.2012 Add to clipboard 151: Incidence and management of mTOR inhibitor-associated pneumonitis in patients with metastatic renal cell carcinoma.2012 Add to clipboard 152: The mTOR -inhibitor Rapamycin mediates proteinuria in nephrotoxic serum nephritis by activating the innate immune response.2012 Add to clipboard 153: Nuclear factor of activated T-cells (NFAT) c3 inhibition of mTOR signaling through induction of REDD1 in human intestinal cells.2012 Add to clipboard 154: Caveolin-1 and Accelerated Host Aging in the Breast Tumor Microenvironment: Chemoprevention with Rapamycin , an mTOR Inhibitor and Anti-Aging Drug.2012 Add to clipboard 155: Efficacy of everolimus, a novel mTOR inhibitor, against basal-like triple-negative breast cancer cells.2012 Add to clipboard 156: Atorvastatin enhances neurite outgrowth in cortical neurons in vitro via up-regulating the Akt /mTOR and Akt/GSK-3beta signaling pathways.2012 Add to clipboard 157: Decreased lactate concentration and glycolytic enzyme expression reflect inhibition of mTOR signal transduction pathway in B-cell lymphoma.2012 Add to clipboard 158: Activated mTOR /P70S6K signaling pathway is involved in insulinoma tumorigenesis.2012 Add to clipboard 159: Lymphedema of the Breast as a Symptom of Internal Diseases or Side Effect of mTor Inhibitors.2012 Add to clipboard 160: Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells.2012 Add to clipboard 161: L-Leucine improves anemia and developmental defects associated with Diamond-Blackfan anemia and del(5q)MDS by activating the mTOR pathway.2012 Add to clipboard 162: Guanosine produces an antidepressant-like effect through the modulation of NMDA receptors, nitric oxide-cGMP and PI3K /mTOR pathways.2012 Add to clipboard 163: Targeting the mTOR -DEPTOR Pathway by CRL E3 Ubiquitin Ligases: Therapeutic Application.2012 Add to clipboard 164: Chronic inhibition of mTOR by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice.2012 Add to clipboard 165: .2012 Add to clipboard 166: Mapping the Spatio-Temporal Pattern of the Mammalian Target of Rapamycin (mTOR ) Activation in Temporal Lobe Epilepsy.2012 Add to clipboard 167: mTOR Is Essential for the Proteotoxic Stress Response, HSF1 Activation and Heat Shock Protein Synthesis.2012 Add to clipboard 168: Identification of Akt-Independent Regulation of Hepatic Lipogenesis by Mammalian Target of Rapamycin (mTOR ) Complex 2.2012 Add to clipboard 169: Glucocorticoids Modulate the mTOR Pathway in the Hippocampus: Differential Effects Depending on Stress History.2012 Add to clipboard 170: Management of Metabolic Effects Associated With Anticancer Agents Targeting the PI3K-Akt -mTOR Pathway.2012 Add to clipboard 171: Resistance to the mTOR -inhibitor RAD001 elevates integrin alpha2- and beta1-triggered motility, migration and invasion of prostate cancer cells.2012 Add to clipboard 172: Response to Comment on"A Dynamic Network Model of mTOR Signaling Reveals TSC-Independent mTOR C2 Regulation": Building a Model of the mTOR Signaling Network with a Potentially Faulty Tool.2012 Add to clipboard 173: Immunohistochemical Analysis of the Akt /mTOR /4E-BP1 Signalling Pathway in Canine Haemangiomas and Haemangiosarcomas.2012 Add to clipboard 174: Altered LKB1/AMPK/TSC1/TSC2 /mTOR signaling causes disruption of Sertoli cell polarity and spermatogenesis.2012 Add to clipboard 175: Identification of mammalian target of rapamycin (mTOR ) as a direct target of fenretinib both in vitro and in vivo.2012 Add to clipboard 176: Impact of Combined mTOR and MEK Inhibition in Uveal Melanoma Is Driven by Tumor Genotype.2012 Add to clipboard 177: Advancing age is associated with gene expression changes resembling mTOR inhibition: Evidence from two human populations.2012 Add to clipboard 178: Glutamate transporter-dependent mTOR phosphorylation in Muller glia cells.2012 Add to clipboard 179: Dual targeting of mTOR and Aurora-A kinase for the treatment of uterine leiomyosarcoma.2012 Add to clipboard 180: The mTOR Signaling Pathway in the Brain: Focus on Epilepsy and Epileptogenesis.2012 Add to clipboard 181: Targeting of mTOR C1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML under conditions mimicking the bone marrow microenvironment.2012 Add to clipboard 182: Constitutive activation of the mTOR signaling pathway within the normal glomerulus.2012 Add to clipboard 183: EGFR and HER2-Akt -mTOR signaling pathways are activated in subgroups of salivary gland carcinomas.2012 Add to clipboard 184: Disrupting the mTOR signaling network as a potential strategy for the enhancement of cancer radiotherapy.2012 Add to clipboard 185: Perspectives on mTOR Inhibitors for Castration-Refractory Prostate Cancer.2012 Add to clipboard 186: Synthesis and structure-activity relationships of dual PI3K /mTOR inhibitors based on a 4-amino-6-methyl-1,3,5-triazine sulfonamide scaffold.2012 Add to clipboard 187: IL-22 induced cell proliferation is regulated by PI3K/Akt /mTOR signaling cascade.2012 Add to clipboard 188: PI3K /mTOR Signaling Pathways in Medulloblastoma.2012 Add to clipboard 189: Targeting the PI3K/AKT /mTOR Signaling Axis in Children with Hematologic Malignancies.2012 Add to clipboard 190: N-Carbamylglutamate Enhances Pregnancy Outcome in Rats through Activation of the PI3K/PKB /mTOR Signaling Pathway.2012 Add to clipboard 191: Hepatitis B Virus X Protein Upregulates mTOR Signaling through IKKbeta to Increase Cell Proliferation and VEGF Production in Hepatocellular Carcinoma.2012 Add to clipboard 192: Chemopreventive and chemotherapeutic actions of mTOR inhibitor in genetically-defined head and neck squamous cell carcinoma mouse model.2012 Add to clipboard 193: Pharmacological targeting of mammalian target of rapamycin (mTOR ) inhibits ovarian granulosa cell tumor growth.2012 Add to clipboard 194: New Inhibitors of the PI3K-Akt -mTOR Pathway: Insights into mTOR Signaling from a New Generation of Tor Kinase Domain Inhibitors (TORKinibs).2011 Add to clipboard 195: The PI3K/Akt /mTOR pathway is activated in murine lupus nephritis and downregulated by rapamycin .2011 Add to clipboard 196: Activation of mTOR and RhoA is a major http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/show_sentences.cgi
标签: 下丘脑
