最近有幸参观美国农业部盐土实验室（Salinity Laboratory, Agricultural Research Service, United States Department of Agriculture）。 盐土实验室是 美国农业部下属、 以盐土为研究对象的实验室，它是国际 土壤物理学研究领域一个比较出名的实验室。土壤物理学界多个牛人均栖身于该实验室，其中有做土壤水分特征曲线出名的 van Genuchten等，不过近些年退休、跳槽了很多。个人感觉， 目前实验室总体上比较萧条，岗位空缺较多，很多实验仪器装置均闲置，估计一方面跟美国的经济大环境有关，另一方面跟目前土壤学或土壤物理学的学科整体衰败有关。
content: 1 development of the experiment on hand. 2discuss the protocol which is to perform. 3 report the references you have read,include methods, ideas, investigation index, etc. what enlightened you.
LABORATORY INVESTIGATION September 2010 Volume 90 Number 9, pp 1272 - 1402 --------------------------------------------------------------------- Start your summer reading with open access to six articles from Laboratory Investigation and Modern Pathology. These hot articles present key findings in clinical and experimental cancer pathology. http://links.ealert.nature.com/ctt?kn=44m=35749727r=Mzg0ODUxNzc1MwS2b=2j=ODA4MjIwNjES1mt=1rt=0 ---------------------- INSIDE LI ---------------------- Inside Lab Invest http://links.ealert.nature.com/ctt?kn=14m=35749727r=Mzg0ODUxNzc1MwS2b=2j=ODA4MjIwNjES1mt=1rt=0 ---------------------- PATHOBIOLOGY IN FOCUS ---------------------- Role of serum response factor in the pathogenesis of disease Joseph M Miano Abstract: http://links.ealert.nature.com/ctt?kn=15m=35749727r=Mzg0ODUxNzc1MwS2b=2j=ODA4MjIwNjES1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=16m=35749727r=Mzg0ODUxNzc1MwS2b=2j=ODA4MjIwNjES1mt=1rt=0 ---------------------- RESEARCH ARTICLES ---------------------- ORAL AND GASTROINTESTINAL SYSTEMS A molecular portrait of gastrointestinal stromal tumors: an integrative analysis of gene expression profiling and high-resolution genomic copy number Annalisa Astolfi, Margherita Nannini, Maria Abbondanza Pantaleo, Monica Di Battista, Michael C Heinrich, Donatella Santini, Fausto Catena, Christopher L Corless, Alessandra Maleddu, Maristella Saponara, Cristian Lolli, Valerio Di Scioscio, Serena Formica and Guido Biasco Abstract: http://links.ealert.nature.com/ctt?kn=85m=35749727r=Mzg0ODUxNzc1MwS2b=2j=ODA4MjIwNjES1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=83m=35749727r=Mzg0ODUxNzc1MwS2b=2j=ODA4MjIwNjES1mt=1rt=0 Toll-like receptor 4 differentially regulates epidermal growth factor-related growth factors in response to intestinal mucosal injury David Hsu, Masayuki Fukata, Yasmin G Hernandez, John P Sotolongo, Tyralee Goo, Junsuke Maki, Lory A Hayes, Ryan C Ungaro, Anli Chen, Keith J Breglio, Ruliang Xu and Maria T Abreu Abstract: http://links.ealert.nature.com/ctt?kn=84m=35749727r=Mzg0ODUxNzc1MwS2b=2j=ODA4MjIwNjES1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=80m=35749727r=Mzg0ODUxNzc1MwS2b=2j=ODA4MjIwNjES1mt=1rt=0 HEPATIC AND PANCREATIC SYSTEMS Cellular and molecular mechanisms regulating the hepatic erythropoietin expression during acute-phase response: a role for IL-6 Pierluigi Ramadori, Ghayyor Ahmad and Giuliano Ramadori Abstract: http://links.ealert.nature.com/ctt?kn=82m=35749727r=Mzg0ODUxNzc1MwS2b=2j=ODA4MjIwNjES1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=78m=35749727r=Mzg0ODUxNzc1MwS2b=2j=ODA4MjIwNjES1mt=1rt=0 Resveratrol enhances the sensitivity of cholangiocarcinoma to chemotherapeutic agents Gabriel A Frampton, Eric A Lazcano, Huang Li, Akimuddin Mohamad and Sharon DeMorrow Abstract: http://links.ealert.nature.com/ctt?kn=79m=35749727r=Mzg0ODUxNzc1MwS2b=2j=ODA4MjIwNjES1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=90m=35749727r=Mzg0ODUxNzc1MwS2b=2j=ODA4MjIwNjES1mt=1rt=0 Reduced transforming growth factor- receptor II expression in hepatocellular carcinoma correlates with intrahepatic metastasis Takao Mamiya, Ken Yamazaki, Yohei Masugi, Taisuke Mori, Kathryn Effendi, Wenlin Du, Taizo Hibi, Minoru Tanabe, Masakazu Ueda, Tadatoshi Takayama and Michiie Sakamoto Abstract: http://links.ealert.nature.com/ctt?kn=91m=35749727r=Mzg0ODUxNzc1MwS2b=2j=ODA4MjIwNjES1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=88m=35749727r=Mzg0ODUxNzc1MwS2b=2j=ODA4MjIwNjES1mt=1rt=0 BLOOD, LYMPHATICS, IMMUNE SYSTEM, STEM CELLS Inhibition of c-MET is a potential therapeutic strategy for treatment of diffuse large B-cell lymphoma Shahab Uddin, Azhar R Hussain, Maqbool Ahmed, Fouad Al-Dayel, Rong Bu, Prashant Bavi and Khawla S Al-Kuraya Abstract: http://links.ealert.nature.com/ctt?kn=59m=35749727r=Mzg0ODUxNzc1MwS2b=2j=ODA4MjIwNjES1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=61m=35749727r=Mzg0ODUxNzc1MwS2b=2j=ODA4MjIwNjES1mt=1rt=0 Mice lacking Dok-1, Dok-2, and Dok-3 succumb to aggressive histiocytic sarcoma Ryuichi Mashima, Kazuho Honda, Yi Yang, Yohei Morita, Akane Inoue, Sumimasa Arimura, Hiroshi Nishina, Hideo Ema, Hiromitsu Nakauchi, Brian Seed, Hideaki Oda and Yuji Yamanashi Abstract: http://links.ealert.nature.com/ctt?kn=63m=35749727r=Mzg0ODUxNzc1MwS2b=2j=ODA4MjIwNjES1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=65m=35749727r=Mzg0ODUxNzc1MwS2b=2j=ODA4MjIwNjES1mt=1rt=0 ENDOCRINE, VISUAL AND AUDITORY SYSTEMS Matrix metalloproteinase-2 in the development of diabetic retinopathy and mitochondrial dysfunction Ghulam Mohammad and Renu A Kowluru Abstract: http://links.ealert.nature.com/ctt?kn=50m=35749727r=Mzg0ODUxNzc1MwS2b=2j=ODA4MjIwNjES1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=53m=35749727r=Mzg0ODUxNzc1MwS2b=2j=ODA4MjIwNjES1mt=1rt=0 c-Kit and stem cell factor regulate PANC-1 cell differentiation into insulin- and glucagon-producing cells Yuexiu Wu, Jinming Li, Saira Saleem, Siu-Pok Yee, Anandwardhan A Hardikar and Rennian Wang Abstract: http://links.ealert.nature.com/ctt?kn=57m=35749727r=Mzg0ODUxNzc1MwS2b=2j=ODA4MjIwNjES1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=58m=35749727r=Mzg0ODUxNzc1MwS2b=2j=ODA4MjIwNjES1mt=1rt=0 BREAST, SKIN, SOFT TISSUE AND BONE Selective deletion of adipocytes, but not preadipocytes, by TNF- through C/EBP- and PPAR -mediated suppression of NF- B Minori Tamai, Tsuyoshi Shimada, Nobuhiko Hiramatsu, Kunihiro Hayakawa, Maro Okamura, Yasuhiro Tagawa, Shuhei Takahashi, Shotaro Nakajima, Jian Yao and Masanori Kitamura Abstract: http://links.ealert.nature.com/ctt?kn=70m=35749727r=Mzg0ODUxNzc1MwS2b=2j=ODA4MjIwNjES1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=71m=35749727r=Mzg0ODUxNzc1MwS2b=2j=ODA4MjIwNjES1mt=1rt=0 Accurate quantification of dystrophin mRNA and exon skipping levels in Duchenne Muscular Dystrophy Pietro Spitali, Hans Heemskerk, Rolf HAM Vossen, Alessandra Ferlini, Johan T den Dunnen, Peter AC 't Hoen and Annemieke Aartsma-Rus Abstract: http://links.ealert.nature.com/ctt?kn=35m=35749727r=Mzg0ODUxNzc1MwS2b=2j=ODA4MjIwNjES1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=17m=35749727r=Mzg0ODUxNzc1MwS2b=2j=ODA4MjIwNjES1mt=1rt=0 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TABLE OF CONTENTS Volume 90, Issue 1 (January 2010) In this issue Inside LI Editorials Research Articles Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement Laboratory Investigation - dedication to the publication of current research that significantly advances the understanding of human and experimental disease. Particular emphasis is given to original research exploring the pathobiology of disease, including insights gained into the structural and molecular pathogenesis of disease, and the biological basis for morphologic manifestations of disease. Visit the journal online to learn more www.laboratoryinvestigation.org Will your paper be seen by more than 40,000 online users this month? It will with LI . Authors receive a fast turnaround from submission to publication. Why submit to LI ? - Impact factor of 4.580* - Ranked in the top ten of pathology journals - Three FREE pages of color for authors - Attracts more than 11,000 new site visitors per month Read the Full Guide to Authors for more information. *2008 Journal Citation Report (Thomson Reuters 2009) Inside LI Top Inside Lab Invest 2010 90: 2-3; 10.1038/labinvest.2009.134 Abstract | Full Text Editorials Top What editors want in an abstract Catherine MKetcham, Robert WHardy, BrianRubin and Gene PSiegal 2010 90: 4-5; 10.1038/labinvest.2009.122 Abstract | Full Text Attacking the source: anti-PDX-1 responses in type 1 diabetes YaimaLuzardo and Clayton ElwoodMathews 2010 90: 6-8; 10.1038/labinvest.2009.121 Abstract | Full Text Research Articles Top FTY720, a sphingosine 1-phosphate receptor modulator, inhibits CD1d-restricted NKT cells by suppressing cytokine production but not migration Su JinHwang, Ji HyungKim, Hye YoungKim, SangheeKim and Doo HyunChung 2010 90: 9-19; advance online publication, October 12, 2009; 10.1038/labinvest.2009.109 Abstract | Full Text Rho / ROCK and MEK / ERK activation by transforming growth factor- induces articular cartilage degradation C Thomas GAppleton, Shirine EUsmani, John SMort and FrankBeier 2010 90: 20-30; advance online publication, October 12, 2009; 10.1038/labinvest.2009.111 Abstract | Full Text Pancreatic duodenal homeobox 1 protein is a novel -cell-specific autoantigen for type I diabetes Shi-WuLi, VijayKoya, YiLi, WilliamDonelan, PengLin, Westley HReeves and Li-JunYang 2010 90: 31-39; advance online publication, November 9, 2009; 10.1038/labinvest.2009.116 Abstract | Full Text Erythropoietin-induced upregulation of endothelial nitric oxide synthase but not vascular endothelial growth factor prevents musculocutaneous tissue from ischemic damage FaridRezaeian, RetoWettstein, Jean-FranoisEgger, FreyaSandmann, MartinRcker, MickalTobalem, BrigitteVollmar, Michael DMenger and YvesHarder 2010 90: 40-51; advance online publication, November 9, 2009; 10.1038/labinvest.2009.117 Abstract | Full Text Acyclic retinoid inhibits angiogenesis by suppressing the MAPK pathway YusukeKomi, YukihisaSogabe, NaotoIshibashi, YasufumiSato, HisatakaMoriwaki, KentaroShimokado and SoichiKojima 2010 90: 52-60; advance online publication, October 19, 2009; 10.1038/labinvest.2009.110 Abstract | Full Text Isolation of targeting nanobodies against co-opted tumor vasculature IlseRoodink, MaartenFranssen, MalouZuidscherwoude, KiekVerrijp, Tomvan der Donk, JosRaats and William PJLeenders 2010 90: 61-67; advance online publication, October 12, 2009; 10.1038/labinvest.2009.107 Abstract | Full Text Effects of sulfur dioxide on hypoxic pulmonary vascular structural remodeling YanSun, YueTian, MainaliPrabha, DieLiu, StellaChen, RongyuanZhang, XueqinLiu, ChaoshuTang, XiuyingTang, HongfangJin and JunbaoDu 2010 90: 68-82; advance online publication, October 12, 2009; 10.1038/labinvest.2009.102 Abstract | Full Text Nephron-deficient Fvb mice develop rapidly progressive renal failure and heavy albuminuria involving excess glomerular GLUT1 and VEGF YouliWang, Kathleen OHeilig, Andrew WMinto, ShenglinChen, MinghuiXiang, David ADean, Richard CGeiger, AnthonyChang, Dimitrina DPravtcheva, MartinSchlimme, Dilip KDeb, YingWang and Charles WHeilig 2010 90: 83-97; advance online publication, November 16, 2009; 10.1038/labinvest.2009.95 Abstract | Full Text Intrarenal expre ssion of microRNAs in patients with IgA nephropathy GangWang, Bonnie C-HKwan, Fernand M-MLai, Paul C-LChoi, Kai-MingChow, Philip K-TLi and Cheuk-ChunSzeto 2010 90: 98-103; advance online publication, November 9, 2009; 10.1038/labinvest.2009.118 Abstract | Full Text Curcumin limits the fibrogenic evolution of experimental steatohepatitis FrancescoVizzutti, AngelaProvenzano, SaraGalastri, StefanoMilani, WandaDelogu, EricaNovo, AlessandraCaligiuri, ElenaZamara, UmbertoArena, GiacomoLaffi, MaurizioParola, MassimoPinzani and FabioMarra 2010 90: 104-115; advance online publication, November 9, 2009; 10.1038/labinvest.2009.112 Abstract | Full Text Inhibition of nitric oxide synthesis during induced cholestasis ameliorates hepatocellular injury by facilitating S-nitrosothiol homeostasis Laura MLpez-Snchez, Fernando JCorrales, MontserratBarcos, IsabelEspejo, Juan RMuoz-Castaeda and AntonioRodrguez-Ariza 2010 90: 116-127; advance online publication, October 5, 2009; 10.1038/labinvest.2009.104 Abstract | Full Text Plasma concentrations of inflammatory cytokines rise rapidly during ECMO-related SIRS due to the release of preformed stores in the intestine R BrittMcILwain, Joseph GTimpa, Ashish RKurundkar, David WHolt, David RKelly, Yolanda EHartman, Mary LaurenNeel, Rajendra KKarnatak, Robert LSchelonka, G MAnantharamaiah, Cheryl RKillingsworth and AkhilMaheshwari 2010 90: 128-139; advance online publication, November 9, 2009; 10.1038/labinvest.2009.119 Abstract | Full Text
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Good Laboratory Practice Regulations Third Edition, Revised and Expanded Sandy Weinberg ISBN: 0824708911 | Year 2003 | English 264pages | pdf | size:2,83Mb Exploring the role of Good Laboratory Practices (GLP) in the assurance of safety, quality, and control in regulated arenas, this reference details specific standards and general guidelines for the management of efficient and effective research environments-presenting essential theoretical principles for anticipating new and emerging interpretations of GLP in a variety of laboratory settings. The Third Edition of Good Laboratory Practice Regulations contains current material on the utilization and implementation of 21 CFR Part 11 guidelines for LIMS and other computerized laboratory system? the effects of automation of GLP practices??and the application of GLP standards to non-GLP laboratories??and analyzes GLP enforcement??the FDA`s GLP Inspection Program??the ability of GLP to advance along with the ever-changing functions of laboratory operation, supervision, and maintenance??and the impact of GLP on research, production, and clinical testing. Table of Contents: Historical Perspective by Jean M. Taylor and Gary C. Stein FDA/ GLP Regulations by Wendell A. Peterson Applying 21 CFR Part 11 to the Laboratory Environment by Sandy Weinberg The Good Automated Laboratory Practices by Gerald J. Whartenby, Paul L. Robinson, and Sandy Weinberg Implementing GLPs in a Non-GLP Analytical Laboratory by Stephanie A. Olexa Computer Systems Validation by Sandy Weinberg The FDAs GLP Inspection Program by George W. James The Future by Sandy Weinberg Bibliography Index Download: Good Laboratory Practice Regulations,Third Edition
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