哈佛图书馆墙壁训言: 1、此刻打盹,你将做梦;此刻学习,你将圆梦。(This moment will nap, you will have a dream; But this moment study,you will interpret a dream. ) 2、我荒废的今日,正是昨日殒身之人祈求的明日。(I leave uncultivated today, was precisely yesterday perishes tomorrow which person of the body implored.) 3、觉得为时已晚的时候,恰恰是最早的时候。 (Thought is already is late, exactly is the earliest time.) 4、勿将今日之事拖到明日。(Not matter of the today will drag tomorrow. ) 5、学习时的苦痛是暂时的,未学到的痛苦是终生的。 (Time the study pain is temporary, has not learned the pain islife-long. ) 6、学习不是缺乏时间,而是缺乏努力。(Studies this matter, lacks the time, but is lacks diligently.) 7、幸福或许不排名次,但成功必排名次。(Perhaps happiness does not arrange the position, but succeeds must arrange the position. ) 8、学习并不是人生的全部。但既然连人生的一部分也无法征服,还能做什么呢?(The study certainly is not the life complete. But, since continually life part of-studies also is unable to conquer, what butalso can make?) 9、请享受无法回避的痛苦。(Please enjoy the pain which is unable to avoid.) 10、只有比别人更早、更勤奋地努力,才能尝到成功的滋味。(only has compared to the others early, diligently diligently, canfeel the successful taste.) 11、谁也不能随随便便成功,它来自彻底的自我管理和毅力。(Nobody can casually succeed, it comes from the thoroughself-control and the will. )'
中国科学家精确测定朝鲜核试验当量:8000吨 (来源:中科院地质与地球物理研究所) 2013年2月12日 朝鲜 地下核试验的初步调查结果 作者:赵连锋1 谢小碧2 王卫民3 姚振兴1 1、中国科学院地质与地球物理研究所,北京,100029 2、美国加州大学圣克鲁兹分校地球物理与天体物理研究所,圣克鲁兹,CA95064 3、中国科学院青藏高原研究所,北京,100085 据外电报道,朝鲜于2013年2月12日在(41.302°N, 129.066°E)进行了第三次也是迄今为止最大的一次地下核爆试验。与朝鲜接壤地区的中国居民对该事件有震感。 美国地质调查局(USGS)给出此次事件的震级为M 5.1,中国地震信息网公布的面波震级为Ms 4.9。我们根据中国国家数字地震台网资料,测定了该事件的 体波 震级mb(Lg)为4.93±0.21,估计了该事件的当量约为8千吨。 作为比较,下表一并列出了此次朝鲜核试验与之前于2006年10月9日和2009年5月25日两次地下核试验的参数。 事件 体波震级mb(Lg) 当量(kt) 参考文献 2006-10-09 3.93 0.48 Zhao et al., 2008 2009-05-25 4.53 2.35 Zhao et al., 2012 2013-02-12 4.93 8.08 本研究 图1为三次朝鲜核爆在牡丹江地震台(MDJ)的垂直分量 波形记录 。三次事件的波形极为相似,均具有显著的爆炸震源特征。P波具有尖锐的初至且能量较大。由于震源深度小,周期为3-5 s的Rayleigh面波发育良好。 图1三次朝鲜核爆在牡丹江地震台(MDJ)垂直分量波形记录 图2为朝鲜核爆在MDJ、SNY和BNX地震台得到的垂直分量振幅谱,其中P波能量高于Lg波的能量。由于此次核爆震级较大,因此具有较高的信噪比。 图2 朝鲜 核爆在MDJ、SNY和BNX地震台所记录到的垂直分量记录的频谱 图3是由区域地震台网得到的平均谱比值Pg/Lg,其中红色为核爆炸源的结果,黑色为天然地震事件的结果。结果表明,采用谱比值方法可以有效地识别爆炸震源和天然地震。该结果也证明,此次发生在中朝边界地区的事件确为一次地下核试验。 图3 区域地震台网平均的谱比值Pg/Lg,能够有效地区分爆炸源(红色)和天然地震事件(黑色) 利用我们得到的此次事件的 体波 震级mb(Lg)与Bowers et al.(2001)的震级与爆炸当量的经验关系可以估计朝鲜核爆的当量,其过程如图4所示。 图4 朝鲜 核爆的当量估计 参考文献: Zhao, L. F., X. B. Xie, W. M. Wang, and Z. X. Yao. 2008. Regional seismic characteristics of the October 9, 2006 North Korean nuclear test. Bull. Seism. Soc. Am., 98: 2571-2589, doi: 10.1785/0120080128. Zhao, L. F., X. B. Xie, W. M. Wang, and Z. X. Yao. 2012. Yield estimation of the 25 May 2009 North Korean nuclear explosion. Bull Seism. Soc. Am., 102: 467-478, doi: 10.1785/0120110163. Bowers, D., P. D. Marshall, and A. Douglas. 2001. The level of deterrence provided by data from the SPITS seismometer array to possible violations of the comprehensive test ban in the Novaya Zemlya region. Geophys. J. Int., 146: 425-438, doi 10.1046/j.1365- 246x.2001.01462.x. Nuttli, O. W. 1986. Lg magnitudes of selected East Kazakhstan underground explosions. Bull. Seismol. Soc. Am., 76: 1241-1251. Ringdal, F., P. D. Marshall, and R. W. Alewine. 1992. Seismic yield determination of Soviet underground explosions at the Shagan River test site. Geophys. J. Int., 109: 65-77, doi 10.1111/j.1365- 246X.1992.tb00079.x. Murphy, J. R. 1996. Type of seismic events and their source descriptions. In Monitoring a Comprehensive Test Ban Treaty, E. S. Husebye and A. M. Dainty (Editors), Kluwer Academic Publishers, Dordrecht, 225
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Global warming stopped 16 years ago, reveals Met Office report quietly released... and here is the chart to prove it The figures reveal that from the beginning of 1997 until August 2012 there was no discernible rise in aggregate global temperatures This means that the ‘pause’ in global warming has now lasted for about the same time as the previous period when temperatures rose, 1980 to 1996 By David Rose PUBLISHED: 21:42 GMT, 13 October 2012 | UPDATED: 13:59 GMT, 16 October 2012 Comments ( 957 ) Share The world stopped getting warmer almost 16 years ago, according to new data released last week. The figures, which have triggered debate among climate scientists, reveal that from the beginning of 1997 until August 2012, there was no discernible rise in aggregate global temperatures. This means that the ‘plateau’ or ‘pause’ in global warming has now lasted for about the same time as the previous period when temperatures rose, 1980 to 1996. Before that, temperatures had been stable or declining for about 40 years. global temperature changes Research: The new figures mean that the 'pause' in global warming has now lasted for about the same time as the previous period when temperatures rose, 1980 to 1996. This picture shows an iceberg melting in Eastern Greenland The new data, compiled from more than 3,000 measuring points on land and sea, was issued quietly on the internet, without any media fanfare, and, until today, it has not been reported. This stands in sharp contrast to the release of the previous figures six months ago, which went only to the end of 2010 – a very warm year. Ending the data then means it is possible to show a slight warming trend since 1997, but 2011 and the first eight months of 2012 were much cooler, and thus this trend is erased. More... Wettest start to autumn for 12 years as South West continues to be battered by torrential rain Some climate scientists, such as Professor Phil Jones, director of the Climatic Research Unit at the University of East Anglia, last week dismissed the significance of the plateau, saying that 15 or 16 years is too short a period from which to draw conclusions. Others disagreed. Professor Judith Curry, who is the head of the climate science department at America’s prestigious Georgia Tech university, told The Mail on Sunday that it was clear that the computer models used to predict future warming were ‘deeply flawed’. Even Prof Jones admitted that he and his colleagues did not understand the impact of ‘natural variability’ – factors such as long-term ocean temperature cycles and changes in the output of the sun. However, he said he was still convinced that the current decade would end up significantly warmer than the previous two. Disagreement: Professor Phil Jones, left, from the University of East Anglia, dismissed the significance of the plateau. Professor Judith Curry, right, from Georgia Tech university in America, disagreed, saying the computer models used to predict future warming were ‘deeply flawed’ Warmer: Since 1880 the world has warmed by 0.75 degrees Celsius. This image shows floating icebergs in Greenland The regular data collected on global temperature is called Hadcrut 4, as it is jointly issued by the Met Office’s Hadley Centre and Prof Jones’s Climatic Research Unit. Since 1880, when worldwide industrialisation began to gather pace and reliable statistics were first collected on a global scale, the world has warmed by 0.75 degrees Celsius. Some scientists have claimed that this rate of warming is set to increase hugely without drastic cuts to carbon-dioxide emissions, predicting a catastrophic increase of up to a further five degrees Celsius by the end of the century. The new figures were released as the Government made clear that it would ‘bend’ its own carbon-dioxide rules and build new power stations to try to combat the threat of blackouts. At last week’s Conservative Party Conference, the new Energy Minister, John Hayes, promised that ‘the high-flown theories of bourgeois Left-wing academics will not override the interests of ordinary people who need fuel for heat, light and transport – energy policies, you might say, for the many, not the few’ – a pledge that has triggered fury from green activists, who fear reductions in the huge subsidies given to wind-turbine firms. Flawed science costs us dearly Here are three not-so trivial questions you probably won’t find in your next pub quiz. First, how much warmer has the world become since a) 1880 and b) the beginning of 1997? And what has this got to do with your ever-increasing energy bill? You may find the answers to the first two surprising. Since 1880, when reliable temperature records began to be kept across most of the globe, the world has warmed by about 0.75 degrees Celsius. From the start of 1997 until August 2012, however, figures released last week show the answer is zero: the trend, derived from the aggregate data collected from more than 3,000 worldwide measuring points, has been flat. Surprising: News that the world has got no warmer for the past 16 years will come as something of a shock. This picture shows drifting ice in Canada Not that there has been any coverage in the media, which usually reports climate issues assiduously, since the figures were quietly release online with no accompanying press release – unlike six months ago when they showed a slight warming trend. The answer to the third question is perhaps the most familiar. Your bills are going up, at least in part, because of the array of ‘green’ subsidies being provided to the renewable energy industry, chiefly wind. They will cost the average household about 100 this year. This is set to rise steadily higher – yet it is being imposed for only one reason: the widespread conviction, which is shared by politicians of all stripes and drilled into children at primary schools, that, without drastic action to reduce carbon-dioxide emissions, global warming is certain soon to accelerate, with truly catastrophic consequences by the end of the century – when temperatures could be up to five degrees higher. Hence the significance of those first two answers. Global industrialisation over the past 130 years has made relatively little difference. And with the country committed by Act of Parliament to reducing CO2 by 80 per cent by 2050, a project that will cost hundreds of billions, the news that the world has got no warmer for the past 16 years comes as something of a shock. It poses a fundamental challenge to the assumptions underlying every aspect of energy and climate change policy. This ‘plateau’ in rising temperatures does not mean that global warming won’t at some point resume. But according to increasing numbers of serious climate scientists, it does suggest that the computer models that have for years been predicting imminent doom, such as those used by the Met Office and the UN Intergovernmental Panel on Climate Change, are flawed, and that the climate is far more complex than the models assert. ‘The new data confirms the existence of a pause in global warming,’ Professor Judith Curry, chair of the School of Earth and Atmospheric Science at America’s Georgia Tech university, told me yesterday. ‘Climate models are very complex, but they are imperfect and incomplete. Natural variability has been shown over the past two decades to have a magnitude that dominates the greenhouse warming effect. ‘It is becoming increasingly apparent that our attribution of warming since 1980 and future projections of climate change needs to consider natural internal variability as a factor of fundamental importance.’ Professor Phil Jones, director of the Climate Research Unit at the University of East Anglia, who found himself at the centre of the ‘Climategate’ scandal over leaked emails three years ago, would not normally be expected to agree with her. Yet on two important points, he did. The data does suggest a plateau, he admitted, and without a major El Nino event – the sudden, dramatic warming of the southern Pacific which takes place unpredictably and always has a huge effect on global weather – ‘it could go on for a while’. Like Prof Curry, Prof Jones also admitted that the climate models were imperfect: ‘We don’t fully understand how to input things like changes in the oceans, and because we don’t fully understand it you could say that natural variability is now working to suppress the warming. We don’t know what natural variability is doing.’ Headache: The evidence is beginning to suggest that global warming may be happening much slower than the catastrophists have claimed - a conclusion with enormous policy implications for politicians at Westminster, pictured Yet he insisted that 15 or 16 years is not a significant period: pauses of such length had always been expected, he said. Yet in 2009, when the plateau was already becoming apparent and being discussed by scientists, he told a colleague in one of the Climategate emails: ‘Bottom line: the “no upward trend” has to continue for a total of 15 years before we get worried.’ But although that point has now been passed, he said that he hadn’t changed his mind about the models’ gloomy predictions: ‘I still think that the current decade which began in 2010 will be warmer by about 0.17 degrees than the previous one, which was warmer than the Nineties.’ Only if that did not happen would he seriously begin to wonder whether something more profound might be happening. In other words, though five years ago he seemed to be saying that 15 years without warming would make him ‘worried’, that period has now become 20 years. Meanwhile, his Met Office colleagues were sticking to their guns. A spokesman said: ‘Choosing a starting or end point on short-term scales can be very misleading. Climate change can only be detected from multi-decadal timescales due to the inherent variability in the climate system.’ He said that for the plateau to last any more than 15 years was ‘unlikely’. Asked about a prediction that the Met Office made in 2009 – that three of the ensuing five years would set a new world temperature record – he made no comment. With no sign of a strong El Nino next year, the prospects of this happening are remote. Why all this matters should be obvious. Every quarter, statistics on the economy’s output and models of future performance have a huge impact on our lives. They trigger a range of policy responses from the Bank of England and the Treasury, and myriad decisions by private businesses. Yet it has steadily become apparent since the 2008 crash that both the statistics and the modelling are extremely unreliable. To plan the future around them makes about as much sense as choosing a wedding date three months’ hence on the basis of a long-term weather forecast. Few people would be so foolish. But decisions of far deeper and more costly significance than those derived from output figures have been and are still being made on the basis of climate predictions, not of the next three months but of the coming century – and this despite the fact that Phil Jones and his colleagues now admit they do not understand the role of ‘natural variability’. The most depressing feature of this debate is that anyone who questions the alarmist, doomsday scenario will automatically be labelled a climate change ‘denier’, and accused of jeopardising the future of humanity. So let’s be clear. Yes: global warming is real, and some of it at least has been caused by the CO2 emitted by fossil fuels. But the evidence is beginning to suggest that it may be happening much slower than the catastrophists have claimed – a conclusion with enormous policy implications. Read more: http://www.dailymail.co.uk/sciencetech/article-2217286/Global-warming-stopped-16-years-ago-reveals-Met-Office-report-quietly-released--chart-prove-it.html#ixzz29TdHPo2l Follow us: @MailOnline on Twitter | DailyMail on Facebook
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Article Title Discipline Rele- vance News- worthiness Pain management for tubal sterilization by hysteroscopy. Cochrane Database Syst Rev Gynecology 5 5 Outcomes of Restrictive Cardiomyopathy in Childhood and the Influence of Phenotype: A Report From the Pediatric Cardiomyopathy Registry. Circulation Surgery - Cardiac 6 6 Bleeding after initiation of multiple antithrombotic drugs, including triple therapy, in atrial fibrillation patients following myocardial infarction and coronary intervention: a nationwide cohort study. Circulation Cardiology 6 5 Hematology/Thrombosis 6 5 Intermittent androgen suppression for rising PSA level after radiotherapy. N Engl J Med Oncology - General 7 7 Randomized, Phase III Study of Gemcitabine or Erlotinib Maintenance Therapy Versus Observation, With Predefined Second-Line Treatment, After Cisplatin-Gemcitabine Induction Chemotherapy in Advanced Non-Small-Cell Lung Cancer. J Clin Oncol Oncology - Lung 7 5 Everolimus-eluting stent versus bare-metal stent in ST-segment elevation myocardial infarction (EXAMINATION): 1 year results of a randomised controlled trial. Lancet Cardiology 5 6 Usefulness of Matrix Metalloproteinase-9 Plasma Levels to Identify Patients With Preserved Left Ventricular Systolic Function After Acute Myocardial Infarction Who Could Benefit from Eplerenone. Am J Cardiol Internal Medicine 5 4 Accuracy of symptoms, signs, and C-reactive protein for early chronic obstructive pulmonary disease. Br J Gen Pract General Practice(GP)/Family Practice(FP) 4 4 General Internal Medicine-Primary Care(US) 4 4 Young Parenthood Program: Supporting Positive Paternal Engagement Through Coparenting Counseling. Am J Public Health Public Health 5 5 Beta-blockers for hypertension. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 7 5 General Internal Medicine-Primary Care(US) 7 5 Progestogens for Preterm Birth Prevention: A Systematic Review and Meta-Analysis. Obstet Gynecol Obstetrics 7 5
Article Title Discipline Rele- vance News- worthiness Purine analogues compared with mesalamine or 5-ASA for the prevention of postoperative recurrence in Crohn`s disease: a meta-analysis. Int J Clin Pract Surgery - Gastrointestinal 5 4 Low oxygen concentrations for embryo culture in assisted reproductive technologies. Cochrane Database Syst Rev Gynecology 6 5 Addition of Gemtuzumab Ozogamicin to Induction Chemotherapy Improves Survival in Older Patients With Acute Myeloid Leukemia. J Clin Oncol Oncology - Hematology 6 6 Randomized clinical trial of antibiotics in acute uncomplicated diverticulitis. Br J Surg Gastroenterology 6 6 Intensive and Standard Blood Pressure Targets in Patients With Type 2 Diabetes Mellitus: Systematic Review and Meta-analysis. Arch Intern Med General Practice(GP)/Family Practice(FP) 7 5 General Internal Medicine-Primary Care(US) 7 5 Internal Medicine 6 5 Nephrology 6 5 Therapeutic platelet transfusion versus routine prophylactic transfusion in patients with haematological malignancies: an open-label, multicentre, randomised study. Lancet Hematology/Thrombosis 7 5 Outcomes with various drug eluting or bare metal stents in patients with diabetes mellitus: mixed treatment comparison analysis of 22 844 patient years of follow-up from randomised trials. BMJ Hospital Doctor/Hospitalists 5 6 Internal Medicine 5 6 General Practice(GP)/Family Practice(FP) 4 5 General Internal Medicine-Primary Care(US) 4 5 Subcutaneous versus intravenous administration of (neo)adjuvant trastuzumab in patients with HER2-positive, clinical stage I-III breast cancer (HannaH study): a phase 3, open-label, multicentre, randomised trial. Lancet Oncol Oncology - Breast 6 5
Article Title Discipline Rele- vance News- worthiness Risk of recurrence of gastrointestinal stromal tumour after surgery: an analysis of pooled population-based cohorts. Lancet Oncol Oncology - Gastrointestinal 6 6 A randomized study of urgent computed tomography-based hematoma puncture and aspiration in the emergency department and subsequent evacuation using craniectomy versus craniectomy only. J Neurosurg Neurology 6 5 Abdominal decompression for suspected fetal compromise/pre-eclampsia. Cochrane Database Syst Rev Pediatric Neonatology 4 4 Changes in the Cerebrospinal Fluid Ceramide Profile After Subarachnoid Hemorrhage. Stroke Surgery - Neurosurgery 5 5 Cost-utility analysis in spine care: a systematic review. Spine J General Practice(GP)/Family Practice(FP) 4 4 General Internal Medicine-Primary Care(US) 4 4 Internal Medicine 3 4 Gefitinib versus placebo as maintenance therapy in patients with locally advanced or metastatic non-small-cell lung cancer (INFORM; C-TONG 0804): a multicentre, double-blind randomised phase 3 trial. Lancet Oncol Respirology/Pulmonology 6 5 Does regular exercise including pelvic floor muscle training prevent urinary and anal incontinence during pregnancy? A randomised controlled trial. BJOG General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Obstetrics 6 4 Ischemic Preconditioning for Prevention of Contrast Medium-Induced Nephropathy: Randomized Pilot RenPro Trial (Renal Protection Trial). Circulation Cardiology 6 6 Thoracic radiotherapy with or without daily low-dose carboplatin in elderly patients with non-small-cell lung cancer: a randomised, controlled, phase 3 trial by the Japan Clinical Oncology Group (JCOG0301). Lancet Oncol Oncology - Lung 7 6 The risk of catheter-related bloodstream infection with femoral venous catheters as compared to subclavian and internal jugular venous catheters: A systematic review of the literature and meta-analysis*. Crit Care Med Infectious Disease 6 6 Antiretroviral pre-exposure prophylaxis (PrEP) for preventing HIV in high-risk individuals. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6 Infectious Disease 6 4
Article Title Discipline Rele- vance News- worthiness A midurethral sling to reduce incontinence after vaginal prolapse repair. N Engl J Med Gynecology 6 6 Relapse and disability outcomes in patients with multiple sclerosis treated with fingolimod: subgroup analyses of the double-blind, randomised, placebo-controlled FREEDOMS study. Lancet Neurol Neurology 5 5 Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial. Lancet Oncol Oncology - Lung 7 6 Maintenance therapy with pemetrexed plus best supportive care versus placebo plus best supportive care after induction therapy with pemetrexed plus cisplatin for advanced non-squamous non-small-cell lung cancer (PARAMOUNT): a double-blind, phase 3, randomised controlled trial. Lancet Oncol Oncology - Lung 6 6 Respirology/Pulmonology 5 5 Intravenous lidocaine for the treatment of background or procedural burn pain. Cochrane Database Syst Rev Intensivist/Critical Care 4 4 No specific effect of whole-body vibration training in chronic stroke: a double-blind randomized controlled study. Arch Phys Med Rehabil Physical Medicine and Rehabilitation 4 4 First-Line Erlotinib Followed by Second-Line Cisplatin-Gemcitabine Chemotherapy in Advanced Non-Small-Cell Lung Cancer: The TORCH Randomized Trial. J Clin Oncol Oncology - Lung 6 6 Mobile phone messaging reminders for attendance at healthcare appointments. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 5 4 General Internal Medicine-Primary Care(US) 5 4 Splinting for carpal tunnel syndrome. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Rheumatology 5 5
Article Title Discipline Rele- vance News- worthiness The effectiveness of a standardised preoperative preparation in reducing child and parent anxiety: a single-blind randomised controlled trial. J Clin Nurs Pediatrics (General) 6 5 Citalopram versus other anti-depressive agents for depression. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Haematogenous acute and subacute paediatric osteomyelitis: a systematic review of the literature. J Bone Joint Surg Br Pediatric Emergency Medicine 6 6 Emergency Medicine 6 5 HIV Prevention Interventions to Reduce Racial Disparities in the United States: A Systematic Review. J Gen Intern Med Infectious Disease 4 4 Sentinel Lymph Node Biopsy for Melanoma: American Society of Clinical Oncology and Society of Surgical Oncology Joint Clinical Practice Guideline. J Clin Oncol Surgery - Oncology 6 4 Polyunsaturated fatty acids (PUFA) for attention deficit hyperactivity disorder (ADHD) in children and adolescents. Cochrane Database Syst Rev Pediatrics (General) 6 5 Psychiatry 6 5 Preexposure Prophylaxis for HIV Infection among African Women. N Engl J Med General Practice(GP)/Family Practice(FP) 5 6 General Internal Medicine-Primary Care(US) 5 6 Antiretroviral Prophylaxis for HIV Prevention in Heterosexual Men and Women. N Engl J Med General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6 Efficacy of psychosocial intervention in patients with mild Alzheimer`s disease: the multicentre, rater blinded, randomised Danish Alzheimer Intervention Study (DAISY). BMJ Neurology 6 5 Geriatrics 5 5 Tiotropium versus placebo for chronic obstructive pulmonary disease. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Internal Medicine 5 4
Article Title Discipline Rele- vance News- worthiness Hemoglobin A1c Versus Oral Glucose Tolerance Test in Postpartum Diabetes Screening. Diabetes Care Endocrine 4 4 General Practice(GP)/Family Practice(FP) 3 3 General Internal Medicine-Primary Care(US) 3 3 Second trimester serum tests for Down`s Syndrome screening. Cochrane Database Syst Rev Obstetrics 6 5 GP/FP/Obstetrics 5 4 Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate versus ritonavir-boosted atazanavir plus co-formulated emtricitabine and tenofovir disoproxil fumarate for initial treatment of HIV-1 infection: a randomised, double-blind, phase 3, non-inferiority trial. Lancet Infectious Disease 6 5 Randomized Phase II Study of Dacomitinib (PF-00299804), an Irreversible Pan-Human Epidermal Growth Factor Receptor Inhibitor, Versus Erlotinib in Patients With Advanced Non-Small-Cell Lung Cancer. J Clin Oncol Oncology - Lung 7 6 Effects of music on depression in older people: a randomised controlled trial. J Clin Nurs Geriatrics 5 4 General Practice(GP)/Family Practice(FP) 4 3 General Internal Medicine-Primary Care(US) 4 3 Does a Coeliac School increase psychological well-being in women suffering from coeliac disease, living on a gluten-free diet?. J Clin Nurs Gastroenterology 4 5 General Practice(GP)/Family Practice(FP) 4 3 General Internal Medicine-Primary Care(US) 4 3 Effects of music therapy on anxiety of patients with breast cancer after radical mastectomy: a randomized clinical trial. J Adv Nurs GP/FP/Mental Health 5 5 Oncology - General 3 3 Psychological interventions for symptomatic management of non-specific chest pain in patients with normal coronary anatomy. Cochrane Database Syst Rev Psychiatry 6 3 General Internal Medicine-Primary Care(US) 5 4 General Practice(GP)/Family Practice(FP) 5 4 GP/FP/Mental Health 5 3 Peri-implantation glucocorticoid administration for assisted reproductive technology cycles. Cochrane Database Syst Rev Obstetrics 5 4 Noninvasive Single-Exon Fetal RHD Determination in a Routine Screening Program in Early Pregnancy. Obstet Gynecol Obstetrics 7 7 Effect of Adenosine-Regulating Agent Acadesine on Morbidity and Mortality Associated With Coronary Artery Bypass Grafting: The RED-CABG Randomized Controlled Trial. JAMA Cardiology 4 4 Metal-on-Metal vs Conventional Total Hip Arthroplasty: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Arthroplasty Surgery - Orthopaedics 6 4 Outcome After Mobilization Within 24 Hours of Acute Stroke: A Randomized Controlled Trial. Stroke Physical Medicine and Rehabilitation 7 7 Neurology 5 5 Risk of adverse fetal outcomes following administration of a pandemic influenza A(H1N1) vaccine during pregnancy. JAMA Public Health 6 6 Efficacy and safety of pharmacotherapy for smoking cessation among pregnant smokers: a meta-analysis. BJOG General Practice(GP)/Family Practice(FP) 5 4 Diagnostic accuracy of clinical tests for subacromial impingement syndrome: a systematic review and meta-analysis. Arch Phys Med Rehabil Surgery - Orthopaedics 6 5 Meditation or Exercise for Preventing Acute Respiratory Infection: A Randomized Controlled Trial. Ann Fam Med General Practice(GP)/Family Practice(FP) 5 7 General Internal Medicine-Primary Care(US) 5 7 Respirology/Pulmonology 3 3
Article Title Discipline Rele- vance News- worthiness Prevention of postpartum haemorrhage with sublingual misoprostol or oxytocin: a double-blind randomised controlled trial. BJOG Obstetrics 7 6 Transcranial direct current stimulation for the reduction of clinical and experimentally induced pain: a systematic review and meta-analysis. Clin J Pain Neurology 4 4 General Practice(GP)/Family Practice(FP) 3 3 General Internal Medicine-Primary Care(US) 3 3 Hyperfractionated or Accelerated Radiotherapy in Lung Cancer: An Individual Patient Data Meta-Analysis. J Clin Oncol Oncology - Lung 5 5 Custom foot orthoses for rheumatoid arthritis: A systematic review. Arthritis Care Res (Hoboken) Rheumatology 5 4 Incidence, Event Rates, and Early Outcome of Stroke in Dublin, Ireland: The North Dublin Population Stroke Study. Stroke Hospital Doctor/Hospitalists 4 4 Internal Medicine 4 4 A Randomized Trial to Reduce the Prevalence of Depression and Self-Harm Behavior in Older Primary Care Patients. Ann Fam Med General Practice(GP)/Family Practice(FP) 5 4 GP/FP/Mental Health 5 4 General Internal Medicine-Primary Care(US) 5 4 Combined Femoral and Sciatic Nerve Block vs Combined Femoral and Periarticular Infiltration in Total Knee Arthroplasty: A Randomized Controlled Trial. J Arthroplasty Surgery - Orthopaedics 5 4 Oral care with 0.12% chlorhexidine for the prevention of ventilator-associated pneumonia in critically ill children: Randomised, controlled and double blind trial. Int J Nurs Stud Pediatrics (General) 4 4 Amiodarone versus lidocaine and placebo for the prevention of ventricular fibrillation after aortic crossclamping: A randomized, double-blind, placebo-controlled trial. J Thorac Cardiovasc Surg Cardiology 5 4 Audit and feedback: effects on professional practice and healthcare outcomes. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6 Outcome of Patients Who Refuse Transfusion After Cardiac Surgery: A Natural Experiment With Severe Blood Conservation. Outcome of Patients Who Refuse Transfusion. Arch Intern Med Hospital Doctor/Hospitalists 6 6 Internal Medicine 6 6 Hematology/Thrombosis 6 5 Multicenter randomized controlled trial comparing early versus late aquatic therapy after total hip or knee arthroplasty. Arch Phys Med Rehabil Surgery - Orthopaedics 4 5 Effect of exercise on physical function, daily living activities, and quality of life in the frail older adults: a meta-analysis. Arch Phys Med Rehabil General Practice(GP)/Family Practice(FP) 5 4 General Internal Medicine-Primary Care(US) 5 4 Combined intensive blood pressure and glycemic control does not produce an additive benefit on microvascular outcomes in type 2 diabetic patients. Kidney Int Endocrine 7 6 General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5
Article Title Discipline Rele- vance News- worthiness Rifaximin-extended intestinal release induces remission in patients with moderately active Crohn`s disease. Gastroenterology Gastroenterology 5 6 Mortality and implant revision rates of hip arthroplasty in patients with osteoarthritis: registry based cohort study. BMJ Surgery - Orthopaedics 5 4 Spica Casting for Pediatric Femoral Fractures: A Prospective, Randomized Controlled Study of Single-Leg Versus Double-Leg Spica Casts. J Bone Joint Surg Am Surgery - Orthopaedics 6 5 Losigamone add-on therapy for partial epilepsy. Cochrane Database Syst Rev Neurology 5 4 Secondary Prophylaxis of Hepatic Encephalopathy in Cirrhosis: An Open-Label, Randomized Controlled Trial of Lactulose, Probiotics, and No Therapy. Am J Gastroenterol Gastroenterology 6 5 Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial. Lancet Oncology - General 6 5 Effects of Telerehabilitation on Physical Function and Disability for Stroke Patients: A Randomized, Controlled Trial. Stroke Neurology 5 4 Sensitivity of Magnetic Resonance Imaging for Detection of Patellofemoral Articular Cartilage Defects. Arthroscopy Surgery - Orthopaedics 5 4 Intensive Versus Subcutaneous Insulin in Patients With Hyperacute Stroke: Results From the Randomized INSULINFARCT Trial. Stroke Hospital Doctor/Hospitalists 7 7 Internal Medicine 7 7
Article Title Discipline Rele- vance News- worthiness Colloids versus crystalloids for fluid resuscitation in critically ill patients. Cochrane Database Syst Rev Intensivist/Critical Care 6 6 Cranberry-Containing Products for Prevention of Urinary Tract Infections in Susceptible Populations: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Arch Intern Med General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Hospital Doctor/Hospitalists 6 4 Internal Medicine 6 4 Cannabinoids for epilepsy. Cochrane Database Syst Rev Neurology 4 4
Article Title Discipline Rele- vance News- worthiness Emphysema scores predict death from COPD and lung cancer. Chest Internal Medicine 6 6 Oncology - Lung 5 4 Quantitative PCR to diagnose Pneumocystis pneumonia in immunocompromised non-HIV patients. Eur Respir J Respirology/Pulmonology 5 5 Usefulness of cardiac computed tomographic delayed contrast enhancement of the left atrial appendage before pulmonary vein ablation. Am J Cardiol Cardiology 4 5 Adverse events with intravitreal injection of vascular endothelial growth factor inhibitors: nested case-control study. BMJ Surgery - Ophthalmology 6 4 Relation of diagonal ear lobe crease to the presence, extent, and severity of coronary artery disease determined by coronary computed tomography angiography. Am J Cardiol General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Influence of exercise on mood in postmenopausal women. J Clin Nurs Psychiatry 5 5 Bone density and structure in healthy postmenopausal women treated with exemestane for the primary prevention of breast cancer: a nested substudy of the MAP.3 randomised controlled trial. Lancet Oncol Endocrine 6 5 General Practice(GP)/Family Practice(FP) 4 5 General Internal Medicine-Primary Care(US) 4 5 Cognitive stimulation during hospitalization improves global cognition of older Taiwanese undergoing elective total knee and hip replacement surgery. J Adv Nurs Psychiatry 6 5 Regimens of fetal surveillance for impaired fetal growth. Cochrane Database Syst Rev Obstetrics 4 4 Healthcare financing systems for increasing the use of tobacco dependence treatment. Cochrane Database Syst Rev Respirology/Pulmonology 5 4
Article Title Discipline Rele- vance News- worthiness The clinical utility and diagnostic performance of MRI for identification and classification of knee osteochondritis dissecans. J Bone Joint Surg Am Surgery - Orthopaedics 5 4 Overall Survival Benefit With Lapatinib in Combination With Trastuzumab for Patients With Human Epidermal Growth Factor Receptor 2-Positive Metastatic Breast Cancer: Final Results From the EGF104900 Study. J Clin Oncol Oncology - Breast 6 5 Early antibiotic treatment for Pseudomonas aeruginosa eradication in patients with cystic fibrosis: a randomised multicentre study comparing two different protocols. Thorax Respirology/Pulmonology 6 6 Non-CPAP therapies in obstructive sleep apnoea: mandibular advancement device therapy. Eur Respir J General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Long-term outcome of aortic dissection with patent false lumen: predictive role of entry tear size and location. Circulation Surgery - Vascular 6 5 Predicting the adverse risk of statin treatment: an independent and external validation of Qstatin risk scores in the UK. Heart General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6 Nephrology 5 6 Effects of fish oil supplementation on cardiac function in chronic heart failure: a meta-analysis of randomised controlled trials. Heart General Practice(GP)/Family Practice(FP) 7 6 General Internal Medicine-Primary Care(US) 7 6 Minimising preoperative anxiety with music for day surgery patients - a randomised clinical trial. J Clin Nurs Surgery - General 4 4 The cost-effectiveness of substituting physicians with diabetes nurse specialists: a randomized controlled trial with 2-year follow-up. J Adv Nurs Endocrine 4 4 Conservative management of patients with an osteoporotic vertebral fracture: a review of the literature. J Bone Joint Surg Br Surgery - Orthopaedics 6 6 Geriatrics 6 5 Water for preventing urinary stones. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 6 4 General Internal Medicine-Primary Care(US) 6 4 Somatostatin analogues for pancreatic surgery. Cochrane Database Syst Rev Gastroenterology 5 5 Modified Phalen`s test as an aid in diagnosing carpal tunnel syndrome. Arthritis Care Res (Hoboken) General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6
Article Title Discipline Rele- vance News- worthiness Recompression and adjunctive therapy for decompression illness. Cochrane Database Syst Rev Emergency Medicine 4 4 Herbal medicines for advanced colorectal cancer. Cochrane Database Syst Rev Oncology - Gastrointestinal 5 6 Angiotensin II Receptor Blocker-based Therapy in Japanese Elderly, High-risk, Hypertensive Patients. Am J Med Geriatrics 4 4 A strategy combining imaging and laboratory biomarkers in comparison with a simplified clinical score for risk stratification of patients with acute pulmonary embolism. Chest Emergency Medicine 5 5 Effect of insulin sensitizer therapy on atherothrombotic and inflammatory profiles associated with insulin resistance. Mayo Clin Proc Endocrine 4 4 Diagnosis and treatment of patients with stroke in a mobile stroke unit versus in hospital: a randomised controlled trial. Lancet Neurol Emergency Medicine 4 4 Effect of High-Dose Erythropoietin on Graft Function after Kidney Transplantation: A Randomized, Double-Blind Clinical Trial. Clin J Am Soc Nephrol Nephrology 5 4 Antifungal therapy for newborn infants with invasive fungal infection. Cochrane Database Syst Rev Pediatric Neonatology 7 5 Bronchodilators for the prevention and treatment of chronic lung disease in preterm infants. Cochrane Database Syst Rev Pediatric Neonatology 6 4 Preoperative Diagnosis of Benign Thyroid Nodules with Indeterminate Cytology. N Engl J Med Endocrine 6 6 Community-based supplementary feeding for promoting the growth of children under five years of age in low and middle income countries. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 4 4 Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir versus co-formulated efavirenz, emtricitabine, and tenofovir for initial treatment of HIV-1 infection: a randomised, double-blind, phase 3 trial, analysis of results after 48 weeks. Lancet Internal Medicine 6 5 Evaluation of a bibliotherapy manual for reducing psychological distress in people with depression: a randomized controlled trial. J Adv Nurs Psychiatry 6 6 Effectiveness of amiodarone versus bepridil in achieving conversion to sinus rhythm in patients with persistent atrial fibrillation: a randomised trial. Heart Cardiology 4 5 Statin Therapy and the Risk of Intracerebral Hemorrhage: A Meta-Analysis of 31 Randomized Controlled Trials. Stroke General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Cardiology 4 4
Article Title Discipline Rele- vance News- worthiness Immunotherapy for IgM anti-myelin-associated glycoprotein paraprotein-associated peripheral neuropathies. Cochrane Database Syst Rev Neurology 6 4 Effective delivery styles and content for self-management interventions for chronic musculoskeletal pain: a systematic literature review. Clin J Pain General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6 HIV infection and the incidence of malaria among HIV-exposed children from Tanzania. J Infect Dis Pediatrics (General) 6 6 Tropical and Travel Medicine 6 5 Intermittent recruitment with high-frequency oscillation/tracheal gas insufflation in acute respiratory distress syndrome. Eur Respir J Hospital Doctor/Hospitalists 4 4 Internal Medicine 4 4 High-sensitivity cardiac troponin in the distinction of acute myocardial infarction from acute cardiac noncoronary artery disease. Circulation Cardiology 6 6 Caesarean section versus vaginal delivery for preterm birth in singletons. Cochrane Database Syst Rev Pediatric Neonatology 6 5 Routinely available biomarkers improve prediction of long-term mortality in stable coronary artery disease: the Vienna and Ludwigshafen Coronary Artery Disease (VILCAD) risk score. Eur Heart J General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 Thirty-day rehospitalizations after acute myocardial infarction: a cohort study. Ann Intern Med Cardiology 6 4 Hospital Doctor/Hospitalists 5 5 Internal Medicine 5 5 Trajectory of Functional Decline Before and After Ischemic Stroke: The Northern Manhattan Study. Stroke Neurology 6 5 General Practice(GP)/Family Practice(FP) 4 4 General Internal Medicine-Primary Care(US) 4 4
Article Title Discipline Rele- vance News- worthiness Viscosupplementation for Osteoarthritis of the Knee: A Systematic Review and Meta-analysis. Ann Intern Med General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Hemiarthroplasty of the hip with and without cement: a randomized clinical trial. J Bone Joint Surg Am Surgery - Orthopaedics 7 5 Directly Observed Antidepressant Medication Treatment and HIV Outcomes Among Homeless and Marginally Housed HIV-Positive Adults: A Randomized Controlled Trial. Am J Public Health GP/FP/Mental Health 5 5 Ganoderma lucidum (Reishi mushroom) for cancer treatment. Cochrane Database Syst Rev Oncology - Gastrointestinal 6 5 Multicenter, Randomized, Open-Label, Phase III Trial of Decitabine Versus Patient Choice, With Physician Advice, of Either Supportive Care or Low-Dose Cytarabine for the Treatment of Older Patients With Newly Diagnosed Acute Myeloid Leukemia. J Clin Oncol Oncology - Hematology 5 5 Exercise and mobilisation interventions for carpal tunnel syndrome. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 6 4 General Internal Medicine-Primary Care(US) 6 4 Artesunate versus quinine for treating severe malaria. Cochrane Database Syst Rev Infectious Disease 7 5 An international model to predict recurrent cardiovascular disease. Am J Med General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 Duloxetine for the management of pain in older adults with knee osteoarthritis: randomised placebo-controlled trial. Age Ageing General Practice(GP)/Family Practice(FP) 7 6 General Internal Medicine-Primary Care(US) 7 6 Rheumatology 6 6 Colloid solutions for fluid resuscitation. Cochrane Database Syst Rev Pediatric Emergency Medicine 6 6 Surgery - Vascular 6 5 Hospital Doctor/Hospitalists 6 5 Internal Medicine 6 5 Surgery - General 6 5 Surgery - Oncology 4 4 Red Blood Cell Transfusion: A Clinical Practice Guideline From the AABB. Ann Intern Med Surgery - General 7 4 Hematology/Thrombosis 6 5 Group-based parent training programmes for improving parental psychosocial health. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 4 4 Endoscopic Clip-Assisted Feeding Tube Placement Reduces Repeat Endoscopy Rate: Results from a Randomized Controlled Trial. Am J Gastroenterol Hospital Doctor/Hospitalists 5 4 Internal Medicine 5 4 Early administration of aspirin in patients treated with alteplase for acute ischaemic stroke: a randomised controlled trial. Lancet Neurology 6 5
Article Title Discipline Rele- vance News- worthiness The Effects of Health Care Benefits on Health Care Use and Health: A Randomized Trial for Disability Insurance Beneficiaries. Med Care Public Health 6 6 Fish consumption, dietary long-chain n-3 fatty acids, and risk of type 2 diabetes: systematic review and meta-analysis of prospective studies. Diabetes Care Endocrine 5 5 Comparison between suture anchor and transosseous suture for the modified-Brostr鰉 procedure. Foot Ankle Int Surgery - Orthopaedics 5 4 Dabigatran, rivaroxaban, or apixaban versus enoxaparin for thromboprophylaxis after total hip or knee replacement: systematic review, meta-analysis, and indirect treatment comparisons. BMJ Hematology/Thrombosis 6 5 Monosodium glutamate avoidance for chronic asthma in adults and children. Cochrane Database Syst Rev Allergy and Immunology 6 4 General Practice(GP)/Family Practice(FP) 4 3 General Internal Medicine-Primary Care(US) 4 3 The Effectiveness of a Group-Based Acceptance and Commitment Additive Therapy on Rehabilitation of Female Outpatients With Chronic Headache: Preliminary Findings Reducing 3 Dimensions of Headache Impact. Headache GP/FP/Mental Health 6 6 General Internal Medicine-Primary Care(US) 3 4 General Practice(GP)/Family Practice(FP) 3 4 Neurology 3 3 The Efficacy of a Thrombin-Based Hemostatic Agent in Unilateral Total Knee Arthroplasty: A Randomized Controlled Trial. J Bone Joint Surg Am Anesthesiology 6 6 Diagnostic accuracy of ultrasonography in the acute assessment of common thoracic lesions after trauma. Chest Emergency Medicine 7 6 Respirology/Pulmonology 6 6 Surgical interventions for treating acute achilles tendon rupture: key findings from a recent cochrane review. J Bone Joint Surg Am Surgery - Orthopaedics 7 6 A Simple Screening Score for Diabetes for the Korean Population: Development, validation, and comparison with other scores. Diabetes Care General Practice(GP)/Family Practice(FP) 5 4 General Internal Medicine-Primary Care(US) 5 4
Article Title Discipline Rele- vance News- worthiness Diagnostic accuracy of visual urethral mobility exam versus Q-Tip test: a randomized crossover trial. Am J Obstet Gynecol Gynecology 7 6 Short- and long-term outcomes with drug-eluting and bare-metal coronary stents: a mixed-treatment comparison analysis of 117 762 patient-years of follow-up from randomized trials. Circulation Cardiology 6 6 Topical microbicides for prevention of sexually transmitted infections. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 6 3 General Internal Medicine-Primary Care(US) 6 3 Infectious Disease 5 5 Intensive Glycemic Control Is Not Associated With Fractures or Falls in the ACCORD Randomized Trial. Diabetes Care General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 Endocrine 5 5 Effect of a 3-Step Critical Pathway to Reduce Duration of Intravenous Antibiotic Therapy and Length of Stay in Community-Acquired Pneumonia: A Randomized Controlled TrialA 3-Step Critical Pathway for CAP. Arch Intern Med Infectious Disease 6 5 Hospital Doctor/Hospitalists 5 5 Internal Medicine 5 5
Article Title Discipline Rele- vance News- worthiness Morphine and Ketamine Is Superior to Morphine Alone for Out-of-Hospital Trauma Analgesia: A Randomized Controlled Trial. Ann Emerg Med Emergency Medicine 6 7 Sleep apnea and risk of deep vein thrombosis: a non-randomized, pair-matched cohort study. Am J Med Internal Medicine 6 5 A randomized trial of preinduction cervical ripening: dinoprostone vaginal insert versus double-balloon catheter. Am J Obstet Gynecol GP/FP/Obstetrics 6 5 Effects of Dapagliflozin, a Sodium-Glucose Cotransporter-2 Inhibitor, on Hemoglobin A1c, Body Weight, and Hypoglycemia Risk in Patients With Type 2 Diabetes Inadequately Controlled on Pioglitazone Monotherapy. Diabetes Care Endocrine 6 6 Basal Insulin and Cardiovascular and Other Outcomes in Dysglycemia. N Engl J Med Internal Medicine 5 6 Telemedicine for the support of parents of high-risk newborn infants. Cochrane Database Syst Rev Pediatrics (General) 6 3 Pediatric Neonatology 4 4 Predicting the 10 year risk of cardiovascular disease in the United Kingdom: independent and external validation of an updated version of QRISK2. BMJ General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6 Internal Medicine 6 5
Article Title Discipline Rele- vance News- worthiness Chinese herbal medicine for endometriosis. Cochrane Database Syst Rev Gynecology 5 4 Extracorporeal shock wave lithotripsy (ESWL) versus ureteroscopic management for ureteric calculi. Cochrane Database Syst Rev Surgery - Urology 6 4 Screening for dysglycemia in overweight youth presenting for weight management. Diabetes Care Endocrine 6 5 Ibuprofen Prevents Altitude Illness: A Randomized Controlled Trial for Prevention of Altitude Illness With Nonsteroidal Anti-inflammatories. Ann Emerg Med Tropical and Travel Medicine 5 5 An admission bioclinical score to predict 1-year outcomes in patients undergoing aneurysm coiling. Stroke Neurology 6 5 Speech and language therapy for aphasia following stroke. Cochrane Database Syst Rev Neurology 7 5 Whole-heart dynamic three-dimensional magnetic resonance perfusion imaging for the detection of coronary artery disease defined by fractional flow reserve: determination of volumetric myocardial ischaemic burden and coronary lesion location. Eur Heart J Cardiology 6 6 Interventions for smoking cessation in hospitalised patients. Cochrane Database Syst Rev Respirology/Pulmonology 6 5 Hospital Doctor/Hospitalists 5 5 Internal Medicine 5 5 Nutritional support for liver disease. Cochrane Database Syst Rev Hospital Doctor/Hospitalists 5 5 Internal Medicine 5 5 A Sumatriptan Iontophoretic Transdermal System for the Acute Treatment of Migraine. Headache Neurology 5 4 Effectiveness of anterior cruciate ligament injury prevention training programs. J Bone Joint Surg Am General Practice(GP)/Family Practice(FP) 5 4 General Internal Medicine-Primary Care(US) 5 4 Remote Monitoring Reduces Healthcare Use and Improves Quality of Care in Heart Failure Patients With Implantable Defibrillators: The Evolution of Management Strategies of Heart Failure Patients With Implantable Defibrillators (EVOLVO) Study. Circulation Cardiology 6 7
Article Title Discipline Rele- vance News- worthiness Long-Term Results of CCG 5942: A Randomized Comparison of Chemotherapy With and Without Radiotherapy for Children With Hodgkin`s Lymphoma--A Report From the Children`s Oncology Group. J Clin Oncol Oncology - Hematology 6 6 Anti-leukotriene agents compared to inhaled corticosteroids in the management of recurrent and/or chronic asthma in adults and children. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Hospital at home for acute exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev Emergency Medicine 6 5 Respirology/Pulmonology 6 5 Hospital Doctor/Hospitalists 5 5 Internal Medicine 5 5 Hyperbaric oxygen therapy for late radiation tissue injury. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 Oncology - Gastrointestinal 5 5 Oncology - General 5 4 Concurrent Validity of Ages and Stages Questionnaires in Preterm Infants. Pediatrics Pediatrics (General) 6 5 General Practice(GP)/Family Practice(FP) 3 4 Internet based vascular risk factor management for patients with clinically manifest vascular disease: randomised controlled trial. BMJ General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 Cardiology 4 4 Assessment of patient-led or physician-driven continuous glucose monitoring in patients with poorly controlled type 1 diabetes using basal-bolus insulin regimens: a 1-year multicenter study. Diabetes Care General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 Chemotherapy for brain metastases from small cell lung cancer. Cochrane Database Syst Rev Oncology - Lung 6 5 Short-term versus long-term antiarrhythmic drug treatment after cardioversion of atrial fibrillation (Flec-SL): a prospective, randomised, open-label, blinded endpoint assessment trial. Lancet Cardiology 5 5 Internal Medicine 5 4 Paliperidone palmitate for schizophrenia. Cochrane Database Syst Rev Psychiatry 7 5 Long-acting FSH versus daily FSH for women undergoing assisted reproduction. Cochrane Database Syst Rev Gynecology 7 6 The Application of the Diabetes Prevention Trial-Type 1 Risk Score for Identifying a Preclinical State of Type 1 Diabetes. Diabetes Care Endocrine 5 5
Article Title Discipline Rele- vance News- worthiness Head-to-Head Comparison of Left Ventricular Function Assessment with 64-Row Computed Tomography, Biplane Left Cineventriculography, and Both 2- and 3-Dimensional Transthoracic Echocardiography: Comparison With Magnetic Resonance Imaging as the Reference Standard. J Am Coll Cardiol Cardiology 5 4 Cost-Effectiveness of Everolimus- Versus Paclitaxel-Eluting Stents for Patients Undergoing Percutaneous Coronary Revascularization (from the SPIRIT-IV Trial).P. Am J Cardiol Cardiology 5 4 Prediction at first year of incident new-onset diabetes after kidney transplantation by risk prediction models. Diabetes Care Nephrology 6 5 Endocrine 5 4 Training health professionals in smoking cessation. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Elective birth at 37 weeks of gestation versus standard care for women with an uncomplicated twin pregnancy at term: the Twins Timing of Birth Randomised Trial. BJOG Obstetrics 6 5 Dose-Ranging Effects of Canagliflozin, a Sodium-Glucose Cotransporter 2 Inhibitor, as Add-On to Metformin in Subjects With Type 2 Diabetes. Diabetes Care Endocrine 6 6 Metabolic Effects of Replacing Sucrose by Isomaltulose in Subjects With Type 2 Diabetes: A randomized double-blind trial. Diabetes Care Endocrine 5 5 General Practice(GP)/Family Practice(FP) 4 4 General Internal Medicine-Primary Care(US) 4 4 High burden of kidney disease in youth-onset type 2 diabetes. Diabetes Care Nephrology 6 5 The Role of Platelet-Rich Plasma in Arthroscopic Rotator Cuff Repair: A Systematic Review With Quantitative Synthesis. Arthroscopy Surgery - Orthopaedics 6 6 Tranexamic Acid for Reduction of Blood Loss During Total Hip Arthroplasty. J Arthroplasty Surgery - Orthopaedics 6 5 Anesthesiology 6 5 Association of Aspirin Use With Major Bleeding in Patients With and Without Diabetes. Aspirin Use and Major Bleeding in Diabetes. JAMA Hematology/Thrombosis 5 5 Internal Medicine 5 4 Ticagrelor Versus Clopidogrel in Patients With Acute Coronary Syndromes and a History of Stroke or Transient Ischemic Attack. Circulation Internal Medicine 5 5 Maternal Exercise and Growth in Breastfed Infants: A Meta-analysis of Randomized Controlled Trials. Pediatrics General Practice(GP)/Family Practice(FP) 5 4 General Internal Medicine-Primary Care(US) 5 4 Motion versus fixed distraction of the joint in the treatment of ankle osteoarthritis: a prospective randomized controlled trial. J Bone Joint Surg Am Surgery - Orthopaedics 6 6 Long-Term Comparison of Fixed-Bearing and Mobile-Bearing Total Knee Replacements in Patients Younger Than Fifty-one Years of Age with Osteoarthritis. J Bone Joint Surg Am Surgery - Orthopaedics 6 5 Antioxidant vitamin supplementation for preventing and slowing the progression of age-related cataract. Cochrane Database Syst Rev Surgery - Ophthalmology 6 4 Body positioning for spontaneously breathing preterm infants with apnoea. Cochrane Database Syst Rev Pediatric Hospital Medicine 6 5 Benefits and harms of pharmacologic treatment for urinary incontinence in women: a systematic review. Ann Intern Med Geriatrics 6 6 General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Gynecology 5 5 Surgery - Urology 5 5 Risk of acute coronary syndrome in elderly users of antipsychotic drugs: a nested case-control study. Heart Geriatrics 6 4 Prediction model to estimate presence of coronary artery disease: retrospective pooled analysis of existing cohorts. BMJ Cardiology 6 5 n-3 Fatty Acids and Cardiovascular Outcomes in Patients with Dysglycemia. N Engl J Med General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6 Ideal cardiovascular health predicts lower risks of myocardial infarction, stroke, and vascular death across whites, blacks, and hispanics: the northern Manhattan study. Circulation General Practice(GP)/Family Practice(FP) 6 4 General Internal Medicine-Primary Care(US) 6 4 Cardiology 6 4 Effectiveness and Safety of Tranexamic Acid in Reducing Blood Loss in Total Knee Arthroplasty: A Meta-Analysis. J Bone Joint Surg Am Anesthesiology 7 5 Surgery - Orthopaedics 6 6 Simple score to assess the risk of rejection after orthotopic heart transplantation. Circulation Surgery - Cardiac 5 6 Cardiology 5 4 Sedative techniques for endoscopic retrograde cholangiopancreatography. Cochrane Database Syst Rev Surgery - Gastrointestinal 5 4 Anesthesiology 5 4 Sequential Intensification of Metformin Treatment in Type 2 Diabetes With Liraglutide Followed by Randomized Addition of Basal Insulin Prompted by A1C Targets. Diabetes Care Internal Medicine 6 6 Radiofrequency ablation in the treatment of liver metastases from colorectal cancer. Cochrane Database Syst Rev Surgery - Oncology 6 6 Oncology - Gastrointestinal 5 5 Screening for cognitive impairment: comparing the performance of four instruments in primary care. J Am Geriatr Soc Geriatrics 6 4
Article Title Discipline Rele- vance News- worthiness Dapagliflozin, metformin XR, or both: initial pharmacotherapy for type 2 diabetes, a randomised controlled trial. Int J Clin Pract Internal Medicine 7 7 Residual flow after cerebral aneurysm coil occlusion: diagnostic accuracy of MR angiography. Stroke Surgery - Neurosurgery 6 4 Spuriously high prevalence of prediabetes diagnosed by HbA(1c) in young indians partly explained by hematological factors and iron deficiency anemia. Diabetes Care General Practice(GP)/Family Practice(FP) 5 6 General Internal Medicine-Primary Care(US) 5 6 Radiotherapy and chemoradiation after surgery for early cervical cancer. Cochrane Database Syst Rev Gynecology 6 5 Outcome Trajectories in Extremely Preterm Infants. Pediatrics Pediatric Neonatology 6 5 Safety of laparoscopy vs laparotomy in the surgical staging of endometrial cancer: a systematic review and metaanalysis of randomized controlled trials. Am J Obstet Gynecol Gynecology 7 5 Surgery - Oncology 5 4 The iScore predicts effectiveness of thrombolytic therapy for acute ischemic stroke. Stroke Neurology 6 5 Interventions for female pattern hair loss. Cochrane Database Syst Rev Dermatology 7 3 General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 Development and validation of a dispatcher identification algorithm for stroke emergencies. Stroke Neurology 5 4 A risk score for chronic kidney disease in the general population. Am J Med General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Delirium screening in critically ill patients: A systematic review and meta-analysis. Crit Care Med Geriatrics 6 4 Intensivist/Critical Care 5 5 Meta-Analysis of Effect of Dipeptidyl Peptidase-4 Inhibitors on Cardiovascular Risk in Type 2 Diabetes Mellitus. Am J Cardiol General Practice(GP)/Family Practice(FP) 7 6 General Internal Medicine-Primary Care(US) 7 6 Enhanced glucose control for preventing and treating diabetic neuropathy. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 7 5 General Internal Medicine-Primary Care(US) 7 5 Evaluation of harm in the pharmacotherapy of irritable bowel syndrome. Am J Med General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 Gastroenterology 5 5
Article Title Discipline Rele- vance News- worthiness Alemtuzumab Induction Therapy in Kidney Transplantation: A Systematic Review and Meta-Analysis. Transplantation Nephrology 6 6 Individual patient data subgroup meta-analysis of surgery for spontaneous supratentorial intracerebral hemorrhage. Stroke Neurology 6 6 The effect of virtual reality gaming on dynamic balance in older adults. Age Ageing Geriatrics 5 4 Perioperative Administration of Selective Cyclooxygenase-2 Inhibitors for Postoperative Pain Management in Patients After Total Knee Arthroplasty. J Arthroplasty Surgery - Orthopaedics 5 5 Treatment With B Vitamins and Incidence of Cancer in Patients With Previous Stroke or Transient Ischemic Attack: Results of a Randomized Placebo-Controlled Trial. Stroke General Practice(GP)/Family Practice(FP) 5 4 General Internal Medicine-Primary Care(US) 5 4 Bisphosphonates in multiple myeloma: a network meta-analysis. Cochrane Database Syst Rev Oncology - Hematology 6 5 Relationship between neurologic deficit severity and final functional outcome shifts and strengthens during first hours after onset. Stroke Hospital Doctor/Hospitalists 5 4 Internal Medicine 5 4 A Novel Computerized Fading Memory Algorithm for Glycemic Control in Postoperative Surgical Patients. Anesth Analg Internal Medicine 5 6 Hypertensive disorders in pregnancy and subsequent diabetes mellitus: a retrospective cohort study. Am J Med Endocrine 6 6 GP/FP/Obstetrics 6 5 Alternative Smoking Cessation Aids: A Meta-analysis of Randomized Controlled Trials. Am J Med General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Respirology/Pulmonology 6 5 Efficacy and Safety of the Once-Daily GLP-1 Receptor Agonist Lixisenatide in Monotherapy: A randomized, double-blind, placebo-controlled trial in patients with type 2 diabetes (GetGoal-Mono). Diabetes Care Endocrine 5 6 Impact of Lifestyle Intervention and Metformin on Health-Related Quality of Life: the Diabetes Prevention Program Randomized Trial. J Gen Intern Med Endocrine 7 6 Citicoline in the treatment of acute ischaemic stroke: an international, randomised, multicentre, placebo-controlled study (ICTUS trial). Lancet Hematology/Thrombosis 4 4 Dual-Mode Weaning Strategy for Difficult-Weaning Tracheotomy Patients: A Feasibility Study. Anesth Analg Intensivist/Critical Care 6 6 Respirology/Pulmonology 5 4 Anesthesiology 5 4 Effect of Telephone-Administered vs Face-to-face Cognitive Behavioral Therapy on Adherence to Therapy and Depression Outcomes Among Primary Care Patients: A Randomized Trial. Telephone vs In-Person Therapy for Depression. JAMA General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6 Psychiatry 5 5 Diagnostic accuracy of magnetic resonance imaging and magnetic resonance arthrography for triangular fibrocartilaginous complex injury: a systematic review and meta-analysis. J Bone Joint Surg Am Surgery - Orthopaedics 6 5
Article Title Discipline Rele- vance News- worthiness Imager evaluation of diabetic retinopathy at the time of imaging in a telemedicine program. Diabetes Care Surgery - Ophthalmology 6 5 Cognitive and graded activity training can alleviate persistent fatigue after stroke: a randomized, controlled trial. Stroke Neurology 5 4 Pharmacologic prophylaxis for acute mountain sickness: a systematic shortcut review. Ann Emerg Med Emergency Medicine 6 5 Ketamine-propofol combination (ketofol) versus propofol alone for emergency department procedural sedation and analgesia: a randomized double-blind trial. Ann Emerg Med Pediatric Emergency Medicine 5 5 Clinical benefits of oral nutritional supplementation for elderly hip fracture patients: a single blind randomised controlled trial. Age Ageing Geriatrics 6 6 Hospital Doctor/Hospitalists 6 5 Internal Medicine 6 5 Surgery - Orthopaedics 5 5 Acupuncture for treatment of irritable bowel syndrome. Cochrane Database Syst Rev Gastroenterology 5 4 General Practice(GP)/Family Practice(FP) 4 5 General Internal Medicine-Primary Care(US) 4 5 The effect of folic acid based homocysteine lowering on cardiovascular events in people with kidney disease: systematic review and meta-analysis. BMJ Nephrology 6 4 Cardiology 5 5 Effect of empirical treatment with moxifloxacin and meropenem vs meropenem on sepsis-related organ dysfunction in patients with severe sepsis: a randomized trial. JAMA Intensivist/Critical Care 6 6 Infectious Disease 6 4 Efficacy and safety of dexamethasone ointment on recurrent aphthous ulceration. Am J Med General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Low-dose Aspirin and Cancer Mortality: A Meta-analysis of Randomized Trials. Am J Med Oncology - General 6 5 General Practice(GP)/Family Practice(FP) 6 4 General Internal Medicine-Primary Care(US) 6 4 Endoscopic ultrasound-guided transmural and percutaneous transhepatic gallbladder drainage are comparable for acute cholecystitis. Gastroenterology Gastroenterology 6 6 Adalimumab induces and maintains mucosal healing in patients with Crohn`s disease: data from the EXTEND trial. Gastroenterology Gastroenterology 6 5 Comparison of existing clinical scoring systems to predict persistent organ failure in patients with acute pancreatitis. Gastroenterology Emergency Medicine 5 5 Hospital Doctor/Hospitalists 5 4 Internal Medicine 5 4 Gastroenterology 5 4
Article Title Discipline Rele- vance News- worthiness Immunohistochemical Double-Hit Score Is a Strong Predictor of Outcome in Patients With Diffuse Large B-Cell Lymphoma Treated With Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone. J Clin Oncol Oncology - Hematology 6 5 Crisis intervention for people with severe mental illnesses. Cochrane Database Syst Rev Psychiatry 6 6 Predicting the Risk of Symptomatic Intracerebral Hemorrhage in Ischemic Stroke Treated With Intravenous Alteplase: Safe Implementation of Treatments in Stroke (SITS) Symptomatic Intracerebral Hemorrhage Risk Score. Stroke Hospital Doctor/Hospitalists 6 6 Internal Medicine 6 6 Diagnostic Accuracy of Pulmonary Embolism Rule-Out Criteria: A Systematic Review and Meta-analysis. Ann Emerg Med Hematology/Thrombosis 6 5 Intensive multifactorial intervention improves modelled coronary heart disease risk in screen-detected Type 2 diabetes mellitus: a cluster randomized controlled trial. Diabet Med Internal Medicine 6 4 Swallowing screens after acute stroke: a systematic review. Stroke Neurology 6 4 Exenatide twice daily versus glimepiride for prevention of glycaemic deterioration in patients with type 2 diabetes with metformin failure (EUREXA): an open-label, randomised controlled trial. Lancet General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6 Endocrine 5 5 Wound Healing after Open Appendectomies in Adult Patients: A Prospective, Randomised Trial Comparing Two Methods of Wound Closure. World J Surg Surgery - General 6 4 Reduced or modified dietary fat for preventing cardiovascular disease. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 7 4 General Internal Medicine-Primary Care(US) 7 4 Cardiology 6 5 Removal of nail polish and finger rings to prevent surgical infection. Cochrane Database Syst Rev Surgery - General 5 5 Surgery - Oncology 5 5 Surgery - Thoracic 4 3 Support for healthy breastfeeding mothers with healthy term babies. Cochrane Database Syst Rev Pediatrics (General) 6 4 Treatment for avascular necrosis of bone in people with sickle cell disease. Cochrane Database Syst Rev Surgery - Orthopaedics 5 5 Physical Medicine and Rehabilitation 5 3 Prophylactic platelet transfusion for prevention of bleeding in patients with haematological disorders after chemotherapy and stem cell transplantation. Cochrane Database Syst Rev Hematology/Thrombosis 6 5 Postoperative Analgesic and Behavioral Effects of Intranasal Fentanyl, Intravenous Morphine, and Intramuscular Morphine in Pediatric Patients Undergoing Bilateral Myringotomy and Placement of Ventilating Tubes. Anesth Analg Pediatrics (General) 6 6 Ursodeoxycholic acid versus placebo, and early term delivery versus expectant management, in women with intrahepatic cholestasis of pregnancy: semifactorial randomised clinical trial. BMJ Obstetrics 5 5 A Prospective, Randomized Study of Cross-Linked and Non-Cross-Linked Polyethylene for Total Hip Arthroplasty at 10-Year Follow-Up. J Arthroplasty Surgery - Orthopaedics 6 4
Article Title Discipline Rele- vance News- worthiness Inhaled versus systemic corticosteroids for the treatment of chronic lung disease in ventilated very low birth weight preterm infants. Cochrane Database Syst Rev Pediatric Neonatology 5 4 Increased risks of parkinsonism in the 3 years after chronic renal failure. Int J Clin Pract Nephrology 5 5 Neurology 4 3 Efficacy and safety of taspoglutide monotherapy in drug-naive type 2 diabetic patients after 24 weeks of treatment: results of a randomized, double-blind, placebo-controlled phase 3 study (T-emerge 1). Diabetes Care General Practice(GP)/Family Practice(FP) 4 4 General Internal Medicine-Primary Care(US) 4 4 Facilitated physical activity as a treatment for depressed adults: randomised controlled trial. BMJ Psychiatry 6 6 Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation. Cochrane Database Syst Rev Hospital Doctor/Hospitalists 6 5 Internal Medicine 6 5 Physical training for asthma. Cochrane Database Syst Rev Internal Medicine 6 4 Validation of two age dependent D-dimer cut-off values for exclusion of deep vein thrombosis in suspected elderly patients in primary care: retrospective, cross sectional, diagnostic analysis. BMJ Hospital Doctor/Hospitalists 6 6 Internal Medicine 6 6 Effectiveness of quality improvement strategies on the management of diabetes: a systematic review and meta-analysis. Lancet Internal Medicine 6 6 Effect of a multifaceted intervention on use of evidence-based therapies in patients with acute coronary syndromes in Brazil: the BRIDGE-ACS randomized trial. JAMA Internal Medicine 6 5 General Practice(GP)/Family Practice(FP) 5 4 General Internal Medicine-Primary Care(US) 5 4
Article Title Discipline Rele- vance News- worthiness Inhibiting the hedgehog pathway in patients with the Basal-cell nevus syndrome. N Engl J Med Dermatology 7 6 Delamanid for Multidrug-Resistant Pulmonary Tuberculosis. N Engl J Med Respirology/Pulmonology 5 6 Validation of DN4 as a screening tool for neuropathic pain in painful diabetic polyneuropathy. Diabet Med Endocrine 5 5 An efficient way to detect poststroke depression by subsequent administration of a 9-item and a 2-item Patient Health Questionnaire. Stroke Hospital Doctor/Hospitalists 5 5 Internal Medicine 5 5 Valid items for screening dysphagia risk in patients with stroke: a systematic review. Stroke Neurology 5 5 Hospital Doctor/Hospitalists 5 4 Internal Medicine 5 4 Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. Cochrane Database Syst Rev Endocrine 5 4 S100-B protein as a screening tool for the early assessment of minor head injury. Ann Emerg Med Pediatric Emergency Medicine 7 7 Emergency Medicine 6 6
Article Title Discipline Rele- vance News- worthiness Autologous stem cell therapy in the treatment of limb ischaemia induced chronic tissue ulcers of diabetic foot patients. Int J Clin Pract Endocrine 5 6 Clinical decision support systems in the care of inpatients with diabetes in non-critical care setting: systematic review. Diabet Med Endocrine 5 5 Randomized trial of clazosentan in patients with aneurysmal subarachnoid hemorrhage undergoing endovascular coiling. Stroke Neurology 4 4 Intracranial Hemorrhage in Atrial Fibrillation Patients During Anticoagulation With Warfarin or Dabigatran: The RE-LY Trial. Stroke Hematology/Thrombosis 6 6 Neurology 6 6 Who may have durable benefit from robotic gait training?: a 2-year follow-up randomized controlled trial in patients with subacute stroke. Stroke Physical Medicine and Rehabilitation 6 5 Neurology 5 5
Article Title Discipline Rele- vance News- worthiness Neoadjuvant Chemotherapy With Methotrexate, Cisplatin, and Doxorubicin With or Without Ifosfamide in Nonmetastatic Osteosarcoma of the Extremity: An Italian Sarcoma Group Trial ISG/OS-1. J Clin Oncol Oncology - General 6 6 Position in the second stage of labour for women without epidural anaesthesia. Cochrane Database Syst Rev GP/FP/Obstetrics 6 5 Pharmacologic treatment for urgency-predominant urinary incontinence in women diagnosed using a simplified algorithm: a randomized trial. Am J Obstet Gynecol General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Integrating an Automated Diabetes Management System into the family management of children with type 1 diabetes: results from a 12-month randomized controlled technology trial. Diabetes Care Pediatrics (General) 6 7 Effects of prenatal micronutrient and early food supplementation on maternal hemoglobin, birth weight, and infant mortality among children in Bangladesh: the MINIMat randomized trial. JAMA Obstetrics 5 5 Cardiopulmonary interventions to decrease blood loss and blood transfusion requirements for liver resection. Cochrane Database Syst Rev Surgery - Gastrointestinal 6 4 Metabolic effects of aerobic training and resistance training in type 2 diabetic subjects: a randomized controlled trial (the RAED2 study). Diabetes Care General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Improved health status with insulin degludec compared with insulin glargine in people with Type 1 diabetes. Diabet Med Endocrine 4 4 Dual or mono antiplatelet therapy for patients with acute ischemic stroke or transient ischemic attack: systematic review and meta-analysis of randomized controlled trials. Stroke General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6 Hospital Doctor/Hospitalists 6 5 Internal Medicine 6 5 Sublingual buprenorphine in acute pain management: a double-blind randomized clinical trial. Ann Emerg Med Emergency Medicine 6 6
Article Title Discipline Rele- vance News- worthiness Adjuvant Therapy in the Treatment of Biliary Tract Cancer: A Systematic Review and Meta-Analysis. J Clin Oncol Oncology - Gastrointestinal 5 5 Intra-abdominal Irrigation at Cesarean Delivery: A Randomized Controlled Trial. Obstet Gynecol Obstetrics 7 6 Barthel Index-Enhanced Feedback for Effective Cardiac Treatment (BI-EFFECT) Study: contribution of the Barthel Index to the Heart Failure Risk Scoring System model in elderly adults with acute heart failure in the emergency department. J Am Geriatr Soc Emergency Medicine 6 5 Chromosome-selective sequencing of maternal plasma cell-free DNA for first-trimester detection of trisomy 21 and trisomy 18. Am J Obstet Gynecol Genetics 6 6 Obstetrics 6 5 Does route of delivery affect maternal and perinatal outcome in women with eclampsia? A randomized controlled pilot study. Am J Obstet Gynecol Obstetrics 7 6
Discipline Rele- vance News- worthiness Heart failure and dysrhythmias after maternal placental syndromes: HAD MPS Study. Heart Obstetrics 6 5 Prednisone, azathioprine, and N-acetylcysteine for pulmonary fibrosis. N Engl J Med Respirology/Pulmonology 7 6 Preoperative chemoradiotherapy for esophageal or junctional cancer. N Engl J Med Surgery - Oncology 7 5 Systematic review of the cost-effectiveness of varenicline vs. bupropion for smoking cessation. Int J Clin Pract General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6 Neurodevelopment after prenatal diagnosis of isolated agenesis of the corpus callosum: an integrative review. Am J Obstet Gynecol Pediatric Neonatology 7 5 Pediatrics (General) 5 4 Randomized Study of Two Chemotherapy Regimens for Treatment of Low-Grade Glioma in Young Children: A Report From the Children`s Oncology Group. J Clin Oncol Oncology - Pediatric 6 6 Randomized Comparison of Intensified Six-Drug Versus Standard Three-Drug Chemotherapy for High-Risk Nonmetastatic Rhabdomyosarcoma and Other Chemotherapy-Sensitive Childhood Soft Tissue Sarcomas: Long-Term Results From the International Society of Pediatric Oncology MMT95 Study. J Clin Oncol Oncology - General 5 5 A comparison of various risk screening methods in predicting discharge from opioid treatment. Clin J Pain Special Interest - Pain -- Physician 7 6 General Practice(GP)/Family Practice(FP) 4 3 General Internal Medicine-Primary Care(US) 4 3
Article Title Discipline Rele- vance News- worthiness Lenalidomide maintenance after stem-cell transplantation for multiple myeloma. N Engl J Med Oncology - Hematology 6 5 Characterizing and identifying risk for falls in the LEAPS study: a randomized clinical trial of interventions to improve walking poststroke. Stroke Neurology 6 5 Can ballooning of the levator hiatus be determined clinically?. Am J Obstet Gynecol Gynecology 5 4 Myocardial oxygenation in coronary artery disease: insights from blood oxygen level-dependent magnetic resonance imaging at 3 tesla. J Am Coll Cardiol Cardiology 5 4 New therapies for chronic hepatitis C infection: a systematic review of evidence from clinical trials. Int J Clin Pract Gastroenterology 6 5 Infectious Disease 6 3 Neonatal morbidity after induction vs expectant monitoring in intrauterine growth restriction at term: a subanalysis of the DIGITAT RCT. Am J Obstet Gynecol Obstetrics 6 5 Ambulatory systolic-diastolic pressure regression index as a predictor of clinical events: a meta-analysis of longitudinal studies. Stroke General Practice(GP)/Family Practice(FP) 5 6 General Internal Medicine-Primary Care(US) 5 6 Cardiology 4 4 Prediction of heart failure mortality in emergent care: a cohort study. Ann Intern Med Hospital Doctor/Hospitalists 7 6 Internal Medicine 7 6
Article Title Discipline Rele- vance News- worthiness Abdominal lift for laparoscopic cholecystectomy. Cochrane Database Syst Rev Surgery - General 5 4 Cephalic version by moxibustion for breech presentation. Cochrane Database Syst Rev Obstetrics 6 4 Magnesium for aneurysmal subarachnoid haemorrhage (MASH-2): a randomised placebo-controlled trial. Lancet Neurology 5 6 Hospital Doctor/Hospitalists 5 5 Internal Medicine 5 5 Preservation Versus Division of Ilioinguinal Nerve on Open Mesh Repair of Inguinal Hernia: A Meta-analysis of Randomized Controlled Trials. World J Surg Surgery - General 6 4 Health-promoting interventions for persons aged 80 and older are successful in the short term--results from the randomized and three-armed Elderly Persons in the Risk Zone study. J Am Geriatr Soc Geriatrics 7 5 The Efficacy of Cap-Assisted Colonoscopy in Polyp Detection and Cecal Intubation: A Meta-Analysis of Randomized Controlled Trials. Am J Gastroenterol Gastroenterology 6 5 Improved Survival with MEK Inhibition in BRAF-Mutated Melanoma. N Engl J Med Dermatology 6 7 Is Femoral Nerve Block Necessary During Total Knee Arthroplasty?: A Randomized Controlled Trial. J Arthroplasty Surgery - Orthopaedics 5 4
Article Title Discipline Rele- vance News- worthiness Early administration of inhaled corticosteroids for preventing chronic lung disease in ventilated very low birth weight preterm neonates. Cochrane Database Syst Rev Pediatric Neonatology 7 5 Prevention of preterm delivery after successful tocolysis in preterm labor by 17 alpha-hydroxyprogesterone caproate: a randomized controlled trial. Am J Obstet Gynecol Obstetrics 4 4 Postpartum Health Promotion Interventions: A Systematic Review. Nurs Res General Practice(GP)/Family Practice(FP) 6 3 Obstetrics 5 5 Specialised treatment based on cognitive behaviour therapy versus usual care for tinnitus: a randomised controlled trial. Lancet Surgery - Ear Nose Throat 5 5 General Practice(GP)/Family Practice(FP) 5 4 General Internal Medicine-Primary Care(US) 5 4 Treatment of Maladaptive Aggression in Youth: CERT Guidelines I. Engagement, Assessment, and Management. Pediatrics Psychiatry 7 5 Pediatrics (General) 6 6 Mortality and Neonatal Morbidity Among Infants 501 to 1500 Grams From 2000 to 2009. Pediatrics Pediatric Hospital Medicine 5 5 A randomized clinical trial to assess the efficacy and safety of real-time continuous glucose monitoring in the management of type 1 diabetes in young children aged 4 to 10 years. Diabetes Care General Practice(GP)/Family Practice(FP) 5 6 Pacemaker Therapy in Patients With Neurally Mediated Syncope and Documented Asystole: Third International Study on Syncope of Uncertain Etiology (ISSUE-3): A Randomized Trial. Circulation Cardiology 6 6 Evaluating the cost-effectiveness of reduced mild hypoglycaemia in subjects with Type 1 diabetes treated with insulin detemir or NPH insulin in Denmark, Sweden, Finland and the Netherlands. Diabet Med Pediatrics (General) 5 5 Endocrine 5 4 Zinc as adjunct treatment in infants aged between 7 and 120 days with probable serious bacterial infection: a randomised, double-blind, placebo-controlled trial. Lancet Pediatrics (General) 6 6 Pediatric Neonatology 6 6 Cost-utility analysis of liraglutide compared with sulphonylurea or sitagliptin, all as add-on to metformin monotherapy in Type 2 diabetes mellitus. Diabet Med General Practice(GP)/Family Practice(FP) 5 6 General Internal Medicine-Primary Care(US) 5 6 Nonpharmacological approaches to the management of chronic pain in community-dwelling older adults: a review of empirical evidence. J Am Geriatr Soc Special Interest - Pain -- Physician 6 4 Multicenter, Double-Blind, Placebo-Controlled, Randomized Phase II Trial of Gemcitabine/Cisplatin Plus Bevacizumab or Placebo in Patients With Malignant Mesothelioma. J Clin Oncol Oncology - Lung 5 5 Role of CHADS(2) Score in Evaluation of Thromboembolic Risk and Mortality in Patients With Atrial Fibrillation Undergoing Direct Current Cardioversion (from the ACUTE Trial Substudy). Am J Cardiol Cardiology 5 4
Article Title Discipline Rele- vance News- worthiness Immediate versus delayed medical treatment for first-trimester miscarriage: a randomized trial. Am J Obstet Gynecol Gynecology 5 4 Efficacy and safety of exenatide once weekly versus metformin, pioglitazone, and sitagliptin used as monotherapy in drug-naive patients with type 2 diabetes (DURATION-4): a 26-week double-blind study. Diabetes Care Endocrine 5 6 Childhood Outcomes after Hypothermia for Neonatal Encephalopathy. N Engl J Med Pediatrics (General) 7 6 Pediatric Neonatology 6 6 Is FENO50 useful diagnostic tool in suspected asthma?. Int J Clin Pract Internal Medicine 6 6 Allergy and Immunology 6 5 Effect of teriparatide on bone mineral density and fracture in postmenopausal osteoporosis: meta-analysis of randomised controlled trials. Int J Clin Pract General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Endocrine 6 5 Comparison of clinical efficacy and safety between denosumab and alendronate in postmenopausal women with osteoporosis: a meta-analysis. Int J Clin Pract Endocrine 6 6 Diagnostic accuracy of exercise stress testing for coronary artery disease: a systematic review and meta-analysis of prospective studies. Int J Clin Pract Internal Medicine 6 4 Long-term effects of three multicomponent exercise interventions on physical performance and fall-related psychological outcomes in community-dwelling older adults: a randomized controlled trial. J Am Geriatr Soc Geriatrics 6 5 General Practice(GP)/Family Practice(FP) 5 3 General Internal Medicine-Primary Care(US) 5 3 Effects of intervention using a community-based walking program for prevention of mental decline: a randomized controlled trial. J Am Geriatr Soc Psychiatry 6 4 General Practice(GP)/Family Practice(FP) 5 4 General Internal Medicine-Primary Care(US) 5 4
Article Title Discipline Rele- vance News- worthiness Identification of a Poor-Prognosis BRAF-Mutant-Like Population of Patients With Colon Cancer. J Clin Oncol Oncology - Gastrointestinal 6 6 Home-based therapy programmes for upper limb functional recovery following stroke. Cochrane Database Syst Rev Physical Medicine and Rehabilitation 4 4 A Validated Prediction Tool for Initial Survivors of In-Hospital Cardiac ArrestPrediction Tool for In-Hospital Cardiac Arrest. Arch Intern Med Neurology 5 4 Interventions for non-oliguric hyperkalaemia in preterm neonates. Cochrane Database Syst Rev Pediatric Neonatology 6 5 Untreated clinical course of cerebral cavernous malformations: a prospective, population-based cohort study. Lancet Neurol Neurology 6 6 Quantifying the effect of metformin treatment and dose on glycemic control. Diabetes Care Endocrine 6 5 Cerebrolysin in patients with acute ischemic stroke in Asia: results of a double-blind, placebo-controlled randomized trial. Stroke Emergency Medicine 7 6 Neurology 5 5 Relation Among the Plasma Triglyceride/High-Density Lipoprotein Cholesterol Concentration Ratio, Insulin Resistance, and Associated Cardio-Metabolic Risk Factors in Men and Women. Am J Cardiol Cardiology 5 5 Moxifloxacin monotherapy for treatment of complicated intra-abdominal infections: a meta-analysis of randomised controlled trials. Int J Clin Pract Hospital Doctor/Hospitalists 5 4 Internal Medicine 5 4 Lumbar drainage of cerebrospinal fluid after aneurysmal subarachnoid hemorrhage: a prospective, randomized, controlled trial (LUMAS). Stroke Surgery - Neurosurgery 7 6
Article Title Discipline Rele- vance News- worthiness Aripiprazole for autism spectrum disorders (ASD). Cochrane Database Syst Rev GP/FP/Mental Health 6 5 Medical interventions for the prevention of platinum-induced hearing loss in children with cancer. Cochrane Database Syst Rev Oncology - Hematology 6 5 Oncology - Pediatric 5 4 Usefulness of Risk Scores to Estimate the Risk of Cardiovascular Disease in Patients With Rheumatoid Arthritis. Am J Cardiol Cardiology 6 6 General Practice(GP)/Family Practice(FP) 5 4 General Internal Medicine-Primary Care(US) 5 4
Article Title Discipline Rele- vance News- worthiness Daclizumab for relapsing remitting multiple sclerosis. Cochrane Database Syst Rev Neurology 6 6 Chinese herbal medicines for threatened miscarriage. Cochrane Database Syst Rev GP/FP/Obstetrics 6 5 Obstetrics 5 3 Intravenous Lornoxicam Is More Effective than Paracetamol as a Supplemental Analgesic After Lower Abdominal Surgery: A Randomized Controlled Trial. World J Surg Surgery - General 6 5 Surgery - Gastrointestinal 5 3 Effect of Coenzyme Q10 Supplementation on Statin-Induced Myalgias. Am J Cardiol Cardiology 6 5 General Practice(GP)/Family Practice(FP) 4 3 General Internal Medicine-Primary Care(US) 4 3 Intervention to Improve Adherence to Lipid-Lowering Medication and Lipid-Levels in Patients With an Increased Cardiovascular Risk. Am J Cardiol General Practice(GP)/Family Practice(FP) 6 3 General Internal Medicine-Primary Care(US) 6 3 Cardiology 5 5 Oral traditional Chinese medication for adhesive small bowel obstruction. Cochrane Database Syst Rev Gastroenterology 5 4 Hospital Doctor/Hospitalists 3 3 Internal Medicine 3 3 Kinesio Taping reduces disability and pain slightly in chronic non-specific low back pain: a randomised trial. J Physiother General Practice(GP)/Family Practice(FP) 5 4 General Internal Medicine-Primary Care(US) 5 4 NGX-4010, a capsaicin 8% dermal patch, administered alone or in combination with systemic neuropathic pain medications, reduces pain in patients with postherpetic neuralgia. Clin J Pain General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5
Article Title Discipline Rele- vance News- worthiness Mortality and morbidity in preterm small-for-gestational-age infants: a population-based study. Am J Obstet Gynecol Pediatric Neonatology 6 5 Effect of Exercise on Blood Pressure in Type 2 Diabetes: A Randomized Controlled Trial. J Gen Intern Med General Practice(GP)/Family Practice(FP) 6 4 General Internal Medicine-Primary Care(US) 6 4 Endocrine 4 4 Effect of Triclosan-Coated Sutures on the Incidence of Surgical Wound Infection After Lower Limb Revascularization Surgery: A Randomized Controlled Trial. World J Surg Surgery - Vascular 6 4 Meta-analysis of Long-Chain Polyunsaturated Fatty Acid Supplementation of Formula and Infant Cognition. Pediatrics Pediatrics (General) 5 5 Capnographic Monitoring Reduces the Incidence of Arterial Oxygen Desaturation and Hypoxemia During Propofol Sedation for Colonoscopy: A Randomized, Controlled Study (ColoCap Study). Am J Gastroenterol Anesthesiology 7 5 Apixaban versus aspirin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a predefined subgroup analysis from AVERROES, a randomised trial. Lancet Neurol Cardiology 7 6 General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Effectiveness of a multidimensional physical therapy program on pain, pressure hypersensitivity, and trigger points in breast cancer survivors: a randomized controlled clinical trial. Clin J Pain Oncology - Breast 4 4 Symptomatic treatment of the cough in whooping cough. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 6 5 Pediatrics (General) 6 5 Pediatric Hospital Medicine 6 5
Article Title Discipline Rele- vance News- worthiness Granulocyte-colony stimulating factor for mobilizing bone marrow stem cells in subacute stroke: the stem cell trial of recovery enhancement after stroke 2 randomized controlled trial. Stroke Neurology 5 5 Prediction of outcome after moderate and severe traumatic brain injury: External validation of the International Mission on Prognosis and Analysis of Clinical Trials (IMPACT) and Corticoid Randomisation After Significant Head injury (CRASH) prognostic models. Crit Care Med Intensivist/Critical Care 5 6 Repeat antenatal glucocorticoids for women at risk of preterm birth: a Cochrane Systematic Review. Am J Obstet Gynecol Pediatrics (General) 6 5 The 5-tier system of assessing fetal heart rate tracings is superior to the 3-tier system in identifying fetal acidemia. Am J Obstet Gynecol Obstetrics 6 6 Pediatric Neonatology 5 5 Pulsatile versus continuous administration of oxytocin for induction and augmentation of labor: two randomized controlled trials. Am J Obstet Gynecol Obstetrics 6 6 Risk Assessment Tool for Distant Recurrence After Platinum-Based Concurrent Chemoradiation in Patients With Locally Advanced Cervical Cancer: A Korean Gynecologic Oncology Group Study. J Clin Oncol Oncology - Gynecology 5 6 Treatment of Maladaptive Aggression in Youth: CERT Guidelines II. Treatments and Ongoing Management. Pediatrics Psychiatry 7 5 Menopausal Hormone Therapy for the Primary Prevention of Chronic Conditions: A Systematic Review to Update the U.S. Preventive Services Task Force Recommendations. Ann Intern Med General Practice(GP)/Family Practice(FP) 7 6 General Internal Medicine-Primary Care(US) 7 6 Internal Medicine 6 5 Gynecology 6 5 Role of Intensive Glucose Control in Development of Renal End Points in Type 2 Diabetes Mellitus: Systematic Review and Meta-analysis. Arch Intern Med General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Benefits and safety of long-term fenofibrate therapy in people with type 2 diabetes and renal impairment: the FIELD Study. Diabetes Care General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 Internal Medicine 5 5 Cardiology 3 4 Aspirin for preventing the recurrence of venous thromboembolism. N Engl J Med General Practice(GP)/Family Practice(FP) 7 7 General Internal Medicine-Primary Care(US) 7 7
Article Title Discipline Rele- vance News- worthiness Combination Chemotherapy in Advanced Adrenocortical Carcinoma. N Engl J Med Oncology - General 5 5 Phase III Trial of Cetuximab With Continuous or Intermittent Fluorouracil, Leucovorin, and Oxaliplatin (Nordic FLOX) Versus FLOX Alone in First-Line Treatment of Metastatic Colorectal Cancer: The NORDIC-VII Study. J Clin Oncol Oncology - Gastrointestinal 6 6 Comparison of A Priori Versus Provisional Heparin Therapy on Radial Artery Occlusion After Transradial Coronary Angiography and Patent Hemostasis (from the PHARAOH Study). Am J Cardiol Surgery - Vascular 5 4 Oxytocin augmentation of labour in women with epidural analgesia for reducing operative deliveries. Cochrane Database Syst Rev Anesthesiology 7 6 Spiritual and religious interventions for well-being of adults in the terminal phase of disease. Cochrane Database Syst Rev Geriatrics 6 5 Inhaled versus systemic corticosteroids for preventing chronic lung disease in ventilated very low birth weight preterm neonates. Cochrane Database Syst Rev Pediatric Neonatology 6 4 Betamethasone dosing interval: 12 or 24 hours apart? A randomized, noninferiority open trial. Am J Obstet Gynecol Obstetrics 6 6 Efficacy of treatments for orthostatic hypotension: a systematic review. Age Ageing Cardiology 5 5 Hip fracture management: tailoring care for the older patient. JAMA Geriatrics 7 6 Surgery - Orthopaedics 6 4 Balance training reduces fear of falling and improves dynamic balance and isometric strength in institutionalised older people: a randomised trial. J Physiother Physical Medicine and Rehabilitation 5 5 The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial ): a randomised controlled trial. Lancet Hospital Doctor/Hospitalists 6 6 Internal Medicine 6 6 Drotrecogin Alfa (Activated) in Adults with Septic Shock. N Engl J Med Intensivist/Critical Care 6 6 Hospital Doctor/Hospitalists 5 4 Internal Medicine 5 4 Rapid Point-of-Care First-Line Screening Tests for Hepatitis B Infection: A Meta-Analysis of Diagnostic Accuracy (1980-2010). Am J Gastroenterol Infectious Disease 6 5
Article Title Discipline Rele- vance News- worthiness A statewide trial of the SafeCare home-based services model with parents in Child Protective Services. Pediatrics Psychiatry 6 6 Interventions to improve the appropriate use of polypharmacy for older people. Cochrane Database Syst Rev Geriatrics 6 4 Knee length versus thigh length graduated compression stockings for prevention of deep vein thrombosis in postoperative surgical patients. Cochrane Database Syst Rev Hospital Doctor/Hospitalists 6 4 Internal Medicine 6 4 No effect of the FitFor2 exercise programme on blood glucose, insulin sensitivity, and birthweight in pregnant women who were overweight and at risk for gestational diabetes: results of a randomised controlled trial. BJOG General Practice(GP)/Family Practice(FP) 5 4 Derivation and validation of updated QFracture algorithm to predict risk of osteoporotic fracture in primary care in the United Kingdom: prospective open cohort study. BMJ General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Geriatrics 5 6 Meta-Analysis of Cardiovascular Outcomes With Dronedarone in Patients With Atrial Fibrillation or Heart Failure. Am J Cardiol Hospital Doctor/Hospitalists 6 6 Internal Medicine 6 6 Rapid viral diagnosis for acute febrile respiratory illness in children in the Emergency Department. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 6 6 Leukotriene receptor antagonists in addition to usual care for acute asthma in adults and children. Cochrane Database Syst Rev Pediatrics (General) 6 5 Prediction of New Onset Atrial Fibrillation After Cardiac Revascularization Surgery. Am J Cardiol Surgery - Cardiac 5 4 Meta-Analysis of Randomized Trials of Angioedema as an Adverse Event of Renin-Angiotensin System Inhibitors. Am J Cardiol Internal Medicine 6 5 Cardiology 5 4 Performance of the Seattle Heart Failure Model in Implantable Defibrillator Patients Treated With Cardiac Resynchronization Therapy. Am J Cardiol Surgery - Cardiac 5 5 Effect of a guideline-based multicomponent intervention on use of physical restraints in nursing homes: a randomized controlled trial. JAMA Geriatrics 5 4 General Practice(GP)/Family Practice(FP) 4 3 General Internal Medicine-Primary Care(US) 4 3 Effect of continuous positive airway pressure on the incidence of hypertension and cardiovascular events in nonsleepy patients with obstructive sleep apnea: a randomized controlled trial. JAMA General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6 Cardiology 4 5
Article Title Discipline Rele- vance News- worthiness Chlamydia trachomatis Antigens Recognized in Women With Tubal Factor Infertility, Normal Fertility, and Acute Infection. Obstet Gynecol Gynecology 6 6 Antioxidants and other pharmacological treatments for Friedreich ataxia. Cochrane Database Syst Rev Neurology 6 5 Oral Dimenhydrinate Versus Placebo in Children With Gastroenteritis: A Randomized Controlled Trial. Pediatrics Gastroenterology 6 5 Pediatrics (General) 6 5 Emergency Medicine 5 3 Usefulness of B-type natriuretic peptide and N-terminal pro-B-type natriuretic peptide as biomarkers for heart failure in young children with single ventricle congenital heart disease. Am J Cardiol Cardiology 6 5 Clofarabine Plus Cytarabine Compared With Cytarabine Alone in Older Patients With Relapsed or Refractory Acute Myelogenous Leukemia: Results From the CLASSIC I Trial. J Clin Oncol Oncology - Hematology 6 4 Effects of interventions in pregnancy on maternal weight and obstetric outcomes: meta-analysis of randomised evidence. BMJ Pediatric Neonatology 5 4 Early routine endoscopic retrograde cholangiopancreatography strategy versus early conservative management strategy in acute gallstone pancreatitis. Cochrane Database Syst Rev Surgery - General 6 5 Hypothalamic-pituitary-adrenal (HPA) axis suppression after treatment with glucocorticoid therapy for childhood acute lymphoblastic leukaemia. Cochrane Database Syst Rev Oncology - Hematology 6 5 Randomized trial of automated, electronic monitoring to facilitate early detection of sepsis in the intensive care unit. Crit Care Med Infectious Disease 4 4 Calcium antagonists for acute ischemic stroke. Cochrane Database Syst Rev Hospital Doctor/Hospitalists 6 4 Internal Medicine 6 4 Cognitive-behavioural interventions for children who have been sexually abused. Cochrane Database Syst Rev Pediatrics (General) 5 5 Early skin-to-skin contact for mothers and their healthy newborn infants. Cochrane Database Syst Rev Pediatric Neonatology 6 5
Article Title Discipline Rele- vance News- worthiness Meta-analysis of subclavian insertion and nontunneled central venous catheter-associated infection risk reduction in critically ill adults. Crit Care Med Intensivist/Critical Care 5 5 Treatment for mitochondrial disorders. Cochrane Database Syst Rev Neurology 5 5 Systemic Lidocaine to Improve Postoperative Quality of Recovery After Ambulatory Laparoscopic Surgery. Anesth Analg Anesthesiology 6 5 Gynecology 5 5 Effect of hydroxyethyl starch on bleeding after cardiopulmonary bypass: A meta-analysis of randomized trials. J Thorac Cardiovasc Surg Surgery - Cardiac 4 4 The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials. Lancet General Practice(GP)/Family Practice(FP) 7 5 General Internal Medicine-Primary Care(US) 7 5 Internal Medicine 6 6 Cardiology 6 6 Inspiratory muscle training for the recovery of function after stroke. Cochrane Database Syst Rev Neurology 5 4 Risk score for predicting long-term mortality after coronary artery bypass graft surgery. Circulation Cardiology 6 5 Narrow Band Imaging for Detection of Dysplasia in Colitis: A Randomized Controlled Trial. Am J Gastroenterol Gastroenterology 5 4 Preventing delirium in an acute hospital using a non-pharmacological intervention. Age Ageing Hospital Doctor/Hospitalists 7 5 Internal Medicine 7 5 Effect of an Indwelling Pleural Catheter vs Chest Tube and Talc Pleurodesis for Relieving Dyspnea in Patients With Malignant Pleural Effusion: The TIME2 Randomized Controlled TrialIndwelling Pleural Catheters vs Talc Pleurodesis. JAMA Oncology - Lung 6 6 Natural History Following the First Attack of Acute Pancreatitis. Am J Gastroenterol Gastroenterology 6 5 Interventions for chronic blepharitis. Cochrane Database Syst Rev Surgery - Ophthalmology 6 5 Hypertonic Saline and Acute Wheezing in Preschool Children. Pediatrics Respirology/Pulmonology 6 6 Pediatric Emergency Medicine 6 6 Maintenance treatment with antipsychotic drugs for schizophrenia. Cochrane Database Syst Rev GP/FP/Mental Health 6 4
Article Title Discipline Rele- vance News- worthiness Treatment of rotator cuff tears in older individuals: a systematic review. J Shoulder Elbow Surg Surgery - Orthopaedics 5 4 Randomized Phase II Trial of Sunitinib on an Intermittent Versus Continuous Dosing Schedule As First-Line Therapy for Advanced Renal Cell Carcinoma. J Clin Oncol Oncology - Genitourinary 6 6 Split-Dosed MiraLAX/Gatorade Is an Effective, Safe, and Tolerable Option for Bowel Preparation in Low-Risk Patients: A Randomized Controlled Study. Am J Gastroenterol Gastroenterology 5 5 A double-blind, randomized clinical trial comparing soybean oil-based versus olive oil-based lipid emulsions in adult medical-surgical intensive care unit patients requiring parenteral nutrition. Crit Care Med Intensivist/Critical Care 5 5 Randomized clinical trial of rotating-platform and fixed-bearing total knee arthroplasty: no clinically detectable differences at five years. J Bone Joint Surg Am Surgery - Orthopaedics 6 5 Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet Oncology - General 6 6 Midregional pro-A-type natriuretic peptide for diagnosis and prognosis in patients with suspected acute myocardial infarction. Am J Cardiol Hospital Doctor/Hospitalists 5 4 Internal Medicine 5 4 Healthy steps trial: pedometer-based advice and physical activity for low-active older adults. Ann Fam Med General Practice(GP)/Family Practice(FP) 6 4 General Internal Medicine-Primary Care(US) 6 4 Home uterine monitoring for detecting preterm labour. Cochrane Database Syst Rev Obstetrics 6 5 Inhaled Hypertonic Saline in Infants and Children Younger Than 6 Years With Cystic Fibrosis: The ISIS Randomized Controlled Trial. JAMA Pediatrics (General) 6 6 Comparison of late results of percutaneous coronary intervention among stable patients /==65 versus 65 years of age with an occluded infarct related artery (from the Occluded Artery Trial). Am J Cardiol Hospital Doctor/Hospitalists 5 4 Internal Medicine 5 4 Ultrasound guided corticosteroid injection for plantar fasciitis: randomised controlled trial. BMJ General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6 Rheumatology 5 5 Continuous compared with cyclic oral contraceptives for the treatment of primary dysmenorrhea: a randomized controlled trial. Obstet Gynecol General Practice(GP)/Family Practice(FP) 6 4 General Internal Medicine-Primary Care(US) 6 4
# Article Title 1 Meta-Analysis of Efficacy and Safety of New Oral Anticoagulants (Dabigatran, Rivaroxaban, Apixaban) Versus Warfarin in Patients With Atrial Fibrillation. Am J Cardiol 2 Warfarin and aspirin in patients with heart failure and sinus rhythm. N Engl J Med 3 Angiotensin receptor blockers for heart failure. Cochrane Database Syst Rev 4 Risk of Clostridium difficile Infection With Acid Suppressing Drugs and Antibiotics: Meta-Analysis. Am J Gastroenterol 5 Risk of cardiovascular serious adverse events associated with varenicline use for tobacco cessation: systematic review and meta-analysis. BMJ 6 The usefulness of HbA1c in postpartum reclassification of gestational diabetes. BJOG 7 Dopamine versus norepinephrine in the treatment of septic shock: a meta-analysis*. Crit Care Med 8 Venous thrombosis in users of non-oral hormonal contraception: follow-up study, Denmark 2001-10. BMJ 9 Nicotine receptor partial agonists for smoking cessation. Cochrane Database Syst Rev 10 Long-acting beta(2)-agonist in addition to tiotropium versus either tiotropium or long-acting beta(2)-agonist alone for chronic obstructive pulmonary disease. Cochrane Database Syst Rev
Article Title Discipline Rele- vance News- worthiness Utility of the bladder flap at cesarean delivery: a randomized controlled trial. Obstet Gynecol Obstetrics 6 6 Azithromycin and the risk of cardiovascular death. N Engl J Med General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6 Internal Medicine 6 5 Iron for restless legs syndrome. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6 Brief Motivational Interviewing Intervention for Peer Violence and Alcohol Use in Teens: One-Year Follow-up. Pediatrics GP/FP/Mental Health 6 6 Pediatrics (General) 6 6 Colorectal-Cancer Incidence and Mortality with Screening Flexible Sigmoidoscopy. N Engl J Med General Practice(GP)/Family Practice(FP) 7 5 General Internal Medicine-Primary Care(US) 7 5 Gastroenterology 7 5 Oncology - Gastrointestinal 6 5 Health coaching to improve hypertension treatment in a low-income, minority population. Ann Fam Med General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Benefits and Harms of CT Screening for Lung Cancer: A Systematic Review. JAMA General Practice(GP)/Family Practice(FP) 7 5 General Internal Medicine-Primary Care(US) 7 5 Oncology - General 6 5
Article Title Discipline Rele- vance News- worthiness Sunitinib Plus Erlotinib Versus Placebo Plus Erlotinib in Patients With Previously Treated Advanced Non-Small-Cell Lung Cancer: A Phase III Trial. J Clin Oncol Oncology - Lung 6 5 Superiority of the Triple Combination of Bortezomib-Thalidomide-Dexamethasone Over the Dual Combination of Thalidomide-Dexamethasone in Patients With Multiple Myeloma Progressing or Relapsing After Autologous Transplantation: The MMVAR/IFM 2005-04 Randomized Phase III Trial From the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation. J Clin Oncol Oncology - Hematology 6 5 Meta-Analysis Comparing Bivalirudin Versus Heparin Monotherapy on Ischemic and Bleeding Outcomes After Percutaneous Coronary Intervention. Am J Cardiol Cardiology 6 5 Hematology/Thrombosis 4 4 Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis. BMJ Surgery - General 7 6 Hematology/Thrombosis 5 3
Article Title Discipline Rele- vance News- worthiness Strategies of radioiodine ablation in patients with low-risk thyroid cancer. N Engl J Med Oncology - General 6 6 Surgery - Oncology 6 6 Antipsychotic drugs versus placebo for relapse prevention in schizophrenia: a systematic review and meta-analysis. Lancet Psychiatry 7 5 Late (/= 7 days) inhalation corticosteroids to reduce bronchopulmonary dysplasia in preterm infants. Cochrane Database Syst Rev Pediatric Neonatology 6 5 Comparison of risk prediction using the CKD-EPI equation and the MDRD study equation for estimated glomerular filtration rate. JAMA Nephrology 6 6 Lenalidomide after stem-cell transplantation for multiple myeloma. N Engl J Med Oncology - Hematology 6 6 Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases. Cochrane Database Syst Rev Oncology - General 5 5
Article Title Discipline Rele- vance News- worthiness Usefulness of diastolic time measured on electrocardiogram to improve sensitivity and specificity of exercise tolerance tests. Am J Cardiol Cardiology 5 4 Use of a Disposable Acupressure Device as Part of a Multimodal Antiemetic Strategy for Reducing Postoperative Nausea and Vomiting. Anesth Analg Anesthesiology 5 5 Analysis of prognostic factors for patients with chordoma with use of the California Cancer Registry. J Bone Joint Surg Am Surgery - Neurosurgery 6 6 Bisphosphonates for osteoporosis in people with cystic fibrosis. Cochrane Database Syst Rev Respirology/Pulmonology 6 6 Value of electrocardiogram in the differentiation of hypertensive heart disease, hypertrophic cardiomyopathy, aortic stenosis, amyloidosis, and Fabry disease. Am J Cardiol Cardiology 5 6 Fetal electrocardiogram (ECG) for fetal monitoring during labour. Cochrane Database Syst Rev Obstetrics 6 6 Large-Scale Validation of the Centor and McIsaac Scores to Predict Group A Streptococcal Pharyngitis. Arch Intern Med General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Vitamin D supplementation for cystic fibrosis. Cochrane Database Syst Rev Respirology/Pulmonology 5 5 General Practice(GP)/Family Practice(FP) 4 3 General Internal Medicine-Primary Care(US) 4 3 Heparin or 0.9% sodium chloride to maintain central venous catheter patency: A randomized trial. Crit Care Med Intensivist/Critical Care 6 5 Continuous lenalidomide treatment for newly diagnosed multiple myeloma. N Engl J Med Oncology - Hematology 6 6 OCEANS: A Randomized, Double-Blind, Placebo-Controlled Phase III Trial of Chemotherapy With or Without Bevacizumab in Patients With Platinum-Sensitive Recurrent Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancer. J Clin Oncol Oncology - Gynecology 6 7 Ipilimumab in Combination With Paclitaxel and Carboplatin As First-Line Treatment in Stage IIIB/IV Non-Small-Cell Lung Cancer: Results From a Randomized, Double-Blind, Multicenter Phase II Study. J Clin Oncol Oncology - Lung 5 6 Weekly nab-Paclitaxel in Combination With Carboplatin Versus Solvent-Based Paclitaxel Plus Carboplatin as First-Line Therapy in Patients With Advanced Non-Small-Cell Lung Cancer: Final Results of a Phase III Trial. J Clin Oncol Oncology - Lung 5 5 Developmental Outcome at 6.5 Years After Acidosis in Term Newborns: A Population-Based Study. Pediatrics Pediatrics (General) 7 5 Use of modified ultrafiltration in adults undergoing coronary artery bypass grafting is associated with inflammatory modulation and less postoperative blood loss: A randomized and controlled study. J Thorac Cardiovasc Surg Surgery - General 5 4
Article Title Discipline Rele- vance News- worthiness Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion. Cochrane Database Syst Rev Oncology - Hematology 6 6 Carbetocin for preventing postpartum haemorrhage. Cochrane Database Syst Rev Pediatric Neonatology 4 4 Randomized Trial of Sumatriptan and Naproxen Sodium Combination in Adolescent Migraine. Pediatrics Pediatrics (General) 6 6 Self-Management of Lymphedema: A Systematic Review of the Literature From 2004 to 2011. Nurs Res Oncology - General 5 4 Effectiveness of dementia follow-up care by memory clinics or general practitioners: randomised controlled trial. BMJ Psychiatry 6 6 Geriatrics 6 5 General Practice(GP)/Family Practice(FP) 6 4 General Internal Medicine-Primary Care(US) 6 4
Article Title Discipline Rele- vance News- worthiness Intravenous secretin for autism spectrum disorders (ASD). Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 6 6 Pediatrics (General) 4 4 Steroidal contraceptives: effect on carbohydrate metabolism in women without diabetes mellitus. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 5 4 General Internal Medicine-Primary Care(US) 5 4 Early or Delayed Enteral Feeding for Preterm Growth-Restricted Infants: A Randomized Trial. Pediatrics Pediatrics (General) 6 5 Immunosuppressant and immunomodulatory treatments for multifocal motor neuropathy. Cochrane Database Syst Rev Neurology 4 4 Diagnostic accuracy of laxative-free computed tomographic colonography for detection of adenomatous polyps in asymptomatic adults: a prospective evaluation. Ann Intern Med Gastroenterology 4 4 A multidimensional index and staging system for idiopathic pulmonary fibrosis. Ann Intern Med Respirology/Pulmonology 6 5 Carbon dioxide insufflation in open-chamber cardiac surgery: A double-blind, randomized clinical trial of neurocognitive effects. J Thorac Cardiovasc Surg Cardiology 5 5 Intranasal corticosteroids in management of acute sinusitis: a systematic review and meta-analysis. Ann Fam Med Pediatrics (General) 5 4
Article Title Discipline Rele- vance News- worthiness A multifaceted program for improving quality of care in intensive care units: IATROREF study. Crit Care Med Intensivist/Critical Care 6 5 Interventions for preventing infection in nephrotic syndrome. Cochrane Database Syst Rev Pediatrics (General) 4 4 Critical illness from 2009 pandemic influenza A virus and bacterial coinfection in the United States*. Crit Care Med Infectious Disease 6 5 Intensivist/Critical Care 5 4 Meta-analysis of randomized controlled trials comparing intracoronary and intravenous administration of glycoprotein IIb/IIIa inhibitors in patients with ST-elevation myocardial infarction. Am J Cardiol Cardiology 6 5 Clinical and Economic Evidence for Intravenous Acetaminophen. Pharmacotherapy Internal Medicine 6 4
Article Title Discipline Rele- vance News- worthiness Randomized, Double-Blind, Placebo-Controlled Phase III Trial Comparing Docetaxel and Prednisone With or Without Bevacizumab in Men With Metastatic Castration-Resistant Prostate Cancer: CALGB 90401. J Clin Oncol Oncology - Genitourinary 7 6 Multicenter Randomized Phase II Clinical Trial Comparing Neoadjuvant Oxaliplatin, Capecitabine, and Preoperative Radiotherapy With or Without Cetuximab Followed by Total Mesorectal Excision in Patients With High-Risk Rectal Cancer (EXPERT-C). J Clin Oncol Oncology - Gastrointestinal 6 6 Ablation with low-dose radioiodine and thyrotropin alfa in thyroid cancer. N Engl J Med Oncology - General 7 6 Association of frontal QRS-T angle--age risk score on admission electrocardiogram with mortality in patients admitted with an acute coronary syndrome. Am J Cardiol Cardiology 5 5 Hyperbaric oxygenation for tumour sensitisation to radiotherapy. Cochrane Database Syst Rev Oncology - General 5 5 Randomized Phase III Study Comparing Paclitaxel/Cisplatin/ Gemcitabine and Gemcitabine/Cisplatin in Patients With Locally Advanced or Metastatic Urothelial Cancer Without Prior Systemic Therapy: EORTC Intergroup Study 30987. J Clin Oncol Oncology - Genitourinary 5 4 Effects of circuit training as alternative to usual physiotherapy after stroke: randomised controlled trial. BMJ Neurology 5 5 Induction Chemotherapy and Dose Intensification of the Radiation Boost in Locally Advanced Anal Canal Carcinoma: Final Analysis of the Randomized UNICANCER ACCORD 03 Trial. J Clin Oncol Oncology - Gastrointestinal 5 5 A Comprehensive Care Management Program to Prevent Chronic Obstructive Pulmonary Disease Hospitalizations: A Randomized, Controlled Trial. Ann Intern Med General Practice(GP)/Family Practice(FP) 5 6 General Internal Medicine-Primary Care(US) 5 6 Internal Medicine 5 6
Article Title Discipline Rele- vance News- worthiness Ultrasound-Guided Ilioinguinal/Iliohypogastric Nerve Blocks for Persistent Inguinal Postherniorrhaphy Pain: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial. Anesth Analg Anesthesiology 6 7 Special Interest - Pain -- Physician 3 3 Cognitive behaviour therapy versus other psychosocial treatments for schizophrenia. Cochrane Database Syst Rev Psychiatry 5 6 Paracervical block for pain control in first-trimester surgical abortion: a randomized controlled trial. Obstet Gynecol Obstetrics 6 4 How does number of risk factors affect prognosis in young patients with ischemic stroke?. Stroke General Practice(GP)/Family Practice(FP) 5 6 General Internal Medicine-Primary Care(US) 5 6 Pediatrics (General) 4 5 Interventions for ingrowing toenails. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 5 4 General Internal Medicine-Primary Care(US) 5 4 Surgery - General 5 4 Face washing promotion for preventing active trachoma. Cochrane Database Syst Rev Tropical and Travel Medicine 5 4 General Practice(GP)/Family Practice(FP) 3 3 Total versus subtotal hysterectomy for benign gynaecological conditions. Cochrane Database Syst Rev Gynecology 6 5 Adjuvant radiotherapy for stage I endometrial cancer. Cochrane Database Syst Rev Gynecology 6 5 Hyperbaric oxygen therapy for chronic wounds. Cochrane Database Syst Rev Endocrine 5 5 Internal Medicine 5 3 Cost-effectiveness of a Multicondition Collaborative Care Intervention: A Randomized Controlled Trial. Arch Gen Psychiatry Psychiatry 6 4 Venous thrombosis in users of non-oral hormonal contraception: follow-up study, Denmark 2001-10. BMJ Endocrine 6 6 Interventions for unilateral and bilateral refractive amblyopia. Cochrane Database Syst Rev Surgery - Ophthalmology 7 4 Home care by outreach nursing for chronic obstructive pulmonary disease. Cochrane Database Syst Rev Hospital Doctor/Hospitalists 6 6 Internal Medicine 6 6 Efficacy of cognitive behavioral therapy for anxiety disorders in older people: a meta-analysis and meta-regression of randomized controlled trials. J Am Geriatr Soc Psychiatry 6 5 Nicotine receptor partial agonists for smoking cessation. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6
Article Title Discipline Rele- vance News- worthiness The Novel Histologic International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society Classification System of Lung Adenocarcinoma Is a Stage-Independent Predictor of Survival. J Clin Oncol Oncology - Lung 6 6 Preoperative statin therapy for patients undergoing cardiac surgery. Cochrane Database Syst Rev Cardiology 6 6 Preoperative identification of a low-risk group for lymph node metastasis in endometrial cancer: a korean gynecologic oncology group study. J Clin Oncol Oncology - Gynecology 5 6 Randomized trial comparing late concentration-controlled calcineurin inhibitor or mycophenolate mofetil withdrawal. Transplantation Nephrology 6 6 Once-Daily MMX(R) Mesalamine for Endoscopic Maintenance of Remission of Ulcerative Colitis. Am J Gastroenterol Gastroenterology 6 5 Screening Women for Intimate Partner Violence: A Systematic Review to Update the 2004 U.S. Preventive Services Task Force Recommendation. Ann Intern Med General Practice(GP)/Family Practice(FP) 6 4 General Internal Medicine-Primary Care(US) 6 4 Vitamin D Supplementation and Depression in the Women`s Health Initiative Calcium and Vitamin D Trial. Am J Epidemiol GP/FP/Mental Health 6 4 Prospective randomized study of arthroscopic rotator cuff repair using an early versus delayed postoperative physical therapy protocol. J Shoulder Elbow Surg Physical Medicine and Rehabilitation 5 5
Article Title Discipline Rele- vance News- worthiness Effects of robot-assisted upper limb rehabilitation on daily function and real-world arm activity in patients with chronic stroke: a randomized controlled trial. Clin Rehabil Physical Medicine and Rehabilitation 6 4 Second generation endometrial ablation techniques for heavy menstrual bleeding: network meta-analysis. BMJ Gynecology 5 6 Antitumor Activity and Safety of Tivozanib (AV-951) in a Phase II Randomized Discontinuation Trial in Patients With Renal Cell Carcinoma. J Clin Oncol Oncology - Genitourinary 5 5 Femoral Nerve Block With Selective Tibial Nerve Block Provides Effective Analgesia Without Foot Drop After Total Knee Arthroplasty: A Prospective, Randomized, Observer-Blinded Study. Anesth Analg Anesthesiology 6 5 Long-acting beta(2)-agonist in addition to tiotropium versus either tiotropium or long-acting beta(2)-agonist alone for chronic obstructive pulmonary disease. Cochrane Database Syst Rev Respirology/Pulmonology 6 6 General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Interventions for improving outcomes in patients with multimorbidity in primary care and community settings. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 7 5 General Internal Medicine-Primary Care(US) 7 5 Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial. Lancet Oncology - Gastrointestinal 5 5 Effective analgesia using physical interventions for infant immunizations. Pediatrics Pediatrics (General) 6 6 Single dose oral etoricoxib for acute postoperative pain in adults. Cochrane Database Syst Rev Anesthesiology 6 5 Surgery - Orthopaedics 5 5 A Randomized Trial of Urodynamic Testing before Stress-Incontinence Surgery. N Engl J Med Surgery - Urology 7 7 Corticosteroids for treating optic neuritis. Cochrane Database Syst Rev Surgery - Ophthalmology 6 5 Probiotics for the prevention and treatment of antibiotic-associated diarrhea: a systematic review and meta-analysis. JAMA General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Drug therapies for reducing gastric acidity in people with cystic fibrosis. Cochrane Database Syst Rev Respirology/Pulmonology 4 4 Effects of preoperative aspirin in coronary artery bypass grafting: A double-blind, placebo-controlled, randomized trial. J Thorac Cardiovasc Surg Cardiology 5 4
Article Title Discipline Rele- vance News- worthiness A multicenter randomized trial comparing amphilimus- with paclitaxel-eluting stents in de novo native coronary artery lesions. J Am Coll Cardiol Cardiology 6 4 Revised prognostic staging system for light chain amyloidosis incorporating cardiac biomarkers and serum free light chain measurements. J Clin Oncol Oncology - Hematology 6 5 Risk of Arrhythmia and Sudden Death in Patients with Asymptomatic Pre-Excitation: A Meta Analysis. Circulation Internal Medicine 5 5 Pediatrics (General) 5 4 Interventions for congenital talipes equinovarus (clubfoot). Cochrane Database Syst Rev Surgery - Orthopaedics 6 4 Shouldice technique versus other open techniques for inguinal hernia repair. Cochrane Database Syst Rev Surgery - General 6 4 Primary care based clinics for asthma. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 6 4 General Internal Medicine-Primary Care(US) 6 4 Risk of cardiovascular serious adverse events associated with varenicline use for tobacco cessation: systematic review and meta-analysis. BMJ General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6 Cardiology 5 5 Effect of Antenatal Corticosteroids on Fetal Growth and Gestational Age at Birth. Obstet Gynecol Obstetrics 6 5 Pediatric Neonatology 5 3 Wound Healing and Infection in Surgery: The Clinical Impact of Smoking and Smoking Cessation: A Systematic Review and Meta-analysis. Arch Surg Infectious Disease 5 4
Article Title Discipline Rele- vance News- worthiness Treatment for cramps in amyotrophic lateral sclerosis/motor neuron disease. Cochrane Database Syst Rev Neurology 5 5 Randomized Phase II Trial of Erlotinib With and Without Entinostat in Patients With Advanced Non-Small-Cell Lung Cancer Who Progressed on Prior Chemotherapy. J Clin Oncol Oncology - Lung 6 6 A Clinical Trial to Maintain Glycemic Control in Youth with Type 2 Diabetes. N Engl J Med Pediatrics (General) 7 7 Local anaesthetic nerve block for pain management in labour. Cochrane Database Syst Rev GP/FP/Anesthesia 6 5 GP/FP/Obstetrics 5 3 Effect of Fish Oil Supplementation on Graft Patency and Cardiovascular Events Among Patients With New Synthetic Arteriovenous Hemodialysis Grafts: A Randomized Controlled Trial. JAMA Nephrology 5 6 Single dose oral aspirin for acute postoperative pain in adults. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 5 5 GP/FP/Obstetrics 5 3 Emergency Medicine 4 3 Candesartan-based therapy and risk of cancer in patients with systemic hypertension (Heart Institute of Japan Candesartan Randomized Trial for Evaluation in Coronary Artery Disease substudy). Am J Cardiol Cardiology 5 5 General Practice(GP)/Family Practice(FP) 4 4 General Internal Medicine-Primary Care(US) 4 4
Article Title Discipline Rele- vance News- worthiness Treatment of Bankart Lesions in Traumatic Anterior Instability of the Shoulder: A Randomized Controlled Trial Comparing Arthroscopy and Open Techniques. Arthroscopy Surgery - Orthopaedics 6 4 Comparison of drug-eluting stents with bare metal stents in patients with ST-segment elevation myocardial infarction. Eur Heart J Cardiology 6 5 Early use of noninvasive positive pressure ventilation for acute lung injury: a multicenter randomized controlled trial. Crit Care Med Respirology/Pulmonology 5 5 Catheter ablation for paroxysmal and persistent atrial fibrillation. Cochrane Database Syst Rev Cardiology 4 4 Partner`s presence during initiation of epidural labor analgesia does not decrease maternal stress: a prospective randomized controlled trial. Anesth Analg Obstetrics 6 5 Interventions for preventing excessive weight gain during pregnancy. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 5 4 General Internal Medicine-Primary Care(US) 5 4 Thalidomide for managing cancer cachexia. Cochrane Database Syst Rev Oncology - Palliative and Supportive Care 5 6 Interventions for treating acute elbow dislocations in adults. Cochrane Database Syst Rev Pediatric Emergency Medicine 5 4 Emergency Medicine 5 3 Aromatherapy for treatment of postoperative nausea and vomiting. Cochrane Database Syst Rev Gynecology 6 5 Surgery - Gastrointestinal 6 4 Maternal and infant antiretroviral regimens to prevent postnatal HIV-1 transmission: 48-week follow-up of the BAN randomised controlled trial. Lancet Pediatric Neonatology 6 5 Infectious Disease 5 5 Childhood primary angiitis of the central nervous system: Identifying disease trajectories and early risk factors for persistently higher disease activity. Arthritis Rheum Rheumatology 6 6 Effect of a text messaging intervention on influenza vaccination in an urban, low-income pediatric and adolescent population: a randomized controlled trial. JAMA General Practice(GP)/Family Practice(FP) 5 5 Infectious Disease 4 4 Meta-analysis of long-term outcomes for drug-eluting stents versus bare-metal stents in primary percutaneous coronary interventions for ST-segment elevation myocardial infarction. Am J Cardiol Cardiology 5 5 Warfarin and Aspirin in Patients with Heart Failure and Sinus Rhythm. N Engl J Med Hematology/Thrombosis 7 7 General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6
Article Title Discipline Rele- vance News- worthiness Effects of Celecoxib On Restenosis after Coronary Intervention and Evolution of Atherosclerosis (Mini-COREA) Trial: celecoxib, a double-edged sword for patients with angina. Eur Heart J Cardiology 5 4 Sequential versus single high-dose chemotherapy in patients with relapsed or refractory germ cell tumors: long-term results of a prospective randomized trial. J Clin Oncol Oncology - Genitourinary 6 6 Prevention of Pegfilgrastim-Induced Bone Pain: A Phase III Double-Blind Placebo-Controlled Randomized Clinical Trial of the University of Rochester Cancer Center Clinical Community Oncology Program Research Base. J Clin Oncol Oncology - General 6 5 Anesthesiology 3 3 Fast-Track Surgery Improves Postoperative Clinical Recovery and Immunity After Elective Surgery for Colorectal Carcinoma: Randomized Controlled Clinical Trial. World J Surg Oncology - Gastrointestinal 5 5 Botulinum toxin for myofascial pain syndromes in adults. Cochrane Database Syst Rev Special Interest - Pain -- Physician 5 5 Risk Assessment for Continuous Flow Left Ventricular Assist Devices: Does the Destination Therapy Risk Score Work?: An Analysis of Over 1,000 Patients. J Am Coll Cardiol Cardiology 6 5 Surgery - Cardiac 5 5 The usefulness of HbA1c in postpartum reclassification of gestational diabetes. BJOG Internal Medicine 6 6
Article Title Discipline Rele- vance News- worthiness The effects of isoflurane and desflurane on cognitive function in humans. Anesth Analg Anesthesiology 6 4 Preoperative Versus Postoperative Chemoradiotherapy for Locally Advanced Rectal Cancer: Results of the German CAO/ARO/AIO-94 Randomized Phase III Trial After a Median Follow-Up of 11 Years. J Clin Oncol Oncology - Gastrointestinal 6 5 Optimal Colorectal Cancer Staging Criteria in TNM Classification. J Clin Oncol Oncology - Gastrointestinal 5 5 Salvage Chemotherapy for Pretreated Gastric Cancer: A Randomized Phase III Trial Comparing Chemotherapy Plus Best Supportive Care With Best Supportive Care Alone. J Clin Oncol Oncology - Gastrointestinal 7 5 Genome-wide fetal aneuploidy detection by maternal plasma DNA sequencing. Obstet Gynecol Genetics 7 6 Angiotensin converting enzyme inhibitors are not associated with respiratory complications or mortality after noncardiac surgery. Anesth Analg Anesthesiology 6 6 Surgery - General 5 3 Volume-limited versus pressure-limited hemodynamic management in septic and nonseptic shock. Crit Care Med Intensivist/Critical Care 6 6 Management of reported decreased fetal movements for improving pregnancy outcomes. Cochrane Database Syst Rev Obstetrics 6 5 Vandetanib Versus Placebo in Patients With Advanced Non-Small-Cell Lung Cancer After Prior Therapy With an Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor: A Randomized, Double-Blind Phase III Trial (ZEPHYR). J Clin Oncol Oncology - Lung 5 4 The effect of the Talking Diabetes consulting skills intervention on glycaemic control and quality of life in children with type 1 diabetes: cluster randomised controlled trial (DEPICTED study). BMJ Endocrine 5 4 General Practice(GP)/Family Practice(FP) 4 3 Anticholinergic therapy for acute asthma in children. Cochrane Database Syst Rev Pediatrics (General) 6 5 Allergy and Immunology 5 6 Vaccination against pandemic A/H1N1 2009 influenza in pregnancy and risk of fetal death: cohort study in Denmark. BMJ General Practice(GP)/Family Practice(FP) 6 5
Article Title Discipline Rele- vance News- worthiness Double-blind, randomized trial of docetaxel plus vandetanib versus docetaxel plus placebo in platinum-pretreated metastatic urothelial cancer. J Clin Oncol Oncology - Genitourinary 4 5 Effects of levosimendan on mortality and hospitalization. A meta-analysis of randomized controlled studies. Crit Care Med Surgery - Cardiac 7 6 Cladribine, But Not Fludarabine, Added to Daunorubicin and Cytarabine During Induction Prolongs Survival of Patients With Acute Myeloid Leukemia: A Multicenter, Randomized Phase III Study. J Clin Oncol Oncology - Hematology 5 5 Meta-analysis of Randomized Controlled Trials of Vancomycin for the Treatment of Patients With Gram-Positive Infections: Focus on the Study Design. Mayo Clin Proc Hospital Doctor/Hospitalists 5 5 Internal Medicine 5 5 A multicenter mortality prediction model for patients receiving prolonged mechanical ventilation. Crit Care Med Intensivist/Critical Care 5 5 Eplerenone and Atrial Fibrillation in Mild Systolic Heart Failure: Results From the EMPHASIS-HF (Eplerenone in Mild Patients Hospitalization And SurvIval Study in Heart Failure) Study. J Am Coll Cardiol Internal Medicine 6 6 RSA prediction of high failure rate for the uncoated Interax TKA confirmed by meta-analysis. Acta Orthop Surgery - Orthopaedics 5 4 A Scoring System to Predict Unplanned Intubation in Patients Having Undergone Major Surgical Procedures. Anesth Analg Anesthesiology 6 5 Antifibrinolytic therapy to reduce haemoptysis from any cause. Cochrane Database Syst Rev Hospital Doctor/Hospitalists 5 5 Internal Medicine 5 5 Monoamine oxidase inhibitors (MAOIs) for fibromyalgia syndrome. Cochrane Database Syst Rev Rheumatology 5 5 Usefulness of transesophageal echocardiography to confirm clinical utility of CHA2DS2-VASc and CHADS2 scores in atrial flutter. Am J Cardiol Cardiology 5 5
Article Title Discipline Rele- vance News- worthiness Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basal-bolus treatment with mealtime insulin aspart in type 2 diabetes (BEGIN Basal-Bolus Type 2): a phase 3, randomised, open-label, treat-to-target non-inferiority trial. Lancet General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 Hormone Therapy and Different Ovarian Cancers: A National Cohort Study. Am J Epidemiol Oncology - Gynecology 6 5 Helminth therapy (worms) for allergic rhinitis. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 4 4 General Internal Medicine-Primary Care(US) 4 4 Effectiveness of Mindfulness-Based Stress Reduction in Mood, Breast- and Endocrine-Related Quality of Life, and Well-Being in Stage 0 to III Breast Cancer: A Randomized, Controlled Trial. J Clin Oncol Oncology - Palliative and Supportive Care 5 4 Increasing incidence of melanoma among young adults: an epidemiological study in Olmsted county, Minnesota. Mayo Clin Proc Dermatology 6 4 Improving survival of extremely preterm infants born between 22 and 25 weeks of gestation. Obstet Gynecol Pediatric Neonatology 7 6 A primary care-based, multicomponent lifestyle intervention for overweight adolescent females. Pediatrics Endocrine 5 4 Trastuzumab containing regimens for early breast cancer. Cochrane Database Syst Rev Oncology - Breast 6 5 Meta-Analysis of Efficacy and Safety of New Oral Anticoagulants (Dabigatran, Rivaroxaban, Apixaban) Versus Warfarin in Patients With Atrial Fibrillation. Am J Cardiol General Practice(GP)/Family Practice(FP) 7 7 General Internal Medicine-Primary Care(US) 7 7 The role of fibrin glue instillation under skin flaps in the prevention of seroma formation and related morbidities following breast and axillary surgery for breast cancer: A meta-analysis. J Surg Oncol Surgery - Oncology 6 7 Derivation and validation of a risk adjustment model for predicting seven day mortality in emergency medical admissions: mixed prospective and retrospective cohort study. BMJ Emergency Medicine 5 5
Article Title Discipline Rele- vance News- worthiness Randomized trial of optimal treatment strategies for in-stent restenosis after drug-eluting stent implantation. J Am Coll Cardiol Cardiology 6 5 Lapatinib versus trastuzumab in combination with neoadjuvant anthracycline-taxane-based chemotherapy (GeparQuinto, GBG 44): a randomised phase 3 trial. Lancet Oncol Oncology - Breast 6 5 Valacyclovir suppressive therapy reduces plasma and breast milk HIV-1 RNA levels during pregnancy and postpartum: a randomized trial. J Infect Dis Infectious Disease 6 6 Total hip arthroplasty versus resurfacing arthroplasty in the treatment of patients with arthritis of the hip joint: single centre, parallel group, assessor blinded, randomised controlled trial. BMJ Surgery - Orthopaedics 6 6 Sexual function in nondepressed women using escitalopram for vasomotor symptoms: a randomized controlled trial. Obstet Gynecol General Practice(GP)/Family Practice(FP) 5 6 General Internal Medicine-Primary Care(US) 5 6 Drug-Eluting vs Bare-Metal Stents in Primary Angioplasty: A Pooled Patient-Level Meta-analysis of Randomized Trials. Arch Intern Med Cardiology 5 4 Sorafenib in Combination With Capecitabine: An Oral Regimen for Patients With HER2-Negative Locally Advanced or Metastatic Breast Cancer. J Clin Oncol Oncology - Breast 6 5 Anaesthesia for evacuation of incomplete miscarriage. Cochrane Database Syst Rev GP/FP/Obstetrics 5 4 Postoperative levonorgestrel-releasing intrauterine system for pelvic endometriosis-related pain: a randomized controlled trial. Obstet Gynecol Gynecology 6 4 Modifications of the Epley (canalith repositioning) manoeuvre for posterior canal benign paroxysmal positional vertigo (BPPV). Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5
Article Title Discipline Rele- vance News- worthiness Complications of Wrist Arthroscopy. Arthroscopy Surgery - Orthopaedics 6 5 Haloperidol prophylaxis decreases delirium incidence in elderly patients after noncardiac surgery: a randomized controlled trial. Crit Care Med Intensivist/Critical Care 5 4 Induction of prehospital therapeutic hypothermia after resuscitation from nonventricular fibrillation cardiac arrest. Crit Care Med Cardiology 4 5 Patellar taping for patellofemoral pain syndrome in adults. Cochrane Database Syst Rev Special Interest - Pain -- Physician 5 4 Serum Mesothelin for Diagnosing Malignant Pleural Mesothelioma: An Individual Patient Data Meta-Analysis. J Clin Oncol Oncology - Lung 6 5 FACT: An Open-Label Randomized Phase III Study of Fulvestrant and Anastrozole in Combination Compared With Anastrozole Alone as First-Line Therapy for Patients With Receptor-Positive Postmenopausal Breast Cancer. J Clin Oncol Oncology - Breast 5 5 Web-based tailored education program for disease-free cancer survivors with cancer-related fatigue: a randomized controlled trial. J Clin Oncol General Practice(GP)/Family Practice(FP) 4 4 General Internal Medicine-Primary Care(US) 4 4 Reduction in Sodium Content of Local Anesthetics for Peripheral Nerve Blocks. A Comparative Evaluation of Saline with 5% Dextrose: A Randomized Controlled Double-Blind Study. Anesth Analg Anesthesiology 6 6 Accelerated Radiotherapy With Carbogen and Nicotinamide for Laryngeal Cancer: Results of a Phase III Randomized Trial. J Clin Oncol Oncology - General 5 5 Interventions for the management of temporomandibular joint osteoarthritis. Cochrane Database Syst Rev Special Interest - Pain -- Physician 5 4 Amiodarone Significantly Decreases Atrial Fibrillation in Patients Undergoing Surgery for Lung Cancer. Ann Thorac Surg Anesthesiology 5 4 The safety of early versus late ambulation in the management of patients after percutaneous coronary interventions: A meta-analysis. Int J Nurs Stud Cardiology 5 5 How should I wean my next intra-aortic balloon pump? Differences between progressive volume weaning and rate weaning. J Thorac Cardiovasc Surg Intensivist/Critical Care 7 7 First-SIGNAL: First-Line Single-Agent Iressa Versus Gemcitabine and Cisplatin Trial in Never-Smokers With Adenocarcinoma of the Lung. J Clin Oncol Respirology/Pulmonology 6 5 Oncology - Lung 5 5 Botulinum toxin A for prophylactic treatment of migraine and tension headaches in adults: a meta-analysis. JAMA General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Neurology 6 5
Article Title Discipline Rele- vance News- worthiness Minimally Invasive Total Knee Arthroplasty Improves Early Knee Strength But Not Functional Performance: A Randomized Controlled Trial. J Arthroplasty Surgery - Orthopaedics 6 5 Agreement between colposcopic impression and histological diagnosis among human papillomavirus type 16-positive women: a clinical trial using dynamic spectral imaging colposcopy. BJOG Gynecology 6 5 A weight-loss diet including coffee-derived mannooligosaccharides enhances adipose tissue loss in overweight men but not women. Obesity (Silver Spring) General Practice(GP)/Family Practice(FP) 5 6 General Internal Medicine-Primary Care(US) 5 6 Concurrent chemoradiotherapy plus adjuvant chemotherapy versus concurrent chemoradiotherapy alone in patients with locoregionally advanced nasopharyngeal carcinoma: a phase 3 multicentre randomised controlled trial. Lancet Oncol Oncology - General 6 6 Epidural steroids, etanercept, or saline in subacute sciatica: a multicenter, randomized trial. Ann Intern Med Special Interest - Pain -- Physician 6 6 Switch to adalimumab in patients with Crohn`s disease controlled by maintenance infliximab: prospective randomised SWITCH trial. Gut Gastroenterology 6 6 First-Line Treatment of Advanced Breast Cancer With Sunitinib in Combination With Docetaxel Versus Docetaxel Alone: Results of a Prospective, Randomized Phase III Study. J Clin Oncol Oncology - Breast 6 5 Effects of an uncertainty management intervention on uncertainty, anxiety, depression, and quality of life of chronic obstructive pulmonary disease outpatients. Res Nurs Health Psychiatry 5 4 General Practice(GP)/Family Practice(FP) 4 4 General Internal Medicine-Primary Care(US) 4 4 Comparison of Oligon catheters and chlorhexidine-impregnated sponges with standard multilumen central venous catheters for prevention of associated colonization and infections in intensive care unit patients: a multicenter, randomized, controlled study. Crit Care Med Intensivist/Critical Care 5 4 Negative pressure wound therapy for skin grafts and surgical wounds healing by primary intention. Cochrane Database Syst Rev Hospital Doctor/Hospitalists 5 4 Internal Medicine 5 4 Exercise interventions for shoulder dysfunction in patients treated for head and neck cancer. Cochrane Database Syst Rev Surgery - Oncology 7 6 Low-dose abdominal CT for evaluating suspected appendicitis. N Engl J Med Emergency Medicine 6 6 Cervical stitch (cerclage) for preventing preterm birth in singleton pregnancy. Cochrane Database Syst Rev Obstetrics 7 5 Pediatric Neonatology 6 6 Enabling health care decisionmaking through clinical decision support and knowledge management. Evid Rep Technol Assess General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5
Article Title Discipline Rele- vance News- worthiness Glasgow supported self-management trial (GSuST) for patients with moderate to severe COPD: randomised controlled trial. BMJ Respirology/Pulmonology 5 4 Randomized trial using gonadotropin-releasing hormone agonist triptorelin for the preservation of ovarian function during (neo)adjuvant chemotherapy for breast cancer. J Clin Oncol Gynecology 6 6 Oncology - Breast 5 5 Randomized phase III study comparing paclitaxel-bleomycin, etoposide, and cisplatin (BEP) to standard BEP in intermediate-prognosis germ-cell cancer: intergroup study EORTC 30983. J Clin Oncol Oncology - Genitourinary 6 5 First Results of the DEB-AMI (Drug Eluting Balloon in Acute ST-Segment Elevation Myocardial Infarction) Trial: A Multicenter Randomized Comparison of Drug-Eluting Balloon Plus Bare-Metal Stent Versus Bare-Metal Stent Versus Drug-Eluting Stent in Primary Percutaneous Coronary Intervention With 6-Month Angiographic, Intravascular, Functional, and Clinical Outcomes. J Am Coll Cardiol Cardiology 5 5 Phase III Trial Evaluating Weekly Paclitaxel Versus Docetaxel in Combination With Capecitabine in Operable Breast Cancer. J Clin Oncol Oncology - Breast 5 4 Are Femoral Nerve Blocks Effective for Early Postoperative Pain Management After Hip Arthroscopy?. Arthroscopy Anesthesiology 6 5 The effectiveness of SPARX, a computerised self help intervention for adolescents seeking help for depression: randomised controlled non-inferiority trial. BMJ Psychiatry 6 5 Palliative Sedation in End-of-Life Care and Survival: A Systematic Review. J Clin Oncol Oncology - Palliative and Supportive Care 6 6 Oncology - General 6 4 Effect of Clinical Decision-Support Systems: A Systematic Review. Ann Intern Med Hospital Doctor/Hospitalists 6 4 Internal Medicine 6 4 General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 On-Pump versus Off-Pump Coronary Artery Bypass Surgery in Elderly Patients: Results from the Danish On-Pump versus Off-Pump Randomization Study (DOORS). Circulation Surgery - Cardiac 7 4 Geriatrics 6 5 Risk of Clostridium difficile Infection With Acid Suppressing Drugs and Antibiotics: Meta-Analysis. Am J Gastroenterol General Practice(GP)/Family Practice(FP) 7 6 General Internal Medicine-Primary Care(US) 7 6 Gastroenterology 5 4 Dopamine versus norepinephrine in the treatment of septic shock: a meta-analysis. Crit Care Med Emergency Medicine 7 5 Intensivist/Critical Care 7 5 C1-esterase inhibitor infusion increases survival rates for patients with sepsis. Crit Care Med Infectious Disease 5 5 CHADS(2) and CHA(2)DS(2)-VASc Risk Factors to Predict First Cardiovascular Hospitalization Among Atrial Fibrillation/Atrial Flutter Patients. Am J Cardiol Internal Medicine 5 4 Cardiology 5 4 CT screening for lung cancer brings forward early disease. The randomised Danish Lung Cancer Screening Trial: status after five annual screening rounds with low-dose CT. Thorax General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5
Article Title Discipline Rele- vance News- worthiness Induction therapy with autologous mesenchymal stem cells in living-related kidney transplants: a randomized controlled trial. JAMA Nephrology 6 7 The PROFI Study (Prevention of Cerebral Embolization by Proximal Balloon Occlusion Compared to Filter Protection During Carotid Artery Stenting): A Prospective Randomized Trial. J Am Coll Cardiol Neurology 5 5 Cardiology 4 6 Angiotensin-converting enzyme inhibitors reduce mortality in hypertension: a meta-analysis of randomized clinical trials of renin-angiotensin-aldosterone system inhibitors involving 158 998 patients. Eur Heart J General Practice(GP)/Family Practice(FP) 5 4 General Internal Medicine-Primary Care(US) 5 4 Golimumab, a human TNF-alpha antibody, administered every 4 weeks as a subcutaneous injection in psoriatic arthritis: Clinical efficacy, radiographic, and safety findings through 1year of the randomized, placebo-controlled, GO-REVEAL(R) study. Arthritis Rheum Dermatology 6 6 Meta-Analysis of Randomized Controlled Trials on Effect of Cilostazol on Restenosis Rates and Outcomes After Percutaneous Coronary Intervention. Am J Cardiol Cardiology 5 4 Angiotensin receptor blockers for heart failure. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 7 6 General Internal Medicine-Primary Care(US) 7 6 Hospital Doctor/Hospitalists 6 5 Internal Medicine 6 5 Cardiology 6 5 Meta-analysis of ten trials on the effectiveness of the radial versus the femoral approach in primary percutaneous coronary intervention. Am J Cardiol Internal Medicine 6 6 Cardiology 5 5 Fermented milk for hypertension. Cochrane Database Syst Rev Internal Medicine 5 3 Cardiology 4 5 Interventions for restoring patency of occluded central venous catheter lumens. Cochrane Database Syst Rev Oncology - Pediatric 6 4 Oncology - Breast 4 4
Article Title Discipline Rele- vance News- worthiness Efficacy and safety of colchicine for pericarditis prevention. Systematic review and meta-analysis. Heart Cardiology 6 4 Changing Clinical Practice Through Patient Specific Reminders Available at the Time of the Clinical Encounter: Systematic Review and Meta-Analysis. J Gen Intern Med General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 Concomitant chemoradiotherapy versus acceleration of radiotherapy with or without concomitant chemotherapy in locally advanced head and neck carcinoma (GORTEC 99-02): an open-label phase 3 randomised trial. Lancet Oncol Oncology - General 5 5 The effects of extended pre-quit varenicline treatment on smoking behavior and short-term abstinence: a randomized clinical trial. Clin Pharmacol Ther General Practice(GP)/Family Practice(FP) 6 7 General Internal Medicine-Primary Care(US) 6 7 Effects of combining simvastatin with rosiglitazone on inflammation, oxidant stress and ambulatory blood pressure in patients with the metabolic syndrome: the SIROCO study. Diabetes Obes Metab Endocrine 5 5 General Practice(GP)/Family Practice(FP) 5 3 General Internal Medicine-Primary Care(US) 5 3 Naproxen or estradiol for bleeding and spotting with the levonorgestrel intrauterine system: a randomized controlled trial. Am J Obstet Gynecol Gynecology 5 6 General Practice(GP)/Family Practice(FP) 5 4 Efficiency of neonatal screening for congenital adrenal hyperplasia due to 21-hydroxylase deficiency in children born in mainland France between 1996 and 2003. Arch Pediatr Adolesc Med Public Health 6 5 Dose-Intensification in Early Unfavorable Hodgkin`s Lymphoma: Final Analysis of the German Hodgkin Study Group HD14 Trial. J Clin Oncol Oncology - Hematology 6 6 Screening for distress and unmet needs in patients with cancer: review and recommendations. J Clin Oncol Oncology - Palliative and Supportive Care 6 5 Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basal-bolus treatment with mealtime insulin aspart in type 1 diabetes (BEGIN Basal-Bolus Type 1): a phase 3, randomised, open-label, treat-to-target non-inferiority trial. Lancet Internal Medicine 6 6 General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 Effect of the bevel direction of puncture needle on success rate and complications during internal jugular vein catheterization. Crit Care Med Intensivist/Critical Care 5 5
Article Title Discipline Rele- vance News- worthiness Feasibility of closed-loop titration of propofol and remifentanil guided by the spectral M-Entropy monitor. Anesthesiology Anesthesiology 5 6 The relationship between CYP2C19 polymorphisms and ischaemic and bleeding outcomes in stable outpatients: the CHARISMA genetics study. Eur Heart J Cardiology 5 5 Tight Glycemic Control With Insulin in Hyperglycemic Preterm Babies: A Randomized Controlled Trial. Pediatrics Endocrine 5 5 Effects of Sevelamer on HbA1c, Inflammation, and Advanced Glycation End Products in Diabetic Kidney Disease. Clin J Am Soc Nephrol Endocrine 5 6 Dose equivalence of immediate-release hydromorphone and once-daily osmotic-controlled extended-release hydromorphone: a randomized, double-blind trial incorporating a measure of assay sensitivity. J Pain General Practice(GP)/Family Practice(FP) 4 5 General Internal Medicine-Primary Care(US) 4 5 Systematic Review: Benefits and Harms of Pharmacologic Treatment for Urinary Incontinence in Women. Ann Intern Med Gynecology 5 4 Long-Term Follow-Up of Gut-Directed Hypnotherapy vs. Standard Care in Children With Functional Abdominal Pain or Irritable Bowel Syndrome. Am J Gastroenterol Special Interest - Pain -- Physician 5 7 Pediatrics (General) 5 6 The effects of dietary weight loss with or without exercise training on liver enzymes in obese metabolic syndrome subjects. Diabetes Obes Metab Gastroenterology 5 5 General Practice(GP)/Family Practice(FP) 4 3 General Internal Medicine-Primary Care(US) 4 3 Efficacy and safety of mitiglinide versus nateglinide in newly diagnose patients with type 2 diabetes mellitus: a randomized double blind trial. Diabetes Obes Metab General Practice(GP)/Family Practice(FP) 4 4 General Internal Medicine-Primary Care(US) 4 4 Longer-term outcomes of letrozole versus placebo after 5 years of tamoxifen in the NCIC CTG MA.17 trial: analyses adjusting for treatment crossover. J Clin Oncol Oncology - Breast 6 5 Tamoxifen and anastrozole as a sequencing strategy: a randomized controlled trial in postmenopausal patients with endocrine-responsive early breast cancer from the Austrian Breast and Colorectal Cancer Study Group. J Clin Oncol Oncology - Breast 6 6 New comprehensive cytogenetic scoring system for primary myelodysplastic syndromes (MDS) and oligoblastic acute myeloid leukemia after MDS derived from an international database merge. J Clin Oncol Oncology - Hematology 6 6 Comparative effectiveness of antibiotics for uncomplicated urinary tract infections: Network meta-analysis of randomized trials. Fam Pract Infectious Disease 5 4 Pediatrics (General) 5 3 Gynecology 4 4 Meta-analysis of prospective randomized controlled trials comparing intracoronary versus intravenous abciximab in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention. Am J Cardiol Cardiology 5 5
Article Title Discipline Rele- vance News- worthiness A mixed treatment comparison of the efficacy of anti-TNF agents in rheumatoid arthritis for methotrexate non-responders demonstrates differences between treatments: a Bayesian approach. Ann Rheum Dis Rheumatology 6 4 Incidence and timing of presentation of necrotizing enterocolitis in preterm infants. Pediatrics Pediatric Neonatology 6 5 Additional use of trimetazidine in patients with chronic heart failure: a meta-analysis. J Am Coll Cardiol Cardiology 6 5 Treatment for superficial thrombophlebitis of the leg. Cochrane Database Syst Rev Hospital Doctor/Hospitalists 5 6 Internal Medicine 5 6 Hematology/Thrombosis 5 5 Most Effective Regimen of Tranexamic Acid in Knee Arthroplasty: A Prospective Randomized Controlled Study in 240 Patients. Clin Orthop Relat Res Surgery - Orthopaedics 5 5 Restricted intravenous fluid regimen reduces the rate of postoperative complications and alters immunological activity of elderly patients operated for abdominal cancer: a randomized prospective clinical trail. World J Surg Surgery - Oncology 5 5 Anesthesiology 5 4 Interventions to support a palliative care approach in patients with chronic obstructive pulmonary disease: An integrative review. Int J Nurs Stud Hospital Doctor/Hospitalists 5 5 Internal Medicine 5 5 Respirology/Pulmonology 5 4 Effects of Six versus Three Times per Week Hemodialysis on Physical Performance, Health, and Functioning: Frequent Hemodialysis Network (FHN) Randomized Trials. Clin J Am Soc Nephrol Nephrology 5 5 A Randomized, Multicenter, Single-Blinded Trial Comparing Paclitaxel-Coated Balloon Angioplasty With Plain Balloon Angioplasty in Drug-Eluting Stent Restenosis: The PEPCAD-DES Study. J Am Coll Cardiol Cardiology 5 4 Continuous epicapsular ropivacaine 0.3% infusion after minimally invasive hip arthroplasty: a prospective, randomized, double-blinded, placebo-controlled study comparing continuous wound infusion with morphine patient-controlled analgesia. Anesth Analg Anesthesiology 5 5 Detection of synovitis in the hands of patients with rheumatological disorders: Diagnostic performance of optical imaging in comparison to MRI. Arthritis Rheum Rheumatology 6 6 Pulmonary function over 2 years in diabetic patients treated with prandial inhaled Technosphere Insulin or usual antidiabetes treatment: a randomized trial. Diabetes Obes Metab Endocrine 4 4 Performance of risk indices for identifying low bone mineral density and osteoporosis in Mexican Mestizo women with rheumatoid arthritis. J Rheumatol Rheumatology 5 5 Vaginal progesterone in women with an asymptomatic sonographic short cervix in the midtrimester decreases preterm delivery and neonatal morbidity: a systematic review and metaanalysis of individual patient data. Am J Obstet Gynecol Pediatric Neonatology 6 6 Percutaneous atrial appendage occlusion for stroke prevention in patients with atrial fibrillation: a systematic review. Heart Internal Medicine 6 5
Article Title Discipline Rele- vance News- worthiness Progestagens and anti-progestagens for pain associated with endometriosis. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6 Gynecology 6 5 Influence of Rescrubbing Before Laparotomy Closure on Abdominal Wound Infection After Colorectal Cancer Surgery: Results of a Multicenter Randomized Clinical Trial. Arch Surg Surgery - General 6 5 Management of asymptomatic inguinal hernia: a systematic review of the evidence. Arch Surg Surgery - General 6 5 Gastroenterology 5 5 Pyronaridine-artesunate versus mefloquine plus artesunate for malaria. N Engl J Med Tropical and Travel Medicine 6 5 Recurrence and survival after random assignment to laparoscopy versus laparotomy for comprehensive surgical staging of uterine cancer: Gynecologic Oncology Group LAP2 Study. J Clin Oncol Oncology - Genitourinary 5 5 The efficacy of intravenous patient-controlled analgesia after intracranial surgery of the posterior fossa: a prospective, randomized controlled trial. Anesth Analg Special Interest - Pain -- Physician 5 5 Surgery - Neurosurgery 5 4 Reslizumab in children and adolescents with eosinophilic esophagitis: results of a double-blind, randomized, placebo-controlled trial. J Allergy Clin Immunol Allergy and Immunology 6 6 Intravenous aflibercept for treatment of recurrent symptomatic malignant ascites in patients with advanced ovarian cancer: a phase 2, randomised, double-blind, placebo-controlled study. Lancet Oncol Oncology - Gynecology 6 6 Long-term results of a randomized controlled trial on ultrasound-guided foam sclerotherapy combined with saphenofemoral ligation vs standard surgery for varicose veins. J Vasc Surg Surgery - Vascular 5 5 Prosthetic H-Graft Portacaval Shunts vs Transjugular Intrahepatic Portasystemic Stent Shunts: 18-Year Follow-Up of a Randomized Trial. J Am Coll Surg Gastroenterology 5 5 Treatment effectiveness of two Chinese herbal medicine formulae in upper respiratory tract infections--a randomized double-blind placebo-controlled trial. Fam Pract Respirology/Pulmonology 4 5 General Practice(GP)/Family Practice(FP) 4 3 General Internal Medicine-Primary Care(US) 4 3 Primary Endpoint Results of the EVOLVE Trial: A Randomized Evaluation of a Novel Bioabsorbable Polymer-Coated, Everolimus-Eluting Coronary Stent. J Am Coll Cardiol Cardiology 5 6 Risk of cancer in first seven years after metal-on-metal hip replacement compared with other bearings and general population: linkage study between the National Joint Registry of England and Wales and hospital episode statistics. BMJ Surgery - Orthopaedics 7 6 Oncology - General 5 5 Disease-related outcomes with long-term follow-up: an updated analysis of the intergroup exemestane study. J Clin Oncol Oncology - Breast 6 4 A meta-analysis of the use of nonsteroidal antiinflammatory drugs for pediatric postoperative pain. Anesth Analg Pediatric Hospital Medicine 6 5 The Prevention of Chronic Postsurgical Pain Using Gabapentin and Pregabalin: A Combined Systematic Review and Meta-Analysis. Anesth Analg Gynecology 6 6 Anesthesiology 6 5 Surgery - Orthopaedics 5 5 Comparison of metformin and insulin versus insulin alone for type 2 diabetes: systematic review of randomised clinical trials with meta-analyses and trial sequential analyses. BMJ Internal Medicine 6 6 General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Endocrine 5 4
Article Title Discipline Rele- vance News- worthiness Sodium chloride vs. sodium bicarbonate for the prevention of contrast medium-induced nephropathy: a randomized controlled trial. Eur Heart J Internal Medicine 6 6 Esophageal guidewire-assisted nasogastric tube insertion in anesthetized and intubated patients: a prospective randomized controlled study. Anesth Analg Anesthesiology 5 5 Aromatherapy as Treatment for Postoperative Nausea: A Randomized Trial. Anesth Analg Anesthesiology 5 6 New fibrate use and acute renal outcomes in elderly adults: a population-based study. Ann Intern Med Nephrology 6 5 A Randomized Controlled Trial of Telemonitoring in Older Adults With Multiple Health Issues to Prevent Hospitalizations and Emergency Department Visits. Arch Intern Med General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 Esomeprazole Alone Compared with Esomeprazole Plus Aspirin for the Treatment of Aspirin-Related Peptic Ulcers. Am J Gastroenterol General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6
Article Title Discipline Rele- vance News- worthiness Role of Antibiotic Therapy in Mild Acute Calculus Cholecystitis: A Prospective Randomized Controlled Trial. World J Surg Infectious Disease 6 5 Effect of gemtuzumab ozogamicin on survival of adult patients with de-novo acute myeloid leukaemia (ALFA-0701): a randomised, open-label, phase 3 study. Lancet Oncology - Hematology 7 6 Firategrast for relapsing remitting multiple sclerosis: a phase 2, randomised, double-blind, placebo-controlled trial. Lancet Neurol Neurology 5 6 Subthalamic deep brain stimulation with a constant-current device in Parkinson`s disease: an open-label randomised controlled trial. Lancet Neurol Neurology 6 6 Perioperative single dose ketorolac to prevent postoperative pain: a meta-analysis of randomized trials. Anesth Analg Surgery - Gastrointestinal 6 5
Article Title Discipline Rele- vance News- worthiness Single-bundle versus double-bundle reconstruction for anterior cruciate ligament rupture: a meta-analysis-does anatomy matter?. Arthroscopy Surgery - Orthopaedics 6 4 Special article: dexamethasone for the prophylaxis of postoperative nausea and vomiting associated with neuraxial morphine administration: a systematic review and meta-analysis. Anesth Analg Obstetrics 5 4 Targeted Left Ventricular Lead Placement to Guide Cardiac Resynchronization Therapy: The TARGET Study: A Randomized, Controlled Trial. J Am Coll Cardiol Cardiology 5 5 Prediction of post-remission survival in acute myeloid leukaemia: a post-hoc analysis of the AML96 trial. Lancet Oncol Oncology - Hematology 6 5 Male circumcision and herpes simplex virus type 2 infection in female partners: a randomized trial in Rakai, Uganda. J Infect Dis Infectious Disease 4 4 General Practice(GP)/Family Practice(FP) 4 3 General Internal Medicine-Primary Care(US) 4 3 A Randomized Controlled Trial in Second-Generation Zotarolimus-Eluting Resolute Stents Versus Everolimus-Eluting Xience V Stents in Real-World Patients: The TWENTE Trial. J Am Coll Cardiol Cardiology 4 4
Article Title Discipline Rele- vance News- worthiness Phase II, open-label, randomized, multicenter study comparing the efficacy and safety of olaparib, a poly (ADP-ribose) polymerase inhibitor, and pegylated liposomal doxorubicin in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer. J Clin Oncol Oncology - Gynecology 4 4 The role of perioperative high inspired oxygen therapy in reducing surgical site infection: a meta-analysis. Anesth Analg Anesthesiology 5 5 A randomized trial testing a contingency-based weight loss intervention involving social reinforcement. Obesity (Silver Spring) General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 Effect of statins on ventricular tachyarrhythmia, cardiac arrest, and sudden cardiac death: a meta-analysis of published and unpublished evidence from randomized trials. Eur Heart J Cardiology 4 4 The controversy of managing calf vein thrombosis. J Vasc Surg Surgery - Vascular 6 5 General Practice(GP)/Family Practice(FP) 6 4 General Internal Medicine-Primary Care(US) 6 4
Article Title Discipline Rele- vance News- worthiness A clinicopathologic study of thrombotic microangiopathy in IgA nephropathy. J Am Soc Nephrol Nephrology 6 6 Health-Related Quality of Life and Direct Costs in Patients With Anterior Cruciate Ligament Injury: Single-Bundle Versus Double-Bundle Reconstruction in a Low-Demand Cohort-A Randomized Trial With 2 Years of Follow-up. Arthroscopy Surgery - Orthopaedics 5 5 Trial of early aggressive therapy in polyarticular juvenile idiopathic arthritis. Arthritis Rheum Rheumatology 6 6 Predicting outcome of IV thrombolysis-treated ischemic stroke patients: the DRAGON score. Neurology Hospital Doctor/Hospitalists 6 6 Internal Medicine 6 6 Single-incision mini-sling compared with tension-free vaginal tape for the treatment of stress urinary incontinence: a randomized controlled trial. Obstet Gynecol Surgery - Urology 5 4 Micronutrient supplementation in pregnant women with HIV infection. Cochrane Database Syst Rev Pediatric Neonatology 4 5 Reduced-intensity chemotherapy and PET-guided radiotherapy in patients with advanced stage Hodgkin`s lymphoma (HD15 trial): a randomised, open-label, phase 3 non-inferiority trial. Lancet Oncology - Hematology 6 6 A Randomized Trial of Rectal Indomethacin to Prevent Post-ERCP Pancreatitis. N Engl J Med Gastroenterology 6 6 Association of treatment with losartan vs candesartan and mortality among patients with heart failure. JAMA General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6 Cardiology 5 5 Efficacy and safety of rituximab in patients with active proliferative lupus nephritis: the Lupus Nephritis Assessment with Rituximab study. Arthritis Rheum Nephrology 6 5 Randomized phase III study of thoracic radiation in combination with paclitaxel and carboplatin with or without thalidomide in patients with stage III non-small-cell lung cancer: the ECOG 3598 study. J Clin Oncol Respirology/Pulmonology 6 6 Oncology - Lung 5 5 Association of subcutaneous allergen-specific immunotherapy with incidence of autoimmune disease, ischemic heart disease, and mortality. J Allergy Clin Immunol Allergy and Immunology 6 6 Gemcitabine and oxaliplatin with or without erlotinib in advanced biliary-tract cancer: a multicentre, open-label, randomised, phase 3 study. Lancet Oncol Oncology - Gastrointestinal 5 6 Noninferiority of miltefosine versus meglumine antimoniate for cutaneous leishmaniasis in children. J Infect Dis Pediatrics (General) 5 6
Article Title Discipline Rele- vance News- worthiness Less invasive stabilization system (LISS) versus proximal femoral nail anti-rotation (PFNA) in treating proximal femoral fractures: a prospective randomized study. J Orthop Trauma Surgery - Orthopaedics 4 4 Nasal continuous positive airway pressure with heliox in preterm infants with respiratory distress syndrome. Pediatrics Respirology/Pulmonology 6 5 Off-Pump or On-Pump Coronary-Artery Bypass Grafting at 30 Days. N Engl J Med Surgery - Cardiac 6 5 Effectiveness of community- and workplace-based interventions to manage musculoskeletal-related sickness absence and job loss: a systematic review. Rheumatology (Oxford) Occupational and Environmental Health 6 5 General Practice(GP)/Family Practice(FP) 5 4 General Internal Medicine-Primary Care(US) 5 4 Rheumatology 5 3 Urinary proteome analysis to exclude severe vesicoureteral reflux. Pediatrics Nephrology 5 4 Total Hip Arthroplasty Versus Hemiarthroplasty for Displaced Femoral Neck Fractures: Meta-analysis of Randomized Trials. Clin Orthop Relat Res Surgery - Orthopaedics 7 5 Age and diagnostic performance of Alzheimer disease CSF biomarkers. Neurology Neurology 5 5 Antipsychotics for children and young adults: a comparative effectiveness review. Pediatrics Psychiatry 7 4 General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6 Prognostic value of cardiac troponin T after myocardial infarction: a contemporary community experience. Mayo Clin Proc General Practice(GP)/Family Practice(FP) 6 3 General Internal Medicine-Primary Care(US) 6 3 Cardiology 4 5 Effect of oxaliplatin, fluorouracil, and leucovorin with or without cetuximab on survival among patients with resected stage III colon cancer: a randomized trial. JAMA Surgery - Colorectal 6 5 Blood Loss in Cemented THA is not Reduced with Postoperative Versus Preoperative Start of Thromboprophylaxis. Clin Orthop Relat Res Surgery - Orthopaedics 5 6 Efficacy and Safety of Innovator versus Generic Drugs in Patients with Epilepsy: A Systematic Review. Pharmacotherapy General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 Efficacy of Omega-3 Fatty Acid Supplements (Eicosapentaenoic Acid and Docosahexaenoic Acid) in the Secondary Prevention of Cardiovascular Disease: A Meta-analysis of Randomized, Double-blind, Placebo-Controlled Trials. Arch Intern Med General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6 Internal Medicine 6 6 Cardiology 6 6 Meta-analysis of psychosocial interventions to reduce pain in patients with cancer. J Clin Oncol Psychiatry 6 6 Oncology - General 4 5 Does this adult patient have a blunt intra-abdominal injury?. JAMA Emergency Medicine 6 6 General Internal Medicine-Primary Care(US) 4 4 General Practice(GP)/Family Practice(FP) 4 4 Evaluation of a breast cancer nomogram for predicting risk of ipsilateral breast tumor recurrences in patients with ductal carcinoma in situ after local excision. J Clin Oncol Oncology - Breast 6 5
Article Title Discipline Rele- vance News- worthiness Comparison of inside-out and all-inside techniques for the repair of isolated meniscal tears: a systematic review. Am J Sports Med Surgery - Orthopaedics 6 6 Late Results of Percutaneous Mitral Commissurotomy up to 20 Years: Development and Validation of a Risk Score Predicting Late Functional Results from a Series of 912 Patients. Circulation Cardiology 6 6 Surgery - Cardiac 5 4 Effectiveness of non-pharmacological interventions for the prevention of bloodstream infections in infants admitted to a neonatal intensive care unit: A systematic review. Int J Nurs Stud Pediatric Neonatology 6 5 Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND). Cochrane Database Syst Rev Neurology 6 5 Predicting Psychosis: Meta-analysis of Transition Outcomes in Individuals at High Clinical Risk. Arch Gen Psychiatry General Practice(GP)/Family Practice(FP) 4 4 General Internal Medicine-Primary Care(US) 4 4 Proton Pump Inhibitors vs. Histamine 2 Receptor Antagonists for Stress-Related Mucosal Bleeding Prophylaxis in Critically Ill Patients: A Meta-Analysis. Am J Gastroenterol Hematology/Thrombosis 5 4 Somatostatin Analogues for the Treatment of Enterocutaneous Fistulas: A Systematic Review and Meta-analysis. World J Surg Surgery - General 6 5 Safety and efficacy of antibiotics compared with appendicectomy for treatment of uncomplicated acute appendicitis: meta-analysis of randomised controlled trials. BMJ Hospital Doctor/Hospitalists 6 7 Internal Medicine 6 7 Adherence to colorectal cancer screening: a randomized clinical trial of competing strategies. Arch Intern Med General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5
Article Title Discipline Rele- vance News- worthiness Predictive role of capillaroscopic skin ulcer risk index in systemic sclerosis: a multicentre validation study. Ann Rheum Dis Rheumatology 6 6 Efficacy of tocilizumab in patients with moderate to severe active rheumatoid arthritis and a previous inadequate response to disease-modifying antirheumatic drugs: the ROSE study. Ann Rheum Dis Rheumatology 6 6 Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis. N Engl J Med Dermatology 7 7 The effect of intravenous ferric carboxymaltose on health-related quality of life in patients with chronic heart failure and iron deficiency: a subanalysis of the FAIR-HF study. Eur Heart J Cardiology 4 4 Evaluation of risk stratification schemes for ischaemic stroke and bleeding in 182 678 patients with atrial fibrillation: the Swedish Atrial Fibrillation cohort study. Eur Heart J Internal Medicine 7 6 Cardiology 6 6 Hematology/Thrombosis 6 6 Cervical pessary in pregnant women with a short cervix (PECEP): an open-label randomised controlled trial. Lancet GP/FP/Obstetrics 6 7 Ivabradine versus metoprolol for heart rate reduction before coronary computed tomography angiography. Am J Cardiol Cardiology 5 6 Drug-eluting stents versus coronary artery bypass graft surgery in left main coronary artery disease: A meta-analysis of early outcomes from randomized and nonrandomized studies. J Thorac Cardiovasc Surg Surgery - Cardiac 6 4 Just click on the title to review the abstract and/or PubMed record.
Article Title Discipline Rele- vance News- worthiness Benefits From Antidepressants: Synthesis of 6-Week Patient-Level Outcomes From Double-blind Placebo-Controlled Randomized Trials of Fluoxetine and Venlafaxine. Arch Gen Psychiatry Psychiatry 7 7 Transcutaneous electric nerve stimulation (TENS) for cancer pain in adults. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 6 4 General Internal Medicine-Primary Care(US) 6 4 Oncology - Palliative and Supportive Care 5 4 A systematic review and meta-analysis: tailoring asthma treatment on eosinophilic markers (exhaled nitric oxide or sputum eosinophils). Thorax General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 Pain management for women in labour: an overview of systematic reviews. Cochrane Database Syst Rev Anesthesiology 6 5 GP/FP/Anesthesia 5 4 Steroid hormones for contraception in men. Cochrane Database Syst Rev Surgery - Urology 6 5 General Practice(GP)/Family Practice(FP) 3 3 General Internal Medicine-Primary Care(US) 3 3
Article Title Discipline Rele- vance News- worthiness The Frank Stinchfield Award: Dislocation in revision THA: do large heads (36 and 40 mm) result in reduced dislocation rates in a randomized clinical trial?. Clin Orthop Relat Res Surgery - Orthopaedics 5 4 A comparison of a less invasive piriformis-sparing approach versus the standard posterior approach to the hip: A randomised controlled trial. J Bone Joint Surg Br Surgery - Orthopaedics 5 5 Anatomic Bankart Repair Compared With Nonoperative Treatment and/or Arthroscopic Lavage for First-Time Traumatic Shoulder Dislocation. Arthroscopy Surgery - Orthopaedics 6 5 Ketogenic diet and other dietary treatments for epilepsy. Cochrane Database Syst Rev Neurology 6 4 CO(2) inhalation as a treatment for apnea of prematurity: a randomized double-blind controlled trial. J Pediatr Pediatric Neonatology 5 5 Olaparib Maintenance Therapy in Platinum-Sensitive Relapsed Ovarian Cancer. N Engl J Med Oncology - Gynecology 6 6 Outcome of extremely low birth weight infants who received delivery room cardiopulmonary resuscitation. J Pediatr Obstetrics 6 6 Sodium channel blockers for cystic fibrosis. Cochrane Database Syst Rev Pediatrics (General) 6 5 Meta-analysis of statin effects in women versus men. J Am Coll Cardiol Internal Medicine 6 5 Cardiology 6 5 Effect of intravenous tropisetron on modulation of pain and central hypersensitivity in chronic low back pain patients. Pain Rheumatology 4 4 Chitinase enzyme activity in CSF is a powerful biomarker of Alzheimer disease. Neurology Psychiatry 5 6 Higher-dose oxytocin and hemorrhage after vaginal delivery: a randomized controlled trial. Obstet Gynecol Obstetrics 6 6 Out-of-Hospital Administration of Intravenous Glucose-Insulin-Potassium in Patients With Suspected Acute Coronary Syndromes: The IMMEDIATE Randomized Controlled Trial. JAMA Cardiology 6 6 Emergency Medicine 5 4 Analgesic Effect of Breast Milk Versus Sucrose for Analgesia During Heel Lance in Late Preterm Infants. Pediatrics Pediatric Neonatology 5 4
Article Title Discipline Rele- vance News- worthiness Treatment of trigger finger: randomized clinical trial comparing the methods of corticosteroid injection, percutaneous release and open surgery. Rheumatology (Oxford) Rheumatology 5 5 Surgery - Orthopaedics 3 3 Should care managers for older adults be located in primary care? A randomized controlled trial. J Am Geriatr Soc General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6 Geriatrics 6 5 RCT of montelukast as prophylaxis for upper respiratory tract infections in children. Pediatrics Respirology/Pulmonology 6 4 Public Health 5 4 Infectious Disease 5 3 Impact of cane use on pain, function, general health and energy expenditure during gait in patients with knee osteoarthritis: a randomised controlled trial. Ann Rheum Dis Rheumatology 6 5 Seizures in acute childhood stroke. J Pediatr Neurology 6 5 Point-of-care genetic testing for personalisation of antiplatelet treatment (RAPID GENE): a prospective, randomised, proof-of-concept trial. Lancet Hospital Doctor/Hospitalists 6 6 Internal Medicine 6 6 Cardiology 6 6 Practice, practitioner, or placebo? A multifactorial, mixed-methods randomized controlled trial of acupuncture. Pain Rheumatology 5 4 NMR spectroscopy metabolomic profiling of exhaled breath condensate in patients with stable and unstable cystic fibrosis. Thorax Respirology/Pulmonology 6 6 Effect of lubricating gel on patient comfort during vaginal speculum examination: a randomized controlled trial. Obstet Gynecol General Practice(GP)/Family Practice(FP) 4 4 General Internal Medicine-Primary Care(US) 4 4 Alendronate in the prevention of collapse of the femoral head in non-traumatic osteonecrosis (a randomized, multicenter, double-blind study). Arthritis Rheum Surgery - Orthopaedics 5 4 Rheumatology 4 5 Home versus hospital intravenous antibiotic therapy for cystic fibrosis. Cochrane Database Syst Rev Respirology/Pulmonology 5 5 Infectious Disease 5 4 Hospital Doctor/Hospitalists 4 3 Internal Medicine 4 3 Saccharomyces boulardii for the Prevention of Antibiotic-Associated Diarrhea in Adult Hospitalized Patients: A Single-Center, Randomized, Double-Blind, Placebo-Controlled Trial. Am J Gastroenterol Hospital Doctor/Hospitalists 6 6 Internal Medicine 6 6 Prognostic value of myocardial contrast delayed enhancement with 64-slice multidetector computed tomography after acute myocardial infarction. J Am Coll Cardiol Cardiology 4 4 Effect on Infant Illness of Maternal Supplementation With 400 000 IU Vs 200 000 IU of Vitamin A. Pediatrics Pediatrics (General) 5 4
Article Title Discipline Rele- vance News- worthiness A randomized trial of recombinant human granulocyte-macrophage colony stimulating factor for patients with acute lung injury. Crit Care Med Respirology/Pulmonology 5 5 Intensivist/Critical Care 3 3 Recurrent patellar dislocation in adolescents: medial retinaculum plication versus vastus medialis plasty. Am J Sports Med Surgery - Orthopaedics 6 5 Factors influencing functional outcomes after distal tibia shaft fractures. J Orthop Trauma Surgery - Orthopaedics 7 5 Fibrinogen depleting agents for acute ischaemic stroke. Cochrane Database Syst Rev Neurology 4 4 Discontinuation of hormone replacement therapy after myocardial infarction and short term risk of adverse cardiovascular events: nationwide cohort study. BMJ Cardiology 5 5 Prophylactic versus selective use of surfactant in preventing morbidity and mortality in preterm infants. Cochrane Database Syst Rev Pediatric Neonatology 7 6 Columnar cell lesions on breast needle biopsies: is surgical excision necessary? A systematic review. Ann Surg Oncology - Breast 5 4 Is large birth weight associated with asthma risk in early childhood?. Arch Dis Child General Practice(GP)/Family Practice(FP) 5 4 Allergy and Immunology 4 5 Diagnostics of Femoroacetabular Impingement and Labral Pathology of the Hip: A Systematic Review of the Accuracy and Validity of Physical Tests. Arthroscopy Surgery - Orthopaedics 6 6 A phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP-690,550) versus placebo in combination with background methotrexate in patients with active rheumatoid arthritis and an inadequate response to methotrexate alone. Arthritis Rheum Rheumatology 7 7 Progesterone for premenstrual syndrome. Cochrane Database Syst Rev Gynecology 5 4 A randomized controlled trial of zinc as adjuvant therapy for severe pneumonia in young children. Pediatrics Pediatrics (General) 4 4 Clinic-integrated behavioral intervention for families of youth with type 1 diabetes: randomized clinical trial. Pediatrics General Practice(GP)/Family Practice(FP) 6 5 Oral fluoroquinolones and the risk of retinal detachment. JAMA Infectious Disease 5 6
Article Title Discipline Rele- vance News- worthiness Family-centered program deters substance use, conduct problems, and depressive symptoms in black adolescents. Pediatrics Psychiatry 6 6 Statins for age-related macular degeneration. Cochrane Database Syst Rev Geriatrics 6 4 Intracoronary Abciximab and Aspiration Thrombectomy in Patients With Large Anterior Myocardial Infarction: The INFUSE-AMI Randomized Trial. JAMA Cardiology 6 6 Inositol for respiratory distress syndrome in preterm infants. Cochrane Database Syst Rev Pediatric Neonatology 5 5 Nutrient-enriched formula versus standard term formula for preterm infants following hospital discharge. Cochrane Database Syst Rev Pediatrics (General) 5 6 Closing the gap in postfracture care at the population level: a randomized controlled trial. CMAJ General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Next-generation stool DNA test accurately detects colorectal cancer and large adenomas. Gastroenterology General Practice(GP)/Family Practice(FP) 5 4 General Internal Medicine-Primary Care(US) 5 4 Diagnostic accuracy of computed tomography coronary angiography according to pre-test probability of coronary artery disease and severity of coronary arterial calcification. The CORE-64 (Coronary Artery Evaluation Using 64-Row Multidetector Computed Tomography Angiography) International Multicenter Study. J Am Coll Cardiol Cardiology 6 5 Anti-interleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis. N Engl J Med Dermatology 6 6 Desarda Versus Lichtenstein Technique for Primary Inguinal Hernia Treatment: 3-Year Results of a Randomized Clinical Trial. World J Surg Surgery - General 6 6
Article Title Discipline Rele- vance News- worthiness Wound drains after incisional hernia repair. Cochrane Database Syst Rev Surgery - General 7 4 A Comparative Evaluation of Radiologic and Clinical Scoring Systems in the Early Prediction of Severity in Acute Pancreatitis. Am J Gastroenterol Gastroenterology 5 5 Outcomes of PCI at Hospitals with or without On-Site Cardiac Surgery. N Engl J Med Hospital Doctor/Hospitalists 6 6 Internal Medicine 6 6 Adjuvant radiotherapy for stage I endometrial cancer. Cochrane Database Syst Rev Gynecology 6 5 Honey for acute cough in children. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 6 5 Pediatrics (General) 6 5 Treatment of mild to moderate sinusitis. Arch Intern Med General Practice(GP)/Family Practice(FP) 7 6 General Internal Medicine-Primary Care(US) 7 6 Infectious Disease 6 5 The effect of biological agents on work participation in rheumatoid arthritis patients: a systematic review. Ann Rheum Dis Rheumatology 6 4 Effectiveness of medical nutrition treatment delivered by dietitians on glycaemic outcomes and lipid profiles of Arab, Omani patients with Type 2 diabetes. Diabet Med General Practice(GP)/Family Practice(FP) 4 4 General Internal Medicine-Primary Care(US) 4 4 Exergaming and older adult cognition: a cluster randomized clinical trial. Am J Prev Med General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6 Incidence, predictive factors, and prognostic value of new-onset atrial fibrillation following transcatheter aortic valve implantation. J Am Coll Cardiol Cardiology 6 6 Lifestyle change and mobility in obese adults with type 2 diabetes. N Engl J Med General Practice(GP)/Family Practice(FP) 6 4 General Internal Medicine-Primary Care(US) 6 4 Estimates of early death, acute liver failure, and long-term mortality among live liver donors. Gastroenterology Surgery - General 5 6 Gastroenterology 5 5 Surgery for small asymptomatic abdominal aortic aneurysms. Cochrane Database Syst Rev Surgery - Vascular 6 4
Article Title Discipline Rele- vance News- worthiness Tricyclic antidepressants for autism spectrum disorders (ASD) in children and adolescents. Cochrane Database Syst Rev Psychiatry 5 4 Stretching before sleep reduces the frequency and severity of nocturnal leg cramps in older adults: a randomised trial. J Physiother General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Special Interest - Pain -- Physician 5 6 Single dose oral celecoxib for acute postoperative pain in adults. Cochrane Database Syst Rev Surgery - Orthopaedics 6 4 Adjuvant (post-surgery) chemotherapy for early stage epithelial ovarian cancer. Cochrane Database Syst Rev Oncology - General 6 5 Oncology - Gynecology 6 5 Glutamine supplementation to prevent morbidity and mortality in preterm infants. Cochrane Database Syst Rev Pediatric Neonatology 5 4 Human recombinant activated factor VII for upper gastrointestinal bleeding in patients with liver diseases. Cochrane Database Syst Rev Internal Medicine 5 5 Hematology/Thrombosis 5 5 Higher rates of behavioural and emotional problems at preschool age in children born moderately preterm. Arch Dis Child Pediatrics (General) 7 4 Psychiatry 6 5 General Practice(GP)/Family Practice(FP) 4 4 Screening tools used for measuring depression among people with Type 1 and Type 2 diabetes: a systematic review. Diabet Med Internal Medicine 5 5 Endocrine 5 5 Point-of-care focused cardiac ultrasound for the assessment of thoracic aortic dimensions, dilation, and aneurysmal disease. Acad Emerg Med Cardiology 5 4 Surgery - Vascular 5 4 Managing pulmonary embolism using prognostic models: future concepts for primary care. CMAJ General Practice(GP)/Family Practice(FP) 7 5 General Internal Medicine-Primary Care(US) 7 5 Perioperative methylprednisolone and outcome in neonates undergoing heart surgery. Pediatrics Cardiology 4 4 The effects of continuous positive airway pressure therapy withdrawal on cardiac repolarization: data from a randomized controlled trial. Eur Heart J Respirology/Pulmonology 6 5 Recombinant factor VIIa for the prevention and treatment of bleeding in patients without haemophilia. Cochrane Database Syst Rev Oncology - Hematology 6 6 Surgery - Orthopaedics 3 3
Article Title Discipline Rele- vance News- worthiness Comparison of the yield and miss rate of narrow band imaging and white light endoscopy in patients undergoing screening or surveillance colonoscopy: a meta-analysis. Am J Gastroenterol Gastroenterology 5 5 Memory rehabilitation for people with multiple sclerosis. Cochrane Database Syst Rev Neurology 4 4 Prognostic models for stillbirth and neonatal death in very preterm birth: a validation study. Pediatrics Pediatrics (General) 6 6 GP/FP/Obstetrics 6 5 Pediatric Neonatology 5 5 Direct costs and cost-effectiveness of dual-source computed tomography and invasive coronary angiography in patients with an intermediate pretest likelihood for coronary artery disease. Heart Cardiology 4 5 Antibiotics prior to embryo transfer in ART. Cochrane Database Syst Rev Obstetrics 6 6 Cemented versus uncemented hemiarthroplasty for displaced femoral neck fractures: a prospective randomized trial with early follow-up. J Orthop Trauma Surgery - Orthopaedics 5 6 Garlic for the common cold. Cochrane Database Syst Rev Pediatrics (General) 5 6 General Practice(GP)/Family Practice(FP) 4 3 General Internal Medicine-Primary Care(US) 4 3 Infectious Disease 4 3 Expectant care versus surgical treatment for miscarriage. Cochrane Database Syst Rev GP/FP/Obstetrics 7 4 Obstetrics 6 5 Effect of the human papillomavirus (HPV) quadrivalent vaccine in a subgroup of women with cervical and vulvar disease: retrospective pooled analysis of trial data. BMJ General Practice(GP)/Family Practice(FP) 5 6 General Internal Medicine-Primary Care(US) 5 6 One vs three years of adjuvant imatinib for operable gastrointestinal stromal tumor: a randomized trial. JAMA Surgery - Gastrointestinal 5 5 Bariatric Surgery versus Conventional Medical Therapy for Type 2 Diabetes. N Engl J Med General Practice(GP)/Family Practice(FP) 7 6 General Internal Medicine-Primary Care(US) 7 6 Endocrine 6 4 CT Angiography for Safe Discharge of Patients with Possible Acute Coronary Syndromes. N Engl J Med Emergency Medicine 7 6 Cardiology 5 4 Long-term alcohol consumption in relation to all-cause and cardiovascular mortality among survivors of myocardial infarction: the Health Professionals Follow-up Study. Eur Heart J Cardiology 5 4 General Practice(GP)/Family Practice(FP) 5 3 General Internal Medicine-Primary Care(US) 5 3 Nurse-led care vs. usual care for patients with atrial fibrillation: results of a randomized trial of integrated chronic care vs. routine clinical care in ambulatory patients with atrial fibrillation. Eur Heart J Cardiology 7 6 Hospital Doctor/Hospitalists 6 6 Internal Medicine 6 6 Optimal cut-off score for diagnosing depression with the Patient Health Questionnaire (PHQ-9): a meta-analysis. CMAJ Psychiatry 6 6 General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5
Article Title Discipline Rele- vance News- worthiness Prevention of posttraumatic stress disorder by early treatment: results from the Jerusalem Trauma Outreach And Prevention study. Arch Gen Psychiatry Psychiatry 6 5 Nonoperative versus operative treatment for thoracolumbar burst fractures without neurologic deficit: a meta-analysis. Clin Orthop Relat Res Surgery - Orthopaedics 6 6 Cognitive behavioral therapy for the treatment of juvenile fibromyalgia: a multisite, single-blind, randomized, controlled clinical trial. Arthritis Rheum Rheumatology 6 6 Attention bias modification treatment for pediatric anxiety disorders: a randomized controlled trial. Am J Psychiatry Psychiatry 6 6 Perioperative antibiotics to prevent infection after first-trimester abortion. Cochrane Database Syst Rev Obstetrics 6 6 Gynecology 4 3 Enteral iron supplementation in preterm and low birth weight infants. Cochrane Database Syst Rev Pediatric Neonatology 6 5 A Comparison of Absorbable Screws and Metallic Plates in Treating Calcaneal Fractures: A Prospective Randomized Trial. J Trauma Surgery - Orthopaedics 5 4 Two-Year Outcomes after Transcatheter or Surgical Aortic-Valve Replacement. N Engl J Med Surgery - Cardiac 6 4 Transcatheter Aortic-Valve Replacement for Inoperable Severe Aortic Stenosis. N Engl J Med Surgery - Cardiac 6 5 Acellular vaccines for preventing whooping cough in children. Cochrane Database Syst Rev Pediatrics (General) 7 4 Allergy and Immunology 6 6 General Practice(GP)/Family Practice(FP) 6 5 Vorapaxar in the Secondary Prevention of Atherothrombotic Events. N Engl J Med Cardiology 5 6 Biodegradable polymer drug-eluting stents reduce the risk of stent thrombosis at 4 years in patients undergoing percutaneous coronary intervention: a pooled analysis of individual patient data from the ISAR-TEST 3, ISAR-TEST 4, and LEADERS randomized trials. Eur Heart J Cardiology 6 5 Bariatric Surgery versus Intensive Medical Therapy in Obese Patients with Diabetes. N Engl J Med General Practice(GP)/Family Practice(FP) 7 6 General Internal Medicine-Primary Care(US) 7 6 Internal Medicine 7 6 Endocrine 7 5 Red Blood Cell Transfusion: A Clinical Practice Guideline From the AABB. Ann Intern Med Hematology/Thrombosis 7 6 Hospital Doctor/Hospitalists 7 4 Internal Medicine 7 4 Oral Rivaroxaban for the Treatment of Symptomatic Pulmonary Embolism. N Engl J Med Internal Medicine 7 7 Hematology/Thrombosis 7 6
Article Title Discipline Rele- vance News- worthiness Cost-effectiveness of bivalirudin versus heparin plus glycoprotein IIb/IIIa inhibitor in the treatment of acute ST-segment elevation myocardial infarction. Heart Cardiology 4 4 Improvement of urinary dysfunction after kidney transplantation by administration of the antimuscarinic agent-prospective randomized controlled study. Transplantation Nephrology 6 6 Satavaptan for the management of ascites in cirrhosis: efficacy and safety across the spectrum of ascites severity. Gut Gastroenterology 5 5 Caffeine as an analgesic adjuvant for acute pain in adults. Cochrane Database Syst Rev Neurology 5 5 General Practice(GP)/Family Practice(FP) 4 3 General Internal Medicine-Primary Care(US) 4 3 A randomized trial of long-term remote monitoring of pacemaker recipients (The COMPAS trial). Eur Heart J Cardiology 5 5 Intravenous Dextrose Administration Reduces Postoperative Antiemetic Rescue Treatment Requirements and Postanesthesia Care Unit Length of Stay. Anesth Analg Anesthesiology 6 5 Gynecology 5 4 Bovine lactoferrin prevents invasive fungal infections in very low birth weight infants: a randomized controlled trial. Pediatrics Pediatrics (General) 7 6 Pediatric Neonatology 6 6 Enhancing Care for Hospitalized Older Adults with Cognitive Impairment: A Randomized Controlled Trial. J Gen Intern Med Hospital Doctor/Hospitalists 5 5 Internal Medicine 5 5 Clinical impact of intracoronary abciximab in patients undergoing primary percutaneous coronary intervention: an individual patient data pooled analysis of randomised studies. Heart Cardiology 6 6 Postoperative adjuvant chemotherapy in rectal cancer operated for cure. Cochrane Database Syst Rev Oncology - Gastrointestinal 6 5 Comparison of Dexamethasone with Ondansetron or Haloperidol for Prevention of Patient-Controlled Analgesia-Related Postoperative Nausea and Vomiting: A Randomized Clinical Trial. World J Surg Anesthesiology 6 4 Surgery - Orthopaedics 3 3 Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database Syst Rev Geriatrics 6 5
Article Title Discipline Rele- vance News- worthiness Early diagnosis of acute myocardial infarction in patients with pre-existing coronary artery disease using more sensitive cardiac troponin assays. Eur Heart J Cardiology 5 5 Cyclooxygenase-2 inhibitors and cardiovascular risk in a nation-wide cohort study after the withdrawal of rofecoxib. Eur Heart J Internal Medicine 5 5 Cardiology 5 5 Short- Versus Long-term Duration of Dual Antiplatelet Therapy After Coronary Stenting: A Randomized Multicentre Trial. Circulation Cardiology 7 6 Effectiveness of the LUCAS device for mechanical chest compression after cardiac arrest: systematic review of experimental, observational and animal studies. Heart Emergency Medicine 5 4 Putting the efficacy of psychiatric and general medicine medication into perspective: review of meta-analyses. Br J Psychiatry Psychiatry 6 6 Phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP-690,550) or adalimumab monotherapy versus placebo in patients with active rheumatoid arthritis with an inadequate response to disease-modifying antirheumatic drugs. Arthritis Rheum Rheumatology 7 6 Systematic review of intraoperative cholangiography in cholecystectomy. Br J Surg Surgery - Gastrointestinal 7 5 A Progressive Postresection Walking Program Significantly Improves Fatigue and Health-Related Quality of Life in Pancreas and Periampullary Cancer Patients. J Am Coll Surg Oncology - General 4 4 Oncology - Palliative and Supportive Care 4 4 Evidence-based management of postoperative pain in adults undergoing open inguinal hernia surgery. Br J Surg Anesthesiology 5 4 Surgical treatment with an angular stable plate for complex displaced proximal humeral fractures in elderly patients: a randomized controlled trial. J Orthop Trauma Surgery - Orthopaedics 7 7 A randomized controlled trial of rituximab following failure of antiviral therapy for hepatitis C virus-associated cryoglobulinemic vasculitis. Arthritis Rheum Gastroenterology 5 6 Oxygen Desaturation Index from Nocturnal Oximetry: A Sensitive and Specific Tool to Detect Sleep-Disordered Breathing in Surgical Patients. Anesth Analg Respirology/Pulmonology 5 5 Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials. Lancet Oncology - General 7 6 General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6 Techniques of flushing and reperfusion for liver transplantation. Cochrane Database Syst Rev Surgery - Gastrointestinal 5 4 Airway clearance techniques for chronic obstructive pulmonary disease. Cochrane Database Syst Rev Respirology/Pulmonology 5 5 Oxygen therapy for pneumonia in adults. Cochrane Database Syst Rev Emergency Medicine 6 6 Intensivist/Critical Care 6 5 Operative versus nonoperative treatment of unstable lateral malleolar fractures: a randomized multicenter trial. J Orthop Trauma Surgery - Orthopaedics 6 5 Oral sucrose and ``facilitated tucking`` for repeated pain relief in preterms: a randomized controlled trial. Pediatrics Pediatrics (General) 6 6 Aerobic exercise training during pregnancy reduces depressive symptoms in nulliparous women: a randomised trial. J Physiother GP/FP/Obstetrics 6 4 Gynecology 6 4 General Practice(GP)/Family Practice(FP) 5 4 General Internal Medicine-Primary Care(US) 5 4 Neural tissue management provides immediate clinically relevant benefits without harmful effects for patients with nerve-related neck and arm pain: a randomised trial. J Physiother General Practice(GP)/Family Practice(FP) 5 6 General Internal Medicine-Primary Care(US) 5 6 Central venous access sites for the prevention of venous thrombosis, stenosis and infection. Cochrane Database Syst Rev Hospital Doctor/Hospitalists 6 5 Internal Medicine 6 5 Extended practice and aerobic exercise interventions benefit untrained cognitive outcomes in older adults: a meta-analysis. J Am Geriatr Soc Psychiatry 6 6 Patient education for neck pain. Cochrane Database Syst Rev Special Interest - Pain -- Physician 6 6 Percutaneous endoscopic gastrostomy versus nasogastric tube feeding for adults with swallowing disturbances. Cochrane Database Syst Rev Surgery - General 6 5 Hospital Doctor/Hospitalists 6 4 Internal Medicine 6 4 Gastroenterology 5 3 Regular treatment with formoterol versus regular treatment with salmeterol for chronic asthma: serious adverse events. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 5 4 General Internal Medicine-Primary Care(US) 5 4 Routine preoperative medical testing for cataract surgery. Cochrane Database Syst Rev Anesthesiology 7 6
Article Title Discipline Rele- vance News- worthiness Effectiveness of internet-based cognitive behavioural treatment for adolescents with chronic fatigue syndrome (FITNET): a randomised controlled trial. Lancet Pediatrics (General) 5 6 Ropivacaine continuous wound infusion versus epidural morphine for postoperative analgesia after cesarean delivery: a randomized controlled trial. Anesth Analg Anesthesiology 6 6 Off-pump versus on-pump coronary artery bypass grafting for ischaemic heart disease. Cochrane Database Syst Rev Surgery - Cardiac 6 5 Efficacy of Twice-Daily Rabeprazole for Reflux Esophagitis Patients Refractory to Standard Once-Daily Administration of PPI: The Japan-Based TWICE Study. Am J Gastroenterol General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 Dose response to vitamin d supplementation in postmenopausal women: a randomized trial. Ann Intern Med General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Elevated Risk of Preeclampsia in Pregnant Women With Depression: Depression or Antidepressants?. Am J Epidemiol Obstetrics 6 6 Cardiology 4 5 Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials. Lancet Internal Medicine 7 6 General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 Strict versus liberal target range for perioperative glucose in patients undergoing coronary artery bypass grafting: a prospective randomized controlled trial. J Thorac Cardiovasc Surg Endocrine 6 4 Effect of low-dose human atrial natriuretic peptide on postoperative atrial fibrillation in patients undergoing pulmonary resection for lung cancer: a double-blind, placebo-controlled study. J Thorac Cardiovasc Surg Surgery - Thoracic 5 6 Milnacipran for neuropathic pain and fibromyalgia in adults. Cochrane Database Syst Rev Internal Medicine 5 5 Neurology 5 5 Special Interest - Pain -- Physician 5 3 Identifying community based chronic heart failure patients in the last year of life: a comparison of the Gold Standards Framework Prognostic Indicator Guide and the Seattle Heart Failure Model. Heart Cardiology 5 5 General Practice(GP)/Family Practice(FP) 4 3 General Internal Medicine-Primary Care(US) 4 3 Follow-up for improving psychological well being for women after a miscarriage. Cochrane Database Syst Rev Psychiatry 6 4 GP/FP/Mental Health 4 5 Enhanced Recovery After Surgery (ERAS) program attenuates stress and accelerates recovery in patients after radical resection for colorectal cancer: a prospective randomized controlled trial. World J Surg Surgery - Oncology 6 6 Effect of a Multifaceted Intervention on Use of Evidence-Based Therapies in Patients With Acute Coronary Syndromes in Brazil: The BRIDGE-ACS Randomized Trial. JAMA Hospital Doctor/Hospitalists 6 4 Internal Medicine 6 4 Cardiology 4 4 Chinese medicinal herbs for sore throat. Cochrane Database Syst Rev Pediatrics (General) 5 3 General Practice(GP)/Family Practice(FP) 4 4 General Internal Medicine-Primary Care(US) 4 4
Article Title Discipline Rele- vance News- worthiness Ultrasound and shockwave therapy for acute fractures in adults. Cochrane Database Syst Rev Surgery - Orthopaedics 5 4 The effect of lace-up ankle braces on injury rates in high school football players. Am J Sports Med General Practice(GP)/Family Practice(FP) 5 4 Traumatic patellar dislocation: nonoperative treatment compared with MPFL reconstruction using patellar tendon. Am J Sports Med Physical Medicine and Rehabilitation 5 5 Early neuromuscular electrical stimulation to improve quadriceps muscle strength after total knee arthroplasty: a randomized controlled trial. Phys Ther Surgery - Orthopaedics 5 5 Strategies for improving the acceptability and acceptance of the copper intrauterine device. Cochrane Database Syst Rev Gynecology 4 4 Optimal timing of invasive angiography in stable non-ST-elevation myocardial infarction: the Leipzig Immediate versus early and late PercutaneouS coronary Intervention triAl in NSTEMI (LIPSIA-NSTEMI Trial). Eur Heart J Internal Medicine 6 6 Cardiology 5 5 Investigation of prognostic factors for skin sclerosis and lung function in Japanese patients with early systemic sclerosis: a multicentre prospective observational study. Rheumatology (Oxford) Rheumatology 6 5 Evaluation of treatment effectiveness for the herniated cervical disc: a systematic review. Spine (Phila Pa 1976) Surgery - Orthopaedics 5 4 Rheumatology 5 3 Treatment-resistant and insufficiently treated depression and all-cause mortality following myocardial infarction. Br J Psychiatry Psychiatry 6 4 Effect of peritoneal lavage with clindamycin-gentamicin solution on infections after elective colorectal cancer surgery. J Am Coll Surg Surgery - Colorectal 5 6 Randomized clinical trial of fluid restriction in colorectal surgery. Br J Surg Surgery - Colorectal 6 4 Rilonacept (interleukin-1 trap) in the prevention of acute gout flares during initiation of urate-lowering therapy: Results of a phase II randomized, double-blind, placebo-controlled trial. Arthritis Rheum Rheumatology 6 5 Histamine H2-receptor antagonists for urticaria. Cochrane Database Syst Rev Dermatology 6 5 Stent thrombosis with drug-eluting and bare-metal stents: evidence from a comprehensive network meta-analysis. Lancet Internal Medicine 6 5 Cardiology 5 5
Article Title Discipline Rele- vance News- worthiness Mobile phone text messaging for promoting adherence to antiretroviral therapy in patients with HIV infection. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 5 6 General Internal Medicine-Primary Care(US) 5 6 Mirror therapy for improving motor function after stroke. Cochrane Database Syst Rev Physical Medicine and Rehabilitation 7 6 Neurology 5 5 Outcomes of a Latino Community-Based Intervention for the Prevention of Diabetes: The Lawrence Latino Diabetes Prevention Project. Am J Public Health Endocrine 5 5 Glucose challenge test for detecting gestational diabetes mellitus: a systematic review. BJOG GP/FP/Obstetrics 6 4 Off-pump vs. on-pump coronary artery bypass surgery: an updated meta-analysis and meta-regression of randomized trials. Eur Heart J Surgery - Cardiac 6 5 Is a neutral head position safer than 45-degree neck rotation during ultrasound-guided internal jugular vein cannulation? Results of a randomized controlled clinical trial. Anesth Analg Anesthesiology 6 6 Use of atorvastatin in systemic lupus erythematosus in children and adolescents. Arthritis Rheum Rheumatology 6 6 Performance of HIV-1 DNA or HIV-1 RNA tests for early diagnosis of perinatal HIV-1 infection during anti-retroviral prophylaxis. J Pediatr Pediatric Neonatology 6 6 Effect of biotherapies on fatigue in rheumatoid arthritis: a systematic review of the literature and meta-analysis. Rheumatology (Oxford) Rheumatology 6 5 Blood pressure and heart rate over 10 years in the multimodal treatment study of children with ADHD. Am J Psychiatry Psychiatry 5 5 Remote ischemic preconditioning applied during isoflurane inhalation provides no benefit to the myocardium of patients undergoing on-pump coronary artery bypass graft surgery: lack of synergy or evidence of antagonism in cardioprotection?. Anesthesiology Surgery - Cardiac 5 4 Severity of depression and response to antidepressants: GENPOD randomised controlled trial. Br J Psychiatry GP/FP/Mental Health 6 6 Psychiatry 6 6 General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 Usefulness of anti-p155 autoantibody for diagnosing cancer-associated dermatomyositis: a systematic review and meta-analysis. Arthritis Rheum Rheumatology 6 6 Oncology - General 5 5
Article Title Discipline Rele- vance News- worthiness Topical diltiazem cream versus botulinum toxin a for the treatment of chronic anal fissure: a double-blind randomized clinical trial. Ann Surg Surgery - Colorectal 6 5 Nicotine treatment of mild cognitive impairment: a 6-month double-blind pilot clinical trial. Neurology GP/FP/Mental Health 5 6 Endoscopic transgastric vs surgical necrosectomy for infected necrotizing pancreatitis: a randomized trial. JAMA Gastroenterology 6 5 Surgery - Gastrointestinal 6 5 Morbidity and Mortality Results From a Prospective Randomized Controlled Trial Comparing Billroth I and Roux-en-Y Reconstructive Procedures After Distal Gastrectomy for Gastric Cancer. World J Surg Surgery - Gastrointestinal 6 5 Early versus late tracheostomy for critically ill patients. Cochrane Database Syst Rev Surgery - Head and Neck 6 5 Intensivist/Critical Care 4 4 Medications for increasing milk supply in mothers expressing breastmilk for their preterm hospitalised infants. Cochrane Database Syst Rev Pediatric Neonatology 6 5 Effect of implementation of Integrated Management of Neonatal and Childhood Illness (IMNCI) programme on neonatal and infant mortality: cluster randomised controlled trial. BMJ Pediatrics (General) 6 5 Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials. JAMA Intensivist/Critical Care 6 6 Parental smoking cessation to protect young children: a systematic review and meta-analysis. Pediatrics Public Health 5 5 Meta-analysis of cause of death following total joint replacement using different thromboprophylaxis regimens. J Bone Joint Surg Br Hematology/Thrombosis 5 5 Surgery - Orthopaedics 5 5
Article Title Discipline Rele- vance News- worthiness JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis. N Engl J Med Oncology - General 7 6 Oncology - Hematology 6 6 Laser peripheral iridoplasty for angle-closure. Cochrane Database Syst Rev Surgery - Ophthalmology 6 5 A Randomized Trial With Steroids and Antithymocyte Globulins Comparing Cyclosporine/Azathioprine Versus Tacrolimus/Mycophenolate Mofetil (CATM2) in Renal Transplantation. Transplantation Nephrology 6 4 Can Immune Cell Function Assay Identify Patients at Risk of Infection or Rejection? A Meta-Analysis. Transplantation Surgery - Cardiac 5 4 Magnesium added to bupivacaine prolongs the duration of analgesia after interscalene nerve block. Can J Anaesth GP/FP/Anesthesia 5 5 Evaluation of a peer led parenting intervention for disruptive behaviour problems in children: community based randomised controlled trial. BMJ Pediatrics (General) 6 6 Efficacy of methylprednisolone in preventing lung injury following pulmonary thromboendarterectomy. Chest Surgery - Thoracic 7 5 Respirology/Pulmonology 5 6 Decision support tool for early differential diagnosis of acute lung injury and cardiogenic pulmonary edema in medical critically ill patients. Chest Respirology/Pulmonology 5 5 Diagnostic accuracy of probe-based confocal laser endomicroscopy and narrow band imaging for small colorectal polyps: a feasibility study. Am J Gastroenterol Gastroenterology 5 6 Efficacy of autologous platelet-rich plasma use for orthopaedic indications: a meta-analysis. J Bone Joint Surg Am Surgery - Orthopaedics 6 6 Effects of gut-directed hypnotherapy on IBS in different clinical settings-results from two randomized, controlled trials. Am J Gastroenterol Gastroenterology 6 6 Psychiatry 5 6 The Role of Subacromial Decompression in Patients Undergoing Arthroscopic Repair of Full-Thickness Tears of the Rotator Cuff: A Systematic Review and Meta-Analysis. Arthroscopy Surgery - Orthopaedics 6 5 Human recombinant activated protein C for severe sepsis. Cochrane Database Syst Rev Infectious Disease 6 4 Intensivist/Critical Care 6 3 A randomized trial of tenecteplase versus alteplase for acute ischemic stroke. N Engl J Med Neurology 6 6 Emergency Medicine 6 5
Article Title Discipline Rele- vance News- worthiness Environmental sanitary interventions for preventing active trachoma. Cochrane Database Syst Rev Tropical and Travel Medicine 6 4 A structured protocol of evidence-based conservative care compared with usual care for acute nonspecific low back pain: a randomized clinical trial. Arch Phys Med Rehabil Surgery - Orthopaedics 5 5 The Effect of a Pain Management Program on Patients With Cancer Pain. Cancer Nurs Oncology - Palliative and Supportive Care 6 4 Ingenol mebutate gel for actinic keratosis. N Engl J Med Dermatology 7 5 Remote ischaemic preconditioning reduces myocardial injury in patients undergoing heart valve surgery: randomised controlled trial. Heart Surgery - Cardiac 6 5 Cholinesterase inhibitors for dementia with Lewy bodies, Parkinson`s disease dementia and cognitive impairment in Parkinson`s disease. Cochrane Database Syst Rev Geriatrics 7 5 Prophylactic tricuspid annuloplasty in patients with dilated tricuspid annulus undergoing mitral valve surgery. J Thorac Cardiovasc Surg Surgery - Cardiac 7 4 Esomeprazole compared with famotidine in the prevention of upper gastrointestinal bleeding in patients with acute coronary syndrome or myocardial infarction. Am J Gastroenterol Emergency Medicine 5 4 Hospital Doctor/Hospitalists 5 3 Internal Medicine 5 3 Suicidal Thoughts and Behavior With Antidepressant Treatment: Reanalysis of the Randomized Placebo-Controlled Studies of Fluoxetine and Venlafaxine. Arch Gen Psychiatry General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6 Exercise training improves exercise capacity in adult patients with a systemic right ventricle: a randomized clinical trial. Eur Heart J Cardiology 4 4 Effects of a stepped-care intervention programme among older subjects who screened positive for depressive symptoms in general practice: the PROMODE randomised controlled trial. Age Ageing Psychiatry 6 4 Geriatrics 5 3 Peer mentoring and financial incentives to improve glucose control in african american veterans: a randomized trial. Ann Intern Med General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 Internal Medicine 4 3
Article Title Discipline Rele- vance News- worthiness Influence of access site selection on PCI-related adverse events in patients with STEMI: meta-analysis of randomised controlled trials. Heart Cardiology 5 4 Botulinum toxin for the treatment of strabismus. Cochrane Database Syst Rev Surgery - Ophthalmology 6 5 Skin-derived fibroblasts for the treatment of refractory Achilles tendinosis: preliminary short-term results. J Bone Joint Surg Am Physical Medicine and Rehabilitation 4 6 The comparative effectiveness of combined lumbrical muscle splints and stretches on symptoms and function in carpal tunnel syndrome. Arch Phys Med Rehabil Physical Medicine and Rehabilitation 5 4 Ergocalciferol Supplementation in Children with CKD Delays the Onset of Secondary Hyperparathyroidism: A Randomized Trial. Clin J Am Soc Nephrol Nephrology 6 6 Periarticular Local Anesthesia does not Improve Pain or Mobility after THA. Clin Orthop Relat Res Surgery - Orthopaedics 6 5 Effects of Local Microwave Diathermy on Shoulder Pain and Function in Patients With Rotator Cuff Tendinopathy in Comparison to Subacromial Corticosteroid Injections: A Single Blind Randomized Trial. J Orthop Sports Phys Ther General Practice(GP)/Family Practice(FP) 5 4 General Internal Medicine-Primary Care(US) 5 4 Obesity Treatment for Socioeconomically Disadvantaged Patients in Primary Care Practice. Arch Intern Med Cardiology 5 4 Tracheal intubation through the I-gel supraglottic airway versus the LMA Fastrach: a randomized controlled trial. Anesth Analg Anesthesiology 4 4 Low-Dose Prednisone Inclusion in a Methotrexate-Based, Tight Control Strategy for Early Rheumatoid Arthritis: A Randomized Trial. Ann Intern Med Rheumatology 7 6 Randomized trial to evaluate the efficacy of cognitive therapy for low-functioning patients with schizophrenia. Arch Gen Psychiatry Psychiatry 6 6 The survival of patients with heart failure with preserved or reduced left ventricular ejection fraction: an individual patient data meta-analysis. Eur Heart J General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Effects of Antiplatelet Therapy on Mortality and Cardiovascular and Bleeding Outcomes in Persons With Chronic Kidney Disease: A Systematic Review and Meta-analysis. Ann Intern Med Nephrology 7 6 Cardiology 6 6 Long-Term Efficacy of Dapagliflozin in Patients With Type 2 Diabetes Mellitus Receiving High Doses of Insulin: A Randomized Trial. Ann Intern Med Internal Medicine 6 5 Endocrine 5 4
Article Title Discipline Rele- vance News- worthiness Stem cell treatment for acute myocardial infarction. Cochrane Database Syst Rev Cardiology 6 5 Urinary diversion and bladder reconstruction/replacement using intestinal segments for intractable incontinence or following cystectomy. Cochrane Database Syst Rev Surgery - Urology 6 4 Oncology - Genitourinary 4 3 Pharmacist intervention in primary care to improve outcomes in patients with left ventricular systolic dysfunction. Eur Heart J Cardiology 5 5 The effect of cord cleansing with chlorhexidine on neonatal mortality in rural Bangladesh: a community-based, cluster-randomised trial. Lancet Pediatric Neonatology 5 5 Conventional versus hypofractionated high-dose intensity-modulated radiotherapy for prostate cancer: preliminary safety results from the CHHiP randomised controlled trial. Lancet Oncol Oncology - Genitourinary 5 5 Derivation and Validation of a Prediction Rule for Estimating Advanced Colorectal Neoplasm Risk in Average-Risk Chinese. Am J Epidemiol General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 Glidescope(R) video-laryngoscopy versus direct laryngoscopy for endotracheal intubation: a systematic review and meta-analysis. Can J Anaesth GP/FP/Anesthesia 6 4 Efficacy and safety of paricalcitol therapy for chronic kidney disease: a meta-analysis. Clin J Am Soc Nephrol Nephrology 6 5 Prolonged Versus Standard Duration Venous Thromboprophylaxis in Major Orthopedic Surgery: A Systematic Review. Ann Intern Med Surgery - Orthopaedics 6 4 High-sensitivity C-reactive protein, statin therapy, and risks of atrial fibrillation: an exploratory analysis of the JUPITER trial. Eur Heart J Cardiology 6 6 Role of acute diverticulitis in the development of complicated colonic diverticular disease and 1-year mortality after diagnosis in the UK: population-based cohort study. Gut Gastroenterology 5 5 Fluid resuscitation with 6% hydroxyethyl starch (130/0.4) in acutely ill patients: an updated systematic review and meta-analysis. Anesth Analg Intensivist/Critical Care 6 5 Hospital Doctor/Hospitalists 5 5 Internal Medicine 5 5
Article Title Discipline Rele- vance News- worthiness Pycnogenol((R)) for the treatment of chronic disorders. Cochrane Database Syst Rev Pediatrics (General) 4 4 General Practice(GP)/Family Practice(FP) 3 4 General Internal Medicine-Primary Care(US) 3 4 Cardiology 3 3 Hematology/Thrombosis 3 3 Is physiotherapy effective for children with complex regional pain syndrome type 1?. Clin J Pain Special Interest - Pain -- Physician 6 5 Porcine subintestinal submucosal graft augmentation for rectocele repair: a randomized controlled trial. Obstet Gynecol Surgery - General 6 6 Gynecology 6 5 Urethral injection therapy for urinary incontinence in women. Cochrane Database Syst Rev Gynecology 6 5 External validation of a prognostic model predicting time of death after withdrawal of life support in neurocritical patients. Crit Care Med Intensivist/Critical Care 5 5 The effects of pressure release, phonophoresis of hydrocortisone, and ultrasound on upper trapezius latent myofascial trigger point. . Arch Phys Med Rehabil General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 Rheumatology 5 4 Prior psychiatric hospitalization is associated with excess mortality in patients hospitalized with non-cardiac chest pain: a data linkage study based on the full Scottish population (1991-2006). Eur Heart J Hospital Doctor/Hospitalists 5 5 Internal Medicine 5 5 Increased risk of end-stage renal disease in individuals with coeliac disease. Gut General Practice(GP)/Family Practice(FP) 5 6 General Internal Medicine-Primary Care(US) 5 6 Prognostic Relevance of Integrated Genetic Profiling in Acute Myeloid Leukemia. N Engl J Med Genetics 7 6 Prostate-cancer mortality at 11 years of follow-up. N Engl J Med General Practice(GP)/Family Practice(FP) 7 6 General Internal Medicine-Primary Care(US) 7 6 Oncology - Genitourinary 7 5 Internal Medicine 6 6 Closure or medical therapy for cryptogenic stroke with patent foramen ovale. N Engl J Med Neurology 6 7 Placebo-controlled trial of oral laquinimod for multiple sclerosis. N Engl J Med Neurology 7 6 General Practice(GP)/Family Practice(FP) 5 4 General Internal Medicine-Primary Care(US) 5 4 Epicutaneous allergen-specific immunotherapy ameliorates grass pollen-induced rhinoconjunctivitis: A double-blind, placebo-controlled dose escalation study. J Allergy Clin Immunol Allergy and Immunology 7 7 General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Severity of asthma score predicts clinical outcomes in patients with moderate to severe persistent asthma. Chest General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 Allergy and Immunology 5 3 Risk factors for stroke and thromboembolism in relation to age among patients with atrial fibrillation: the Loire Valley Atrial Fibrillation Project. Chest General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Hematology/Thrombosis 6 5 Internal Medicine 5 4
Article Title Discipline Rele- vance News- worthiness Adoptive immunotherapy for postoperative hepatocellular carcinoma: a systematic review. Int J Clin Pract Oncology - Gastrointestinal 4 4 Safety and immunogenicity of inactivated poliovirus vaccine made from Sabin strains: a phase II, randomized, positive-controlled trial. J Infect Dis Public Health 4 4 Infectious Disease 4 3 A simplified intravenous artesunate regimen for severe malaria. J Infect Dis Pediatric Hospital Medicine 6 6 Long-term results of a randomized, observation-controlled, phase III trial of adjuvant interferon Alfa-2b in hepatocellular carcinoma after curative resection. Ann Surg Surgery - Oncology 5 4 Evaluation of abatacept administered subcutaneously in adults with active rheumatoid arthritis: impact of withdrawal and reintroduction on immunogenicity, efficacy and safety (phase Iiib ALLOW study). Ann Rheum Dis Rheumatology 7 6 Delayed enteral feeding impairs intestinal carbohydrate absorption in critically ill patients. Crit Care Med Intensivist/Critical Care 5 5 Effects of a proximal or distal tibiofibular joint manipulation on ankle range of motion and functional outcomes in individuals with chronic ankle instability. J Orthop Sports Phys Ther Surgery - Orthopaedics 4 4 Physical Medicine and Rehabilitation 4 3 Dutasteride in localised prostate cancer management: the REDEEM randomised, double-blind, placebo-controlled trial. Lancet Oncology - Genitourinary 6 6 Short and long term effects of tibolone in postmenopausal women. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 Active management of the third stage of labour with and without controlled cord traction: a randomised, controlled, non-inferiority trial. Lancet Obstetrics 7 7 GP/FP/Obstetrics 6 5 Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): a randomised, open-label, blinded-endpoints trial. Lancet Pediatrics (General) 5 7 Sustained impact of anticoagulant control achieved in an anticoagulation management service after transfer of management to the primary care physician. Pharmacotherapy Cardiology 4 4 Hematology/Thrombosis 3 3 Pain Management by Periarticular Multimodal Drug Injection After Anterior Cruciate Ligament Reconstruction: A Randomized, Controlled Study. Arthroscopy Anesthesiology 6 6 Mortality in Kidney Disease Patients Treated with Phosphate Binders: A Randomized Study. Clin J Am Soc Nephrol Nephrology 6 6 Noncardiac vascular disease in rheumatoid arthritis: increase in venous thromboembolic events?. Arthritis Rheum General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 Economic evaluation of chlorhexidine-impregnated sponges for preventing catheter-related infections in critically ill adults in the Dressing Study. Crit Care Med Infectious Disease 7 6 Differential risk of death in older residents in nursing homes prescribed specific antipsychotic drugs: population based cohort study. BMJ Geriatrics 7 5
Article Title Discipline Rele- vance News- worthiness The CONECSI trial: results of a randomized controlled trial of a multidisciplinary cognitive behavioral program for coping with chronic neuropathic pain after spinal cord injury. Pain Special Interest - Pain -- Physician 5 4 Chest physiotherapy for acute bronchiolitis in paediatric patients between 0 and 24 months old. Cochrane Database Syst Rev Respirology/Pulmonology 6 4 Pediatric Emergency Medicine 6 4 A practical molecular assay to predict survival in resected non-squamous, non-small-cell lung cancer: development and international validation studies. Lancet Oncology - Lung 7 6 Fluticasone furoate demonstrates efficacy in patients with asthma symptomatic on medium doses of inhaled corticosteroid therapy: an 8-week, randomised, placebo-controlled trial. Thorax Respirology/Pulmonology 5 4 The Eldicus prospective, observational study of triage decision making in European intensive care units: part I--European Intensive Care Admission Triage Scores. Crit Care Med Intensivist/Critical Care 6 6 Complications of first-trimester abortion by vacuum aspiration after cervical preparation with and without misoprostol: a multicentre randomised trial. Lancet Obstetrics 6 5 Dyspnoea severity and pneumonia as predictors of in-hospital mortality and early readmission in acute exacerbations of COPD. Thorax Hospital Doctor/Hospitalists 6 5 Internal Medicine 6 5 A randomized controlled trial to investigate the effects of water-based exercise to improve falls risk and physical function in older adults with lower-extremity osteoarthritis. Arch Phys Med Rehabil Geriatrics 6 4 A Randomized Controlled Trial of Intravenous or Oral Iron for Posttransplant Anemia in Kidney Transplantation. Transplantation Nephrology 6 5 Efficacy of Directional Preference Management for Low Back Pain: A Systematic Review. Phys Ther General Practice(GP)/Family Practice(FP) 5 4 General Internal Medicine-Primary Care(US) 5 4 The Efficacy of Acromioplasty in the Arthroscopic Repair of Small- to Medium-Sized Rotator Cuff Tears Without Acromial Spur: Prospective Comparative Study. Arthroscopy Surgery - Orthopaedics 6 6 Which is the Best Alternative for Displaced Femoral Neck Fractures in the Elderly?: A Meta-Analysis. Clin Orthop Relat Res Surgery - Orthopaedics 7 6 Dipeptidyl peptidase-4 inhibitors for treatment of type 2 diabetes mellitus in the clinical setting: systematic review and meta-analysis. BMJ Hospital Doctor/Hospitalists 6 6 Internal Medicine 6 6 Efficacy of oral vs. topical, or combined oral and topical 5-aminosalicylates, in Ulcerative Colitis: systematic review and meta-analysis. Am J Gastroenterol General Practice(GP)/Family Practice(FP) 5 6 General Internal Medicine-Primary Care(US) 5 6
Article Title Discipline Rele- vance News- worthiness Comparison of two dosing frequencies of subcutaneous interferon beta-1a in patients with a first clinical demyelinating event suggestive of multiple sclerosis (REFLEX): a phase 3 randomised controlled trial. Lancet Neurol Neurology 6 5 Prospective randomized phase II Trial of accelerated reepithelialization of superficial second-degree burn wounds using extracorporeal shock wave therapy. Ann Surg Surgery - Plastic 6 5 Topical application of chlorhexidine to neonatal umbilical cords for prevention of omphalitis and neonatal mortality in a rural district of Pakistan: a community-based, cluster-randomised trial. Lancet Pediatric Neonatology 6 5 Effect of a cash transfer programme for schooling on prevalence of HIV and herpes simplex type 2 in Malawi: a cluster randomised trial. Lancet Public Health 6 5 Can Supervised Group Exercises Including Ergonomic Advice Reduce the Prevalence and Severity of Low Back Pain and Pelvic Girdle Pain in Pregnancy? A Randomized Controlled Trial. Phys Ther GP/FP/Obstetrics 5 5 Obstetrics 5 4 A systematic review of the evidence for pharmacist care of patients with dyslipidemia. Pharmacotherapy Cardiology 6 5 General Practice(GP)/Family Practice(FP) 3 4 General Internal Medicine-Primary Care(US) 3 4 Long-Term Kidney Allograft Function and Survival in Prednisone-Free Regimens: Tacrolimus/Mycophenolate Mofetil versus Tacrolimus/Sirolimus. Clin J Am Soc Nephrol Surgery - Urology 5 5 Depression in older people in the general hospital: a systematic review of screening instruments. Age Ageing Geriatrics 7 5 Hospital Doctor/Hospitalists 6 5 Internal Medicine 6 5 Oral Direct Factor Xa Inhibitors Versus Low-Molecular-Weight Heparin to Prevent Venous Thromboembolism in Patients Undergoing Total Hip or Knee Replacement: A Systematic Review and Meta-analysis. Ann Intern Med Hematology/Thrombosis 6 6
Article Title Discipline Rele- vance News- worthiness Burn size and survival probability in paediatric patients in modern burn care: a prospective observational cohort study. Lancet Pediatric Hospital Medicine 6 5 Evaluating the evidence for the implementation of C-reactive protein measurement in adult patients with suspected lower respiratory tract infection in primary care: a systematic review. Fam Pract Infectious Disease 6 4 Internal Medicine 5 5 General Practice(GP)/Family Practice(FP) 4 5 General Internal Medicine-Primary Care(US) 4 5 Clinical and economic burden of community-acquired pneumonia among adults in Europe. Thorax Infectious Disease 5 4 Early surgical therapy for drug-resistant temporal lobe epilepsy: a randomized trial. JAMA Neurology 7 6 Human rhinoviruses in severe respiratory disease in very low birth weight infants. Pediatrics Respirology/Pulmonology 6 6 Cost-Effectiveness of Transcatheter Aortic Valve Replacement Compared With Standard Care Among Inoperable Patients With Severe Aortic Stenosis: Results From the Placement of Aortic Transcatheter Valves (PARTNER) Trial (Cohort B). Circulation Surgery - Cardiac 7 7 Peer-led education for adolescents with asthma in Jordan: a cluster-randomized controlled trial. Pediatrics Allergy and Immunology 5 5 Participation and yield of colonoscopy versus non-cathartic CT colonography in population-based screening for colorectal cancer: a randomised controlled trial. Lancet Oncol Gastroenterology 7 7 General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6 Overall efficacy of HPV-16/18 AS04-adjuvanted vaccine against grade 3 or greater cervical intraepithelial neoplasia: 4-year end-of-study analysis of the randomised, double-blind PATRICIA trial. Lancet Oncol Gynecology 6 6 Public Health 6 6 Infectious Disease 6 5 General Practice(GP)/Family Practice(FP) 5 4 General Internal Medicine-Primary Care(US) 5 4 Randomized clinical trial for apogeotropic horizontal canal benign paroxysmal positional vertigo. Neurology General Practice(GP)/Family Practice(FP) 7 6 General Internal Medicine-Primary Care(US) 7 6 Emergency Medicine 5 6
Article Title Discipline Rele- vance News- worthiness Greater satisfaction in older patients with a mobile-bearing compared with fixed-bearing total knee arthroplasty. J Arthroplasty Surgery - Orthopaedics 5 4 Prolonged strength training in older patients after hip fracture: a randomised controlled trial. Age Ageing Geriatrics 6 4 Efficacy and safety of dalcetrapib in type 2 diabetes mellitus and/or metabolic syndrome patients, at high cardiovascular disease risk. Diabetes Obes Metab Endocrine 5 6 A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis. N Engl J Med Oncology - Hematology 6 7 Cancer genetic risk assessment for individuals at risk of familial breast cancer. Cochrane Database Syst Rev Oncology - Breast 5 5 Oral contraceptives containing drospirenone for premenstrual syndrome. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 6 4 Non surgical therapy for anal fissure. Cochrane Database Syst Rev Surgery - General 6 6 Gastroenterology 6 5 General Practice(GP)/Family Practice(FP) 6 4 General Internal Medicine-Primary Care(US) 6 4 Use of cystatin C levels in estimating renal function and prognosis in patients with chronic systolic heart failure. Heart Cardiology 5 5 Bisphosphonates and other bone agents for breast cancer. Cochrane Database Syst Rev Oncology - Breast 6 4 A nationwide cohort study on the incidence of meningioma in women using postmenopausal hormone therapy in Finland. Am J Epidemiol Gynecology 6 6 Meta-analysis of individual patient data in randomised trials of self monitoring of blood glucose in people with non-insulin treated type 2 diabetes. BMJ Internal Medicine 6 6 General Practice(GP)/Family Practice(FP) 6 4 General Internal Medicine-Primary Care(US) 6 4 Diagnostic and prognostic impact of copeptin and high-sensitivity cardiac troponin T in patients with pre-existing coronary artery disease and suspected acute myocardial infarction. Heart Emergency Medicine 6 6 Cardiology 4 4 Aerobic capacity and exercise performance in young people born extremely preterm. Pediatrics Pediatric Neonatology 5 6 Respirology/Pulmonology 5 5 Donepezil and memantine for moderate-to-severe Alzheimer`s disease. N Engl J Med General Internal Medicine-Primary Care(US) 6 6 Hospital Doctor/Hospitalists 6 6 Internal Medicine 6 6 Geriatrics 6 6 General Practice(GP)/Family Practice(FP) 6 6 GP/FP/Mental Health 6 5 Neurology 6 5 Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): a randomised multicentre, open-label, phase 2 trial. Lancet Oncol Oncology - Breast 6 6
Article Title Discipline Rele- vance News- worthiness Initial trophic vs full enteral feeding in patients with acute lung injury: the EDEN randomized trial. JAMA Intensivist/Critical Care 6 5 External Fixation versus Internal Fixation for Unstable Distal Radius Fractures: A Systematic Review and Meta-Analysis of Comparative Clinical Trials. J Orthop Trauma Surgery - Orthopaedics 6 5 A randomized controlled trial of positive-affect intervention and medication adherence in hypertensive African Americans. Arch Intern Med General Practice(GP)/Family Practice(FP) 5 6 General Internal Medicine-Primary Care(US) 5 6 Laparoscopic entry techniques. Cochrane Database Syst Rev Gynecology 5 4 Hepatitis B virus coinfection negatively impacts HIV outcomes in HIV seroconverters. J Infect Dis Gastroenterology 6 5 Infectious Disease 6 5 ST analysis of the fetal electrocardiogram in intrapartum fetal monitoring: a meta-analysis. Obstet Gynecol GP/FP/Obstetrics 6 6 Cardiovascular disease in kidney donors: matched cohort study. BMJ Nephrology 6 5 Comparison of diagnostic criteria to detect undiagnosed diabetes in hyperglycaemic patients with acute coronary syndrome. Heart Cardiology 5 4 Effect of specific exercise strategy on need for surgery in patients with subacromial impingement syndrome: randomised controlled study. BMJ Physical Medicine and Rehabilitation 7 6 Stapled versus handsewn methods for colorectal anastomosis surgery. Cochrane Database Syst Rev Surgery - Colorectal 6 4 Surgery - Gastrointestinal 5 4 Non-steroidal anti-inflammatory agents for treating cystoid macular oedema following cataract surgery. Cochrane Database Syst Rev Surgery - Ophthalmology 5 4 Corticosteroid pulse combination therapy for refractory Kawasaki disease: a randomized trial. Pediatrics Pediatrics (General) 5 5 Sumatriptan (subcutaneous route of administration) for acute migraine attacks in adults. Cochrane Database Syst Rev Neurology 7 5 Special Interest - Pain -- Physician 6 4 Water for wound cleansing. Cochrane Database Syst Rev Obstetrics 5 4 Association of Repeated Exposure to Antibiotics With the Development of Pediatric Crohn`s Disease--A Nationwide, Register-based Finnish Case-Control Study. Am J Epidemiol Pediatrics (General) 6 6 Comparison of the Framingham and Reynolds Risk Scores for Global Cardiovascular Risk Prediction in the Multiethnic Women`s Health Initiative. Circulation General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Cardiology 5 5
Article Title Discipline Rele- vance News- worthiness Over-the-counter (OTC) medications to reduce cough as an adjunct to antibiotics for acute pneumonia in children and adults. Cochrane Database Syst Rev Pediatrics (General) 6 4 General Practice(GP)/Family Practice(FP) 5 4 General Internal Medicine-Primary Care(US) 5 4 Randomized trial of type 1 and type 3 oral monovalent poliovirus vaccines in newborns in Africa. J Infect Dis Infectious Disease 5 4 The economic and clinical benefits of adequate insulin initiation and intensification in people with type 2 diabetes mellitus. Diabetes Obes Metab Internal Medicine 5 3 Endocrine 4 4 Quality of life after laparoscopic and abdominal hysterectomy: a randomized controlled trial. Obstet Gynecol Gynecology 6 5 Placebo-controlled trial of amantadine for severe traumatic brain injury. N Engl J Med Surgery - Neurosurgery 5 4 An online self-help CBT intervention for chronic lower back pain. Clin J Pain Psychiatry 6 6 Special Interest - Pain -- Physician 6 6 GP/FP/Mental Health 4 3 Elective high-frequency oscillatory versus conventional ventilation in preterm infants: a systematic review and meta-analysis of individual patients` data. Lancet Pediatric Neonatology 6 5 Effects of early pelvic-floor muscle exercise for sexual dysfunction in radical prostatectomy recipients. Cancer Nurs Oncology - Genitourinary 5 4 Effects of motivational interviewing intervention on self-management, psychological and glycemic outcomes in type 2 diabetes: A randomized controlled trial. Int J Nurs Stud General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Endocrine 5 5 Antipsychotic drug treatment for elderly people with late-onset schizophrenia. Cochrane Database Syst Rev Geriatrics 6 4 Psychiatry 4 3 Growth hormone for children with chronic kidney disease. Cochrane Database Syst Rev Nephrology 6 4 Effects of age on long-term outcomes after a routine invasive or selective invasive strategy in patients presenting with non-ST segment elevation acute coronary syndromes: a collaborative analysis of individual data from the FRISC II - ICTUS - RITA-3 (FIR) trials. Heart Cardiology 5 4 Predictors of Long-Term Survival Following Coronary Artery Bypass Grafting Surgery: Results from The Society of Thoracic Surgeons Adult Cardiac Surgery Database (The ASCERT Study). Circulation Cardiology 7 6 Vaccines for preventing rotavirus diarrhoea: vaccines in use. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 6 4
Article Title Discipline Rele- vance News- worthiness Prevention of lymphocele in female pelvic lymphadenectomy by a collagen patch coated with the human coagulation factors: A pilot study. J Surg Oncol Surgery - Oncology 5 5 Antibiotic prophylaxis for hernia repair. Cochrane Database Syst Rev Infectious Disease 6 4 Active Surveillance in Men With Localized Prostate Cancer: A Systematic Review. Ann Intern Med Surgery - Urology 7 4 Effectiveness of heart failure management programmes with nurse-led discharge planning in reducing re-admissions: A systematic review and meta-analysis. Int J Nurs Stud Hospital Doctor/Hospitalists 6 4 Internal Medicine 6 4 TAK-875 versus placebo or glimepiride in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial. Lancet Internal Medicine 5 5 General Practice(GP)/Family Practice(FP) 3 3 General Internal Medicine-Primary Care(US) 3 3 Intracoronary versus intravenous bolus abciximab during primary percutaneous coronary intervention in patients with acute ST-elevation myocardial infarction: a randomised trial. Lancet Cardiology 5 5 Prediction of Long Term Mortality after Percutaneous Coronary Intervention in Older Adults: Results from the National Cardiovascular Data Registry. Circulation Cardiology 5 4 Evolution of disease burden over five years in a multicenter inception systemic lupus erythematosus cohort. Arthritis Care Res (Hoboken) Rheumatology 5 5 Early intervention improves behavioral outcomes for preterm infants: randomized controlled trial. Pediatrics Pediatrics (General) 6 5 Validation of a clinical prediction rule to distinguish Lyme meningitis from aseptic meningitis. Pediatrics Emergency Medicine 5 4 Once-daily versus multiple-daily dosing with intravenous aminoglycosides for cystic fibrosis. Cochrane Database Syst Rev Respirology/Pulmonology 6 5 Fluids and diuretics for acute ureteric colic. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 Emergency Medicine 5 4
Article Title Discipline Rele- vance News- worthiness Synthetic conjugated estrogens-B and postmenopausal nocturnal vasomotor symptoms: a randomized controlled trial. Obstet Gynecol General Practice(GP)/Family Practice(FP) 5 4 General Internal Medicine-Primary Care(US) 5 4 A randomized trial of nicotine-replacement therapy patches in pregnancy. N Engl J Med Obstetrics 6 5 Does Ramosetron Reduce Postoperative Emesis and Pain after TKA?. Clin Orthop Relat Res Anesthesiology 6 5 Granulocyte colony stimulating factor in chronic angina to stimulate neovascularisation: a placebo controlled crossover trial. Heart Cardiology 5 4 Association of Proton Pump Inhibitor Use on Cardiovascular Outcomes With Clopidogrel and Ticagrelor: Insights From the Platelet Inhibition and Patient Outcomes Trial. Circulation Internal Medicine 5 5 Cardiology 5 5 Corticosteroid after etomidate in critically ill patients: a randomized controlled trial. Crit Care Med Emergency Medicine 6 6 Rehabilitation after myocardial infarction trial (RAMIT): multi-centre randomised controlled trial of comprehensive cardiac rehabilitation in patients following acute myocardial infarction. Heart Hospital Doctor/Hospitalists 6 6 Internal Medicine 6 6 Cardiology 6 5
Article Title Discipline Rele- vance News- worthiness Aggression and seclusion on acute psychiatric wards: effect of short-term risk assessment. Br J Psychiatry Psychiatry 7 5 Impact of body mass index on survival after colorectal cancer diagnosis: the Cancer Prevention Study-II Nutrition Cohort. J Clin Oncol Oncology - Gastrointestinal 6 4 Preventing progression to first-episode psychosis in early initial prodromal states. Br J Psychiatry Psychiatry 7 6 Pyridorin in type 2 diabetic nephropathy. J Am Soc Nephrol Nephrology 6 6 Endocrine 5 4 A randomized controlled trial of positive-affect induction to promote physical activity after percutaneous coronary intervention. Arch Intern Med Hospital Doctor/Hospitalists 4 4 Internal Medicine 4 4 Whole-body vibration training for patients with neurodegenerative disease. Cochrane Database Syst Rev Neurology 4 4 Regular exercise during pregnancy to prevent gestational diabetes: a randomized controlled trial. Obstet Gynecol General Practice(GP)/Family Practice(FP) 5 6 General Internal Medicine-Primary Care(US) 5 6 Novel serum and urine markers for pediatric appendicitis. Acad Emerg Med Surgery - General 5 6 The Lively Legs self-management programme increased physical activity and reduced wound days in leg ulcer patients: Results from a randomized controlled trial. Int J Nurs Stud General Practice(GP)/Family Practice(FP) 5 4 General Internal Medicine-Primary Care(US) 5 4 Vaccines for measles, mumps and rubella in children. Cochrane Database Syst Rev Pediatrics (General) 6 5
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Article Title Discipline Rele- vance News- worthiness Factors associated with virological failure in HIV-1-infected patients receiving darunavir/ritonavir monotherapy. J Infect Dis Infectious Disease 6 5 Three-dimensional component alignment and functional outcome in computer-navigated total knee arthroplasty a prospective, randomized study comparing two navigation systems. J Arthroplasty Surgery - Orthopaedics 4 5 Simultaneous cemented and cementless total knee replacement in the same patients: a prospective comparison of long-term outcomes using an identical design of NexGen prosthesis. J Bone Joint Surg Br Surgery - Orthopaedics 5 5 Prospective molecular marker analyses of EGFR and KRAS from a randomized, placebo-controlled study of erlotinib maintenance therapy in advanced non-small-cell lung cancer. J Clin Oncol Oncology - Lung 6 6 Home-based child development interventions for preschool children from socially disadvantaged families. Cochrane Database Syst Rev Pediatrics (General) 6 4 Information interventions for orienting patients and their carers to cancer care facilities. Cochrane Database Syst Rev Oncology - Breast 5 4 Oncology - Genitourinary 4 3 Antiemetics: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol Oncology - General 6 4 Liberal or Restrictive Transfusion in High-Risk Patients after Hip Surgery. N Engl J Med Cardiology 6 6 Hematology/Thrombosis 6 4 Comparison of three predictive rules for assessing severity in elderly patients with CAP. Int J Clin Pract General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Hospital Doctor/Hospitalists 6 5 Internal Medicine 6 5 Infectious Disease 6 5
Article Title Discipline Rele- vance News- worthiness Multimodal nutritional rehabilitation improves clinical outcomes of malnourished patients with chronic respiratory failure: a randomised controlled trial. Thorax Respirology/Pulmonology 6 5 Energy-based vessel sealing in vaginal hysterectomy: a systematic review and meta-analysis. Obstet Gynecol Gynecology 5 5 Effect of regional anesthesia on the success rate of external cephalic version: a systematic review and meta-analysis. Obstet Gynecol GP/FP/Obstetrics 6 5 Eslicarbazepine acetate add-on for drug-resistant partial epilepsy. Cochrane Database Syst Rev Neurology 6 5 Relaxation techniques for pain management in labour. Cochrane Database Syst Rev Obstetrics 6 5 Age and risks of FDA-approved long-acting beta-adrenergic receptor agonists. Pediatrics General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6 Are there better guidelines for allocation in liver transplantation? A novel score targeting justice and utility in the model for end-stage liver disease era. Ann Surg Gastroenterology 5 5 Intensive diabetes therapy and glomerular filtration rate in type 1 diabetes. N Engl J Med Internal Medicine 6 5 Randomized, double-blind, placebo-controlled phase II study of single-agent oral talactoferrin in patients with locally advanced or metastatic non-small-cell lung cancer that progressed after chemotherapy. J Clin Oncol Oncology - Lung 5 6 Hormone replacement for osteoporosis in women with primary biliary cirrhosis. Cochrane Database Syst Rev Gastroenterology 5 5 The association of Framingham and Reynolds risk scores with incidence and progression of coronary artery calcification in MESA (Multi-Ethnic Study of Atherosclerosis). J Am Coll Cardiol Cardiology 5 5 Low-molecular-weight heparin and mortality in acutely ill medical patients. N Engl J Med Hospital Doctor/Hospitalists 7 6 Internal Medicine 7 6 Hematology/Thrombosis 7 6 CYP2C19 genotype, clopidogrel metabolism, platelet function, and cardiovascular events: a systematic review and meta-analysis. JAMA Hospital Doctor/Hospitalists 5 5 Internal Medicine 5 5 CHADS(2) and CHA(2)DS(2)-VASc Scores in the Prediction of Clinical Outcomes in Patients With Atrial Fibrillation After Catheter Ablation. J Am Coll Cardiol Cardiology 6 5
Article Title Discipline Rele- vance News- worthiness Vertical Versus Horizontal Suture Configuration for the Repair of Isolated Type II SLAP Lesion Through a Single Anterior Portal: A Randomized Controlled Trial. Arthroscopy Surgery - Orthopaedics 5 4 Continuous Control of Tracheal Cuff Pressure and Microaspiration of Gastric Contents in Critically Ill Patients. Am J Respir Crit Care Med Respirology/Pulmonology 6 4 Sustained disease remission and inhibition of radiographic progression in methotrexate-naive patients with rheumatoid arthritis and poor prognostic factors treated with abatacept: 2-year outcomes. Ann Rheum Dis Rheumatology 6 5 Behavioral interventions to reduce the transmission of HIV infection among sex workers and their clients in high-income countries. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 Infectious Disease 4 3 Public Health 4 3 Symptomatic effects of chondroitin 4 and chondroitin 6 sulfate on hand osteoarthritis: a randomized, double-blind, placebo-controlled clinical trial at a single center. Arthritis Rheum Rheumatology 6 6 Hypotonic versus isotonic maintenance fluids after surgery for children: a randomized controlled trial. Pediatrics Surgery - General 7 6 Changing long-term outcomes for infants 500-999 g birth weight in Victoria, 1979-2005. Arch Dis Child Fetal Neonatal Ed Pediatric Neonatology 6 5 Social skills training for Attention Deficit Hyperactivity Disorder (ADHD) in children aged 5 to 18 years. Cochrane Database Syst Rev Psychiatry 6 5 Effect of neuromuscular warm-up on injuries in female soccer and basketball athletes in urban public high schools: cluster randomized controlled trial. Arch Pediatr Adolesc Med Pediatrics (General) 6 4 Effect of bariatric surgery on cardiovascular risk profile. Am J Cardiol Cardiology 5 5 Central obesity and cardiovascular outcomes in patients with acute coronary syndrome: observations from the MERLIN-TIMI 36 trial. Heart Endocrine 5 5 Association between chlorthalidone treatment of systolic hypertension and long-term survival. JAMA General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Internal Medicine 6 5 Cardiology 6 5
Article Title Discipline Rele- vance News- worthiness Using a Montessori method to increase eating ability for institutionalised residents with dementia: a crossover design. J Clin Nurs Geriatrics 6 4 Characterization and outcomes of young infants with acute liver failure. J Pediatr Pediatric Neonatology 6 5 Prospective, Randomized Study Between Insall-Burstein II and NexGen Legacy with a Minimum 9-Year Follow-Up. J Arthroplasty Surgery - Orthopaedics 5 4 Diagnosis of ischemia-causing coronary stenoses by noninvasive fractional flow reserve computed from coronary computed tomographic angiograms. Results from the prospective multicenter DISCOVER-FLOW (Diagnosis of Ischemia-Causing Stenoses Obtained Via Noninvasive Fractional Flow Reserve) study. J Am Coll Cardiol Cardiology 6 6
Article Title Discipline Rele- vance News- worthiness Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: a randomized, double-blind, placebo-controlled phase III study. J Clin Oncol Oncology - Gastrointestinal 5 5 Maternal cardiac output changes after crystalloid or colloid coload following spinal anesthesia for elective cesarean delivery: a randomized controlled trial. Anesth Analg Anesthesiology 6 6 Comparison between closed suction drainage and nondrainage in total knee arthroplasty a meta-analysis. J Arthroplasty Surgery - Orthopaedics 6 5 Anterolateral minimally invasive total hip arthroplasty a prospective randomized controlled study with a follow-up of 1 year. J Arthroplasty Surgery - Orthopaedics 6 5 Efficacy and safety of alogliptin added to pioglitazone in Japanese patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial with an open-label long-term extension study. Diabetes Obes Metab Internal Medicine 6 5 Endocrine 5 3 CPAP for the metabolic syndrome in patients with obstructive sleep apnea. N Engl J Med Respirology/Pulmonology 6 6 Dabigatran vs. placebo in patients with acute coronary syndromes on dual antiplatelet therapy: a randomized, double-blind, phase II trial. Eur Heart J Hematology/Thrombosis 6 6
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Article Title Discipline Rele- vance News- worthiness Interventions to reduce haemorrhage during myomectomy for fibroids. Cochrane Database Syst Rev Gynecology 5 5 Response of unexplained chest pain to proton pump inhibitor treatment in patients with and without objective evidence of gastro-oesophageal reflux disease. Gut Gastroenterology 6 5 Comparison of different approaches to confounding adjustment in a study on the association of antipsychotic medication with mortality in older nursing home patients. Am J Epidemiol Psychiatry 5 4 Interferon alpha for chronic hepatitis D. Cochrane Database Syst Rev Internal Medicine 6 6 Novel Probe-Based Confocal Laser Endomicroscopy Criteria and Interobserver Agreement for the Detection of Dysplasia in Barrett`s Esophagus. Am J Gastroenterol Gastroenterology 6 5 Meningiomas in children and adolescents: a meta-analysis of individual patient data. Lancet Oncol Surgery - Neurosurgery 6 5 Comparisons of approaches to pelvic floor muscle training for urinary incontinence in women. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 5 4 General Internal Medicine-Primary Care(US) 5 4 Geriatrics 5 3 Early additional food and fluids for healthy breastfed full-term infants. Cochrane Database Syst Rev Pediatric Neonatology 5 4 Light-emitting diode phototherapy for unconjugated hyperbilirubinaemia in neonates. Cochrane Database Syst Rev Pediatric Neonatology 6 6 Safety and immunogenicity of live attenuated and inactivated influenza vaccines in children with cancer. J Infect Dis Pediatrics (General) 6 5
1 被引用Citations: 12,872次 Title: ANALYSIS OF RELATIVE GENE EXPRESSION DATA USING REAL-TIME QUANTITATIVE PCR AND THE 2(T)(-DELTA DELTA C) METHOD Authors: LIVAK KJ; SCHMITTGEN TD Source: METHODS 25 (4): 402-408 DEC 2001 Addresses: Washington State Univ, Dept Pharmaceut Sci, Pullman, WA 99164 USA. Appl Biosyst Inc, Foster City, CA 94404 USA. Field: BIOLOGY BIOCHEMISTRY 此文献在各个引文数据库中的引用量 至2011年12月29日,此文献在 Web of Knowledge 中 已被引用 15,110 次 14,062 次 检索范围 Web of Science 14,002次 检索范围 Science Citation Index Expanded (SCIE), Social Science Citation Index (SSCI), 至 Arts Humanities Citation Index (AHCI) 14,002 检索范围 Science Citation Index Expanded (SCIE) 36 检索范围 Social Science Citation Index (SSCI) 0 检索范围 Arts Humanities Citation Index (AHCI) 220次 检索范围 Conference Proceedings Citation Index - Science (CPCI-S);Conference Proceedings Citation Index - Social Science Humanities (CPCI-SSH) 220 检索范围 Conference Proceedings Citation Index - Science (CPCI-S) 2 检索范围 Conference Proceedings Citation Index - Social Science Humanities (CPCI-SSH) 62次 检索范围 Book Citation Index– Science(BKCI-S); Book Citation Index– Social Sciences Humanities(BKCI-SSH) 62 检索范围 Book Citation Index– Science(BKCI-S) 0 检索范围 Book Citation Index– Social Sciences Humanities(BKCI-SSH) 12,853次 检索范围 BIOSIS Citation Index 996次 检索范围 中国科学引文数据库 http://apps.webofknowledge.com/InboundService.do?UT=000173949500003IsProductCode=Yesmode=FullRecordproduct=WOSSID=U294fMdF6lE35oGj696returnLink=http%3A%2F%2Fesi.webofknowledge.com%2Fpaperpage.cgi%3Foption%3DG%26option%3DG%26searchby%3DF%26search%3D%2528All%2520Fields%2529%26hothigh%3DG%26x%3D18%26y%3D9srcDesc=RET2ESISrcApp=CRDestFail=http%3A%2F%2Fwww.webofknowledge.comaction=retrieveInit=YescustomersID=ESIFunc=Frame 原文获取: http://www.sciencedirect.com/science/article/pii/S1046202301912629 2 被引用Citations: 12,649 次 Title: A SHORT HISTORY OF SHELX Authors: SHELDRICK GM Source: ACTA CRYSTALLOGR A 64: 112-122 Part 1 JAN 2008 Addresses: Univ Gottingen, Dept Struct Chem, Tammann Str 4, D-37077 Gottingen, Germany. Univ Gottingen, Dept Struct Chem, D-37077 Gottingen, Germany. Field: CHEMISTRY
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Article Title Discipline Rele- vance News- worthiness Treatment of polycythemia vera with hydroxyurea and pipobroman: final results of a randomized trial initiated in 1980. J Clin Oncol Oncology - Hematology 7 7 Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial. Lancet Nephrology 5 5 A comparison between remifentanil and meperidine for labor analgesia: a systematic review. Anesth Analg Anesthesiology 5 5 Malignant disease within 5 years after surgery in relation to duration of sevoflurane anesthesia and time with bispectral index under 45. Anesth Analg Anesthesiology 7 6 Oncology - General 3 3 Edaravone for acute ischaemic stroke. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 5 6 General Internal Medicine-Primary Care(US) 5 6
Article Title Discipline Rele- vance News- worthiness Meta-analysis of calcineurin-inhibitor-sparing regimens in kidney transplantation. J Am Soc Nephrol Nephrology 7 5 Everolimus plus octreotide long-acting repeatable for the treatment of advanced neuroendocrine tumours associated with carcinoid syndrome (RADIANT-2): a randomised, placebo-controlled, phase 3 study. Lancet Internal Medicine 5 6 Randomized, Prospective Comparison of Plate versus Intramedullary Nail Fixation for Distal Tibia Shaft Fractures. J Orthop Trauma Surgery - Orthopaedics 6 5 The effectiveness of therapeutic exercise for painful shoulder conditions: a meta-analysis. J Shoulder Elbow Surg Internal Medicine 5 5 Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy. N Engl J Med Internal Medicine 6 6 Dronedarone in High-Risk Permanent Atrial Fibrillation. N Engl J Med Cardiology 7 6 The effect of a structured behavioral intervention on poorly controlled diabetes: a randomized controlled trial. Arch Intern Med General Practice(GP)/Family Practice(FP) 5 6 General Internal Medicine-Primary Care(US) 5 6 Comparative effectiveness of patient education methods for type 2 diabetes: a randomized controlled trial. Arch Intern Med Endocrine 7 6 Internal Medicine 6 3 Evaluation of a behavior support intervention for patients with poorly controlled diabetes. Arch Intern Med Endocrine 5 5
Article Title Discipline Rele- vance News- worthiness The effect of ischemic preconditioning on redox status during liver resections--randomized controlled trial. J Surg Oncol Surgery - Gastrointestinal 6 6 Local infiltration analgesia versus intrathecal morphine for postoperative pain management after total knee arthroplasty: a randomized controlled trial. Anesth Analg Surgery - Orthopaedics 6 4 Effects of Nordic walking on health-related quality of life in overweight individuals with Type 2 diabetes mellitus, impaired or normal glucose tolerance. Diabet Med General Practice(GP)/Family Practice(FP) 5 4 General Internal Medicine-Primary Care(US) 5 4 First-trimester ductus venosus screening for cardiac defects: a meta-analysis. BJOG Pediatric Neonatology 5 5 Increase of body weight during the first year of intensive insulin treatment in type 2 diabetes: systematic review and meta-analysis. Diabetes Obes Metab Endocrine 6 5 Effects of initiation and titration of a single pre-prandial dose of insulin glulisine while continuing titrated insulin glargine in type 2 diabetes: a 6-month `proof-of-concept` study. Diabetes Obes Metab Endocrine 5 4 General Practice(GP)/Family Practice(FP) 4 5 General Internal Medicine-Primary Care(US) 4 5
Article Title Discipline Rele- vance News- worthiness Randomized clinical trial of fibrin sealant versus titanium tacks for mesh fixation in laparoscopic umbilical hernia repair. Br J Surg Surgery - Gastrointestinal 6 5 Cost-effectiveness of screening for abdominal aortic aneurysm in the Netherlands and Norway. Br J Surg Surgery - Vascular 6 4 Effect of HER2 status on risk of recurrence in women with small, node-negative breast tumours. Br J Surg Surgery - Oncology 6 5 Oncology - Breast 5 4 Potential effectiveness of three different treatment approaches to improve minimal to moderate arm and hand function after stroke - a pilot randomized clinical trial. Clin Rehabil Physical Medicine and Rehabilitation 5 5 Comparative Benefits and Harms of Second-Generation Antidepressants for Treating Major Depressive Disorder: An Updated Meta-analysis. Ann Intern Med GP/FP/Mental Health 7 6 Efficacy and safety of linagliptin in persons with Type 2 diabetes inadequately controlled by a combination of metformin and sulphonylurea: a 24-week randomized study. Diabet Med Endocrine 6 6 Development and validation of a model that uses enhanced administrative data to predict mortality in patients with sepsis. Crit Care Med Intensivist/Critical Care 5 4 Effect of pravastatin on the frequency of ventilator-associated pneumonia and on intensive care unit mortality: open-label, randomized study. Crit Care Med Infectious Disease 5 6 Angiogenic factors as diagnostic tests for preeclampsia: a performance comparison between two commercial immunoassays. Am J Obstet Gynecol Obstetrics 4 4 Glucagon-like peptide-1 receptor agonists versus insulin in inadequately controlled patients with type 2 diabetes mellitus: a meta-analysis of clinical trials. Diabetes Obes Metab General Practice(GP)/Family Practice(FP) 6 4 General Internal Medicine-Primary Care(US) 6 4 Internal Medicine 5 6 Interventions for treating anxiety after stroke. Cochrane Database Syst Rev GP/FP/Mental Health 6 4 General Internal Medicine-Primary Care(US) 4 3 General Practice(GP)/Family Practice(FP) 4 3 Systemic corticosteroids for acute sinusitis. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 Treatment of tuberculosis and optimal dosing schedules. Thorax General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5
Article Title Discipline Rele- vance News- worthiness Diagnostic value of nasal nitric oxide measured with non-velum closure techniques for children with primary ciliary dyskinesia. J Pediatr Pediatrics (General) 6 5 Do exercise interventions designed to prevent falls affect participation in life roles? A systematic review and meta-analysis. Age Ageing Physical Medicine and Rehabilitation 6 5 General Practice(GP)/Family Practice(FP) 5 3 General Internal Medicine-Primary Care(US) 5 3 Geriatrics 5 3 Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database Syst Rev Pediatrics (General) 7 6 Pediatric Neonatology 5 4 Operative procedures for fissure in ano. Cochrane Database Syst Rev Surgery - Colorectal 6 4 Aerobic exercise training in addition to conventional physiotherapy for chronic low back pain: a randomized controlled trial. Arch Phys Med Rehabil Physical Medicine and Rehabilitation 5 4 Surgery - Orthopaedics 3 3 Gauze and tape and transparent polyurethane dressings for central venous catheters. Cochrane Database Syst Rev Hospital Doctor/Hospitalists 5 5 Internal Medicine 5 5 CHOP-like chemotherapy with or without rituximab in young patients with good-prognosis diffuse large-B-cell lymphoma: 6-year results of an open-label randomised study of the MabThera International Trial (MInT) Group. Lancet Oncol Oncology - Hematology 6 6 Computed tomography score and pulmonary function in infants with chronic lung disease of infancy. Eur Respir J Pediatric Neonatology 5 5 Cost-effectiveness of second-line antihyperglycemic therapy in patients with type 2 diabetes mellitus inadequately controlled on metformin. CMAJ General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Endocrine 5 4 Considerations when prescribing trimethoprim-sulfamethoxazole. CMAJ General Practice(GP)/Family Practice(FP) 7 5 General Internal Medicine-Primary Care(US) 7 5 Infectious Disease 6 3 Naproxen as prophylaxis against atrial fibrillation after cardiac surgery: the NAFARM randomized trial. Am J Med Cardiology 6 6 Mortality from 1 to 16-18 years in bilateral cerebral palsy. Arch Dis Child Neurology 5 5 Recommendations on screening for breast cancer in average-risk women aged 40-74 years. CMAJ Public Health 6 6 Long-term outcome poststroke: predictors of activity limitation and participation restriction. Arch Phys Med Rehabil Neurology 4 4 Effects on 11-year mortality and morbidity of lowering LDL cholesterol with simvastatin for about 5 years in 20 536 high-risk individuals: a randomised controlled trial. Lancet General Practice(GP)/Family Practice(FP) 7 5 General Internal Medicine-Primary Care(US) 7 5 Internal Medicine 6 6 Cardiology 6 6 A systematic review of the effects of e-health on chronically ill patients. J Clin Nurs General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6 Norovirus Vaccine against Experimental Human Norwalk Virus Illness. N Engl J Med General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5
Article Title Discipline Rele- vance News- worthiness Effect of Intracoronary Delivery of Autologous Bone Marrow Mononuclear Cells 2 to 3 Weeks Following Acute Myocardial Infarction on Left Ventricular Function: The LateTIME Randomized Trial. JAMA Cardiology 6 6 The inclusion of stroke in risk stratification for primary prevention of vascular events: the Northern Manhattan Study. Stroke Cardiology 6 6 Using extended cognitive behavioral treatment and medication to treat dependent smokers. Am J Public Health General Practice(GP)/Family Practice(FP) 5 5 GP/FP/Mental Health 5 5 General Internal Medicine-Primary Care(US) 5 5 Randomized Clinical Trial Comparing a Thermosensitive Polymer (LeGoo) With Conventional Vessel Loops for Temporary Coronary Artery Occlusion During Off-Pump Coronary Artery Bypass Surgery. Ann Thorac Surg Surgery - Cardiac 5 4 The effects of CPAP therapy withdrawal in patients with obstructive sleep apnea: a randomised controlled trial. Am J Respir Crit Care Med Respirology/Pulmonology 6 4
Article Title Discipline Rele- vance News- worthiness The ``50% rule`` in arthroscopic and orthopaedic surgery. Arthroscopy Surgery - Orthopaedics 5 5 Oral immunoglobulin for the prevention of rotavirus infection in low birth weight infants. Cochrane Database Syst Rev Pediatric Neonatology 4 5 A prospective randomized controlled trial comparing occupational therapy with independent exercises after volar plate fixation of a fracture of the distal part of the radius. J Bone Joint Surg Am Surgery - Orthopaedics 4 4 Phase II randomized, double-blind, placebo-controlled study of tasquinimod in men with minimally symptomatic metastatic castrate-resistant prostate cancer. J Clin Oncol Oncology - Genitourinary 7 7 Does cementing the femoral component increase the risk of peri-operative mortality for patients having replacement surgery for a fracture of the neck of femur? Data from the National Hip Fracture Database. J Bone Joint Surg Br Surgery - Orthopaedics 6 6 Incidence of and risk factors for neonatal respiratory depression and encephalopathy in rural Sarlahi, Nepal. Pediatrics Pediatric Neonatology 5 4 Pediatrics (General) 4 4 ISSLS prize winner: Function After Spinal Treatment, Exercise, and Rehabilitation (FASTER): a factorial randomized trial to determine whether the functional outcome of spinal surgery can be improved. Spine (Phila Pa 1976) Physical Medicine and Rehabilitation 6 5 Surgery - Orthopaedics 5 5 Adaptive support ventilation for faster weaning in COPD: a randomised controlled trial. Eur Respir J Intensivist/Critical Care 5 5 Respirology/Pulmonology 5 5 Does the baricity of bupivacaine influence intrathecal spread in the prolonged sitting position before elective cesarean delivery? A prospective randomized controlled study. Anesth Analg Obstetrics 5 5 Programmed intermittent epidural bolus versus continuous epidural infusion for labor analgesia: the effects on maternal motor function and labor outcome. A randomized double-blind study in nulliparous women. Anesth Analg Obstetrics 6 6 Survival and prognostic factors in patients with small bowel carcinoid tumour. Br J Surg Oncology - Gastrointestinal 5 5 Efficacy of thalidomide for refractory gastrointestinal bleeding from vascular malformation. Gastroenterology Hematology/Thrombosis 6 6 Cost-effectiveness analysis of a quantitative immunochemical test for colorectal cancer screening. Gastroenterology Gastroenterology 5 4 Screening for prostate cancer: a review of the evidence for the U.S. Preventive Services Task Force. Ann Intern Med General Practice(GP)/Family Practice(FP) 7 6 General Internal Medicine-Primary Care(US) 7 6 Oncology - General 6 6
Article Title Discipline Rele- vance News- worthiness Comparison of bone mineral density changes around short, metaphyseal-fitting, and conventional cementless anatomical femoral components. J Arthroplasty Surgery - Orthopaedics 6 4 Improved clinical outcomes after high-flexion total knee arthroplasty: a 5-year follow-up study. J Arthroplasty Surgery - Orthopaedics 6 6 Are polyaxially locked screws advantageous in the plate osteosynthesis of proximal humeral fractures in the elderly? A prospective randomized clinical observational study. J Orthop Trauma Surgery - Orthopaedics 6 5 Cognitive-behavioral therapy for depression in Parkinson`s disease: a randomized, controlled trial. Am J Psychiatry Psychiatry 5 6 Intraarticular vs. extraarticular ropivacaine infusion following high-dose local infiltration analgesia after total knee arthroplasty. Acta Orthop Surgery - Orthopaedics 5 5 Sulodexide for kidney protection in type 2 diabetes patients with microalbuminuria: a randomized controlled trial. Am J Kidney Dis Nephrology 5 5 Blinded 12-week comparison of once-daily indacaterol and tiotropium in COPD. Eur Respir J Respirology/Pulmonology 6 4 Internal Medicine 5 5 Interventions to reduce primary care delay in cancer referral: a systematic review. Br J Gen Pract General Practice(GP)/Family Practice(FP) 6 4 General Internal Medicine-Primary Care(US) 6 4 A diagnosis of heparin-induced thrombocytopenia with combined clinical and laboratory methods in cardiothoracic surgical intensive care unit patients. Anesth Analg Intensivist/Critical Care 5 5 Hematology/Thrombosis 4 4 Eotaxin-3 in Churg-Strauss syndrome: a clinical and immunogenetic study. Rheumatology (Oxford) Rheumatology 6 6 Meta-analysis of early versus deferred revascularization for non-ST-segment elevation acute coronary syndrome. Am J Cardiol Hospital Doctor/Hospitalists 6 6 Internal Medicine 6 6 Cardiology 5 3 Improving care after myocardial infarction using a 2-year internet-delivered intervention: the department of veterans affairs myocardial infarction-plus cluster-randomized trial. Arch Intern Med General Practice(GP)/Family Practice(FP) 4 4 General Internal Medicine-Primary Care(US) 4 4 Helicobacter pylori Eradication in Functional Dyspepsia: HEROES Trial. Arch Intern Med General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Gastroenterology 6 5 Buried Metaplasia After Endoscopic Ablation of Barrett`s Esophagus: A Systematic Review. Am J Gastroenterol Gastroenterology 6 5 Efficacy of corticosteroid therapy in patients with an acute exacerbation of chronic obstructive pulmonary disease receiving ventilatory support. Arch Intern Med Intensivist/Critical Care 7 4 Association of androgen deprivation therapy with cardiovascular death in patients with prostate cancer: a meta-analysis of randomized trials. JAMA General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6 The effects of whole body vibration therapy on bone mineral density and leg muscle strength in older adults: a systematic review and meta-analysis. Clin Rehabil Geriatrics 5 5 A randomized controlled trial of the effects of muscle stretching, manual therapy and steroid injections in addition to `stay active` care on health-related quality of life in acute or subacute low back pain. Clin Rehabil Rheumatology 5 5 Risk of thiazide-induced hyponatremia in patients with hypertension. Am J Med Hospital Doctor/Hospitalists 6 6 Internal Medicine 6 6 General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Malignancies associated with tumour necrosis factor inhibitors in registries and prospective observational studies: a systematic review and meta-analysis. Ann Rheum Dis Oncology - General 4 4
Article Title Discipline Rele- vance News- worthiness Uterine artery embolization versus surgery in the treatment of symptomatic fibroids: a systematic review and metaanalysis. Am J Obstet Gynecol Gynecology 7 5 Belatacept-versus Cyclosporine-Based Immunosuppression in Renal Transplant Recipients with Pre-existing Diabetes. Clin J Am Soc Nephrol Nephrology 6 5 Thirty- and ninety-day outcomes after sublobar resection with and without brachytherapy for non-small cell lung cancer: results from a multicenter phase III study. J Thorac Cardiovasc Surg Surgery - Thoracic 6 5 CD4 cell count and viral load monitoring in patients undergoing antiretroviral therapy in Uganda: cost effectiveness study. BMJ Infectious Disease 5 4 Bypass Versus Drug-Eluting Stents at Three Years in SYNTAX Patients With Diabetes Mellitus or Metabolic Syndrome. Ann Thorac Surg Cardiology 6 4 Early prevention of pressure ulcers among elderly patients admitted through emergency departments: a cost-effectiveness analysis. Ann Emerg Med Hospital Doctor/Hospitalists 6 6 Internal Medicine 6 6 Dermatology 5 5 Adaptive e-learning to improve dietary behaviour: a systematic review and cost-effectiveness analysis. Health Technol Assess General Practice(GP)/Family Practice(FP) 4 4 General Internal Medicine-Primary Care(US) 4 4 Insulin sensitisers in the treatment of non-alcoholic fatty liver disease: a systematic review. Health Technol Assess Gastroenterology 6 4 High-dose etanercept in ankylosing spondylitis: results of a 12-week randomized, double blind, controlled multicentre study (LOADET study). Rheumatology (Oxford) Rheumatology 6 5 The clinical effectiveness and cost-effectiveness of management strategies for sciatica: systematic review and economic model. Health Technol Assess General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 Transition of care for acute stroke and myocardial infarction patients: from hospitalization to rehabilitation, recovery, and secondary prevention. Evid Rep Technol Assess General Practice(GP)/Family Practice(FP) 6 4 General Internal Medicine-Primary Care(US) 6 4 Optimal warfarin management for the prevention of thromboembolic events in patients with atrial fibrillation: a systematic review of the clinical evidence. . Canadian Agency for Drugs and Technologies in Health (CADTH) General Practice(GP)/Family Practice(FP) 6 4 General Internal Medicine-Primary Care(US) 6 4 Hematology/Thrombosis 5 6 Optimal warfarin management for the prevention of thromboembolic events in patients with atrial fibrillation: review of Canadian economic studies. . Canadian Agency for Drugs and Technologies in Health (CADTH) Internal Medicine 4 4 Efficacy of statins for primary prevention in people at low cardiovascular risk: a meta-analysis. CMAJ General Practice(GP)/Family Practice(FP) 7 5 General Internal Medicine-Primary Care(US) 7 5 Internal Medicine 7 5 Cardiology 6 5
Article Title Discipline Rele- vance News- worthiness Efficacy and safety of combination antiplatelet therapies in patients with symptomatic intracranial atherosclerotic stenosis. Stroke Neurology 6 6 Atorvastatin for the treatment of plaque-type psoriasis. Pharmacotherapy General Practice(GP)/Family Practice(FP) 5 4 General Internal Medicine-Primary Care(US) 5 4 Health status of extremely low-birth-weight children at 8 years of age: child and parent perspective. Arch Pediatr Adolesc Med Psychiatry 5 5 Meta-analysis of monotherapy versus combination therapy for pulmonary arterial hypertension. Am J Cardiol Pediatrics (General) 5 5 Treatment of chronic low back pain: a randomized clinical trial comparing multidisciplinary group-based rehabilitation program and oral drug treatment with oral drug treatment alone. Clin J Pain General Practice(GP)/Family Practice(FP) 5 4 General Internal Medicine-Primary Care(US) 5 4 Special Interest - Pain -- Physician 5 4 Risk of sudden unexpected death in epilepsy in patients given adjunctive antiepileptic treatment for refractory seizures: a meta-analysis of placebo-controlled randomised trials. Lancet Neurol Internal Medicine 5 6 Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open-label substudy. Lancet Neurol General Practice(GP)/Family Practice(FP) 5 4 General Internal Medicine-Primary Care(US) 5 4 Internal Medicine 4 3 Reduced risk of colorectal cancer with metformin therapy in patients with type 2 diabetes: a meta-analysis. Diabetes Care Internal Medicine 5 5 Tai chi exercise for treatment of pain and disability in people with persistent low back pain: A randomized controlled trial. Arthritis Care Res (Hoboken) General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 Special Interest - Pain -- Physician 5 5 Evaluation of Analgesic Efficacy of Intra-Articular Bupivacaine, Bupivacaine Plus Fentanyl, and Bupivacaine Plus Tramadol After Arthroscopic Knee Surgery. Arthroscopy Surgery - Orthopaedics 5 5 Anesthesiology 5 4 Function after spinal treatment, exercise, and rehabilitation: cost-effectiveness analysis based on a randomized controlled trial. Spine (Phila Pa 1976) Surgery - Orthopaedics 5 5 Case identification of depression in patients with chronic physical health problems: a diagnostic accuracy meta-analysis of 113 studies. Br J Gen Pract General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Cost-effectiveness of the use of low- and high-potency statins in people at low cardiovascular risk. CMAJ Cardiology 6 6 General Practice(GP)/Family Practice(FP) 5 3 General Internal Medicine-Primary Care(US) 5 3
Article Title Discipline Rele- vance News- worthiness Does physiotherapy based on the Bobath concept, in conjunction with a task practice, achieve greater improvement in walking ability in people with stroke compared to physiotherapy focused on structured task practice alone?: a pilot randomized controlled trial. Clin Rehabil Physical Medicine and Rehabilitation 5 5 Minocycline-EDTA lock solution prevents catheter-related bacteremia in hemodialysis. J Am Soc Nephrol Infectious Disease 7 6 The effect of weekly risedronate on periprosthetic bone resorption following total hip arthroplasty: a randomized, double-blind, placebo-controlled trial. J Bone Joint Surg Am Surgery - Orthopaedics 5 5 A novel strategy to improve systemic oxygenation in venovenous extracorporeal membrane oxygenation: the ``chi-configuration``. J Thorac Cardiovasc Surg Respirology/Pulmonology 5 6 Use of penicillin and other antibiotics and risk of multiple sclerosis: a population-based case-control study. Am J Epidemiol Infectious Disease 5 6 Phase II/III study of R-CHOP-21 versus R-CHOP-14 for untreated indolent B-cell non-Hodgkin`s lymphoma: JCOG 0203 trial. J Clin Oncol Oncology - Hematology 5 4 A brief sleep intervention improves outcomes in the school entry year: a randomized controlled trial. Pediatrics General Practice(GP)/Family Practice(FP) 5 5 Pediatrics (General) 5 4 Inhaled nitric oxide in preterm infants: an individual-patient data meta-analysis of randomized trials. Pediatrics Respirology/Pulmonology 6 5 Greater weight loss and hormonal changes after 6 months diet with carbohydrates eaten mostly at dinner. Obesity (Silver Spring) Endocrine 6 6 Meta-analysis of randomized controlled trials comparing isolated left ventricular and biventricular pacing in patients with chronic heart failure. Am J Cardiol Hospital Doctor/Hospitalists 5 5 Internal Medicine 5 5 Effects of a home-based walking intervention on mobility and quality of life in people with diabetes and peripheral arterial disease: a randomized controlled trial. Diabetes Care Surgery - Vascular 6 5 Intensive glycaemic control for patients with type 2 diabetes: systematic review with meta-analysis and trial sequential analysis of randomised clinical trials. BMJ General Practice(GP)/Family Practice(FP) 7 5 General Internal Medicine-Primary Care(US) 7 5 Cardiology 6 4 OnabotulinumtoxinA improves quality of life and reduces impact of chronic migraine. Neurology General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 A randomized trial of high-dose vitamin D2 in relapsing-remitting multiple sclerosis. Neurology Neurology 6 5 Randomised placebo-controlled trial of rituximab (anti-CD20) in active ulcerative colitis. Gut Gastroenterology 7 6
Article Title Discipline Rele- vance News- worthiness Hypesthesia after anterolateral versus midline skin incision in TKA: a randomized study. Clin Orthop Relat Res Surgery - Orthopaedics 6 5 Long-Term Effects of Percutaneous Coronary Intervention of the Totally Occluded Infarct-Related Artery in the Subacute Phase After Myocardial Infarction. Circulation Internal Medicine 6 6 Exposure to anti-infective drugs during pregnancy and the risk of small-for-gestational-age newborns: a case-control study. BJOG Infectious Disease 5 5 ADHD drugs and serious cardiovascular events in children and young adults. N Engl J Med General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6 Pediatrics (General) 5 5 Therapeutic approaches in the treatment of juvenile dermatomyositis in patients with recent-onset disease and in those experiencing disease flare: an international multicenter PRINTO study. Arthritis Rheum Rheumatology 6 5 Safety and efficacy of vildagliptin versus placebo in patients with type 2 diabetes and moderate or severe renal impairment: a prospective 24-week randomized placebo-controlled trial. Diabetes Obes Metab Hospital Doctor/Hospitalists 5 5 Internal Medicine 5 5 Effect of normothermic cardiopulmonary bypass on renal injury in pediatric cardiac surgery: a randomized controlled trial. J Thorac Cardiovasc Surg Nephrology 5 5 Medication administration technologies and patient safety: a mixed-method systematic review. J Adv Nurs Hospital Doctor/Hospitalists 5 4 Internal Medicine 5 4 Public release of performance data in changing the behaviour of healthcare consumers, professionals or organisations. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 6 4 General Internal Medicine-Primary Care(US) 6 4 Household obesity prevention: Take Action--a group-randomized trial. Obesity (Silver Spring) Endocrine 5 5 Utility of routine viral load, CD4 cell count, and clinical monitoring among adults with HIV receiving antiretroviral therapy in Uganda: randomised trial. BMJ Internal Medicine 5 5 Long-term clinical outcomes of biodegradable polymer biolimus-eluting stents versus durable polymer sirolimus-eluting stents in patients with coronary artery disease (LEADERS): 4 year follow-up of a randomised non-inferiority trial. Lancet Cardiology 5 5 Full coverage for preventive medications after myocardial infarction. N Engl J Med Cardiology 5 4 Ten sessions of adjunctive left prefrontal rTMS significantly reduces fibromyalgia pain: a randomized, controlled pilot study. Pain Special Interest - Pain -- Physician 6 5
Article Title Discipline Rele- vance News- worthiness Liver cirrhosis and risk of intracerebral hemorrhage: a 9-year follow-up study. Stroke Neurology 6 4 Gastroenterology 5 3 Responsive cortical stimulation for the treatment of medically intractable partial epilepsy. Neurology Neurology 6 6 Mechanical dilatation of the cervix at non-labour caesarean section for reducing postoperative morbidity. Cochrane Database Syst Rev Obstetrics 4 5 The Effect of Lifestyle Modification and Cardiovascular Risk Factor Reduction on Erectile Dysfunction: A Systematic Review and Meta-analysis. Arch Intern Med Surgery - Urology 6 4 General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 Ear wax removal interventions: a systematic review and economic evaluation. Br J Gen Pract General Practice(GP)/Family Practice(FP) 6 3 General Internal Medicine-Primary Care(US) 6 3 Pediatrics (General) 5 4 Does cervical preparation before outpatient hysteroscopy reduce women`s pain experience? A systematic review. BJOG Gynecology 6 5 Use of amino-terminal pro-B-type natriuretic Peptide to guide outpatient therapy of patients with chronic left ventricular systolic dysfunction. J Am Coll Cardiol Internal Medicine 5 5 Cardiology 5 5 Is the operative delivery rate in low-risk women dependent on the level of birth care? A randomised controlled trial. BJOG Obstetrics 6 6 Pediatric Neonatology 5 5 Abciximab and Heparin versus Bivalirudin for Non-ST-Elevation Myocardial Infarction. N Engl J Med Cardiology 7 6 Long-term prognosis of first myocardial infarction according to the electrocardiographic pattern (ST elevation myocardial infarction, non-ST elevation myocardial infarction and non-classified myocardial infarction) and revascularization procedures. Am J Cardiol Emergency Medicine 6 5 Cardiology 5 4 Hospital Doctor/Hospitalists 3 3 Internal Medicine 3 3 Randomized clinical trial of rapid versus 24-hour rehydration for children with acute gastroenteritis. Pediatrics Pediatrics (General) 6 6 Pediatric Emergency Medicine 6 6 Application of wedged foot orthosis effectively reduces pain in runners with pronated foot: a randomized clinical study. Clin Rehabil Physical Medicine and Rehabilitation 5 4 Randomized clinical trial comparing the safety and efficacy of a hydromorphone titration protocol to usual care in the management of adult emergency department patients with acute severe pain. Ann Emerg Med Emergency Medicine 6 5 Nutritional supplements for people being treated for active tuberculosis. Cochrane Database Syst Rev Infectious Disease 6 5 Internal Medicine 5 4 A randomized clinical trial comparing oral, aerosolized intranasal, and aerosolized buccal midazolam. Ann Emerg Med Pediatrics (General) 6 6 Emergency Medicine 6 5 Anesthesiology 4 4 Intracranial hemorrhage is much more common after carotid stenting than after endarterectomy: evidence from the National Inpatient Sample. Stroke Surgery - Vascular 7 6 Effect on behavior problems of teen online problem-solving for adolescent traumatic brain injury. Pediatrics Pediatrics (General) 4 4 Four-year weight losses in the Look AHEAD study: factors associated with long-term success. Obesity (Silver Spring) Internal Medicine 6 5 Endocrine 4 3 Nonpharmacologic treatments for childhood constipation: systematic review. Pediatrics Pediatrics (General) 6 6 General Practice(GP)/Family Practice(FP) 6 4
Article Title Discipline Rele- vance News- worthiness Everolimus-Eluting Versus Sirolimus-Eluting Stents in Patients Undergoing Percutaneous Coronary Intervention The EXCELLENT (Efficacy of Xience/Promus Versus Cypher to Reduce Late Loss After Stenting) Randomized Trial. J Am Coll Cardiol Cardiology 6 6 Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride. Cochrane Database Syst Rev Cardiology 6 5 Effect of dose and combination of antihypertensives on interindividual blood pressure variability: a systematic review. Stroke Neurology 6 5 General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 Functional outcomes of multi-condition collaborative care and successful ageing: results of randomised trial. BMJ Psychiatry 6 6 General Practice(GP)/Family Practice(FP) 5 4 General Internal Medicine-Primary Care(US) 5 4 Is the sentinel node biopsy clinically applicable for limited lymphadenectomy and modified gastric resection in gastric cancer? A meta-analysis of feasibility studies. J Surg Oncol Oncology - Gastrointestinal 5 5 Continuous nasogastric milk feeding versus intermittent bolus milk feeding for premature infants less than 1500 grams. Cochrane Database Syst Rev Pediatric Neonatology 5 4 The utility of high-flow oxygen during emergency department procedural sedation and analgesia with propofol: a randomized, controlled trial. Ann Emerg Med Emergency Medicine 6 5 Association of late-preterm birth with asthma in young children: practice-based study. Pediatrics Respirology/Pulmonology 5 4 Impact of maternal diabetes mellitus on mortality and morbidity of preterm infants (24-33 weeks` gestation). Pediatrics Pediatrics (General) 5 5 Randomized phase II placebo-controlled trial of maintenance therapy using the oral triple angiokinase inhibitor BIBF 1120 after chemotherapy for relapsed ovarian cancer. J Clin Oncol Oncology - Gynecology 4 4 Triphasic versus monophasic oral contraceptives for contraception. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Gynecology 6 5 Cemented all-polyethylene and metal-backed polyethylene tibial components used for primary total knee arthroplasty: a systematic review of the literature and meta-analysis of randomized controlled trials involving 1798 primary total knee implants. J Bone Joint Surg Am Surgery - Orthopaedics 7 5 Fludarabine plus alemtuzumab versus fludarabine alone in patients with previously treated chronic lymphocytic leukaemia: a randomised phase 3 trial. Lancet Oncol Oncology - Hematology 6 6 Disc height and motion patterns in the lumbar spine in patients operated with total disc replacement or fusion for discogenic back pain. Results from a randomized controlled trial. Spine J Surgery - Orthopaedics 6 5 The systemic mediator-associated response test identifies patients in failed sepsis clinical trials among whom novel drugs reduce mortality. J Trauma Hospital Doctor/Hospitalists 5 6 Internal Medicine 5 6 Diagnosis of pneumothorax by radiography and ultrasonography: a meta-analysis. Chest Intensivist/Critical Care 6 4 Safety of early discharge for low-risk patients with febrile neutropenia: a multicenter randomized controlled trial. J Clin Oncol Oncology - General 5 5 Bleeding and stroke risk in a real-world prospective primary prevention cohort of patients with atrial fibrillation. Chest Cardiology 5 5 Performance of the 2010 European Society of Cardiology criteria for ECG interpretation in athletes. Heart Cardiology 6 6 Do antioxidant vitamins have an anti-arrhythmic effect following cardiac surgery? A meta-analysis of randomised controlled trials. Heart Cardiology 5 5 Self-reported atrial fibrillation and risk of stroke in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study. Stroke Cardiology 6 5 Neurology 6 4 Internal Medicine 5 5 General Practice(GP)/Family Practice(FP) 4 3 General Internal Medicine-Primary Care(US) 4 3
Article Title Discipline Rele- vance News- worthiness Cognitive reframing for carers of people with dementia. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 4 4 General Internal Medicine-Primary Care(US) 4 4 Evaluating a complex intervention with a single outcome may not be a good idea: an example from a randomised trial of stroke case management. Age Ageing Geriatrics 5 4 Risk of adverse perinatal outcomes with antithyroid treatment during pregnancy: a nationwide population-based study. BJOG Endocrine 7 6 Obstetrics 6 6 Number of coronary heart disease risk factors and mortality in patients with first myocardial infarction. JAMA Hospital Doctor/Hospitalists 6 4 Internal Medicine 6 4 Hemiarthroplasty versus nonoperative treatment of displaced 4-part proximal humeral fractures in elderly patients: a randomized controlled trial. J Shoulder Elbow Surg Surgery - Orthopaedics 6 7 Preoperative hair removal to reduce surgical site infection. Cochrane Database Syst Rev Surgery - General 7 4 Surgery - Gastrointestinal 5 4 Emergency Medicine 4 4 Oxaliplatin as adjuvant therapy for colon cancer: updated results of NSABP C-07 trial, including survival and subset analyses. J Clin Oncol Oncology - Gastrointestinal 6 5 Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with glimepiride: a randomized, 24-week, double-blind, placebo-controlled trial. Diabetes Obes Metab Internal Medicine 6 6 Endocrine 4 4 Can clinical features distinguish between immobile patients with stroke at high and low risk of deep vein thrombosis? Statistical modelling based on the CLOTS trials cohorts. J Neurol Neurosurg Psychiatry Hematology/Thrombosis 7 5 Dosing clopidogrel based on CYP2C19 genotype and the effect on platelet reactivity in patients with stable cardiovascular disease. JAMA Cardiology 6 5 Premorbid nutrition and short term outcome of stroke: a multicentre study from India. J Neurol Neurosurg Psychiatry Neurology 6 5 Continuous biatrial pacing to prevent early recurrence of atrial fibrillation after the Maze procedure. J Thorac Cardiovasc Surg Surgery - Cardiac 5 5 Cardiology 5 4
Article Title Discipline Rele- vance News- worthiness Safety and effectiveness of a new fibrin pleural air leak sealant: a multicenter, controlled, prospective, parallel-group, randomized clinical trial. Ann Thorac Surg Surgery - Thoracic 6 4 Nonoperative treatment for acute scaphoid fractures: a systematic review and meta-analysis of randomized controlled trials. J Trauma Emergency Medicine 6 5 Surgery - Orthopaedics 6 5 Kidney transplantation with minimized maintenance: alemtuzumab induction with tacrolimus monotherapy--an open label, randomized trial. Transplantation Nephrology 5 4 Randomized clinical trial of perioperative selective decontamination of the digestive tract versus placebo in elective gastrointestinal surgery. Br J Surg Surgery - Gastrointestinal 7 7 Xylitol for preventing acute otitis media in children up to 12 years of age. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 6 5 Active versus expectant management for women in the third stage of labour. Cochrane Database Syst Rev GP/FP/Obstetrics 6 4 Exercise for improving balance in older people. Cochrane Database Syst Rev Geriatrics 6 4 First Results of Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Children. N Engl J Med General Practice(GP)/Family Practice(FP) 5 6 Ovarian stimulation and low birth weight in newborns conceived through in vitro fertilization. Obstet Gynecol Endocrine 6 5 Pediatric Neonatology 5 5 Co-twin prognosis after single fetal death: a systematic review and meta-analysis. Obstet Gynecol Pediatric Neonatology 6 5 Predictors of early and late case-fatality in a nationwide Danish study of 26,818 patients with first-ever ischemic stroke. Stroke Neurology 5 4 Intensified chemotherapy with ACVBP plus rituximab versus standard CHOP plus rituximab for the treatment of diffuse large B-cell lymphoma (LNH03-2B): an open-label randomised phase 3 trial. Lancet Oncology - Hematology 6 5 Self-collection of vaginal specimens for human papillomavirus testing in cervical cancer prevention (MARCH): a community-based randomised controlled trial. Lancet Public Health 6 6 General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Gynecology 5 6 A novel approach in allergen-specific immunotherapy: combination of sublingual and subcutaneous routes. J Allergy Clin Immunol Allergy and Immunology 5 6 General Practice(GP)/Family Practice(FP) 4 3 General Internal Medicine-Primary Care(US) 4 3 Statin Therapy for the Prevention of Atrial Fibrillation: A Meta-analysis of Randomized Controlled Trials. Pharmacotherapy General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6 Cardiology 4 4
Article Title Discipline Rele- vance News- worthiness Diagnostic management strategies for adults and children with minor head injury: a systematic review and an economic evaluation. Health Technol Assess Emergency Medicine 6 5 Zinc supplementation as an adjunct to antibiotics in the treatment of pneumonia in children 2 to 59 months of age. Cochrane Database Syst Rev Pediatrics (General) 4 4 Randomized trial of immunosuppressive regimens in renal transplantation. J Am Soc Nephrol Nephrology 6 6 Risk of acute pancreatitis in type 2 diabetes and risk reduction on anti-diabetic drugs: a population-based cohort study in Taiwan. Am J Gastroenterol Endocrine 5 6
Article Title Discipline Rele- vance News- worthiness Interventions for latent autoimmune diabetes (LADA) in adults. Cochrane Database Syst Rev Endocrine 5 4 Focal fat lesions at vertebral corners on magnetic resonance imaging predict the development of new syndesmophytes in ankylosing spondylitis. Arthritis Rheum Rheumatology 5 5 Clinical outcome of a randomized controlled blinded trial of open versus laparoscopic Nissen fundoplication in infants and children. Ann Surg Pediatric Hospital Medicine 5 4 Meta-analysis of desflurane and propofol average times and variability in times to extubation and following commands. Can J Anaesth Anesthesiology 6 5 Early deaths during tuberculosis treatment are associated with depressed innate responses, bacterial infection, and tuberculosis progression. J Infect Dis Tropical and Travel Medicine 5 4 Non-clinical interventions that increase the uptake and success of vaginal birth after caesarean section: a systematic review. J Adv Nurs Obstetrics 6 5 Manual lymph drainage improving upper extremity edema and hand function in patients with systemic sclerosis in edematous phase. Arthritis Care Res (Hoboken) Rheumatology 5 5 Derivation and validation of a model to predict daily risk of death in hospital. Med Care Hospital Doctor/Hospitalists 4 5 Internal Medicine 4 5 Phase I/IIa trial of autologous formalin-fixed tumor vaccine concomitant with fractionated radiotherapy for newly diagnosed glioblastoma. Clinical article. J Neurosurg Surgery - Neurosurgery 4 5 A novel reflux inhibitor lesogaberan (AZD3355) as add-on treatment in patients with GORD with persistent reflux symptoms despite proton pump inhibitor therapy: a randomised placebo-controlled trial. Gut Gastroenterology 5 5 Development and evaluation by a cluster randomised trial of a psychosocial intervention in children and teenagers experiencing diabetes: the DEPICTED study. Health Technol Assess General Practice(GP)/Family Practice(FP) 5 4 Randomized, Placebo-Controlled Clinical Trial of an Aerosolized Beta-2 Agonist for Treatment of Acute Lung Injury. Am J Respir Crit Care Med Hospital Doctor/Hospitalists 6 7 Internal Medicine 6 7 Randomized clinical trial of ischaemic preconditioning in major liver resection with intermittent Pringle manoeuvre. Br J Surg Surgery - Gastrointestinal 6 6 One-year prognosis after syncope and the failure of the ROSE decision instrument to predict one-year adverse events. Ann Emerg Med Cardiology 6 5
Article Title Discipline Rele- vance News- worthiness Validation of a novel staging system for disease-specific survival in patients with breast cancer treated with neoadjuvant chemotherapy. J Clin Oncol Oncology - Breast 5 4 Logistic risk model for mortality following elective abdominal aortic aneurysm repair. Br J Surg Surgery - Vascular 6 5 Functional residual capacity-guided alveolar recruitment strategy after endotracheal suctioning in cardiac surgery patients. Crit Care Med Surgery - General 4 5 Efficacy of a workplace-based weight loss program for overweight male shift workers: the Workplace POWER (Preventing Obesity Without Eating like a Rabbit) randomized controlled trial. Prev Med Occupational and Environmental Health 6 5 General Practice(GP)/Family Practice(FP) 5 4 General Internal Medicine-Primary Care(US) 5 4 Influence of preceding length of anticoagulant treatment and initial presentation of venous thromboembolism on risk of recurrence after stopping treatment: analysis of individual participants` data from seven trials. BMJ Hematology/Thrombosis 6 6 General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Dexamethasone and length of hospital stay in patients with community-acquired pneumonia: a randomised, double-blind, placebo-controlled trial. Lancet Hospital Doctor/Hospitalists 5 5 Internal Medicine 5 5
Remote Access with VNC On the Windows computer you will be using from outside the center: • 1. Download putty.exe from here . • 2. Download Ultr@VNC Standalone Viewer . 3. Open Putty and open a connection to Host Name gate.nmr.mgh.harvard.edu 4. From gate ssh to your linux workstation. (In this example user 'mehlsa' is connecting to a workstation named 'crusoe') 5. Once connected to your workstation, run the command /usr/pubsw/bin/vncpasswd . Enter and confirm a password that you will use to connect remotely. 6. Run the command /usr/pubsw/bin/vncserver.glx 7. You must note the number value that is returned for your remote desktop. In this example the value is 1 . You do not normally need to run steps 5-7 every time you connect. Unless your workstation has rebooted or you have explicitly killed your VNC server process, the vncserver.glx program will still be running. After connecting to your workstation run /usr/pubsw/bin/vnccheck to see see if the process is still running. This will also show you the desktop number (the number after the colon) you need for the tunnel. • 8. Open a new putty window. • 9. Enter gate.nmr.mgh.harvard.edu for the Host Name and enter gate_vnc for the Saved Sessions. • 10. In the category menu on the left, click on "Tunnels" • 11. Enter a Source port of 5905 . • 12. For the Destination, you should enter the name of the linux workstation that is running vncserver.glx followed by a colon and 590X where "X" is the number you noted in step #7 above. . (In this example, we are attempting to create a tunnel to the destination crusoe:5901 ). • 13. You must click the 'Add' button. • 14. In the category menu on the left, click on "Session" • 15. Click the 'Save' button to save all the changes you've made. • 16. Now double-click on ' gate_vnc ' to open a terminal window. • 17. Login using your NMR username and password. Once you have logged in, you can minimize the window. As long as the window remains open, the tunnel will exist and you will be able to use VNC. • 18. Open. UltraVNC Viewer. • 19. You must enter localhost:5905 as the Server. Then press Connect. • 20. Use the password you set in step #5 to connect. • 21. Once connected, you can click on the icon in the upper-left hand corner of the screen to display a menu with some commonly uses commands.
Navigate the Research Publication Process with Publishing Your Research 101 Watch the video ACS Publications knows that effective communication of scientific research is vital both to the scientific community and to your scientific career. But sometimes the process of getting your research from the lab to a peer-reviewed journal isn't always simple. That is why ACS Publications has introduced Publishing Your Research 101 , a new educational video series, to assist authors and reviewers with the processes of writing, submitting, editing, and reviewing manuscripts. The first video in the series, "How to Write a Paper to Communicate Your Research," features Professor George M. Whitesides of Harvard University, whose publishing record includes nearly 600 papers in 17 different ACS journals, and over 1100 articles overall; he has also served on the advisory boards of numerous peer-reviewed journals. He has made significant contributions to areas as diverse as nuclear magnetic resonance spectroscopy, organic synthesis, materials and surface science, microfluidics, and nanotechnology. Episode 1: How to Write a Paper to Communicate your Research Watch the video Professor Whitesides answers some of the key questions about manuscript preparation, such as: When should I begin to think about writing up my research for publication? How should I handle the approach of writing while I research? How do new technologies help scientists communicate their work? How many drafts should each paper undergo? Should they undergo an internal review? Do I need to be thinking of actively marketing my articles? How concerned should I be about the title and abstract of my papers? Coming Soon Episode 2: Writing Your Cover Letter will be released in June 2011. The video identifies topics to be discussed in the cover letter that accompanies your original research manuscript, such as how best to communicate the significance of the research to the field, and how the subject of the research study fits with the scope of the journal and its audience of readers. It features interviews with: Inorganic Chemistry Editor-in-Chief Richard Eisenberg, University of Rochester Macromolecules Editor-in-Chief TImothy P. Lodge, University of Minnesota ACS Nano Associate Editor Paula T. Hammond, Massachusetts Institute of Technology ACS Nano Associate Editor Jason H. Hafner, Rice University Topics of future episodes will include: The essential elements of an accepted manuscript Ethical considerations for authors and reviewers Selecting a journal for submission Responding to reviewer comments and manuscript rejections Tips for non-native English speakers Be sure to visit http://pubs.acs.org/r/publishing101 regularly for new episodes! 1155 Sixteenth Street NW Washington, DC 20036
Article Title Discipline Rele- vance News- worthiness alpha-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study. Lancet Neurol Neurology 5 5 Treatment with trastuzumab for 1 year after adjuvant chemotherapy in patients with HER2-positive early breast cancer: a 4-year follow-up of a randomised controlled trial. Lancet Oncol Oncology - Breast 6 5 Electromagnetic field stimulation for treating delayed union or non-union of long bone fractures in adults. Cochrane Database Syst Rev Surgery - Orthopaedics 6 6 Rehabilitation with mental practice has similar effects on mobility as rehabilitation with relaxation in people with Parkinson`s disease: a multicentre randomised trial. J Physiother Neurology 5 4 Physical Medicine and Rehabilitation 5 4 Effect of continuous glucose monitoring on hypoglycemia in type 1 diabetes. Diabetes Care Pediatrics (General) 5 5 General Practice(GP)/Family Practice(FP) 5 4 General Internal Medicine-Primary Care(US) 5 4 Systematic review: blood pressure target in chronic kidney disease and proteinuria as an effect modifier. Ann Intern Med Nephrology 6 6 Intraoperative Tranexamic Acid Reduces Blood Transfusion in Children Undergoing Craniosynostosis Surgery: A Randomized Double-blind Study. Anesthesiology Anesthesiology 6 6 Preoperative Dexamethasone Enhances Quality of Recovery after Laparoscopic Cholecystectomy: Effect on In-hospital and Postdischarge Recovery Outcomes. Anesthesiology Surgery - Gastrointestinal 6 5 Anesthesiology 6 5 Hospital Doctor/Hospitalists 5 6 Internal Medicine 5 6 Initiatives to shorten duration of untreated psychosis: systematic review. Br J Psychiatry GP/FP/Mental Health 5 4 A Systematic Review and Meta-Analysis of Placebo-Controlled Antidepressant Studies in People with Depression and Dementia J Am Geriatr Soc Hospital Doctor/Hospitalists 7 5 Internal Medicine 7 5 Effect of Exercise on Cognitive Performance in Community-Dwelling Older Adults: Review of Intervention Trials and Recommendations for Public Health Practice and Research. J Am Geriatr Soc Geriatrics 6 5 Interventions for encouraging sexual behaviours intended to prevent cervical cancer. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 6 4 General Internal Medicine-Primary Care(US) 6 4 Infectious Disease 4 3 Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial. JAMA Endocrine 5 4 Interventions for preventing oral mucositis for patients with cancer receiving treatment. Cochrane Database Syst Rev Oncology - Hematology 6 5 Oncology - Genitourinary 5 4 Oncology - General 5 4
Article Title Discipline Rele- vance News- worthiness Competitions and incentives for smoking cessation. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 4 4 General Internal Medicine-Primary Care(US) 4 4 Beyond the Monofilament for the Insensate Diabetic Foot: A systematic review of randomized trials to prevent the occurrence of plantar foot ulcers in patients with diabetes. Diabetes Care Internal Medicine 7 5 General Practice(GP)/Family Practice(FP) 6 4 General Internal Medicine-Primary Care(US) 6 4 Randomized clinical trial of endovenous laser ablation compared with conventional surgery for great saphenous varicose veins. Br J Surg Surgery - Vascular 6 5 Tai chi exercise in patients with chronic heart failure: a randomized clinical trial. Arch Intern Med General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 Support surfaces for pressure ulcer prevention. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Hospital Doctor/Hospitalists 6 5 Internal Medicine 6 5 Use of varenicline for 4 weeks before quitting smoking: decrease in ad lib smoking and increase in smoking cessation rates. Arch Intern Med Respirology/Pulmonology 6 6 Comparison of different treatment protocols in the treatment of idiopathic detrusor overactivity: a randomized controlled trial. Clin Rehabil General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5
Article Title Discipline Rele- vance News- worthiness Comparison of inhaled nitric oxide versus oxygen on hemodynamics in patients with mitral stenosis and severe pulmonary hypertension after mitral valve surgery. Am J Cardiol Surgery - Vascular 4 4 A randomized trial of day-case vs inpatient laparoscopic supracervical hysterectomy. Am J Obstet Gynecol Gynecology 6 6 Is transcervical Foley catheter actually slower than prostaglandins in ripening the cervix? A randomized study. Am J Obstet Gynecol Obstetrics 6 5 Risk of death and hospital admission for major medical events after initiation of psychotropic medications in older adults admitted to nursing homes. CMAJ Geriatrics 6 6 Anticoagulation for patients with cancer and central venous catheters. Cochrane Database Syst Rev Oncology - Hematology 6 5 Anticoagulation for the initial treatment of venous thromboembolism in patients with cancer. Cochrane Database Syst Rev Oncology - Hematology 5 4 Oncology - Lung 4 5 Effect of oxandrolone and timing of pubertal induction on final height in Turner`s syndrome: randomised, double blind, placebo controlled trial. BMJ Pediatrics (General) 6 5 Chronic beta Blockade Is Associated with a Better Outcome after Elective Noncardiac Surgery than Acute beta Blockade: A Single-center Propensity-matched Cohort Study. Anesthesiology Hospital Doctor/Hospitalists 6 6 Internal Medicine 6 6 Cardiology 6 5 Postcards in Persia: randomised controlled trial to reduce suicidal behaviours 12 months after hospital-treated self-poisoning. Br J Psychiatry Psychiatry 6 5 Risk of Bladder Cancer Among Diabetic Patients Treated With Pioglitazone: Interim report of a longitudinal cohort study. Diabetes Care Internal Medicine 6 6 Endocrine 6 6 General Practice(GP)/Family Practice(FP) 5 6 General Internal Medicine-Primary Care(US) 5 6 Interventions to improve teamwork and communications among healthcare staff. Br J Surg Hospital Doctor/Hospitalists 5 5 Internal Medicine 5 5 Pediatrics (General) 5 3 General Practice(GP)/Family Practice(FP) 4 3 General Internal Medicine-Primary Care(US) 4 3 Use of Angiotensin Receptor Blockers and the Risk of Cancer. Circulation Cardiology 5 4 General Practice(GP)/Family Practice(FP) 5 3 General Internal Medicine-Primary Care(US) 5 3 Early results from a randomized trial of saphenous surgery with or without subfascial endoscopic perforator surgery in patients with a venous ulcer. Br J Surg Surgery - Vascular 6 5 Multicentre evaluation of intraoperative molecular analysis of sentinel lymph nodes in breast carcinoma. Br J Surg Surgery - Oncology 6 5 Long-term follow-up of patients with a painless inguinal hernia from a randomized clinical trial. Br J Surg General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5
Article Title Discipline Rele- vance News- worthiness Progressive strength training in older patients after hip fracture: a randomised controlled trial. Age Ageing Geriatrics 6 5 Frovatriptan as preemptive treatment for fasting-induced migraine. Headache Special Interest - Pain -- Physician 5 5 Electronic patient messages to promote colorectal cancer screening: a randomized controlled trial. Arch Intern Med General Practice(GP)/Family Practice(FP) 5 4 General Internal Medicine-Primary Care(US) 5 4 Oncology - General 4 5 Effectiveness and Safety of Percutaneous Coronary Intervention After Fibrinolytic Therapy for ST-Segment Elevation Acute Myocardial Infarction. Am J Cardiol Internal Medicine 5 5 Effectiveness of antenatal corticosteroids in reducing respiratory disorders in late preterm infants: randomised clinical trial. BMJ Pediatric Neonatology 7 6 Group therapy for adolescents with repeated self harm: randomised controlled trial with economic evaluation. BMJ GP/FP/Mental Health 6 5 Hypotensive resuscitation strategy reduces transfusion requirements and severe postoperative coagulopathy in trauma patients with hemorrhagic shock: preliminary results of a randomized controlled trial. J Trauma Hematology/Thrombosis 6 6 Surgery - General 5 5 Nutritional supplements and other complementary medicines for infantile colic: a systematic review. Pediatrics General Practice(GP)/Family Practice(FP) 6 5 Pediatrics (General) 6 4 Pediatric Neonatology 6 4 Effect of nicotine replacement therapy on agitation in smokers with schizophrenia: a double-blind, randomized, placebo-controlled study. Am J Psychiatry Psychiatry 6 5 General Practice(GP)/Family Practice(FP) 4 3 Antidepressant drug compliance: reduced risk of MI and mortality in depressed patients. Am J Med Psychiatry 7 6 Cardiology 6 6 Internal Medicine 6 5 Comparison of bupivacaine and 2-chloroprocaine for spinal anesthesia for outpatient surgery: a double-blind randomized trial. Can J Anaesth Anesthesiology 6 5 Non-pharmacological interventions for perceptual disorders following stroke and other adult-acquired, non-progressive brain injury. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 Physical Medicine and Rehabilitation 5 5 Medical interventions for high grade vulval intraepithelial neoplasia. Cochrane Database Syst Rev Oncology - Gynecology 6 5 Trans-obturator tape compared with tension-free vaginal tape in the surgical treatment of stress urinary incontinence: a cost utility analysis. BJOG Gynecology 5 6 Surgery - Urology 5 4 Single-Dose Fosaprepitant for the Prevention of Chemotherapy-Induced Nausea and Vomiting Associated With Cisplatin Therapy: Randomized, Double-Blind Study Protocol--EASE. J Clin Oncol Oncology - General 5 5 Clinical Significance of Circulating Tumor Cells, Including Cancer Stem-Like Cells, in Peripheral Blood for Recurrence and Prognosis in Patients With Dukes` Stage B and C Colorectal Cancer. J Clin Oncol Internal Medicine 5 5
Article Title Discipline Rele- vance News- worthiness Specific oral tolerance induction in food allergic children: is oral desensitisation more effective than allergen avoidance?: a meta-analysis of published RCTs. Arch Dis Child Pediatrics (General) 5 6 The Efficacy of Proton Pump Inhibitors for the Treatment of Asthma in Adults: A Meta-analysis. Arch Intern Med Gastroenterology 6 5 Comparison of dual drug-eluting cilotax stent and Paclitaxel-eluting taxus liberte stent in native coronary artery lesions. Am J Cardiol Cardiology 5 5 High-dose intracoronary adenosine for myocardial salvage in patients with acute ST-segment elevation myocardial infarction. Eur Heart J Cardiology 5 6 A pharmacodynamic comparison of prasugrel vs. high-dose clopidogrel in patients with type 2 diabetes mellitus and coronary artery disease: results of the Optimizing anti-Platelet Therapy In diabetes MellitUS (OPTIMUS)-3 Trial. Eur Heart J Endocrine 6 6 Cardiology 5 3 Reduction in 24-hour plasma testosterone levels in subjects who showered 15 or 30 minutes after application of testosterone gel. Pharmacotherapy Surgery - Urology 6 5 A randomised controlled trial of post-operative radiotherapy following breast-conserving surgery in a minimum-risk population. Quality of life at 5 years in the PRIME trial. Health Technol Assess Oncology - Breast 6 6 Effect of Antibiotic Exposure on Nugent Score Among Pregnant Women With and Without Bacterial Vaginosis. Obstet Gynecol GP/FP/Obstetrics 6 5 Strength training alone, exercise therapy alone, and exercise therapy with passive manual mobilisation each reduce pain and disability in people with knee osteoarthritis: a systematic review. J Physiother Physical Medicine and Rehabilitation 6 5 The 90 degrees rotation technique improves the ease of insertion of the ProSeal laryngeal mask airway in children. Can J Anaesth Anesthesiology 6 5 Pediatric Hospital Medicine 3 4 Cilostazol attenuates on-treatment platelet reactivity in patients with CYP2C19 loss of function alleles receiving dual antiplatelet therapy: a genetic substudy of the CILON-T randomised controlled trial. Heart Cardiology 6 6 Genetics 5 6 Progestin-only contraceptives: effects on weight. Cochrane Database Syst Rev Gynecology 6 6 Recurrence risk and prediction of a delivery under 34 weeks of gestation after a history of a severe hypertensive disorder. BJOG Obstetrics 7 5 Intra-articular lignocaine versus intravenous analgesia with or without sedation for manual reduction of acute anterior shoulder dislocation in adults. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 4 4 General Internal Medicine-Primary Care(US) 4 4 Colonic stenting versus emergency surgery for acute left-sided malignant colonic obstruction: a multicentre randomised trial. Lancet Oncol Oncology - Gastrointestinal 6 6 Systematic Review: Benefits and Harms of In-Hospital Use of Recombinant Factor VIIa for Off-Label Indications. Ann Intern Med Hematology/Thrombosis 7 6 Neurology 6 5 Hospital Doctor/Hospitalists 5 6 Internal Medicine 5 6
Article Title Discipline Rele- vance News- worthiness A comparison of sartorius versus quadriceps stimulation for femoral nerve block: a prospective randomized double-blind controlled trial. Anesth Analg Anesthesiology 6 5 Skin-Derived Tenocyte-like Cells for the Treatment of Patellar Tendinopathy. Am J Sports Med Rheumatology 6 5 Fast-track surgery for bilateral total knee replacement. J Bone Joint Surg Br Surgery - Orthopaedics 6 5 Atazanavir Plus Ritonavir or Efavirenz as Part of a 3-Drug Regimen for Initial Treatment of HIV-1: A Randomized Trial. Ann Intern Med Public Health 5 4 Randomized trial of mediastinal lymph node sampling versus complete lymphadenectomy during pulmonary resection in the patient with N0 or N1 (less than hilar) non-small cell carcinoma: results of the American College of Surgery Oncology Group Z0030 Trial. J Thorac Cardiovasc Surg Surgery - Oncology 7 6 Virus serology in patients with suspected myocarditis: utility or futility?. Eur Heart J Infectious Disease 5 6 Cardiology 5 5 Health literacy interventions and outcomes: an updated systematic review. Evid Rep Technol Assess General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 Glucocorticosteroid therapy in inflammatory bowel disease: systematic review and meta-analysis. Am J Gastroenterol Gastroenterology 6 5 Nutrient Enrichment of Mother`s Milk and Growth of Very Preterm Infants After Hospital Discharge. Pediatrics Pediatric Neonatology 6 4 Immunogenicity and reactogenicity of alternative schedules of HPV vaccine in Vietnam: a cluster randomized noninferiority trial. JAMA Infectious Disease 6 6 Public Health 6 6 Intravenous immunoglobulin in neonates with rhesus hemolytic disease: a randomized controlled trial. Pediatrics Pediatrics (General) 6 6 Hematology/Thrombosis 5 5 Acupuncture for carpal tunnel syndrome: a systematic review of randomized controlled trials. J Pain General Practice(GP)/Family Practice(FP) 5 4 General Internal Medicine-Primary Care(US) 5 4 Rheumatology 5 4 Special Interest - Pain -- Physician 4 3 Intervention to reduce transmission of resistant bacteria in intensive care. N Engl J Med Hospital Doctor/Hospitalists 6 6 Internal Medicine 6 6 Intensivist/Critical Care 6 6 Efficacy and safety of oral versus intravenous Ibuprofen in very low birth weight preterm infants with patent ductus arteriosus. J Pediatr Pediatrics (General) 6 6
Article Title Discipline Rele- vance News- worthiness Prognostic value of an RNA expression signature derived from cell cycle proliferation genes in patients with prostate cancer: a retrospective study. Lancet Oncol Oncology - Genitourinary 4 5 A comparison of the results of anterior cruciate ligament reconstruction using bioabsorbable versus metal interference screws: a meta-analysis. J Bone Joint Surg Am Surgery - Orthopaedics 6 5 Maintenance peginterferon therapy and other factors associated with hepatocellular carcinoma in patients with advanced hepatitis C. Gastroenterology Gastroenterology 5 4 Lipid paradox in rheumatoid arthritis: the impact of serum lipid measures and systemic inflammation on the risk of cardiovascular disease. Ann Rheum Dis Rheumatology 5 4 An accelerated Ponseti versus the standard Ponseti method: a prospective randomised controlled trial. J Bone Joint Surg Br Surgery - Orthopaedics 6 6 Pediatrics (General) 5 4 Superior fixation of pegged trabecular metal over screw-fixed pegged porous titanium fiber mesh. Acta Orthop Surgery - Orthopaedics 6 5 Comparison of trabecular metal cups and titanium fiber-mesh cups in primary hip arthroplasty. Acta Orthop Surgery - Orthopaedics 7 6 Ability of nurses to identify depression in primary care, secondary care and nursing homes-A meta-analysis of routine clinical accuracy. Int J Nurs Stud GP/FP/Mental Health 6 6 Hyperbaric oxygen therapy: solution for difficult to heal acute wounds? Systematic review. World J Surg Intensivist/Critical Care 6 4 Meta-analysis of selective serotonin reuptake inhibitors in patients with depression and coronary heart disease. Am J Cardiol General Practice(GP)/Family Practice(FP) 6 6 Psychiatry 6 5 Pediatric Trauma BIG Score: Predicting Mortality in Children After Military and Civilian Trauma. Pediatrics Emergency Medicine 5 5 The diagnostic performance of multi-slice coronary computed tomographic angiography: a systematic review. J Gen Intern Med Cardiology 5 4 Efficacy and safety of a 4-drug fixed-dose combination regimen compared with separate drugs for treatment of pulmonary tuberculosis: the Study C randomized controlled trial. JAMA Infectious Disease 5 5 Safety and immunogenicity of 4 intramuscular double doses and 4 intradermal low doses vs standard hepatitis B vaccine regimen in adults with HIV-1: a randomized controlled trial. JAMA Gastroenterology 5 4
Article Title Discipline Rele- vance News- worthiness Clinical tests to diagnose lumbar segmental instability: a systematic review. J Orthop Sports Phys Ther Special Interest - Pain -- Physician 6 6 Oesophagogastric junction adenocarcinoma: which therapeutic approach?. Lancet Oncol Oncology - Gastrointestinal 6 4 Out-of-hospital tracheal intubation with single-use versus reusable metal laryngoscope blades: a multicenter randomized controlled trial. Ann Emerg Med Emergency Medicine 6 6 Diagnostic accuracy of enthesis ultrasound in the diagnosis of early spondyloarthritis. Ann Rheum Dis Rheumatology 6 5 Nurse-led interventions used to improve control of high blood pressure in people with diabetes: a systematic review and meta-analysis. Diabet Med General Practice(GP)/Family Practice(FP) 5 4 General Internal Medicine-Primary Care(US) 5 4 Endocrine 5 3 Impact of Coronary Artery Calcium Scanning on Coronary Risk Factors and Downstream Testing The EISNER (Early Identification of Subclinical Atherosclerosis by Noninvasive Imaging Research) Prospective Randomized Trial. J Am Coll Cardiol General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Effect of liposomal lidocaine and sucrose alone and in combination for venipuncture pain in newborns. Pediatrics Pediatrics (General) 6 6
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Article Title Discipline Rele- vance News- worthiness Randomized controlled trial of cephalexin versus clindamycin for uncomplicated pediatric skin infections. Pediatrics Pediatrics (General) 7 6 Effect of atorvastatin on inflammation and modification of vascular risk factors in rheumatoid arthritis. J Rheumatol Rheumatology 5 6 The Diabeo Software Enabling Individualized Insulin Dose Adjustments Combined With Telemedicine Support Improves HbA1c in Poorly Controlled Type 1 Diabetic Patients: A 6-month, randomized, open-label, parallel-group, multicenter trial (TeleDiab 1 Study). Diabetes Care General Practice(GP)/Family Practice(FP) 4 4 General Internal Medicine-Primary Care(US) 4 4 In patients younger than age 55 years with lymph node-negative breast cancer, proliferation by mitotic activity index is prognostically superior to adjuvant!. J Clin Oncol Surgery - Oncology 7 6 Oncology - Breast 5 6
Article Title Discipline Rele- vance News- worthiness Validity of the NIHSS in predicting arterial occlusion in cerebral infarction is time-dependent. Neurology Neurology 6 4 Raloxifene, a selective estrogen receptor modulator, is renoprotective: a post-hoc analysis. Kidney Int Nephrology 6 4 Rheumatology 4 4 Hypoglycemia in glyburide-treated gestational diabetes: is it dose-dependent?. Obstet Gynecol Internal Medicine 4 4 Endocrine 4 3 Effect of plantar vibration stimuli on the balance of older women: a randomized controlled trial. Arch Phys Med Rehabil Geriatrics 5 4 Comparison of the effect of low-dose ciclesonide and fixed-dose fluticasone propionate and salmeterol combination on long-term asthma control. Chest General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 The Impact of Surgery on Survival of Patients With Cutaneous Melanoma: Revisiting the Role of Primary Tumor Excision Margins. Ann Surg Surgery - Plastic 7 5 Oncology - General 6 5 Early diagnosis of intestinal ischemia using urinary and plasma Fatty Acid binding proteins. Ann Surg Surgery - General 6 6 Surgery - Gastrointestinal 6 6 Emergency Medicine 5 4 The effect of pramlintide acetate on glycemic control and weight in patients with type 2 diabetes mellitus and in obese patients without diabetes: a systematic review and meta-analysis. Diabetes Obes Metab Endocrine 6 5 General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 Comparison of an intermittent high-intensity vs continuous low-intensity physiotherapy service over 12 months in community-dwelling people with stroke: a randomized trial. Clin Rehabil Physical Medicine and Rehabilitation 6 5 Neurology 4 3 The effects of oral ibuprofen and celecoxib in preventing pain, improving recovery outcomes and patient satisfaction after ambulatory surgery. Anesth Analg Surgery - Orthopaedics 5 4 Gastric Bypass vs Sleeve Gastrectomy for Type 2 Diabetes Mellitus: A Randomized Controlled Trial. Arch Surg Surgery - Gastrointestinal 7 6 Endocrine 6 6 Nitrous oxide and long-term morbidity and mortality in the ENIGMA trial. Anesth Analg Surgery - General 4 4 Urinary C-peptide creatinine ratio is a practical outpatient tool for identifying hepatocyte nuclear factor 1-{alpha}/hepatocyte nuclear factor 4-{alpha} maturity-onset diabetes of the young from long-duration type 1 diabetes. Diabetes Care Endocrine 5 6 A randomized comparison of right ventricular function after on-pump versus off-pump coronary artery bypass graft surgery. J Thorac Cardiovasc Surg Surgery - Cardiac 7 5 Olmesartan for the delay or prevention of microalbuminuria in type 2 diabetes. N Engl J Med General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6 Endocrine 6 5
Article Title Discipline Rele- vance News- worthiness Compulsory community and involuntary outpatient treatment for people with severe mental disorders. Cochrane Database Syst Rev Psychiatry 6 5 Delivery and outcomes of a yearlong home exercise program after hip fracture: a randomized controlled trial. Arch Intern Med Physical Medicine and Rehabilitation 5 5 Cohort study to test the predictability of the Melbourne criteria for activation of the medical emergency team. Arch Dis Child Pediatric Hospital Medicine 5 5 Ketamine with and without midazolam for emergency department sedation in adults: a randomized controlled trial. Ann Emerg Med Anesthesiology 5 4 Procalcitonin as a Biomarker for Bacterial Infections in Patients With Liver Cirrhosis in the Emergency Department. Acad Emerg Med Emergency Medicine 5 3 Gastroenterology 4 4 Behaviorally defined patient-centered communication--a narrative review of the literature. J Gen Intern Med Internal Medicine 4 4 Irbesartan in patients with atrial fibrillation. N Engl J Med General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 Cardiology 5 5 Screening adults aged 50 years or older for hearing loss: a review of the evidence for the U.S. Preventive services task force. Ann Intern Med Geriatrics 5 4
Article Title Discipline Rele- vance News- worthiness Treatment for postpolio syndrome. Cochrane Database Syst Rev Neurology 5 5 Short-term outcomes of induction therapy with tacrolimus versus cyclophosphamide for active lupus nephritis: A multicenter randomized clinical trial. Am J Kidney Dis Nephrology 6 6 Nosocomial transmission of sporadic Creutzfeldt-Jakob disease: results from a risk-based assessment of surgical interventions. J Neurol Neurosurg Psychiatry Surgery - Orthopaedics 4 5 Computer- and web-based interventions to increase preadolescent and adolescent physical activity: a systematic review. J Adv Nurs Endocrine 5 5 The effects of preoperative exercise therapy on postoperative outcome: a systematic review. Clin Rehabil Surgery - General 6 5 Hospital Doctor/Hospitalists 5 4 Internal Medicine 5 4 Intermittent theta-burst transcranial magnetic stimulation for treatment of Parkinson disease. Neurology Neurology 4 4 Prehospital Intravenous Fluid Administration is Associated With Higher Mortality in Trauma Patients: A National Trauma Data Bank Analysis. Ann Surg Surgery - General 5 4 Intensivist/Critical Care 3 3 Efficacy of insulin analogs in achieving the hemoglobin A1c target of 7% in type 2 diabetes: meta-analysis of randomized controlled trials. Diabetes Care Endocrine 7 5 General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Internal Medicine 6 4 The combination of ribavirin and peginterferon is superior to peginterferon and placebo for children and adolescents with chronic hepatitis C. Gastroenterology Pediatrics (General) 6 7 Telaprevir is effective given every 8 or 12 hours with ribavirin and peginterferon alfa-2a or -2b to patients with chronic hepatitis C. Gastroenterology Gastroenterology 6 6 Infectious Disease 5 6
Article Title Discipline Rele- vance News- worthiness Complications after minimally invasive total knee arthroplasty as compared with traditional incision techniques: a meta-analysis. J Arthroplasty Surgery - Orthopaedics 6 6 Impact of soluble fms-like tyrosine kinase-1 and placental growth factor serum levels for risk stratification and early diagnosis in patients with suspected acute myocardial infarction. Eur Heart J Emergency Medicine 5 4 Edaravone for acute intracerebral haemorrhage. Cochrane Database Syst Rev Emergency Medicine 4 4 Zinc for the common cold. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Pediatrics (General) 5 4 Comparison of positive lymph node ratio with an inflammation-based prognostic score in colorectal cancer. Br J Surg Oncology - Gastrointestinal 7 6 Quality of diabetes care predicts the development of cardiovascular events: results of the AMD-QUASAR study. Diabetes Care General Practice(GP)/Family Practice(FP) 5 6 General Internal Medicine-Primary Care(US) 5 6 Nitric oxide for inhalation in the acute treatment of sickle cell pain crisis: a randomized controlled trial. JAMA Special Interest - Pain -- Physician 5 5 Adverse effects of biologics: a network meta-analysis and Cochrane overview. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 A Cochrane review of combined chiropractic interventions for low-back pain. Spine General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Rheumatology 5 4 ``Triple therapy`` rather than ``triple threat``: a meta-analysis of the two antithrombotic regimens after stent implantation in patients receiving long-term oral anticoagulant treatment. Chest Hematology/Thrombosis 5 5 The risk of hypotension following co-prescription of macrolide antibiotics and calcium-channel blockers. CMAJ General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6 Internal Medicine 6 5 Infectious Disease 5 5 Very early hypothermia induction in patients with severe brain injury (the National Acute Brain Injury Study: Hypothermia II): a randomised trial. Lancet Neurol Emergency Medicine 6 6 Pediatric Emergency Medicine 6 5 Clinical practice guidelines for the use of noninvasive positive-pressure ventilation and noninvasive continuous positive airway pressure in the acute care setting. CMAJ Intensivist/Critical Care 7 4 Hospital Doctor/Hospitalists 6 6 Internal Medicine 6 6 Emergency Medicine 6 4 A systematic review of randomised controlled trials of the effects of warmed irrigation fluid on core body temperature during endoscopic surgeries. J Clin Nurs Surgery - General 5 4 Internal Medicine 4 3 International comparison of clinicians` ability to identify depression in primary care: meta-analysis and meta-regression of predictors. Br J Gen Pract General Practice(GP)/Family Practice(FP) 4 5 General Internal Medicine-Primary Care(US) 4 5
Article Title Discipline Rele- vance News- worthiness Topotecan Weekly Versus Conventional 5-Day Schedule in Patients With Platinum-Resistant Ovarian Cancer: a randomized multicenter phase II trial of the North-Eastern German Society of Gynecological Oncology Ovarian Cancer Study Group. J Clin Oncol Oncology - Gynecology 6 5 Knee arthroplasty with a medially conforming ball-and-socket tibiofemoral articulation provides better function. Clin Orthop Relat Res Surgery - Orthopaedics 7 7 Wireless pulmonary artery haemodynamic monitoring in chronic heart failure: a randomised controlled trial. Lancet Cardiology 6 7 Treatment for ulnar neuropathy at the elbow. Cochrane Database Syst Rev Physical Medicine and Rehabilitation 6 6 Surgery - Neurosurgery 5 4 Usefulness of the myocardial performance index determined by tissue Doppler imaging m-mode for predicting mortality in the general population. Am J Cardiol General Practice(GP)/Family Practice(FP) 5 3 General Internal Medicine-Primary Care(US) 5 3 Cardiology 4 6 Strategies for the withdrawal of nasal continuous positive airway pressure (NCPAP) in preterm infants. Cochrane Database Syst Rev Pediatric Neonatology 6 5 Cardiac Resynchronization Therapy Is More Effective in Women Than in Men The MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy) Trial. J Am Coll Cardiol Cardiology 6 6 Surgery - Cardiac 5 6 Antidepressants for agitation and psychosis in dementia. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Improved glycemic control without hypoglycemia in elderly diabetic patients using the ubiquitous healthcare service, a new medical information system. Diabetes Care Geriatrics 6 5 General Practice(GP)/Family Practice(FP) 5 3 General Internal Medicine-Primary Care(US) 5 3 Intermittent pneumatic compression for treating venous leg ulcers. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 5 6 General Internal Medicine-Primary Care(US) 5 6 Surgery - Plastic 5 4 A comparison of active management and expectant management of the third stage of labour: a Swedish randomised controlled trial. BJOG GP/FP/Obstetrics 6 4 Trimetazidine: a meta-analysis of randomised controlled trials in heart failure. Heart Cardiology 5 5 Food supplements for body weight reduction: a systematic review of systematic reviews. Obesity (Silver Spring) General Practice(GP)/Family Practice(FP) 5 4 General Internal Medicine-Primary Care(US) 5 4 Vitamin E for neuroleptic-induced tardive dyskinesia. Cochrane Database Syst Rev Psychiatry 6 4 Continuous support for women during childbirth. Cochrane Database Syst Rev GP/FP/Obstetrics 7 4 Improved corticosteroid treatment of recalcitrant de quervain tenosynovitis with a novel 4-point injection technique. Am J Sports Med Rheumatology 6 5 Diuretic strategies in patients with acute decompensated heart failure. N Engl J Med Hospital Doctor/Hospitalists 7 7 Internal Medicine 7 7 Cardiology 6 5
经典分类学的时代契合——纪念林奈诞辰300周年 何家庆 自1735年《自然系统》(Systema Naturae)一书出版始,自然科学有了经典的分类学。该书作者林奈(C.von Linné)的贡献在于,建立了人为分类体系和双名法则。《自然系统》的内容涉及植物、动物、矿物,历经270多年使用至今。 林奈生平与分类学史 15—17世纪的地理大发现,让欧洲人开阔了视野。许多学者从亚洲、非洲和美洲各地采集了大量植物、动物及矿物标本运至欧洲。因没有一个统一的命名规则,采集者仅根据自己的喜好来取名或描述所发现的东西,致使研究工作困难重重,突出反映在三个方面:(1)命名上出现同物异名、异物同名的混乱现象;(2)动植物名冗长;(3)语言、文字上的隔阂与混乱。时至1600年,植物学家们大约了解6000种植物,100年后,又发现了12 000个新种。到18世纪,在那个生物学信息空乏的时代,研究者们渴望解决问题的途径,对生物物种进行科学的分类变得极为迫切。 在这种历史背景下,在瑞典南部斯莫兰省斯腾布罗胡尔特教区的南雷舍尔特村,林奈(1707—1778年)出生了。他的父亲N.林奈(N.Linnaeus)是个路德派乡村牧师,极爱好园艺,善于管理花草树木,他的园圃是全瑞典收集植物种类最多的园圃之一。母亲布罗德森(C.Brodersonius)也是个牧师的女儿。林奈自幼对其父母让他继承父亲和外公做教士的愿望极不感兴趣,但却受到父亲业余爱好的影响,对花草树木有着异乎寻常的爱好。他把大部分时间和精力用于在野外采集各种植物、动物和矿物标本,以及阅读植物学著作。小时候的林奈在校成绩总体较差,虽然生物学、逻辑学的成绩表现突出,但其他科目只处于中等偏下的水平甚至不及格,因而被迫退学。林奈对上学的印象是:“处罚,不断地被处罚,教室是最令人坐立不安的地方……如果能够有间教室,是在森林中漫步,是在小草中打滚,不知道有多好!”他在植物学方面的兴趣和知识引起了罗特曼(J.Rothman)博士的注意。在这位老师的劝说和努力之下,1727年其父以仅有的40克朗将林奈送到隆德大学。一年后林奈转入乌普萨拉大学。林奈在乌普萨拉大学医学院学习,但他仍无法改变致力于植物学的兴趣。 1730年他曾在《植物婚配论》一文中将植物的雄蕊和雌蕊比拟为一对夫妻,生动有趣地描述植物的繁殖过程,因此受到学者们的好评。不久,林奈通过自己的观察与研究给出了“植物性别”的概念,在当时科学界也是对植物研究的重要贡献之一。1731年,林奈出版《植物辞典》(Botanical Dictionary)。1732年获得乌普萨拉科学院资助,随探险队到瑞典北部拉普兰地区野外考察,在方圆4600平方英里(约7400平方公里)的荒凉地带,他发现了100多种新植物,调查结果发表在他的《拉普兰植物志》(Flora Lapponica)上。1735年7月,他在荷兰哈德维克大学以《间歇热病因新论》的学位论文获得医学博士学位,后去德、法、英等国旅行考察,结识了许多第一流科学家,并得到了原本在国内所没有的一些植物标本。 在国外的三年是林奈一生中最重要的时期,是他学术思想成熟、初露锋芒的阶段。在荷兰期间他完成了不少重要著作,著名的《自然系统》一书就是在此期间著成的。尽管该书当时只有14页,但首先提出了以植物的生殖器官进行分类的方法。到1758年,该书第10版计1384页,为4235种动物命名,无疑已经成为一部巨著。1737年《植物的属》(Genera of Plants)出版。1738年10月,林奈返回祖国,定居于斯德哥尔摩,并回到母校乌普萨拉大学任解剖学、植物学、药物学、博物学教授,他重建了该校植物园,栽培植物达1600种。1739年,他与一位著名医生的女儿伊利莎白(S. Elisabeth)结婚,以行医与教学为生。两年后,他在乌普萨拉大学获得一个医学教授职位,但他很快就将这个职位转换成了一个植物学教授职位。 1751年,林奈的《植物哲学》(Philosophia Botanica)出版,这是他最有影响的工作。书中阐述分类的自然系统源于上帝的创造,并永远不变。在书中,作者证明了植物的有性繁殖现象,并依雄蕊和雌蕊的类型、大小、数量及相互排列等特征,将植物分为纲、目、属和种等分类阶元。这些不同层次的分类概念是林奈的首创。他采用拉丁文双名制(binomial nomenclature)命名法定植物学名。拉丁文是当时欧洲知识界流行的书面文字,变化少,比用英、法等文字记述物种更容易被各国科学家接受。用拉丁文给不同物种定名,并要求在使用诸如希腊文或其他文字时先把它们拉丁化。这一创举强制了物种名称的统一,便于交流,有利于学术发展。1753年,林奈出版《植物种志》(Species Plantarum),该书从1746年开始写作,1752年脱稿,历时7年。书中使用双命名法给7300种左右的植物命名。 由于大量的野外调查与整理工作,林奈认识到:“知识的第一步,就是要了解事物本身。这意味着对客观事物要具有确切的理解;通过有条理的分类和确切的命名,我们可在认识客观物体时将其区分开来……分类和命名是科学的基础。”林奈能产生这样的真知灼见,还在于他重视研究与总结前人的工作,虚心汲取前人之长并加以发展。如在1729年,林奈读到一位法国植物学家著的《花草的结构》一书受到启发,嗣后,他根据植物的雌蕊和雄蕊的数目进行植物分类。其实,早在古希腊时期的亚里士多德所建立的动植物命名法已具有双名制法则的萌芽,只是到了林奈才将双名制加以完善和推广。他感叹自己建立的分类体系是“上帝创造,林奈整理”。确切地说林奈不是双名法首创人,但可以肯定,他完善了物种命名法则,使之标准化并被各国生物学家所接受,植物界的混乱局面也因此被他的命名法则调理得井然有序。他的工作促进了植物学的发展,林奈无愧是近代分类学的奠基人。 林奈一生所从事的自然科学研究很广泛,对植物分类学、动物分类学、昆虫学、医学及矿物学都做过大量研究,收集的植物标本达14 000号,昆虫标本7000号,很多动、植物都是林奈第一次命名的。他根据植物花的特征,把植物分为24纲、116目、1000多属和1万多种。如此浩瀚的科学工程由他独自一人完成,所以人们称呼他为“植物学之王”。对于动物分类,林奈也很有建树,他把动物分成6个纲,即四足动物纲、鸟纲、两栖动物纲、鱼纲、昆虫纲和蠕虫纲。将鲸、人、大猩猩、猴等都列入四足动物纲,这就是后来人们所说的哺乳动物纲。 他认为物种是真实存在的,并可以归入被称为属的更高分类阶元。由此,他建立的分类系统以属作为分类基础,把向下分类法严格限制在属的水平。他强调的是“发现”属而不是“设置”属。林奈在确定属时,首先根据植物的外形,随后再详述其本质。属就最好不过地代表了他的本质论思想,一切的属都被严格的不连续性分隔开。因此,他划分的许多属符合自然分类。现代分类学家把属看作是最低级的集合阶元,是具有某些共同性质的种的集群。这并不是遵循逻辑分类的早期关于属的概念。他们认为属是具有一定本质并可依据特异性划分成种的一个独立阶元。 由于林奈生活在“神创论”占支配地位的时代,他的分类方法必然受到流行的“物种不变论”思想的影响。他曾说,混沌初开时,万能的神创造了多少物种,到现在就还有多少物种。对于不同的物种,林奈不持生物进化观念,他认为物种不会改变,物种彼此之间不存在亲缘关系,因此他的分类系统是不能反映不同生物类群在进化上的地位的人为分类系统。到了晚年,林奈对物种不变的信念有所动摇,在1768年出版的《自然系统》第12版中,他删去了有关物种不变的论述。另一方面,他鉴定物种所选用的性状大多是有同源关系的,是可以比较的,因此他的分类系统至今仍是有意义的,给生物所定的名称至今大多也仍是有效的。林奈一方面是经院哲学逻辑的追随者和坚定的本质论者,另一方面他又承认强调连续性的完满原则(Principle of Plenitude)。他发现,许多生物之间有从属的关系,因此他首先将自然物分成三个界;在界的下面,是如阶梯般排列的5个阶元:纲、目、属、种、变种。林奈将世界上的所有生物(甚至包括矿物)统一在自己的分类体系之中,建立了经典分类科学。 林奈给出的分类学阶元属、目、纲、界的定义完全是他独自完成的。他采用这些高级阶元好像不是为了学术原因而完全出于实际理由。他曾说纲和目不如属那样“自然”。他在《植物哲学》中写道:“纲是几个属在它们的结实(fruitifications)方面按自然和艺术原则取得的一致……目是为了防止把超过易于处理的许多属放在一起而将纲再细分一次。”可见林奈的纲在一定程度上是人为的,但是他又暗示当植物所有的属都被发现并描述之后它们将会被“自然纲”代替,“目”则更是为了选择方便。对林奈来说,很明显高级阶元只是一个方便的信息检索器。 林奈一生出版著作多达180余部,对后世影响很大的有《自然系统》、《植物哲学》、《植物学基础》、《性别分类法》、《植物种志》和《植物属志》。他不仅认真从事科学研究,还是一位不容忽视的教育家。林奈知识广博,他还编写了一部有关瑞典民俗、重点介绍瑞典民间舞蹈的书籍,为民俗学研究作出贡献。他对生物地理学和生态学也给予广泛关注。他讲课生动且富于幽默感,来自对大自然广泛观察和深邃思考之后的见解颇为新颖,因而吸引了大批学生听他的课。在乌普萨拉大学,每次听他课的学生多达200~400人,还有许多校外学生,不少是来自欧洲各国的学生。 鉴于他的学术成就与贡献,林奈生前获得了极高奖赏,如瑞典国王于1757年授予他骑士的贵族头衔。1761年林奈退休,他的姓氏也由平民的Linneaus改为贵族的von Linné。 分 类 学 现 状 分类学家认为分类学的发展可分为两个时期:林奈以前的时期,人为地根据植物的用途或一个至几个明显的形态特征进行描述分类,称为人为分类;林奈以后的时期,依据最能反映不同植物类群之间亲缘关系和系统演化的主要性状进行分类,称为自然分类。通过长期不懈的努力,至今对自然界已知物种数目的统计约在140万~180万种,其中每个类群已被记录的数目与估计数目都有一定差距。 已被鉴定和描述的物种大多数为昆虫和高等植物,大量的昆虫、蜘蛛、线虫、藻类、细菌、病毒和真菌尚未被描述,而且定名种的最终数目可能达到500万种或更多。 研究生物学所涉及的首要问题,在于正确阐明每一种被研究对象的系统位置,明确它与其他物种的亲缘关系。经典分类学以植物体的形态特征,尤其是花部的特征为分类基础,所获得的上述结果不仅局限于鉴定物种,确定其等级,建成分类系统,而且还用于研究植物种间亲缘关系及整个生物界系统发育的演化过程,使人们对分类学的概念从静态的创造论转变为动态的进化论。 在宏观植物学领域,分类学不仅建立起一个个植物自然进化系统,还一直活跃在生态系统学研究领域,如今已经应用于关注生物丰富度的生物多样性研究,鉴定大量从野外采集的物种标本,实现对群落生态学的研究,阐述环境变化与植物之间的相互关系。试想没有明确的物种基础知识,这些相关研究会处在何等窘迫的状态! 分类学的发展 生物分类的习惯是根据个别的模式标本作为种的鉴定,因而把个体当作基本的分类单位。1940年代赫胥黎(J.Huxley)在他的《新系统学》中,以种群分类概念代替模式分类概念,使分类学除用形态特征作为分类性状外,还引入了生态、行为、生理、生化、地理等方面的资料作为分类依据,以生物学概念替代纯形态概念。 1963年斯尼兹(P.Sneath)和索卡尔(R.Sokal)联合出版《数值分类学原理》,提出用数学方法来划分种和高级阶元。对所研究的生物类群的许多性状加以数值化,再用计算机运算、对比和统计分析,根据它们之间的相似程度来分类。 应用细胞学特征进行染色体核型分析,如其数目、形态和大小,染色体的类别,染色体着丝粒的位置及其臂长,染色体的带型(染色体经染色在一定部位显示出不同的条带)等特征,被称为细胞分类学(cytotaxonomy)。 蛋白质电泳分析技术已成为现代分类学的标志之一。分子生物学家发现,两个物种的蛋白质分子长链的氨基酸排列相同的部分愈多,它们之间的差异就愈少,其亲缘关系也愈近。将待检物种的提取液进行聚丙烯酰胺凝胶电泳或淀粉凝胶电泳,或等电点聚焦电泳,用溴酚蓝等蛋白质染色剂染色,得出条带电泳图。计算样品中相同移动率的条带数与最大条带数之间的比值,得出物种的相似系数。 在生物大分子水平上比较细胞色素c(具有104~112个氨基酸的多肽分子)。从进化角度看,细胞色素c是很保守的分子。据估计, 它的氨基酸顺序每200万年才发生1%的改变。不同生物的细胞色素c中氨基酸的组成和顺序反映了这些生物之间的亲缘关系。 从描述生物学发展到分子生物学,生物学的信息浩瀚如海地涌来,进一步敦促经典分类学在前期积累的基础上继续发展。瑞典林奈学会的雅可布松(C.O. Jacobson)在纪念林奈诞辰300周年的庆祝活动结束时介绍说:“林奈依然不会过时,原因不光在于他的林奈双名命名体系。林奈认为,人类对其生活的世界负有责任,人类是整个世界平等的一部分,而不能主宰世界。因此,在气候转变的时代,林奈也可以被看作是环境保护的思想先驱。” 分类学是千万不能在信息时代落伍的。自然科学中的每一门学科都以能最有效地衔接大众为其成功与价值的标志之一,分类学亦不例外。20世纪中期遗传物质DNA的结构被揭示,生命科学的研究拉开了新序幕,也给分类学注入了活力。嗣后,研究者建立起以鸟类DNA相似度为基础的系统树。由此,物种测序研究也进入高潮。事实说明分子生物学技术是经典分类学研究的“提速器”,能用于更加精确地验证物种间的系统特征。以标本为分类依据的研究,只能从形态上“推测”物种间的亲缘关系,“可能”与“不可能”同时存在;采用生化、遗传、生理等实验方法才有可能确定,然而需要克服耗时较长的弱点。分子生物学技术的引入点明了分类学的时代特征,近期有人提出用DNA区分不同物种的方法。赫伯特(P.Hebert)采用了一种特定的基因片段(类似条码)来分类各种生物,而不需要测定整个基因组的序列。这个“条码”基因会反映出不同物种的COI(细胞色素c氧化酶),基因“条码”就应该有所不同。尽管目前COI基因仍不能完全把不同种的植物或动物区分开,但能做到让大家都来参与,即便是外行也可以通过小型的DNA条码“扫描”装置来鉴定物种。分类学只有伴随时代发展引入新思路和技术并予以传播,才能形成该学科未来发展的动力。 在林奈诞辰300周年之际,各国植物学家高度关注如今的分类学能不能与网络时代契合,这对该学科的未来非常关键。在已经获得大量信息的基础上,整理所有已知植物类群的信息,诸如形态学、发育生物学、生态学、环境适应与胁迫、种群动态及其资源价值等,将已知的各类相关信息整合到诸如DNA序列测定的新技术中来。这样是否能最终实现如同扫描条码一样鉴定不同的物种呢? 胡先骕. 卡尔 · 林奈对近代植物分类学的贡献. 科学史集刊,1958,(1):15. 汪振儒. 卡尔·林奈事略. 科学史集刊,1958,(1):10. Takhtajan A. Diversity and Classification of Flowering Plants. New York:Columbia University Press,1997. Cronquist A. An Intrgrated System of Classification of Flowering Plants. New York: Columbia University Press,1981. Godfray H C J. Linnaeus in the information age. Nature, 2007,446:259. Knapp S. Spreading the word. Nature,2007,446:261. Prusinkiewicz P,et al. Evolution and development of inflorescence architectures. Science,2007,316:1452.
Article Title Discipline Rele- vance News- worthiness Comparison of Sirolimus with Azathioprine in a Tacrolimus-based Immunosuppressive Regimen in Lung Transplantation. Am J Respir Crit Care Med Surgery - Thoracic 5 4 Bisphosphonate use and the risk of subtrochanteric or femoral shaft fractures in older women. JAMA Geriatrics 7 6 Psychological interventions for treatment of inflammatory bowel disease. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 5 4 General Internal Medicine-Primary Care(US) 5 4 Thoracic epidural anesthesia for cardiac surgery: a randomized trial. Anesthesiology Surgery - Cardiac 6 5 Feeding interventions for growth and development in infants with cleft lip, cleft palate or cleft lip and palate. Cochrane Database Syst Rev Pediatric Neonatology 6 5 Congestive heart failure risk in patients with breast cancer treated with bevacizumab. J Clin Oncol Oncology - Breast 5 5 Shengmai (a traditional Chinese herbal medicine) for heart failure. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 4 4 General Internal Medicine-Primary Care(US) 4 4 Cardiology 3 3 Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial. Lancet Oncol Surgery - Head and Neck 7 5 Induction chemotherapy with cisplatin and fluorouracil alone or in combination with docetaxel in locally advanced squamous-cell cancer of the head and neck: long-term results of the TAX 324 randomised phase 3 trial. Lancet Oncol Surgery - Head and Neck 6 6 Antihypertensive Treatment and Secondary Prevention of Cardiovascular Disease Events Among Persons Without Hypertension: A Meta-analysis. JAMA Hospital Doctor/Hospitalists 7 6 Internal Medicine 7 6 Cardiology 5 4
To view this email in your browser: www.the-scientist.com/daily1/2011/03/02/ 02 March 2011 News and Features The latest in biology and medicine Best Places to Work for Postdocs, 2011 Setting up your own lab is no easy task, but this year’s respondents are using their postdoc experiences to prepare for the challenge By Cristina Luiggi Behavior brief A round up of recent discoveries in behavior research By Jef Akst Editor's choice in immunology Researchers discover a mechanism of antibody action that works inside cells, providing a "last line of defense" against infection By Richard P. Grant Fig share Mark Hahnel, a PhD student at Imperial College London, describes a new scientific figure-sharing site he released in beta today By Richard P. Grant New mechanism for dementia? The voracious clearing of injured and dying cells that could have otherwise recovered may contribute to neurodegenerative disease By Cristina Luiggi Eye evolution questioned Invertebrates with vertebrate-like vision challenge the idea that the two groups of organisms have distinctly different visual receptors By Amy Maxmen Top 7 in molecular biology A snapshot of the most highly ranked articles in molecular biology and related areas, from Faculty of 1000 By Megan Scudellari News in a nutshell Postdoc protests; cell phone disturbs brain; Japanese university unrest By Jef Akst Capsule reviews A selection of top-notch science books By Bob Grant The forum Dip into The Scientist's mailbag to see what readers are saying about recent stories By The Scientist Staff Mad science? A documentary about the research of neuroscientist Robert White goes beyond his macabre head-transplant experiments to highlight his contributions to science By Hannah Waters Puzzle me this Why are placebos so mysterious? By Graeme Stemp-Morlock The evolution of credibility A new book on the practice of science explores the winding path of discovery, and much more By Frederick Grinnell
Article Title Discipline Rele- vance News- worthiness Single or double-level anterior interbody fusion techniques for cervical degenerative disc disease. Cochrane Database Syst Rev Surgery - Orthopaedics 5 4 The effect of melatonin, magnesium, and zinc on primary insomnia in long-term care facility residents in Italy: a double-blind, placebo-controlled clinical trial. J Am Geriatr Soc General Practice(GP)/Family Practice(FP) 5 4 General Internal Medicine-Primary Care(US) 5 4 Rifaximin Improves Psychometric Performance and Health-Related Quality of Life in Patients With Minimal Hepatic Encephalopathy (The RIME Trial). Am J Gastroenterol General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Interventions to enhance return-to-work for cancer patients. Cochrane Database Syst Rev GP/FP/Mental Health 4 5 Oncology - Genitourinary 4 5 Evaluation of the diagnostic and prognostic value of plasma D-dimer for abdominal aortic aneurysm. Eur Heart J Surgery - Vascular 5 7 Noninvasive ventilation for respiratory distress syndrome: a randomized controlled trial. Pediatrics Pediatric Neonatology 6 6 Respirology/Pulmonology 5 5 Transparent cap colonoscopy versus standard colonoscopy for investigation of gastrointestinal tract conditions. Cochrane Database Syst Rev Oncology - Gastrointestinal 5 4 Gastroenterology 4 3 Identification of Patients With Acute Myeloblastic Leukemia Who Benefit From the Addition of Gemtuzumab Ozogamicin: Results of the MRC AML15 Trial. J Clin Oncol Oncology - Pediatric 6 6 Randomized study of basal-bolus insulin therapy in the inpatient management of patients with type 2 diabetes undergoing general surgery (RABBIT 2 surgery). Diabetes Care Hospital Doctor/Hospitalists 6 5 Internal Medicine 6 5 Endocrine 6 5 Effects of n-3 Polyunsaturated Fatty Acids on Left Ventricular Function and Functional Capacity in Patients With Dilated Cardiomyopathy. J Am Coll Cardiol Cardiology 6 6
The UCMP website contains thousands of pages of content about the history of life on Earth. Our main exhibit sections include: History of life through time This enormous collection catalogs life on Earth, focusing on the ancestor/descendant relationships which connect all organisms, past and present. Tour of geologic time Journey through geologic time to see how the Earth has changed since its debut 4.5 billion years ago. Understanding Evolution The Understanding Evolution site includes discussion of evolutionary theory, evidence for evolution, the relevance of evolution to our daily lives, and the history of evolutionary thought. The Paleontology Portal The Paleontolgy Portal focuses on the fossil record of North America, including state-by-state U.S. paleontology, fossil photo galleries, and resources for the North American paleontologist community. Education resources Activities and lessons specifically for K-12 teachers/students, as well as information on paleontology education at Berkeley. Field notes Accounts from UCMP faculty curators, staff, and students of their adventures and findings in the field. Research profiles Take a look at some of the exciting work happening at UCMP. These profiles give a glimpse of science in action. The world's biomes Explore our planet's biomes — environmental divisions defined by the community of organisms adapted to live within them. This includes forest, desert, tundra and more. Mystery fossil Perhaps it was photographed from a different viewpoint or from up close. Maybe it's odd-looking or simply uncommon. Can you identify the monthly mystery fossil? Special exhibits A collection of miscellaneous exhibits that UCMP has put together over the years. Dinosaurs, coelacanths, mantis shrimp and more! http://www.ucmp.berkeley.edu/exhibits/index.php The mission of the University of California Museum of Paleontology is to investigate and promote the understanding of the history of life and the diversity of the Earth's biota through research and education.
February 17, 2011 Trading resistance via nanotubes? Bacteria may be able to exchange large molecules -- including those that confer antibiotic resistance -- via microscopic tubes, but some researchers are skeptical By Edyta Zielinska Contaminated genomes Human DNA sequences are found in nearly a quarter of the publically-available non-primate genomes, emphasizing the need for better quality control measures By Hannah Waters Light therapy, circa 1939 Before the damaging effects of UV radiation were widely appreciated, physicians saw the sun mostly as a source of healing By Cristina Luiggi Nothing new on the grasslands To understand biodiversity and its effects on the environment we can’t simply measure single, key ecosystem functions By Richard P. Grant Opinion: When the wells run dry The practice and funding of science may change drastically when humanity enters an era of energy crisis, in which cheap oil is but a distant memory By John Day Impure genius Lewis Cantley has made a career of turning chemical contaminants into groundbreaking discoveries By Karen Hopkin Top 7 from F1000 A snapshot of the highest-ranked articles from a 30-day period on Faculty of 1000 By Megan Scudellari Skin wounds trigger tumors Researchers show how stem cells in hair follicles can transform into cancer while helping to heal an injury By Carrie Arnold Top 7 in cell biology A snapshot of the most highly ranked articles in cell biology and related areas, from Faculty of 1000 By Bob Grant Scientist to watch Anne-Claude Gingras: perfecting proteomics By Jef Akst The mouse is not enough Early embryonic development differs between mice and cows, suggesting mice may not reflect mammalian development as well as scientists had believed By Hannah Waters News in a nutshell Publically funded drugs; misconduct closure; shrunken brains at Chernobyl By Megan Scudellari Genome digest Meet the species whose DNA has recently been sequenced By Hannah Waters
February 16, 2011 Opinion: When the wells run dry The practice and funding of science may change drastically when humanity enters an era of energy crisis, in which cheap oil is but a distant memory By John Day Impure genius Lewis Cantley has made a career of turning chemical contaminants into groundbreaking discoveries By Karen Hopkin Top 7 from F1000 A snapshot of the highest-ranked articles from a 30-day period on Faculty of 1000 By Megan Scudellari How to handle dwindling funds Cutting costs can kill employee morale; those who invest in long-term income will emerge as the winners By Morgan Giddings Skin wounds trigger tumors Researchers show how stem cells in hair follicles can transform into cancer while helping to heal an injury By Carrie Arnold Top 7 in cell biology A snapshot of the most highly ranked articles in cell biology and related areas, from Faculty of 1000 By Bob Grant Scientist to watch Anne-Claude Gingras: perfecting proteomics By Jef Akst The mouse is not enough Early embryonic development differs between mice and cows, suggesting mice may not reflect mammalian development as well as scientists had believed By Hannah Waters News in a nutshell Publically funded drugs; misconduct closure; shrunken brains at Chernobyl By Megan Scudellari Genome digest Meet the species whose DNA has recently been sequenced By Hannah Waters Researchers are punks The fields of science and punk rock share some surprising similarities, according to the people who love both By Alison McCook Cellular chaos fights infection Blocking RNA degradation in bacteria could help treat Staph infections by overcrowding the microbe with a surplus of transcripts By Hannah Waters Cell division with a twist Scientists discover a key mechanism in the final stages of human cell division By Megan Scudellari
Two-faced proteins? Proteins that both hinder and spur cancer progression may not be as uncommon as previously thought Opinion: Training home and away China’s graduate stipend programs offer great opportunities for students and host institutions, but some of the programs’ publication requirements may need amending Gene swap key to evolution Horizontal gene transfer accounts for the majority of prokaryotic protein evolution The iPSC-ESC gap Human cells reprogrammed into multipotent stem cells display fundamental differences from true embryonic stem cells New mosquito identified With distinct genetics and behavior, a novel subgroup of mosquitoes encourages scientists to rethink the fight against malaria Gut microbes influence behavior Mice lacking normal gut bacteria show differences in brain development and behavior New circadian timer? A metabolic pathway that maintains its own 24-hour cycle challenges the traditional view of a purely transcription-driven biological clock Opinion: Torments of tagging Is marking the wild animals we study skewing our results? And if so, what can we do about it? Amoeba agriculture Some slime molds transport and farm the bacteria they eat Model worm susceptible to virus Researchers discover the first virus that can infect Caenorhabditis elegans Fighting noise with noise Pairing tones with electrical stimulation of the brain may reverse the constant ringing caused by exposure to loud sound Cancer pilfers cell powerhouse An atypical form of contagious canine cancer may steal its host’s mitochondria when its own succumb to DNA damage Above a troubled planet A film that takes a bird’s eye view on the effects of climate change debuts in the United States New metastasis marker found A new molecular predictor of cancer-spread adds to a growing list of biomarkers that could improve treatment QA: Alzheimer’s trial disconnect While preclinical studies identify ways to prevent Alzheimer’s disease in animals, human trials test these same therapies in symptomatic patients—long after they are most likely to be effective
Cover story: Face to Face with the Emotional Brain Amygdala responses to the facial signals of others predict both normal and abnormal emotional states. BY AHMAD R. HARIRI AND PAUL J. WHALEN The Genes of Parkinson’s Disease The minority of Parkinson’s cases now known to have genetic origins are shedding light on the cellular mechanisms of all the rest. BY BOBBY THOMAS AND M. FLINT BEAL Opening a Can of Worms A father’s determination to help his son resulted in an experimental treatment for autism that uses roundworms to modulate inflammatory immune responses. BY BOB GRANT To Err is Human This is your brain on emotions. BY SARAH GREENE Do Fruit Flies Dream of Electric Bananas? Visualizing neuronal activity in small brains over four dimensions BY BJRN BREMBS At the Tipping Point Data standards need to be introduced—now. BY H. STEVEN WILEY Impure Genius Lewis Cantley has made a career of turning chemical contaminants into groundbreaking discoveries—including novel lipids, potent inhibitors, and kinases involved in cancer. BY KAREN HOPKIN The Evolution of Credibility The winding path that an interesting result takes to become a bona fide discovery is just one of the topics covered in this new book on the practice of science. BY FREDERICK GRINNELL When Stress Is Good Fast blood flow protects against atherosclerosis: implications for treatment. BY CHRISTINA M. WARBOYS, NARGES AMINI, AMALIA DE LUCA, AND PAUL C. EVANS One on One: Parasites Unite! Gabriele Sorci discusses how invaders can band together to more effectively infect hosts. BY CRISTINA LUIGGI F1000 Hidden Jewel: Down but Not Out Cells on standby are surprisingly busy. BY RICHARD P. GRANT
Scientific smear campaign? An anonymous agitator upsets a German misconduct investigation Opinion: 6 impossible things Why biomedical research is stressful, and how it can be slightly less so Normal today, cancer tomorrow Researchers discover how cancer can develop overnight Arctic mismatch threat? A new report suggests that hybridization between species may put future Arctic populations at risk Opinion: Success! The astonishing secret to getting jobs, grants, papers, and happiness in biomedical research New gut bacteria regulate immunity A commensal microbe that affects host immunity may hold implications for treating autoimmune diseases Fewer mutations in kids’ cancer The first genetic map of pediatric cancer reveals important differences from adult tumors Model organisms up close New research from the frontlines of the modENCODE Project reveals the most comprehensive genomic picture of the worm and the fruit fly Tears dampen arousal Women’s tears contain a chemical signal that reduces men’s sexual excitement Malaria parasites synch with host Plasmodium microbes that cause malaria coordinate with the internal clocks of their hosts to increase their chances of survival New compound disrupts clock A high-throughput chemical screen could identify new drug candidates for circadian diseases Opinion: 5 ways to save antibiotics Here’s what we need to do to create new antibiotics and extend the life of those that already exist African elephants: 2 for 1 deal Savanna and forest elephants in Africa are two distinct species, according to new genetic data, settling a long-standing controversy Musical pleasure Drugs, sex, and food aren’t the only sources of pleasure—music activates the brain’s reward circuitry as well Behavior brief A round up of recent discoveries in behavior research