2010年 1.Yin K, Liao D, Tang CK(通讯作者). ATP-Binding Membrane Cassette Transporter A1 (ABCA1): A Possible Link between Inflammation and Reverse Cholesterol Transport. Mol Med. 2010, 16 (9-10): 438-449. (IF: 5.02). 2.Hu YW, Wang Q, Ma X, Li XX, Liu XH, Xiao J, Liao DF, Xiang J, Tang CK(通讯作者).TGF-beta1 Up-Regulates Expression of ABCA1, ABCG1 and SR-BI through Liver X Receptor alpha Signaling Pathway in THP-1 Macrophage-Derived Foam Cells. J Atheroscler Thromb. 2010, 17(5): 493-502. (IF: 3.048). 3.Liu XH, Xiao J, Mo ZC, Yin K, Jiang J, Cui LB, Tan CZ, Tang YL, Liao DF, Tang CK(通讯作者). Contribution of D4-F to ABCA1 Expression and Cholesterol Efflux in THP-1 Macrophage-Derived Foam Cells. J Cardiovasc Pharmacol. 2010, 56(3):309-19. ( IF:2.826) 4.Chen SG, Xiao J, Liu XH, Liu MM, Mo ZC, Yin K, Zhao GJ, Jiang J, Cui LB, Tan CZ, Yin WD, Tang CK(通讯作者). Ibrolipim increases ABCA1/G1 expression by the LXRα signaling pathway in THP-1 macrophage-derived foam cells. Acta Pharmacol Sin. 2010, 31(10):1343-9. (IF: 1.783). 5.Sun SW, Zu XY, Tuo QH, Chen LX, Lei XY, Li K, Tang CK(通讯作者), Liao Duan-fang(通讯作者).Caveolae and caveolin-1 mediate endocytosis and transcytosis of oxidized low density lipoprotein in endothelial cells. Acta Pharmacol Sin. 2010, 31 (10): 1336-42. (IF: 1.783). 6.Liu Q, Dai Z, Liu Z, Liu X, Tang C, Wang Z, Yi G, Liu L, Jiang Z, Yang Y, Yuan Z. Oxidized low-density lipoprotein activates adipophilin through ERK1/2 signal pathway in RAW264.7 cells . Acta Biochim Biophys Sin (Shanghai),2010, 42(9):635-645. 7.Qinkai Li, Weidong Yin(Corresponding author), Manbo Cai, Yi Liu, Hongjie Hou, Qingyun Shen, Chi Zhang, Junxia Xiao, Xiaobo Hu, Qishisan Wu, Makoto Funaki, and Yutaka Nakaya. NO-1886 suppresses diet-induced insulin resistance and cholesterol accumulation through STAT5-dependent upregulation of IGF1 and CYP7A1. J. Endocrinol., Jan 2010; 204: 47 - 56. 8. Lin J, Wang LY, Liu S, Wang XM, Yong Q, Yang Y, DU LP, Pan XD, Wang X, Jiang ZS.A novel mutation in proprotein convertase subtilisin/kexin type 9 gene leads to familial hypercholesterolemia in a Chinese family. Chin Med J (Engl). 2010 May;123(9):1133-8. 9.Hu B, He X, Li A, et al. Cystogenesis in ARPKD results from increased apoptosis in collecting duct epithelial cells of Pkhd1 mutant kidneys . Exp Cell Res, 2010. 10.曹冬黎，尹凯，莫中成，郝新瑞，胡炎伟，李晓旭，唐雅玲，唐朝克(通讯作者). 脂多糖通过核因子-κB途径下调泡沫细胞ABCA1的表达. 生物化学与生物物理学进展. 2010, 37 (5): 540-548. (IF: 0.193). 2009年 11.Jiang ZS, Wen GB, Tang ZH, Srisakuldee W, Fandrich RR, Kardami E. High molecular weight FGF-2 promotes postconditioning-like cardioprotection linked to activation of the protein kinase C isoforms Akt and p70 S6 kinase. Can J Physiol Pharmocol, 2009, 87:1-7 12.Srisakuldee W, Jeyaraman MM, Nickel BE, Tanguy S, Jiang ZS, Kardami E. Phosphorylation of connexin-43 at serine 262 promotes a cardiac injury-resistant state. Cardiovasc Res. 2009，83 (4):672-81. 13.Feng X, Chen Y, Zhao J, Tang C, Jiang Z, Geng B. Hydrogen sulfide from adipose tissue is a novel insulin resistance regulator. Biochem Biophys Res Commun. 2009，380：153-159（通讯作者） 14.Hu YW, Ma X, Li XX, Liu XH, Xiao J, Mo ZC, Xiang J, Liao DF, Tang CK(通讯作者). Eicosapentaenoic acid reduces ABCA1 serine phosphorylation and impairs ABCA1- dependent cholesterol efflux through cyclic AMP/protein kinase A signaling pathway in THP-1 macrophage-derived foam cells. Atherosclerosis. 2009, 204(2): e35-e43. (IF: 4.522). 15.Hao XR, Cao DL, Hu YW, Li XX, Liu XH, Xiao J, Liao DF, Xiang J, Tang CK(通讯作者). IFN-gamma down-regulates ABCA1 expression by inhibiting LXRalpha in a JAK/STAT signaling pathway-dependent manner. Atherosclerosis. 2009, 203(2): 417-428. ( IF:4.522) 16.Ma X, Hu YW, Mo ZC, Li XX, Liu XH, Xiao J, Yin WD, Liao DF, Tang CK(通讯作者). NO-1886 Up-regulates Niemann-Pick C1 Protein (NPC1) Expression Through Liver X Receptor alpha Signaling Pathway in THP-1 Macrophage-Derived Foam Cells. Cardiovasc Drugs Ther. 2009, 23(3): 199-206. (IF: 2.515) 17.Meihua She, Xiaojian Deng, Zhenyu Guo, Moshe Laudon, Zhuowei Hu, Duanfang Liao, Xiaobo Hu, Zehong Su,Weidong Yin. NEU-P11, a novel melatonin agonist, inhibits weight gain and improves insulin sensitivity in high-fat/high-sucrose-fed rats. Pharmacol Res 2009; 59(4) 248-253. 18.WEI Dang-heng, WANG Gui-xue, TANAG Chao-jun, LIU Lu-shang, WANG Zuo, TANG Chao-ke, RUAN Chang-geng. Effect of low density lipoprotein concentration polarization on endothelial cells adhesion. 2009 2nd International Conference on Biomedical Engineering and Informatics.2009,3:1343-1347 19.TANG Ya-ling, YANG Yong-zong, WANG Shuang。Mast cell degranulator compound 48-80 promotes atherosclerotic plaque in apolipoprotein E knockout mice with perivascular common carotid collar placement。Chinese Medical Journal(Engl)，2009；122（3）:319-325 20.刘录山，谢闵，姜志胜，杨琼，潘利红，武春艳，唐志晗，唐朝克，危当恒，王佐。pcsk9 siRNA对oxLDL诱导的THP-1源性巨噬细胞凋亡的影响。生物化学与生物物理进展，2009；36（3）：323-330 2008年 21.Dai XY, Ou X, Hao XR, Cao DL, Tang YL, Hu YW, Li XX, Tang CK(通讯作者). The Effect of T0901317 on ATP-Binding Cassette Transporter A1 and Niemann-Pick Type C1 in ApoE-/- Mice. J Cardiovasc Pharmacol. 2008, 51(5):467-475.( IF:2.826) 22.OU Xiang, DAI XiaoYan, LONG ZhiFeng, TANG YaLing, CAO DongLi, HAO XinRui, HU YanWei, LI XiaoXu, TANG ChaoKe(通讯作者). Liver X receptor agonist T0901317 reduces atherosclerotic lesions in apoE-/- mice by upregulating NPC1 expression. Science in China Series C: Life Sciences. 2008, 51(5): 418-429. (IF:0.661) 23.Xiaoyan Dai, Xiang Ou, Xinrui Hao, Dongli Cao, Yaling Tang, Yanwei Hu, Xiaoxu Li, Chaoke Tang (通讯作者) . A Synthetic LXR Agonist T0901317 Inhibits Semicarbazide-Sensitive Amine Oxidase Gene Expression and Activity in ApoE-/- Mice. Acta Biochim Biophys Sin , 2008，40(3): 261-268. (IF:1.086) 24.Yuan ZH, Madamanchi NR, Vendrov AE, Niu XL, Li JX, Runge MS. NADPH oxidase activity does not affect cellular cholesterol loading in vascular smooth muscle cells . Sheng Li Xue Bao,2008, 60(4):511-519. 25.LIN Jie, WANG Lu-ya, LIU Shu, XIA Jun-hui, YONG Qiang, DU Lan-ping, PAN Xiao-dong, XUE Hong, CHEN Bao-sheng and JIANG Zhi-sheng. Functional analysis of low-density lipoprotein receptor in homozygous familial hypercholesterolemia patients with novel 1439 C→T mutation of low-density lipoprotein receptor gene. Chin Med J 2008;121(9):776-781 26.Shuang Wang, Ying Zheng, Yun Yu, Li Xia, Guo-qiang Chen, Yong-zong Yang, Li-shun Wang. Differential proteomics research of camptothecin analog NSC606985 inducing apoptosis in U937 cells: phosphorylation of three kinds of cytoskeleton proteins. Cell Bio int.2008; 32(3):S35-S36 27.Shuang Wang, Ying Zheng, Yun Yu, Li Xia, Guo-qiang Chen, Yong-zong Yang, Li-shun Wang. Phosphorylation of β-actin by protein kinase C-delta in camptothecin analog-induced leukemic cell apoptosis. Acta Pharmacologica Sinica. 2008;29(1):135-142 28.刘录山，程艳丽，谢闵，杨琼，潘利红，姜志胜，唐朝克，危当恒，唐志晗。LDL、oxLDL对THP-1巨噬细胞PCSK9、LDLR表达的影响研究。生物化学与生物物理进展，2008；35（5）：540-547 29.胡炎伟, 唐朝克(通讯作者). 三磷酸腺苷结合盒转运体A1研究的最新进展. 生物化学与生物物理学进展. 2008, 35 (4): 373-379. (IF:0.211) 30.王佐，周晓峰，王仁，童中艺，姜志胜，王贵学。AMD3100对apoE~(-/-)小鼠骨髓源性内皮祖细胞增殖、迁移和黏附的影响 。生物化学与生物物理进展，2008；35(7)：807-813
基因组将为人们找到合适药物 http://news.sciencenet.cn/htmlnews/2011/1/243041.shtm 国际心血管病专家、美国斯克利普斯转化科学研究所所长埃里克·托普尔表示，10年前，测序一个完整的人类基因组可能要30亿美元；2010年其成本降到1万美元左右。2011年，其成本有望降到4000美元。而且，随着测序成本不断降低，基因组研究领域在2011年将会出现更多的医学突破。他说：“这个领域正如雨后春笋一般，蓬勃发展。” Prediction 6: Genomics will find medicines that work for you. Sequencing an entire human genome cost about $3 billion a decade ago. Last year it cost around $10,000, according to Dr. Eric Topol, director of the Scripps Translational Science Institute in La Jolla, Calif. Topol said he expects to see the price drop again in 2011, to about $4,000. And with lower financial barriers, he said, more medical advances from genomic research will come in the next year. http://www.myhealthnewsdaily.com/seven-predicted-medical-advances-in-2011-0949/ Genomics and medicines http://www.gopubmed.org/web/gopubmed/1?WEB018e95z6bgci1oIeI1I00h001000j100200010 信息分析报告 Genomics and medicines 1-19.docx
http://www.gopubmed.org/web/gopubmed/ 1,049 of 1,612,398 documents semantically analyzed Cardiovascular Disease and Type 2 Diabetes Mellitus Risk Factors top author statistics Top Years Publications 2009 672 2008 214 2010 163 2006 1 1 2 3 4 Top Countries Publications USA 273 Italy 66 United Kingdom 65 Germany 39 China 37 Australia 37 Japan 36 France 29 Canada 29 Sweden 28 Netherlands 28 Spain 26 Denmark 20 India 18 Turkey 18 Greece 15 Iran 12 Belgium 12 Taiwan 11 Poland 11 1 2 3 4 1 2 3 ... 21 Top Cities Publications Boston 26 New York 16 London 15 Shanghai 12 Toronto 12 Istanbul 12 Athens 10 Melbourne 10 Utrecht 10 Copenhagen 10 Paris 9 Barcelona 8 Stockholm 8 Lige 8 Amsterdam 7 Tehran 7 San Antonio 7 Baltimore 7 Rome 7 Philadelphia 7 1 2 3 ... 21 1 2 3 ... 24 Top Journals Publications Diabetes Care 40 Diabet Med 28 Metabolism 25 Diabetes Res Clin Pract 21 Diabetologia 19 Am J Cardiol 14 Circulation 13 Vasc Health Risk Manag 11 Cardiovasc Diabetol 11 Diabetes 10 Atherosclerosis 10 Metab Syndr Relat Disord 9 J Hypertens 9 Curr Diab Rep 9 Prim Care Diabetes 9 Am J Clin Nutr 8 Lancet 8 Postgrad Med 8 Bmj 8 Nutr Metab Cardiovasc Dis 8 1 2 3 ... 24 1 2 3 ... 150 Top Terms Publications Risk Factors 1,049 Diabetes Mellitus, Type 2 1,045 Humans 1,001 Cardiovascular Diseases 635 Patients 611 Middle Aged 545 Diabetes Mellitus 439 Aged 424 Adult 364 Hypertension 333 Obesity 331 Metabolism 320 metabolic process 320 Glucose 297 Blood Pressure 283 Prevalence 260 Pressure 254 Insulin 244 receptor binding 233 Syndrome 232 1 2 3 ... 150 1 2 3 ... 269 Top Authors Publications Dekker J 4 Scheen A 4 Haffner S 4 Dahl J 3 Nilsson P 3 Zarich S 3 Hu F 2 Anderson R 2 Taub N 2 Walker B 2 Simmons R 2 Knig W 2 Barnett A 2 ADVANCE Collaborative Group 2 Misra A 2 Steiner G 2 Cannon C 2 Howard B 2 Teede H 2 Sieradzki J 2 1 2 3 ... 269 医学新证据 http://plus.mcmaster.ca/EvidenceUpdates/NewArticles.aspx?Page=1ArticleID=34211#Data He M, van Dam RM, Rimm E, et al. Whole-Grain, Cereal Fiber, Bran, and Germ Intake and the Risks of All-Cause and Cardiovascular Disease-Specific Mortality Among Women With Type 2 Diabetes Mellitus. Circulation. 2010 May 10. (Original) PMID: 20458012 ReadAbstract ReadComments Clinical Evidence Topic: Glycaemiccontrolindiabetes:type2 DISCIPLINE RELEVANCE TO PRACTICE IS THIS NEWS? General Internal Medicine-Primary Care(US) General Practice(GP)/Family Practice(FP) Endocrine Print Save Article Delete Article Email this article to a colleague Abstract BACKGROUND: -Although whole-grain consumption has been associated with a lower risk of cardiovascular diseases (CVD) and mortality in the general population, the association of whole grain with mortality in diabetic patients remains to be determined. This study investigated whole grain and its components cereal fiber, bran, and germ in relation to all-cause and CVD-specific mortality in patients with type 2 diabetes mellitus. Methods and Results-We followed 7822 US women with type 2 diabetes mellitus in the Nurses` Health Study. Dietary intakes and potential confounders were assessed with regularly administered questionnaires. We documented 852 all-cause deaths and 295 CVD deaths during up to 26 years of follow-up. After adjustment for age, the highest versus the lowest fifths of intakes of whole grain, cereal fiber, bran, and germ were associated with 16% to 31% lower all-cause mortality. After further adjustment for lifestyle and dietary risk factors, only the association for bran intake remained significant (P for trend=0.01). The multivariate relative risks across the fifths of bran intake were 1.0 (reference), 0.94 (0.75 to 1.18), 0.80 (0.64 to 1.01), 0.82 (0.65 to 1.04), and 0.72 (0.56 to 0.92). Similarly, bran intake was inversely associated with CVD-specific mortality (P for trend=0.04). The relative risks across the fifths of bran intake were 1.0 (reference), 0.95 (0.66 to 1.38), 0.80 (0.55 to 1.16), 0.76 (0.51 to 1.14), and 0.65 (0.43 to 0.99). Similar results were observed for added bran alone. Conclusions-Whole-grain and bran intakes were associated with reduced all-cause and CVD-specific mortality in women with diabetes mellitus. These findings suggest a potential benefit of whole-grain intake in reducing mortality and cardiovascular risk in diabetic patients. Comments from Clinical Raters General Internal Medicine-Primary Care(US) This story is ongoing, unfortunately most of the chapters are in nutrition, epidemiology and lipidology journals and only a few make their way into main-stream medical journals. It's nice to see this in Circulation. If fiber and bran were sold by a pharmaceutical company they would be hawked at multiple meetings and pushed in multiple journals and rightly so since these are inexpensive, reasonably healthy approaches to a number of medical problems, for eg. type 2 diabetes, obesity, hyperlipidemia and hypertension. Actually high fiber/bran diets are not the most palatable choices and are boring, but they are beneficial. The authors are cautious in their claims and conclusions but their analysis needs to be taken seriously.
标签: 心血管病
