澳大利亚皮肤癌的发生率与死亡率（图解） 诸平 0）皮肤癌的类型 Figure 2: Typical presentation of the four main types of cutaneous melanoma SMM, LM, ALM images generously provided by Dr Alvin Chong, Skin Cancer Foundation Victoria; NM image generously provided by Associate Professor John Kelly, Victorian Melanoma Service, Alfred Health 1）为什么澳大利亚有如此多的皮肤癌患者？ 皮肤癌是澳大利亚最常见的癌症之一，2015年的数据显示，皮肤癌有近100万例。关于皮肤癌的更多信息请浏览系列报道： series about skin : why we have it, what it does, and what can go wrong. Read other articles in the series here . 2）十万人黑色素瘤的发病率 观察和预测每10万人的黑色素瘤发病率，新西兰最高，其次是澳大利亚。 3） 澳大利亚非黑素瘤皮肤癌（NMSC）和黑色素瘤的发病率和死亡率 4）近30余年死亡率变化 5）澳大利亚黑色素瘤的发病率与死亡率 Table 2 Australian incidence and mortality of melanoma Men Women Total Incidence 2012 Count 7,060 4,976 12,036 Age-standardised rate 59.9 39.2 48.7 Mortality 2015 Count 1,004 516 1,520 Age-standardised rate 7.9 3.5 5.5 6）黑色素瘤发病者年龄分布 年龄段/岁 黑色素瘤患者比例/% 40 9.2(9.2% of people diagnosed with melanoma are aged under 40 years) 40-49 11.2 50-59 18.4 60-69 24.4 70-79 20.4 =8 16.3 7)非黑色素瘤的发病率与死亡率 Table 3: Australian incidence and mortality of Non-Melanoma Skin Cancers Men Women Total Incidence 2014 (number of paid Medicare services, not people*) 600,482 358,761 959,243 Incidence per 100,000 2002 (estimated from survey) 1,531 1,036 1,271 Mortality 2013 416 176 592 * Medicare data for numbers of services for NMSC in 2014 are available, otherwise latest incidence data for NMSC is from 2002. NMSC mortality includes deaths from the common skin cancers (SCC BCC) and deaths from the rarer NMSCs like Merkel cell tumours, dermatofibroma protuberans etc. 更多信息请浏览： Contents（ Download as PDF ） 1 Skin cancer in Australia 2 Melanoma incidence and mortality 2.1 Gender 2.2 Age 2.3 Location 2.4 Socio-economic status 2.5 Indigenous status 3 Non-melanoma incidence and mortality 4 Economic impact 5 Survival 6 References Download Cancer Council's skin cancer identification poster to help identify potential skin cancers. 如何保护自己的皮肤
在众多癌症类型中，皮肤癌是最常见的类型之一。美国人一生中患皮肤癌的风险几率高达20%。大多数皮肤癌是由太阳光紫外线直接损伤DNA，引起C→T和CC→TT突变，形成环丁烷嘧啶二聚体所造成。 传统认为，环丁烷嘧啶二聚体中胞嘧啶或5’甲基胞嘧啶迅速脱氨基形成尿嘧啶或胸腺嘧啶是皮肤癌基因突变的机制；而且普遍认为一旦离开太阳光，紫外线的损伤就会停止。 但是，华盛顿大学的学者在《科学》杂志3月份刊出的最新研究结果证明，事实并非如此。即使避开阳光，紫外线通过其他途径，仍然持续损伤皮肤细胞的DNA。这一重大研究结果揭示了黑色素瘤的形成机制。 美捷登：Mike 原文信息 Chemiexcitation of melanin derivativesinduces DNA photoproducts long after UV exposure Science20 February 2015: Vol. 347 no. 6224 pp. 842-847 Mutations in sunlight-induced melanomaarise from cyclobutane pyrimidine dimers (CPDs), DNA photoproducts that aretypically created picoseconds after an ultraviolet (UV) photon is absorbed atthymine or cytosine. We found that in melanocytes, CPDs are generated for 3hours after exposure to UVA, a major component of the radiation in sunlight andin tanning beds. These “dark CPDs” constitute the majority of CPDsand include the cytosine-containing CPDs that initiate UV-signature C→T mutations. Dark CPDs arise when UV-induced reactive oxygen andnitrogen species combine to excite an electron in fragments of the pigmentmelanin. This creates a quantum triplet state that has the energy of a UVphoton but induces CPDs by energy transfer to DNA in a radiation-independentmanner. Melanin may thus be carcinogenic as well as protective against cancer.These findings also validate the long-standing suggestion that chemicallygenerated excited electronic states are relevant to mammalian biology. 原文链接： http://www.sciencemag.org/content/347/6224/842.abstract 美捷登版权www.medjaden.com欢迎转载，转载请勿修改内容 欢迎关注我们的微信
关于硒元素（Selenium，Se）的生物学效应，研究得最多的恐怕是其抗癌作用，但学术界对此历来就存有争议 。 尽管如此，人们还是相信摄硒能够降低癌症风险。许多食物中都富含硒，如巴西坚果（brazil nuts，如下图）。然而，最近的一项随机控制临床试验（ RCCT，randomized controlled clinical trials）研 究表明，硒对非黑素类的皮肤癌、前列腺癌都无防范作用。研究结果发表在 Cochrane Database Syst. Rev （2011年，第5期， DOI: 10.1002/14651858.CD005195 ）上。主持这项研究的是来自德国柏林THR学院（ Institute for Transdisciplinary Health Research ）的 Gabriele Dennert 教授。 该研究组搜索了摄硒效应的临床研究文献，发现了49项预期的观察研究（ observational studies ）和6项随机控制临床试验。其中，观察研究表明，高硒摄入可以防范癌症，但RCCT研究却表明无此明显作用。另外还有迹象表明，如果摄硒时程过长，会造成有害效应。 Russo MW, Murray SC, Wurzelmann JI, Woosley JT, Sandler RS (1997). "Plasma selenium levels and the risk of colorectal adenomas". Nutrition and Cancer 28 (2): 125–9. doi : 10.1080/01635589709514563 . PMID 9290116 . Knekt P, Marniemi J, Teppo L, Helivaara M, Aromaa A (15 November 1998). "Is low selenium status a risk factor for lung cancer?" . American Journal of Epidemiology 148 (10): 975–82. PMID 9829869 . http://aje.oxfordjournals.org/cgi/pmidlookup?view=longpmid=9829869 . Young KJ, Lee PN (1999). "Intervention studies on cancer". European Journal of Cancer Prevention 8 (2): 91–103. doi : 10.1097/00008469-199904000-00003 . PMID 10335455 . Burguera JL, Burguera M, Gallignani M, Alarcón OM, Burguera JA (1990). "Blood serum selenium in the province of Mérida, Venezuela, related to sex, cancer incidence and soil selenium content" (Free full text). Journal of Trace Elements and Electrolytes in Health and Disease 4 (2): 73–7. PMID 2136228 . Clark LC, Combs GF, Turnbull BW, et al. (1996). "Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group". JAMA 276 (24): 1957–63. doi : 10.1001/jama.276.24.1957 . PMID 8971064 . Lippman SM, Klein EA, Goodman PJ, et al. (2009). "Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)" (Free full text). JAMA 301 (1): 39–51. doi : 10.1001/jama.2008.864 . PMID 19066370 . "Chemoprevention Database" . http://www.inra.fr/reseau-nacre/sci-memb/corpet/indexan.html . Retrieved 2009-05-05 . Garland M, Morris JS, Stampfer MJ, et al. (1995). "Prospective study of toenail selenium levels and cancer among women". Journal of the National Cancer Institute 87 (7): 497–505. doi : 10.1093/jnci/87.7.497 . PMID 7707436 . Hercberg S, Galan P, Preziosi P, et al. (1998). "Background and rationale behind the SU.VI.MAX Study, a prevention trial using nutritional doses of a combination of antioxidant vitamins and minerals to reduce cardiovascular diseases and cancers. Supplementation en Vitamines et Minéraux Antioxydants Study" (Free full text). International Journal for Vitamin and Nutrition Research 68 (1): 3–20. PMID 9503043 . http://www.nlm.nih.gov/medlineplus/antioxidants.html . Hercberg S, Galan P, Preziosi P, et al. (2004). "The SU.VI.MAX Study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals" (Free full text). Archives of Internal Medicine 164 (21): 2335–42. doi : 10.1001/archinte.164.21.2335 . PMID 15557412 . "Selenium and Chemotherapy - Nutrition Health" . http://nutrition-health.info/index.php/Selenium_and_Chemotherapeutic_Drugs . "Selenium Cancer" . http://nutrition-health.info/index.php/Selenium_Cancer_1 . Nilsonne G, Sun X, Nystrm C, et al. (2006). "Selenite induces apoptosis in sarcomatoid malignant mesothelioma cells through oxidative stress". Free Radical Biology Medicine 41 (6): 874–85. doi : 10.1016/j.freeradbiomed.2006.04.031 . PMID 16934670 . Tsavachidou D, McDonnell TJ, Wen S, et al. (2009). "Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer" . Journal of the National Cancer Institute 101 (5): 306–20. doi : 10.1093/jnci/djn512 . PMC 2734116 . PMID 19244175 . http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrezartid=2734116 . Klein EA (2009). "Selenium and vitamin E: interesting biology and dashed hope". Journal of the National Cancer Institute 101 (5): 283–5. doi : 10.1093/jnci/djp009 . PMID 19244172 .
http://www.reuters.com/article/healthNews/idUSTRE5984VM20091010 Journal of Investigative Dermatology, September 2009 NEW YORK (Reuters Health) - Want to reduce your risk of skin cancer? Wear sun screen, of course. But two new studies suggest that choosing your relatives carefully could also be helpful. One found that having an identical twin with melanoma increased a person's own risk of developing the disease much more than having a fraternal twin with this type of skin cancer. The other found that having a sibling or parent with one of several different types of non-melanoma skin cancer increased risk as well. Several studies have suggested melanoma and other skin cancers run in families, but it can be difficult to tease out the difference between the influence of genes and environment. In the Australian study, Dr. Sri N. Shekar of the University of Queensland in Brisbane and his colleagues attempted to do so by looking at twin pairs in which at least one sibling had been diagnosed with melanoma. They searched through thousands of cases of melanoma reported in Queensland and New South Wales and found 125 twin pairs. In four of the 27 identical twin pairs, both had melanoma, while three of the 98 fraternal twin pairs had both been diagnosed with the deadly skin cancer. Based on these numbers, having an identical twin with melanoma increased a person's own risk of the disease nearly 10-fold, while melanoma associated with having a non-identical twin with the disease was roughly doubled. This suggests, the researchers say, that some of the increased melanoma risk can be attributed to genes, in particular interactions between genes. They estimate that genes account for about half of the differences in risk between two people. In the second study, Dr. Shehnaz K. Hussain of the University of California Los Angeles and colleagues looked at the Swedish Family-Cancer Database to gauge the risk for several types of skin cancer among siblings and children of people diagnosed with these diseases. They found that people with a sibling or parent diagnosed with some types of skin cancer were more likely to develop skin cancers of various types, not just the ones their relatives had. When tumors occurred at parts of the body more likely to have been exposed to the sun (such as the face, compared to the torso), the familial risk was stronger. Based on the findings, Hussain and colleagues conclude, a person's family history can be used to gauge their own skin cancer risk, and genetic studies could be a useful way to identify potential targets for treating or preventing the disease. http://www.sciencenet.cn/htmlnews/2009/10/224008.shtm 皮肤癌新发现：双胞胎风险激增 亲子难逃遗传 想要降低患皮肤癌的风险？除了涂防晒霜保护皮肤外，研究发现，选择自己的父母和兄弟姐妹也对一个人患皮肤癌几率的高低有影响。 美国《皮肤病学研究杂志》（ JID ）刊登澳大利亚和美国科学家最新研究成果表明，皮肤癌具有遗传性，其发病率与家族基因联系密切。 双胞胎 风险激增 澳大利亚昆士兰大学斯里谢卡尔博士和他的研究小组通过对患有黑色素瘤这种致死性皮肤癌的双胞胎进行研究后发现，同卵双生的双胞胎中如果有一人患有黑色素瘤，那么另一人也患上黑色素瘤的风险将大大增加，甚至高于相同情况的异卵双生双胞胎。 研究小组在昆士兰和新南威尔士两个州调查了数千例黑色素瘤病例，发现其中有125人是双胞胎，包括27例同卵双生和98例异卵双生。 在27例同卵双生双胞胎中，有4对同时患有黑色素瘤；而在98例异卵双生双胞胎中，只有3对同时患有这一疾病。 路透社10月10日援引研究数据报道，如果某人有一个患黑色素瘤的同卵双生兄弟姐妹，那么他本人也患上黑色素瘤的几率约是普通人的10倍；而如果有一个患黑色素瘤的异卵双生兄弟姐妹，那么他本人也患上这种疾病的几率约是普通人的两倍。 亲子间 难逃遗传 由美国加利福尼亚大学洛杉矶分校夏赫纳兹侯赛因博士带领的另一个小组研究了有皮肤癌病史的家族成员患皮肤癌的几率大小。 研究人员通过分析瑞典家庭癌症数据库发现，如果某人的父母或兄弟姐妹患有某种皮肤癌，那么这个人比其他人更有可能患皮肤癌，但不一定是和父母或兄弟姐妹同种类的皮肤癌。 研究人员还发现，当癌细胞出现在容易被太阳照射的部位，如面部时，这种家族遗传性会体现得更明显。 新发现 证实假说 皮肤癌是所有癌症中分布最广泛的种类之一，在任何年龄段都可能发病。 虽然皮肤癌的具体成因至今尚不明确，但可以确定阳光是主要凶手之一。阳光中的紫外线如果长时间照射皮肤，会使皮肤细胞发生变异，引发皮肤癌。 先前有过不少研究指出皮肤癌可能存在某种遗传性关联，但由于它们无法将基因影响和环境影响分开来单独研究，因而始终仅仅是假说而已。 谢卡尔等人的研究第一次用论文的形式证实这种假说的真实性。 研究人员说，他们的研究说明黑色素瘤患病几率的增加可以部分归咎于基因，尤其是基因间的相互影响。他们估计，不同个体之间这种疾病患病风险之所以不同，一半是受基因影响。 更多阅读 美联社相关报道（英文） http://www.gopubmed.org/web/gopubmed/2?WEB017ifjeth1beu6I1aI1I00f01000j10040001rl 1 2 Top Years Publications 2005 12 2007 8 2006 7 2003 7 2008 6 2009 5 2004 5 1998 5 1997 5 1985 5 2002 4 1999 4 1996 4 1995 4 1986 4 2000 3 1989 3 1977 3 1976 3 2001 2 1 2 1 2 Top Countries Publications USA 25 Japan 10 Germany 9 Sweden 7 Italy 7 Spain 3 United Kingdom 3 France 2 Turkey 2 India 2 Australia 2 Israel 2 Iran 1 Pakistan 1 Taiwan 1 United Arab Emirates 1 Poland 1 Brazil 1 Saudi Arabia 1 Netherlands 1 1 2 1 2 3 Top Cities Publications Heidelberg 6 Boston 5 New York 3 Tokyo 3 Barcelona 3 London 3 Rome 2 Bethesda 2 Catania 2 Houston 2 Seattle 2 Kobe 2 Atlanta 1 Uppsala 1 Besanon 1 Tehran 1 Istanbul 1 Charleston 1 Glenview 1 Bangalore 1 1 2 3 1 2 3 4 Top Journals Publications Arch Dermatol 8 J Invest Dermatol 7 J Am Acad Dermatol 7 Int J Cancer 6 Brit J Dermatol 5 Cancer 4 Acta Derm-venereol 4 Pediatr Dermatol 4 J Dermatol 3 Hautarzt 3 Clin Exp Dermatol 3 Am J Dermatopath 3 Ann Dermatol Vener 2 Radiat Res 2 Int J Dermatol 2 Ophthalmology 2 Dermatol Surg 2 Cancer Res 2 Dermatology 2 Cutis 2 1 2 3 4 1 2 3 ... 60 Top Terms Publications Skin Neoplasms 119 Siblings 116 Humans 108 Patients 61 Adult 60 Child 43 Neoplasms 40 Middle Aged 40 Adolescent 36 Carcinoma 34 Diagnosis 27 Parents 27 Syndrome 26 Melanoma 26 Pedigree 24 Incidence 22 Genes 22 autosome 20 Aged 20 Carcinoma, Squamous Cell 20 1 2 3 ... 60 1 2 3 ... 26 Top Authors Publications Hemminki K 4 Geller A 4 Hemminki K 4 Gilchrest B 3 Brooks D 3 Koh H 3 Hussain S 2 Sundquist J 2 Emmons K 2 Powers C 2 Zhang Z 2 Sober A 2 Li F 2 Emmert S 2 Puig S 2 Malvehy J 2 David M 2 Kramer K 2 Khan S 2 Czene K 2 1 2 3 ... 26 http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi Start A-Literature C-Literature B-list Filter Literature A-query: skin cancer and sibling C-query: Pedigree The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 35 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here . The results of this search are saved under id # 14434 and can be accessed from the start page after you leave this session. There are 260 terms on the current B-list ( 113 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin. To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms. Rank Prob B-term 10.99family cancer database 20.99keratin mutation 30.98muir torre syndrome 40.98hogg dube syndrome 50.98xeroderma pigmentosum group 60.98generalized atrophic benign 70.98benign epidermolysis bullosa 80.98atrophic benign epidermolysis 90.98torre syndrome 100.98juvenile hyaline fibromatosis 110.98endocrine neoplasia i 120.98endocrine neoplasia 130.98multiple endocrine neoplasia 140.98mole syndrome 150.98swedish family cancer 160.97infantile myofibromatosis 170.97uveal melanoma 180.97cowden 190.97leiomyomatosis 200.97congenital erythropoietic porphyria 210.97sjogren larsson syndrome 220.97cowden disease 230.96melanoma risk 240.96xeroderma pigmentosum 250.96xeroderma 260.96erythropoietic porphyria 270.96incontinentia pigmenti 280.96polyposis syndrome 290.96cell carcinoma syndrome 300.96familial risk cancer 310.96cutaneous melanoma 320.96dystrophic epidermolysis bullosa 330.96retinoblastoma patient 340.95nevus 350.95epidermodysplasia verruciformis 360.95recessive dystrophic epidermolysis 370.95piebaldism 380.95epidermolysis bullosa simplex 390.95rothmund thomson syndrome 400.95rothmund 410.94cancer genetic 420.94familial malignant melanoma 430.94cardiac myxoma 440.94basal cell carcinoma 450.94hermansky pudlak syndrome 460.92family cancer 470.92multiple primary melanoma 480.91familial syringoma 490.91risk cancer 500.91uveal melanoma a 510.91male pseudohermaphroditism 520.90carcinoma syndrome 530.90familial kaposi sarcoma 540.90myeloid malignancy 550.90epidermolysis bullosa 560.89gorlin syndrome 570.89pseudohermaphroditism 580.89naevi 590.89myxoma 600.89counseling cancer 610.89bloom syndrome 620.88epidermolysis 630.88porphyria 640.87spiradenoma 650.87atrichia 660.86spinocerebellar degeneration 670.86paget disease 680.85gorlin 690.84fibromatosis 700.84hyperpigmentation 710.84eccrine spiradenoma 720.83melanoma risk factor 730.83spinocerebellar 740.82melanocytic 750.80paget 760.80myxoma a 770.79familial malignant 780.78primary melanoma 790.74monooxygenase activity 800.74subungual 810.73retinoblastoma 820.73mole 830.73xeroderma pigmentosum complementation 840.71syndrome cardiac myxoma 850.71polyposis 860.71c ha 870.70pituitary adenoma 880.70parental cancer 890.68xeroderma pigmentosum patient 900.66hereditary spinocerebellar degeneration 910.66skin cancer 920.65cushing syndrome 930.65familial clustering cancer 940.64dermoid 950.64t cell lymphoma 960.63leukemia lymphoma 970.63family history 980.60cushing 990.60meningioma 1000.59medulloblastoma 1010.58genetic disease 1020.58polyp 1030.57renal cell carcinoma 1040.56perifollicular fibroma 1050.56carcinoma a 1060.54melanoma a 1070.54host disease 1080.52non hodgkin lymphoma 1090.51ovarian cancer 1100.49lung cancer patient 1110.49tumor a nation 1120.48melanoma patient 1130.47polyp colon 1140.47genetic predisposition 1150.47keratoacanthomas 1160.46malignant melanoma a 1170.45pancreatic cancer 1180.44multiple eccrine spiradenoma 1190.44cell cancer 1200.43melanoma atypical 1210.42ewing sarcoma 1220.42acute lymphoblastic leukaemia 1230.41case xeroderma 1240.40carcinoma tongue 1250.40melanoma 1260.37unrelated 1270.36incomplete male pseudohermaphroditism 1280.34primary malignancy 1290.32mycosis fungoide 1300.32syndrome two 1310.31sjogren 1320.31myelocytic leukemia 1330.30family tumor 1340.30patient piebaldism 1350.30case xeroderma pigmentosum 1360.30ewing 1370.29tinea 1380.29anemia 1390.28syndrome three 1400.28sarcoma a 1410.27cancer a 1420.25skin tumor 1430.25atrophic 1440.23familial tumor 1450.23malignant melanoma 1460.22mutation 1470.22breast cancer 1480.21mutation caucasian 1490.21childhood adolescent cancer 1500.20childhood cancer 1510.20fibroma 1520.19hodgkin lymphoma 1530.19specific breast cancer 1540.19neoplasia 1550.19dysplasia 1560.19familial association 1570.19cancer site 1580.17malignant conversion 1590.17lung cancer 1600.17cancer control 1610.16patient melanoma 1620.16atopic 1630.15hemangiopericytoma 1640.14adrenocortical 1650.14kaposi sarcoma 1660.14degeneration 1670.14normal keratinocyte 1680.14inbred strain 1690.13papillomatosis 1700.12sclerosis 1710.12hematologic cancer 1720.12history 1730.11hodgkin 1740.10male pseudohermaphroditism associated 1750.10fibrosis 1760.09skin lesion 1770.09ha 1780.09pseudohermaphroditism associated 1790.08cancer 1800.08cell carcinoma 1810.08cell lymphoma 1820.08endocrine 1830.08cancer patient 1840.07squamous cell carcinoma 1850.06brain tumor 1860.06sarcoma family 1870.06cancer nuclear 1880.06cystic fibrosis 1890.06cancer development 1900.06hemangiomatosis 1910.06meningoencephalitis 1920.06cancer cancer 1930.05acd 1940.05syndrome cardiac 1950.05malignancy a 1960.05perifollicular 1970.05tumorigenesis 1980.05lymphoma family 1990.04acute myelocytic leukemia 2000.04squamous 2010.04pathological finding 2020.04syndrome a 2030.03ionizing radiation 2040.03adenoma associated 2050.03papilloma 2060.03adenoma 2070.03mucocutaneous 2080.02tumor a 2090.02solid tumor 2100.02abnormality 2110.02finding 2120.02leukaemia 2130.02histopathologic 2140.02systemic sclerosis 2150.02carcinogenesis 2160.02patient cystic fibrosis 2170.01lesion a 2180.01enlargement 2190.01loss 2200.01lymphoma 2210.01malignancy 2220.01sarcoma 2230.00breast cancer cancer 2240.00hormone imbalance 2250.00increased sensitivity 2260.00carcinoma 2270.00syndrome 2280.00leukemia 2290.00neoplasm 2300.00excess 2310.00central nervous 2320.00disease 2330.00red 2340.00colonic carcinoma 2350.00malignant 2360.00nervous 2370.00murray 2380.00clinical observation 2390.00death 2400.00depressed 2410.00amino 2420.00associated tumor 2430.00strain 2440.00lymphoma associated 2450.00retention 2460.00exposure 2470.00normal skin 2480.00tumor 2490.00sensitivity 2500.00tumor onset 2510.00tumor development 2520.00lesion 2530.00critical 2540.00therapy 2550.00observation 2560.00normal 2570.00morphologic 2580.00therapeutic response 2590.00disease late 2600.00activity Restrict by semantic categories? Start A-Literature C-Literature B-list Filter Literature AB literature B-term BC literature skin cancer and sibling muir torre syndrome Pedigree 1: An individual with Muir-Torre syndrome found to have a pathogenic MSH6 gene mutation.2007 Add to clipboard 2: Muir-Torre syndrome : a case of two brothers.2006 Add to clipboard 1: Identifying Muir-Torre syndrome in a patient with glioblastoma multiforme.2009 Add to clipboard 2: A new mutation in Muir-Torre syndrome associated with familiar transmission of different gastrointestinal adenocarcinomas.2009 Add to clipboard 3: Muir-Torre syndrome caused by partial duplication of MSH2 gene by Alu-mediated nonhomologous recombination.2008 Add to clipboard 4: Muir-Torre Syndrome : expanding the genotype and phenotype--a further family with a MSH6 mutation.2008 Add to clipboard 5: Genes are more than skin deep: a case of Muir-Torre syndrome .2008 Add to clipboard 6: More than just skin deep!: a report on a family with Muir-Torre syndrome .2007 Add to clipboard 7: Identification of Muir-Torre syndrome among patients with sebaceous tumors and keratoacanthomas: role of clinical features, microsatellite instability, and immunohistochemistry.2005 Add to clipboard 8: Different phenotypes in Muir-Torre syndrome : clinical and biomolecular characterization in two Italian families.2005 Add to clipboard 9: Attenuated familial adenomatous polyposis and Muir-Torre syndrome linked to compound biallelic constitutional MYH gene mutations.2005 Add to clipboard 10: Muir-Torre syndrome : role of the dermatopathologist in diagnosis.2004 Add to clipboard 11: Molecular pathologic analysis enhances the diagnosis and management of Muir-Torre syndrome and gives insight into its underlying molecular pathogenesis.2001 Add to clipboard 12: 2001 Add to clipboard 13: Probable involvement of a germ-line mutation of an unknown mismatch repair gene in a Japanese Muir-Torre syndrome phenotype.2000 Add to clipboard 14: New mutation in the hMSH2 gene in a Spanish Muir-Torre syndrome .2000 Add to clipboard 15: Colorectal cancer and the Muir-Torre syndrome in a Gypsy family: a review.1999 Add to clipboard 16: 1999 Add to clipboard 17: 1999 Add to clipboard 18: A Muir-Torre syndrome family.1998 Add to clipboard 19: Widespread microsatellite instability in sebaceous tumours of patients with the Muir-Torre syndrome .1997 Add to clipboard 20: The genetic basis of Muir-Torre syndrome includes the hMLH1 locus.1996 Add to clipboard 21: Is the mismatch repair deficient type of Muir-Torre syndrome confined to mutations in the hMSH2 gene?1996 Add to clipboard 22: Clinicopathological relevance of the association between gastrointestinal and sebaceous neoplasms: the Muir-Torre syndrome .1995 Add to clipboard 23: Muir-Torre syndrome : a variant of the cancer family syndrome.1994 Add to clipboard 24: Genetic linkage in Muir-Torre syndrome to the same chromosomal region as cancer family syndrome.1994 Add to clipboard 25: The familial Muir-Torre syndrome .1993 Add to clipboard 26: Muir-Torre syndrome associated with a family history of hyperlipidemia.1993 Add to clipboard 27: Muir-Torre syndrome .1992 Add to clipboard 28: Muir-Torre syndrome : a case report.1991 Add to clipboard 29: 1991 Add to clipboard 30: Mucous cell hyperplasia in an odontogenic cyst from a patient with Muir-Torre syndrome .1990 Add to clipboard 31: Muir-Torre syndrome .1986 Add to clipboard 32: Muir-Torre syndrome in several members of a family with a variant of the Cancer Family Syndrome.1985 Add to clipboard job id # 14434 started Mon Oct 12 03:06:21 2009 Max_citations: 50000 Stoplist: /var/www/html/arrowsmith_uic/data/stopwords_pubmed Ngram_max: 3 14434 Search ARROWSMITH A A_query_raw: skin cancer and sibling Mon Oct 12 03:07:22 2009 A query = skin cancer and sibling started Mon Oct 12 03:07:23 2009 A query resulted in 187 titles 14434 Search ARROWSMITH C C_query_raw: Pedigree Mon Oct 12 03:07:33 2009 C: Pedigree 64398 A: pubmed_query_A 187 AC: ( skin cancer and sibling ) AND ( Pedigree ) 35 C query = Pedigree started Mon Oct 12 03:07:34 2009 C query resulted in 50000 titles A AND C query resulted in 35 titles 1102 B-terms ready on Mon Oct 12 03:11:20 2009 Sem_filter: Disorders 260 B-terms left after filter executed Mon Oct 12 03:13:59 2009 Viewed B-terms Mon Oct 12 03:15:11 2009 muir torre syndrome B-list on Mon Oct 12 03:15:53 2009 1 family cancer database 2 keratin mutation 3 muir torre syndrome 4 hogg dube syndrome 5 xeroderma pigmentosum group 6 generalized atrophic benign 7 benign epidermolysis bullosa 8 atrophic benign epidermolysis 9 torre syndrome 10 juvenile hyaline fibromatosis 11 endocrine neoplasia i 12 endocrine neoplasia 13 multiple endocrine neoplasia 14 mole syndrome 15 swedish family cancer 16 infantile myofibromatosis 17 uveal melanoma 18 cowden 19 leiomyomatosis 20 congenital erythropoietic porphyria 21 sjogren larsson syndrome 22 cowden disease 23 melanoma risk 24 xeroderma pigmentosum 25 xeroderma 26 erythropoietic porphyria 27 incontinentia pigmenti 28 polyposis syndrome 29 cell carcinoma syndrome 30 familial risk cancer 31 cutaneous melanoma 32 dystrophic epidermolysis bullosa 33 retinoblastoma patient 34 nevus 35 epidermodysplasia verruciformis 36 recessive dystrophic epidermolysis 37 piebaldism 38 epidermolysis bullosa simplex 39 rothmund thomson syndrome 40 rothmund 41 cancer genetic 42 familial malignant melanoma 43 cardiac myxoma 44 basal cell carcinoma 45 hermansky pudlak syndrome 46 family cancer 47 multiple primary melanoma 48 familial syringoma 49 risk cancer 50 uveal melanoma a 51 male pseudohermaphroditism 52 carcinoma syndrome 53 familial kaposi sarcoma 54 myeloid malignancy 55 epidermolysis bullosa 56 gorlin syndrome 57 pseudohermaphroditism 58 naevi 59 myxoma 60 counseling cancer 61 bloom syndrome 62 epidermolysis 63 porphyria 64 spiradenoma 65 atrichia 66 spinocerebellar degeneration 67 paget disease 68 gorlin 69 fibromatosis 70 hyperpigmentation 71 eccrine spiradenoma 72 melanoma risk factor 73 spinocerebellar 74 melanocytic 75 paget 76 myxoma a 77 familial malignant 78 primary melanoma 79 monooxygenase activity 80 subungual 81 retinoblastoma 82 mole 83 xeroderma pigmentosum complementation 84 syndrome cardiac myxoma 85 polyposis 86 c ha 87 pituitary adenoma 88 parental cancer 89 xeroderma pigmentosum patient 90 hereditary spinocerebellar degeneration 91 skin cancer 92 cushing syndrome 93 familial clustering cancer 94 dermoid 95 t cell lymphoma 96 leukemia lymphoma 97 family history 98 cushing 99 meningioma 100 medulloblastoma 101 genetic disease 102 polyp 103 renal cell carcinoma 104 perifollicular fibroma 105 carcinoma a 106 melanoma a 107 host disease 108 non hodgkin lymphoma 109 ovarian cancer 110 lung cancer patient 111 tumor a nation 112 melanoma patient 113 polyp colon 114 genetic predisposition 115 keratoacanthomas 116 malignant melanoma a 117 pancreatic cancer 118 multiple eccrine spiradenoma 119 cell cancer 120 melanoma atypical 121 ewing sarcoma 122 acute lymphoblastic leukaemia 123 case xeroderma 124 carcinoma tongue 125 melanoma 126 unrelated 127 incomplete male pseudohermaphroditism 128 primary malignancy 129 mycosis fungoide 130 syndrome two 131 sjogren 132 myelocytic leukemia 133 family tumor 134 patient piebaldism 135 case xeroderma pigmentosum 136 ewing 137 tinea 138 anemia 139 syndrome three 140 sarcoma a 141 cancer a 142 skin tumor 143 atrophic 144 familial tumor 145 malignant melanoma 146 mutation 147 breast cancer 148 mutation caucasian 149 childhood adolescent cancer 150 childhood cancer 151 fibroma 152 hodgkin lymphoma 153 specific breast cancer 154 neoplasia 155 dysplasia 156 familial association 157 cancer site 158 malignant conversion 159 lung cancer 160 cancer control 161 patient melanoma 162 atopic 163 hemangiopericytoma 164 adrenocortical 165 kaposi sarcoma 166 degeneration 167 normal keratinocyte 168 inbred strain 169 papillomatosis 170 sclerosis 171 hematologic cancer 172 history 173 hodgkin 174 male pseudohermaphroditism associated 175 fibrosis 176 skin lesion 177 ha 178 pseudohermaphroditism associated 179 cancer 180 cell carcinoma 181 cell lymphoma 182 endocrine 183 cancer patient 184 squamous cell carcinoma 185 brain tumor 186 sarcoma family 187 cancer nuclear 188 cystic fibrosis 189 cancer development 190 hemangiomatosis 191 meningoencephalitis 192 cancer cancer 193 acd 194 syndrome cardiac 195 malignancy a 196 perifollicular 197 tumorigenesis 198 lymphoma family 199 acute myelocytic leukemia 200 squamous 201 pathological finding 202 syndrome a 203 ionizing radiation 204 adenoma associated 205 papilloma 206 adenoma 207 mucocutaneous 208 tumor a 209 solid tumor 210 abnormality 211 finding 212 leukaemia 213 histopathologic 214 systemic sclerosis 215 carcinogenesis 216 patient cystic fibrosis 217 lesion a 218 enlargement 219 loss 220 lymphoma 221 malignancy 222 sarcoma 223 breast cancer cancer 224 hormone imbalance 225 increased sensitivity 226 carcinoma 227 syndrome 228 leukemia 229 neoplasm 230 excess 231 central nervous 232 disease 233 red 234 colonic carcinoma 235 malignant 236 nervous 237 murray 238 clinical observation 239 death 240 depressed 241 amino 242 associated tumor 243 strain 244 lymphoma associated 245 retention 246 exposure 247 normal skin 248 tumor 249 sensitivity 250 tumor onset 251 tumor development 252 lesion 253 critical 254 therapy 255 observation 256 normal 257 morphologic 258 therapeutic response 259 disease late 260 activity
标签: 皮肤癌
