解决Error 1325. EsriPyFldr is not a valid short file name. I was also getting the error 1325 when trying to uninstall ArcGIS Desktop 10.3.1. The fix was to remove a couple of CD/DVD (virtual) drives from the system. 去尝试各种卸载办法(甚至求助esri)之前,也许应该看看是不是电脑盘符的变化让esri感觉你盗版了,呵呵。