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Rosalind - IPRB - Heridity
lucky7 2019-9-18 09:24
解此题的关键在于这是一个没有放回的抽取,不然例子里50%的显性基因应该无脑得出0.75的显性特征而不是匪夷所思的0.78333 显性特征的情况太多,采取显性 = 1-隐性特征,并按题目中的树形图思路列出可能: 先抽aa再抽aa, 100%得aa: n_n_aa=n/(k+m+n)*(n-1)/(k+m+n-1) 先抽Aa再抽aa, 50%得aa: m_n_aa=m/(k+m+n)*0.5*n/(k+m-1+n) 先抽aa再抽Aa, 50%得aa: n_m_aa=n/(k+m+n)*m/(k+m+n-1)*0.5 先抽Aa再抽Aa, 25%得aa: m_m_aa=m/(k+m+n)*0.5*(m-1)/(k+m+n-1)*0.5 最后一减 1-(n_n_aa+m_n_aa+n_m_aa+m_m_aa) 以上代码是可行的,但是有些重复计算: k + m + n = N 先抽Aa再抽aa和先抽aa再抽Aa概率一致可以不用算两遍 其实最后就是合并一下同类项: 1-1/(N-1)/N*(n*(n-1)+m*n+m*(m-1)*0.25) 好吧这一题跟编程无任何关系...
个人分类: Rosalind|1888 次阅读|0 个评论
Heredity - Table of Contents alert Volume 104 Issue 6
xupeiyang 2010-5-19 20:37
HEREDITY June 2010 Volume 104 Number 6, pp 519 - 610 --------------------------------------------------------------------- Research Diversity Limited-time web focus The Journal of Human Genetics is proud to present Research Diversity - a limited-time web focus featuring the following topics: - Susceptibility genes to complex diseases - Towards personalized medicine - Ancient DNA and population diversity. Take advantage of free content through Research Diversity today! http://links.ealert.nature.com/ctt?kn=24m=34898460r=Mzg0ODUxNzc0MAS2b=2j=NzQxMzQ4MTIS1mt=1rt=0 ---------------------- NEWS AND COMMENTARY ---------------------- What's your poison W Wuster http://links.ealert.nature.com/ctt?
个人分类: 信息资源|1326 次阅读|0 个评论
Heredity - Table of Contents alert Volume 104 Issue 2
xupeiyang 2010-1-21 08:08
TABLE OF CONTENTS Volume 104, Issue 2 (February 2010) In this issue Editorial News and Commentaries Original Articles Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe A new generation of educational tools for a new generation of students Connect with your students through Scitable 's digital library and visually based courses. Create a virtual classroom today. Advance Online Publication Articles for this journal are published online ahead of print through Advance Online Publication (AOP), meaning that the latest research reaches you in the timeliest way possible. Check the AOP webpage each week to make sure that you are not left behind. Editorial Top Gems from the Heredity Archive RogerButlin Managing Editor Heredity 2010 104: 121; 10.1038/hdy.2009.177 Abstract | Full Text News and Commentaries Top Scrapie genetics before the discovery of prions JSlate Heredity 2010 104: 122-123; advance online publication, August 26, 2009; 10.1038/hdy.2009.113 Abstract | Full Text Inbreeding in the wild really does matter RFrankham Heredity 2010 104: 124; advance online publication, November 18, 2009; 10.1038/hdy.2009.155 Abstract | Full Text Original Articles Top Proteomic characterization of a temperature-sensitive conditional lethal in Drosophila melanogaster K SPedersen, M CCodrea, C JVermeulen, VLoeschcke and EBendixen Heredity 2010 104: 125-134; advance online publication, October 7, 2009; 10.1038/hdy.2009.132 Abstract | Full Text Apparent high recombination rates in clonal parasitic organisms due to inappropriate sampling design FPrugnolle and TDe Meeus Heredity 2010 104: 135-140; advance online publication, October 7, 2009; 10.1038/hdy.2009.128 Abstract | Full Text Sperm competition and offspring viability at hybridization in Australian tree frogs, Litoria peronii and L. tyleri C D HSherman, EWapstra and MOlsson Heredity 2010 104: 141-147; advance online publication, September 2, 2009; 10.1038/hdy.2009.118 Abstract | Full Text The role of human demographic history in determining the distribution and frequency of transferase-deficient galactosaemia mutations J MFlanagan, GMcMahon, S HBrendan Chia, PFitzpatrick, OTighe, CO'Neill, PBriones, LGort, LKozak, AMagee, ENaughten, BRadomyska, MSchwartz, J SShin, W MStrobl, L ATyfield, H RWaterham, HRussell, GBertorelle, J K VReichardt, P DMayne and D TCroke Heredity 2010 104: 148-154; advance online publication, July 29, 2009; 10.1038/hdy.2009.84 Abstract | Full Text Selection at the MHC class IIB locus across guppy ( Poecilia reticulata ) populations B AFraser, I WRamnarine and B DNeff Heredity 2010 104: 155-167; advance online publication, July 29, 2009; 10.1038/hdy.2009.99 Abstract | Full Text Fine-scale genetic structure and dispersal distance in the harvester ant Pogonomyrmex barbatus S SSuni and D MGordon Heredity 2010 104: 168-173; advance online publication, September 30, 2009; 10.1038/hdy.2009.124 Abstract | Full Text Distribution of Wolbachia infection in Chorthippus parallelus populations within and beyond a Pyrenean hybrid zone MZabal-Aguirre, FArroyo and J LBella Heredity 2010 104: 174-184; advance online publication, September 9, 2009; 10.1038/hdy.2009.106 Abstract | Full Text Molecular evidence for the natural production of homozygous Cupressus sempervirens L. lines by Cupressus dupreziana seed trees J L RNava, ABuonamici, G GVendramin and CPichot Heredity 2010 104: 185-190; advance online publication, August 26, 2009; 10.1038/hdy.2009.112 Abstract | Full Text A sex-determining region on the Y chromosome controls the sex-reversal ratio in interspecific hybrids between Oryzias curvinotus females and Oryzias latipes males MKato, YTakehana, MSakaizumi and SHamaguchi Heredity 2010 104: 191-195; advance online publication, September 16, 2009; 10.1038/hdy.2009.114 Abstract | Full Text Horn type and horn length genes map to the same chromosomal region in Soay sheep S EJohnston, DBeraldi, A FMcRae, J MPemberton and JSlate Heredity 2010 104: 196-205; advance online publication, August 19, 2009; 10.1038/hdy.2009.109 Abstract | Full Text The genetic basis of recessive self-colour pattern in a wild sheep population JGratten, J GPilkington, E ABrown, DBeraldi, J MPemberton and JSlate Heredity 2010 104: 206-214; advance online publication, August 12, 2009; 10.1038/hdy.2009.105 Abstract | Full Text Meiotic aberrations during 2n pollen formation in Begonia ADewitte, TEeckhaut, JVan Huylenbroeck and EVan Bockstaele Heredity 2010 104: 215-223; advance online publication, August 26, 2009; 10.1038/hdy.2009.111 Abstract | Full Text Transcriptional differences between triploid and diploid Chinook salmon ( Oncorhynchus tshawytscha ) during live Vibrio anguillarum challenge BChing, SJamieson, J WHeath, D DHeath and AHubberstey Heredity 2010 104: 224-234; advance online publication, August 26, 2009; 10.1038/hdy.2009.108 Abstract | Full Text
个人分类: 科学研究|1504 次阅读|0 个评论
Heredity - Table of Contents alert Volume 104 Issue 1 (January 2010) 2009年12月1
热度 1 xupeiyang 2009-12-16 22:26
TABLE OF CONTENTS Volume 104, Issue 1 (January 2010) In this issue News and Commentary Original Articles Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Science education has just evolved Nature Education's Scitable offers peer-reviewed readings, video-based simulations, and much more. Scitable is a powerful free tool to immerse your students in genetics. Build a Scitable classroom today. Advance Online Publication Articles for this journal are published online ahead of print through Advance Online Publication (AOP), meaning that the latest research reaches you in the timeliest way possible. Check the AOP webpage each week to make sure that you are not left behind. News and Commentary Top New insights into plant graft hybridization Y-SLiu, Q-LWang and B-YLi Heredity 2010 104: 1-2; advance online publication, August 26, 2009; 10.1038/hdy.2009.115 Abstract | Full Text Original Articles Top New insights on the speciation history and nucleotide diversity of three boreal spruce species and a Tertiary relict JChen, TKllman, NGyllenstrand and MLascoux Heredity 2010 104: 3-14; advance online publication, July 29, 2009; 10.1038/hdy.2009.88 Abstract | Full Text Rapid evolution of Wolbachia density in insecticide resistant Culex pipiens PEchaubard, ODuron, PAgnew, CSidobre, VNol, MWeill and YMichalakis Heredity 2010 104: 15-19; advance online publication, August 5, 2009; 10.1038/hdy.2009.100 Abstract | Full Text Quantitative genetic architecture of parasite-induced cataract in rainbow trout, Oncorhynchus mykiss HKuukka-Anttila, NPeuhkuri, IKolari, TPaananen and AKause Heredity 2010 104: 20-27; advance online publication, September 23, 2009; 10.1038/hdy.2009.123 Abstract | Full Text Genetic diversity in a crop metapopulation Jvan Heerwaarden, F Avan Eeuwijk and JRoss-Ibarra Heredity 2010 104: 28-39; advance online publication, September 9, 2009; 10.1038/hdy.2009.110 Abstract | Full Text Temporally stable genetic structure of heavily exploited Atlantic herring ( Clupea harengus ) in Swedish waters L CLarsson, LLaikre, CAndr, T GDahlgren and NRyman Heredity 2010 104: 40-51; advance online publication, August 5, 2009; 10.1038/hdy.2009.98 Abstract | Full Text Genetic variation of inbreeding depression among floral and fitness traits in Silene nutans JThiele, THansen, H RSiegismund and T PHauser Heredity 2010 104: 52-60; advance online publication, August 19, 2009; 10.1038/hdy.2009.103 Abstract | Full Text Response to selection and realized heritability of sperm length in the yellow dung fly ( Scathophaga stercoraria ) RDobler and D JHosken Heredity 2010 104: 61-66; advance online publication, July 29, 2009; 10.1038/hdy.2009.93 Abstract | Full Text Avian genome evolution: insights from a linkage map of the blue tit ( Cyanistes caeruleus ) BHansson, MLjungqvist, D ADawson, J CMueller, JOlano-Marin, HEllegren and J-Nilsson Heredity 2010 104: 67-78; advance online publication, August 26, 2009; 10.1038/hdy.2009.107 Abstract | Full Text Quantifying male-biased dispersal among social groups in the collared peccary ( Pecari tajacu) using analyses based on mtDNA variation J DCooper, RVitalis, P MWaser, DGopurenko, E CHellgren, T MGabor and J ADeWoody Heredity 2010 104: 79-87; advance online publication, July 29, 2009; 10.1038/hdy.2009.102 Abstract | Full Text Inferring introduction routes of invasive species using approximate Bayesian computation on microsatellite data TGuillemaud, M ABeaumont, MCiosi, J-MCornuet and AEstoup Heredity 2010 104: 88-99; advance online publication, August 5, 2009; 10.1038/hdy.2009.92 Abstract | Full Text Segregation distortion and the evolution of sex-determining mechanisms MKozielska, F JWeissing, L WBeukeboom and IPen Heredity 2010 104: 100-112; advance online publication, August 12, 2009; 10.1038/hdy.2009.104 Abstract | Full Text Frequent silencing of rDNA loci on the univalent-forming genomes contrasts with their stable expre ssion on the bivalent-forming genomes in polyploid dogroses ( Rosa sect. Caninae ) LKhaitov, GWerlemark, HNybom and AKova ? k Heredity 2010 104: 113-120; advance online publication, July 29, 2009; 10.1038/hdy.2009.94 Abstract | Full Text Advertisement Looking to publish your next paper? Submit to the Journal of Human Genetics today. The Journal of Human Genetics (JHG) is a great outlet in which to publish your next paper in a timely manner. JHG covers all aspects of human genetics with a focus on medical genetics and genomics. This journal accepts papers related to: - medical genetics - human genome analysis - gene cloning and mapping - mutational analysis - gene therapy - cancer genetics. Review the Guide to Authors and Submit today .
个人分类: 遗传病学|2649 次阅读|1 个评论

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