详细信息见 http://f1000medicine.com/browse/CRITCARE 国际医学专家按F1000 Factor评出的危重医疗与急症医学研究国际优秀论文，你可以选择查阅近一周至近五年发表的优秀论文。 可按以下分类进行检索查阅： Critical Care Emergency Medicine Acute Cardiovascular Problems Emergency Medicine Ethics Organization in Critical Care Emergency Medicine Metabolic Disorders in Critical Care Neurological Problems in Critical Care Pediatric Problems in Critical Care Renal Gastrointestinal Problems in Critical Care Respiratory Problems in Critical Care Sepsis Multiple Organ Failure in Critical Care
请见 http://f1000medicine.com/top10/classics/ 1 Exceptional F1000 Factor 12.6 Changes Clinical Practice Confirmation Hypothesis New Finding Controversial Refutation Intensive versus conventional glucose control in critically ill patients. Finfer S, Chittock DR, , Robinson BG, Ronco JJ N Engl J Med 2009 Mar 26 360 :1283-97 Selected by | BenediktPreckel / WalterHasibeder / Jean-CharlesPreiser / NicholasBarrett / NigelWebster / Emine Aysu Salviz and AlainVuylsteke / Jacobo Sellares and AntoniTorres / GregMartin / Patrice Forget and MarcDe Kock / JohnLaffey / Jose Pascual and BabakSarani / Priya Shah and SethField / BruceBistrian / Ashish Sinha and JohnAugoustides / Regina Schumann and ManfredSeeberger First evaluation 31Mar2009 | Latest evaluation 11Aug2009 2 Exceptional F1000 Factor 12.4 Confirmation New Finding Dabigatran versus warfarin in patients with atrial fibrillation. Connolly SJ, Ezekowitz MD, , Wallentin L, RE-LY Steering Committee and Investigators N Engl J Med 2009 Sep 17 361 (12):1139-51 Selected by | RobertRuff / Rakesh Gopinathannair and BrianOlshansky / Jos A Garca Donaire and LuisRuilope / WilbertAronow / Sung Ham and FredWeaver / Fernando Testai and PhilipGorelick / Guy Amit and I EliOvsyshcher / Anna Maria Choy and ChimLang / HeatherBloom / HarriJenkins / WolfgangSchoels / AshfaqShuaib / Aleksandra Pikula and CarlosKase / Angela Adams, Jeffrey Veluz and MeganLeary First evaluation 7Sep2009 | Latest evaluation 18Jan2010 3 Exceptional F1000 Factor 11.5 Changes Clinical Practice Confirmation Hypothesis New Finding Controversial Refutation Anesthesia awareness and the bispectral index. Avidan MS, Zhang L, , Jacobsohn E, Evers AS N Engl J Med 2008 Mar 13 358 (11):1097-108 Selected by | VesnaJevtovic-Todorovic / PhilippaNewfield / BeverleyOrser / EmeryBrown / HaraldGroeben / BenediktPannen / ManfredSeeberger / AlainBorgeat / LyndaWells / DhaneshGupta / Serene Leo and AlexSia / PaulBarash / MichaelO'Connor / MasahikoKawaguchi Dissenters | Elise Sarton and AlbertDahan / Seppo Alahuhta and VilleJantti Author Response | Avidan MS, Zhang L, Burnside BA, Finkel KJ, Searleman AC, Selvidge JA, Saager L, Turner MS, Rao S, Bottros M, Hantler C, Jacobsohn E, Evers AS. B-Unaware Trial Group / Avidan et al. / Avidan et al. / Avidan et al. / Avidan et al. / Avidan et al. / Avidan et al. / Avidan et al. / Avidan et al. / Avidan et al. / Avidan et al. / Avidan et al. / Avidan et al. / Avidan et al. First evaluation 18Mar2008 | Latest evaluation 11Jun2008 4 Exceptional F1000 Factor 11.2 Confirmation Hypothesis New Finding Tech Advance Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers. Binshtok AM, Bean BP, Woolf CJ Nature 2007 Oct 4 449 (7162):607-10 Selected by | MishaPerouansky / NannaFinnerup / HughHemmings / EmeryBrown / HelgeEilers / DavidArcher / Daniel Vilceanu and CherylStucky / MichaelSchaefer First evaluation 23Oct2007 | Latest evaluation 13Mar2008 5 Exceptional F1000 Factor 10.7 Changes Clinical Practice Confirmation New Finding Treatment of hypertension in patients 80 years of age or older. Beckett NS, Peters R, , Bulpitt CJ, HYVET Study Group N Engl J Med 2008 May 1 358 (18):1887-98 Selected by | Dharam Kumbhani and DeepakBhatt / Ramachandran S.Vasan / JeromeFleg / AnnemarieHennessy / ErnestoSchiffrin / WilbertAronow / Joji Ishikawa and KazuomiKario First evaluation 14Apr2008 | Latest evaluation 3Jun2008 6 Exceptional F1000 Factor 10.5 Changes Clinical Practice Confirmation Hypothesis New Finding Controversial Refutation Intensity of renal support in critically ill patients with acute kidney injury. VA/NIH Acute Renal Failure Trial Network, Palevsky PM, , Star RA, Peduzzi P N Engl J Med 2008 Jul 3 359 (1):7-20 Selected by | AchimJoerres / AndrewDavenport / JohnLaffey / GregMartin / Arrigo Schieppati and GiuseppeRemuzzi / HeleenOudemans-van Straaten / WilliamMitch First evaluation 2Jun2008 | Latest evaluation 14Aug2008 7 Exceptional F1000 Factor 10.4 Changes Clinical Practice Confirmation New Finding Controversial Effects of intensive blood-pressure control in type 2 diabetes mellitus. ACCORD Study Group, Cushman WC, , Gerstein HC, Ismail-Beigi F N Engl J Med 2010 Apr 29 362 (17):1575-85 Selected by | David Barit and MarkCooper / IhabWahba / Kirstin Wingler and Harald HHWSchmidt / EnyuImai / WilliamMitch / Rebbeca Grysiewicz, Fernando Testai and PhilipGorelick First evaluation 26Mar2010 | Latest evaluation 21Jun2010 8 Exceptional F1000 Factor 10.2 Confirmation New Finding Controversial Refutation Stenting versus endarterectomy for treatment of carotid-artery stenosis. Brott TG, Hobson RW, , Meschia JF, CREST Investigators N Engl J Med 2010 Jul 1 363 (1):11-23 Selected by | NormanHertzer / Zirka H Anastasian and EricHeyer / Sunil Kumar and SripalBangalore / BoNorrving / PhilippaNewfield First evaluation 21Jun2010 | Latest evaluation 2Aug2010 9 Exceptional F1000 Factor 10.2 Hypothesis New Finding Circulating mitochondrial DAMPs cause inflammatory responses to injury. Zhang Q, Raoof M, , Itagaki K, Hauser CJ Nature 2010 Mar 4 464 (7285):104-7 Selected by | WilliamShafer / MichaelFessler / Gerard Curley and JohnLaffey / HelenaTlaskalova-Hogenova / WalterHasibeder First evaluation 25Mar2010 | Latest evaluation 6Jul2010 10 Exceptional F1000 Factor 10.2 Changes Clinical Practice Confirmation Hypothesis New Finding Fluvastatin and perioperative events in patients undergoing vascular surgery. Schouten O, Boersma E, , Poldermans D, Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress Echocardiography Study Group N Engl J Med 2009 Sep 3 361 (10):980-9 Selected by | BruceBiccard / SeemantChaturvedi / Jan Larmann and GregorTheilmeier / MarkNunnally / Nina Singh and JohnAugoustides First evaluation 25Sep2009 | Latest evaluation 11Jan2010
The F1000 Top 7 is a snapshot of the highest-ranked articles from a 30-day period on Faculty of 1000 Biology. Faculty Members evaluate and rate the most important papers in their field. To see the latest rankings, search the database, and read daily evaluations, visit http://f1000.com/ . Find Top 7s by searching for the IDs provided. Read more: TOP 7 FROM F1000 - The Scientist - Magazine of the Life Sciences http://www.the-scientist.com/article/display/57521/#ixzz0vDLMkPyF 请见 http://www.the-scientist.com/article/display/57521/
请进 http://www.the-scientist.com/blog/display/57563/ News: Top 7 immunology papers Posted by Edyta Zielinska Comment on this news story Read more: Top 7 immunology papers - The Scientist - Magazine of the Life Sciences http://www.the-scientist.com/blog/display/57563/#ixzz0uGZrhTle
请进 http://www.the-scientist.com/blog/display/57552/ News: Top 7 cell biology papers Posted by Jef Akst Comment on this news story Read more: Top 7 cell biology papers - The Scientist - Magazine of the Life Sciences http://www.the-scientist.com/blog/display/57552/#ixzz0uGYPugBs
http://www.the-scientist.com/article/display/57459/ The F1000 Top 7 is a snapshot of the highest-ranked articles from a 30-day period on Faculty of 1000 Biology. Faculty Members evaluate and rate the most important papers in their field. To see the latest rankings, search the database, and read daily evaluations, visit http://f1000.com/ . Find Top 7s by searching for the IDs provided. Read more: TOP 7 FROM F1000 - The Scientist - Magazine of the Life Sciences http://www.the-scientist.com/article/display/57459/#ixzz0sNW6lfUH
本周最新、最好的医学论文，必读的论文。 许推荐 详见： http://f1000medicine.com/home New articles this week 本周新论文 5 articles that change clinical practice 指导临床工作的5篇 13 existing articles with new evaluations 有评论的13篇 4 articles with an F1000 Factor above 6.0 F1000因子大于6的4篇 112 articles across all of medicine 全部医学论文 112篇 医学各学科最新、最好的论文 Latest articles in our specialties Anesthesiology Pain Management Cardiovascular Disorders Critical Care Emergency Medicine Dermatology Diabetes Endocrinology Gastroenterology Hepatology Hematology Infectious Diseases Nephrology Neurological Disorders Oncology Otolaryngology Psychiatry Public Health Epidemiology Research Methodology Respiratory Disorders Rheumatology Clinical Immunology Urology Women's Health The expert guide to the most important advances in medicine Explore the site to see which articles our global Faculty of over 2400 medical leaders have selected.
May 27, 2010 Top 7 from F1000 See the highest ranked papers from F1000 Biology By The Scientist Staff Naturally selected Ninety thousand ways to make you smarter By Sarah Greene Is this life? We're opening up our archives, and returning to our 2006 article on the progress and challenges of synthetic biology, in honor of last week's landmark announcement By Jack Lucentini How can I be sure? The Faculty's recent picks: sex and the single cell; mile high club; physician, heal thyself By Richard Grant miRNA makes cancer cells slick A miRNA associated with breast cancer inhibits E-cadherin expression, causing increased cell motility and invasiveness, yielding new insights into how the cancer spreads. Ma et al. 2010 Nat Cell Biol . Evaluated by A Migliaccio F Auricchio The diversity maker How a single transcription factor, Ste12, binds to DNA is behind the variation in phenotype that drives individual diversity in yeast. Gibson et al. 2010 Science . Evaluated by S Zeller B Schmid 10 retractions and counting A Mayo Clinic immunology lab has pulled 10 papers so far, with about five more expected, and cancelled a clinical trial By Jef Akst Senior Lancet editor sacked The cause, she says: Violating the confidentiality policy by distributing the draft version of a published (and edited) editorial By Bob Grant Death star A fax that Michael Hengartner sent to his mentor helped turn apoptosis into a Nobel Prize-winning pathway By Karen Hopkin Oil spill is boon to bacteria Effects of microbial proliferation up the food chain unknown By Bob Grant Data after death Most scientists don't think about what will happen to a lab after its PI dies until, tragically, they must By Jef Akst Misconduct case drags on Blood researcher fights to be reinstated at the University of Washington after a 7-year investigation By Jef Akst News in a nutshell DNA directs mutations; top 10 new species; CSI: dog poop By Alison McCook Billion-dollar babies The story of scientists who came up with ideas that recently convinced Pharma to give them millions of dollars By Jef Akst Digital upgrade How to choose your lab's next electronic lab notebook By Amber Dance
详细信息连接： http://f1000medicine.com/reports F1000 Medicine Reports The F1000 Medicine Reports (ISSN 1757-5931) journal publishes short commentaries by expert clinicians focussing on the most important studies identified by Faculty of 1000 that are likely to change clinical practice. The commentaries summarise the implications of important new research findings for clinicians. Latest Articles Gastroenterology Hepatology/Infectious Diseases/Oncology Management of Helicobacter pylori Seiji Shiota and Yoshio Yamaoka F1000 Medicine Reports 2010 , 2 : 20 (15 March 2010) Cardiovascular Disorders Recent advances in the management of hypertension Jos Antonio Garca-Donaire and Luis M Ruilope F1000 Medicine Reports 2010 , 2 : 19 (15 March 2010) Nephrology/Diabetes Endocrinology/Cardiovascular Disorders Renin angiotensin aldosterone system (RAAS) inhibitors in the prevention of early renal disease in diabetes Luigi Gnudi and David Goldsmith F1000 Medicine Reports 2010 , 2 : 18 (15 March 2010) Oncology Recent advances in managing human papillomavirus-positive oropharyngeal tumors Giulio Cantu, Stefano Riccio, Sarah Colombo, Madia Pompilio and Paolo Formillo F1000 Medicine Reports 2010 , 2 : 17 (15 March 2010) Hematology Recent advances in diagnosis and treatment of chronic myeloproliferative neoplasms Paola Guglielmelli and Alessandro M Vannucchi F1000 Medicine Reports 2010 , 2 : 16 (24 February 2010) Critical Care Emergency Medicine/Respiratory Disorders/Infectious Diseases Prevention of ventilator-associated pneumonia in adults Hallie C Prescott and James M O'Brien F1000 Medicine Reports 2010 , 2 : 15 (24 February 2010) Diabetes Endocrinology/Oncology Genetic screening for multiple endocrine neoplasia syndrome type 1 (MEN-1): when and how Alberto Falchetti F1000 Medicine Reports 2010 , 2 : 14 (24 February 2010) Respiratory Disorders Update on bioagent therapy in sarcoidosis Vincent Cottin F1000 Medicine Reports 2010 , 2 : 13 (24 February 2010) Hematology/Oncology Advances in cord blood transplants in adults Phuong L Doan and Nelson J Chao F1000 Medicine Reports 2010 , 2 : 12 (11 February 2010) Gastroenterology Hepatology/Infectious Diseases Recent advances in managing hepatitis B Brian J McMahon F1000 Medicine Reports 2010 , 2 : 11 (11 February 2010) Hematology/Cardiovascular Disorders/Respiratory Disorders Pulmonary hypertension in hemolytic anemias Shannon Wahl and Elliott Vichinsky F1000 Medicine Reports 2010 , 2 : 10 (11 February 2010) Urology Recent advances in management of bladder overactivity Ariana L Smith and Alan J Wein F1000 Medicine Reports 2010 , 2 : 9 (11 February 2010) Cardiology Recent advances in closure of atrial septal defects and patent foramen ovale Athar M Qureshi and Larry A Latson F1000 Medicine Reports 2010 , 2 : 8 (27 January 2010) Critical Care Emergency Medicine Diagnosing malabsorption in the intensive care unit Martijn B Keur, Albertus Beishuizen and Adriaan A van Bodegraven F1000 Medicine Reports 2010 , 2 : 7 (27 January 2010) Urology Intravesical botulinum toxin for lower urinary tract dysfunction Marcus John Drake F1000 Medicine Reports 2010 , 2 : 6 (27 January 2010) Hematology Platelet transfusions: trigger, dose, benefits, and risks Neil Blumberg, Joanna M Heal and Gordon L Phillips F1000 Medicine Reports 2010 , 2 : 5 (27 January 2010) Diabetes Endocrinology/Oncology Diabetes, insulin treatment, and cancer risk: what is the evidence? Madona Azar and Timothy J Lyons F1000 Medicine Reports 2010 , 2 : 4 (18 January 2010) Rheumatology Clinical Immunology Periodic fever syndrome and autoinflammatory diseases Laura J Dickie, Sinisa Savic, Azad Aziz, Michael Sprakes and Michael F McDermott F1000 Medicine Reports 2010 , 2 : 3 (18 January 2010) Infectious Diseases The diagnosis of coccidioidomycosis Neil M Ampel F1000 Medicine Reports 2010 , 2 : 2 (18 January 2010) Oncology/Urology/Nephrology Recent advances in focal therapy of prostate and kidney cancer Matvey Tsivian and Thomas J Polascik F1000 Medicine Reports 2010 , 2 : 1 (18 January 2010)
详细信息连接： http://f1000biology.com/reports/ F1000 Biology Reports The F1000 Biology Reports (ISSN 1757-594X) journal publishes short commentaries by the world's top scientists in which the hottest biology papers/clusters of papers identified by Faculty of 1000 are put into a broader context. Latest Articles Structural Biology/Cell Biology Recent advances in polyubiquitin chain recognition Hao Wu, Yu-Chih Lo and Su-Chang Lin F1000 Biology Reports 2010 , 2 : 20 (15 March 2010) Neuroscience Control of Schwann cell myelination Kristjn R Jessen and Rhona Mirsky F1000 Biology Reports 2010 , 2 : 19 (15 March 2010) Genomics Genetics/Cell Biology Mapping chromatin conformation Peter J Shaw F1000 Biology Reports 2010 , 2 : 18 (15 March 2010) Developmental Biology Recent advances in pancreas development: from embryonic pathways to programming renewable sources of beta cells Victoria E Prince and Mary D Kinkel F1000 Biology Reports 2010 , 2 : 17 (15 March 2010) Physiology The pathophysiology of diastolic heart failure Thanh Trung Phan and Michael Frenneaux F1000 Biology Reports 2010 , 2 : 16 (24 February 2010) Plant Biology Abscisic acid (ABA) receptors: light at the end of the tunnel Jorge Muschietti and Sheila McCormick F1000 Biology Reports 2010 , 2 : 15 (24 February 2010) Immunology Regulation of the IgE response Daniel H Conrad, David R Gibb and Jamie Sturgill F1000 Biology Reports 2010 , 2 : 14 (24 February 2010) Physiology/Neuroscience Stress and eating behaviour Achim Peters and Dirk Langemann F1000 Biology Reports 2010 , 2 : 13 (24 February 2010) Pharmacology Drug Discovery TRPV4 as a target for bladder overactivity Patrizia Angelico and Rodolfo Testa F1000 Biology Reports 2010 , 2 : 12 (11 February 2010) Genomics Genetics/Neuroscience Distinct disorders affecting the brain share common genetic origins R Frank Kooy F1000 Biology Reports 2010 , 2 : 11 (11 February 2010) Pharmacology Drug Discovery/Cell Biology PARP inhibitors in BRCA1/BRCA2 germline mutation carriers with ovarian and breast cancer Christina M Annunziata and Susan E Bates F1000 Biology Reports 2010 , 2 : 10 (11 February 2010) Plant Biology Recent advances in regulation of flowering Julin N Maloof F1000 Biology Reports 2010 , 2 : 9 (11 February 2010) Structural Biology RNA pseudoknots: folding and finding Biao Liu, David H Mathews and Douglas H Turner F1000 Biology Reports 2010 , 2 : 8 (27 January 2010) Plant Biology Recent advances in plant metabolomics and greener pastures Lloyd W Sumner F1000 Biology Reports 2010 , 2 : 7 (27 January 2010) Developmental Biology/Neuroscience Mechanisms of growth cone repulsion Catherine E Krull and Judith S Eisen F1000 Biology Reports 2010 , 2 : 6 (27 January 2010) Neuroscience Neuronal calcium sensor proteins: emerging roles in membrane traffic and synaptic plasticity Robert D Burgoyne and Lee P Haynes F1000 Biology Reports 2010 , 2 : 5 (27 January 2010) Neuroscience Dysfunction of the Ca V 2.1 calcium channel in cerebellar ataxias Sanjeev Rajakulendran, Stephanie Schorge, Dimitri M Kullmann and Michael G Hanna F1000 Biology Reports 2010 , 2 : 4 (18 January 2010) Immunology Ocular immune privilege Ru Zhou and Rachel R Caspi F1000 Biology Reports 2010 , 2 : 3 (18 January 2010) Neuroscience/Physiology Multiple functions of dopamine neurons Wolfram Schultz F1000 Biology Reports 2010 , 2 : 2 (18 January 2010) Ecology Eco-evolutionary dynamics: intertwining ecological and evolutionary processes in contemporary time Eric P Palkovacs and Andrew P Hendry F1000 Biology Reports 2010 , 2 : 1 (18 January 2010)
1 Must Read F1000 Factor 6.0 Hypothesis Complexity in biomaterials for tissue engineering. Place ES, Evans ND, Stevens MM Nat Mater 2009 Jun 8 (6):457-70 Selected by | AnthonyRatcliffe Evaluated 13Jan2010 2 Must Read F1000 Factor 6.0 Changes Clinical Practice Confirmation Cranberry and urinary tract infections. Guay DR Drugs 2009 69 (7):775-807 Selected by | Hana Edelstein and RaulRaz Evaluated 9Jun2009 3 Recommended F1000 Factor 3.0 Confirmation New Finding Neural grafts in Huntington's disease: viability after 10 years. Bachoud-Lvi AC Lancet Neurol 2009 Nov 8 (11):979-81 Selected by | Johannes Boltze and MichaelMoskowitz Evaluated 6Jan2010 4 Must Read F1000 Factor 6.0 New Finding Tobramycin and FDA-approved iron chelators eliminate Pseudomonas aeruginosa biofilms on cystic fibrosis cells. Moreau-Marquis S, O'Toole GA, Stanton BA Am J Respir Cell Mol Biol 2009 Sep 41 (3):305-13 Selected by | Katherine Hurt and DianaBilton Evaluated 27Nov2009 5 Recommended F1000 Factor 3.0 Confirmation University students' definitions of sexual abstinence and having sex. Byers ES, Henderson J, Hobson KM Arch Sex Behav 2009 Oct 38 (5):665-74 Selected by | StephenLevine Evaluated 6Jan2010 6 Recommended F1000 Factor 3.0 New Finding Evidence for aerobic ATP synthesis in isolated myelin vesicles. Ravera S, Panfoli I, , Mancardi G, Morelli A Int J Biochem Cell Biol 2009 Jul 41 (7):1581-91 Selected by | SalvatoreDi Mauro Evaluated 11Jan2010 7 Recommended F1000 Factor 3.0 Confirmation Hypothesis Effects of a Worksite Stress Management Training Program with Six Short-hour Sessions: A Controlled Trial among Japanese Employees. Umanodan R, Kobayashi Y, , Kawakami N, Shimazu A J Occup Health 2009 Jun 1 Selected by | NannaEller Evaluated 14Jul2009 8 Must Read F1000 Factor 6.0 New Finding Safety of the etonogestrel-releasing implant during the immediate postpartum period: a pilot study. Brito MB, Ferriani RA, , Silva de S MF, Vieira CS Contraception 2009 Dec 80 (6):519-26 Selected by | DavidHubacher Evaluated 7Jan2010 9 Recommended F1000 Factor 3.0 Confirmation Job stressors and long-term sick leave due to depressive disorders among Japanese male employees: findings from the Japan Work Stress and Health Cohort Study. Inoue A, Kawakami N, , Hashimoto S, Araki S J Epidemiol Community Health 2009 Aug 13 Selected by | Ida EH Madsen and ReinerRugulies Evaluated 15Oct2009 10 Recommended F1000 Factor 3.0 Hypothesis In the name of global health: trends in academic institutions. Macfarlane SB, Jacobs M, Kaaya EE J Public Health Policy 2008 Dec 29 (4):383-401
1 Must Read F1000 Factor 6.0 Hypothesis Complexity in biomaterials for tissue engineering. Place ES, Evans ND, Stevens MM Nat Mater 2009 Jun 8 (6):457-70 Selected by | AnthonyRatcliffe Evaluated 13Jan2010 2 Must Read F1000 Factor 6.0 Changes Clinical Practice Confirmation Cranberry and urinary tract infections. Guay DR Drugs 2009 69 (7):775-807 Selected by | Hana Edelstein and RaulRaz Evaluated 9Jun2009 3 Recommended F1000 Factor 3.0 Confirmation New Finding Neural grafts in Huntington's disease: viability after 10 years. Bachoud-Lvi AC Lancet Neurol 2009 Nov 8 (11):979-81 Selected by | Johannes Boltze and MichaelMoskowitz Evaluated 6Jan2010 4 Must Read F1000 Factor 6.0 New Finding Tobramycin and FDA-approved iron chelators eliminate Pseudomonas aeruginosa biofilms on cystic fibrosis cells. Moreau-Marquis S, O'Toole GA, Stanton BA Am J Respir Cell Mol Biol 2009 Sep 41 (3):305-13 Selected by | Katherine Hurt and DianaBilton Evaluated 27Nov2009 5 Recommended F1000 Factor 3.0 Confirmation University students' definitions of sexual abstinence and having sex. Byers ES, Henderson J, Hobson KM Arch Sex Behav 2009 Oct 38 (5):665-74 Selected by | StephenLevine Evaluated 6Jan2010 6 Recommended F1000 Factor 3.0 New Finding Evidence for aerobic ATP synthesis in isolated myelin vesicles. Ravera S, Panfoli I, , Mancardi G, Morelli A Int J Biochem Cell Biol 2009 Jul 41 (7):1581-91 Selected by | SalvatoreDi Mauro Evaluated 11Jan2010 7 Recommended F1000 Factor 3.0 Confirmation Hypothesis Effects of a Worksite Stress Management Training Program with Six Short-hour Sessions: A Controlled Trial among Japanese Employees. Umanodan R, Kobayashi Y, , Kawakami N, Shimazu A J Occup Health 2009 Jun 1 Selected by | NannaEller Evaluated 14Jul2009 8 Must Read F1000 Factor 6.0 New Finding Safety of the etonogestrel-releasing implant during the immediate postpartum period: a pilot study. Brito MB, Ferriani RA, , Silva de S MF, Vieira CS Contraception 2009 Dec 80 (6):519-26 Selected by | DavidHubacher Evaluated 7Jan2010 9 Exceptional F1000 Factor 9.0 Hypothesis New Finding Controversial On cricoid pressure: may the force be with you. Lerman J Anesth Analg 2009 Nov 109 (5):1363-6 Selected by | ZulfiqarAhmed Evaluated 1Dec2009 10 Recommended F1000 Factor 3.0 Confirmation Job stressors and long-term sick leave due to depressive disorders among Japanese male employees: findings from the Japan Work Stress and Health Cohort Study. Inoue A, Kawakami N, , Hashimoto S, Araki S J Epidemiol Community Health 2009 Aug 13 Selected by | Ida EH Madsen and ReinerRugulies Evaluated 15Oct2009
1 Recommended F1000 Factor 3.0 Changes Clinical Practice New Finding Expand the pharyngitis paradigm for adolescents and young adults. Centor RM Ann Intern Med 2009 Dec 1 151 (11):812-5 Selected by | Maria T Perez and LarryBush Evaluated 6Jan2010 2 Must Read F1000 Factor 6.0 Hypothesis Complexity in biomaterials for tissue engineering. Place ES, Evans ND, Stevens MM Nat Mater 2009 Jun 8 (6):457-70 Selected by | AnthonyRatcliffe Evaluated 13Jan2010 3 Must Read F1000 Factor 6.0 Changes Clinical Practice Confirmation Cranberry and urinary tract infections. Guay DR Drugs 2009 69 (7):775-807 Selected by | Hana Edelstein and RaulRaz Evaluated 9Jun2009 4 Recommended F1000 Factor 3.0 Confirmation New Finding Neural grafts in Huntington's disease: viability after 10 years. Bachoud-Lvi AC Lancet Neurol 2009 Nov 8 (11):979-81 Selected by | Johannes Boltze and MichaelMoskowitz Evaluated 6Jan2010 5 Must Read F1000 Factor 6.0 New Finding Tobramycin and FDA-approved iron chelators eliminate Pseudomonas aeruginosa biofilms on cystic fibrosis cells. Moreau-Marquis S, O'Toole GA, Stanton BA Am J Respir Cell Mol Biol 2009 Sep 41 (3):305-13 Selected by | Katherine Hurt and DianaBilton Evaluated 27Nov2009 6 Recommended F1000 Factor 3.0 Confirmation University students' definitions of sexual abstinence and having sex. Byers ES, Henderson J, Hobson KM Arch Sex Behav 2009 Oct 38 (5):665-74 Selected by | StephenLevine Evaluated 6Jan2010 7 Recommended F1000 Factor 3.0 New Finding Evidence for aerobic ATP synthesis in isolated myelin vesicles. Ravera S, Panfoli I, , Mancardi G, Morelli A Int J Biochem Cell Biol 2009 Jul 41 (7):1581-91 Selected by | SalvatoreDi Mauro Evaluated 11Jan2010 8 Recommended F1000 Factor 3.0 Confirmation Hypothesis Effects of a Worksite Stress Management Training Program with Six Short-hour Sessions: A Controlled Trial among Japanese Employees. Umanodan R, Kobayashi Y, , Kawakami N, Shimazu A J Occup Health 2009 Jun 1 Selected by | NannaEller Evaluated 14Jul2009 9 Exceptional F1000 Factor 9.0 Hypothesis New Finding Controversial On cricoid pressure: may the force be with you. Lerman J Anesth Analg 2009 Nov 109 (5):1363-6 Selected by | ZulfiqarAhmed Evaluated 1Dec2009 10 Must Read F1000 Factor 6.0 New Finding Safety of the etonogestrel-releasing implant during the immediate postpartum period: a pilot study. Brito MB, Ferriani RA, , Silva de S MF, Vieira CS Contraception 2009 Dec 80 (6):519-26
1 Exceptional F1000 Factor 12.6 Changes Clinical Practice Confirmation Hypothesis New Finding Controversial Refutation Intensive versus conventional glucose control in critically ill patients. Finfer S, Chittock DR, , Robinson BG, Ronco JJ N Engl J Med 2009 Mar 26 360 :1283-97 Selected by | BenediktPreckel / WalterHasibeder / Jean-CharlesPreiser / NicholasBarrett / NigelWebster / Emine Aysu Salviz and AlainVuylsteke / Jacobo Sellares and AntoniTorres / GregMartin / Patrice Forget and MarcDe Kock / JohnLaffey / Jose Pascual and BabakSarani / Priya Shah and SethField / BruceBistrian / Ashish Sinha and JohnAugoustides / Regina Schumann and ManfredSeeberger First evaluation 31Mar2009 | Latest evaluation 11Aug2009 2 Exceptional F1000 Factor 12.1 Confirmation New Finding Dabigatran versus warfarin in patients with atrial fibrillation. Connolly SJ, Ezekowitz MD, , Wallentin L, RE-LY Steering Committee and Investigators N Engl J Med 2009 Sep 17 361 (12):1139-51 Selected by | RobertRuff / Rakesh Gopinathannair and BrianOlshansky / Jos A Garca Donaire and LuisRuilope / WilbertAronow / Sung Ham and FredWeaver / Fernando Testai and PhilipGorelick / Guy Amit and I EliOvsyshcher / Anna Maria Choy and ChimLang / HeatherBloom / HarriJenkins / WolfgangSchoels / AshfaqShuaib / Aleksandra Pikula and CarlosKase First evaluation 7Sep2009 | Latest evaluation 4Jan2010 3 Exceptional F1000 Factor 11.5 Changes Clinical Practice Confirmation Hypothesis New Finding Controversial Refutation Anesthesia awareness and the bispectral index. Avidan MS, Zhang L, , Jacobsohn E, Evers AS N Engl J Med 2008 Mar 13 358 (11):1097-108 Selected by | VesnaJevtovic-Todorovic / PhilippaNewfield / BeverleyOrser / EmeryBrown / HaraldGroeben / BenediktPannen / ManfredSeeberger / AlainBorgeat / LyndaWells / DhaneshGupta / Serene Leo and AlexSia / PaulBarash / MichaelO'Connor / MasahikoKawaguchi Dissenters | Elise Sarton and AlbertDahan / Seppo Alahuhta and VilleJantti Author Response | Avidan MS, Zhang L, Burnside BA, Finkel KJ, Searleman AC, Selvidge JA, Saager L, Turner MS, Rao S, Bottros M, Hantler C, Jacobsohn E, Evers AS. B-Unaware Trial Group / Avidan et al. / Avidan et al. / Avidan et al. / Avidan et al. / Avidan et al. / Avidan et al. / Avidan et al. / Avidan et al. / Avidan et al. / Avidan et al. / Avidan et al. / Avidan et al. / Avidan et al. First evaluation 18Mar2008 | Latest evaluation 11Jun2008 4 Exceptional F1000 Factor 11.2 Confirmation Hypothesis New Finding Tech Advance Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers. Binshtok AM, Bean BP, Woolf CJ Nature 2007 Oct 4 449 (7162):607-10 Selected by | MishaPerouansky / NannaFinnerup / HughHemmings / EmeryBrown / HelgeEilers / DavidArcher / Daniel Vilceanu and CherylStucky / MichaelSchaefer First evaluation 23Oct2007 | Latest evaluation 13Mar2008 5 Exceptional F1000 Factor 10.7 Changes Clinical Practice Confirmation New Finding Treatment of hypertension in patients 80 years of age or older. Beckett NS, Peters R, , Bulpitt CJ, HYVET Study Group N Engl J Med 2008 May 1 358 (18):1887-98 Selected by | Dharam Kumbhani and DeepakBhatt / Ramachandran S.Vasan / JeromeFleg / AnnemarieHennessy / ErnestoSchiffrin / WilbertAronow / Joji Ishikawa and KazuomiKario First evaluation 14Apr2008 | Latest evaluation 3Jun2008 6 Exceptional F1000 Factor 10.5 Changes Clinical Practice Confirmation Hypothesis New Finding Controversial Refutation Intensity of renal support in critically ill patients with acute kidney injury. VA/NIH Acute Renal Failure Trial Network, Palevsky PM, , Star RA, Peduzzi P N Engl J Med 2008 Jul 3 359 (1):7-20 Selected by | AchimJoerres / AndrewDavenport / JohnLaffey / GregMartin / Arrigo Schieppati and GiuseppeRemuzzi / HeleenOudemans-van Straaten / WilliamMitch First evaluation 2Jun2008 | Latest evaluation 14Aug2008 7 Exceptional F1000 Factor 10.2 Changes Clinical Practice Confirmation Hypothesis New Finding Fluvastatin and perioperative events in patients undergoing vascular surgery. Schouten O, Boersma E, , Poldermans D, Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress Echocardiography Study Group N Engl J Med 2009 Sep 3 361 (10):980-9 Selected by | BruceBiccard / SeemantChaturvedi / Jan Larmann and GregorTheilmeier / MarkNunnally / Nina Singh and JohnAugoustides First evaluation 25Sep2009 | Latest evaluation 11Jan2010 8 Exceptional F1000 Factor 10.2 Confirmation Hypothesis New Finding Tech Advance Clonal integration of a polyomavirus in human Merkel cell carcinoma. Feng H, Shuda M, Chang Y, Moore PS Science 2008 Feb 22 319 (5866):1096-100 Selected by | SabineKohler / Karola Stieler and UlrikeBlume-Peytavi / IsaacNeuhaus / JuergenBecker / JaneSterling First evaluation 31Jan2008 | Latest evaluation 12Nov2008 9 Exceptional F1000 Factor 10.2 Changes Clinical Practice Confirmation Hypothesis New Finding Controversial Comparison of two fluid-management strategies in acute lung injury. National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network, Wiedemann HP, , Hite RD, Harabin AL N Engl J Med 2006 Jun 15 354 (24):2564-75 Selected by | Lynne WarnerStevenson / JacquesLacroix / GregMartin / MichaelGropper / JacobSznajder First evaluation 10Aug2006 | Latest evaluation 22May2007 10 Exceptional F1000 Factor 10.1 Confirmation Hypothesis New Finding Controversial Refutation Placental transfer and fetal metabolic effects of phenylephrine and ephedrine during spinal anesthesia for cesarean delivery. Ngan Kee WD, Khaw KS, , Ng FF, Karmakar MK Anesthesiology 2009 Sep 111 (3):506-12 Selected by | BernardWittels / Tanya Jones and RoshanFernando / Serene Leo and AlexSia / Nicole Higgins and JohnSullivan / SumioHoka First evaluation 9Sep2009 | Latest evaluation 2Dec2009
1 Exceptional F1000 Factor 9.0 Confirmation New Finding Controversial Duration and magnitude of the postoperative risk of venous thromboembolism in middle aged women: prospective cohort study. Sweetland S, Green J, , Beral V, Million Women Study collaborators BMJ 2009 339 :b4583 Selected by | ThomasSlaughter Evaluated 14Jan2010 2 Exceptional F1000 Factor 9.0 Hypothesis Salt-sensitive hypertension in circadian clock-deficient Cry-null mice involves dysregulated adrenal Hsd3b6. Doi M, Takahashi Y, , van der Horst GT, Okamura H Nat Med 2009 Dec 13 Selected by | Scott MacKenzie and EleanorDavies Evaluated 5Jan2010 3 Exceptional F1000 Factor 9.0 New Finding Preventing the return of fear in humans using reconsolidation update mechanisms. Schiller D, Monfils MH, , Ledoux JE, Phelps EA Nature 2009 Dec 9 Selected by | Francisco Sotres-Bayon and Gregory JQuirk Evaluated 4Jan2010 4 Exceptional F1000 Factor 9.0 Hypothesis New Finding Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: a report from the PROMID Study Group. Rinke A, Mller HH, , Arnold R, PROMID Study Group J Clin Oncol 2009 Oct 1 27 (28):4656-63 Selected by | AaronVinik Evaluated 4Jan2010 5 Must Read F1000 Factor 6.4 Confirmation New Finding Effect of mannitol and hypertonic saline on cerebral oxygenation in patients with severe traumatic brain injury and refractory intracranial hypertension. Oddo M, Levine JM, , Mayer SA, LeRoux PD J Neurol Neurosurg Psychiatry 2009 Aug 80 (8):916-20 Selected by | MartinSmith / DonaldMarion Dissenters | ElfynThomas First evaluation 5Jan2010 | Latest evaluation 12Jan2010 6 Must Read F1000 Factor 6.4 Confirmation Hypothesis New Finding Controversial Refutation Intravenous drug administration during out-of-hospital cardiac arrest: a randomized trial. Olasveengen TM, Sunde K, , Steen PA, Wik L JAMA 2009 Nov 25 302 (20):2222-9 Selected by | ThomasSlaughter / PatrickRay First evaluation 6Jan2010 | Latest evaluation 7Jan2010 7 Must Read F1000 Factor 6.0 Refutation A Randomized, Controlled Trial of Computer-Assisted Cognitive Remediation for Schizophrenia. Dickinson D, Tenhula W, , Gold JM, Bellack AS Am J Psychiatry 2009 Dec 15 Selected by | Tara Niendam and J DanielRagland Evaluated 15Jan2010 8 Must Read F1000 Factor 6.0 New Finding iPS cells can support full-term development of tetraploid blastocyst-complemented embryos. Kang L, Wang J, , Kou Z, Gao S Cell Stem Cell 2009 Aug 7 5 (2):135-8 Selected by | LaurieZoloth Evaluated 15Jan2010 9 Must Read F1000 Factor 6.0 Confirmation Validity of the FOUR score coma scale in the medical intensive care unit. Iyer VN, Mandrekar JN, , Elmer JL, Wijdicks EF Mayo Clin Proc 2009 Aug 84 (8):694-701 Selected by | JoseBiller Evaluated 15Jan2010 10 Must Read F1000 Factor 6.0 Confirmation Effects of high-dose versus low-dose losartan on clinical outcomes in patients with heart failure (HEAAL study): a randomised, double-blind trial. Konstam MA, Neaton JD, , Poole-Wilson PA, HEAAL Investigators Lancet 2009 Nov 28 374 (9704):1840-8
http://f1000biology.com/reports/ F1000 Biology Reports 17 January 2010 The F1000 Biology Reports (ISSN 1757-594X) journal publishes short commentaries by the world's top scientists in which the hottest biology papers/clusters of papers identified by Faculty of 1000 are put into a broader context. Latest Articles Cell Biology Brd4 engagement from chromatin targeting to transcriptional regulation: selective contact with acetylated histone H3 and H4 Cheng-Ming Chiang F1000 Biology Reports 2009 , 1 : 98 (15 December 2009) Immunology Natural killer T cell recognition of lipid antigens Luc Teyton F1000 Biology Reports 2009 , 1 : 97 (15 December 2009) Cell Biology Putative functions of caspase-2 Loretta Dorstyn and Sharad Kumar F1000 Biology Reports 2009 , 1 : 96 (15 December 2009) Genomics Genetics/Microbiology CRISPR-Cas: an adaptive immunity system in prokaryotes Eugene V Koonin and Kira S Makarova F1000 Biology Reports 2009 , 1 : 95 (9 December 2009) Ecology Current themes and recent advances in modelling species occurrences Graeme S Cumming F1000 Biology Reports 2009 , 1 : 94 (9 December 2009) Cell Biology/Plant Biology Aberrant mRNA transcripts and nonsense-mediated decay Laura Trinkle-Mulcahy F1000 Biology Reports 2009 , 1 : 93 (9 December 2009) Genomics Genetics/Cell Biology/Developmental Biology Insulators: linking genome architecture to gene regulation Robert AH White F1000 Biology Reports 2009 , 1 : 92 (9 December 2009) Chemical Biology/Genomics Genetics/Structural Biology Prediction of function in protein superfamilies Shelley D Copley F1000 Biology Reports 2009 , 1 : 91 (9 December 2009) Cell Biology Telomeric RNAs as a novel player in telomeric integrity Olaf Isken and Lynne E Maquat F1000 Biology Reports 2009 , 1 : 90 (26 November 2009) Immunology/Microbiology HIV vaccination: turning the spotlight on effector memory T cells as mucosal gatekeepers Hilde Cheroutre F1000 Biology Reports 2009 , 1 : 89 (26 November 2009) Chemical Biology/Structural Biology Unnatural amino acids: better than the real things? Ellen C Minnihan, Kenichi Yokoyama and JoAnne Stubbe F1000 Biology Reports 2009 , 1 : 88 (26 November 2009) Pharmacology Drug Discovery/Structural Biology Biased agonism Terry Kenakin F1000 Biology Reports 2009 , 1 : 87 (26 November 2009) Genomics Genetics/Cell Biology A direct measurement of crossing over in human prophase oocytes R Scott Hawley F1000 Biology Reports 2009 , 1 : 86 (16 November 2009) Physiology/Neuroscience The evolving story of orexin biology: the hits keep coming Willis K Samson F1000 Biology Reports 2009 , 1 : 85 (16 November 2009) Cell Biology/Developmental Biology Induced pluripotent stem (iPS) cells: an up-to-the-minute review Frank Lau, Tim Ahfeldt, Kenji Osafune, Hidenori Akustsu and Chad A Cowan F1000 Biology Reports 2009 , 1 : 84 (16 November 2009) Cell Biology An old dog learns new tricks: novel functions of the exocyst complex in polarized epithelia in animals Richard S Kang and Heike Flsch F1000 Biology Reports 2009 , 1 : 83 (16 November 2009) Ecology Evaluation of global change impacts on diffuse pollution Gilles Pinay and David M Hannah F1000 Biology Reports 2009 , 1 : 82 (29 October 2009) Neuroscience Transcranial magnetic stimulation studies of visuospatial attentional control Sara M Szczepanski and Sabine Kastner F1000 Biology Reports 2009 , 1 : 81 (29 October 2009) Immunology/Microbiology Genetic reprogramming of host cells by bacterial pathogens Guy Tran Van Nhieu and Laurence Arbibe F1000 Biology Reports 2009 , 1 : 80 (29 October 2009) Cell Biology/Pharmacology Drug Discovery Inhibitor of Apoptosis (IAP) proteins as drug targets for the treatment of cancer David L Vaux F1000 Biology Reports 2009 , 1 : 79 (29 October 2009) Neuroscience Music drives brain plasticity Lutz Jncke F1000 Biology Reports 2009 , 1 : 78 (14 October 2009) Pharmacology Drug Discovery/Structural Biology Bitopic ligands: all-in-one orthosteric and allosteric Maud Kamal and Ralf Jockers F1000 Biology Reports 2009 , 1 : 77 (14 October 2009) Cell Biology/Genomics Genetics When transcription meets recombination: a lesson from the human RECQ protein complexes Yilun Liu and Joan W Conaway F1000 Biology Reports 2009 , 1 : 76 (14 October 2009) Physiology 'Functional' body composition: differentiating between benign and non-benign obesity Manfred J Mller, Anja Bosy-Westphal, Martin Heller F1000 Biology Reports 2009 , 1 : 75 (14 October 2009) Neuroscience The posterior parietal cortex and non-spatial cognition Yumiko Yamazaki, Teruo Hashimoto and Atsushi Iriki F1000 Biology Reports 2009 , 1 : 74 (28 September 2009) Genomics Genetics/Pharmacology Drug Discovery Customized care 2020: how medical sequencing and network biology will enable personalized medicine Mark S Boguski, Ramy Arnaout and Colin Hill F1000 Biology Reports 2009 , 1 : 73 (28 September 2009) Cell Biology/Structural Biology Conformational changes in receptor tyrosine kinase signaling: an ErbB garden of delights Kermit L Carraway and Goldi A Kozloski F1000 Biology Reports 2009 , 1 : 72 (28 September 2009) Microbiology HIV-1 host interactions: integration of large-scale datasets Amalio Telenti F1000 Biology Reports 2009 , 1 : 71 (28 September 2009) Pharmacology Drug Discovery/Immunology Targeting cytokines in inflammatory diseases: focus on interleukin-1-mediated autoinflammation George D Kalliolias and Lionel B Ivashkiv F1000 Biology Reports 2009 , 1 : 70 (14 September 2009) Structural Biology Diversity of protein structures and difficulties in fold recognition: the curious case of protein G Jeremy Horst and Ram Samudrala F1000 Biology Reports 2009 , 1 : 69 (14 September 2009) Cell Biology The roles, mechanisms, and controversies of autophagy in mammalian biology Russell G Jones F1000 Biology Reports 2009 , 1 : 68 (14 September 2009) Immunology/Cell Biology Integrin-independent movement of immune cells Sophie E Pinner and Erik Sahai F1000 Biology Reports 2009 , 1 : 67 (14 September 2009) Neuroscience Setting the absolute threshold of vision Alapakkam P Sampath and Gordon L Fain F1000 Biology Reports 2009 , 1 : 66 (26 August 2009) Cell Biology Vesicle coating and uncoating: controlling the formation of large COPII-coated carriers Anna K Townley and David J Stephens F1000 Biology Reports 2009 , 1 : 65 (26 August 2009) Microbiology Do apicomplexan parasite-encoded proteins act as both ligands and receptors during host cell invasion? Paul R Gilson and Brendan S Crabb F1000 Biology Reports 2009 , 1 : 64 (26 August 2009) Physiology Depression and metabolism: linking changes in leptin and ghrelin to mood Michael Lutter and Joel Elmquist F1000 Biology Reports 2009 , 1 : 63 (26 August 2009) Microbiology Cryptococcus gattii outbreak expands into the Northwestern United States with fatal consequences Edmond J Byrnes III and Joseph Heitman F1000 Biology Reports 2009 , 1 : 62 (17 August 2009) Neuroscience/Immunology Autoimmune channelopathies: new antibody-mediated disorders of the central nervous system Angela Vincent F1000 Biology Reports 2009 , 1 : 61 (17 August 2009) Immunology Thymic egress: S1P of 1000 Marcus A Zachariah and Jason G Cyster F1000 Biology Reports 2009 , 1 : 60 (17 August 2009) Developmental Biology/Cell Biology Intracellular trafficking and signaling in development Daniel B Constam F1000 Biology Reports 2009 , 1 : 59 (17 August 2009) Cell Biology/Neuroscience Cell biology of mechanotransduction in inner-ear hair cells David P Corey F1000 Biology Reports 2009 , 1 : 58 (27 July 2009) Plant Biology The dark side of clock-controlled flowering Vicente Rubio and Xing Wang Deng F1000 Biology Reports 2009 , 1 : 57 (27 July 2009) Neuroscience/Developmental Biology Development of object recognition in humans Mayu Nishimura, Suzy Scherf and Marlene Behrmann F1000 Biology Reports 2009 , 1 : 56 (27 July 2009) Immunology Two mechanisms that account for major histocompatibility complex restriction of T cells David M Kranz F1000 Biology Reports 2009 , 1 : 55 (27 July 2009) Neuroscience A current view of Alzheimer's disease Basavaraj V Hooli and Rudolph E Tanzi F1000 Biology Reports 2009 , 1 : 54 (08 July 2009) Chemical Biology/Pharmacology Drug Discovery Using the ribosome to synthesize peptidomimetics Roger M Freidinger F1000 Biology Reports 2009 , 1 : 53 (08 July 2009) Cell Biology Microtubule motors: moving forward on many fronts Viki Allan F1000 Biology Reports 2009 , 1 : 52 (08 July 2009) Structural Biology Molecular dynamics-based approaches for enhanced sampling of long-time, large-scale conformational changes in biomolecules Tamar Schlick F1000 Biology Reports 2009 , 1 : 51 (08 July 2009) Microbiology/Immunology Lessons from the failure of the adenovector HIV vaccine Marie-Eve Blais and Sarah Rowland-Jones F1000 Biology Reports 2009 , 1 : 50 (29 June 2009) Developmental Biology Clearance of germ granules in the soma Asako Sugimoto F1000 Biology Reports 2009 , 1 : 49 (29 June 2009) Structural Biology Monte Carlo, harmonic approximation, and coarse-graining approaches for enhanced sampling of biomolecular structure Tamar Schlick F1000 Biology Reports 2009 , 1 : 48 (29 June 2009) Plant Biology The role of malate in plant homeostasis Iris Finkemeier and Lee J Sweetlove F1000 Biology Reports 2009 , 1 : 47 (29 June 2009) Neuroscience/Physiology Purinergic cotransmission Geoffrey Burnstock F1000 Biology Reports 2009 , 1 : 46 (09 June 2009) Plant Biology Shaping the meristem by mechanical forces Patrick Laufs, Alexis Peaucelle and Herman Hfte F1000 Biology Reports 2009 , 1 : 45 (09 June 2009) Ecology Extinction risks from climate change: macroecological and historical insights Roland Jansson F1000 Biology Reports 2009 , 1 : 44 (09 June 2009) Ecology Evolutionary impacts of fishing: overfishing's 'Darwinian debt' John M Pandolfi F1000 Biology Reports 2009 , 1 : 43 (09 June 2009) Immunology/Physiology Role of neuropeptides, hormones, and growth factors in regulating thymopoiesis in middle to old age Kalpesh Patel and Dennis D Taub F1000 Biology Reports 2009 , 1 : 42 (28 May 2009) Structural Biology Osmolyte solutions and protein folding Char Y Hu, B Montgomery Pettitt and Joerg Roesgen F1000 Biology Reports 2009 , 1 : 41 (28 May 2009) Pharmacology Drug Discovery New antibiotics for antibiotic-resistant bacteria William Stubbings and Harald Labischinski F1000 Biology Reports 2009 , 1 : 40 (28 May 2009) Immunology B cell-targeted therapies in autoimmunity: rationale and progress Paolo Fiorina and Mohamed H Sayegh F1000 Biology Reports 2009 , 1 : 39 (28 May 2009) Structural Biology Describing protein conformational ensembles: beyond static snapshots George N Phillips, Jr F1000 Biology Reports 2009 , 1 : 38 (08 May 2009) Structural Biology/Chemical Biology Detailed mechanism for transposition by TnpA transposase involves DNA -shape rather than direct protein-DNA recognition to generate an active nucleoprotein complex P Shing Ho F1000 Biology Reports 2009 , 1 : 37 (08 May 2009) Ecology The consequences of human-driven ocean acidification for marine life Scott Doney F1000 Biology Reports 2009 , 1 : 36 (08 May 2009) Genomics Genetics/Pharmacology Drug Discovery Emerging technologies for the genomic analysis of cancer John Nemunaitis and Neil N Senzer F1000 Biology Reports 2009 , 1 : 35 (08 May 2009) Microbiology Electron transport chains of lactic acid bacteria - walking on crutches is part of their lifestyle Rob Brooijmans, Willem M de Vos, and Jeroen Hugenholtz F1000 Biology Reports 2009 , 1 : 34 (29 April 2009) Genomics Genetics/Cell Biology Ubiquitous antisense transcription in eukaryotes: novel regulatory mechanism or byproduct of opportunistic RNA polymerase? Justin H Layer and P Anthony Weil F1000 Biology Reports 2009 , 1 : 33 (29 April 2009) Genomics Genetics Applications of high-throughput sequencing to chromatin structure and function in mammals Ian Dunham F1000 Biology Reports 2009 , 1 : 32 (29 April 2009) Plant Biology Long-distance transport of macromolecules through the phloem Julia Kehr F1000 Biology Reports 2009 , 1 : 31 (29 April 2009) Microbiology/Immunology The role of microbial polysaccharides in host-pathogen interaction David Corbett and Ian S. Roberts F1000 Biology Reports 2009 , 1 : 30 (29 April 2009) Cell Biology/Chemical Biology Single-molecule dynamics of nuclear mRNA Yaron Shav-Tal and Yosef Gruenbaum F1000 Biology Reports 2009 , 1 : 29 (29 April 2009) Immunology A novel mucosal RORt+NKp46+ cell subset is a source of interleukin-22 Elena Tomasello, Ana Reynders and Eric Vivier F1000 Biology Reports 2009 , 1 : 28 (29 April 2009) Neuroscience/Developmental Biology The growth cone: an integrator of unique cues into refined axon guidance Sophie Chauvet and Genevive Rougon F1000 Biology Reports 2009 , 1 : 27 (29 April 2009) Ecology Toward understanding the effect of top predators on ecosystems Nicolas Lecomte, Dorothe Ehrich, Rolf A Ims and Nigel G Yoccoz F1000 Biology Reports 2009 , 1 : 26 (24 March 2009) Genomics Genetics/Microbiology Bioinformatic detection of horizontally transferred DNA in bacterial genomes Morgan GI Langille and Fiona SL Brinkman F1000 Biology Reports 2009 , 1 : 25 (24 March 2009) Structural Biology Nuclear magnetic resonance captures the elusive Steven R Van Doren F1000 Biology Reports 2009 , 1 : 24 (24 March 2009) Neuroscience/Pharmacology Drug Discovery The ABCB1 transporter gene and antidepressant response Eric J Peters, Victor Reus and Steven P Hamilton F1000 Biology Reports 2009 , 1 : 23 (24 March 2009) Microbiology Latest advances in innate antiviral defence Aaron Irving and Bryan RG Williams F1000 Biology Reports 2009 , 1 : 22 (17 March 2009) Cell Biology 'A mover and a shaker': 53BP1 allows DNA doublestrand breaks a chance to dance and unite Aaron A Goodarzi and Penny A Jeggo F1000 Biology Reports 2009 , 1 : 21 (17 March 2009) Developmental Biology Breaking the A chain: regulating mRNAs in development through CCR4 deadenylase Jocelyn Moore and Paul Lasko F1000 Biology Reports 2009 , 1 : 20 (17 March 2009) Structural Biology/Chemical Biology All change: protein conformation and the ubiquitination reaction cascade Christiane Riedinger and Jane A Endicott F1000 Biology Reports 2009 , 1 : 19 (17 March 2009) Pharmacology Drug Discovery/Microbiology Malarial parasite pathogenesis and drug targets Paul D Roepe F1000 Biology Reports 2009 , 1 : 18 (24 February 2009) Cell Biology Mitochondria and apoptosis: a quick take on a long view Melissa J Parsons and Douglas R Green F1000 Biology Reports 2009 , 1 : 17 (24 February 2009) Ecology Climate change and biodiversity conservation: impacts, adaptation strategies and future research directions Shannon M Hagerman and Kai MA Chan F1000 Biology Reports 2009 , 1 : 16 (24 February 2009) Immunology The inflammasome and alum-mediated adjuvanticity Suk-Jo Kang and Richard M Locksley F1000 Biology Reports 2009 , 1 : 15 (24 February 2009) Plant Biology Trace elements: too little or too much and how plants cope Joe Morrissey and Mary Lou Guerinot F1000 Biology Reports 2009 , 1 : 14 (24 February 2009) Cell Biology Regulatory roles of the cadherin superfamily Robert Harmon, Bhushan Desai and Kathleen Green F1000 Biology Reports 2009 , 1 : 13 (24 February 2009) Microbiology/Immunology Recent strategies to identify broadly neutralizing antibodies against influenza A virus Donna M Tscherne and Adolfo Garca-Sastre F1000 Biology Reports 2009 , 1 : 12 (24 February 2009) Structural Biology G-protein-coupled receptor structure: what can we learn? Andrew B Tobin F1000 Biology Reports 2009 , 1 : 11 (24 February 2009) Physiology Central control of feeding Kristin A Anderson and Anthony R Means F1000 Biology Reports 2009 , 1 : 10 (21 January 2009) Microbiology/Immunology Gut commensal flora: tolerance and homeostasis Maria Rescigno F1000 Biology Reports 2009 , 1 : 9 (21 January 2009) Pharmacology Drug Discovery/Cell Biology Regulation of the mTOR signaling pathway: from laboratory bench to bedside and back again Robert T Abraham F1000 Biology Reports 2009 , 1 : 8 (21 January 2009) Structural Biology Implications of the RecA structure Edward H Egelman F1000 Biology Reports 2009 , 1 : 7 (21 January 2009) Structural Biology The unforeseeable hammerhead ribozyme Christian Hammann and Eric Westhof F1000 Biology Reports 2009 , 1 : 6 (21 January 2009) Immunology Duality in the Th17-Treg developmental decision Robin D Hatton and Casey T Weaver F1000 Biology Reports 2009 , 1 : 5 (21 January 2009) Cell Biology Roles of the small GTPases RhoA and Rac1 in cell behavior Carol Otey, Silvia Goicoechea and Rafael Garcia-Mata F1000 Biology Reports 2009 , 1 : 4 (21 January 2009) Neuroscience Sources of the spatial code within the hippocampus Mark P Brandon and Michael E Hasselmo F1000 Biology Reports 2009 , 1 : 3 (21 January 2009) Immunology Alternative macrophage activation and the regulation of metabolism Paul Webb F1000 Biology Reports 2009 , 1 : 2 (21 January 2009) Neuroscience/Developmental Biology Recent advances in neural development Clemens Kiecker and Andrew Lumsden F1000 Biology Reports 2009 , 1 : 1 (21 January 2009) var gaJsHost = (("https:" == document.location.protocol) ? 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