Brian Haynes MD, Editor, Evidence Updates # Article Title 1 Amitriptyline for neuropathic pain and fibromyalgia in adults. Cochrane Database Syst Rev 2 Effects of Metformin Versus Glipizide on Cardiovascular Outcomes in Patients With Type 2 Diabetes and Coronary Artery Disease. Diabetes Care 3 Transfusion strategies for acute upper gastrointestinal bleeding. N Engl J Med 4 Selective serotonin reuptake inhibitors during pregnancy and risk of stillbirth and infant mortality. JAMA 5 Effect of vitamin D supplementation on progression of knee pain and cartilage volume loss in patients with symptomatic osteoarthritis: a randomized controlled trial. JAMA 6 Apixaban for Extended Treatment of Venous Thromboembolism. N Engl J Med 7 Drugs for treating giardiasis. Cochrane Database Syst Rev 8 Pentoxifylline for treating venous leg ulcers. Cochrane Database Syst Rev 9 Antibiotics for exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev 10 Psychological therapies for the management of chronic pain (excluding headache) in adults. Cochrane Database Syst Rev
Dear Prof. Peiyang: We thought you might enjoy reviewing the most interesting articles for the past month, based on the frequency with which subscribers viewed these in detail. The top 10 appear below. Brian Haynes MD, Editor, Evidence Updates # Article Title 1 Sequential versus triple therapy for the first-line treatment of Helicobacter pylori: a multicentre, open-label, randomised trial. Lancet 2 Initiation of allopurinol at first medical contact for acute attacks of gout: a randomized clinical trial. Am J Med 3 Reduction versus abrupt cessation in smokers who want to quit. Cochrane Database Syst Rev 4 Beta-blockers for hypertension. Cochrane Database Syst Rev 5 Scores to predict major bleeding risk during oral anticoagulation therapy: a prospective validation study. Am J Med 6 Horse chestnut seed extract for chronic venous insufficiency. Cochrane Database Syst Rev 7 Cognitive behavioural therapy as an adjunct to pharmacotherapy for primary care based patients with treatment resistant depression: results of the CoBalT randomised controlled trial. Lancet 8 Bloodstream infection, venous thrombosis, and peripherally inserted central catheters: reappraising the evidence. Am J Med 9 Vaccines for preventing rotavirus diarrhoea: vaccines in use. Cochrane Database Syst Rev 10 General health checks in adults for reducing morbidity and mortality from disease: Cochrane systematic review and meta-analysis. BMJ
Ross Stein is a geophysicist with the US Geological Survey in California, who studies how earthquakes interact by the transfer of stress. He wants everyone to be able to learn what their seismic risk is. The video is on Youtube: Defeating Earthquakes: Ross Stein
导读： 看，他们把他当人看。 看，他们把他当狗看。 他们把他当人看，他们是谁，他是谁？ 他们把他当狗看，他们是谁，他是谁？ http://www.whitehouse.gov/the-press-office/2012/11/22/weekly-address-wishing-american-people-happy-thanksgiving On behalf代表 of the Obama family家庭 – Michelle, Malia, Sasha and Bo – I want to wish everyone a very happy Thanksgiving. For us, like so many of you, this is a day full of family and friends; food （有没有FOODBALL)and football. It’s a day to fight the overwhelming urge to take a nap – at least until after dinner. But most of all, it’s a time to give thanks for each other（应该感谢谁？上帝，还是同类）, and for the incredible bounty we enjoy. That’s especially important this year. As a nation, we’ve just emerged from a campaign season that was passionate, noisy, and vital to our democracy. But it also required us to make choices – and sometimes those choices led us to focus on what sets us apart instead of what ties us together; on what candidate候选人 we support instead of what country we belong to.（美国也有党国问题） Thanksgiving is a chance to put it all in perspective – to remember that, despite our differences, we are, and always will be, Americans first and foremost. Today we give thanks for blessings that are all too rare in this world. The ability to spend time with the ones we love; to say what we want; to worship as we please; to know that there are brave men and women defending our freedom around the globe; and to look our children in the eye and tell them that, here in America, no dream is too big if they’re willing to work for it. We’re also grateful that this country has always been home to Americans who see these blessings not simply as gifts to enjoy, but as opportunities to give back. Americans who believe we have a responsibility to look out for those less fortunate – to pull each other up and move forward together. Right now, as we prepare to gather around our dinner tables, there are families in the northeast who don’t have that luxury. Many of them have lost everything to Hurricane Sandy – homes, possessions, even loved ones. And it will be a long time before life goes back to normal. But in the midst of so much tragedy, there are also glimmers of hope. Over the last few weeks, we’ve seen FEMA personnel, National Guard and first responders working around the clock in hard-hit communities. We’ve seen hospital workers using their lunch breaks to distribute supplies. Families offering up extra bedrooms. The fire department advertising free hot showers. Buses full of volunteers coming from hundreds of miles away. Neighbors sharing whatever they have – food, water, electricity – and saying again and again how lucky they are to have a roof over their heads. It would have been easy for these folks人民to do nothing – to worry about themselves and leave the rest to someone else. But that’s not who we are. That’s not what we do. As Americans, we are a bold, generous, big-hearted people. When our brothers and sisters are in need, we roll up our sleeves卷起袖子 and get to work – not for the recognition or the reward名和利, but because it’s the right thing to do. Because there but for the grace of God go I良心. And because here in America, we rise or fall荣辱与共 together, as one nation and one people. That’s something to be grateful for – today and every day. So to all the Americans doing your part to make our world a better place – it is my privilege荣幸 to serve担任 as your President. To all our servicemembers – it is my honor to be your Commander in Chief. And from our family to yours, happy Thanksgiving. http://en.wikipedia.org/wiki/Bo_(dog ) Bo Official White House portrait of the First Dog Other appellation(s) First Dog Charlie (by previous owner) Species Canis lupus familiaris Breed Portuguese Water Dog Sex Male Born Amigo's New Hope ( 2008-10-09 ) October 9, 2008 (age4) Nation from United States Knownfor Pet of the First Family of the United States Training Dawn Sylvia ( Hume, Virginia ) Can sit, present paw/shake, lie down, roll over, get off, wait Predecessor Barney Bush Owner Obama family Parents Dam : Penny (Amigo's Phor What Its Worth) ( Boyd, Texas ) Sire : Watson (Valkyrie's Dr. Watson Is Here) ( Ambridge, Pennsylvania ) Breeder: Julie Parker Appearance tuxedo/black and white Named after Obama girls ' cousins' pet cat and also Bo Diddley Bo (born October 9, 2008) is the pet dog of the Obama family, the First Family of the United States . Bo is a neutered male Portuguese Water Dog . President Barack Obama and his family were given the dog as a gift after months of speculation about the breed and identity of their future pet. The final choice was made in part because Malia Obama 's allergies dictated a need for a hypoallergenic breed. The White House has referred to him as the " First Dog ", a term occasionally used during recent U.S. administrations. Contents 1 Breed background 2 Breeding and original owners 3 Media attention as Obamas select the First Dog 4 Biographical details 5 Disputed rescue heritage 6 Reactions by and in the media 7 See also 8 References 9 External links Breed background Main article: Portuguese Water Dog The Portuguese Water Dog is a fairly rare breed; only 48 Portuguese Water Dogs were entered for Britain's Crufts competition in 2009 and the author of The New Complete Portuguese Water Dog, Kitty Braund, believes there are about 50,000 in North America. Due to its fleecy coat, the Portuguese Water Dog is considered a hypoallergenic dog breed . Breeding and original owners The Obamas with Bo Bred by Julie Parker of Erie County, Pennsylvania , Bo is the son of "Watson" (CH Valkyrie Dr. Watson is Here, Born 22.April.2002, AKC WS00562102) of the Rader family in the Pittsburgh suburb of Ambridge, Pennsylvania and of Penny who belongs to Art and Martha Stern of Boyd, Texas . One of Bo's nine litter mates is Senator Ted Kennedy 's Portie named Cappy (Amigo's Captain Courageous); the litter was named "Hope and Change" in honor of Obama's victory . Bo was purchased by a person unknown to the public, but eventually the new owner returned him to the Stern family; when buying the dog, the original purchaser had signed a contract requiring him to return the dog to the breeder if things did not work out. Bo was enrolled on January 5, 2009, with Kennedy's obedience trainer Dawn Sylvia-Stasiewicz , in Hume, Virginia . Bo has a brother named Rico, that is owned by a couple in Houston, Texas. Media attention as Obamas select the First Dog At his first press conference as President-elect , Obama was questioned by reporters as to which breed the family was looking to acquire; he replied, "Our preference would be to get a shelter dog, but, obviously, a lot of shelter dogs are mutts ." He also noted "Malia is allergic, so it has to be hypoallergenic. There are a number of breeds that are hypoallergenic." George Stephanopolous asked Obama on television in early January what kind of dog they would get, and when, saying that he was passing on a question from Obama's daughters who were sitting in the control room. Obama said, "They seem to have narrowed it down to a labradoodle or a Portuguese water hound ... medium-sized dog, and so, we're now going to start looking at shelters to see when one of those dogs might come up." Much was made by the public and press about the family's search for a dog. On April 12, 2009, it was announced that the Obamas would soon accept a six-month-old Portuguese Water Dog puppy as a gift from Senator Kennedy. The dog was reported to have visited the family some weeks earlier in a secret meeting to gauge compatibility and purportedly referred to by staffers as "The Meeting". However, the gift was not accepted until the dog officially arrived and moved in at the White House on Tuesday, April 14, 2009; Immediately after he arrived, the family staged a photo op with Bo on the property's South Lawn . At the conference, Obama was asked if he would allow Bo inside the Oval Office , to which he responded: "of course." He also gave a nod to President Harry Truman 's quote, "If you want a friend in Washington, get a dog." The White House website was later updated to include official pictures and biographical details of Bo. Biographical details Bo wearing a lei upon his White House arrival Listed by the name "Amigo's New Hope" with American Kennel Club 's breed registry and given the name "Charlie" by his original owners, the puppy received his current name from President Obama's two daughters, Malia and Sasha , in part after their cousins' cat and Michelle Obama 's father 's nickname Diddley; the dog is a namesake of deceased singer Bo Diddley . In June 2009, the White House released a baseball card for Bo with his new official portrait on one side and tongue-in-cheek statistics on the other; information included the facts that Bo's favorite food is tomatoes and that he does not yet know how to swim. The card is available by sending a self-addressed, stamped envelope to the White House. According to financial disclosure forms released by President Obama in 2010, Bo has a value of $1,600. In December 2010, Bo was permitted to accompany the Obama family to the guest house Plantation Estate in Hawaii. Hawaii, which is rabies-free, has strict quarantine rules of up to 120 days for dogs from outside the state. However, in accordance with rules modified in 2003, dogs are permitted if they have had two rabies shots (including one in the previous 90 days), pass a rabies blood test, and have a microchip implant . Disputed rescue heritage The Obamas walking with Bo The Obama family originally seemed to emphasize their desire for an adopted shelter dog, but made no firm commitments. In the summer of 2008, Best Friends Animal Society , an animal welfare organization, gathered 50,000 signatures on a petition asking the family to adopt a shelter animal. As Bo is a gift from the Kennedy family, he is not a shelter dog. Some dog experts, such as Cesar Millan , state that Bo could be considered part of a larger group known as rescue dogs, as he was unsuccessful in his first home, when plans for him to provide companionship to an older female dog went awry because he irritated the dog through attempts to suckle . The Obamas have pledged to donate to the District of Columbia Humane Society to show their support for shelter dogs. Some criticism has arisen from animal welfare supporters because Bo was not adopted from a shelter. The Humane Society of the United States released a statement on their website thanking the Obamas "for taking in a second-chance dog," but also encouraged the public to avoid going through breeders. Reactions by and in the media Bo and President Obama running through the east wing of the White House The Washington Post ’s Manuel Roig-Franzia, granted exclusive initial access to Bo for the print media, described the puppy: "Bo's a handsome little guy. Well suited for formal occasions at the White House, he's got tuxedo-black fur, with a white chest, white paws and a rakish white goatee." People for the Ethical Treatment of Animals (PETA) described the family's choice to accept the gift of a puppy from a family friend as "disquieting" and publicly urged the President to have Bo neutered, though the dog had been neutered before the Obamas received him. Bo in March 2010 In anticipation of increased interest in the breed , the Portuguese Water Dog Club of America issued a statement requesting that members of the public considering obtaining the dogs "ensure that this breed fits their lifestyle," advising that Porties' needs preclude their being left alone for long periods or boarded in kennels . Immediately upon Bo joining the First Family, four children's books and a plush toy depicting him were slated for publication or manufacture. On July 17, 2009, the author Ben Greenman , writing in The New York Times as Bo, reflected on his first hundred days in office. In the final episode of the History Channel 's Life After People , aired March 16, 2010, the producers imagined what life would be like for Bo after the disappearance of humanity. This showed that he would leave the White House, and live off seafood from the Chesapeake Bay. Bo was also shown on Dogs 101 . Bo has appeared in the comic book Lockjaw and the Pet Avengers and on the TV show Late Night with Jimmy Fallon . See also United States presidential pets References ^ a b Dave, By (2009-04-20). "Vigilant press spots Bo, the first dog, out for a walk | csmonitor.com" . The Christian Science Monitor . http://features.csmonitor.com/politics/2009/04/20/vigilant-press-spots-bo-the-first-dog-out-for-a-walk/ . Retrieved 2009-04-26 . ^ a b c d e "The White House – Blog Post – Meet Bo, the First Dog" . Whitehouse.gov . http://www.whitehouse.gov/blog/09/04/12/Meet-Bo-the-First-Dog/ . Retrieved 2009-08-10 . ^ a b Cooper, Helen (April 12, 2009). "One Obama Search Ends With a Puppy Named Bo" . The New York Times . http://www.nytimes.com/2009/04/13/us/politics/13obama.html . Retrieved April 18, 2009 . "Other Web sites, which have been tracking the saga of the selection of the first dog, were in a frenzy over the weekend." ^ Silva, Mark (2009-04-12). "Obamas' dog Bo:'Amigo's New Hope'" . Swamppolitics.com . http://www.swamppolitics.com/news/politics/blog/2009/04/obamas_dog_bo_amigos_new_hope.html . Retrieved 2009-10-19 . ^ "Obama Dog Trainer: Bo Already "Sits, Shakes, Rolls Over"" . Us Weekly. 2009-04-15 . http://www.usmagazine.com/news/obama-trainer-bo-already-sits-shakes-rolls-over-2009144 . Retrieved 2009-04-26 . ^ "The Obama Dog Blog: Cappy's Breeder Rejects Obama Dog Connection" . Dreamdogsart.typepad.com. 2009-04-15 . http://dreamdogsart.typepad.com/the_obamas_dog/2009/04/cappys-breeder-rejects-obama-dog-connection.html . Retrieved 2009-04-26 . ^ a b Sostek, Anya (April 14, 2009). "First dog's father from Ambridge" . Pittsburgh Post-Gazette . http://www.post-gazette.com/pg/09104/962604-57.stm . Retrieved 2011-06-11 . ^ a b Hess, Amanda (2009-04-13). "PETA Encourages Obamas to Neuter Neutered Dog" . nbcwashington.com . http://www.nbcwashington.com/news/local/PETA_Encourages_Obamas_to_Neuter_Neutered_Dog.html . Retrieved 2009-04-15 . ^ "World | Obama family 'picks first puppy'" . BBC News. 2009-04-12 . http://news.bbc.co.uk/1/hi/world/americas/7995570.stm . Retrieved 2009-04-26 . ^ "PORTUGUESE WATER DOG" . Crufts . 2009 . http://crufts.fossedata.co.uk/Breed.asp?ShowYear=2009GroupID=WORScheduleID=160 . Retrieved 2009-04-17 . ^ Ryan, Denise (2009-04-15). "U.S. first family puts Portuguese water dog on the map" . .canada.com . http://www2.canada.com/vancouversun/news/westcoastnews/story.html?id=eb38a8c3-9ef9-40c2-bda1-3d87c1a6d9adk=17132p=2 . Retrieved 2009-04-26 . ^ Berkowitz, Lana. "Houston pooch has friend in high place" . Houston Chronicle . http://www.chron.com/disp/story.mpl/pets/6372225.html . Retrieved 2009-10-13 . ^ a b Rhee, Foon (2008-11-10). "Chewing over Obama's 'mutt' reference – 2008 Presidential Campaign Blog – Political Intelligence" . Boston Globe . http://www.boston.com/news/politics/politicalintelligence/2008/11/chewing_over_ob.html . Retrieved 2009-04-26 . ^ Weiner, Rachel (2009-01-13). "Obama: Finding Puppy "Tougher Than Finding A Commerce Secretary" (VIDEO)" . Huffington Post . http://www.huffingtonpost.com/2009/01/11/obama-finding-puppy-tough_n_156914.html . Retrieved 2009-04-26 . ^ Roig-Franzia, Manuel (2009-04-12). "The First Puppy Makes a Big Splash" . The Washington Post . http://www.washingtonpost.com/wp-dyn/content/article/2009/04/11/AR2009041102484_2.html?sid=ST2009041202878 . Retrieved 2009-04-26 . ^ a b Theimer, Sharon. "PROMISES, PROMISES: Is Obama dog a rescue or not?" . Associated Press . http://www.breitbart.com/article.php?id=D97HQQP00show_article=1 . Retrieved 2009-04-26 . ^ a b c Theimer, Sharon. "First dog Bo makes himself at home" . The Washington Times . http://www.washingtontimes.com/news/2009/apr/15/first-dog-bo-takes-obamas-for-romp-as-he-sniffs-ou/ . Retrieved 2009-04-26 . ^ Saul, Michael (2009-04-12). "First photos of First Dog: Obamas meet Bo, their new Portuguese Water Dog" . Daily News (New York) . http://www.nydailynews.com/news/politics/2009/04/11/2009-04-11_its_easter_puppy_for_obamas_first_family_getting_portuguese_water_dog_puppy__rep.html . Retrieved 2009-04-13 . ^ St. Clair, Stacy (2009-04-13). "Obamas' dog: Meet Bo, the Portuguese water dog" . Chicago Tribune . http://www.chicagotribune.com/news/chi-talk-obama-puppy-13-apr13,0,2536424.story . Retrieved 2009-04-13 . ^ "The First Puppy Makes a Big Splash" . PopWatch Blog . 2009-04-12 . http://popwatch.ew.com/popwatch/2009/04/barack-obama-do.html . Retrieved 2009-10-19 . ^ Sobieraj-Westfall, Sandra (April 12, 2009). "The Obamas' Dog Has Arrived – at Last!" . People . http://www.people.com/people/article/0,,20271921,00.html . Retrieved October 2, 2010 . ^ Iovino, Jim. "First Dog Bo's Portrait Out as Baseball Card" . NBC Washington . http://www.nbcwashington.com/around_town/the_scene/Bos-Rookie-Card-Sure-to-be-Collectors-Item.html . Retrieved 2009-08-10 . ^ Lee, Jess. "The White House – Blog Post – Bo: The Portrait, the Baseball Card" . Whitehouse.gov . http://www.whitehouse.gov/blog/Bo-The-Portrait-the-Baseball-Card/ . Retrieved 2009-08-10 . ^ Conolly, Katie. "The Gaggle: Official Portrait of First Dog Bo Released" . Newsweek . http://blog.newsweek.com/blogs/thegaggle/archive/2009/06/19/official-portrait-of-first-dog-bo-released.aspx . Retrieved 2009-08-10 . ^ Marr, Kendra (May 17, 2010). "Hot dog: $1,600 Bo listed on disclosure forms" . The Politico . http://www.politico.com/politico44/perm/0510/hot_dog_2a94d94b-62d5-46e8-84c1-da3cae477d9e.html . Retrieved 18 May 2010 . ^ "Uncategorized Bo Obama Faced Possible Quarantine in Hawaii, Asked to Produce Papers" . NwoDaily.com. 2010-12-21 . http://nwodaily.com/2010/12/bo-obama-faced-possible-quarantine-in-hawaii-asked-to-produce-papers/ . Retrieved 2011-06-16 . ^ "Animal Quarantine Information – Hawaii Department of Agriculture" . Hawaii.gov . http://hawaii.gov/hdoa/ai/aqs/info . Retrieved 2011-06-16 . ^ Greene, Nick (2009-04-15). "Obamas criticised for breaking promise of adopting dog from shelter" . London: The Daily Telegraph . http://www.telegraph.co.uk/news/worldnews/northamerica/usa/barackobama/5154973/Obamas-criticised-for-breaking-promise-of-adopting-dog-from-shelter.html . Retrieved 2009-04-26 . ^ a b Goldston, Linda (2008-11-05). "Obama family will adopt, rather than buy, a dog" . Current.com . http://current.com/items/89502136_obama-family-will-adopt-rather-than-buy-a-dog.htm . Retrieved 2009-10-19 . ^ Vinzant, Carol (2009-04-16). "5 Things You Don't Know About First Dog Bo – Barack Obama" . People . http://www.people.com/people/article/0,,20272856,00.html?xid=rss-topheadlines . Retrieved 2009-04-26 . ^ "Obama puppy: Portuguese water dog Bo is Obama puppy" . The Baltimore Sun. 2009-04-13 . http://www.baltimoresun.com/news/nation/bal-te.dog13apr13,0,304629.story . Retrieved 2009-04-26 . ^ "The HSUS Congratulates First Family on New White House Dog" . Humane Society of the United States. 2009-04-12 . http://www.humanesociety.org/news/press_releases/2009/04/first_family_dog_sm_041209.html . Retrieved 2012-11-05 . ^ "Obama Dog Bo Diddley Obama Puppy First Dog Photos Video at The Insider" . Theinsider.com . http://www.theinsider.com/news/2003457_Obama_Dog_Bo_Diddley_Obama_Puppy_First_Dog_Photos_Video . Retrieved 2009-08-10 . ^ Bedard, Paul (2009-04-13). "PETA urges Obama to snip Bo the first dog" . USNews.com . http://www.usnews.com/blogs/washington-whispers/2009/4/13/peta-urges-obama-to-snip-bo-the-first-dog.html . Retrieved 2009-10-19 . ^ "Obama Family’s Choice for "First Dog" Prompts PWDCA to Remind Public About Responsible Breeding and Dog Ownership" . The Portuguese Water Dog Club of America, Inc. 2009-04-13 . http://www.akc.org/poll/special/PWDCARelease.pdf . Retrieved 2009-10-19 . ^ Irvine, Chris (2009-04-16). "Bo Obama to star in children's book" . London: The Daily Telegraph . http://www.telegraph.co.uk/news/worldnews/northamerica/usa/barackobama/5167659/Bo-Obama-to-star-in-childrens-book.html . Retrieved 2009-04-26 . ^ Kondo, Koji (April 2009). Bo Obama: First Dog of the United States of America . CreateSpace. ISBN 1-4421-5644-9 . ^ Lewis, J. Patrick; Beth Zappitello, Tim Bowers (April 2009). First Dog . Sleeping Bear Press. ISBN 1-58536-467-3 . ^ Greenman, Ben (2009-07-16). "The First Hundred (Dog) Days" . The New York Times . http://www.nytimes.com/2009/07/17/opinion/17greenman.html . Retrieved 2009-10-19 . ^ "Take Me To Your Leader" . History . http://www.history.com/shows/life-after-people/episodes/ . Retrieved 2010-03-25 . "The President's dog must learn the ways of the wild." ^ Bo Obama's anniversary: First year as First Dog , The Washington Post, April 15, 2010 ^ Dogs 101 Ep. 10, All the Presidents' Pets , ^ Dogs 101 ep. 14, Bernese Mountain Dog, Afghan, Portuguese Water Dog, Cairn Terrier, Alaskan Malamute http://en.wikipedia.org/wiki/United_States_presidential_pets History of White House dogs In 1944 Franklin D. Roosevelt was running for his fourth term when rumors surfaced that his Scottish Terrier , Fala , had accidentally been left behind when visiting the Aleutian Islands . After allegedly sending back ships to rescue his dog, Roosevelt was ridiculed and accused of spending thousands of taxpayers’ dollars to retrieve his dog. At a speech following this Roosevelt said, "you can criticize me, my wife and my family, but you can't criticize my little dog. He's Scotch and all these allegations about spending all this money have just made his little soul furious." What was later called the ‘ Fala Speech ’ reportedly turned the election around for Roosevelt.
Dear Prof. Peiyang: We thought you might enjoy reviewing the most interesting articles for the past month, based on the frequency with which subscribers viewed these in detail. The top 10 appear below. Brian Haynes MD, Editor, Evidence Updates # Article Title 1 Low sodium versus normal sodium diets in systolic heart failure: systematic review and meta-analysis. Heart 2 Corticosteroids as standalone or add-on treatment for sore throat. Cochrane Database Syst Rev 3 Efficacy and safety of the novel oral anticoagulants in atrial fibrillation: a systematic review and meta-analysis of the literature. Circulation 4 Oestrogen therapy for urinary incontinence in post-menopausal women. Cochrane Database Syst Rev 5 Low-Dose Aspirin for Preventing Recurrent Venous Thromboembolism. N Engl J Med 6 Efficacy of antibiotic therapy for acute exacerbations of mild to moderate chronic obstructive pulmonary disease. Am J Respir Crit Care Med 7 Comparative effectiveness and safety of methods of insulin delivery and glucose monitoring for diabetes mellitus: a systematic review and meta-analysis. Ann Intern Med 8 Incentives for preventing smoking in children and adolescents. Cochrane Database Syst Rev 9 Antibiotics for clinically diagnosed acute rhinosinusitis in adults. Cochrane Database Syst Rev 10 Exenatide once weekly versus liraglutide once daily in patients with type 2 diabetes (DURATION-6): a randomised, open-label study. Lancet
1 Effect of hormone replacement therapy on cardiovascular events in recently postmenopausal women: randomised trial. BMJ 2 Magnesium for skeletal muscle cramps. Cochrane Database Syst Rev 3 Fever control using external cooling in septic shock: a randomized controlled trial. Am J Respir Crit Care Med 4 Cholinesterase inhibitors for mild cognitive impairment. Cochrane Database Syst Rev 5 Screening for type 2 diabetes and population mortality over 10 years (ADDITION-Cambridge): a cluster-randomised controlled trial. Lancet 6 Antibiotics versus placebo for acute bacterial conjunctivitis. Cochrane Database Syst Rev 7 Long-term cardiovascular risk of nonsteroidal anti-inflammatory drug use according to time passed after first-time myocardial infarction: a nationwide cohort study. Circulation 8 The CHA2DS2-VASc score identifies those patients with atrial fibrillation and a CHADS2 score of 1 who are unlikely to benefit from oral anticoagulant therapy. Eur Heart J 9 Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections. Cochrane Database Syst Rev 10 Hypothermia for neuroprotection in adults after cardiopulmonary resuscitation. Cochrane Database Syst Rev
Dear Prof. Peiyang: We thought you might enjoy reviewing the most interesting articles for the past month, based on the frequency with which subscribers viewed these in detail. The top 10 appear below. Brian Haynes MD, Editor, Evidence Updates 1 Does this adult patient with suspected bacteremia require blood cultures?. JAMA 2 Coronary CT angiography versus standard evaluation in acute chest pain. N Engl J Med 3 Intensive and Standard Blood Pressure Targets in Patients With Type 2 Diabetes Mellitus: Systematic Review and Meta-analysis. Arch Intern Med 4 Pharmacotherapy for mild hypertension. Cochrane Database Syst Rev 5 Randomized clinical trial of antibiotics in acute uncomplicated diverticulitis. Br J Surg 6 Long term hormone therapy for perimenopausal and postmenopausal women. Cochrane Database Syst Rev 7 Immunochemical Fecal Occult Blood Testing Is Equally Sensitive for Proximal and Distal Advanced Neoplasia. Am J Gastroenterol 8 Restenosis after carotid artery stenting and endarterectomy: a secondary analysis of CREST, a randomised controlled trial. Lancet Neurol 9 Capsule Endoscopy or Angiography in Patients With Acute Overt Obscure Gastrointestinal Bleeding: A Prospective Randomized Study With Long-Term Follow-Up. Am J Gastroenterol 10 Intravenous immunoglobulin for Guillain-Barre syndrome. Cochrane Database Syst Rev
1 Aspirin for preventing the recurrence of venous thromboembolism. N Engl J Med 2 Dual or mono antiplatelet therapy for patients with acute ischemic stroke or transient ischemic attack: systematic review and meta-analysis of randomized controlled trials. Stroke 3 Menopausal Hormone Therapy for the Primary Prevention of Chronic Conditions: A Systematic Review to Update the U.S. Preventive Services Task Force Recommendations. Ann Intern Med 4 The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial ): a randomised controlled trial. Lancet 5 Apixaban versus aspirin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a predefined subgroup analysis from AVERROES, a randomised trial. Lancet Neurol 6 Meta-Analysis of Randomized Trials of Angioedema as an Adverse Event of Renin-Angiotensin System Inhibitors. Am J Cardiol 7 Systematic review of the cost-effectiveness of varenicline vs. bupropion for smoking cessation. Int J Clin Pract 8 Efficacy and safety of exenatide once weekly versus metformin, pioglitazone, and sitagliptin used as monotherapy in drug-naive patients with type 2 diabetes (DURATION-4): a 26-week double-blind study. Diabetes Care 9 Rapid viral diagnosis for acute febrile respiratory illness in children in the Emergency Department. Cochrane Database Syst Rev 10 The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials. Lancet
# Article Title 1 Meta-Analysis of Efficacy and Safety of New Oral Anticoagulants (Dabigatran, Rivaroxaban, Apixaban) Versus Warfarin in Patients With Atrial Fibrillation. Am J Cardiol 2 Warfarin and aspirin in patients with heart failure and sinus rhythm. N Engl J Med 3 Angiotensin receptor blockers for heart failure. Cochrane Database Syst Rev 4 Risk of Clostridium difficile Infection With Acid Suppressing Drugs and Antibiotics: Meta-Analysis. Am J Gastroenterol 5 Risk of cardiovascular serious adverse events associated with varenicline use for tobacco cessation: systematic review and meta-analysis. BMJ 6 The usefulness of HbA1c in postpartum reclassification of gestational diabetes. BJOG 7 Dopamine versus norepinephrine in the treatment of septic shock: a meta-analysis*. Crit Care Med 8 Venous thrombosis in users of non-oral hormonal contraception: follow-up study, Denmark 2001-10. BMJ 9 Nicotine receptor partial agonists for smoking cessation. Cochrane Database Syst Rev 10 Long-acting beta(2)-agonist in addition to tiotropium versus either tiotropium or long-acting beta(2)-agonist alone for chronic obstructive pulmonary disease. Cochrane Database Syst Rev
1 Treatment of mild to moderate sinusitis. Arch Intern Med 2 Efficacy of Omega-3 Fatty Acid Supplements (Eicosapentaenoic Acid and Docosahexaenoic Acid) in the Secondary Prevention of Cardiovascular Disease: A Meta-analysis of Randomized, Double-blind, Placebo-Controlled Trials. Arch Intern Med 3 Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials. Lancet 4 Oral rivaroxaban for the treatment of symptomatic pulmonary embolism. N Engl J Med 5 Association of treatment with losartan vs candesartan and mortality among patients with heart failure. JAMA 6 Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials. Lancet 7 Bariatric surgery versus intensive medical therapy in obese patients with diabetes. N Engl J Med 8 Bariatric surgery versus conventional medical therapy for type 2 diabetes. N Engl J Med 9 Safety and efficacy of antibiotics compared with appendicectomy for treatment of uncomplicated acute appendicitis: meta-analysis of randomised controlled trials. BMJ 10 Oxygen therapy for pneumonia in adults. Cochrane Database Syst Rev
Dear Prof. Peiyang: We thought you might enjoy reviewing the most interesting articles for the past month, based on the frequency with which subscribers viewed these in detail. The top 10 appear below. Brian Haynes MD, Editor, Evidence Updates 1 Dabigatran Association With Higher Risk of Acute Coronary Events: Meta-analysis of Noninferiority Randomized Controlled Trials. Arch Intern Med 2 Effect of Perioperative Statins on Death, Myocardial Infarction, Atrial Fibrillation, and Length of Stay: A Systematic Review and Meta-analysis. Arch Surg 3 Water for wound cleansing. Cochrane Database Syst Rev 4 Donepezil and memantine for moderate-to-severe Alzheimer`s disease. N Engl J Med 5 Hypnotics' association with mortality or cancer: a matched cohort study. BMJ Open 6 Risk of mortality among individual antipsychotics in patients with dementia. Am J Psychiatry 7 Lithium toxicity profile: a systematic review and meta-analysis. Lancet 8 Randomized clinical trial for apogeotropic horizontal canal benign paroxysmal positional vertigo. Neurology 9 Lacosamide for neuropathic pain and fibromyalgia in adults. Cochrane Database Syst Rev 10 Accuracy of Rapid Influenza Diagnostic Tests: A Meta-analysis. Ann Intern Med
Lab members: Over the past several months, it has become clear to me that if there is no drastic change in the lab, Poo lab will soon cease to be a productive, first-rate lab that you chose to join in the first place. Lab progress reports over the past six months have clearly shown the lack of progress in most projects.one year ago, when we first moved to Berkeley, I expressed clearly to everyone my expectation from eachone in the lab. The most important thing is what I consider to be sufficient amount of time and effort in the lab work. I mentioned that about 60 hr working time per week is what I consider the minimal time an average successful young scientist in these days has to put into the lab work. There may be a few rare lucky fellows like Florian, who had two Nature papers in his sleeve already, can enjoy life for a while and still get a job offer from Harvard. noone else in the lab has Florian's luxury to play around. Thus I am imposing strict rules in the lab from now on: 1. Everyone works at least 50 hr a week in the lab （e.g., 8+ hr a day, six days a week）. This is by far lower than what I am doing every day and throughout most of my career.You may be smarter or do not want to be ssuccessful, but I am not asking you to match my time in the lab. 2. By working, I mean real bench work. This does not include surfing on the computer and sending and receiving e-mails for non-scientific matters unrelated to your work （you can do this after work in the lab or at home, and excessive chatting on nonscientific matters. No long lunch break except special occasions. I suggest that everyone puts in at least 6 hr concentrated bench work and 2+ hr reading and other research-related activity each day. Reading papers and books should be done mostly after work.More time can be spent on reading, literature search and writing during working hours when you are ready for writing a paper. 3. I must be inxxxxed in person by e-mail （even in my absence from the lab）when you are absent from the lab for a whole day or more. Inxxxx me early your vacation plan. Taking more than 20 working days out ofone year is the maximum to me. In fact, none of you are reporting any vacation and sick leave on your time sheet （against the university rule, although I have been signing the sheets））, but you know roughly how many days you were not here. On the whole, I understand and accept the fact that you may not fulfill the above requirements all the time, due to health reasons, occasional personal business. But if you do not like to follow the rules because it is simply a matter of choice of life style, I respect your choice but suggest you start making plans immediately and leave the lab by the end of January 31. I will do my best to help you to locate a lab to transfer or to find a job. If you do accept the conditions I describe above, I am happy to continue to provide my best support to your work, hopefully more than I have done in the past. I will review the progress of everyone in the lab by the end of June of 2002. I expect everyone to have made sufficient progress in the research so that a good paper is in sight （at least to the level of J.Neuroscience. If you cannot meet this goal at that time, I will have to ask you to prepare to leave my lab by the end of August.） By Mu-ming －As a scientist, you must dedicate everything to this business 作为一个科学家，你必须把一切都献身给科研事业. － Working time: 8-hour is unpractical. There is NO way for a scientist or a Ph.D student to workonly 8 hours a day! 每天仅仅工作8个小时是不行的。对于一个 博士 或者科学家，每天仅仅工作8个小时根本根本就是死路一条！（“NO way”） － Go to your mother’s house for afternoon naps and never come back! 如果有人敢午休，那就马上卷铺盖走人，永远不要再回实验室！ － Vacation: 5 weeks per year (Chinese New Year, the May Day and the National Day breaks are included) 包括春节，五一，国庆，每年全部假期一共5个星期。 － Start your morning work not later than 8:30 am and afternoon work no later than 1 pm 上午必须早于8：30上班，下午早于1点上班。（注意，没有规定几点下班。） － Surf over the Internet for non-scientific purposes should be less than 30 min a day 每天用于看网页以及其他与科研无关事情的时间不得多余30分钟。 － Reading newspapers should be limited less than 30 min a day 每天看报纸的时间不得多余30分钟 － Novels or other non-scientific journals/magazines are not permitted in the lab and office 小说和非科研性杂志不准带入实验室 － If you are absent from the lab more thanone hour, get permission first. 如果离开实验室超过1个小时，必须事先请假并得到允许。 － Everyone has personal business, but the lab business always has priority unless in emergency 除非紧急的事情，否则实验室的事情永远大于私事。 － In this business, an “average” student who works seven days a week is definitely more productive than a “genius” who works five days a week 在这行里，每周只工作5天，即使是天才，也比要低于比一个工作7天的资质平平的人还要差。 － If you are able to make any major progresses by working 8 hours a day and 5 days a week, every fortunate in this world must be on your side! 如果你即使每天工作8个小时并且每周只工作5天，居然也能成功哪怕只有一次（any）。那除非你是上帝（主宰了世界上一切的人）！
arise! people who don't want to be slave. Use the body to build a new great wall! When chinese come to the dangeous situation, everyone shout in anger! Arise! Arise! Arise! Step forward under enemy's gun! GO! GO! GO! SO funny。。。
Dear Prof. Peiyang: We thought you might enjoy reviewing the most interesting articles for the past month, based on the frequency with which subscribers viewed these in detail. The top 10 appear below. Brian Haynes MD, Editor, Evidence Updates # Article Title 1 Effect of Metformin on mortality in patients with heart failure and type 2 diabetes mellitus. Am J Cardiol 2 Chest-compression-only versus standard cardiopulmonary resuscitation: a meta-analysis. Lancet 3 Intensive lowering of LDL cholesterol with 80 mg versus 20 mg simvastatin daily in 12 064 survivors of myocardial infarction: a double-blind randomised trial. Lancet 4 Sulphonylurea-metformin combination therapy, cardiovascular disease and all-cause mortality: the Fremantle Diabetes Study. Diabetes Obes Metab 5 Clopidogrel with or without Omeprazole in Coronary Artery Disease. N Engl J Med 6 Tiotropium bromide step-up therapy for adults with uncontrolled asthma. N Engl J Med 7 Four-year follow-up of surgical versus non-surgical therapy for chronic low back pain. Ann Rheum Dis 8 Pharmacologic-based strategies for smoking cessation: clinical and cost-effectiveness analyses.. Canadian Agency for Drugs and Technologies in Health (CADTH) 9 Estrogen plus progestin and breast cancer incidence and mortality in postmenopausal women. JAMA 10 Is thrombolysis safe in the elderly?: analysis of a national database. Stroke
Dear Prof. Peiyang: We thought you might enjoy reviewing the most interesting articles for the past month, based on the frequency with which subscribers viewed these in detail. The top 10 appear below. Brian Haynes MD, Editor, Evidence Updates This month's most accessed articles. # Article Title 1 Acute and preventive pharmacologic treatment of cluster headache. Neurology 2 Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network meta-analysis. BMJ 3 Subclinical hypothyroidism and the risk of coronary heart disease and mortality. JAMA 4 Vitamin D in adult health and disease: a review and guideline statement from Osteoporosis Canada. CMAJ 5 Linezolid versus vancomycin or teicoplanin for nosocomial pneumonia: a systematic review and meta-analysis. Crit Care Med 6 Effect of home testing of international normalized ratio on clinical events. N Engl J Med 7 Tests used to evaluate dizziness in primary care. CMAJ 8 Effects of Lowering Homocysteine Levels With B Vitamins on Cardiovascular Disease, Cancer, and Cause-Specific Mortality: Meta-analysis of 8 Randomized Trials Involving 37 485 Individuals. Arch Intern Med 9 Managing medications in clinically complex elders: ``There`s got to be a happy medium``. JAMA 10 Proton-pump inhibitors are associated with increased cardiovascular risk independent of clopidogrel use: a nationwide cohort study. Ann Intern Med
Dear Prof. Peiyang: We thought you might enjoy reviewing the most interesting articles for the past month, based on the frequency with which subscribers viewed these in detail. The top 10 appear below. Brian Haynes MD, Editor, Evidence Updates # Article Title 1 Aspirin with or without an antiemetic for acute migraine headaches in adults. Cochrane Database Syst Rev 2 Adjunctive dexamethasone in bacterial meningitis: a meta-analysis of individual patient data. Lancet Neurol 3 Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. JAMA 4 Efficacy of acupuncture in fibromyalgia syndrome--a systematic review with a meta-analysis of controlled clinical trials. Rheumatology (Oxford) 5 Nut consumption and blood lipid levels: a pooled analysis of 25 intervention trials. Arch Intern Med 6 Diagnostic accuracy and clinical utility of noninvasive testing for coronary artery disease. Ann Intern Med 7 Pregabalin in fibromyalgia: meta-analysis of efficacy and safety from company clinical trial reports. Rheumatology (Oxford) 8 Meta-analysis: Noninvasive ventilation in acute cardiogenic pulmonary edema. Ann Intern Med 9 Proton pump inhibitors and risk for recurrent Clostridium difficile infection. Arch Intern Med 10 Effect of prior intensive insulin treatment during the Diabetes Control and Complications Trial (DCCT) on peripheral neuropathy in type 1 diabetes during the Epidemiology of Diabetes Interventions and Complications (EDIC) Study. Diabetes Care
Dear Prof. Peiyang: We thought you might enjoy reviewing the most interesting articles for the past month, based on the frequency with which subscribers viewed these in detail. The top 10 appear below. Brian Haynes MD, Editor, Evidence Updates # Article Title 1 Mucolytic agents for chronic bronchitis or chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2 Fibrate/Statin initiation in warfarin users and gastrointestinal bleeding risk. Am J Med 3 Clinical pathways: effects on professional practice, patient outcomes, length of stay and hospital costs. Cochrane Database Syst Rev 4 Renal outcomes with different fixed-dose combination therapies in patients with hypertension at high risk for cardiovascular events (ACCOMPLISH): a prespecified secondary analysis of a randomised controlled trial. Lancet 5 Risk of miscarriage with bivalent vaccine against human papillomavirus (HPV) types 16 and 18: pooled analysis of two randomised controlled trials. BMJ 6 Fluvoxamine versus other anti-depressive agents for depression. Cochrane Database Syst Rev 7 Randomised controlled trial of integrated care to reduce disability from chronic low back pain in working and private life. BMJ 8 Idiopathic superficial thrombophlebitis and the incidence of cancer in primary care patients. Ann Fam Med 9 Efficacy and safety of monotherapy of sitagliptin compared with metformin in patients with type 2 diabetes. Diabetes Obes Metab 10 Will this patient develop persistent disabling low back pain? JAMA
Dear Prof. Peiyang: We thought you might enjoy reviewing the most interesting articles for the past month, based on the frequency with which subscribers viewed these in detail. The top 10 appear below. Brian Haynes MD, Editor, Evidence Updates # Article Title 1 Antibiotics in addition to systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2 Sequential therapy or triple therapy for Helicobacter pylori infection: systematic review and meta-analysis of randomized controlled trials in adults and children. Am J Gastroenterol 3 Rosuvastatin in the prevention of stroke among men and women with elevated levels of C-reactive protein: justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER). Circulation 4 The clinical effectiveness of glucosamine and chondroitin supplements in slowing or arresting progression of osteoarthritis of the knee: a systematic review and economic evaluation. Health Technol Assess 5 Comparison of A1C and fasting glucose criteria to diagnose diabetes among U.S. adults. Diabetes Care 6 Duration and magnitude of the postoperative risk of venous thromboembolism in middle aged women: prospective cohort study. BMJ 7 Antidepressant drug effects and depression severity: a patient-level meta-analysis. JAMA 8 Risk of cardiovascular disease and all cause mortality among patients with type 2 diabetes prescribed oral antidiabetes drugs: retrospective cohort study using UK general practice research database. BMJ 9 Smoking, smoking cessation, and risk for type 2 diabetes mellitus: a cohort study. Ann Intern Med 10 The Enhancing Secondary Prevention in Coronary Artery Disease trial. CMAJ
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