(参会的海内外中国人合影留念) 上午: Corrosion Session K2: Mechanicalintegrity of magnesium-based biodegradable alloys under combined action ofstress and corrosive body fluid Singh Raman, RK Departmentof Mechanical and Aerospace Engineering, Department of Chemical Engineering,Monash University (Melbourne), VIC 3800, Australia Whyare Mg alloy suspectible to SCC? (1)Film disruption –rapiddissolution—repassivation (20Hydrogenaccumulation and embrittlement ahead of crack-tip CouldTWINNING accelerate SCC of Mg alloys? SCCsusceptibility indices Notchedspecimens need to be tested for reliable SCC data. Circumferentialnotched tensile testing of Az91D AB 8(2012) Al-freeMg alloys: ZX50, WZ21, WE43 Thecommon mode of SCC crack propagation is transangular Thereis great needs of developing SCC and CF data for Mg alloys for biomedicalapplications O8. Bending strengthand crack propagation in cast Mg10Gd influenced by corrosion Maier P, Mendis CL,Tober G, Briesemeister J, Minciel E, Hort N Universityof Applied Sciences Stralsund, Stralsund, Germany Mg-10Gd Prebendingplates: contour to fit the bone surface, straight plate to curves bone Samples110X20X4mm Span=90mm 1mm/min Bendingincrease strength(stability) Bendingdecreases fracture toughness, so “cold working” should be avoided. O9. Effects of grainsize on the corrosion resistance of Mg-Zn-Ca Alloy Liu D, Liu L, Liu Y,Song R, Chen M Schoolof Materials Science and Engineering, Tianjin University of Technology, Tianjin300384, China Corrosionscience 52(2010) 589-594 Copperwedge shape mould to reach different grain size Theaddition of Ca-P ceramic can act as grain refiner. Further ECAP will furtherimprove the corrosion resistance. O10. Biodegradationbehaviour of magnesium alloy under flow-induced shear stress Wang J, Shanov V, XuZG, Jang Y, Giri V, Collins B, Sankar J, Huang N, Yun Y EngineeringResearch Center for Revolutionizing Metallic Biomaterials, North Carolina A T State University, NC, USA Computationalanalysis on Flow-induced shear stress Mg-5Zn-0.3Ca,AZ31 Insitu and real-time electrochemical monitoring of the corrosion under FISS O11. Investigation ofcoated magnesium alloys by IR, Raman, X-ray and Mass spectrometry Vano-Herrera K,Zimmermann F, Stekker M, Vogt C LeibnizUniversity Hannover, Institute for Inorganic Chemistry, Germany Degradationof protective layers polymers on stent Micro-Raman Sensitivity(smallspots for high x-y resolution) Correctionmethods for instrument parameters Matrix-matchedcalibration Methods: Jointmelting of both polymers Dryingof solution Micro-XRFfor degradation products ex vivo 40KV image size 4.7X3.6mm Resolution10 micrometer Micro-PIXEdetect on biodegradation products 2.25MeVprotons Resolution1 micrometer, NdL, coronary artery, 4 weeks Surveyscan Histomorphologicalanalysis? 用 PIXE 分析支架的切片,利用元素谱像,更精确测定支架内的内膜厚度,比 histology 。 还可以测量 Degree of calcification LADand LCx Needlein a haystack Whybackground values are important? Letassume to put 1 g Mg implant in a 1 Kg rat 1g/Kg Letassume the alloy contains 10% of an alloying elements 0.1g/Kg(100ppm) Muchmore realistic 1mg og Mg implant in a kg rat 1mg/kgand o.1mg/kg (100ppb) Analyticalchallenges Valuesessential to determine enrichment processes in organs and tissue afterimplantation of alloys Valuesin biological samples from ppm (ug/g) to sub-pppb (fg/g) levels Severalanalyitical techniguqes ICP-OES,ICP-MAS clean room conditions Complexcleaning routine of vials and tools required (sub-boiled acids, ultra-purewater, special materials for vials) SOP17. Electrochemicaldetection of magnesium ions using magnesium biosensor Natasha S, Malon RSP,Wicaksono DHB, Corcoles EP, Hermawan H Facultyof Biosciences and Medical Engineering, Universiti Teknologi Malaysia (UTM),Malaysia Todevelop a real time 原理: Kinase enzyme Cotton-basedanalytical device SOP18. Effect ofstress on the corrosion behaviour of magnesium wire in m-SBF Zhang S, Li X, Wu H,Zhao C, Liu J, Zhang Y, Zhang X Schoolof Materials Science and Engineering, Shanghai Jiao Tong University, China 0.3mmin diameter Surgicalstaple nail in U-shape and after use it becomes B-shape 0MPa—20MPa: 550h—250h SOP19. Nanorod-shapedhydroxyapatite formed on pure magnesium by Micro-arc oxidation and hydrothermaltreatment Han Y, Li B State-keyLab for Mechanical Behavior of Materials, Xi’an Jiaotong University, Xi’an710049, China () 源于他们在 Ti 上的工作 SOP20.Inhibitor-loaded chitosan coatings on the microarc oxidized Mg-1Ca alloy Jia ZJ, Li M, Liu Q,Xu XC, Cheng Y, Zheng YF, Xi TF, Wei SC Centerfor Biomedical Materials and Tissue Engineering, Academy for AdvancedInterdisciplinary Studies, Peking University, China MAO-Mg-Ca 后甩上壳聚糖 SOP21. In vitrobiocorrosion behavior of Mg-Nd-Zn-Zr alloy evaluated by different methods Zhang X, Yuan G, WangZ, Xue Y Schoolof Materials Science and Engineering, Nanjing Institute of Technology, China T4,E, EA 三种处理 SOP22. Corrosionbehaviour of Mg-aCa-bY extrusions in simulated body fluid Yim CD, Woo SK, KimYM, You BS Light Metal Division, Korea Institute of MaterialsScience, South Korea SOP23. AbsorbableMg-ND composite and Zn alloy for surgical implant application Zhou J, Gong H, Yao D MechanicalEngineering and Mechanics Department, Drexel University, USA Highenergy ultrasonication assisted mixing process NanoCeO2+ Mg 复合材料 Zn-1Mg,weight loss rate is low, but implant can lose intergrity in weeks SOP24. Hydroxyapatiteand octacalcium phosphate coating of bioabsorbable Mg-Ca alloys by a novelchemical solution deposition method Hiromoto S, Hanada K,Matsuzaki K BiomaterialsUnit, National Institute HAand OCP coating on Mg-Ca by chemical solution deposition methods at pH value6.1 and 8.9 H2evolution rate 0.01-0.03 mlNaN2/day 下午报告会: in vitro session K3: In vitrostrategies to mimic in vivo events after osseous implantation Luthringer BJC, Wu L,Costantino M, Burmester A, Schiling AF, Feyerabend F, Wilumeit R Departmentfor Structural Research on Macromolecules, Institute of Materials Research,Helmholtz-Centre Geesthacht, Geesthacht, Germany Whichare the correct environmental parameters, (mechanical, corrosive, cytotoxicity,genotoxicity) Animalexperimental ---Problematic Literatures:Primary OB, MG63, SAOA2 U2OS MC3T3, are all cell types suitable for Mg tests? Areother cell types needed to study Mg degradation? GUT2008; 57:684-694 Osteoblastsas cell model for Mg studies OsmolalityDMEM 0.319 Cellsize of adherent cells 受镁离子影响 Geneexpression qualitative RT-PCR 受镁离子影响 Useprimary cells whenever possible Itmatters in which form the Mg is present Howare Osteoclast influenced? Cellmodel: peripheral blood mononuclear cells(PBMC) Numberof OCs seems to be reduced OB/OCco-culture to test Mg RatioOC/OB: 100:1 without RANKL and MCSF Firstresults with Macrophages Establishmentof a suitable model: cell line U937 Co-culturewith OB in the future Thecorrect octeoblast model : primary cells AlsoOCs are influenced may be even better model OB/OCco-culture give different results---See if the degradation is different O12. Influence ofstrontium concentration on in vitro corrosion property and cytocompatiblity ofternary Mg-Zn-Sr alloys Tie D, Guan RG, Cui T,Wu LL, Song LL, Qin HM NortheasternUniversity, Shenyang, China 4 个成分 植入动物 16 周后,全部降解。 4mm/year 是铸态 O13. In vitro studieson Mg-Ge(-Ca, Zn) alloy system newly-developed for potential biomedicalapplications Zheng YF, Zhou WR,Ruan L StateKey Laboratory for Turbulence and Complex System and Department of MaterialsScience and Engineering, College of Engineering, Peking University, China O14. Corrosion of zincin PBS, Ringer solution, blood plasma and whole blood Trne K, WeissenriederAN, Weissenrieder J MaterialsPhysics, KTH Royal Institute of Technology, Kista, Sweden 2011 年开始,和 ST.Jude Medical 合作 Plasma270micrometer /y; J.Electrochem Soc. 1988, 135:332-339 ElectrochimActa 2009 54:1204-1209 PBSZn2(PO4)2.4H2O RingerZn5(CO3)2… Corrosionresistance 在不同溶液不同 以下为 5 分钟的短报告 O15. Cytotoxicityevaluation of Mg-Sn-Mn alloy on mouse fibroblasts Yang L, Zhen Z, Lai C,Xi TF Centerfor Biomedical Materials and Tissue Engineering, Academy for AdvancedInterdisciplinary Studies, Peking University, Beijing, China 蛋白质组学研究,我代讲 SOP25.Degradation and cytocompatibility of magnesium alloys formedical applications –an introduction to methods and observations LiuH InterdisciplinaryMaterials Science and Engineering Program, Bourns College of Engineering,University of California, Riverside, CA. USA ACL 界面螺钉 体外研究: AZ31 Pure Mg 比 mg-4Y 降解慢, SOP26.Preincubation increases in vitro cell adhesion to magnesium and its alloys FeyerabendF, Mohring A, Wilumeit R Helmholtz-ZentrumGeesthacht, Geesthacht, Germany Directapplication of cells on Mg materials often is not working Whynot try a preincubation step? Woundhealing is time consuming Mg10Gd1Ndextruded Increasein preincubation time increase cell adhesion and reduce the amount of dead cells Canthis be related to the corrosion layer? YES Na7Mg13Nd(PO4)12 SOP27.Assessment of cellular effects in the vicinity of Mg, AZ31 and ZEK100 alloys GrilloCA, Alvarez F, Muller WD, Fernandez Lorenzo de Mele M Charité Universitaetsmedizin Berlin, Germany SOP28. Bioresorbablemetallic interference screws for anterior cruciate ligament reconstruction – anevaluation of mechanical and degradation properties Patel T, Iskandar ME,Liu H Interdisciplinary Materials Science and EngineeringProgram, Bourns College of Engineering, University of California, Riverside,CA. USA SOP29. Effect ofproteins and cells on degradation behaviour of Mg-Nd-Zn-Zr alloy Zhang J, Kong N, LiHY, Yuan GY Schoolof Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China 用了 FBS=fetal bovine serum, ECGS=endotheialcell growth supplement HUVEC Proteindecrease Mg alloy degradation rate Cellsincrease Mg alloy degradation rate SOP30.Characterization of hydroxyapatite containing micro-arc oxidation coating onZK60 magnesium alloy Lin X, Yang XM, TanLL, Zhang Y, Yang K Instituteof Metal Research, Chinese Academy of Sciences, Shenyang, China HA 涂层 SOP31. The degradationrate and cytocompatibility of Zn-3Mg alloy Dambatta MS, Mrni NS,Sudin I, Hermawan H Facultyof Mechanical Engineering, Universiti Teknologi Malaysia (UTM), Malaysia Zn 《 MgStrength ; corrosion resistance ZnMg COMETASSAY it does not cause DNA damage to NHOst 0.75mg/mlis the maximum for Zn-3Mg which is cytocompatible SOP32. In vitrodegradation and biocompatibility of ZK60 magnesium alloy with Sr-containingmicro-arc oxidation coating Lin X, Yang XM, TanLL, Zhang Y, Yang K Instituteof Metal Research, Chinese Academy of Sciences, Shenyang, China P 、 Sr-P 涂层 SOP33. Anticorrosionand cytocompatibility of biodegradable polylactide/MgO composite coating onAZ31 alloy Tian P, Liu XY Shanghai Institute of Ceramics, Chinese Academy ofSciences, Shanghai 200050, China SOP34. The interactionof fibroblast cells on the surface of porous iron Daud NM, Hermawan H Faculty of Biosciences and Medical Engineering,University Teknologi Malaysia (UTM), Malaysia BIOMETAL2014 讨论 What, Where, When Isolateplace with attendees occupying the entire hotel Keywords:learning, sharing, discussing, networking, exchanging, meeting Logistic:healthy, safeness, cleanness, affordable cost, all included registeration rate Eco-responsibleand unconventional 2009Berlin 4 companies/2 sponsors 2010-Maratea7 companies/4 sponsors 2011Quebec City 10 companies/6 sponsors 2012-Maratea11 companies/7 sponsors 2013-Umang island, Indonesia, ASIA-PACIFIC edition 5 companies/2 sponsors 选择一: Maratea Advantages:hotel will be ours Safeness,not extreme, accessable 28Aug- 2 Sept 选择二: Malta Inconvenient/advantage Dispersedin hotel, date/new location IntercontinentalHotel St Gillians, 4*, Malta 可以从 Frankfurt 转机 3-8Nov or 10-15 Nov
请访问 http://www.biodegradablemetals.org/ Umang Island welcomes the 5 th Symposium on Biodegradable Metals Following the successes of the past four editions, we are proud to welcome you to the 5 th Symposium on Biodegradable Metals in Umang Island, Indonesia from Sunday August 25th to Saturday August 31st, 2013. This year again, the symposium will be characterized by its academic-conference-style with an openly discursive format, rather than a lecture and question–answer format. This style will be completed by the traditional discussions at the end of each session and the unconventional daily beach session early in the afternoon. Besides the presentations, this symposium aims to discuss open questions on the session topics, new approaches, background knowledge, and personal views among the participants. Furthermore, discussions at the poster session will focus on specific topics and will encourage the participants to raise critical questions or help each other advancing the field of biodegradable metals. The tropical environment offered by the beauty of the Umang Island, and overall Indonesia, will well complete the experience we intend to offer to all attendees. The location was especially selected for the 5 th Biometal 2013 to be closer to our numerous Australasian attendees. Please join us to deepen our knowledge in the field and to discover this part of the world! If potentially interested, we strongly suggest you to do not wait last minute to register as the number of attendees is limited and registration will be treated on a first-come, first-served basis. We really hope to welcome you in Umang Island next August! Co-Chairs Prof. Diego Mantovani, Prof. Mark Staiger, Prof. Yufeng Zheng, Prof. Frank Witte
Dear Colleagues and Friends : On behalf of the Organising Committee, I would like to inform you that next Biometal-2013 will be held in Umang Island, Indonesia from Sunday 25 to Saturday 31 August 2012. Please be advised we were obliged to advance the starting date from Monday 26 to Saturday 25 August, 2013. We strongly invite you to mark your calendar. We promise this will be a unforgettable conference, from scientific, social and cultural/touristic point of views. Umang Island is at the same time: - a very calm and isolated place suitable for critical thinking and sharing ideas; - a very charming tropical island, paradise for snorkelling and scuba diving, as well as jungle trekking, rhinoceros observation, tropical fishing on bamboo platforms, underwater volcanos seeing, and many others; Umang is one the rare place on earth where sunset and sunrise are available …. We really hope to meet you again next year there! The website will be available in January. Please accept our best wishes for a Wonderful 2013! Our deepest wishes to you and your family for a Happy New Year. Diego Mantovani on behalf of the Organising Committee
印尼苏门答腊发生 6 级地震( 2008-11-28 6.10pm ) 早报导读 (雅加达讯)美国地质研究局说,印尼苏门答腊岛附近海域下午发生 6 级地震,暂无海啸警告和伤亡报告。 地震发生在当地时间下午 3 时 50 分 ( 本地时间下午 4 时 50 分 ) ,震央在明古鲁市西南偏南 141 公里 ,深度为 35 公里 。 《联合早报网》 (编辑:黄爱莲) http://realtime.zaobao.com/2008/11/081128_39.shtml Recent Earthquakes 11/28/2008 M 5.8, off the coast of Northern California( 加利福尼亚北部 40.336N, 126.981W) 11/28/2008 M 6.0, southern Sumatra, Indonesia( 印度尼西亚 4.747S, 101.744E) 11/27/2008 M 5.9, Vanuatu (瓦努阿图17.796S, 167.523E) http://www.iris.edu/hq/audience/public/earthquakes GFZ Potsdam GEOFON Global Seismic Monitor GFZ Potsdam - Earthquake Bulletin New search Legend Origin Time UTC Mag Latitude degrees Longitude degrees Depth km AM Region Name 2008-11-28 19:45:30 5.0 33.14 N 141.02 E 70 A Off East Coast of Honshu , Japan 2008-11-28 14:00:33 4.5 8.50 S 111.57 E 112 M Java, Indonesia 2008-11-28 13:42:30 5.1 40.71 N 126.11 W 10 A Off Coast of N. California 2008-11-28 11:04:00 5.1 14.00 N 121.21 E 97 A Luzon, Philippines 2008-11-28 09:53:10 5.1 12.83 N 143.21 E 106 A South of Mariana Islands 2008-11-28 09:38:17 4.9 22.64 N 44.95 W 10 A Northern Mid Atlantic Ridge 2008-11-28 08:50:50 6.0 4.60 S 101.75 E 21 A Southern Sumatra, Indonesia 2008-11-28 07:59:45 5.0 48.16 N 154.99 E 53 A Kuril Islands 2008-11-28 01:34:03 5.3 22.60 S 175.31 W 10 A Tonga Islands Region 2008-11-27 20:43:46 4.9 7.37 S 126.62 E 446 A Banda Sea 2008-11-27 17:31:32 5.5 17.84 S 167.45 E 24 A Vanuatu Islands 2008-11-27 09:17:52 5.2 41.65 S 85.28 E 10 A Southeast Indian Ridge 2008-11-27 04:37:13 4.9 25.10 S 177.79 E 556 A South of Fiji Islands 2008-11-27 03:04:57 5.3 15.91 S 73.42 W 55 A Southern Peru 2008-11-27 01:04:07 4.8 13.65 N 120.52 E 37 A Mindoro, Philippines 2008-11-26 21:46:42 4.9 17.88 S 167.22 E 66 A Vanuatu Islands 2008-11-26 15:43:49 4.3 16.71 S 174.22 W 209 M Tonga Islands 2008-11-26 07:02:28 4.7 29.80 N 51.83 E 25 M Southern Iran 2008-11-26 05:25:24 4.7 5.94 S 106.72 E 264 A Java, Indonesia 2008-11-26 04:47:05 5.2 4.85 S 68.75 E 10 A Chagos Archipelago Region 2008-11-26 04:02:12 5.6 20.58 S 169.06 E 60 A Vanuatu Islands 2008-11-25 22:13:24 4.7 29.96 N 52.02 E 34 A Southern Iran 2008-11-25 19:38:13 4.8 17.95 N 146.62 E 155 A Mariana Islands 2008-11-25 15:05:41 5.1 21.96 S 33.28 E 29 M Mozambique 2008-11-25 15:04:45 5.3 22.66 S 175.53 W 10 A Tonga Islands Region 2008-11-25 12:40:07 5.4 18.02 N 147.05 E 10 A Mariana Islands Region 2008-11-25 10:21:27 5.0 7.92 N 124.29 E 21 A Mindanao, Philippines 2008-11-25 06:03:13 5.1 19.42 S 169.60 E 10 A Vanuatu Islands 2008-11-25 01:36:35 5.6 29.80 S 177.93 W 53 A Kermadec Islands , New Zealand 2008-11-25 01:19:45 4.8 47.22 S 10.49 W 10 M Southern Mid Atlantic Ridge 2008-11-24 19:53:39 5.2 5.91 S 147.12 E 120 A Eastern New Guinea Reg., P.N.G. 2008-11-24 18:44:21 5.1 52.93 N 159.63 E 60 A Off East Coast of Kamchatka 2008-11-24 09:02:58 7.0 54.28 N 154.31 E 497 A Sea of Okhotsk 2008-11-24 07:04:35 4.4 13.83 N 93.11 W 10 M Off Coast of Chiapas , Mexico 2008-11-23 21:19:46 5.3 36.27 S 72.63 W 51 A Near Coast of Central Chile 2008-11-23 18:06:42 4.7 17.40 N 93.75 W 180 A Chiapas , Mexico 2008-11-23 12:18:53 4.9 21.76 S 177.26 W 228 A Fiji Islands Region 2008-11-23 11:57:51 5.5 4.68 S 153.06 E 78 A New Ireland Region, P.N.G. 2008-11-23 10:19:06 5.0 30.99 N 104.06 E 10 A Sichuan , China 2008-11-23 09:12:08 5.0 22.52 S 171.10 E 49 A Southeast of Loyalty Islands http://geofon.gfz-potsdam.de/db/eqinfo.php GFZ Potsdam GEOFON Global Seismic Monitor GFZ Potsdam - Earthquake Bulletin Region: Southern Sumatra , Indonesia Time: 2008-11-28 08:50:50.5 UTC Magnitude: 6.0 Epicenter: 101.75E 4.60S Depth: 21 km Status: automatic http://geofon.gfz-potsdam.de/db/eqpage.php?id=gfz2008xiwj