http://www.bioon.com/biology/postgenomics/459885.shtml Nat.Genetics：发现6个新的银屑病易感基因 10月18日，安徽医科大学皮肤科研究所张学军教授团队联合了美国密歇根大学、华盛顿大学，德国吉尔大学和复旦大学华山医院等国内外30多家单位共同在线发表中外科学家合作研究发现6个新的银屑病易感基因的研究成果。 http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.690.html Letter Nature Genetics Published online: 17 October 2010 | :10.1038/ng.690 :10.1038/ng.690 Article Links Supplementary information Article Tools Send to a friend Export citation Export references Rights and permissions Order commercial reprints Bookmark in Connotea Search Pubmed for Liang-Dan Sun Hui Cheng Zai-Xing Wang An-Ping Zhang Pei-Guang Wang Jin-Hua Xu more authors of this article Association analyses identify six new psoriasis susceptibility loci in the Chinese population Liang-Dan Sun 1 , 2 , 3 , 18 , Hui Cheng 1 , 2 , 3 , 18 , Zai-Xing Wang 1 , 2 , 3 , 18 , An-Ping Zhang 1 , 2 , 3 , 18 , Pei-Guang Wang 1 , 2 , 3 , 18 , Jin-Hua Xu 4 , Qi-Xing Zhu 1 , 2 , 3 , Hai-Sheng Zhou 3 , 5 , Eva Ellinghaus 6 , Fu-Ren Zhang 2 , 7 , Xiong-Ming Pu 2 , 8 , Xue-Qin Yang 2 , 9 , Jian-Zhong Zhang 10 , Ai-E Xu 2 , 11 , Ri-Na Wu 12 , Li-Min Xu 13 , Lin Peng 14 , Cynthia A Helms 14 , Yun-Qing Ren 1 , 2 , 3 , Chi Zhang 1 , 2 , 3 , Shu-Mei Zhang 1 , 3 , Rajan P Nair 15 , Hong-Yan Wang 1 , 2 , 3 , Guo-Shu Lin 1 , 2 , 3 , Philip E Stuart 15 , Xing Fan 1 , 2 , 3 , Gang Chen 2 , 3 , Trilokraj Tejasvi 15 , Pan Li 1 , 2 , 3 , Jun Zhu 1 , 2 , 3 , Zhi-Ming Li 1 , 2 , 3 , Hong-Mei Ge 1 , 2 , 3 , Michael Weichenthal 16 , Wen-Zheng Ye 1 , 2 , 3 , Cheng Zhang 1 , 2 , 3 , Song-Ke Shen 1 , 2 , 3 , Bao-Qi Yang 7 , Yuan-Yuan Sun 1 , 2 , 3 , Shan-Shan Li 1 , 2 , 3 , Yan Lin 1 , 2 , 3 , Jian-Hua Jiang 8 , Cun-Tao Li 1 , 2 , 3 , Ri-Xin Chen 1 , 2 , 3 , Juan Cheng 9 , Xin Jiang 1 , 2 , 3 , Peng Zhang 1 , 2 , 3 , Wei-Min Song 11 , Jin Tang 1 , 2 , 3 , Hao-Qin Zhang 1 , 2 , 3 , Li Sun 12 , Jing Cui 1 , 2 , 3 , Li-Jun Zhang 1 , 2 , 3 , Biao Tang 1 , 2 , 3 , Fei Huang 1 , 2 , 3 , Qian Qin 1 , 2 , 3 , Xiao-Ping Pei 1 , 2 , 3 , Ai-Min Zhou 13 , Li-Mei Shao 1 , 2 , 3 , Jian-Lan Liu 1 , 2 , 3 , Feng-Yu Zhang 1 , 3 , Wei-Dong Du 1 , 3 , Andre Franke 6 , Anne M Bowcock 14 , James T Elder 15 , Jian-Jun Liu 1 , 3 , 17 , Sen Yang 1 , 2 , 3 Xue-Jun Zhang 1 , 2 , 3 , 4 Abstract We extended our previous genome-wide association study for psoriasis with a multistage replication study including 8,312 individuals with psoriasis (cases) and 12,919 controls from China as well as 3,293 cases and 4,188 controls from Germany and the United States and 254 nuclear families from the United States. We identified six new susceptibility loci associated with psoriasis in the Chinese study containing the candidate genes ERAP1 , PTTG1 , CSMD1 , GJB2 , SERPINB8 and ZNF816A (combined P 5 10 8 ) and replicated one locus, 5q33.1 ( TNIP1-ANXA6 ), previously reported (combined P = 3.8 10 21 ) in the European studies. Two of these loci showed evidence for association in the German study at ZNF816A and GJB2 with P = 3.6 10 3 and P = 7.9 10 3 , respectively. ERAP1 and ZNF816A were associated with type 1 (early onset) psoriasis in the Chinese Han population (test for heterogeneity P = 6.5 10 3 and P = 1.5 10 3 , respectively). Comparisons with the results of previous GWAS of psoriasis highlight the heterogeneity of disease susceptibility between the Chinese and European populations. Our study identifies new genetic susceptibility factors and suggests new biological pathways in psoriasis. To read this story in full you will need to login or make a payment (see right).
王立东教授和肿瘤研究同行们最清楚，发现一个肿瘤易感基因有多么伟大，河南的动作过大啦，媒体会害死人的，科学家必须保持冷静。 Nat Genet. 2010 Aug 22.同时发表了美国癌症研究所（NCI）Abnet CC等人的类似研究结果，美国没有什么动静呢。 食管癌易感基因 吴红龙 详细见 http://www.sciencenet.cn/m/user_content.aspx?id=356570#t1 孙学军 科研中最重要的是思路 http://www.sciencenet.cn/m/user_content.aspx?id=356561 附相关报道和 论文全文 和 论文附件 本报新乡8月22日电 国际著名学术期刊《自然遗传学》(NatureGenet-ics),今天在线发表了由河南新乡医学院癌症研究中心主任、特聘教授王立东博士领衔的一项重大研究成果:利用全基因组关联分析(GWAS)方法,在人类第10号和20号染色体上首次发现两个食管癌易感基因(PLCE1和C20orf54),这是目前国际上规模最大的食管癌全基因组关联分析研究,标志着我国食管癌易感基因研究居于国际先进水平。 同一天，发表了两篇类似的研究结果。 1. Nat Genet. 2010 Aug 22. Genome-wide association study of esophageal squamous cell carcinoma in Chinesesubjects identifies susceptibility loci at PLCE1 and C20orf54. Wang LD, Zhou FY, Li XM, Sun LD, Song X, Jin Y, Li JM, Kong GQ, Qi H, Cui J,Zhang LQ, Yang JZ, Li JL, Li XC, Ren JL, Liu ZC, Gao WJ, Yuan L, Wei W, Zhang YR,Wang WP, Sheyhidin I, Li F, Chen BP, Ren SW, Liu B, Li D, Ku JW, Fan ZM, Zhou SL,Guo ZG, Zhao XK, Liu N, Ai YH, Shen FF, Cui WY, Song S, Guo T, Huang J, Yuan C,Huang J, Wu Y, Yue WB, Feng CW, Li HL, Wang Y, Tian JY, Lu Y, Yuan Y, Zhu WL, LiuM, Fu WJ, Yang X, Wang HJ, Han SL, Chen J, Han M, Wang HY, Zhang P, Li XM, DongJC, Xing GL, Wang R, Guo M, Chang ZW, Liu HL, Guo L, Yuan ZQ, Liu H, Lu Q, YangLQ, Zhu FG, Yang XF, Feng XS, Wang Z, Li Y, Gao SG, Qige Q, Bai LT, Yang WJ, Lei GY, Shen ZY, Chen LQ, Li EM, Xu LY, Wu ZY, Cao WK, Wang JP, Bao ZQ, Chen JL, DingGC, Zhuang X, Zhou YF, Zheng HF, Zhang Z, Zuo XB, Dong ZM, Fan DM, He X, Wang J, Zhou Q, Zhang QX, Jiao XY, Lian SY, Ji AF, Lu XM, Wang JS, Chang FB, Lu CD, Chen ZG, Miao JJ, Fan ZL, Lin RB, Liu TJ, Wei JC, Kong QP, Lan Y, Fan YJ, Gao FS, Wang TY, Xie D, Chen SQ, Yang WC, Hong JY, Wang L, Qiu SL, Cai ZM, Zhang XJ. Cancer Research Center, Xinxiang Medical University, Xinxiang, Henan, China. Henan Key Laboratory for Esophageal Cancer Research, Department of BasicOncology and Pathology at College of Medicine, The First and The Second Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China. We performed a genome-wide association study of esophageal squamous cellcarcinoma (ESCC) by genotyping 1,077 individuals with ESCC and 1,733 control subjects of Chinese Han descent. We selected 18 promising SNPs for replication inan additional 7,673 cases of ESCC and 11,013 control subjects of Chinese Han descent and 303 cases of ESCC and 537 control subjects of Chinese Uygur-Kazakh descent. We identified two previously unknown susceptibility loci for ESCC: PLCE1 at 10q23 (P(Han combined for ESCC) = 7.46 x 10(-56), odds ratio (OR) = 1.43; P(Uygur-Kazakh for ESCC) = 5.70 x 10(-4), OR = 1.53) and C20orf54 at 20p13 (P(Han combined for ESCC) = 1.21 x 10(-11), OR = 0.86; P(Uygur-Kazakh for ESCC) = 7.88 x 10(-3), OR = 0.66). We also confirmed association in 2,766 cases of gastric cardia adenocarcinoma cases and the same 11,013 control subjects (PLCE1, P(Han for GCA) = 1.74 x 10(-39), OR = 1.55 and C20orf54, P(Han for GCA) = 3.02 x 10(-3), OR = 0.91). PLCE1 and C20orf54 have important biological implications for both ESCC and GCA. PLCE1 might regulate cell growth, differentiation, apoptosis and angiogenesis. C20orf54 is responsible for transporting riboflavin, and deficiency of riboflavin has been documented as a risk factor for ESCC and GCA. PMID: 20729853 2. Nat Genet. 2010 Aug 22. A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma. Abnet CC, Freedman ND, Hu N, Wang Z, Yu K, Shu XO, Yuan JM, Zheng W, Dawsey SM,Dong LM, Lee MP, Ding T, Qiao YL, Gao YT, Koh WP, Xiang YB, Tang ZZ, Fan JH, WangC, Wheeler W, Gail MH, Yeager M, Yuenger J, Hutchinson A, Jacobs KB, Giffen CA, Burdett L, Fraumeni JF Jr, Tucker MA, Chow WH, Goldstein AM, Chanock SJ, Taylor PR. Division of Cancer Epidemiology and Genetics, National Cancer Institute(NCI), National Institutes of Health, Bethesda, Maryland, USA. These authors contributed equally to this work. We conducted a genome-wide association study of gastric cancer and esophageal squamous cell carcinoma (ESCC) in ethnic Chinese subjects in which we genotyped 551,152 SNPs. We report a combined analysis of 2,240 gastric cancer cases, 2,115 ESCC cases and 3,302 controls drawn from five studies. In logistic regression models adjusted for age, sex and study, multiple variants at 10q23 had genome-wide significance for gastric cancer and ESCC independently. A notable signal was rs2274223, a nonsynonymous SNP located in PLCE1, for gastric cancer (P= 8.40 x 10(-9); per-allele odds ratio (OR) = 1.31) and ESCC (P = 3.85 x 10(-9); OR = 1.34). The association with gastric cancer differed by anatomic subsite. For tumors in the cardia the association was stronger (P = 4.19 x 10(-15); OR =1.57), and for those in the noncardia stomach it was absent (P = 0.44; OR =1.05). Our findings at 10q23 could provide insight into the high incidence of both cancers in China. PMID: 20729852
Start A-Literature C-Literature B-list Filter Literature A-query: BRCA1 or BRCA2 C-query: breast cancer or ovarian cancer The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 6419 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here . The results of this search are saved under id # 12382 and can be accessed from the start page after you leave this session. There are 144 terms on the current B-list ( 70 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin. To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms. Rank Prob B-term 10.98platinum based chemotherapy 20.98atm gene 30.97single nucleotide 40.97cancer xenograft 50.97small interfering rna 60.96platinum complex 70.96complementation group 80.96ubiquitin proteasome system 90.95atm dependent 100.95dna copy number 110.94poly adp 120.94co activator 130.94estrogen responsive 140.93|--estrogen responsive gene 150.93histone modification 160.93atm 170.93eralpha negative 180.93high throughput dna 190.92cox-2 gene expression 200.92homology directed dna 210.91oxygen species 220.91aromatase expression 230.91activation mapk 240.91deacetylase inhibitor induced 250.91suppressor protein 260.90mrna expression 270.89pancreatic adenocarcinoma 280.89pancreatic cancer risk 290.89chromatin remodeling complex 300.88damage checkpoint protein 310.87reactive oxygen 320.86expression androgen 330.85tubulin binding 340.85protein expression 350.84aberrant dna 360.84species human cancer 370.84xenograft 380.82growth factor beta 390.81differentially methylated 400.81function estrogen receptor 410.81insulin growth 420.81laminin rich 430.80novel nuclear protein 440.80activation estrogen 450.79adjuvant treatment 460.78inhibitor poly adp 470.77estrogen exposure 480.76high dose melphalan 490.74expression androgen receptor 500.74expression chromatin remodeling 510.74damage response mediator 520.74transplacental arsenic 530.74polymorphism nucleotide excision 540.73mcf-10a breast epithelial 550.72high density oligonucleotide 560.72linker sensitive 570.72regulation dna 580.71mutagen sensitivity 590.69histone variant 600.68cryptic splice site 610.66oncogenic function 620.66specific dna 630.65regulation insulin growth 640.64terminal hydrolase 650.64cycle regulatory protein 660.60ubiquitin specific 670.60active chromatin 680.59dna cleavable complex 690.59novel protein kinase 700.59leucine rich 710.58protein protein interaction 720.58pancreatic cancer cell 730.56rna screen gene 740.56free tumor dna 750.55rna screen 760.51regulation matrix metalloproteinase-9 770.50dual specificity phosphatase 780.46oxidative damage 790.45function estrogen 800.44expression chromatin 810.43pancreatic tumor cell 820.42defective dna 830.42chromatin structure 840.39ligase function 850.38formation dna 860.36induced oxidative 870.33specific protease 880.33expression dna 890.32identify estrogen receptor 900.31inhibition poly adp 910.30zinc binding 920.30protection oxidative 930.29novel protein 940.23activation stress 950.22regulation androgen 960.19alpha dna 970.17protein expression pattern 980.13effect curcumin 990.12proline rich 1000.12modification dna 1010.11meiotic 1020.11oxidative 1030.11signal 1040.10newly identified protein 1050.10change protein expression 1060.10responsive protein 1070.07pancreatic 1080.06directly 1090.06regulation growth hormone 1100.05direction 1110.05effect dna 1120.05specific inhibitor 1130.05overexpression dna 1140.052-d 1150.03beta d-glucopyranoside 1160.02carcinogen exposure 1170.02protein cellular 1180.02new protein 1190.02abnormal protein 1200.02common dna 1210.01directional 1220.01genetic basis 1230.01protein control 1240.01universal 1250.01t 1260.00inhibitory effect 1270.00retention protein 1280.00cellular basis 1290.00code 1300.00central nervous 1310.00effect protein 1320.00central 1330.00complex protein 1340.00stress low 1350.00new direction 1360.00direct 1370.00concept 1380.00protein different 1390.00central role 1400.00evidence direct 1410.00san 1420.00active 1430.00biological basis 1440.00speed Restrict by semantic categories? http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi job id # 12382 started Wed Apr 21 03:52:36 2010 Max_citations: 50000 Stoplist: /var/www/html/arrowsmith_uic/data/stopwords_pubmed Ngram_max: 3 12382 Search ARROWSMITH A A_query_raw: BRCA1 or BRCA2Wed Apr 21 03:53:23 2010 A query = BRCA1 or BRCA2 started Wed Apr 21 03:53:24 2010 A query resulted in 8115 titles 12382 Search ARROWSMITH C C_query_raw: breast cancer or ovarian cancer Wed Apr 21 03:53:56 2010 C: breast cancer or ovarian cancer 267201 A: pubmed_query_A 8115 AC: ( BRCA1 or BRCA2 ) AND ( breast cancer or ovarian cancer ) 6419 C query = breast cancer or ovarian cancer started Wed Apr 21 03:53:58 2010 C query resulted in 50000 titles A AND C query resulted in 6419 titles 6167 B-terms ready on Wed Apr 21 03:57:26 2010 Sem_filter: Concepts Ideas 1563 B-terms left after filter executed Wed Apr 21 04:01:30 2010 1563 B-terms left after filter executed Wed Apr 21 04:01:37 2010 Sem_filter: Chemicals Drugs 144 B-terms left after filter executed Wed Apr 21 04:04:22 2010 B-list on Wed Apr 21 04:06:14 2010 1 platinum based chemotherapy 2 atm gene 3 single nucleotide 4 cancer xenograft 5 small interfering rna 6 platinum complex 7 complementation group 8 ubiquitin proteasome system 9 atm dependent 10 dna copy number 11 poly adp 12 co activator 13 estrogen responsive 14 estrogen responsive gene 15 histone modification 16 atm 17 eralpha negative 18 high throughput dna 19 cox-2 gene expression 20 homology directed dna 21 oxygen species 22 aromatase expression 23 activation mapk 24 deacetylase inhibitor induced 25 suppressor protein 26 mrna expression 27 pancreatic adenocarcinoma 28 pancreatic cancer risk 29 chromatin remodeling complex 30 damage checkpoint protein 31 reactive oxygen 32 expression androgen 33 tubulin binding 34 protein expression 35 aberrant dna 36 species human cancer 37 xenograft 38 growth factor beta 39 differentially methylated 40 function estrogen receptor 41 insulin growth 42 laminin rich 43 novel nuclear protein 44 activation estrogen 45 adjuvant treatment 46 inhibitor poly adp 47 estrogen exposure 48 high dose melphalan 49 expression androgen receptor 50 expression chromatin remodeling 51 damage response mediator 52 transplacental arsenic 53 polymorphism nucleotide excision 54 mcf-10a breast epithelial 55 high density oligonucleotide 56 linker sensitive 57 regulation dna 58 mutagen sensitivity 59 histone variant 60 cryptic splice site 61 oncogenic function 62 specific dna 63 regulation insulin growth 64 terminal hydrolase 65 cycle regulatory protein 66 ubiquitin specific 67 active chromatin 68 dna cleavable complex 69 novel protein kinase 70 leucine rich 最新研究报道： 德科学家研究发现乳腺癌和卵巢癌易感基因 2010-04-21 14:28:55 来源: 新华网 新华网柏林4月20日电(记者班玮)德国癌症援助协会19日发表公报说,德国研究人员最近发现了可导致乳腺癌和卵巢癌的一个新易感基因。 公报说,由德国12所大学研究人员参加的德国家族性乳腺癌和卵巢癌研究组织对1100个有家族病史的家庭进行了基因组相关性研究,并发现了这个被命名为RAD51C的新易感基因。 有关专家说,此前人们已知的两个乳腺癌和卵巢癌易感基因是15年前发现的,分别为BRCA1和BRCA2,它们发生变异会导致乳腺癌或卵巢癌。本次接受研究的家庭成员已被确认没有BRCA1和BRCA2基因变异。 研究人员说,因为目前只有大约60%的高风险家庭携带已知的乳腺癌和卵巢癌易感基因,乳腺癌和卵巢癌可能还有其他易感基因。确定易感基因是提高早期诊断率的重要前提。 这一研究成果已发表在最新一期英国《自然遗传学》杂志上。
标签: 易感基因
