科学家揭秘急性癌症成因:染色体爆炸破坏DNA http://news.sciencenet.cn/htmlnews/2011/1/242576.shtm 英国科学家找到了急性癌症的形成原因:细胞内的染色体发生爆炸破坏了DNA,从而让人有可能在短时间内患上癌症。 Why some cancers seems to develop in an instant - cells can explode wreaking havoc in DNA http://www.dailymail.co.uk/health/article-1344740/Why-cancers-develop-instant--cells-explode-wreaking-havoc-DNA.html The mystery of 'instant cancers' - tumours that seem to appear out of nowhere - has been solved by British scientists. In some cases, a single apocalyptic explosion in a cell can cause as much damage to the DNA as decades of hard living. http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi Start A-Literature C-Literature B-list Filter Literature A-query: instant cancers C-query: DNA damage The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 6 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here . The results of this search are saved under id # 13989 and can be accessed from the start page after you leave this session. There are 426 terms on the current B-list ( 89 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin. To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms. job id # 13989 started Sun Jan 9 22:35:53 2011 Max_citations: 50000 Stoplist: /var/www/html/arrowsmith_uic/data/stopwords_pubmed Ngram_max: 3 13989 Search ARROWSMITH A A_query_raw: instant cancersSun Jan 9 22:36:11 2011 A query = instant cancers started Sun Jan 9 22:36:11 2011 A query resulted in 212 titles 13989 Search ARROWSMITH C C_query_raw: DNA damage Sun Jan 9 22:36:41 2011 C: DNA damage 85835 A: pubmed_query_A 212 AC: ( instant cancers ) AND ( DNA damage ) 6 C query = DNA damage started Sun Jan 9 22:36:42 2011 C query resulted in 50000 titles A AND C query resulted in 6 titles 1344 B-terms ready on Sun Jan 9 22:40:06 2011 Sem_filter: Concepts Ideas 426 B-terms left after filter executed Sun Jan 9 22:45:48 2011 B-list on Sun Jan 9 22:46:25 2011 1 non small cell 2 small cell lung 3 cancer xenograft 4 time rt pcr 5 linear quadratic 6 real time rt 7 small cell 8 melanoma progression 9 acute myeloid 10 superficial bladder 11 xenograft 12 chronic lymphocytic 13 treatment arsenic trioxide 14 b cell chronic 15 quantitative real time 16 nci 17 superficial bladder cancer 18 patient colorectal 19 formation lung 20 overexpression 21 intravesical 22 solitary fibrous tumor 23 cell chronic lymphocytic 24 colorectal 25 radiotherapy 26 chemotherapy 27 alteration apoptosis 28 specific cytotoxic t 29 orthotopic model 30 real time 31 surface plasmon 32 cancer therapy 33 estrogen receptor er 34 enhanced ultrasound induced 35 advanced breast cancer 36 myeloid 37 red fluorescent 38 status breast cancer 39 study oxidative 40 diagnosis breast cancer 41 focused ultrasound 42 duplication 43 fractionated radiotherapy 44 rt 45 bone health 46 antitumor action 47 primary breast 48 testicular 49 nasopharyngeal 50 cell specific 51 protein overexpression 52 oxidative 53 cell chronic 54 acute lymphoblastic 55 term exposure 56 multiple melanoma 57 radical 58 complex a 59 mechanistic 60 beam 61 specific cytotoxic 62 strategy induce tumor 63 ovarian 64 dosimetry 65 intraepithelial 66 lymphocytic 67 arrest 68 effect coffee 69 prostatic 70 online 71 fusion 72 mechanism antitumor 73 population based 74 neutron 75 axillary 76 medium term 77 proliferation 78 interleukin-6 level 79 primary liver 80 allogeneic stem cell 81 activator 82 scattering 83 allogeneic 84 heavy 85 endocrine treatment 86 rectal 87 worker 88 nuclear 89 orthotopic http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/show_sentences.cgi Start A-Literature C-Literature B-list Filter Literature AB literature B-term BC literature instant cancers small cell lung DNA damage 1: Involvement of calcium in the differential induction of heat shock protein 70 by heat shock protein 90 inhibitors, geldanamycin and radicicol, in human non -small cell lung cancer H460 cells.2006 Add to clipboard 1: Identification of microRNA profiles in docetaxel-resistant human non -small cell lung carcinoma cells (SPC-A1).2010 Add to clipboard 2: The close correlation between 8-hydroxy-2'-deoxyguanosine and epidermal growth factor receptor activating mutation in non -small cell lung cancer.2010 Add to clipboard 3: Genetic variation in glutathione metabolism and DNA repair genes predicts survival of small-cell lung cancer patients.2010 Add to clipboard 4: Targeting Epidermal Growth Factor Receptor-Associated Signaling Pathways in Non -Small Cell Lung Cancer Cells: Implication in Radiation Response.2010 Add to clipboard 5: Curcumin Induces Apoptosis in Human Non -small Cell Lung Cancer NCI-H460 Cells through ER Stress and Caspase Cascade- and Mitochondria-dependent Pathways.2010 Add to clipboard 6: Hypermethylation of growth Arrest DNA-damage-inducible gene 45 in non -small cell lung cancer and its relationship with clinicopathologic features.2010 Add to clipboard 7: 2010 Add to clipboard 8: Combinations of DNA Methyltransferase and Histone Deacetylase Inhibitors Induce DNA Damage in Small Cell Lung Cancer Cells: Correlation of Resistance with IFN-Stimulated Gene Expression.2010 Add to clipboard 9: NPRL2 Sensitizes Human Non -Small Cell Lung Cancer (NSCLC) Cells to Cisplatin Treatment by Regulating Key Components in the DNA Repair Pathway.2010 Add to clipboard 10: A Phase I Study of Concurrent Chemotherapy (Paclitaxel and Carboplatin) and Thoracic Radiotherapy with Swallowed Manganese Superoxide Dismutase (MnSOD) Plasmid Liposome (PL) Protection in Patients with Locally Advanced Stage III Non -Small Cell Lung Cancer.2010 Add to clipboard 11: The Nitric Oxide Prodrug JS-K is Effective Against Non -small Cell Lung Cancer Cells in vitro and in vivo : Involvement of Reactive Oxygen Species.2010 Add to clipboard 12: No evidence of an association of ERCC1 and ERCC2 polymorphisms with clinical outcomes of platinum-based chemotherapies in non -small cell lung cancer: A meta-analysis.2010 Add to clipboard 13: Effect of Ganoderma on drug-sensitive and multidrug-resistant small-cell lung carcinoma cells.2009 Add to clipboard 14: Sensitization to gamma-irradiation-induced cell cycle arrest and apoptosis by the histone deacetylase inhibitor trichostatin A in non -small cell lung cancer (NSCLC) cells.2009 Add to clipboard 15: XPG mRNA expression levels modulate prognosis in resected non -small-cell lung cancer in conjunction with BRCA1 and ERCC1 expression.2009 Add to clipboard 16: Epigenetic inactivation of checkpoint kinase 2 gene in non -small cell lung cancer and its relationship with clinicopathological features.2009 Add to clipboard 17: Single nucleotide polymorphism at rs1982073:T869C of the TGFbeta 1 gene is associated with the risk of radiation pneumonitis in patients with non -small-cell lung cancer treated with definitive radiotherapy.2009 Add to clipboard 18: Expression of an X-family DNA polymerase, pol lambda, in the respiratory epithelium of non -small cell lung cancer patients with habitual smoking.2009 Add to clipboard