Chemical strategies for pancreatic β cell differentiation, reprogramming, and regeneration Xiaojie Ma and Saiyong Zhu Acta Biochim Biophys Sin 2017, 49: 289–301; doi: 10.1093/abbs/gmx008 Generation of unlimited functional pancreatic β cells is critical for the study of pancreatic biology and treatment of diabetes mellitus. Recent advances have suggested several promising directions, including directed differentiation of pancreatic β cells from pluripotent stem cells, reprogramming of pancreatic β cells from other types of somatic cells, and stimulated proliferation and enhanced functions of existing pancreatic β cells. Small molecules are useful in generating unlimited numbers of functional pancreatic cells in vitro and could be further developed as drugs to stimulate endogenous pancreatic regeneration. Here, we provide an updated summary of recent major achievements in pancreatic β cell differentiation, reprogramming, proliferation, and function. These studies will eventually lead to significant advances in the field of pancreatic biology and regeneration. Approaches for making functional pancreatic β cells Improved protocols for directed differentiation of hPSCs into functional pancreatic β-like cells 阅读原文: http://www.abbs.org.cn/arts.asp?id=4135 获取全文: abbs@sibs.ac.cn 相关论文: 1 Generation of Functional Human Pancreatic beta Cells In Vitro 2 In vivo reprogramming of adult pancreatic exocrine cells to beta-cells 3 The Human Endocrine Pancreas: New Insights on Replacement and Regeneration 4 The use of stem cells for pancreatic regeneration in diabetes mellitus 5 Pancreatic beta Cell Dedifferentiation as a Mechanism of Diabetic beta Cell Failure 6 Conversion of adult pancreatic alpha-cells to beta -cells after extreme beta - cell loss 7 Fasting-Mimicking Diet Promotes Ngn3-Driven beta - Cell Regeneration to Reverse Diabetes
Differentiation of rat iPS cells and ES cells into granulosa cell-like cells in vitro Juan Zhang, Hui Li, Zhao Wu, XiaoJun Tan, Fengying Liu, Xianghong Huang and Xiaoling Fang Acta Biochim Biophys Sin 2013, 45: 289–295; doi: 10.1093/abbs/gmt008 Department of Obstetrics and Gynecology, Second Xiangya Hospital, Central South University, Changsha 410083, China Premature ovarian failure (POF) is an ovarian defect characterized by the premature depletion of ovarian follicles before 40 years of age, representing one major cause of female infertility. Stem cells provide the possibility of a potential treatment for POF. In this study, rat embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) were co-cultured with granulosa cells (GCs) to differentiate to GC-like cells. The level of estradiol (E2) analyzed by radioimmunoassay showed that the E2 concentration of the culture supernatant of co-cultured rat iPSCs and ESCs increased in a time-dependent manner, compared with the GCs group that has an opposite trend. The expression of follicle-stimulating hormone receptor (FSHR) was confirmed by immunostaining. These results indicated that rat iPSCs and ESCs were effectively induced to GC-like cells through indirect cell-to-cell contact. Real-time polymerase chain reaction was performed to analyze the expression level of marker genes in POF, including BMP15, FMR1, FSHR, INHA, AMH, NOBOX, FOXO3, EIF2B, FIGLA, and GDF9. The BMP15, FSHR, INHA, AMH, NOBOX, and GDF9 genes were significantly up-regulated in iPSCs and ESCs co-cultured with GCs in comparison with cells that were not co-cultured. Thus, here we demonstrated an available method to differentiate rat iPSCs and ESCs into GC-like cells in vitro for the possible cell therapy of POF. Expression of FSHR in iPSCs and ESCs co-cultured with GCs 全文: http://abbs.oxfordjournals.org/content/45/4/289.full 相关论文: 1 Ovarian adult stem cells: hope or pitfall? 2 Efficient Differentiation of Steroidogenic and Germ-Like Cells from Epigenetically-Related iPSCs Derived from Ovarian Granulosa Cells 3 Generation of Germ Cells In Vitro in the Era of Induced Pluripotent Stem Cells 4 Efficient Induction of Pluripotent Stem Cells from Granulosa Cells by Oct4 and Sox2 5 Optimal vitrification protocol for mouse ovarian tissue cryopreservation: effect of cryoprotective agents and in vitro culture on vitrifiedwarmed ovarian tissue survival 6 Sex-determining region Y-box 2 and GA-binding proteins regulate the transcription of liver receptor homolog-1 in early embryonic cells 7 EDA-Containing Fibronectin Increases Proliferation of Embryonic Stem Cells
Klf7 modulates the differentiation and proliferation of chicken preadipocyte Zhiwei Zhang, Haixia Wang, Yingning Sun, Hui Li and Ning Wang Key Laboratory of Chicken Genetics and Breeding, Ministry of Agriculture, Harbin 150030, China Acta Biochim Biophys Sin 2013, 45: 280–288; doi: 10.1093/abbs/gmt010 Krüppel-like factor 7 (Klf7) has been extensively studied in the mammalian species, but its function in avian species is unclear. The objective of this study was to reveal the function of chicken Klf7 (Gallus gallus Klf7, gKlf7) in adipogenesis. The results of real-time reverse transcription polymerase chain reaction demonstrated that the relative mRNA level of chicken Klf7 (gKlf7/gβ-Actin) in the abdominal adipose tissue was significantly associated with the abdominal fat content and the age of broilers (P 0.05), and gKlf7 was more highly expressed in preadipocytes than in mature adipocytes (P 0.05). In addition, Oil red O staining showed that gKlf7 inhibited chicken preadipocyte differentiation, and MTT assay indicated that gKlf7 overexpression promoted preadipocyte proliferation. Additionally, luciferase assays showed that gKlf7 overexpression suppressed the chicken CCAAT/enhancer-binding protein α (C/ebpα), fatty acid synthase (Fasn), and lipoprotein lipase (Lpl) promoter activities (P 0.05), and gKlf7 knockdown increased the chicken peroxisome proliferator-activated receptor γ (Pparγ), C/ebpα and fatty acid-binding protein 4 (Fabp4) promoter activities (P 0.05). Together, our study demonstrated that chicken Klf7 inhibits preadipocyte differentiation and promotes preadipocyte proliferation. Effects of Klf7-knockdown and Klf7-overexpression on chicken preadipocyte differentiation 全文: http://abbs.oxfordjournals.org/content/45/4/280.full.pdf+html 相关论文: 1 MiR-146b is a regulator of human visceral preadipocyte proliferation and differentiation and its expression is altered in human obesity 2 Luna, a Drosophila KLF6/ KLF7 , Is Maternally Required for Synchronized Nuclear and Centrosome Cycles in the Preblastoderm Embryo 3 Kruppel -like factor 7 overexpression suppresses hematopoietic stem and progenitor cell function Kruppel -like Factor 7 engineered for transcriptional activation promotes axon regeneration in the adult corticospinal tract 4 Kruppel -like Factor 11 Differentially Couples to Histone Acetyltransferase and Histone Methyltransferase Chromatin Remodeling Pathways to Transcriptionally Regulate Dopamine D2 Receptor in Neuronal Cells 5 Kruppel -like transcription factors in the nervous system: Novel players in neurite outgrowth and axon regeneration
CELL DEATH AND DIFFERENTIATION January 2011 Volume 18 Number 1, pp 1 - 190 ---------------------------------------------------------------------- Cell Death Differentiation: providing over 15 years of research on molecular mechanisms of apoptosis and non-apoptotic forms of cell death. Authors receive an average first decision of 16 working days. View the complete Guide to Authors to learn about preparing your manuscript for submission at http://links.ealert.nature.com/ctt?kn=86m=36080402r=Mzg0ODUxNzczNgS2b=2j=ODk2MTEwNjMS1mt=1rt=0 ---------------------- EDITORIALS ---------------------- CDD comes of age http://links.ealert.nature.com/ctt?kn=33m=36080402r=Mzg0ODUxNzczNgS2b=2j=ODk2MTEwNjMS1mt=1rt=0 c-Abl tyrosine kinase in the DNA damage response: cell death and more V Meltser, M Ben-Yehoyada and Y Shaul http://links.ealert.nature.com/ctt?kn=29m=36080402r=Mzg0ODUxNzczNgS2b=2j=ODk2MTEwNjMS1mt=1rt=0 ---------------------- ORIGINAL PAPERS ---------------------- A positive role for c-Abl in Atm and Atr activation in DNA damage response X Wang, L Zeng, J Wang, J F L Chau, K P Lai, D Jia, A Poonepalli, M P Hande, H Liu, G He, L He and B Li Abstract: http://links.ealert.nature.com/ctt?kn=48m=36080402r=Mzg0ODUxNzczNgS2b=2j=ODk2MTEwNjMS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=46m=36080402r=Mzg0ODUxNzczNgS2b=2j=ODk2MTEwNjMS1mt=1rt=0 Involvement of NF- B/miR-448 regulatory feedback loop in chemotherapy-induced epithelial-mesenchymal transition of breast cancer cells Q-Q Li, Z-Q Chen, X-X Cao, J-D Xu, J-W Xu, Y-Y Chen, W-J Wang, Q Chen, F Tang, X-P Liu and Z-D Xu Abstract: http://links.ealert.nature.com/ctt?kn=40m=36080402r=Mzg0ODUxNzczNgS2b=2j=ODk2MTEwNjMS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=37m=36080402r=Mzg0ODUxNzczNgS2b=2j=ODk2MTEwNjMS1mt=1rt=0 zVAD-induced necroptosis in L929 cells depends on autocrine production of TNF mediated by the PKC-MAPKs-AP-1 pathway Y-T Wu, H-L Tan, Q Huang, X-J Sun, X Zhu and H-M Shen Abstract: http://links.ealert.nature.com/ctt?kn=52m=36080402r=Mzg0ODUxNzczNgS2b=2j=ODk2MTEwNjMS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=50m=36080402r=Mzg0ODUxNzczNgS2b=2j=ODk2MTEwNjMS1mt=1rt=0 Bcl-2 proteins regulate ER membrane permeability to luminal proteins during ER stress-induced apoptosis X Wang, K E Olberding, C White and C Li Abstract: http://links.ealert.nature.com/ctt?kn=83m=36080402r=Mzg0ODUxNzczNgS2b=2j=ODk2MTEwNjMS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=13m=36080402r=Mzg0ODUxNzczNgS2b=2j=ODk2MTEwNjMS1mt=1rt=0 Local insulin-like growth factor I expression is essential for Purkinje neuron survival at birth L Croci, V Barili, D Chia, L Massimino, R van Vugt, G Masserdotti, R Longhi, P Rotwein and G G Consalez Abstract: http://links.ealert.nature.com/ctt?kn=12m=36080402r=Mzg0ODUxNzczNgS2b=2j=ODk2MTEwNjMS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=10m=36080402r=Mzg0ODUxNzczNgS2b=2j=ODk2MTEwNjMS1mt=1rt=0 A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2-Beclin1 interaction at endoplasmic reticulum J Lian, X Wu, F He, D Karnak, W Tang, Y Meng, D Xiang, M Ji, T S Lawrence and L Xu Abstract: http://links.ealert.nature.com/ctt?kn=8m=36080402r=Mzg0ODUxNzczNgS2b=2j=ODk2MTEwNjMS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=6m=36080402r=Mzg0ODUxNzczNgS2b=2j=ODk2MTEwNjMS1mt=1rt=0 SIRT1 stabilizes PML promoting its sumoylation M Campagna, D Herranz, M A Garcia, L Marcos-Villar, J Gonzalez-Santamaria, P Gallego, S Gutierrez, M Collado, M Serrano, M Esteban and C Rivas Abstract: http://links.ealert.nature.com/ctt?kn=4m=36080402r=Mzg0ODUxNzczNgS2b=2j=ODk2MTEwNjMS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=3m=36080402r=Mzg0ODUxNzczNgS2b=2j=ODk2MTEwNjMS1mt=1rt=0 Blebbing confers resistance against cell lysis E B Babiychuk, K Monastyrskaya, S Potez and A Draeger Abstract: http://links.ealert.nature.com/ctt?kn=1m=36080402r=Mzg0ODUxNzczNgS2b=2j=ODk2MTEwNjMS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=16m=36080402r=Mzg0ODUxNzczNgS2b=2j=ODk2MTEwNjMS1mt=1rt=0 Enzymatically active single chain caspase-8 maintains T-cell survival during clonal expansion S Leverrier, G S Salvesen and C M Walsh Abstract: http://links.ealert.nature.com/ctt?kn=20m=36080402r=Mzg0ODUxNzczNgS2b=2j=ODk2MTEwNjMS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=22m=36080402r=Mzg0ODUxNzczNgS2b=2j=ODk2MTEwNjMS1mt=1rt=0 Sustained calcium signalling and caspase-3 activation involve NMDA receptors in thymocytes in contact with dendritic cells P Affaticati, O Mignen, F Jambou, M-C Potier, I Klingel-Schmitt, J Degrouard, S Peineau, E Gouadon, G L Collingridge, R Liblau, T Capiod and S Cohen-Kaminsky Abstract: http://links.ealert.nature.com/ctt?kn=39m=36080402r=Mzg0ODUxNzczNgS2b=2j=ODk2MTEwNjMS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=36m=36080402r=Mzg0ODUxNzczNgS2b=2j=ODk2MTEwNjMS1mt=1rt=0 Ciglitazone negatively regulates CXCL1 signaling through MITF to suppress melanoma growth T Botton, A Puissant, Y Cheli, T Tomic, S Giuliano, L Fajas, M Deckert, J-P Ortonne, C Bertolotto, S Tartare-Deckert, R Ballotti and S Rocchi Abstract: http://links.ealert.nature.com/ctt?kn=47m=36080402r=Mzg0ODUxNzczNgS2b=2j=ODk2MTEwNjMS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=42m=36080402r=Mzg0ODUxNzczNgS2b=2j=ODk2MTEwNjMS1mt=1rt=0 E2F-1 regulation by an unusual DNA damage-responsive DP partner subunit L Ingram, S Munro, A S Coutts and N B La Thangue Abstract: http://links.ealert.nature.com/ctt?kn=30m=36080402r=Mzg0ODUxNzczNgS2b=2j=ODk2MTEwNjMS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=28m=36080402r=Mzg0ODUxNzczNgS2b=2j=ODk2MTEwNjMS1mt=1rt=0 The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis Y J Kang, M-K Lu and K-L Guan Abstract: http://links.ealert.nature.com/ctt?kn=35m=36080402r=Mzg0ODUxNzczNgS2b=2j=ODk2MTEwNjMS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=32m=36080402r=Mzg0ODUxNzczNgS2b=2j=ODk2MTEwNjMS1mt=1rt=0 Doxorubicin bypasses the cytoprotective effects of eIF2 phosphorylation and promotes PKR-mediated cell death P Peidis, A I Papadakis, H Muaddi, S Richard and A E Koromilas Abstract: http://links.ealert.nature.com/ctt?kn=58m=36080402r=Mzg0ODUxNzczNgS2b=2j=ODk2MTEwNjMS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=59m=36080402r=Mzg0ODUxNzczNgS2b=2j=ODk2MTEwNjMS1mt=1rt=0 Enhanced contact allergen- and UVB-induced keratinocyte apoptosis in the absence of CD95/Fas/Apo-1 A Hedrych-Ozimina, K Behrendt, Z Hao, R Pofahl, D Ussath, R Knaup, T Krieg and I Haase Abstract: http://links.ealert.nature.com/ctt?kn=61m=36080402r=Mzg0ODUxNzczNgS2b=2j=ODk2MTEwNjMS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=68m=36080402r=Mzg0ODUxNzczNgS2b=2j=ODk2MTEwNjMS1mt=1rt=0 Maximal adamantyl-substituted retinoid-related molecule-induced apoptosis requires NF- B noncanonical and canonical pathway activation L Farhana, M I Dawson, F Murshed and J A Fontana Abstract: http://links.ealert.nature.com/ctt?kn=67m=36080402r=Mzg0ODUxNzczNgS2b=2j=ODk2MTEwNjMS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=66m=36080402r=Mzg0ODUxNzczNgS2b=2j=ODk2MTEwNjMS1mt=1rt=0 Very low oxygen concentration (0.1%) reveals two FDCP-Mix cell subpopulations that differ by their cell cycling, differentiation and p27KIP1 expression A V Guitart, C Debeissat, F Hermitte, A Villacreces, Z Ivanovic, H Boeuf and V Praloran Abstract: http://links.ealert.nature.com/ctt?kn=65m=36080402r=Mzg0ODUxNzczNgS2b=2j=ODk2MTEwNjMS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=71m=36080402r=Mzg0ODUxNzczNgS2b=2j=ODk2MTEwNjMS1mt=1rt=0 Glucocorticoid-induced activation of caspase-8 protects the glucocorticoid-induced protein Gilz from proteasomal degradation and induces its binding to SUMO-1 in murine thymocytes D V Delfino, S Spinicelli, N Pozzesi, S Pierangeli, E Velardi, S Bruscoli, M P Martelli, V Pettirossi, L Falchi, T-b Kang and C Riccardi Abstract: http://links.ealert.nature.com/ctt?kn=70m=36080402r=Mzg0ODUxNzczNgS2b=2j=ODk2MTEwNjMS1mt=1rt=0 Article: 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CELL DEATH AND DIFFERENTIATION December 2010 Volume 17 Number 12, pp 1805 - 1944 ---------------------------------------------------------------------- Special Issues: an in-depth look into cell death. Cell Death Differentiation publishes a select number of special issu es that include reviews dedicated to the understanding of specific are as in cell death. Special issues of 2010 include: The Ubiquitin Protea some System, MicroRNAs Meet Cell Death, Granzymes in Health and Diseas e, and Cell Death in Yeast. Each special issue offers a select number of Reviews free. Get the latest special issue online at http://links.ealert.nature.com/ctt?kn=18m=35988183r=Mzg0ODUxNzczNgS2b=2j=ODY4NjY0NzgS1mt=1rt=0 ---------------------- EDITORIAL ---------------------- Policy and procedures on scientific misconduct G Melino on behalf of the Editorial Board http://links.ealert.nature.com/ctt?kn=32m=35988183r=Mzg0ODUxNzczNgS2b=2j=ODY4NjY0NzgS1mt=1rt=0 ---------------------- REVIEW ---------------------- Negative regulation of autophagy C Liang Abstract: http://links.ealert.nature.com/ctt?kn=31m=35988183r=Mzg0ODUxNzczNgS2b=2j=ODY4NjY0NzgS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=29m=35988183r=Mzg0ODUxNzczNgS2b=2j=ODY4NjY0NzgS1mt=1rt=0 ---------------------- ORIGINAL PAPERS ---------------------- p73 is an essential regulator of neural stem cell maintenance in embryonal and adult CNS neurogenesis F Talos, A Abraham, A V Vaseva, L Holembowski, S E Tsirka, A Scheel, D Bode, M Dobbelstein, W Bruck and U M Moll Abstract: http://links.ealert.nature.com/ctt?kn=43m=35988183r=Mzg0ODUxNzczNgS2b=2j=ODY4NjY0NzgS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=41m=35988183r=Mzg0ODUxNzczNgS2b=2j=ODY4NjY0NzgS1mt=1rt=0 Novel anti-apoptotic mechanism of A20 through targeting ASK1 to suppress TNF-induced JNK activation M Won, K A Park, H S Byun, K-C Sohn, Y-R Kim, J Jeon, J H Hong, J Park, J H Seok, J M Kim, W-H Yoon, I-S Jang, H M Shen, Z G Liu and G M Hur Abstract: http://links.ealert.nature.com/ctt?kn=37m=35988183r=Mzg0ODUxNzczNgS2b=2j=ODY4NjY0NzgS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=35m=35988183r=Mzg0ODUxNzczNgS2b=2j=ODY4NjY0NzgS1mt=1rt=0 p22phox-dependent NADPH oxidase activity is required for megakaryocytic differentiation J L Sardina, G Lopez-Ruano, L I Sanchez-Abarca, J A Perez-Simon, A Gaztelumendi, C Trigueros, M Llanillo, J Sanchez-Yague and A Hernandez -Hernandez Abstract: http://links.ealert.nature.com/ctt?kn=47m=35988183r=Mzg0ODUxNzczNgS2b=2j=ODY4NjY0NzgS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=45m=35988183r=Mzg0ODUxNzczNgS2b=2j=ODY4NjY0NzgS1mt=1rt=0 Calcium signalling-dependent mitochondrial dysfunction and bioenergetics regulation in respiratory chain Complex II deficiency E Mbaya, B Oules, C Caspersen, R Tacine, H Massinet, M Pennuto, D Chretien, A Munnich, A Rotig, R Rizzuto, G A Rutter, P Paterlini-Brechot and M Chami Abstract: http://links.ealert.nature.com/ctt?kn=75m=35988183r=Mzg0ODUxNzczNgS2b=2j=ODY4NjY0NzgS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=13m=35988183r=Mzg0ODUxNzczNgS2b=2j=ODY4NjY0NzgS1mt=1rt=0 Arsenic trioxide induces a beclin-1-independent autophagic pathway via modulation of SnoN/SkiL expression in ovarian carcinoma cells D M Smith, S Patel, F Raffoul, E Haller, G B Mills and M Nanjundan Abstract: http://links.ealert.nature.com/ctt?kn=11m=35988183r=Mzg0ODUxNzczNgS2b=2j=ODY4NjY0NzgS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=10m=35988183r=Mzg0ODUxNzczNgS2b=2j=ODY4NjY0NzgS1mt=1rt=0 Induction of EMT-like phenotypes by an active metabolite of leflunomide and its contribution to pulmonary fibrosis T Namba, K-I Tanaka, Y Ito, T Hoshino, M Matoyama, N Yamakawa, Y Isohama, A Azuma and T Mizushima Abstract: http://links.ealert.nature.com/ctt?kn=8m=35988183r=Mzg0ODUxNzczNgS2b=2j=ODY4NjY0NzgS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=7m=35988183r=Mzg0ODUxNzczNgS2b=2j=ODY4NjY0NzgS1mt=1rt=0 The p63 target HBP1 is required for skin differentiation and stratification S Borrelli, E Candi, B Hu, D Dolfini, M Ravo, O M V Grober, A Weisz, G P Dotto, G Melino, M A Vigano and R Mantovani Abstract: http://links.ealert.nature.com/ctt?kn=5m=35988183r=Mzg0ODUxNzczNgS2b=2j=ODY4NjY0NzgS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=4m=35988183r=Mzg0ODUxNzczNgS2b=2j=ODY4NjY0NzgS1mt=1rt=0 c-FLIPL enhances anti-apoptotic Akt functions by modulation of Gsk3 activity C Quintavalle, M Incoronato, L Puca, M Acunzo, C Zanca, G Romano, M Garofalo, M Iaboni, C M Croce and G Condorelli Abstract: http://links.ealert.nature.com/ctt?kn=1m=35988183r=Mzg0ODUxNzczNgS2b=2j=ODY4NjY0NzgS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=19m=35988183r=Mzg0ODUxNzczNgS2b=2j=ODY4NjY0NzgS1mt=1rt=0 IL-34 and M-CSF share the receptor Fms but are not identical in biological activity and signal activation T Chihara, S Suzu, R Hassan, N Chutiwitoonchai, M Hiyoshi, K Motoyoshi, F Kimura and S Okada Abstract: http://links.ealert.nature.com/ctt?kn=23m=35988183r=Mzg0ODUxNzczNgS2b=2j=ODY4NjY0NzgS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=24m=35988183r=Mzg0ODUxNzczNgS2b=2j=ODY4NjY0NzgS1mt=1rt=0 Trim17, a novel E3 ubiquitin-ligase, initiates neuronal apoptosis I Lassot, I Robbins, M Kristiansen, R Rahmeh, F Jaudon, M M Magiera, S Mora, L Vanhille, A Lipkin, B Pettmann, J Ham and S Desagher Abstract: http://links.ealert.nature.com/ctt?kn=36m=35988183r=Mzg0ODUxNzczNgS2b=2j=ODY4NjY0NzgS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=34m=35988183r=Mzg0ODUxNzczNgS2b=2j=ODY4NjY0NzgS1mt=1rt=0 ---------------------- CORRESPONDENCE ---------------------- Cyclophilin A release as a biomarker of necrotic cell death D E Christofferson and J Yuan http://links.ealert.nature.com/ctt?kn=38m=35988183r=Mzg0ODUxNzczNgS2b=2j=ODY4NjY0NzgS1mt=1rt=0 ---------------------- RETRACTION ---------------------- Retraction: A novel function of poly(ADP-ribose) polymerase-1 in modulation of autophagy and necrosis under oxidative stress Q Huang, Y-T Wu, H-L Tan, C-N Ong and H-M Shen http://links.ealert.nature.com/ctt?kn=28m=35988183r=Mzg0ODUxNzczNgS2b=2j=ODY4NjY0NzgS1mt=1rt=0 ---------------------------------------------------------------------- Ensure your access If you are unable to access the articles in this Ta ble of Contents e-alert, your library may not subscribe to this journa l. 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CELL DEATH AND DIFFERENTIATION October 2010 Volume 17 Number 10, pp 1525 - 1664 --------------------------------------------------------------------- Nature Publishing Group Language Editing http://links.ealert.nature.com/ctt?kn=3m=35783948r=Mzg0ODUxNzczNgS2b=2j=ODE3NjY4MTcS1mt=1rt=0 NPG Language Editing is a high-quality English language editing service for authors submitting papers for publication in scientific and medical journals. Our focus is on improving the clarity and sense of the written manuscript, so that your research results stand out. Visit NPG Language Editing online to see how you can benefit from our expertise. http://links.ealert.nature.com/ctt?kn=3m=35783948r=Mzg0ODUxNzczNgS2b=2j=ODE3NjY4MTcS1mt=1rt=0 --------------------------------------------------------------------- ---------------------- EDITORIAL ---------------------- A human mitochondriopathy caused by AIF mutation N Modjtahedi, F Giordanetto and G Kroemer http://links.ealert.nature.com/ctt?kn=30m=35783948r=Mzg0ODUxNzczNgS2b=2j=ODE3NjY4MTcS1mt=1rt=0 ---------------------- ORIGINAL PAPERS ---------------------- Cathepsin B facilitates autophagy-mediated apoptosis in SPARC overexpressed primitive neuroectodermal tumor cells P Bhoopathi, C Chetty, M Gujrati, D H Dinh, J S Rao and S Lakka Abstract: http://links.ealert.nature.com/ctt?kn=29m=35783948r=Mzg0ODUxNzczNgS2b=2j=ODE3NjY4MTcS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=28m=35783948r=Mzg0ODUxNzczNgS2b=2j=ODE3NjY4MTcS1mt=1rt=0 Activated macrophages utilize glycolytic ATP to maintain mitochondrial membrane potential and prevent apoptotic cell death A Garedew, S O Henderson and S Moncada Abstract: http://links.ealert.nature.com/ctt?kn=43m=35783948r=Mzg0ODUxNzczNgS2b=2j=ODE3NjY4MTcS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=40m=35783948r=Mzg0ODUxNzczNgS2b=2j=ODE3NjY4MTcS1mt=1rt=0 Cytoplasmic polyadenylation element binding protein is a conserved target of tumor suppressor HRPT2/CDC73 J-H Zhang, L M Panicker, E M Seigneur, L Lin, C D House, W Morgan, W C Chen, H Mehta, M Haj-Ali, Z-X Yu and W F Simonds Abstract: http://links.ealert.nature.com/ctt?kn=35m=35783948r=Mzg0ODUxNzczNgS2b=2j=ODE3NjY4MTcS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=33m=35783948r=Mzg0ODUxNzczNgS2b=2j=ODE3NjY4MTcS1mt=1rt=0 CAML regulates Bim-dependent thymocyte death C E Edgar, L D Lindquist, D L McKean, A Strasser and R J Bram Abstract: http://links.ealert.nature.com/ctt?kn=48m=35783948r=Mzg0ODUxNzczNgS2b=2j=ODE3NjY4MTcS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=46m=35783948r=Mzg0ODUxNzczNgS2b=2j=ODE3NjY4MTcS1mt=1rt=0 Neurodegeneration by polyglutamine Atrophin is not rescued by induction of autophagy I Nisoli, J P Chauvin, F Napoletano, P Calamita, V Zanin, M Fanto and B Charroux Abstract: http://links.ealert.nature.com/ctt?kn=65m=35783948r=Mzg0ODUxNzczNgS2b=2j=ODE3NjY4MTcS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=14m=35783948r=Mzg0ODUxNzczNgS2b=2j=ODE3NjY4MTcS1mt=1rt=0 The cleavage of HuR interferes with its transportin-2-mediated nuclear import and promotes muscle fiber formation P Beauchamp, C Nassif, S Hillock, K van der Giessen, C von Roretz, B J Jasmin and I-E Gallouzi Abstract: http://links.ealert.nature.com/ctt?kn=12m=35783948r=Mzg0ODUxNzczNgS2b=2j=ODE3NjY4MTcS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=11m=35783948r=Mzg0ODUxNzczNgS2b=2j=ODE3NjY4MTcS1mt=1rt=0 Antagonistic roles of Notch and p63 in controlling mammary epithelial cell fates O Yalcin-Ozuysal, M Fiche, M Guitierrez, K-U Wagner, W Raffoul and C Brisken Abstract: http://links.ealert.nature.com/ctt?kn=8m=35783948r=Mzg0ODUxNzczNgS2b=2j=ODE3NjY4MTcS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=7m=35783948r=Mzg0ODUxNzczNgS2b=2j=ODE3NjY4MTcS1mt=1rt=0 Smac/DIABLO release from mitochondria and XIAP inhibition are essential to limit clonogenicity of Type I tumor cells after TRAIL receptor stimulation C Maas, I Verbrugge, E de Vries, G Savich, L W van de Kooij, S W G Tait and J Borst Abstract: http://links.ealert.nature.com/ctt?kn=5m=35783948r=Mzg0ODUxNzczNgS2b=2j=ODE3NjY4MTcS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=4m=35783948r=Mzg0ODUxNzczNgS2b=2j=ODE3NjY4MTcS1mt=1rt=0 Displacement of Bim by Bmf and Puma rather than increase in Bim level mediates paclitaxel-induced apoptosis in breast cancer cells O Kutuk and A Letai Abstract: http://links.ealert.nature.com/ctt?kn=1m=35783948r=Mzg0ODUxNzczNgS2b=2j=ODE3NjY4MTcS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=18m=35783948r=Mzg0ODUxNzczNgS2b=2j=ODE3NjY4MTcS1mt=1rt=0 Ultrastructural and transcriptional profiling of neuropathological misregulation of CREB function L M Valor, D Jancic, R Lujan and A Barco Abstract: http://links.ealert.nature.com/ctt?kn=21m=35783948r=Mzg0ODUxNzczNgS2b=2j=ODE3NjY4MTcS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=22m=35783948r=Mzg0ODUxNzczNgS2b=2j=ODE3NjY4MTcS1mt=1rt=0 Smac mimetics increase cancer cell response to chemotherapeutics in a TNF- -dependent manner B L Probst, L Liu, V Ramesh, L Li, H Sun, J D Minna and L Wang Abstract: http://links.ealert.nature.com/ctt?kn=34m=35783948r=Mzg0ODUxNzczNgS2b=2j=ODE3NjY4MTcS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=32m=35783948r=Mzg0ODUxNzczNgS2b=2j=ODE3NjY4MTcS1mt=1rt=0 Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development P N Kelly, M J White, M W Goschnick, K A Fairfax, D M Tarlinton, S A Kinkel, P Bouillet, J M Adams, B T Kile and A Strasser Abstract: http://links.ealert.nature.com/ctt?kn=42m=35783948r=Mzg0ODUxNzczNgS2b=2j=ODE3NjY4MTcS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=37m=35783948r=Mzg0ODUxNzczNgS2b=2j=ODE3NjY4MTcS1mt=1rt=0 --------------------------------------------------------------------- Ensure your access If you are unable to access the articles in this Table of Contents e-alert, your library may not subscribe to this journal. 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标签: differentiation
