文献分析结果 http://www.gopubmed.org/web/gopubmed/1?WEB01nxdoqonc0a1wIrI9I00h001000j100200010 Kashin-Beck disease and gene 2,068 of 2,074 documents semantically analyzed top author statistics Term: Knowledge Base Root Pathes: 1 2 Top Years Publications 2009 215 2007 212 2008 204 2006 190 2005 157 2004 144 2010 122 2002 119 2001 116 2003 113 2000 90 1999 78 1998 56 1997 53 1995 36 1996 31 1993 27 1994 23 1992 19 1991 19 1 2 1 2 3 Top Countries Publications USA 550 Japan 231 United Kingdom 222 Germany 216 Canada 136 China 84 France 70 Netherlands 64 Spain 47 Australia 43 South Korea 41 Finland 41 Switzerland 38 Italy 34 Taiwan 26 Belgium 24 Sweden 19 Greece 18 Israel 8 Mexico 8 1 2 3 1 2 3 ... 20 Top Cities Publications Montreal 80 Tokyo 75 London 53 Boston 50 Philadelphia 47 San Diego 36 Erlangen 31 Oxford 29 New York 29 Manchester 28 Zrich 27 Leiden 27 Seoul 25 Paris 22 Madrid 21 Cleveland 21 Berlin 20 Regensburg 19 Rotterdam 19 Beijing 19 1 2 3 ... 20 1 2 3 ... 26 Top Journals Publications Arth Rheum/ar C Res 261 Osteoarthr Cartilage 130 Arthritis Res Ther 97 J Rheumatol 88 Ann Rheum Dis 76 Osteoarthritis Cartilage 45 J Immunol 34 J Biol Chem 32 Clin Orthop Relat R 28 Clin Exp Rheumatol 25 Biochem Bioph Res Co 25 Rheumatol Int 23 J Orthop Res 23 Curr Opin Rheumatol 22 Rheumatology 19 J Orthopaed Res 19 Am J Pathol 17 J Bone Miner Res 15 Matrix Biol 14 J Clin Invest 14 1 2 3 ... 26 1 2 3 ... 352 Top Terms Publications Osteoarthritis 1,976 Humans 1,651 Genes 1,580 Cartilage 1,047 Proteins 847 Gene Expression 818 Patients 777 Chondrocytes 739 Tissues 703 Cartilage, Articular 691 Animals 687 RNA, Messenger 668 Middle Aged 636 gene expression 622 Aged 609 Arthritis 600 regulation of gene expression 582 Arthritis, Rheumatoid 521 Cells, Cultured 508 Synovial Membrane 477 1 2 3 ... 352 1 2 3 ... 450 Top Authors Publications Pelletier J 56 Aigner T 52 Martel-Pelletier J 51 Gay S 36 Loughlin J 35 Ikegawa S 26 Evans C 24 Firestein G 24 Spector T 22 Gay R 21 Prockop D 20 Chapman K 19 Tardif G 19 Slagboom P 17 Robbins P 17 Boyle D 17 Di Battista J 17 Ghivizzani S 17 Moskowitz R 17 Doherty M 15 1 2 3 ... 450 最新研究进展 Arthritis Rheum. 2010 Mar;62(3):771-80. Comparative analysis of gene expression profiles between primary knee osteoarthritis and an osteoarthritis endemic to Northwestern China, Kashin-Beck disease. Duan C , Guo X , Zhang XD , Yu HJ , Yan H , Gao Y , Ma WJ , Gao ZQ , Xu P , Lammi M . Medical College of Xi'an Jiaotong University, Number 76 Yan Ta, West Road, Xi'an, Shaanxi 710061, China. Abstract OBJECTIVE: To investigate the differences in gene expression profiles of adult articular cartilage from patients with Kashin-Beck disease (KBD) versus those with primary knee osteoarthritis (OA). METHODS: The messenger RNA expression profiles of articular cartilage from patients with KBD, diagnosed according to the clinical criteria for KBD in China, were compared with those of cartilage from patients with OA, diagnosed according to the Western Ontario and McMaster Universities OA Index. Total RNA was isolated separately from 4 pairs of the KBD and OA cartilage samples, and the expression profiles were evaluated by Agilent 4x44k Whole Human Genome density oligonucleotide microarray analysis. The microarray data for selected transcripts were confirmed by quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR) amplification. RESULTS: For 1.2 x 10(4) transcripts, corresponding to 58.4% of the expressed transcripts, 2-fold changes in differential expression were revealed. Expression levels higher in KBD than in OA samples were observed in a mean + or - SD 6,439 + or - 1,041 (14.6 + or - 2.4%) of the transcripts, and expression levels were lower in KBD than in OA samples in 6,147 + or - 1,222 (14.2 + or - 2.8%) of the transcripts. After application of the selection criteria, 1.85% of the differentially expressed genes (P 0.001 between groups) were detected. These included 233 genes, of which 195 (0.4%) were expressed at higher levels and 38 (0.08%) were expressed at lower levels in KBD than in OA cartilage. Comparisons of the quantitative RT-PCR data supported the validity of our microarray data. CONCLUSION: Differences between KBD and OA cartilage exhibited a similar pattern among all 4 of the pairs examined, indicating the presence of disease mechanisms, mainly chondrocyte matrix metabolism, cartilage degeneration, and apoptosis induction pathways, which contribute to cartilage destruction in KBD. PMID: 20131229 Publication Types, MeSH Terms, Substances Publication Types: Comparative Study Research Support, Non-U.S. Gov't MeSH Terms: China/epidemiology Female Gene Expression* Genome-Wide Association Study Humans Male Microarray Analysis Middle Aged Osteoarthritis/epidemiology* Osteoarthritis/genetics* Osteoarthritis, Knee/genetics* RNA, Messenger/analysis Reverse Transcriptase Polymerase Chain Reaction Substances: RNA, Messenger LinkOut - more resources Full Text Sources: John Wiley Sons, Inc. EBSCO OhioLINK Electronic Journal Center Ovid Technologies, Inc. Swets Information Services Other Literature Sources: Evaluations and comments from leading researchers and clinicians - Faculty of 1000 Medicine Medical: Joint Disorders - MedlinePlus Health Information Osteoarthritis - MedlinePlus Health Information Libraries: LinkOut Holdings Supplemental Content 全文获取 Related citations 相关文献 Comparative analysis of gene expression profiles between the normal human cartilage and the one with endemic osteoarthritis. Comparative analysis of gene expression profiles between the normal human cartilage and the one with endemic osteoarthritis. Wang WZ, Guo X, Duan C, Ma WJ, Zhang YG, Xu P, Gao ZQ, Wang ZF, Yan H, Zhang YF, et al. Osteoarthritis Cartilage. 2009 Jan; 17(1):83-90. Epub 2008 Jun 24. Comparative analysis of gene expression profiles in intact and damaged regions of human osteoarthritic cartilage. Comparative analysis of gene expression profiles in intact and damaged regions of human osteoarthritic cartilage. Sato T, Konomi K, Yamasaki S, Aratani S, Tsuchimochi K, Yokouchi M, Masuko-Hongo K, Yagishita N, Nakamura H, Komiya S, et al. Arthritis Rheum. 2006 Mar; 54(3):808-17. Wang SJ, Guo X, Ren FL, Zhang YG, Zhang ZT, Zhang FJ, Geng D. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2006 Apr; 28(2):267-70. Wang SJ, Guo X, Chen JH, Ren FL, Guo R, Liu JJ, Zhang ZT. Nan Fang Yi Ke Da Xue Xue Bao. 2006 Jul; 26(7):927-30. Subtractive gene expression profiling of articular cartilage and mesenchymal stem cells: serpins as cartilage-relevant differentiation markers. Subtractive gene expression profiling of articular cartilage and mesenchymal stem cells: serpins as cartilage-relevant differentiation markers. Boeuf S, Steck E, Pelttari K, Hennig T, Buneb A, Benz K, Witte D, Sltmann H, Poustka A, Richter W. Osteoarthritis Cartilage. 2008 Jan; 16(1):48-60. Epub 2007 Jul 2. See reviews... See all... 基因信息 http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pcsubstanceDbFrom=pubmedCmd=LinkLinkName=pubmed_pcsubstance_meshIdsFromResult=20131229 1: SID: 85305383 Literature , Other Links messenger RNA; template RNA; mRNA ... Source : ChEBI ( CHEBI:33699 ) http://ww EBI Databases Small Molecules ChEBI Main messenger RNA (CHEBI:33699)
标签: 大骨节病
