从科学网（而不是别的渠道）得知，饶毅教授关于“性取向”的研究成果在Nature上发表。恭喜！ 查看原文，饶毅教授他们在“导言”中，写道： Interactions between members of the opposite sex are essential for sexually reproducing animals. Evolutionary benefits have been proposed for homo- and bisexual traits 1 , 2 , which exist in many animals 2 from American bulls 3 to Japanese rhesus monkeys 4 . Studies of animals with different sexual preferences are essential for understanding the seemingly simple decision of a male to court a female.( http://www.nature.com/nature/journal/vaop/ncurrent/full/nature09822.html ) 该研究得到中国（和美国）财政经费的资助：973，北京市科委，以及NIH(to Z.-F.C.)。 让饶氏科研飞一会儿……；飞到Nature去。 让饶氏论文飞一会儿……；飞到哪里去？ 整篇文章，本人大概只能读懂上述“导言”。 在分子上水平研究性取向的秘密，非常有意思的科学研究，咱公众也很感兴趣。饶毅博士及其课题组能否对该研究科普一下？ 本人知道饶毅教授不仅提倡科学家从事包括科普在内的 社会公益服务，而 且身体力行。《饶议科学》是很好的科普读物，不仅是狭义的“科”普，而且有对科学的社会运行（如实验室、科技政策等）的科普。还记得他去跟小学生上过课（听课的学生中有他的儿子）。 饶毅博士曾说：中国科学家做公益的比较少，乃“一心只读圣贤书”的现代翻版，其实也可以 是自私的一个遁词。 是否可以请像饶毅那样对科普具有社会责任感和义务感的科学家，对其重要科学研究和科学发现，做一点配套科普？（“这样的要求，算不算 太高？”） 另外，本人注意到，该文有一个声明，哪位能解释那是什么意思？ Competing financial interests：The authors declare no competing financial interests. —————————————————————— 血清素与血清神经元可调控哺乳动物性取向 http://news.sciencenet.cn//htmlpaper/201132413551554815733.shtm 虽然雄性如何选择交配对象一直都是社交行为中被重点关注的问题，但科学家还未能从分子和细胞作用机制上解释哺乳动物性取向。 北京大学生命科学学院院长 饶毅 教授课题组通过研究发现，神经递质五羟色胺（5-HT，又称血清素）在哺乳动物性取向中具有重要作用。野生型雄性小鼠的正常性取向为雌性，虽然缺少中枢血清神经元一般不会导致小鼠嗅觉和信息素感应功能出现缺陷，但小鼠的性取向会因此丧失。该研究通过将大脑中5-HT合成过程中首要的色氨酸羟化酶2（Tph2）从小鼠中敲除，以考察5-HT的作用。在实验中，研究人员往小鼠体内注射中间体5-羟基色氨酸（5-HTP）（该物质可在没有Tph2的情况下将5-HT恢复到野生型小鼠的正常水平），35分钟后，Tph2被敲除的小鼠性取向恢复正常。研究人员由此得出结论，在成体大脑中的5-HT和血清神经元对哺乳动物性取向具有调控作用。 该研究于3月23日在线发表在《自然》杂志上。（来源：科学网 张笑/编译） 友情链接：郝炘 ： 也议饶毅小组发的《自然》论文 （谈论文中关于“竞争商业利益”的声明）
血清素与血清神经元可调控哺乳动物性取向 北京大学生命科学学院院长 饶毅 教授课题组通过研究发现，神经递质五羟色胺（5-HT，又称血清素）在哺乳动物性取向中具有重要作用。 http://news.sciencenet.cn//htmlpaper/201132413551554815733.shtm Molecular regulation of sexual preference revealed by genetic studies of 5-HT in the brains of male mice Yan Liu , 1 , 2 , 6 Yun’ai Jiang , 1 , 3 , 6 Yunxia Si , 1 Ji-Young Kim , 4 Zhou-Feng Chen 4 Yi Rao 1 , 5 Affiliations Contributions Corresponding author Journal name: Nature Year published: (2011) DOI: doi:10.1038/nature09822 Received 12 August 2010 Accepted 14 January 2011 Published online 23 March 2011 http://www.nature.com/nature/journal/vaop/ncurrent/abs/nature09822.html 相关研究主题（详细分析报告见附件） 5-HT and sexual preference http://www.gopubmed.org/web/gopubmed/2?WEB1mOWEB10O00d000j10020001000h00100090000 Top Terms Publications Serotonin 722 Animals 626 Sexuality 621 Sexual Behavior, Animal 493 Sexual Behavior 462 Rats 433 Humans 306 Serotonin Uptake Inhibitors 206 Adult 193 Receptors, Serotonin 176 Dopamine 174 Ejaculation 167 Pharmaceutical Preparations 161 Hypothalamus 153 response to fluoxetine 139 Hormones 135 5-hydroxytryptamine receptor 2A 134 Estradiol 134 Brain 134 Norepinephrine 131 1 2 3 ... 174 附件：信息分析报告 sexual preference.docx 知识发现平台 http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi Start A-Literature C-Literature B-list Filter Literature A-query: 5-HT and sexual preference C-query: brains and male mice The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 19 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here . The results of this search are saved under id # 30269 and can be accessed from the start page after you leave this session. There are 190 terms on the current B-list ( 48 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin. To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms. 基因知识发现结果 http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/view_b_txt.cgi?ID=30269 job id # 30269 started Thu Mar 24 02:46:27 2011 Max_citations: 50000 Stoplist: /var/www/html/arrowsmith_uic/data/stopwords_pubmed Ngram_max: 3 30269 Search ARROWSMITH A A_query_raw: 5-HT and sexual preferenceThu Mar 24 02:46:44 2011 A query = 5-HT and sexual preference started Thu Mar 24 02:46:45 2011 A query resulted in 861 titles 30269 Search ARROWSMITH C C_query_raw: brains and male mice Thu Mar 24 02:47:08 2011 C: brains and male mice 43446 A: pubmed_query_A 861 AC: ( 5-HT and sexual preference ) AND ( brains and male mice ) 19 C query = brains and male mice started Thu Mar 24 02:47:10 2011 C query resulted in 43446 titles A AND C query resulted in 19 titles 3398 B-terms ready on Thu Mar 24 02:51:14 2011 Viewed B-terms Thu Mar 24 02:52:25 2011 Sem_filter: Genes Molecular Sequences, and Gene Protein Names 190 B-terms left after filter executed Thu Mar 24 02:55:43 2011 B-list on Thu Mar 24 02:56:48 2011 1 5-ht1a 2 eralpha 3 5-ht3 4 5-ht2a 5 5-ht2c 6 5-ht2 7 5-ht1b 8 estrogen receptor alpha 9 leptin 10 ssri 11 opiate receptor 12 aromatase 13 lhrh 14 gene schizophrenia 15 c fos 16 transgene 17 dopamine receptor 18 pkc 19 tryptophan hydroxylase gene 20 crh 21 trh 22 estrogen receptor 23 thyrotropin releasing hormone 24 5ht1a 25 hedgehog 26 5-ht 27 monoamine oxidase 28 neuropeptide 29 cpp 30 snp 31 fos 32 drd3 33 tryptophan hydroxylase 34 hydroxylase gene 35 dopa 36 maoa 37 epilepsy 38 msh 39 locomotor activity 40 sch 41 g protein 42 2c 43 transporter 44 1d 45 gaba 46 emotionality 47 adhd 48 als 高相关研究主题实例 5-HT and sexual preference 5-ht3 brains and male mice http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/show_sentences.cgi Start A-Literature C-Literature B-list Filter Literature AB literature B-term BC literature 5-HT and sexual preference 5-ht3 brains and male mice 1: 5-HT3 receptors in the ventromedial nucleus of the hypothalamus and female sexual behavior.1997 Add to clipboard 2: Effects of 5-HT3 agonists on reproductive behaviors in rats.1994 Add to clipboard 3: Effects of chlordiazepoxide, buspirone and the 5-HT3 receptor antagonist, BRL 46470, on the behaviour of oestrous and dioestrous female mice when encountering male partners.1993 Add to clipboard 4: Lack of effects of 5-HT3 antagonists on normal and morphine-attenuated sexual behaviours in female and male rats.1993 Add to clipboard 1: From mouse to man: the 5-HT3 receptor modulates physical dependence on opioid narcotics.2009 Add to clipboard 2: Interactions between the anxiogenic effects of CB1 gene disruption and 5-HT3 neurotransmission.2009 Add to clipboard 3: Central 5-HT3 receptor-induced hypothermia in mice: interstrain differences and comparison with hypothermia mediated via 5-HT1A receptor.2009 Add to clipboard 4: Dopamine neurotransmission is involved in the attenuating effects of 5-HT3 receptor antagonist MDL 72222 on acute methamphetamine-induced locomotor hyperactivity in mice.2008 Add to clipboard 5: Anxiolytic-like effect of a serotonergic ligand with high affinity for 5-HT1A, 5-HT2A and 5-HT3 receptors.2005 Add to clipboard 6: Orally active benzoxazole derivative as 5-HT3 receptor partial agonist for treatment of diarrhea-predominant irritable bowel syndrome.2005 Add to clipboard 7: Characterisation of c-Fos expression in the central nervous system of mice following right atrial injections of the 5-HT3 receptor agonist phenylbiguanide.2005 Add to clipboard 8: Benzimidazole derivatives. Part 5: design and synthesis of new benzimidazole-arylpiperazine derivatives acting as mixed 5-HT1A /5-HT3 ligands.2004 Add to clipboard 9: Contribution of P-glycoprotein to efflux of ramosetron, a 5-HT3 receptor antagonist, across the blood-brain barrier.2002 Add to clipboard 10: Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 2. Molecular basis of the intrinsic efficacy of arylpiperazine derivatives at the central 5-HT3 receptors.1999 Add to clipboard 11: Quinolizidinyl derivatives of 2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxylic acid and 1-homolupinanoyl benzimidazolones as ligands for 5-HT3 and 5-HT4 receptors.1999 Add to clipboard 12: Study of mechanisms of calcitonin analgesia in mice. Involvement of 5-HT3 receptors.1999 Add to clipboard 13: Benzoxazole derivatives as novel 5-HT3 receptor partial agonists in the gut.1998 Add to clipboard 14: Novel and highly potent 5-HT3 receptor agonists based on a pyrroloquinoxaline structure.1997 Add to clipboard 15: Synthesis and evaluation of 5-HT3 receptor antagonist KF17643.1996 Add to clipboard 16: Synthesis and 5-HT3 affinity of new 3-substituted indoles at central nervous system.1996 Add to clipboard 17: Synthesis of 5-HT3 receptor antagonists, Y-25130 and YM060.1995 Add to clipboard 18: The pharmacology of VA21B7: an atypical 5-HT3 receptor antagonist with anxiolytic-like properties in animal models.1995 Add to clipboard 19: 5-HT3 receptor antagonism by anpirtoline, a mixed 5-HT1 receptor agonist /5-HT3 receptor antagonist.1995 Add to clipboard 20: Effects of iodoproxyfan, a potent and selective histamine H3 receptor antagonist, on alpha 2 and 5-HT3 receptors.1995 Add to clipboard 21: Antidepressant-like effects of SR 57227A, a 5-HT3 receptor agonist, in rodents.1995 Add to clipboard 22: The 5-HT3 receptor agonist 1-(m-chlorophenyl)-biguanide facilitates noradrenaline release by blockade of alpha 2-adrenoceptors in the mouse brain cortex.1994 Add to clipboard 23: Effects of 5-HT3 receptor antagonists on binding and function of mouse and human GABAA receptors.1994 Add to clipboard 24: A mechanism of 5-HT3 receptor mediation is involved etiologically in the psychological stress lesion the stomach of the mouse.1994 Add to clipboard 25: Intrathecal 5-methoxy-N,N-dimethyltryptamine in mice modulates 5-HT1 and 5-HT3 receptors.1993 Add to clipboard 26: SR 57227A: a potent and selective agonist at central and peripheral 5-HT3 receptors in vitro and in vivo.1993 Add to clipboard 27: Electrophysiological, biochemical and behavioral evidence for 5-HT2 and 5-HT3 mediated control of dopaminergic function.1993 Add to clipboard 28: Different densities of 5-HT3 receptors are labeled by quipazine, GR 65630 and granisetron.1993 Add to clipboard 29: Behavioural studies on WAY100289, a novel 5-HT3 receptor antagonist, in two animal models of anxiety.1992 Add to clipboard 30: Spinal 5-HT3 receptor-mediated antinociception: possible release of GABA.1991 Add to clipboard 31: The differential activities of R (+)- and S(-)-zacopride as 5-HT3 receptor antagonists.1990 Add to clipboard 32: The effects of ondansetron, a 5-HT3 receptor antagonist, on cognition in rodents and primates.1990 Add to clipboard 33: Neuroanatomical sites of action of 5-HT3 receptor agonist and antagonists for alteration of aversive behaviour in the mouse.1989 Add to clipboard 34: Binding of the 5-HT3 ligand, GR65630, to rat area postrema, vagus nerve and the brains of several species.1989 Add to clipboard 35: Localisation by autoradiography of neuronal 5-HT3 receptors in the mouse CNS.1988 Add to clipboard
几年前我们实验室来了一位优雅的珍娜小姐，她为人善良，彬彬有礼。她热爱动物，养了两条狗，五只猫， 甚至不能容忍实验室老鼠流血。我想这是因为她受在霍普金斯大学当教授的父亲的影响。后来听说她要结婚了，我们非常郑重地给她送了一根象征永久相依的绳子，却不知这根绳子要牵的是谁。再后来在年终教授家里的party上，听说她把她的那一半带来了，原来也是一个美眉，让我大跌眼镜。 美国宾州州立大学的戴维.普拉斯（David Plus），在最近一期《行为神经科学杂志》的研究报告中指出，人的手指长度与性取向有密切关系。人的第二与第四指即食指与无名指的比例可以作为衡量早期性激素水平的参照指标。他们还发现，该比例也与男女的性取向有关。他们通过对1618例正常男性和1693例正常女性，1503例男同性恋和1014例女同性恋研究后，指出正常女性性取向的该手指长度比例高于女同性恋组的比例；但是，正常男性性取向组与男同性恋组没有显著差异，这说明男女同性恋可能具有完全不同的神经化学和中枢机制。目前尚不知这项研究在不同族群（如中国人）中的可信度。 这项研究也提示我们，早期监测婴儿的性激素水平意义非凡。通过早期筛选危险人群，及早进行行为干预可以达到预防异常性取向的发生。 对于成人有别于常人的性取向是否应该合法，我无法表达我的意见，因为我对这类人了解太少。坦率的说，第一次在媒体上看见两个同性亲昵的主动，我浑身不自在。好在珍娜小姐表面上与常人无异，自从知道她的这点隐私后不久，她就离开了我们实验室。不过我的一位朋友春，与女同性恋有更近距离的接触，那是完全不同的故事。她受邀参加同性恋派对，亲身经历那些同性恋者之间和谐、默契的亲情。一位有二十年同性恋经历的女性开始把春当成她的一伙，后发现春是异类，坦率向春谈论她二十年的幸福婚姻，并问她，我们从未吵架，你们吵架吗？我了解春是典型的女强人，在家是不折不扣的妻管严。面对这样的问题，她无语。 延伸阅读： Grimbos T , et al.Sexual orientation and the second to fourth finger length ratio: a meta-analysis in men and women. Behav Neurosci. 2010 Apr;124(2):278-87.（ http://content.apa.org/pubmed/bne/124/2/278 ）
标签: 性取向
