科研生涯与学术成就： Peter Barnes Department of Thoracic Medicine, Imperial College School of Medicine, UK http://f1000medicine.com/member/1657146821606700 http://www1.imperial.ac.uk/medicine/people/p.j.barnes/ 主要论著与被引用情况： Nuclear factor-{kappa} B--a pivotal transcription factor in chronic inflammatory diseases endo.gr PJ Barnes , M Karin - The New England journal of medicine, 1997 - endo.gr What causes these diseases is still a mystery, but the disease process results from an interplay of genetic and environmental factors. Genes, such as those for atopy in asthma and for HLA antigens in rheumatoid arthritis and inflammatory bowel disease, may determine a patient's ... Cited by 2851 - Related articles - Cached - BL Direct - All 7 versions Anti-inflammatory actions of steroids: molecular mechanisms portlandpress.com PJ Barnes , I Adcock, M Spedding, PM - Trends in pharmacological , 1993 - Elsevier Glucocorticosteroids are highly effective in controlling inflammation and the molecular mechanisms involved are now becoming clear. Activation of glucocorticoid receptors results in increased or decreased transcription of a number of genes involved in the inflammatory process. Of ... Cited by 1164 - Related articles - BL Direct - All 17 versions Effect of inhaled formoterol and budesonide on exacerbations of asthma nejm.org , AE Tattersfield, P O'Byrne, PJ Barnes , A - England Journal of , 1997 - content.nejm.org Methods After a four-week run-in period of treatment with budesonide (800 g twice daily), 852 patients being treated with glucocorticoids were randomly assigned to one of four treatments given twice daily by means of a dry-powder inhaler (Turbuhaler): 100 g of budesonide ... Cited by 1051 - Related articles - BL Direct - All 14 versions Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response , TT Hansel, ST Holgate, PJ Sterk, PJ Barnes - The Lancet, 2000 - Elsevier Monoclonal antibody against IL-5 lowered the mean blood eosinophil count at day 29 from 025x10 9 /L (95% CI 016-034) in the placebo group to 004x10 9 /L (000-007) in the 10 mg/kg group (p00001), and prevented the blood eosinophilia that follows allergen ... Cited by 947 - Related articles - BL Direct - All 9 versions Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary 171.66.122.149 S Hurd, A Anzueto, PJ Barnes , SA Buist, P - American journal of , 2007 - 171.66.122.149 Chronic obstructive pulmonary disease (COPD) remains a major public health problem. It is the fourth leading cause of chronic morbidity and mortality in the United States, and is projected to rank fifth in 2020 in burden of disease worldwide, according to a study published by the ... Cited by 917 - Related articles - BL Direct - All 26 versions Inflammatory mediators of asthma: an update aspetjournals.org PJ Barnes , KF Chung, CP Page - Pharmacological reviews, 1998 - ASPET Asthma is a complex chronic inflammatory disease of the airways that involves the activation of many inflammatory and structural cells, all of which release inflammatory mediators that result in the typical pathophysiological changes of asthma ( Barnes , 1996a) (table1). By ... Cited by 791 - Related articles - BL Direct - All 10 versions Efficacy and safety of inhaled corticosteroids. New developments atsjournals.org PJ BARNES , S PEDERSEN, WW - American journal of , 1998 - Am Thoracic Soc Inhaled corticosteroids have revolutionized the treatment of asthma and have now become the mainstay of therapy for patients with chronic disease (1). In a supplement to this journal published 5 yr ago the currently available data on efficacy and safety of inhaled corticosteroids was ... Cited by 565 - Related articles - All 7 versions Inhaled glucocorticoids for asthma nejm.org PJ Barnes - New England Journal of Medicine, 1995 - content.nejm.org Glucocorticoids may have direct inhibitory effects on many of the cells involved in airway inflammation in asthma, including macrophages, T-lymphocytes, eosinophils, and airway epithelial cells. 3 In culture, the drugs decrease cytokine-mediated survival of eosinophils by stimulating ... Cited by 536 - Related articles - BL Direct - All 5 versions Exhaled markers of pulmonary disease atsjournals.org SA Kharitonov, PJ Barnes - journal of respiratory and critical care , 2001 - Am Thoracic Soc There has recently been an explosion of interest in the analysis of breath constituents as a way of monitoring inflammation and oxidative stress in the lungs. Here we review the use of exhaled breath analysis in the diagnosis and monitoring of lung disease. Although most studies ... Cited by 527 - Related articles - BL Direct - All 6 versions Low dose inhaled budesonide and formoterol in mild persistent asthma. The OPTIMA randomized trial atsjournals.org O'BYRNE, PJ Barnes , R Rodriguez-Roisin - American journal of , 2001 - Am Thoracic Soc The optimal treatment for mild asthma is uncertain. We assessed the effects of adding a long-acting inhaled beta-agonist, formoterol, to low doses of an inhaled corticosteroid, budesonide, for 1 yr in subjects with mild asthma, receiving no or only a small dose of ... Cited by 474 - Related articles - BL Direct - All 9 versions Effects of inhaled and oral glucocorticoids on inflammatory indices in asthma and COPD , A Jatakanon, YM Worsdell, PJ Barnes - American journal of , 1997 - Am Thoracic Soc The role of glucocorticoids in the treatment of chronic obstructive pulmonary disease (COPD) is controversial. We have previously described high numbers of neutrophils and high concentrations of the inflammatory cytokines interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF- ... Cited by 436 - Related articles - BL Direct - All 4 versions Nitric oxide and asthmatic inflammation PJ Barnes , FY Liew - Immunology today, 1995 - Elsevier Asthmatic patients show an increased expression of inducible nitric oxide synthase (iNOS) in airway epithelial cells and an increased level of nitric oxide (NO) in exhaled air. The NO derived from airway epithelial cells may be a mechanism for amplifying and perpetuating ... Cited by 393 - Related articles - BL Direct - All 5 versions Neutrophilic inflammation in severe persistent asthma 171.66.122.149 Maziak, SAM Lim, KF Chung, PJ Barnes - American journal of , 1999 - 171.66.122.149 Airway inflammation in severe asthma is not well characterized but may involve neutrophils. We have compared induced sputum profiles in patients with asthma of varying severity and normal control subjects. We have also measured exhaled nitric oxide (NO) as a noninvasive ... Cited by 442 - Related articles - BL Direct - All 4 versions Induction of direct antimicrobial activity through mammalian toll-like receptors , M Engele, PA Sieling, PF Barnes , M Rollinghoff, PL - Science, 2001 - sciencemag.org This copy is for your personal, non-commercial use only. ... . clicking here colleagues, clients, or customers by ... , you can order high-quality copies for your ... If you wish to distribute this article to others ... Permission to republish or repurpose articles or portions of articles Cited by 404 - Related articles - BL Direct - All 13 versions New concepts in the pathogenesis of bronchial hyperresponsiveness and asthma* 1 PJ Barnes - Journal of allergy and clinical immunology, 1989 - Elsevier Recent studies have suggested that inflammation may play an important role in the characteristic bronchial hyperresponsiveness and symptoms of chronic asthma. The mechanisms by which inflammatory cells, mediators, and nerves interact to produce the features of asthma are ... Cited by 367 - Related articles - All 5 versions Tuberculosis in patients with human immunodeficiency virus infection nejm.org DV Havlir, PF Barnes - New England Journal of Medicine, 1999 - content.nejm.org Tuberculosis remains an important problem in patients with human immunodeficiency virus (HIV) infection in the United States, with an estimated 6000 to 9000 new cases annually. 1 The case rates are extraordinarily high among indigent patients and substance abusers, and ... Cited by 348 - Related articles - BL Direct - All 9 versions Differential effects of cytolytic T cell subsets on intracellular infection , K Uyemura, S Cho, PF Barnes , JP Rosat, A Sette, MB - Science, 1997 - sciencemag.org This copy is for your personal, non-commercial use only. ... . clicking here colleagues, clients, or customers by ... , you can order high-quality copies for your ... If you wish to distribute this article to others ... Permission to republish or repurpose articles or portions of articles Cited by 367 - Related articles - BL Direct - All 10 versions Exhaled 8-isoprostane as an in vivo biomarker of lung oxidative stress in patients with COPD and healthy smokers atsjournals.org , SA KHARITONOV, PJ BARNES - American journal of , 2000 - Am Thoracic Soc Most of the studies linking chronic obstructive pulmonary disease (COPD) with oxidative stress are in vitro, using invasive techniques, or measuring systemic oxidative stress. The aim of this study was to quantify oxidative stress in the lungs in patients with COPD and in healthy ... Cited by 331 - Related articles - BL Direct - All 4 versions Reactive oxygen species and airway inflammation PJ Barnes - Free Radical Biology and Medicine, 1990 - Elsevier Reactive oxygen species may be generated by several inflammatory cells which participate in airway inflammation and their production may be increased in asthma. Oxygen metabolites may contribute to the epithelial damage which is characteristic of asthmatic airways and may ... Cited by 333 - Related articles - All 3 versions Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic response , JA Bock, MJ Boyce, TT Hansel, ST Holgate, PJ Barnes - The Lancet, 2000 - Elsevier IL-12 caused a significant decrease from baseline in the main peripheral blood eosinophil count 24 h after the fourth injection compared with placebo (p=00001). Sputum eosinophils were also significantly decreased 24 h after allergen challenge when treated with IL-12 compared ... Cited by 322 - Related articles - BL Direct - All 8 versions K Ito, PJ Barnes , IM Adcock - Molecular and Cellular Biology, 2000 - Am Soc Microbiol We have investigated the ability of dexamethasone to regulate interleukin-1 (IL-1 )-induced gene expression, histone acetyltransferase (HAT) and histone deacetylase (HDAC) activity. Low concentrations of dexamethasone (10 10 M) repress IL-1 -stimulated granulocyte-macrophage colony- ... Cited by 345 - Related articles - BL Direct - All 6 versions Increased 8-isoprostane, a marker of oxidative stress, in exhaled condensate of asthma patients 171.66.122.149 , J Nightingale, SA Kharitonov, PJ Barnes - American journal of , 1999 - 171.66.122.149 Oxidative stress has an important role in the pathogenesis of asthma. 8-Isoprostane is a prostaglandin (PG)-F 2 -like compound belonging to the F 2 isoprostane class that is produced in vivo by the free radical-catalyzed peroxidation of arachidonic acid. 8-Isoprostane is a biomarker of ... Cited by 307 - Related articles - BL Direct - All 5 versions Evidence for Involvement of NF- B in the Transcriptional Control of COX-2 Gene Expression by IL-1 * 1 Kuitert, M Bergmann, IM Adcock, PJ Barnes - Biochemical and , 1997 - Elsevier The cyclooxygenase (COX) isoforms COX-1 and COX-2 convert arachidonic acid to prostaglandin (PG) precursors and are a limiting step in PG production. Interleukin-1 (IL-1) treatment of type II A549 cells increases PGE 2 synthesis via transcription- and translation-dependent ... Cited by 276 - Related articles - BL Direct - All 6 versions Nitric oxide is the endogenous neurotransmitter of bronchodilator nerves in humans Belvisi, C David Stretton, M Yacoub, PJ Barnes - European journal of , 1992 - Elsevier European Journal of Pharmacology, 210 (1992) 221-222 C 1992 Elsevier Science Publishers BV All rights reserved 0014-2999/92/$05.00 EJP 03328 Rapid communication Nitric oxide is the endogenous neurotransmitter of bronchodilator nerves in humans Maria G. Belvisi, C. ... Cited by 262 - Related articles - All 4 versions Nitric oxide and lung disease. bmj.com PJ Barnes , MG Belvisi - Thorax, 1993 - thorax.bmj.com Even five years ago few could have realised that the simple gas nitric oxide (NO) would be involved in the regulation of so many physiological functions and pathophysiologi- cal processes. There has been an explosion of information about nitric oxide which appears to be involved in ... Cited by 311 - Related articles - BL Direct - All 8 versions Decreased histone deacetylase activity in chronic obstructive pulmonary disease nejm.org Hayashi, IM Adcock, JC Hogg, PJ Barnes - England Journal of , 2005 - content.nejm.org From the Airway Disease Section, National Heart and Lung Institute, Imperial College, London (KI, MI, BC, OMK, IMA, PJB); the Chest and Allergy Clinic, St. Mary's Hospital, London (OMK); Uni- versity of British Columbia and the James Hogg iCAPTURE Center for ... Cited by 332 - Related articles - All 11 versions Increased formation of the potent oxidant peroxynitrite in the airways of asthmatic patients is associated with induction of nitric oxide synthase: effect of inhaled fasebj.org D Saleh, P Ernst, S Lim, PJ Barnes , A Giaid - The FASEB Journal, 1998 - FASEB THE AIRWAY EPITHELIUM is exposed to various exogenous and endogenous oxidants that influence its function and structure (1). Endogenous oxidants are produced by the reaction of local free radicals and intracellular reactive oxygen species, and often lead to extensive ... Cited by 303 - Related articles - BL Direct - All 5 versions Granulocyte activation markers in induced sputum: comparison between chronic obstructive pulmonary disease, asthma, and normal subjects VM Keatings, PJ Barnes - journal of respiratory and critical care , 1997 - 171.66.122.149 Airway inflammation is present in asthma and is thought to play a significant part in the development of airflow obstruction. In chronic obstructive pulmonary disease (COPD), neutrophilic inflammation is present in the airway lumen, whereas the submucosa displays a lymphocytic infiltrate. ... Cited by 279 - Related articles - BL Direct - All 4 versions Effect of high dose inhaled steroid on cells, cytokines, and proteases in induced sputum in chronic obstructive pulmonary disease atsjournals.org , JL MATTHEWS, PJ BARNES - American journal of , 1999 - Am Thoracic Soc Inhaled corticosteroids are widely prescribed for the treatment of stable chronic obstructive pulmonary disease (COPD), despite lack of proven efficacy. Because COPD involves airway inflammation and probable protease-antiprotease imbalance, we examined the effect of high dose ... Cited by 292 - Related articles - BL Direct - All 4 versions Managing change. nih.gov PC Barnes - BMJ: British Medical Journal, 1995 - ncbi.nlm.nih.gov Symmetrical small joint polyarthritis, with or without large joints also being affected, is the commonest presentation. In elderly patients the start of rheumatoid arthritis may be indistinguishable from polymyalgia rheumatica. Occasionally, rheumatoid arthritis may present as a ... Cited by 250 - Related articles - All 11 versions Allergen-induced late asthmatic reactions are associated with elevation of exhaled nitric oxide , BJ O'Connor, DJ Evans, PJ Barnes - American journal of , 1995 - Am Thoracic Soc The concentration of nitric oxide (NO) is increased in the exhaled air of asthmatic patients and may reflect cytokine-mediated inflammation in the airways. We investigated whether allergen-induced inflammation causes an elevation in the level of exhaled NO. Of 25 ... Cited by 260 - Related articles - BL Direct - All 4 versions Acute and chronic effects of cigarette smoking on exhaled nitric oxide Robbins, D Yates, V Keatings, PJ Barnes - American journal of , 1995 - 171.66.122.149 Cigarette smoking is associated with an increased risk of respiratory tract infections, chronic airway disease, and cardiovascular diseases, all of which may be modulated by endogenous nitric oxide (NO). We have investigated whether cigarette smoking reduces the production ... Cited by 259 - Related articles - BL Direct - All 4 versions A comparison of low-dose inhaled budesonide plus theophylline and high-dose inhaled budesonide for moderate asthma nejm.org , KF Chung, BJ O'Connor, PJ Barnes - England Journal of , 1997 - content.nejm.org Results Both treatments resulted in improvements in lung function that were sustained throughout the study. As compared with treatment with high-dose budesonide, treatment with low-dose budesonide plus theophylline resulted in greater improvements in forced vital capacity (P = 0.03) and ... Cited by 259 - Related articles - BL Direct - All 10 versions Activation and localization of transcription factor, nuclear factor-kappa B, in asthma atsjournals.org KRISHNAN, IANM ADCOCK, PJ BARNES - American journal of , 1998 - Am Thoracic Soc Asthma is associated with increased expression of inflammatory proteins including cytokines, enzymes, and adhesion molecules. Induction of many of the genes for these proteins is regulated by the transcription factor, nuclear factor- B (NF- B). We therefore examined ... Cited by 263 - Related articles - BL Direct - All 4 versions Elevated levels of exhaled nitric oxide in bronchiectasis Hansell, RB Logan-Sinclair, PJ Barnes - American journal of , 1995 - 171.66.122.149 ... SA Kharitonov, AU Wells, BJ O'Connor, PJ Cole, DM Hansell, RB Logan-Sinclair and PJ Barnes Department of Thoracic Medicine, National Heart and Lung Institute, London, England. ... Home page SA KHARITONOV and PJ BARNES Exhaled Markers of Pulmonary Disease Am. ... Cited by 232 - Related articles - BL Direct - All 4 versions Mechanisms in COPD* chestpubs.org PJ Barnes - Chest, 2000 - chestjournal.chestpubs.org Although considerable progress has been made in understanding the cellular and molecular mechanisms of asthma, much less attention has been paid to COPD. The inflammatory process in COPD is very different from that in asthma, with different inflammatory cells, mediators, ... Cited by 249 - Related articles - BL Direct - All 6 versions Changes in sputum eosinophils predict loss of asthma control 171.66.122.149 A Jatakanon, SAM Lim, PJ Barnes - American journal of , 2000 - 171.66.122.149 Exacerbations of asthma are likely to be due to an increase in airway inflammation. We have studied noninvasive markers of airway inflammation in asthma exacerbations induced by reducing the dose of inhaled corticosteroids. Following a 2-wk run-in period, mild exacerbations ... Cited by 244 - Related articles - BL Direct - All 5 versions Cytokine production induced by Mycobacterium tuberculosis lipoarabinomannan. Relationship to chemical structure PF Barnes , D Chatterjee, JS Abrams, S - The Journal of , 1992 - Am Assoc Immnol 0022-1767/92/1492-0541$02.00/0 Copyright 0 1992 by The American Association of Immunologists THE JOURNAL OF 1MMUNOLOGY ... Vol. 149, 541-547. No. 2. July 15. 1992 Printed in USA ... CYTOKINE PRODUCTION INDUCED BY Mycobacterium tuberculosis ... Cited by 250 - Related articles - All 4 versions Muscarinic receptor subtypes insubtypes in Airways PJ Barnes , P Minette, J Maclagan - Trends in Pharmacological Sciences, 1988 - Elsevier Subtypes of muscarinic receptor have recently been shown to exist in the airways of several species, including humans. M 1 receptors may be present in sympathetic nerves and parasympathetic ganglia. M 2 receptors on cholinergic nerves (autoreceptors) and M 3 receptors on ... Cited by 213 - Related articles - BL Direct - All 8 versions T-cell cytokine responses in human infection with Mycobacterium tuberculosis nih.gov Lin, DV Iyer, J Gong, JS Abrams, PF Barnes - Infection and , 1995 - Am Soc Microbiol MING ZHANG,1 YUANGUANG LIN,1 DINAKAR V. IYER,1 JIANHUA GONG,1 JOHN S. ABRAMS,2 AND PETER F. BARNES1* Division of Infectious Diseases, Department of Medicine, University of Southern California School of Medicine, Los Angeles, California ... Cited by 228 - Related articles - BL Direct - All 9 versions
标签: 呼吸病学家
