Volume 362 Number 3 January 21, 2010 This Week in the Journal Listen to This Week's Audio Summary Submit Answer Perspective Original Articles Clinical Practice Review Article Images in Clinical Medicine Case Records of the Massachusetts General Hospital Editorials Correspondence Continuing Medical Education Searchthe Journal NOW AT NEJM.ORG Interactive Medical Cases Perspective Medicare and Medical Technology The Growing Demand for Relevant Outcomes P.J. Neumann and S. Tunis ONLINE FIRST Free Full Text Cottage Industry to Postindustrial Care The Revolution in Health Care Delivery S.J. Swensen and Others ONLINE ONLY Free Full Text Erythropoiesis-Stimulating Agents Time for a Reevaluation E.F. Unger and Others Free Full Text Accelerating the Use of Electronic Health Records in Physician Practices S. Shea and G. Hripcsak Free Full Text Original Articles top Treatment with Monoclonal Antibodies against Clostridium difficile Toxins I. Lowy and Others CME Exam Lethal Skeletal Dysplasia in Mice and Humans Lacking the Golgin GMAP-210 P. Smits and Others Percent Emphysema, Airflow Obstruction, and Impaired Left Ventricular Filling R.G. Barr and Others A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis L. Kappos and Others ONLINE FIRST Free Full Text Oral Fingolimod or Intramuscular Interferon for Relapsing Multiple Sclerosis J.A. Cohen and Others ONLINE FIRST Free Full Text A Placebo-Controlled Trial of Oral Cladribine for Relapsing Multiple Sclerosis G. Giovannoni and Others ONLINE FIRST Free Full Text Acyclovir and Transmission of HIV-1 from Persons Infected with HIV-1 and HSV-2 C. Celum and Others ONLINE FIRST Free Full Text Projected Effect of Dietary Salt Reductions on Future Cardiovascular Disease K. Bibbins-Domingo and Others ONLINE FIRST Free Full Text Brief Report: Lack of Cyclophilin B in Osteogenesis Imperfecta with Normal Collagen Folding A.M. Barnes and Others ONLINE FIRST Free Full Text Clinical Practice top Systolic Heart Failure J.J.V. McMurray Full Text Audio CME Exam Review Article top Medical Progress: WilliamsBeuren Syndrome B.R. Pober Images in Clinical Medicine top Extramedullary Hematopoiesis Associated with -Thalassemia E. Smitaman and A.N. Rubinowitz Free Full Text Hydropneumothorax P.-H. Chen and X.-Z. Lin Free Full Text Case Records of the Massachusetts General Hospital top Case 2-2010: A 47-Year-Old Man with Abdominal and Flank Pain E.M. Isselbacher and Others CME Exam Editorials top Clostridium difficile Beyond Antibiotics L. Kyne Achondrogenesis Type 1A From Mouse to Human H.H. Freeze The Shrinking Heart in Chronic Obstructive Pulmonary Disease A. Vonk-Noordegraaf Oral Therapy for Multiple Sclerosis Sea Change or Incremental Step? W.M. Carroll ONLINE FIRST Free Full Text Compelling Evidence for Public Health Action to Reduce Salt Intake L.J. Appel and C.A.M. Anderson ONLINE FIRST Free Full Text Correspondence top Defibrillator Implantation Early after Myocardial Infarction Interleukin-2 Therapy in Patients with HIV Infection Doxycycline for Mansonella perstans Infection Case 33-2009: A Woman with Fever after Cesarean Section Contaminated Dietary Supplements Free Full Text Balancing No Blame with Accountability in Patient Safety Lovastatin in X-Linked Adrenoleukodystrophy Continuing Medical Education top Click here for CME information and links.
Volume 362 Number 2 January 14, 2010 This Week in the Journal Listen to This Week's Audio Summary Submit Answer Perspective Original Articles Review Article Images in Clinical Medicine Case Records of the Massachusetts General Hospital Editorials Clinical Implications of Basic Research Correspondence Continuing Medical Education Searchthe Journal NOW AT NEJM.ORG Download NEJM articles to PowerPoint Slide Sets it's fast and easy Perspective Tobacco Control and Free Speech An American Dilemma R. Bayer and M. Kelly ONLINE FIRST Free Full Text The Constitutionality of the Individual Mandate for Health Insurance J.M. Balkin ONLINE FIRST Free Full Text Play-or-Pay Insurance Reforms for Employers Confusion and Inequity B. Herring and M.V. Pauly Free Full Text Uncomfortable Arithmetic Whom to Cover versus What to Cover K. Baicker and A. Chandra Free Full Text Ranking 37th Measuring the Performance of the U.S. Health Care System C.J.L. Murray and J. Frenk Free Full Text Original Articles top Deployment and the Use of Mental Health Services among U.S. Army Wives A.J. Mansfield and Others Free Full Text Morphine Use after Combat Injury in Iraq and Post-Traumatic Stress Disorder T.L. Holbrook and Others Free Full Text Comparison of Ustekinumab and Etanercept for Moderate-to-Severe Psoriasis C.E.M. Griffiths and Others CME Exam Preoperative Biliary Drainage for Cancer of the Head of the Pancreas N.A. van der Gaag and Others Brief Report: Tracheal Allotransplantation after Withdrawal of Immunosuppressive Therapy P. Delaere and Others Review Article top Current Concepts: Nosocomial Bacterial Meningitis D. van de Beek and Others CME Exam Images in Clinical Medicine top Generalized Ostraceous Psoriasis S.A. Arias-Santiago and R. Naranjo-Sintes Free Full Text Postoperative Tracheal Stenosis A. Datta and A. Cale Free Full Text Case Records of the Massachusetts General Hospital top Case 1-2010: A 75-Year-Old Man with Hypertension, Hyperglycemia, and Edema G.T. McMahon and Others CME Exam Editorials top Prevention of Psychiatric Problems among Military Personnel and Their Spouses M.J. Friedman Free Full Text Preoperative Biliary Stents in Pancreatic Cancer Proceed with Caution T.H. Baron and R.A. Kozarek Immune Evasion by Chimeric Trachea M. Sykes Clinical Implications of Basic Research top A Seminal Finding for Prostate Cancer? J. Huang and O.N. Witte Correspondence top Cardiac-Resynchronization Therapy Comparative Efficacy of Influenza Vaccines Free Full Text Disclosure of the Genetic Risk of Alzheimers Disease Bone Marrow Aspiration and Biopsy Lack of Population Diversity in Commonly Used Human Embryonic Stem-Cell Lines Continuing Medical Education top Click here for CME information and links.
Dear Prof. Peiyang: New articles: colleagues in your discipline have identified the following article(s) as being of interest: Article Title Discipline Rele- vance News- worthiness Diagnosing delayed cerebral ischemia with different CT modalities in patients with subarachnoid hemorrhage with clinical deterioration. Stroke Neurology 6 6 Hospital Doctor/Hospitalists 6 5 Internal Medicine 6 5 Trastuzumab for patients with axillary-node-positive breast cancer: results of the FNCLCC-PACS 04 trial. J Clin Oncol Surgery - Oncology 7 6 Oncology - Breast 6 6 Transobturator tape compared with tension-free vaginal tape for stress incontinence: a randomized controlled trial. Obstet Gynecol Surgery - Urology 6 7 Randomized, controlled trial of an intervention for toddlers with autism: the Early Start Denver Model. Pediatrics GP/FP/Mental Health 6 6 Antidepressant drug effects and depression severity: a patient-level meta-analysis. JAMA General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6
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1 . Sex life and sexual function in men and women before and after total disc replacement compared with posterior lumbar fusion. Spine J. 2009 Dec;9(12):987-94. Epub 2009 Oct 12. (Original) 2 . Dabigatran versus warfarin in the treatment of acute venous thromboembolism. N Engl J Med. 2009 Dec 10;361(24):2342-52. Epub . (Original) 3 . Extended-release niacin or ezetimibe and carotid intima-media thickness. N Engl J Med. 2009 Nov 26;361(22):2113-22. Epub 2009 Nov 15. (Original) 4 . Using CT colonography as a triage technique after a positive faecal occult blood test in colorectal cancer screening. Gut. 2009 Sep;58(9):1242-9. Epub 2009 Jul 21. (Original) 5 . Bicarbonate supplementation slows progression of CKD and improves nutritional status. J Am Soc Nephrol. 2009 Sep;20(9):2075-84. Epub 2009 Jul 16. (Original) 6 . Revascularization versus medical therapy for renal-artery stenosis. N Engl J Med. 2009 Nov 12;361(20):1953-62. (Original) 7 . Revascularization versus medical therapy for renal-artery stenosis. N Engl J Med. 2009 Nov 12;361(20):1953-62. (Original) 8 . Critically Ill patients with 2009 influenza A(H1N1) in Mexico. JAMA. 2009 Nov 4;302(17):1880-7. Epub 2009 Oct 12. (Original) 9 . On-pump versus off-pump coronary-artery bypass surgery. N Engl J Med. 2009 Nov 5;361(19):1827-37. (Original) 10 . Surgical mask vs N95 respirator for preventing influenza among health care workers: a randomized trial. JAMA. 2009 Nov 4;302(17):1865-71. Epub 2009 Oct 1. (Original) 11 . Surgical mask vs N95 respirator for preventing influenza among health care workers: a randomized trial. JAMA. 2009 Nov 4;302(17):1865-71. Epub 2009 Oct 1. (Original) 12 . Combined effects of routine blood pressure lowering and intensive glucose control on macrovascular and microvascular outcomes in patients with type 2 diabetes: New results from the ADVANCE trial. Diabetes Care. 2009 Nov;32(11):2068-74. Epub 2009 Aug 3. (Original) 13 . Combined effects of routine blood pressure lowering and intensive glucose control on macrovascular and microvascular outcomes in patients with type 2 diabetes: New results from the ADVANCE trial. Diabetes Care. 2009 Nov;32(11):2068-74. Epub 2009 Aug 3. (Original) 14 . Clinical and economic effects of iNO in premature newborns with respiratory failure at 1 year. Pediatrics. 2009 Nov;124(5):1333-43. Epub 2009 Oct 19. (Original) 15 . Diclofenac for acute pain in children. Cochrane Database Syst Rev. 2009 Oct 7;(4):CD005538. (Review) 16 . A selective endothelin-receptor antagonist to reduce blood pressure in patients with treatment-resistant hypertension: a randomised, double-blind, placebo-controlled trial. Lancet. 2009 Oct 24;374(9699):1423-31. Epub 2009 Sep 11. (Original) 17 . Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials. Lancet. 2009 Oct 17;374(9698):1339-50. (Original) 18 . Accuracy of plasma B-type natriuretic peptide to diagnose significant cardiovascular disease in children: the Better Not Pout Children! Study. J Am Coll Cardiol. 2009 Oct 6;54(15):1467-75. (Original) 19 . Nortriptyline and gabapentin, alone and in combination for neuropathic pain: a double-blind, randomised controlled crossover trial. Lancet. 2009 Oct 10;374(9697):1252-61. Epub 2009 Sep 30. (Original) 20 . Selective serotonin reuptake inhibitors in pregnancy and congenital malformations: population based cohort study. BMJ. 2009 Sep 23;339:b3569. doi: 10.1136/bmj.b3569. (Original) 21 . Radial extracorporeal shockwave treatment compared with supervised exercises in patients with subacromial pain syndrome: single blind randomised study. BMJ. 2009 Sep 15;339:b3360. doi: 10.1136/bmj.b3360. (Original) 22 . The clinical course of ANCA small-vessel vasculitis on chronic dialysis. Kidney Int. 2009 Sep;76(6):644-51. Epub 2009 Jun 17. (Original) 23 . QUARANTINED: Response to a Monovalent 2009 Influenza A (H1N1) Vaccine - Preliminary Report N Engl J Med. 2009 Dec 17;361(25):2405-13. Epub 2009 Sep 10. (Original) 24 . Comparison between lidocaine-prilocaine cream (EMLA) and mepivacaine infiltration for pain relief during perineal repair after childbirth: a randomized trial. Am J Obstet Gynecol. 2009 Aug;201(2):186.e1-5. Epub 2009 Jun 26. (Original) 25 . Cardiac-resynchronization therapy for the prevention of heart-failure events. N Engl J Med. 2009 Oct 1;361(14):1329-38. Epub 2009 Sep 1. (Original)
Dear Prof. Peiyang: New articles: colleagues in your discipline have identified the following article(s) as being of interest: Article Title Discipline Rele- vance News- worthiness Laparoscopic surgery for pelvic pain associated with endometriosis. Cochrane Database Syst Rev Gynecology 6 5 250 microg or 500 microg interferon beta-1b versus 20 mg glatiramer acetate in relapsing-remitting multiple sclerosis: a prospective, randomised, multicentre study. Lancet Neurol Neurology 6 5 Clinical efficacy and safety of abatacept in methotrexate-naive patients with early rheumatoid arthritis and poor prognostic factors. Ann Rheum Dis Rheumatology 7 6 Multinational, double-blind, phase III study of prednisone and either satraplatin or placebo in patients with castrate-refractory prostate cancer progressing after prior chemotherapy: the SPARC trial. J Clin Oncol Oncology - Genitourinary 6 6 Callosal lesion predicts future attacks after clinically isolated syndrome. Neurology Neurology 5 5 Birth and adult residence in the Stroke Belt independently predict stroke mortality. Neurology Public Health 5 5 Neurology 5 4 General Practice(GP)/Family Practice(FP) 3 3 General Internal Medicine-Primary Care(US) 3 3 Sleep apnea in young abstinent recreational MDMA (``ecstasy``) consumers. Neurology Neurology 4 4 Psychiatry 4 4 Continuation of Low-Dose Aspirin in Peptic Ulcer Bleeding: A Randomized Trial. Ann Intern Med Cardiology 6 6 Gastroenterology 6 6 Surgery - Gastrointestinal 4 5 Inflammation and thrombosis biomarkers and incident frailty in postmenopausal women. Am J Med Geriatrics 5 4 Gynecology 4 4 Effect of fibrates on lipid profiles and cardiovascular outcomes: a systematic review. Am J Med Endocrine 6 6 Cardiology 6 4 Internal Medicine 5 5 Home telehealth for diabetes management: a systematic review and meta-analysis. Diabetes Obes Metab General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 Effect of adjunct metformin treatment on levels of plasma lipids in patients with type 1 diabetes. Diabetes Obes Metab Internal Medicine 5 5 Comparison of vildagliptin and thiazolidinedione as add-on therapy in patients inadequately controlled with metformin: results of the GALIANT trial--a primary care, type 2 diabetes study. Diabetes Obes Metab General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 Endocrine 5 4 Sequential therapy or triple therapy for Helicobacter pylori infection: systematic review and meta-analysis of randomized controlled trials in adults and children. Am J Gastroenterol General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6 Internal Medicine 6 6 Gastroenterology 6 5 Pediatrics (General) 5 4 Clinical Features of the Initial Cases of 2009 Pandemic Influenza A (H1N1) Virus Infection in China. N Engl J Med Infectious Disease 7 5 Respirology/Pulmonology 6 6 Pediatrics (General) 6 5 Emergency Medicine 6 5 General Internal Medicine-Primary Care(US) 5 4 General Practice(GP)/Family Practice(FP) 5 4 Long-Term Outcome Associated with Early Repolarization on Electrocardiography. N Engl J Med Cardiology 6 6 Comprehensive self-management for irritable bowel syndrome: randomized trial of in-person vs. combined in-person and telephone sessions. Am J Gastroenterol Gastroenterology 6 5 General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 Long-term use of statins and risk of colorectal cancer: a population-based study. Am J Gastroenterol Gastroenterology 5 5 Clinical relevance of HER2 overexpre ssion/amplification in patients with small tumor size and node-negative breast cancer. J Clin Oncol Surgery - Oncology 6 5 The Vulnerable Elders-13 Survey Predicts 5-Year Functional Decline and Mortality Outcomes in Older Ambulatory Care Patients. J Am Geriatr Soc Geriatrics 6 4 Weight gain within the normal weight range predicts ultrasonographically detected fatty liver in healthy Korean men. Gut Gastroenterology 5 5 Can chemotherapy be discontinued in unresectable metastatic colorectal cancer? The GERCOR OPTIMOX2 Study. J Clin Oncol Gastroenterology 5 4 Molecular predictors of progression-free and overall survival in patients with newly diagnosed glioblastoma: a prospective translational study of the German Glioma Network. J Clin Oncol Neurology 5 5 Effect of epoetin alfa on survival and cancer treatment-related anemia and fatigue in patients receiving radical radiotherapy with curative intent for head and neck cancer. J Clin Oncol Hematology/Thrombosis 6 5 Randomized phase III trial of gemcitabine-based chemotherapy with in situ RRM1 and ERCC1 protein levels for response prediction in non-small-cell lung cancer. J Clin Oncol Respirology/Pulmonology 4 4 Nadroparin for the prevention of thromboembolic events in ambulatory patients with metastatic or locally advanced solid cancer receiving chemotherapy: a randomised, placebo-controlled, double-blind study. Lancet Oncol Hematology/Thrombosis 6 4 Oncology - General 5 4 A randomized double-blind controlled trial of intra-annular radiofrequency thermal disc therapy--a 12-month follow-up. Pain Neurology 5 6 Ketamine produces effective and long-term pain relief in patients with Complex Regional Pain Syndrome Type 1. Pain Anesthesiology 6 7 Low-dose fentanyl-midazolam combination improves sevoflurane induction in adults. Can J Anaesth Anesthesiology 5 3 GP/FP/Anesthesia 4 5 MMP12, Lung Function, and COPD in High-Risk Populations. N Engl J Med Internal Medicine 5 6 General Practice(GP)/Family Practice(FP) 4 3 General Internal Medicine-Primary Care(US) 4 3 Ginkgo biloba for Preventing Cognitive Decline in Older Adults: A Randomized Trial. JAMA Psychiatry 7 5 Internal Medicine 6 6 General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Geriatrics 6 4 Improving the quality of care for infants: a cluster randomized controlled trial. CMAJ Pediatrics (General) 7 6 Respirology/Pulmonology 6 6 Infectious Disease 5 5 Smoking of crack cocaine as a risk factor for HIV infection among people who use injection drugs. CMAJ Psychiatry 6 5 The reliability of nonreconstructed computerized tomographic scans of the abdomen and pelvis in detecting thoracolumbar spine injuries in blunt trauma patients with altered mental status. J Bone Joint Surg Am Surgery - Neurosurgery 6 5 Emergency Medicine 6 4 Neurology 5 4 Duration and magnitude of the postoperative risk of venous thromboembolism in middle aged women: prospective cohort study. BMJ General Practice(GP)/Family Practice(FP) 7 6 General Internal Medicine-Primary Care(US) 7 6 Surgery - General 7 5 Hospital Doctor/Hospitalists 6 6 Internal Medicine 6 6 Risk of cardiovascular disease and all cause mortality among patients with type 2 diabetes prescribed oral antidiabetes drugs: retrospective cohort study using UK general practice research database. BMJ Internal Medicine 7 5 General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6 Cardiology 6 5 Endocrine 6 5 Does arthroscopic acromioplasty provide any additional value in the treatment of shoulder impingement syndrome?: a two-year randomised controlled trial. J Bone Joint Surg Br Surgery - Orthopaedics 6 7 Immune response after a single vaccination against 2009 influenza A H1N1 in USA: a preliminary report of two randomised controlled phase 2 trials. Lancet Infectious Disease 7 4 Public Health 6 5 General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Safety and immunogenicity of a 2009 pandemic influenza A H1N1 vaccine when administered alone or simultaneously with the seasonal influenza vaccine for the 2009-10 influenza season: a multicentre, randomised controlled trial. Lancet General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6 Infectious Disease 6 4 Safety and immunogenicity of 2009 pandemic influenza A H1N1 vaccines in China: a multicentre, double-blind, randomised, placebo-controlled trial. Lancet Infectious Disease 7 5 General Practice(GP)/Family Practice(FP) 6 4 General Internal Medicine-Primary Care(US) 6 4 Effect of multiple physiotherapy sessions on functional outcomes in the initial postoperative period after primary total hip replacement: a randomized controlled trial. Arch Phys Med Rehabil Surgery - Orthopaedics 5 4 Early maximal strength training is an efficient treatment for patients operated with total hip arthroplasty. Arch Phys Med Rehabil Physical Medicine and Rehabilitation 5 5 Surgery - Orthopaedics 5 5 Hydrophilic catheters versus noncoated catheters for reducing the incidence of urinary tract infections: a randomized controlled trial. Arch Phys Med Rehabil Infectious Disease 5 5 Neurology 4 4 Inspiratory muscle strength as a determinant of functional capacity early after coronary artery bypass graft surgery. Arch Phys Med Rehabil Surgery - Cardiac 6 5 Cardiology 3 3 The natural history of non-alcoholic fatty liver disease in children: a follow-up study for up to 20 years. Gut Pediatrics (General) 5 5 Self-harm and risk of motor vehicle crashes among young drivers: findings from the DRIVE Study. CMAJ Public Health 6 6 Psychiatry 6 5 A 7-year prospective, randomized, clinical, and radiographic study after arthroscopic bankart reconstruction using 2 different types of absorbable tack. Am J Sports Med Surgery - Orthopaedics 5 5 Patellar tendon versus hamstring tendon autografts for anterior cruciate ligament reconstruction: a randomized controlled trial using similar femoral and tibial fixation methods. Am J Sports Med Surgery - Orthopaedics 6 5 The long-term effect of 2 postoperative rehabilitation programs after anterior cruciate ligament reconstruction: a randomized controlled clinical trial with 2 years of follow-up. Am J Sports Med Physical Medicine and Rehabilitation 6 6 A network meta-analysis of randomized controlled trials of biologics for rheumatoid arthritis: a Cochrane overview. CMAJ Rheumatology 7 6 General Practice(GP)/Family Practice(FP) 6 4 General Internal Medicine-Primary Care(US) 6 4 Internal Medicine 5 6 The Enhancing Secondary Prevention in Coronary Artery Disease trial. CMAJ General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6 Internal Medicine 6 5 Cardiology 4 3 Systematic review: prediction of perioperative cardiac complications and mortality by the revised cardiac risk index. Ann Intern Med Hospital Doctor/Hospitalists 6 6 Internal Medicine 6 6 Anesthesiology 6 5 General Practice(GP)/Family Practice(FP) 5 4 General Internal Medicine-Primary Care(US) 5 4 Cardiology 4 4 Serious bacterial infections in febrile outpatient pediatric heart transplant recipients. Acad Emerg Med Pediatric Hospital Medicine 4 4 Cultural competency training and performance reports to improve diabetes care for black patients: a cluster randomized, controlled trial. Ann Intern Med Endocrine 5 4 General Practice(GP)/Family Practice(FP) 3 3 General Internal Medicine-Primary Care(US) 3 3 Forced euvolemic diuresis with mannitol and furosemide for prevention of contrast-induced nephropathy in patients with CKD undergoing coronary angiography: a randomized controlled trial. Am J Kidney Dis Nephrology 6 5 Sodium bicarbonate plus isotonic saline versus saline for prevention of contrast-induced nephropathy in patients undergoing coronary angiography: a randomized controlled trial. Am J Kidney Dis Nephrology 6 5 Cardiology 5 3 Prehypertension, obesity, and risk of kidney disease: 20-year follow-up of the HUNT I study in Norway. Am J Kidney Dis Internal Medicine 6 6 Nephrology 6 5 Cardiology 4 5 Rosuvastatin in the Prevention of Stroke Among Men and Women With Elevated Levels of C-Reactive Protein. Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER). Circulation General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6 Internal Medicine 6 6 Cardiology 6 6 Neurology 6 5 Cycle control with a 21-day compared with a 24-day oral contraceptive pill: a randomized controlled trial. Obstet Gynecol Gynecology 6 4 Is investigation of patients with haemoptysis and normal chest radiograph justified?. Thorax Oncology - Lung 5 5 Natriuretic peptides and troponins in pulmonary embolism: a meta-analysis. Thorax Hematology/Thrombosis 5 6 Prior adverse pregnancy outcome and the risk of stillbirth. Obstet Gynecol GP/FP/Obstetrics 7 6 Preventing surgical-site infections in nasal carriers of Staphylococcus aureus. N Engl J Med Hospital Doctor/Hospitalists 6 5 Internal Medicine 6 5 Pediatric Hospitalizations Associated with 2009 Pandemic Influenza A (H1N1) in Argentina. N Engl J Med Respirology/Pulmonology 6 5
Medicine Top 10 Papers Rank Paper Citations This Period (Jul-Aug 09) Rank Last Period (May-Jun 09) 1 J. Yu, et al. , Induced pluripotent stem cell lines derived from human somatic cells, Science , 318(5858): 1917-20, 21 December 2007. *243HE 78 3 2 The ACCORD Study Group (H.C. Gerstein, et al. ), Effects of intensive glucose lowering in type 2 diabetes , New Engl. J. Med. , 358(24): 2545-59, 12 June 2008. *311IJ 77 1 3 The ONTARGET Investigators ( S. Yusuf , et al. ), Telmisartan, ramipril, or both in patients at high risk for vascular events, New Engl. J. Med. , 358(15): 1547-59, 10 April 2008. *285NK 67 4 4 The ADVANCE Collaborative Group (A. Patel, et al. ), Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes , New Engl. J. Med. , 358(24): 2560-72, 12 June 2008. *311IJ 62 2 5 J.M. Llovet, et al. , Sorafenib in advanced hepatocellular carcinoma, New Engl. J. Med. , 359(4): 378-90, 24 July 2008. *329FK 51 7 6 R.R. Holman, et al. , 10-year follow-up of intensive glucose control in type 2 diabetes, New Engl. J. Med. , 359(15): 1577-89, 9 October 2008. *358FS 45 6 7 R.M. Klevens, et al. , Invasive methicillin-resistant Staphylococcus aureus infections in the United States, JAMA , 298(15): 1763-71, 17 October 2007. *220WF 44 8 Cancer Genome Atlas Research Network (L. Chin, et al. ), Comprehensive genomic characterization defines human glioblastoma genes and core pathways, Nature , 455(7216): 1061-8, 23 October 2008. *363FG 44 9 S.D. Wiviott, et al. , Prasugrel versus clopidogrel in patients with acute coronary syndromes, New Engl. J. Med. , 357(20): 2001-15, 15 November 2007. *230RV 39 10 F.H. Schrder , et al. , Screening and prostate-cancer mortality in a randomized European study, New Engl. J. Med. , 360(13): 1320-8, 26 March 2009. *423VP 38
TABLE OF CONTENTS January 2010 Volume 16, Issue 1 Editorial News Correspondence Book Review News and Views Community Corner Between Bedside and Bench Research Highlights Brief Communication Articles Letters Technical Reports Corrigenda Errata Advertisement Biomarker Discovery Pilot Grants Biomarkers hold great promise for biomedical research, including diagnostics, drug discovery, and personalized medicine. To encourage biomarker research, RayBiotech is now accepting applications for pilot grants . Deadline for application is January 31, 2010. Details and applications available at: RayBiotech.com/Grant . Recommend to your library Web feed Available online only Subscribe Advertisement Roche and Nature Medicine present: Roche - Nature Medicine Translational Neuroscience Symposium 2010: Innovative Translational Approaches to Brain Disorders April 20-21, 2010 Roche Forum Buonas, Switzerland At this meeting, we will showcase new approaches to the treatment of neurological disorders and discuss future directions with the ultimate goal of improving the care of patients with brain diseases. For more information visit: www.nature.com/natureconferences/tns2010/ Nature Medicine Podcast Top Switched on New drugs fight cancer through epigenetics, and researchers explore early development that's close to the heart. Plus, we review the journal's first 15 years and the road that lies ahead. Listen Now Editorial Top Nature Medicine , reloaded p1 doi:10.1038/nm0110-1 Molecular medicine has undergone profound changes since the publication of the first issue of Nature Medicine 15 years ago this month. To keep up with these changes, we strengthen our commitment to publishing the best research and the most topical newsand commentary on translational medicine by adding more pages to the journal. Full Text | PDF News Top Biomarkers still off the mark for detecting breast cancer p3 MikeMay doi:10.1038/nm0110-3 Full Text | PDF To boost breast cancer research, a center banks on healthy tissue p4 MeganScudellari doi:10.1038/nm0110-4a Full Text | PDF Embryonic stem cell lines given the go-ahead p4 ElieDolgin doi:10.1038/nm0110-4b Full Text | PDF Better forecasting urged to avoid drug waste p5 ElieDolgin doi:10.1038/nm0110-5 Full Text | PDF Forecast calls for clouds over biological computing p6 MikeMay doi:10.1038/nm0110-6a Full Text | PDF Top 10 pharma firings of 2009 p6 doi:10.1038/nm0110-6b Full Text | PDF Algorithms aim to improve hunt for disease markers p7 ChristianTorres doi:10.1038/nm0110-7a Full Text | PDF Matchmaking service links up researchers to wallflower drugs p7 CharlotteSchubert doi:10.1038/nm0110-7b Full Text | PDF African networks launch to boost clinical trial capacity p8 ElieDolgin doi:10.1038/nm0110-8a Full Text | PDF China offers billions in loans to boost health research in Africa p8 GeorginaKenyon doi:10.1038/nm0110-8b Full Text | PDF Pandemic blows lid off laws limiting mercury in vaccines p9 CharlotteSchubert doi:10.1038/nm0110-9a Full Text | PDF In prevention push, AIDS program prioritizes research p9 CassandraWillyard doi:10.1038/nm0110-9b Full Text | PDF Painkiller concerns grow ahead of new guidelines p10 StuHutson doi:10.1038/nm0110-10a Full Text | PDF Caution urged on tobacco research p10 VickiBrower doi:10.1038/nm0110-10b Full Text | PDF To save lives, initiative pushes for standardized diagnostic tools p11 StuHutson doi:10.1038/nm0110-11a Full Text | PDF Penalty payouts from pharma rise p11 doi:10.1038/nm0110-11b Full Text | PDF Institute of Medicine calls for savvier vaccine strategy p12 CharlotteSchubert doi:10.1038/nm0110-12a Full Text | PDF For cost effectiveness, real data trumps trial results p12 ChristianTorres doi:10.1038/nm0110-12b Full Text | PDF Bioethicists renew call for changes to prison research p13 EricaWestly doi:10.1038/nm0110-13a Full Text | PDF Britain reevaluates taxes on patent income p13 ElieDolgin doi:10.1038/nm0110-13b Full Text | PDF Exec salaries look up in life sciences p13 doi:10.1038/nm0110-13c Full Text | PDF News in brief pp14 - 15 doi:10.1038/nm0110-14 Full Text | PDF Straight talk with... Eric Green pp16 - 17 EricaWestly doi:10.1038/nm0110-16 Eric Green, the new head of the US National Human Genome Research Institute (NHGRI), has been involved with genomics since the term was first coined in the 1980s. Erica Westly spoke with Green about where he sees the genomics field heading and what role he thinks the NHGRI should have in the American health care system. Abstract | Full Text | PDF The saving switch pp18 - 21 CassandraWillyard doi:10.1038/nm0110-18 The epigenome consists of a system of chemical tags that attach to our DNA and its associated molecules, switching genes on and off. But the system is not without glitchesand scientists think that the misplacement of these tags can cause disease. This idea has led to new drugs that aim to correct gene activity (and obliterate disease) by altering the proteins around which DNA winds. Cassandra Willyard examines whether this approach will unlock the long-awaited promise of epigenetic therapy. Full Text | PDF Drug ads move online, creating a web of regulatory challenges p22 MeredithWadman doi:10.1038/nm0110-22 Full Text | PDF Correspondence Top Nicotinamide and neutrophilia p23 AbramHoffer doi:10.1038/nm0110-23a Full Text | PDF Reply to: Nicotinamide and neutrophilia p23 JuliaSkokowa and KarlWelte doi:10.1038/nm0110-23b Full Text | PDF Book Review Top Personalizing medicine p24 Edison TLiu reviews The Language of Life: DNA and the Revolution in Personalized Medicine by Francis S. Collins doi:10.1038/nm0110-24 Full Text | PDF News and Views Top Cloaked virus slips between cells pp25 - 27 Kathryn SJones and Patrick LGreen doi:10.1038/nm0110-25 A common retrovirus encases itself in an extracellular matrix, enabling its transfer between T4 cells. The discovery of this new mode of infectivity has the potential to lead to new ways to combat the virus, human T cell leukemia virus type 1 (HTLV-1), which is associated with cancers and inflammatory disorders (pages 83-89). Full Text | PDF See also: Article by Pais-Correia et al. Hypertension finds a new rhythm pp27 - 28 Bernard CRossier doi:10.1038/nm0110-27 Blood pressure oscillates with the circadian rhythm, and a molecular mechanism has now been discovered (pages 67-74). The results point to a new genetic risk factor for hypertension and to a potential new target against this condition. Full Text | PDF See also: Article by Doi et al. A NOD for autophagy pp28 - 30 Mihai GNetea and Leo A BJoosten doi:10.1038/nm0110-28 Susceptibility to Crohn's disease has been linked to polymorphisms in genes involved in two pathophysiological pathways: autophagy and the recognition of bacterial peptidoglycan by nucleotide oligomerization domain-2 (NOD2), an intracellular receptor. Two studies link these pathways by showing that recognition of bacterial peptidoglycans by NOD2 induces autophagy and bacterial clearance. Full Text | PDF See also: Article by Cooney et al. Myelodysplasia: battle in the bone marrow pp30 - 32 YanLiu, TakashiAsai and Stephen DNimer doi:10.1038/nm0110-30 Innate immune signals and p53 contribute to the 5q- myelodysplastic syndrome, an acquired bone marrow failure disorder (pages 49-58 and 59-66). Full Text | PDF See also: Article by Starczynowski et al. | Article by Barlow et al. Huntington's disease: tagged for clearance pp32 - 33 DimitriKrainc doi:10.1038/nm0110-32 The neuronal accumulation of mutant huntingtin is a hallmark of Huntington's disease. New research shows that post-translational modifications of the mutant protein promote its clearance, uncovering new therapeutic targets for this disorder. Full Text | PDF Vessel remodeling in the newborn: platelets fill the gap pp33 - 35 RonaldClyman and SylvainChemtob doi:10.1038/nm0110-33 In newborn infants, permanent closure of a major blood vessel connecting the main pulmonary artery to the aorta is essential to allow adequate circulation of blood to major organs. Platelet aggregation now emerges as a crucial step in this process in newborn mice and, possibly, in preterm infants (pages 75-82). Full Text | PDF See also: Article by Echtler et al. Migration or evasion pp35 - 36 CornelisMelief doi:10.1038/nm0110-35 Tumors use many strategies to evade the immune system. A new study adds a new trick to the listinhibiting the migration of dendritic cells from tumors toward lymph nodes (pages 98-105). Full Text | PDF See also: Article by Villablanca et al. Medicine JOBS of the week UW Bioengineering Faculty Position in Imaging University of Washington Bioengineering Department Seattle, WA 98195 Postdoctoral Research Assistant University of Dundee Dundee, UK Scientist Postdoc in Polymer Sciences / Pharmaceutical Technology GKSS Forschungszentrum GmbH, Centre for Biomaterial Development of the Institute of Polymer Research Teltow Germany PhD Position: Application of Hydrogen Autotrophic Bacteria for CO2 and H2 Sequestering into Useable Bacterial Biomass Biological Sciences, Queen's University Belfast Belfast, Northern Ireland, UK Lemur Mongoose monitoring (volunteer) Moidjio CRCAD Centre for Research Conservation And Development Comoros More Science jobs from Medicine EVENT Translational Medicine 03.-05.02.10 San Fran, US More science events from Community Corner Top Gene therapy tackles demyelinating disease p37 doi:10.1038/nm0110-37 Full Text | PDF Between Bedside and Bench Top Kidney complications doi:10.1038/nm0110-38 The vasculature suffers damage as a result of diabetes, often leading to conditions such as kidney failure. In bench to bedside, Christian Rask-Madsen and George King examine endogenous factors that protect against damage of the vasculature, such as vascular-endothelial growth factor (VEGF). Recent studies report that VEGF is expressed by kidneys and fends off renal failure; such findings have implications for the development of treatments that harness endogenous factors and sound a note of caution for the therapeutic use of VEGF inhibitors. People with end-stage renal disease often die of cardiovascular complications and clinical studies have shown that one popular class of drugs, statins, does not work in this population. In bedside to bench, S. Ananth Karumanchi and Ravi Thadhani show how this clinical finding is spurring research into the biological mechanisms behind cardiovascular death in people with kidney disease. Kidney complications: Why don't statins always work? pp38 - 40 S AnanthKarumanchi and RaviThadhani doi:10.1038/nm0110-38 Full Text | PDF Kidney complications: Factors that protect the diabetic vasculature pp40 - 41 ChristianRask-Madsen and George LKing doi:10.1038/nm0110-40 Full Text | PDF Research Highlights Top Research Highlights pp42 - 43 doi:10.1038/nm0110-42 Full Text | PDF Brief Communication Top Characterization of the human neutrophil alloantigen-3a pp45 - 48 AndreasGreinacher, JanWesche, ElkeHammer, BirgittFurll, UweVolker, AngelikaReil and JurgenBux doi:10.1038/nm.2070 A serious complication of blood transfusions is transfusion-related acute lung injury, which can be caused by antibodies in the donor blood that recognize and activate host neutrophils. Andreas Greinacher and his colleagues now determine the molecular identity of the antigen recognized by one of these antibodies, termed human neutrophil alloantigen-3a, as a variant of the choline transporter-like protein-2. This finding opens the door to systematic screening of blood donors and recipients. First paragraph | Full Text | PDF Articles Top Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype pp49 - 58 Daniel TStarczynowski, FlorianKuchenbauer, BobArgiropoulos, SandySung, RyanMorin, AndrewMuranyi, MartinHirst, DonnaHogge, MarcoMarra, Richard AWells, RenaBuckstein, WanLam, R KeithHumphries and AlyKarsan doi:10.1038/nm.2054 For myelodysplastic syndromes caused by deletion of chromosome 5q, Daniel Starczynowski et al . provide evidence that decreased expre ssion of two miRNAs in this regionmiR-145 and miR-146acontributes to abnormal megakaryocyte differentiation and platelet production and progression of the disease to either bone marrow failure or leukemia. The authors also provide a mechanistic explanation for these effects by which loss of these two miRNAs leads to derepression of innate immune signaling. Abstract | Full Text | PDF See also: News and Views by Liu et al. | Article by Barlow et al. A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome pp59 - 66 Jillian LBarlow, Lesley FDrynan, Duncan RHewett, Luke RHolmes, SilviaLorenzo-Abalde, Alison LLane, Helen EJolin, RichardPannell, Angela JMiddleton, See HengWong, Alan JWarren, James SWainscoat, JacquelineBoultwood and Andrew N JMcKenzie doi:10.1038/nm.2063 In individuals with 5q- syndrome, deletion within chromosome 5q is associated with hematological abnormalities. Jillian Barlow et al . now create an animal model of the disease using chromosomal engineering to remove a corresponding region of the mouse genome. The resulting hematological abnormalities resemble those in the human disease, and the authors provide genetic evidence that p53 activation contributes to the disease process. Abstract | Full Text | PDF See also: News and Views by Liu et al. | Article by Starczynowski et al. Salt-sensitive hypertension in circadian clock-deficient Cry -null mice involves dysregulated adrenal Hsd3b6 pp67 - 74 MasaoDoi, YukariTakahashi, RieKomatsu, FumiyoshiYamazaki, HiroyukiYamada, ShogoHaraguchi, NoriakiEmoto, YasushiOkuno, GozohTsujimoto, AkihiroKanematsu, OsamuOgawa, TakeshiTodo, KazuyoshiTsutsui, Gijsbertus T Jvan der Horst and HitoshiOkamura doi:10.1038/nm.2061 The circadian clock controls many aspects of human physiology, and disturbances in circadian rhythms have been linked to cardiovascular disease. Masao Doi et al . now delineate a new pathway by which the circadian clock influences hormone production and blood pressure in miceclock genes control expre ssion of an aldosterone biosynthetic enzyme, such that increased activity of this enzyme in mice with a disrupted circadian clock may account for the increased aldosterone levels and salt-sensitive hypertension seen in these mice. Abstract | Full Text | PDF See also: News and Views by Rossier Platelets contribute to postnatal occlusion of the ductus arteriosus pp75 - 82 KatrinEchtler, KonstantinStark, MichaelLorenz, SandraKerstan, AxelWalch, LuiseJennen, MartinaRudelius, StefanSeidl, ElisabethKremmer, Nikla REmambokus, Marie-Luisevon Bruehl, JonFrampton, BerendIsermann, OrsolyaGenzel-Boroviczeny, ChristianSchreiber, JulindaMehilli, AdnanKastrati, MarkusSchwaiger, Ramesh AShivdasani and SteffenMassberg doi:10.1038/nm.2060 Premature infants can suffer from an anatomical defect in which the ductus arteriosus, a blood vessel that connects the pulmonary artery and the aorta during fetal development, fails to close at birth. Katrin Echtler et al . now show that platelets are needed for closure in mice and that reduced platelet function may be clinically relevant: in a retrospective study of preterm human infants, low platelet counts were associated with the presence of an unclosed ductus arteriosus. Abstract | Full Text | PDF See also: News and Views by ClymanChemtob Biofilm-like extracellular viral assemblies mediate HTLV-1 cell-to-cell transmission at virological synapses pp83 - 89 Ana-MonicaPais-Correia, MartinSachse, StephanieGuadagnini, ValentinaRobbiati, RemiLasserre, AntoineGessain, OlivierGout, AndresAlcover and Maria-IsabelThoulouze doi:10.1038/nm.2065 The virus HTLV-1 is thought to pass between cells through synapses formed when infected lymphocytes make contact with other T cells. Isabelle Thoulouze and her colleagues uncover an alternative mechanism for the cell-to-cell transmission of this virus. They show that HTLV-1 virions bud at the plasma membrane and are held at the cell surface in structures reminiscent of bacterial biofilms. When infected lymphocytes make contacts with other cells, the adhesive viral assemblies are rapidly transferred to to the surface of the new lymphocyte, from which the virions mediate a new round of infection. Abstract | Full Text | PDF See also: News and Views by JonesGreen NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation pp90 - 97 RachelCooney, JohnBaker, OliverBrain, BenedicteDanis, TicaPichulik, PhilipAllan, David J PFerguson, Barry JCampbell, DerekJewell and AlisonSimmons doi:10.1038/nm.2069 Mutations in NOD2a bacterial sensor in dendritic cellsand mutations in genes related to autophagosome function have been linked to Crohn's disease. Alison Simmons and her colleagues link these susceptibility genes in a single functional pathway. They show that triggering of NOD2 induces autophagy, resulting in increased bacterial antigen presentation on the surface of the dendritic cell. They also show that this process goes awry in dendritic cells expressing the susceptibility variants from individuals with Crohn's disease. Abstract | Full Text | PDF See also: News and Views by NeteaJoosten Tumor-mediated liver X receptor- activation inhibits CC chemokine receptor-7 expre ssion on dendritic cells and dampens antitumor responses pp98 - 105 Eduardo JVillablanca, LauraRaccosta, DanZhou, RaffaellaFontana, DanielaMaggioni, AuroraNegro, FrancescaSanvito, MaurilioPonzoni, BarbaraValentinis, MarcoBregni, AlessandroPrinetti, Knut RSteffensen, SandroSonnino, Jan-AkeGustafsson, ClaudioDoglioni, ClaudioBordignon, CatiaTraversari and VincenzoRusso doi:10.1038/nm.2074 Sterol metabolism modulates immune responses through liver X receptor activation. Tumors harness this signaling pathway and can escape immunosurveillance by inhibiting dendritic cell migration to tumor-draining lymph nodes. Abstract | Full Text | PDF See also: News and Views by Melief Letters Top A mitotic transcriptional switch in polycystic kidney disease pp106 - 110 FranciscoVerdeguer, StephanieLe Corre, EvelyneFischer, CelineCallens, SergeGarbay, AntoniaDoyen, PeterIgarashi, FabiolaTerzi and MarcoPontoglio doi:10.1038/nm.2068 Deficiency of the transcription factor HNF-1 results in kidney cyst formation. Marco Pontoglio and his colleagues now show that HNF-1 normally remains bound to condensed chromatin during mitosis to facilitate the rapid expre ssion of key genes involved in cell quiescence post-mitosis. In the absence of HNF-1, these genes fail to express, and the kidney epithelial cells continue to proliferate, resulting in cysts. Abstract | Full Text | PDF A key role for orexin in panic anxiety pp111 - 115 Philip LJohnson, WilliamTruitt, Stephanie DFitz, Pamela EMinick, AmyDietrich, SonalSanghani, LilTraskman-Bendz, Andrew WGoddard, LenaBrundin and AnanthaShekhar doi:10.1038/nm.2075 Orexin, a neuropeptide best known for its role in arousal and its absence in people with narcolepsy, is also involved in the pathophysiology of panic anxiety disorder. First paragraph | Full Text | PDF Technical Reports Top Real-time imaging reveals the single steps of brain metastasis formation pp116 - 122 YvonneKienast, Louisavon Baumgarten, MartinFuhrmann, Wolfgang E FKlinkert, RolandGoldbrunner, JochenHerms and FrankWinkler doi:10.1038/nm.2072 One of the major challenges of metastasis research is being able to track the fate of individual metastasizing cancer cells over time. Here, Kienast et al. describe an animal model in which multiphoton laser scanning microscopy is used to image the steps involved in the establishment of brain metastasis in vivo . The movement of systemically injected, red fluorescent protein-labeled tumor cells is monitored over several weeks, revealing potential targets for therapy. Abstract | Full Text | PDF Generation of stable monoclonal antibody-producing B cell receptor-positive human memory B cells by genetic programming pp123 - 128 Mark JKwakkenbos, Sean ADiehl, EtsukoYasuda, Arjen QBakker, Caroline M Mvan Geelen, Michael VLukens, Grada Mvan Bleek, Myra NWidjojoatmodjo, Willy M J MBogers, HenrikMei, AndreasRadbruch, Ferenc AScheeren, HergenSpits and TimBeaumont doi:10.1038/nm.2071 Kwakkenbos et al . describe an in vitro method to generate antibody-secreting B cell lines from human peripheral blood memory B cells by transducing them with retroviral vectors encoding Bcl-6 and Bcl-xL. The approach can be used to stably and simultaneously produce high levels of B cell receptor (BCR) on the cell surface and secreted immunoglobulins, useful for studying BCR signaling and producing antigen-specific antibodies. Abstract | Full Text | PDF Corrigenda Top Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells p129 KeisukeIto, AtsushiHirao, FumioArai, KeiyoTakubo, SahokoMatsuoka, KanaMiyamoto, MasakoOhmura, KazuhitoNaka, KentaroHosokawa, YasuoIkeda and ToshioSuda doi:10.1038/nm0110-129a Full Text | PDF Modulating hedgehog signaling can attenuate the severity of osteoarthritis p129 Alvin CLin, Brian LSeeto, Justyna MBartoszko, Michael AKhoury, HeatherWhetstone, LouisaHo, ClaireHsu, Amanda SAli and Benjamin AAlman doi:10.1038/nm0110-129b Full Text | PDF Errata Top Drugs in the headlines p129 VictoriaAranda doi:10.1038/nm0110-129c Full Text | PDF Drugs in the headlines p129 VictoriaAranda doi:10.1038/nm0110-129d Full Text | PDF
Search | Image of the Week | Physician Jobs | Subscribe Volume 362 Number 1 January 7, 2010 This Week in the Journal Listen to This Week's Audio Summary Submit Answer Perspective Original Articles Clinical Practice Images in Clinical Medicine Clinical Problem-Solving Editorial Sounding Board Correspondence Continuing Medical Education Searchthe Journal NOW AT NEJM.ORG NEJM Weekly Audio Summary Perspective Erythropoiesis-Stimulating Agents Time for a Reevaluation E.F. Unger and Others ONLINE FIRST Free Full Text Ranking 37th Measuring the Performance of the U.S. Health Care System C.J.L. Murray and J. Frenk ONLINE FIRST Free Full Text Health Care Reform and the Need for Comparative-Effectiveness Research A.I. Mushlin and H. Ghomrawi ONLINE ONLY Free Full Text Patient-Centered Medical Homes in Ontario W.W. Rosser and Others ONLINE ONLY Free Full Text Nearing Negotiations Reconciling Key Differences between House and Senate Reform Measures J.K. Iglehart ONLINE ONLY Free Full Text Googling Ourselves What Physicians Can Learn from Online Rating Sites S. Jain Free Full Text Ensuring the Fiscal Sustainability of Health Care Reform M.E. Chernew and Others Free Full Text Payment Reform The Need to Harmonize Approaches in Medicare and the Private Sector P.V. Lee and Others Free Full Text Original Articles top Preventing Surgical-Site Infections in Nasal Carriers of Staphylococcus aureus L.G.M. Bode and Others ChlorhexidineAlcohol versus PovidoneIodine for Surgical-Site Antisepsis R.O. Darouiche and Others CME Exam Severe 2009 H1N1 Influenza in Pregnant and Postpartum Women in California J.K. Louie and Others Free Full Text CME Exam Variants of DENND1B Associated with Asthma in Children P.M.A. Sleiman and Others Pediatric Hospitalizations Associated with 2009 Pandemic Influenza A (H1N1) in Argentina R. Libster and Others Free Full Text Clinical Practice top Stage IV Chronic Kidney Disease H. Abboud and W.L. Henrich Full Text Audio CME Exam Images in Clinical Medicine top Giant Abdominal Aortic Aneurysm J.L. Ebaugh and J.D. Raffetto Necrolytic Migratory Erythema L. McGevna and Z. Tavakkol Free Full Text Clinical Problem-Solving top Painful Purple Toes J.A. Johnson and Others A related Interactive Medical Case is available at NEJM.org Editorial top Minimizing Surgical-Site Infections R.P. Wenzel Sounding Board top Comparative Effectiveness and Health Care Spending Implications for Reform M.C. Weinstein and J.A. Skinner ONLINE FIRST Free Full Text Correspondence top Variation in Hospital Mortality Associated with Surgery Renal Failure in Cirrhosis Parenteral Nutrition in the Critically Ill Patient Screening for Colorectal Cancer The Case for Integrated Delivery Systems Free Full Text A Community Cluster of Oseltamivir-Resistant Cases of 2009 H1N1 Influenza Free Full Text Intravenous Zanamivir for Oseltamivir-Resistant 2009 H1N1 Influenza Free Full Text Continuing Medical Education top Click here for CME information and links.
1. Cancer statistics, 2007 Jemal, A. (2007), Ca-A Cancer Journal for Clinicians, Volume 57, Issue 1, Pages 43-66 Cited by: 3,159 2. Cancer statistics, 2006 Jemal, A. (2006), Ca-A Cancer Journal for Clinicians, Volume 56, Issue 2, Pages 106-130 Cited by: 2,843 3. Prevalence of overweight and obesity in the United States, 1999-2004 Ogden, C.L. (2006), Journal of the American Medical Association, Volume 295, Issue 13, Pages 1549-1555 Cited by: 2,498 4. Cancer statistics, 2008 Jemal, A. (2008), CA Cancer Journal for Clinicians, Volume 58, Issue 2, Pages 71-96 Cited by: 2,198 5. MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0 Tamura, K. (2007), Molecular Biology and Evolution, Volume 24, Issue 8, Pages 1596-1599 Cited by: 1,913 6. Heart disease and stroke statistics - 2006 Update: A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee Thom, T. (2006), Circulation, Volume 113, Issue 6, Pages e85-e151 Cited by: 1,097 7. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes Nissen, S.E. (2007), New England Journal of Medicine, Volume 356, Issue 24, Pages 2457-2471 Cited by: 1,022 8. Intensive insulin therapy in the medical ICU Van Den Berghe, G. (2006), New England Journal of Medicine, Volume 354, Issue 5, Pages 449-461 Cited by: 989 9. Heart disease and stroke statistics - 2007 Update: A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee Rosamond, W. (2007), Circulation, Volume 115, Issue 5, Pages e69-e171 Cited by: 942 10. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma Motzer, R.J. (2007), New England Journal of Medicine, Volume 356, Issue 2, Pages 115-124 Cited by: 877 11. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck Bonner, J.A. (2006), New England Journal of Medicine, Volume 354, Issue 6, Pages 567-578 Cited by: 873 12. Sorafenib in advanced clear-cell renal-cell carcinoma Escudier, B. (2007), New England Journal of Medicine, Volume 356, Issue 2, Pages 125-134 Cited by: 825 13. TGF in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells Veldhoen, M. (2006), Immunity, Volume 24, Issue 2, Pages 179-189 Cited by: 786 14. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer Sandler, A. (2006), New England Journal of Medicine, Volume 355, Issue 24, Pages 2542-2550 Cited by: 779 15. 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC) Mancia, G. (2007), Journal of Hypertension, Volume 25, Issue 6, Pages 1105-1187 Cited by: 776 16. Standards of medical care in diabetes - 2006 (2006), Diabetes Care, Volume 29, Issue SUPPL. 1, Pages S4-S42 Cited by: 753 17. Standards of medical care in diabetes - 2007 (2007), Diabetes Care, Volume 30, Issue SUPPL. 1, Pages S4-S41 Cited by: 660 18. Heart disease and stroke statistics-2008 Update: A report from the American heart association statistics committee and stroke statistics subcommittee Rosamond, W. (2008), Circulation, Volume 117, Issue 4, Pages e25-e46 Cited by: 659 19. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS) Miyakis, S. (2006), Journal of Thrombosis and Haemostasis, Volume 4, Issue 2, Pages 295-306 Cited by: 659 20. Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events Bhatt, D.L. (2006), New England Journal of Medicine, Volume 354, Issue 16, Pages 1706-1717 Cited by: 649
Volume 361 Number 27 December 31, 2009 This Week in the Journal Listen to This Weeks Audio Summary Submit Answer Perspective Original Articles Special Article Clinical Therapeutics Images in Clinical Medicine Case Records of the Massachusetts General Hospital Editorials Clinical Implications of Basic Research Correspondence Correction Continuing Medical Education Searchthe Journal NOW AT NEJM.ORG Listen to Clinical Practice articles Perspective Launching HITECH D. Blumenthal ONLINE FIRST Free Full Text Play-or-Pay Insurance Reforms for Employers Confusion and Inequity B. Herring and M.V. Pauly ONLINE FIRST Free Full Text Implementation and Enforcement of Health Care Reform Federal versus State Government T.S. Jost ONLINE ONLY Free Full Text Carrots, Sticks, and Health Care Reform Problems with Wellness Incentives H. Schmidt and Others ONLINE ONLY Free Full Text Senates Reform Package Wrapped Up in Time for Christmas J.K. Iglehart ONLINE ONLY Free Full Text Abortion Politics and Health Insurance Reform G.J. Annas Free Full Text Australias Winter with the 2009 Pandemic Influenza A (H1N1) Virus J.F. Bishop and Others Free Full Text The Emotional Epidemiology of H1N1 Influenza Vaccination D. Ofri Free Full Text Industry Influence on Comparative-Effectiveness Research Funded through Health Care Reform H.P. Selker and A.J.J. Wood Free Full Text Original Articles top MMP12, Lung Function, and COPD in High-Risk Populations G.M. Hunninghake and Others Genomewide Association Study of Leprosy F.-R. Zhang and Others Household Transmission of 2009 Pandemic Influenza A (H1N1) Virus in the United States S. Cauchemez and Others Free Full Text CME Exam Outbreak of 2009 Pandemic Influenza A (H1N1) at a New York City School J. Lessler and Others Free Full Text Special Article top Public Reporting of Discharge Planning and Rates of Readmissions A.K. Jha and Others Free Full Text Clinical Therapeutics top Activated Protein C for Sepsis S. Toussaint and H. Gerlach CME Exam Images in Clinical Medicine top Vanishing Mediastinal Mass M. de Perrot and Y. Shargall Radiation Pneumonitis after Radiotherapy for Breast Cancer E. Blke and C. Matuschek Free Full Text Case Records of the Massachusetts General Hospital top Case 41-2009: A 16-Year-Old Boy with Hypothermia and Frostbite R.L. Sheridan and Others CME Exam Editorials top Matrix Metalloproteinase 12, Asthma, and COPD G.G. Brusselle A Common Genetic Fingerprint in Leprosy and Crohns Disease? E. Schurr and P. Gros Clinical Implications of Basic Research top Aging Lost in Translation? P. Kapahi and J. Vijg Correspondence top Dabigatran versus Warfarin in Patients with Atrial Fibrillation Sex HormoneBinding Globulin and Risk of Type 2 Diabetes Correction: Maternal and Neonatal Herpes Simplex Virus Infections Free Full Text Human GM-CSF Autoantibodies and Reproduction of Pulmonary Alveolar Proteinosis Responses to 2009 H1N1 Vaccine in Children 3 to 17 Years of Age ONLINE FIRST Free Full Text Correction top Weight Loss with a Low-Carbohydrate, Mediterranean, or Low-Fat Diet Continuing Medical Education top Click here for CME information and links.
Dear Ms./ Mr., Merry Christmas and a Happy New Year!! We sincerely thank you for your contributions to the growth of our new journalJournal of Evidence-Based Medicine in the past year. Looking back over the last year, l The first Annual Editorial Board Meeting was held in Chengdu in January. Fifty-five great masters from 8 countries were selected as the board members of the journal. l Fifty-four invited papers, more than 50% from abroad, were published in 4 issues as follows: n Clinical Trials Registration n 2020Health for All n Medical Education Reform n Medical Rescue of the Wenchuan Earthquake l The download quantity for the PDF and HTML full-text papers is about 5,000. l The journal is now been assessed by ISI for the index of SCIE. The result will be known around the next New Year. Look into the New Year, l The online ahead of print publication will begin to operate as the year of 2010 comes. l Our new website is http://www.journalEBM.org l The coming topics in the pipeline include: n ADR/AE of Chinese Materia Medica Injections n Health for All, 2020 n Strategic Collaboration between WHO and the Cochrane Collaboration n Medical Education Reform You are warmly welcome to continually submit your papers to ebmjournal@gmail.com . Your consistently high quality of contributions is still expected! Youping Li Editor in Chief Liang Du Managing editor
Volume 361 Number 25 December 17, 2009 This Week in the Journal Listen to This Week's Audio Summary Submit Answer Perspective Original Articles Review Article Images in Clinical Medicine Interactive Medical Case Case Records of the Massachusetts General Hospital Editorials Sounding Board Clinical Implications of Basic Research Correspondence Continuing Medical Education Searchthe Journal NOW AT NEJM.ORG Interactive Medical Cases NEW Painful Purple Toes Test your skill with the fourth in our new series of Interactive Medical Cases, Painful Purple Toes . Direct the investigation and select the treatment for a 57-year-old man who presents with painful purple toes. Learn interactively, get immediate feedback, and compare your performance with that of others. Try the new case now . Perspective Rallying the Caucus The Democrats Struggle for Unity on Reform J.K. Iglehart ONLINE ONLY Free Full Text Uncomfortable Arithmetic Whom to Cover versus What to Cover K. Baicker and A. Chandra ONLINE FIRST Free Full Text Ending End-of-Life Phobia A Prescription for Enlightened Health Care Reform B.W. Corn ONLINE ONLY Free Full Text Health Care Reform A Republican View C. Grassley Free Full Text The Consequences of No A.L. Kellermann and L.S. Lewin Free Full Text Leveling the Field Ensuring Equity through National Health Care Reform B. Siegel and L. Nolan Free Full Text Original Articles top Response to a Monovalent 2009 Influenza A (H1N1) Vaccine M.E. Greenberg and Others Free Full Text A Novel Influenza A (H1N1) Vaccine in Various Age Groups F.-C. Zhu and Others Free Full Text CME Exam Trial of 2009 Influenza A (H1N1) Monovalent MF59-Adjuvanted Vaccine T.W. Clark and Others Free Full Text Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency S.D. Anker and Others CME Exam MMP12, Lung Function, and COPD in High-Risk Populations G.M. Hunninghake and Others ONLINE FIRST Free Full Text Genomewide Association Study of Leprosy F.-R. Zhang and Others ONLINE FIRST Free Full Text Review Article top Molecular Origins of Cancer: Molecular Basis of Colorectal Cancer S.D. Markowitz and M.M. Bertagnolli Images in Clinical Medicine top Frostbite H. Rehman and A. Seguin Hernia through the Foramen Omentale A. Basu and M. Jacobs Free Full Text Interactive Medical Case top Painful Purple Toes J.J. Ross and Others Free Full Text Case Records of the Massachusetts General Hospital top Case 39-2009: A 28-Year-Old Pregnant Woman with Acute Cardiac Failure P.T. OGara and Others CME Exam Editorials top Anemia and Iron Deficiency New Therapeutic Targets in Heart Failure? G.W. Dec Matrix Metalloproteinase 12, Asthma, and COPD G.G. Brusselle ONLINE FIRST Free Full Text A Common Genetic Fingerprint in Leprosy and Crohns Disease? E. Schurr and P. Gros ONLINE FIRST Free Full Text Sounding Board top The Agenda for Continuing Medical Education Limiting Industrys Influence L. Morris and J.K. Taitsman Clinical Implications of Basic Research top Gene Therapy for Color Blindness J. Bennett Correspondence top Treatment of Lung Cancer Asymptomatic Reactivation of JC Virus in Patients Treated with Natalizumab Coronary Calcium Screening Proposals for Payment Reform in Massachusetts Free Full Text Rapid-Test Sensitivity for Novel Swine-Origin Influenza A (H1N1) Virus in Humans Free Full Text Lack of Population Diversity in Human Embryonic Stem-Cell Lines ONLINE FIRST Free Full Text Continuing Medical Education top Click here for CME information and links.
http://sciencewatch.com/ana/hot/med/ WHAT'S HOT IN ... MEDICINE The Top Ten lists in Medicine feature papers published during the last two years (excluding review articles) that were most cited in current journal articles indexed by Thomson Reuters during a recent two-month period. Papers are ranked according to the latest bimonthly citation count. The articles below are accompanied by expert discussion and analysis (including comments from the papers authors) written by one of four veteran scientist-journalists and longtime ScienceWatch.com contributors. 2009 November/December 2009 KRAS Research Harbingers Personalized Cancer Care by David W. Sharp Recent research into mutations of the KRAS gene in metastatic colorectal cancer demonstrates that the presence of wild-type (non-mutated) KRAS in tumors is correlated with more-effective treatment with the anticancer agent panitumumab. Similar results have been obtained with the drug cetuximab. Such findings hasten the promise of personalizing cancer treatments for specific tumor types. View Article September/October 2009 Examining HPVs Role in Head and Neck Cancer by David W. Sharp With the role of human papillomavirus (HPV) in cervical cancer firmly established, researchers are now exploring HPVs possible causative action in cancers of the head and neck. One study comparing histories of patients with oropharyngeal cancer against controls suggested a strong association between the cancer and HPV infection, with factors such as sexual behavior and the number of sexual partners exerting an apparent influence. Specifics, such as the precise means of oral transmission, are still being elucidated. View Article July/August 2009 Obesity Surgery: Weighing The Effects on Mortality by David W. Sharp Recent studies have assessed the effects of anti-obesity surgery on mortality, comparing obese subjects who underwent gastric bypass and other procedures against obese controls who did not have surgery. Results indicated that surgery improved mortality rates and quality of life, with improvement apparently related to quantity of weight lost. Given the refinements in surgical techniques since these studies were initially launched in the 1980s, the current advantages are likely to be even greater. View Article May/June 2009 2008/09 Trials Ignite Debate about Regimen for Type 2 Diabetes by David W. Sharp Medicines most-cited papers are currently dominated by studies pertaining to type 2 diabetes and its management. In particular, recent trials have examined the effects of intensive blood-glucose lowering in the treatment of type 2 diabetes. Meta-analysis has suggested that this course of therapy is connected with a higher incidence of cardiovascular events and higher mortality rates, although further investigation is needed to clarify this matter and others related to treatment. View Article March/April 2009 The Intensive Insulin/Intensive Care Debate Waits for NICE-SUGAR by David W. Sharp Recent studies have examined the use of tight glycemic controlspecifically, intense insulin therapyfor patients with severe sepsis in intensive-care units. Although earlier trials suggested that such therapy improved mortality as compared with conventional intensive care, later studies indicated no significant difference and also suggested that low glycemic levels present a threat of their own. Clinicians will look to ongoing trials to clarify these matters. View Article January/February 2009 Colon Cancer Stem Cells Causing Breathless Excitement by David W. Sharp Recent highly cited papers in medicine investigate the increasing evidence pertaining to cancer stem cells. In one paper, for example, a team of researchers discusses a particular cell capable of initiating colon cancer. A deeper knowledge of these kinds of cellshow they behave, how they differ from one another, and how they interact with such factors as the cell-surface marker CD133will add to the understanding of oncogenesis and help point the way toward improved treatment strategies. View Article 2008 November/December 2008 Cancer ScreeningWhen Will It Be the Lungs Turn? by David W. Sharp A paper in the New England Journal of Medicine reports on a study of outcome following screening for lung cancer by spiral computed tomography. After screening individuals who were at risk for lung cancer due to smoking or occupational exposure to carcinogens, the researchers determined that those diagnosed with stage 1 lung cancer demonstrated substantial survival benefit from early treatment, demonstrating the effectiveness of annual screening.. View Article September/October 2008 In Two Different Cancers, Success with Drugs New and Old by David W. Sharp Recent cancer therapy has shown progress on two fronts: in chronic myeloid leukemia, the drug dasatinib has shown benefit in patients who are resistant to imatinib, while in gastric cancer, perioperative chemotherapy with the older agents epirubicin, cisplatin, and fluorouracil has been shown to improve survival when compared to surgery alone. View Article July/August 2008 Staph Report: Assessing MRSA Infections in the ER by David W. Sharp The emergence of methicillin-resistant Staphylococcus aureus , or MRSA, has become a serious health issue. A 2006 study of patients appearing in emergency rooms with skin or soft-tissue infections indicated that 76% had S. aureus, with 78% of those bacterial isolates showing resistance to methicillin. View Article May/June 2008 Genome-Wide Studies and Risk in Type 2 Diabetes by David W. Sharp Two papers in the current Medicine Top Ten discusses genome-wide association studies on type 2 diabetes and the genetic factors and processes associated with increased risk for the disease. View Article March/April 2008 Investigating Angiogenesis Inhibitors and Other Drugs in Kidney Cancer by David W. Sharp A comparatively recent treatment for renal-cell carcinoma involves tyrosine-kinase-inhibiting agents, including sunitinib, bevacizumab, and temsirolimus, to block angiogenesis and tumor-cell proliferation. Studies suggest that, compared to interferon, these agents improved survival. View Article January/February 2008 Bevacizumub: A Poke in the Eye for Macular Patients? by David W. Sharp Injection of the vascular endothelial growth-factor inhibitor bevacizumab, normally used in cancer, has been effective in treating the eye disorder known as age-related macular degeneration, but, in view of safety concerns that are currently under study, the manufacturer has curtailed its availability for this application. View Article
ADVERTISEMENT Interview with Dr. Christian Schumann regarding a poster presented this year at ECCO-ESMO. A retrospective analysis of TRUST data from German centres demonstrates that the long-term benefits associated with erlotinib treatment are independent of prognostic factors and therapeutic response. To see the full video interview, click here . Volume 361 Number 24 December 10, 2009 This Week in the Journal Listen to This Week's Audio Summary Submit Answer Perspective Original Articles Review Article Images in Clinical Medicine Case Records of the Massachusetts General Hospital Editorials Correspondence Other Points of View Corrections Continuing Medical Education Searchthe Journal NOW AT NEJM.ORG NEJM beta site Perspective Week 1 of the Senate Debate Amending the Reform Bill J.K. Iglehart ONLINE ONLY Free Full Text Ensuring the Fiscal Sustainability of Health Care Reform M.E. Chernew and Others ONLINE FIRST Free Full Text Payment Reform The Need to Harmonize Approaches in Medicare and the Private Sector P.V. Lee and Others ONLINE FIRST Free Full Text The Breadth of Hopes C. Feudtner Primary Care and Accountable Care Two Essential Elements of Delivery-System Reform D.R. Rittenhouse and Others Free Full Text The Supreme Court, Process Patents, and Medical Innovation A.S. Kesselheim Original Articles top Allogeneic Hematopoietic Stem-Cell Transplantation for Sickle Cell Disease M.M. Hsieh and Others CME Exam Platelet Inhibition with Cangrelor in Patients Undergoing PCI R.A. Harrington and Others CME Exam Intravenous Platelet Blockade with Cangrelor during PCI D.L. Bhatt and Others Dabigatran versus Warfarin in the Treatment of Acute Venous Thromboembolism S. Schulman and Others Clinical Features of the Initial Cases of 2009 Pandemic Influenza A (H1N1) Virus Infection in China B. Cao and Others ONLINE FIRST Free Full Text Review Article top Mechanisms of Disease: Telomere Diseases R.T. Calado and N.S. Young Images in Clinical Medicine top Blurred Vision after Cardiac Catheterization C.H. Meyer and F.G. Holz Free Full Text Ileocecal Intussusception J.D. Whitfield and G. Mostafa Free Full Text Case Records of the Massachusetts General Hospital top Case 38-2009: A 16-Year-Old Boy with Paroxysmal Headaches and Visual Changes S.D. Brass and Others CME Exam Editorials top Hematopoietic Stem-Cell Transplantation for Adults with Sickle Cell Disease M.R. Abboud Cangrelor A Champion Lost in Translation? A. Kastrati and G. Ndrepepa The Need for Science in the Practice of Public Health N. Lurie ONLINE FIRST Free Full Text Correspondence top Ticagrelor versus Clopidogrel in Acute Coronary Syndromes Intestinal Transplantation The Prometheus Payment Model Free Full Text Long-Term Follow-up of Survival in Hodgkin's Lymphoma A Community Cluster of Oseltamivir-Resistant Cases of 2009 H1N1 Influenza ONLINE FIRST Free Full Text Other Points of View top Act II Curve Bending D.Y. Patterson ONLINE ONLY Free Full Text Corrections top Intensity of Renal Support in Critically Ill Patients with Acute Kidney Injury Case 25-2008: A 43-Year-Old Man with Fatigue and Lesions in the Pituitary and Cerebellum Continuing Medical Education top Click here for CME information and links.
ONLINE FIRST To coincide with a presentation at a meeting of the American Society of Hematology, the following article was published at NEJM.org on December 6, 2009. Original Article Dabigatran versus Warfarin in the Treatment of Acute Venous Thromboembolism S. Schulman and Others Thank you for subscribing to the New England Journal of Medicine 's E-Mail Table of Contents service. The e-mail address for this subscription is: XUPEIYANG@VIP.163.COM To UNSUBSCRIBE, please click here . This will stop delivery of both the New England Journal of Medicine 's E-Mail Table of Contents service and Online First notifications. To UPDATE YOUR PREFERENCES at any time, click here or e-mail webmaster@nejm.org Please do not reply to this e-mail. This is an automated mailbox. If you have any questions or comments, please e-mail us at nejmcust@mms.org .
To ensure you receive the Resident e-Bulletin, add resebulletin@nejm.org to your address book. ADVERTISEMENT Visit NEJM CareerCenter to search physician jobs, apply online, and set up e-mail alerts to have jobs automatically sent to you. Teaching topics from the New England Journal of Medicine - Vol. 361, No. 23, December 3, 2009 NEJM Links: Current Table of Contents | Physician Jobs | Subscribe | Search NEJM THIS WEEK'S TEACHING TOPICS 1. Management of Lung Nodules Detected by CT Scanning: Why is right ventricular pacing deleterious? Clinical Pearls | Morning Report Question 2. Mitral-Valve Repair for Mitral-Valve Prolapse: What is the phenomenon of aldosterone escape? Clinical Pearls | Morning Report Questions also in this e-mail: Images in Clinical Medicine Image Challenge Audio Videos in Clinical Medicine Featured Job of the Week Printer Friendly Quote of the Week If past obesity trends continue unchecked, the negative effects on the health of the U.S. population will increasingly outweigh the positive effects gained from declining smoking rates. Failure to address continued increases in obesity could result in an erosion of the pattern of steady gains in health observed since early in the 20th century. S.T. Stewart, D.M. Cutler, and A.B. Rosen, Special Article, Forecasting the Effects of Obesity and Smoking on U.S. Life Expectancy top EDITOR'S NOTE: The New England Journal of Medicine is offering a two-week elective course for trainees and fellows PGY3 and higher who seek a deeper understanding of how a peer review journal works and editors make their decisions about publishing papers in the medical literature. It is a participatory elective based on the New England Journal of Medicine and taught at its editorial offices in Boston. The course will be held May 1728, 2010. The New England Journal of Medicine will not be responsible for transportation or housing. Participants must be present for the entire two weeks of the course. Interested trainees and fellows should apply at NEJM.org before January 15, 2010. Eight participants will be chosen. TEACHING TOPIC 1. Management of Lung Nodules Detected by CT Scanning ORIGINAL ARTICLE , Management of Lung Nodules Detected by Volume CT Scanning , R.J. van Klaveren and Others, Abstract | Full Text | PDF | PPT Slide Set EDITORIAL , Volume CT for Diagnosis of Nodules Found in Lung-Cancer Screening , J.L. Mulshine and D.M. Jablons, Extract | Full Text | PDF Participants who were at an increased risk for lung cancer were enrolled in a trial to determine whether CT screening reduces mortality from lung cancer. In the van Klaveren et al. paper, volume measurements and volume doubling times were used to evaluate the noncalcified lung nodules that were detected by CT scanning at baseline and at years 1, 2, and 4 of the trial. top Clinical Pearls Diagnostic Techniques in the Evaluation of Lung Nodules The use of multidetector computed tomography (CT) in lung-cancer screening trials involving subjects with an increased risk of lung cancer has highlighted the problem that the clinician has in deciding on the best course of action when noncalcified pulmonary nodules are detected by CT. Current practice has been to refer participants in these programs for additional diagnostic evaluation if they have a noncalcified nodule that is larger than 5 mm in diameter. The van Klaveren et al. study used software to evaluate a noncalcified nodule according to its volume or volume-doubling time. Growth was defined as an increase in volume of at least 25% between two scans. The first-round screening test was considered to be negative if the volume of a nodule was less than 50 mm 3 , if it was 50 to 500 mm 3 but had not grown by the time of the 3-month follow-up CT, or, in the case of those that had grown, if the volume-doubling time was 400 days or more. Performance of Volume and Volume-Doubling Time for Lung Nodules Among the 7557 participants in the screening group, a noncalcified nodule between 50 mm 3 and 500 mm 3 in volume was discovered in 1451 subjects at the first screening; 518 of the nodules had a volume-doubling time of more than 400 days on a follow-up scan at 3 months. When participants who had nodules with this slow volume-doubling time were considered together with subjects whose scans were classified as negative at the first screening, and the combined group was followed for 2 years, 20 lung cancers were detected. Thus, a negative scan, which included the presence of nodules with a slow volume-doubling time, was associated with a negative predictive value of 99.7%. Figure 1. Results of the First Round of Screening. Figure 2. Results of the Second Round of Screening. top Morning Report Question Q : What was the chance of finding lung cancer after a negative first-round test using the volume and volume-doubling time method? A : Among subjects in the van Klaveren et al. trial who were at high risk for lung cancer and screened in three rounds of CT scanning and in whom noncalcified pulmonary nodules were evaluated according to volume and volume-doubling time, the chances of finding lung cancer 1 and 2 years after a negative first-round test were 1 in 1000 and 3 in 1000, respectively. top TEACHING TOPIC 2. Mitral-Valve Repair for Mitral-Valve Prolapse CLINICAL THERAPEUTICS , Mitral-Valve Repair for Mitral-Valve Prolapse , S. Verma and T.G. Mesana, Extract | Full Text | PDF | PPT Slide Set A 55-year-old man presents with a holosystolic murmur of increasing intensity and is diagnosed with mitral-valve prolapse with severe mitral regurgitation. He is asymptomatic but has mildly depressed left ventricular function and mild left ventricular enlargement. Mitral-valve repair is recommended. Mitral-valve repair may result in a better survival rate than mitral-valve replacement, but mitral regurgitation can recur. top Clinical Pearls Epidemiology and Prognosis of Mitral-Valve Prolapse Mitral-valve prolapse is defined as the displacement of some portion of one or both leaflets of the mitral valve into the left atrium during systole. In developed countries, it is the most common cause of chronic mitral regurgitation with a prevalence of mitral-valve prolapse of about 2.5%. The disorder has both genetic and acquired forms, and several chromosomal loci for autosomal dominant mitral-valve prolapse have been identified. The natural history of mitral-valve prolapse is heterogeneous and is largely determined by the severity of mitral regurgitation. Although a majority of patients remain asymptomatic and may have a near-normal life expectancy, approximately 5 to 10% have progression to severe mitral regurgitation. Left untreated, mitral-valve prolapse with severe mitral regurgitation results in limiting symptoms, left ventricular dysfunction, heart failure, pulmonary hypertension, and atrial fibrillation. Spontaneous rupture of mitral chordae may occur, and endocarditis and stroke are serious complications. Figure 1. The Mitral Valve. Figure 2. Mitral-Valve Prolapse. Treatment for Mitral-Valve Prolapse with Mitral Regurgitation No randomized trials have compared medical management to surgery for severe mitral regurgitation due to mitral-valve prolapse. However, evidence from observational series strongly suggests that surgical intervention is beneficial. The goal of surgical correction for mitral-valve prolapse is to restore a competent mitral valve. There are two options for surgical correction of severe mitral regurgitation due to mitral-valve prolapse: valve replacement or valve repair. Mitral-valve replacement can be performed with the use of either a mechanical or a biologic prosthesis. The goals of mitral-valve repair are to obtain a proper line of coaptation on both leaflets, to correct annular dilatation, and to preserve (or repair, if necessary) the subvalvular apparatus. Figure 3. Special Repair Techniques. top Morning Report Questions Q : What is the mortality rate of patients with mitral-valve prolapse and severe mitral regurgitation? A : The mortality rate of persons who have mitral-valve prolapse with severe mitral regurgitation is approximately 6 to 7% per year. Q : What are the drawbacks of mitral-valve replacement? A : There are several drawbacks to mitral-valve replacement. These include the need for lifelong anticoagulation therapy and the risk of thromboembolism with the use of mechanical valves; the risk of prosthetic-valve deterioration and failure when bioprosthetic valves are used; and the risk of prosthetic-valve endocarditis. In addition, if the chordae tendineae are severed during surgery, the ventricular wall is no longer anchored to the valve apparatus, and the tethering effect of the chordae is lost. As a result, left ventricular wall stress increases and left ventricular function deteriorates. There are no randomized trials comparing mitral-valve repair with replacement. However, data from observational studies suggest that mitral repair is beneficial. Q : Which patients with mitral-valve prolapse should be treated? A : Patients who have severe mitral regurgitation with symptoms or with left ventricular dysfunction (ejection fraction, 60%), dilatation (left ventricular end-systolic dimension, 40 mm), or both should be offered surgery. Likewise, asymptomatic patients without left ventricular dysfunction or dilatation but with atrial fibrillation or pulmonary hypertension should be considered for surgery. Asymptomatic persons with mild-to-moderate mitral regurgitation and no evidence of left ventricular dysfunction or dilatation should be observed until the development of either symptoms or severe mitral regurgitation. top IMAGES IN CLINICAL MEDICINE IMAGE CHALLENGE Tuberculous Abscess Manifesting as Unilateral Gynecomastia Get PowerPoint Slide Anterior Sternal Dislocation Get PowerPoint Slide MORE IMAGES Question: What is the diagnosis? Check Your Answer 1. Central retinal vein occlusion 2. Cholesterol embolism 3. Retinoschisis 4. Temporal arteritis 5. Toxoplasmosis ABOUT THE IMAGE CHALLENGE top AUDIO VIDEOS IN CLINICAL MEDICINE Listen to this week's Audio Summary Recent Interviews Anthony Fauci on the challenges and prospects of an HIV vaccine Wafaa El-Sadr on the successes and shortcomings of PEPFAR's efforts to address the HIV epidemic in the developing world Allan Brandt discusses the provisions, benefits, and criticisms of legislation that would grant the FDA regulatory authority over tobacco products MORE INTERVIEWS Recent Clinical Practice Renal-Artery Stenosis Postexposure Prophylaxis for HIV Infection MORE CLINICAL PRACTICE Bone Marrow Aspiration and Biopsy Blood-Pressure Measurement Basic Splinting Techniques AnkleBrachial Index for Assessment of Peripheral Arterial Disease MORE VIDEOS top FEATURED JOB of the Week ADVERTISEMENT HOSPITALIST DELAWARE Outstanding opportunity for BC/BE Internist to join expanding hospitalist program. As a result of growth, our group, which was established in 1996, is in need of several hospitalists to join our team. The facilities we currently serve include Bayhealth Medical Center, Christiana Care, and St. Francis Hospital. Bayhealth Medical Center includes Kent General, located in the heart of Dover, a 231-bed facility; and Milford Memorial located near the Delaware beaches in Milford Delaware, a 141-bed facility.... Looking for a new practice opportunity? View this job and other listings at NEJM CareerCenter . Search now for both permanent and locum tenens jobs in many specialties. SPECIAL OFFER Get the latest medical news every morning in your inbox FREE Physician's First Watch provides the latest medical news in a brief daily clinical update, delivered to your inbox by 7:30 ET. Created by the physician-editors of Journal Watch and from the publishers of the New England Journal of Medicine. Sign up now for this FREE email alert! 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SEND US YOUR FEEDBACK E-mail the e-Bulletin editors with questions, comments or suggestions. Advertisement This document is meant as a guide to the NEJM; it is not intended to replace or reflect the entire contents of the Journal , but rather as a way to direct your attention to potential teaching topics contained in the contents of this week's NEJM. Subscribe to the Journal Thank you for subscribing to the New England Journal of Medicine 's Resident e-Bulletin . The e-mail address for this subscription is: XUPEIYANG@VIP.163.COM You are receiving this e-mail because you selected to receive the Resident e-Bulletin . If you wish to unsubscribe to the Resident e-Bulletin , please sign in to change your e-mail preferences. Please do not reply to this e-mail. This is an automated mailbox. If you have any questions or comments, please E-mail us. The New England Journal of Medicine 10 Shattuck Street, Boston, MA 02115-6094 Copyright 2009 Massachusetts Medical Society. All rights reserved.
Volume 361 Number 23 December 3, 2009 This Week in the Journal Listen to This Week's Audio Summary Submit Answer Perspective Original Articles Special Article Clinical Therapeutics Images in Clinical Medicine Clinical Problem-Solving Editorials Clinical Implications of Basic Research Correspondence Viral Insights Other Points of View Continuing Medical Education Searchthe Journal NOW AT NEJM.ORG Listen to Clinical Practice articles Perspective Settling in for a Long Debate J.K. Iglehart ONLINE ONLY Free Full Text Getting the Facts Straight on Health Care Reform J. Gruber ONLINE FIRST Free Full Text Abortion Politics and Health Insurance Reform G.J. Annas ONLINE FIRST Free Full Text America's Safety Net and Health Care Reform What Lies Ahead? I. Redlener and R. Grant Free Full Text Leveling the Field Ensuring Equity through National Health Care Reform B. Siegel and L. Nolan ONLINE FIRST Free Full Text The Emergency Use Authorization of Peramivir for Treatment of 2009 H1N1 Influenza D. Birnkrant and E. Cox Free Full Text Original Articles top Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand S. Rerks-Ngarm and Others Free Full Text CME Exam Management of Lung Nodules Detected by Volume CT Scanning R.J. van Klaveren and Others CME Exam AbacavirLamivudine versus TenofovirEmtricitabine for Initial HIV-1 Therapy P.E. Sax and Others Advanced Heart Failure Treated with Continuous-Flow Left Ventricular Assist Device M.S. Slaughter and Others Special Article top Forecasting the Effects of Obesity and Smoking on U.S. Life Expectancy S.T. Stewart and Others Clinical Therapeutics top Mitral-Valve Repair for Mitral-Valve Prolapse S. Verma and T.G. Mesana CME Exam Images in Clinical Medicine top Tuberculous Abscess Manifesting as Unilateral Gynecomastia J. Koh and A. Tee Anterior Sternal Dislocation S. Taslaq and R.C. Nordstrom Free Full Text Clinical Problem-Solving top A Crisis in Late Pregnancy A.S. Desai and Others A related Interactive Medical Case is available at NEJM.org Editorials top HIV Vaccine Trial Results An Opening for Further Research R. Dolin Free Full Text Volume CT for Diagnosis of Nodules Found in Lung-Cancer Screening J.L. Mulshine and D.M. Jablons Rise of the Machines Left Ventricular Assist Devices as Permanent Therapy for Advanced Heart Failure J.C. Fang Clinical Implications of Basic Research top A Look at the Low-Carbohydrate Diet S.R. Smith Correspondence top Radiation Exposure from Medical Imaging Procedures Uterine Fibroid Embolization Case 27-2009: A Woman with Fever, Rash, and Lymphadenopathy Emergence of Oseltamivir-Resistant Pandemic H1N1 Virus during Prophylaxis Free Full Text Viral Insights top Diagnostic Testing for 2009 Pandemic Influenza A (H1N1) Virus Infection in Hospitalized Patients T. Uyeki ONLINE ONLY Free Full Text Other Points of View top It Is Patients Who Most Need Tort Reform K. Coleman ONLINE ONLY Free Full Text Continuing Medical Education top Click here for CME information and links.
Check Your English Vocabulary for Medicine (Check Your English Vocabulary series) Updated to include new terms and references, this workbook helps nonnative English speakers improve their knowledge and understanding of core medical terminology. Students, nurses, doctors, and other medical staff can test and build their medical English vocabulary with a combination of self-study exercises, practical speaking activities, and amusing crosswords, puzzles, and word games. Ideal for home and class-based study, these exercises ensure that language is not a barrier for medical professionals whose first language is not English. download: Check Your English Vocabulary for Medicine
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