科学网—标签 - 子宫内膜异位症

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diana767 2012-12-29 20:29

子宫内膜异位症是子宫内长了痈，导致月经流血过多，导致贫血、免疫力低。通过五分类血常规辨证，用简单的几味中药即可治愈。

xupeiyang 2010-12-16 08:39

两个基因变异与子宫内膜异位症相关　由英国、澳大利亚和美国研究人员组成的一国际研究小组进行了一项全基因组关联研究(GWAS)，对来自三国的约5500名子宫内膜异位症患者和近万名健康志愿者的基因数据进行比较。他们发现，两个基因变异与子宫内膜异位症的发病率明显相关。第一个变异存在于7号染色体上，该染色体被认为与子宫及其内膜发育有关；第二个变异则在1号染色体上，与WNT4基因相近。　　该项研究首席研究员、牛津大学的克里娜桑德瓦博士指出，虽然科学家们知道子宫内膜异位症是可以遗传的，但此前尚未找到任何会明显影响该病发病率的变异基因，新发现则提供了一个强有力的证据，证明了基因变异会使一些妇女更容易罹患子宫内膜异位症，这是一个重大突破。 http://tech.sina.com.cn/d/2010-12-15/17184987750.shtml http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi A-query: Endometriosis C-query: genes The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 495 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here . The results of this search are saved under id # 7450 and can be accessed from the start page after you leave this session. There are 1078 terms on the current B-list ( 487 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin. To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms. http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/view_b_txt.cgi?ID=7450 job id # 7450 started Wed Dec 15 20:17:47 2010 Max_citations: 50000 Stoplist: /var/www/html/arrowsmith_uic/data/stopwords_pubmed Ngram_max: 3 7450 Search ARROWSMITH A A_query_raw: EndometriosisWed Dec 15 20:18:35 2010 A query = Endometriosis started Wed Dec 15 20:18:36 2010 A query resulted in 17314 titles 7450 Search ARROWSMITH C C_query_raw: genes Wed Dec 15 20:18:50 2010 C: genes 858851 A: pubmed_query_A 17314 AC: ( Endometriosis ) AND ( genes ) 495 C query = genes started Wed Dec 15 20:18:50 2010 C query resulted in 50000 titles A AND C query resulted in 495 titles 6604 B-terms ready on Wed Dec 15 20:23:07 2010 Sem_filter: Genes Molecular Sequences, and Gene Protein Names 718 B-terms left after filter executed Wed Dec 15 20:31:39 2010 718 B-terms left after filter executed Wed Dec 15 20:31:41 2010 718 B-terms left after filter executed Wed Dec 15 20:31:44 2010 718 B-terms left after filter executed Wed Dec 15 20:31:46 2010 Sem_filter: Genes Molecular Sequences, and Gene Protein Names 718 B-terms left after filter executed Wed Dec 15 20:32:08 2010 Sem_filter: Genes Molecular Sequences, and Gene Protein Names 1 B-terms left after filter executed Wed Dec 15 20:34:43 2010 Sem_filter: Genes Molecular Sequences, and Gene Protein Names Sem_filter: Genes Molecular Sequences, and Gene Protein Names 1 B-terms left after filter executed Wed Dec 15 20:35:08 2010 Sem_filter: Chemicals Drugs C_query_raw: genes Wed Dec 15 20:39:55 2010 C: genes 858851 A: pubmed_query_A 17314 AC: ( Endometriosis ) AND ( genes ) 495 C query = genes started Wed Dec 15 20:39:57 2010 C query resulted in 50000 titles A AND C query resulted in 495 titles 6604 B-terms ready on Wed Dec 15 20:40:42 2010 Sem_filter: Chemicals Drugs 1078 B-terms left after filter executed Wed Dec 15 20:48:19 2010 1078 B-terms left after filter executed Wed Dec 15 20:48:22 2010 1078 B-terms left after filter executed Wed Dec 15 20:48:24 2010 1078 B-terms left after filter executed Wed Dec 15 20:48:29 2010 B-list on Wed Dec 15 20:49:45 2010 1 cox-2 2 toll receptor 3 transferase m1 4 vegf 5 receptor gene polymorphism 6 cyclooxygenase-2 7 beta catenin 8 expression matrix metalloproteinase 9 ppar gamma 10 proteasome 11 endothelial growth factor 12 inflammatory cytokine 13 growth factor vegf 14 mapk 15 interleukin-1 receptor 16 histone deacetylase inhibitor 17 estrogen receptor alpha 18 proinflammatory cytokine 19 peroxisome proliferator activated 20 proliferator activated receptor 21 cetrorelix 22 defensin 23 hypoxia inducible factor-1alpha 24 antagonist cetrorelix 25 matrix metalloproteinase 26 activin 27 expression cyclin 28 hla drb1 29 metalloproteinase-1 30 leptin receptor 31 ppar 32 rapamycin 33 platinum based 34 il-10 35 splice 36 paclitaxel 37 transcription factor 38 x receptor 39 endometrial integrin 40 chemokine receptor 41 fenofibrate 42 estrogen receptor beta 43 activin a 44 progesterone receptor 45 tamoxifen 46 chemokine 47 nuclear factor kappab 48 cyclin dependent kinase 49 beta catenin pathway 50 cyclin dependent 51 steroid receptor 52 histone deacetylase 53 il-6 54 nuclear receptor 55 peroxisome proliferator 56 cadherin 57 forkhead 58 p38 mitogen activated 59 atorvastatin 60 ubiquitin 61 protease activated receptor 62 cdna 63 cyclin d1 64 single nucleotide 65 fibroblast growth factor-2 66 gnrh 67 aryl hydrocarbon receptor 68 igfbp-3 69 angiogenic factor 70 aquaporin 71 transferase m1 t1 72 e cadherin 73 activin receptor 74 gonadotropin releasing hormone 75 mitochondrial dna 76 il-8 77 tgf beta 78 cyclin 79 toll 80 mucinous 81 reactive oxygen 82 angiostatin 83 retinoid x receptor 84 azole 85 matrix metalloproteinase expression 86 metformin 87 t polymorphism 88 apoptosis inducing ligand 89 factor vegf receptor 90 timp-1 91 tissue inhibitor metalloproteinase-1 92 aromatase 93 metalloproteinase expression 94 angiogenic 95 cyclin b1 96 estrogen receptor 97 leukemia inhibitory factor 98 gonadotropin releasing 99 interleukin-6 100 statin 101 o-methyltransferase polymorphism 102 nuclear factor 103 mitogen activated protein 104 hla dqa1 105 immunophilin 106 transforming growth factor 107 estrogen receptor gene 108 focal adhesion kinase 109 cox-2 expression 110 expression cyclooxygenase-2 111 interleukin-8 112 tnf alpha 113 factor binding protein 114 glutathione s transferase 115 igf binding protein 116 regulated kinase 117 platinum based chemotherapy 118 receptor antagonist polymorphism 119 hla g 120 leflunomide 121 cdna cloning 122 map kinase 123 metalloproteinase 124 receptor gene expression 125 growth factor system 126 interleukin-12 127 anti mullerian hormone 128 t helper cytokine 129 c kit 130 signal regulated 131 receptor beta 132 mrna expression 133 receptor polymorphism 134 androgen receptor 135 tissue inhibitor 136 expression cyclin b1 137 8-tetrachlorodibenzo p-dioxin 138 tgf 139 parathyroid hormone related 140 ifn 141 binding protein hur 142 protein coupled receptor 143 p-dioxin 144 xenograft 145 metalloproteinase-9 146 nitric oxide synthesis 147 interleukin receptor 148 tcdd 149 receptor gene 150 angiogenic growth factor 151 matrix metalloproteinase-9 152 ifn gamma 153 expression leptin receptor 154 igfbp 155 neurotrophin 156 cytokine mrna expression 157 releasing hormone 158 progesterone receptor gene 159 beta defensin 160 kinase inhibitor 161 cytochrome p450 162 protease activated 163 hla 164 igf binding 165 mammalian target rapamycin 166 receptor kinase 167 signal regulated kinase 168 activated protein kinase 169 protein-1 170 interleukin il 171 glucocorticoid receptor 172 tnf 173 interleukin-1 receptor antagonist 174 plasminogen activation system 175 nuclear receptor coregulator 176 cd4 t 177 cytokine 178 mitochondrial dna mutation 179 gonadotropin 180 growth factor binding 181 c t polymorphism 182 releasing hormone gnrh 183 tnf receptor i 184 integrin 185 decoy 186 cytokine production 187 protein kinase cdelta 188 growth factor beta 189 p53 protein 190 differentiated thyroid 191 cisplatin 192 releasing hormone receptor 193 cftr 194 receptor alpha beta 195 mrna 196 e selectin 197 human telomerase reverse 198 formalin fixed paraffin 199 phthalate 200 factor alpha interleukin-6 201 il-18 202 cadherin expression 203 activated protein 204 valproic acid 205 macrophage stimulating protein 206 tumor necrosis factor 207 hormone receptor 208 medroxyprogesterone 209 isoform 210 chronic intestinal pseudo 211 androgen receptor gene 212 luteinizing hormone surge 213 cyclin d1 protein 214 oxidative stress response 215 igfbp-1 216 delta t cell 217 protein expression 218 receptor alpha 219 transcription factor-1 220 selectin 221 midkine 222 histone 223 osteopontin 224 agonist therapy 225 heat shock protein 226 oxide synthase expression 227 pai-1 228 interleukin-1beta 229 growth factor beta-1 230 t helper 231 gnrh receptor gene 232 gnrh receptor 233 cytochrome p450 gene 234 tumor marker 235 costimulatory 236 alpha tnf 237 mcp-1 238 gelatin microsphere 239 regulation actin cytoskeleton 240 hormone related 241 gene protein 242 cytokine chemokine 243 alphavbeta6 integrin 244 prostaglandin receptor 245 probucol 246 beta catenin protein 247 tnf alpha il-2 248 telomerase 249 vitamin d 250 integrin expression 251 g protein coupled 252 shock protein 253 p21-activated kinase 254 cytochrome p450c17alpha 255 matrix metalloproteinase human 256 medroxyprogesterone acetate 257 ovarian mucinous 258 il-1 receptor 259 nitric oxide synthase 260 vegf a 261 p selectin 262 il-1 263 telomerase reverse transcriptase 264 cd4 t cell 265 growth factor igf 266 lovastatin 267 mannose binding lectin 268 interleukin 269 rna 270 metallothionein 271 hepatocellular 272 hydroxysteroid dehydrogenase 273 gadolinium 274 notch 275 thrombospondin-1 276 fusion protein 277 pth 278 pro angiogenic 279 fixed paraffin embedded 280 progesterone secretion 281 cytokine stimulated 282 antral follicle 283 endothelial nitric oxide 284 fluoxetine 285 tenascin 286 kinase b 287 mucinous tumor 288 binding protein-1 289 antioxidant 290 il-12 291 rt 292 kinase signaling 293 hormone related protein 294 steroid hormone receptor 295 androgen 296 il-13 297 lipid raft 298 sf-1 299 necrosis factor receptor 300 hydroxysteroid 301 hormone releasing hormone 302 ezrin 303 expression telomerase 304 tnf receptor 305 human telomerase 306 l selectin 307 oncoprotein 308 oxide synthase gene 309 expression erythropoietin 310 growth factor beta1 311 kinase pathway 312 lhrh 313 inducible nitric oxide 314 timp 315 metalloproteinase human 316 insulin receptor substrate-2 317 stress apoptosis 318 cyclin a 319 antiestrogen 320 growth differentiation factor 321 d1 protein 322 interferon 323 nk 324 interleukin-16 325 telomerase activity 326 decoy oligonucleotide 327 protein profiling 328 extracellular matrix protein 329 interleukin-1 330 estrogen metabolizing 331 insulin receptor 332 agonist treatment 333 synuclein 334 role mitogen activated 335 igf i 336 cannabinoid 337 paraoxonase-1 338 interferon gamma 339 erythropoietin receptor 340 c met 341 fibroblast growth factor 342 endoglin 343 sex hormone receptor 344 suppression matrix metalloproteinase 345 urokinase plasminogen 346 factor brx 347 role urocortin 348 tyrosine kinase 349 glucocorticoid 350 apoptotic protein 351 factor kappa b 352 expression prostaglandin 353 protein gene 354 nuclear factor kappa 355 il-1 beta 356 receptor il-1 357 cd4 358 oxidant antioxidant 359 alternatively 360 xenograft model 361 mapk signaling pathway 362 xenobiotic 363 igf 364 polybrominated 365 inhibitor apoptosis 366 cell collagen 367 effect peroxisome proliferator 368 e26 transformation specific 369 e cadherin expression 370 apolipoprotein a i 371 beta integrin 372 inhibitory factor 373 smooth muscle actin 374 endothelin-1 375 progesterone 376 ovarian mucinous tumor 377 luteal 378 integrin dependent 379 releasing hormone ghrh 380 mouse xenograft 381 protein kinase pathway 382 progestin 383 lysophosphatidic acid 384 calcium parathyroid 385 ahr 386 localization insulin growth 387 igf-1 388 paraffin embedded 389 progesterone production 390 il-1beta 391 target progestin 392 cytokine induced 393 lutein 394 insulin sensitivity 395 association glutathione 396 green fluorescent protein 397 annexin 398 connexin 399 collagen gel 400 estrogen 401 glutathione 402 ifn gamma tnf 403 cell adhesion molecule 404 sulindac 405 estradiol production 406 gamma tnf alpha 407 alteration expression dna 408 estrogen receptor expression 409 actin cytoskeleton 410 interleukin-10 411 receptor tyrosine kinase 412 insulin growth factor-1 413 tnf alpha induced 414 er 415 actinin 416 growth factor 417 plasminogen activator inhibitor 418 fgf 419 relaxin receptor 420 folate 421 alpha defensin 422 chemokine ligand 423 prolactin receptor 424 fluorescent protein 425 vimentin 426 lipoprotein metabolism 427 apolipoprotein 428 genistein 429 growth hormone releasing 430 receptor advanced glycation 431 topoisomerase 432 n acetyltransferase 433 glutathione peroxidase 434 neurokinin 435 immunoglobulin receptor 436 sulfotransferase 437 alloy 438 apolipoprotein a 439 retinoid 440 molecular basis 441 prb 442 exposure tcdd 443 mitogen 444 tnf beta 445 tet 446 luteinizing hormone releasing 447 minichromosome 448 expression insulin 449 factor receptor-1 450 cellular retinol binding 451 il-2 452 factor beta 453 epitope 454 alpha actinin 455 matrix metalloproteinase-13 456 tobacco 457 dopamine receptor 458 protein kinase inhibitor 459 beta tgf beta 460 3-dioxygenase 461 hormone receptor gene 462 reverse transcriptase 463 inhibitor cancer 464 mrna human 465 growth factor receptor 466 tunicamycin 467 receptor-2 468 meiotic 469 glutathione s-transferase 470 expression tnf alpha 471 murine 472 transferase 473 murine model 474 corticotropin releasing hormone 475 oxidative 476 interleukin-1 beta 477 patient thyroid 478 tgf beta1 479 urokinase plasminogen activator 480 co culture 481 renal phosphate 482 antiestrogenic 483 kinase 484 erythropoietin 485 adhesion molecule 486 m csf 487 receptor mrna Start A-Literature C-Literature B-list Filter Literature AB literature B-term BC literature Endometriosis cox-2 genes 1: Expression of COX-2 in intestinal endometriosis to: Tokyol C, et al. Int J Gynecol Pathol 2009;28:148-56.2010 Add to clipboard 2: Peritoneal fluid of patients with endometriosis promotes proliferation of endometrial stromal cells and induces COX-2 expression.2010 Add to clipboard 3: Effect of Yikun Neiyi Wan on the expression of aromatase P450, COX-2 , and ER related receptor in endometrial cells in vitro from patients with endometriosis .2009 Add to clipboard 4: Effect of oral contraceptives on vascular endothelial growth factor, Cox-2 and aromatase expression in the endometrium of uteri affected by myomas and associated pathologies.2008 Add to clipboard 5: Suppression of IL-1beta-induced COX-2 expression by trichostatin A (TSA) in human endometrial stromal cells.2007 Add to clipboard 6: COX-2 overexpression in peritoneal lesions is correlated with nonmenstrual chronic pelvic pain.2006 Add to clipboard 7: Nimesulide, a COX-2 inhibitor, does not reduce lesion size or number in a nude mouse model of endometriosis .2005 Add to clipboard 8: Is the dose to inhibit the COX-2 enzyme in nude mice also adequate in 'human' endometrial tissues?2005 Add to clipboard 9: Aromatase inhibitors and cyclooxygenase-2 (COX-2 ) inhibitors in endometriosis : new questions--old answers?2005 Add to clipboard 10: Analysis of cyclooxygenase-2 (COX-2 ) expression in different sites of endometriosis and correlation with clinico-pathological parameters.2004 Add to clipboard 11: The treatment with a COX-2 specific inhibitor is effective in the management of pain related to endometriosis .2004 Add to clipboard 12: COX-2 inhibitors and their role in gynecology.2002 Add to clipboard

个人分类: 知识发现|3302 次阅读|0 个评论

子宫内膜异位症研究国际文献分析 1928 - 2010年

xupeiyang 2010-8-21 20:23

http://news.sciencenet.cn/htmlnews/2010/8/236341.shtm 第375次香山科学会议聚焦内异症研究 http://baike.baidu.com/view/99734.htm?fr=ala0_1_1 　估计可能5%10%的妇女患有此病症，资料显示有越来越严重的趋势，在95年美国儿童健康及人类发展学院的召开的会议上，公认此疾病的发生率是10%，其中30%40%有疼痛的病证。亚洲人比欧洲人要多，92年的医学报告中指出，患者之中亚洲妇女占了51%，而欧洲妇女只有22%，在不孕妇女中30%40%的人患上了子宫内膜异位症。子宫内膜异位症并不是一个新发现的疾病，据有关报道古老的埃及和中国的文献都曾记载过这种病症。 http://www.gopubmed.org/web/gopubmed/WEB1lOWEB10O00h00100090000100h001000j100300.y 16,985 documents semantically analyzed top author statistics 1 2 3 4 Top Years Publications 2009 857 2008 732 2007 690 2010 671 2006 648 2005 597 2003 592 2001 552 2004 549 2002 519 1998 448 2000 446 1995 436 1990 430 1996 428 1994 426 1999 422 1991 420 1993 414 1997 395 1 2 3 4 1 2 3 ... 7 Top Countries Publications USA 2,794 Japan 1,047 Italy 842 United Kingdom 771 France 544 China 509 Germany 494 Canada 311 Belgium 294 Australia 256 Spain 221 Brazil 194 Turkey 188 Taiwan 181 Greece 144 Netherlands 137 South Korea 135 Poland 101 India 89 Austria 85 1 2 3 ... 7 1 2 3 ... 60 Top Cities Publications Milan 254 Paris 216 Tokyo 206 Boston 172 London 158 Chicago 140 Leuven 133 New Haven 133 Rome 125 New York 125 Brussels 124 Beijing 119 Taipei 97 Seoul 89 Houston 87 Cleveland 86 Oxford 76 Sydney 69 Quebec City 68 Baltimore 66 1 2 3 ... 60 1 2 3 ... 93 Top Journals Publications Fertil Steril 1,653 Hum Reprod 648 Am J Obstet Gynecol 598 Obstet Gynecol 447 J Reprod Med 278 Gynecol Obstet Invest 209 Akush Ginekol (mosk) 202 Ginekol Pol 199 Eur J Obstet Gyn R B 197 Zhonghua Fu Chan Ke Za Zhi 176 Zentralbl Gynakol 166 Acta Obstet Gyn Scan 163 Nippon Sanka Fujinka Gakkai Zasshi 145 Gynecol Oncol 144 Int J Gynecol Obstet 143 J Am Assoc Gynecol Laparosc 141 J Minim Invasive Gynecol 140 Am J Reprod Immunol 126 Minerva Ginecol 124 Gynecol Endocrinol 121 1 2 3 ... 93 1 2 3 ... 547 Top Terms Publications Endometriosis 16,677 Humans 14,445 Adult 8,290 Patients 6,376 Women 5,764 Middle Aged 3,565 Diagnosis 3,404 Laparoscopy 3,001 Evaluation Studies as Topic 2,584 Infertility 2,545 Endometrium 2,417 Pregnancy 2,328 Surgery 2,175 Infertility, Female 2,067 Tissues 1,986 Hormones 1,948 Laparoscopes 1,790 Ovarian Neoplasms 1,786 Fertility 1,684 Uterine Neoplasms 1,680 1 2 3 ... 547 1 2 3 ... 1983 Top Authors Publications Vercellini P 102 Donnez J 97 Fedele L 87 Arici A 82 Kennedy S 82 Koninckx P 73 Chapron C 65 Brosens I 65 Crosignani P 64 Dmowski W 64 Olive D 63 Nezhat F 61 Nezhat C 59 Vigan P 57 Canis M 57 Taketani Y 54 Barlow D 54 Bianchi S 53 Somigliana E 51 Rock J 50 1 2 3 ... 1983 publications over time

个人分类: 女性健康|3046 次阅读|0 个评论

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