# 编者信息 熊荣川 明湖实验室 xiongrongchuan@126.com http://blog.sciencenet.cn/u/Bearjazz A measure of genetic distance (D) based on the identity of genes between populations is formulated. It is defined as D = -logeI, where I is the normalized identity of genes between two populations. This genetic distance measures the accumulated allele differences per locus. If the rate of gene substitution per year is constant, it is linearly related to the divergence time between populations under sexual isolation . It is also linearly related to geographical distance or area in some migration models. Since D is a measure of the accumulated number of codon differences per locus, it can also be estimated from data on amino acid sequences in proteins even for a distantly related species. Thus, if enough data are available, genetic distance between any pair of organisms can be measured in terms of D. This measure is applicable to any kind of organism without regard to ploidy or mating scheme. 提出了一种基于群体间基因一致性的遗传距离（ D ）度量方法。其公式定义为 D = -logeI ，其中 I 是两个种群之间基因的标准化一致性。这个遗传距离测量每个基因座累积的等位基因差异。如果每年的基因替换率是恒定的，那么它与性隔离下种群之间的分化时间呈线性相关。在一些迁移模型中，它也与地理距离或区域（大小）呈线性关系。由于 D 是每个基因座密码子差异累积数量的一个度量，因此它也可以基于蛋白质中氨基酸序列的数据来估计，即使对于远亲物种也是如此。因此，如果有足够的数据，任何一对生物体之间的遗传距离都可以用 D 来测量。这种测量方法适用于任何一种生物体，而不考虑染色体倍性或交配机制。 Nei M . Genetic Distance between Populations . The American Naturalist, 1972, 106(949):283-292.
标签: 遗传距离
