《古植物学的故事》（学习资料） 《维管植物比较形态学》作者之一Ernest M. Gifford（1920--2006） Ernest M. Gifford（1920--2006）是Adriance S. Foster (1901--1973)的学生。E. M. Gifford于1949年从 加州大学 Berkeley 分校植物系获得博士学位，毕业后留在该系工作， 1987 年退休。 E. M. Gifford自1975年至1979年担任《美国植物学报》主编，1982年担任美国植物学会会长。 孙启高 2010年12月25日 -------------------- 资料出处： http://www.universityofcalifornia.edu/senate/inmemoriam/ernestmgifford.htm IN MEMORIAM Ernest M. Gifford Professor Emeritus Plant Biology UC Davis 1920 ndash; 2006 Ernest Gifford was born in 1920; as a young boy in Riverside, California, Ernest Gifford made the acquaintance of Dr. Edmund C. Jaeger, a biologist at Riverside Junior College. Jaeger was a student and teacher of the desert flora and fauna, and young Gifford spent much time in Jaeger's company. From this sprung his lifelong interest in plants, so when he graduated from Riverside Polytechnic High School in 1938, he knew what he wanted to domdash;study plants. The place to do that was UC Berkeley, where he had a choice of accepting a football scholarship or an academic scholarship. Fortunately for botany and for generations of UC Davis undergraduate and graduate students, he decided to forego athletics and pursue his longstanding interest, as a botany major. While at Berkeley, Gifford participated in Reserve Officers' Training Corps (ROTC), as did many College men of his generation. Upon graduation in 1942 with an A.B. degree, he received a commission in the U.S. Army where he served in the 14th Armored Infantry Division as an officer in Europe as part of Patton's army, and saw action in the Battle of the Bulge. Gifford served initially as a tank commander, and later, in graves registration. He reached the rank of major and was awarded the Bronze Star. At the time of his demobilization in1946, Gifford considered making a career of the military, but instead returned to Berkeley to pursue a Ph.D. degree in botany, although he remained in the Army Reserves until 1973, when he retired as a full colonel. Following completion of his Ph.D. in 1949, Gifford joined the faculty of the Department of Botany as an assistant professor and assistant botanist in the Agricultural Experiment Station. He progressed through the ranks and achieved the level of professor and botanist in the Agriculture and Environmental Sciences in 1962. Gifford retired in 1987 , although he returned on recall status for five more years to teach his upper division class in plant morphology. Gifford was an internationally renowned botanist, with interests in plant anatomy, morphology, and cytology. The main focus of his research was the formative region of the plant body that gives rise to leaves, the stem and to flowers, the apical meristem. He and his students and co-workers investigated the cellular and chemical changes that accompany the transition from the vegetative phase to the reproductive phase, particularly in the basal flowering plants and also in conifers . Prof. Gifford was a pioneer in the use of radioisotope techniques to observe and study DNA synthesis in plant nuclei. In 1958, Partanan and Gifford published a seminal paper in the journal Nature , showing applications of autoradiographic techniques to studies of shoot apices. In 1959, colleague Ralph Stocking and Gifford showed the first direct observation of radioactive thymidine (a precursor of DNA) incorporation into algal chloroplasts, the first evidence of DNA in chloroplasts. The next year, Gifford demonstrated the incorporation of tritiated thymidine into nuclei of shoot apical meristems and predicted the usefulness of this technique for information about sites of mitotic activity in growing shoot tips. Professor Gifford collaborated with many other departmental and campus colleagues in both fundamental and mission-oriented research. Weed science and herbicide physiology were strengths of the Botany Department, and Gifford and his students investigated effects of several herbicides and other growth regulators on plant growth and development, as well as virus effects on grape vines. With co-workers, Gifford worked to free the French Columbard grapevine from a devastating virus by heat therapy and tissue culture. Once free of the virus, the variety was propagated vegetatively and made available to growers. Somewhat later in his career, Gifford became interested in the cytology and ultrastructure of reproductive cells of non-flowering seed plants, such as the swimming sperms of Ginkgo. Many of his graduate students conducted research on apical meristems of non-seed plants, assessing structural and functional questions in ferns, horsetails, and clubmosses. In addition to his more usual academic pursuits, Gifford assisted on several criminal cases in which plant anatomy and morphology provided information to help solve the crimes. One particularly noteworthy case was the 1971 murder of 25 farm workers by Juan Corona near Yuba City. Gifford and Prof. David Bayer, his weed physiologist colleague, visited the orchard gravesites to help determine when the plants growing on the graves had germinated so authorities could determinate when and in what order the workers had been killed. They collected plants from the burial sites for analysis and subsequent identification by the UCD Herbarium. Professor Gifford was active in campus and professional society leadership and service, and received many honors in his lifetime. He was chair of the Botany Department from 1963 to 1967 and 1974 to 1978. He was co-author with his former UC Berkeley major professor, Adriannce S. Foster, of the widely used text Morphology and Evolution of Vascular Plants, author and co-author of more than 100 publications, and a member of numerous scientific societies. He was a National Research Council fellow at Harvard in 1956 and a Fulbright research scholar in France in 1966. He received a Guggenheim award and was also a North Atlantic Treaty Organization (NATO) postdoctoral fellow, also in France. He received the Davis Division Academic Senate Distinguished Teaching Award in 1986, a Botanical Society of America Merit Award in 1981 , and a BSA Centennial Award in 2006. From 1975 to 1979, he served as editor-in-chief of The American Journal of Botany, and in 1982, the AS President of the Botanical Society of America. Professor Gifford was born January 17, 1920 in Riverside, Calif., to Ernest M. Gifford, Sr. and Mildred Campbell Gifford. He died June 14, 2006, in Davis, from complications of Alzheimer's disease. He is survived by his wife of 63 years, Jean Duncan Gifford, his daughter, Jeanette Lewis and her husband Jonathan of Davis, and his grandson, Aaron Lewis of New York City. The family encourages friends and colleagues to remember him by visiting the Ernest M. Gifford Cycad Garden in front of Storer Hall on the UCD campus, which was dedicated in his honor in September 2005. Donations in memoriam may be made to the UC Davis Foundation, One Shields Avenue, Davis, CA 95616 designating the Arboretum Endowment or Botanical Conservatory Endowment funds. Judy Jernstedt Tom Rost Michael Barbour -----------
加拿大安大略癌症研究所 高级科学家 Ernest A. McCulloch 获奖原因 因在 DNA 因发现干细胞和开发诱导多能干细胞而获奖 http://scholar.google.com.hk/scholar?hl=enq=EA+McCulloch+++stem+cells+btnG=Searchas_sdt=2000as_ylo=as_vis=0 A stochastic model of stem cell proliferation, based on the growth of spleen colony-forming cells pnas.org JE Till, EA McCulloch , L Siminovitch - Proceedings of the National , 1964 - ncbi.nlm.nih.gov Normal mammalian hemopoietic tissue produces a continuous supply of dif- ferentiated blood cells whose functions are essential for life. These functional cells have limited life spans and are incapable of self-renewal. For example, erythro- cytes lack nuclei and thus, though ... Cited by 565 - Related articles - All 11 versions Physical separation of hemopoietic stem cells from cells forming colonies in culture RG Worton, EA McCulloch , JE - Journal of Cellular , 1969 - interscience.wiley.com ABSTRACT Mouse bone marrow cells in suspension were separated into a number of fractions on the basis of cell density by equilibrium density gradient centrifugation, or on the basis of cell size by velocity sedimentation. After each type of separation, the cells from the various ... Cited by 359 - Related articles - All 2 versions Hemopoietic stem cell differentiation. JE Till, EA McCulloch - Biochimica et biophysica acta, 1980 - ncbi.nlm.nih.gov 1: Biochim Biophys Acta. 1980 Nov 26;605(4):431-59. Hemopoietic stem cell differentiation. Till JE, McCulloch EA . Publication Types: Research Support, Non-US Gov't; Review. Mesh Terms: Animals; Antigens, Surface/immunology; Cell Differentiation*; Cell Division; ... Cited by 242 - Related articles - All 3 versions Mouse myeloma tumor stem cells : a primary cell culture assay. Park, DE Bergsagel, EA McCulloch - Journal of the National , 1971 - ncbi.nlm.nih.gov ... Park CH, Bergsagel DE, McCulloch EA . PMID: 5115909 MeSH Terms: Animals; Cell Count; Cells */radiation effects; Centrifugation; Culture Media; Culture Techniques*; Hematopoietic Stem Cells /radiation effects; Injections; ... Cited by 246 - Related articles The distribution of colony-forming cells among spleen colonies utoronto.ca L Siminovitch, EA McCulloch , - Journal of Cellular and , 1963 - tspace.library.utoronto.ca ... Gurney, CW, LG Lajtha and R. Oliver 1962 A method for investigation of stem - cell kinetics. Brit. J. Haemat., 8: 461-466. McCulloch , EA , and JE Till 1962 The sensitivity of cells from normal mouse bone marrow to gamrna radiation in vitro and in vivo. ... Cited by 511 - Related articles - View as HTML - All 5 versions The effect of differing demands for blood cell production on DNA synthesis by hemopoietic colony-forming cells of mice hematologylibrary.org Becker, EA McCulloch , L Siminovitch, JE - , 1965 - bloodjournal.hematologylibrary.org Page 1. The Effect of Differing Demands for Blood Cell Production on DNA Synthesis by Hemopoietic Colony-Forming Cells of Mice By A. J. BECKER, EA MCCULLOCH , L. SIMIN0vITcH AND J. E. TILL ... EA N'IcCUL- ... Page 3. 298 BECKER, MC CULLOCH , SIMINOVITCH AND TILL ... Cited by 483 - Related articles - All 8 versions Cytological evidence for a relationship between normal hematopoietic colony-forming cells and cells of the lymphoid system rupress.org , JE Till, L Siminovitch, EA McCulloch - The Journal of , 1968 - jem.rupress.org ... BY AM WU,$ BM, JE TILL, PH.D., L. SIMINOVITCH, ProD., Am) EA McCULLOCH , MD (From the Departments of Medicine and ... mouse hematopoietic colony- forming stem ceils can differentiate along both erythropoietic and granulocytic lines (1). This class of stem cells is present ... Cited by 308 - Related articles - All 11 versions Stem cells in normal and leukemic hemopoiesis (Henry Stratton Lecture, 1982) hematologylibrary.org EA McCulloch - Blood, 1983 - bloodjournal.hematologylibrary.org CELLULAR ORGANIZATION IN HEMATOPOIESIS Myelopoiesis The myeloid component of hemopoiesis is a typical cell renewal system.' It consists of three classes of cells that differ in their functional capacities (Fig. I). First, pluripotent stem cells are capable of self-renewal ... Cited by 122 - Related articles - All 5 versions Physical separation of hemopoietic stem cells differing in their capacity for self-renewal rupress.org RG Worton, EA McCulloch , JE Till - Journal of Experimental , 1969 - jem.rupress.org Two key properties of hemopoietic stem cells are their capacity for self- renewal and their capacity for differentiation. The stem ceils in mouse hemo- poietic tissues that may be detected by their ability to form macroscopic splenic colonies possess both these properties, but express ... Cited by 99 - Related articles - All 8 versions Stem cells in normal and leukemic hemopoiesis EA McCulloch - Blood, 1983 Cited by 122 - Related articles Evidence for a relationship between mouse hemopoietic stem cells and cells forming colonies in culture pnas.org AM Wu, L Siminovitch, JE Till, EA McCulloch - Proceedings of the National , 1968 - JSTOR The spleen colony technique' has proved to be a useful tool for the enumera- tion of hemopoietic stem cells in the mouse and for the study of their properties. However, since the method depends on colony formation in the spleens of heavily irradiated' or genetically anemic2 mice, it ... Cited by 84 - Related articles - All 8 versions A cytological study of the capacity for differentiation of normal hemopoietic colony-forming cells Till, L Siminovitch, EA McCulloch - Journal of Cellular , 1967 - interscience.wiley.com ... even with- out irradiation, support the growth of nor- mal hemopoietic colony-forming cells ( Mc - Culloch et d ... 182 A. M. WU, J. E. TILL, L. SIMINOVITCH AND EA McCULLOCH ... finding provides cyto- logicai proof that the original marrow sus- pension contained stem cells able to ... Cited by 224 - Related articles - All 2 versions Growth factors influence the sensitivity of leukemic stem cells to cytosine arabinoside in culture hematologylibrary.org , C Wang, S Minkin, EA McCulloch - , 1989 - bloodjournal.hematologylibrary.org ... Arabinoside in Culture By Jun Miyauchi. CoIm A. Kelleher, Chen Wang, Salomon Minkin, and Ernest A. McCulloch We have proposed that the blasts in acute myeloblastic leukemia (AML) are renewal populations maintained by a small subpopulation of stem cells . ... Cited by 77 - Related articles - All 5 versions Colony formation by normal and leukemic human marrow cells in culture: effect of conditioned medium from human leukocytes hematologylibrary.org Iscove, JS Senn, JE Till, EA McCulloch - Blood, 1971 - bloodjournal.hematologylibrary.org ... 1 Colony Formation by Normal and Leukemic Human Marrow Cells in Culture: Effect of Conditioned Medium From Human Leukocytes By NN IscovE, J. S. SENN, J. E. TILL AND EA MCCULLOCH Conditioned medium obtained from from the marrow of patients with acute ... Cited by 428 - Related articles - View as HTML - All 4 versions Self-renewal in culture of proliferative blast progenitor cells in acute myeloblastic leukemia hematologylibrary.org RN Buick, MD Minden, EA McCulloch - Blood, 1979 - bloodjournal.hematologylibrary.org ... to Dr. EA McCulloch . Ontario Cancer Institute, 500 Sherbourne Street. Toronto, Ontario M4X / K9, Canada. 1979 by Grune Stratton, Inc. 0006-4971/79/5402-00i2$0l.00/0 Page 2. 96 BUICK. MINDEN, AND McCULLOCH since this property provides individual stem cells with ... Cited by 175 - Related articles - All 4 versions The effect of erythropoietic stimulation on the hemopoietic colony-forming cells of mice hematologylibrary.org WR Bruce, EA McCulloch - Blood, 1964 - bloodjournal.hematologylibrary.org ... Hemopoietic Colony-forming Cells of Mice By WR BRUCE AND EA MCCULLOCH IT IS generally assumed (see for example, ref. ... the existence of a close relationship between colony-forming cells and the stem cells of the erythroid series. ... 218 BRUCE AND MC CULLOCH ... Cited by 163 - Related articles - All 4 versions The effects of three recombinant growth factors, IL-3, GM-CSF, and G-CSF, on the blast cells of acute myeloblastic leukemia maintained in short-term suspension hematologylibrary.org , MD Minden, S Minkin, EA McCulloch - , 1987 - bloodjournal.hematologylibrary.org ... Maintained in Short-Term Suspension Culture By Jun Miyauchi, CoIm A. Kelleher, Yu-Chung Yang, Gordon G. Wong, Steven C. Clark, Mark D. Minden, Salomon Minkin, and Ernest A. McCulloch The blast stem cells of acute myeloblastic leukemia (AML) ... Cited by 139 - Related articles - All 5 versions The cellular basis of the genetically determined hemopoietic defect in anemic mice of genotype Sl/Sld hematologylibrary.org EA McCulloch , L Siminovitch, JE Till, ES - , 1965 - bloodjournal.hematologylibrary.org ... 25, 1964. EA MCCULLOCH : Associate Professor, Department of Medical Biophysics, University ... extremely different. In a previous study ( McCulloch et al.5) the spleen-colony assay for hemo- poietic stem cells was used to investigate certain aspects of the effects of the ... Cited by 261 - Related articles - All 6 versions Direct evidence for the participation of bcl-2 in the regulation by retinoic acid of the Ara-C sensitivity of leukemic stem cells ZB Hu, MD Minden, EA McCulloch - Leukemia, 1995 - cat.inist.fr All-trans retinoic acid (ATRA) increases the sensitivity of AML blast cells to cytosine arabinoside (Ara-C) or daunorubicin (DNR) when ATRA is given after drug. We have proposed that down-regulation of bcl-2 is part of the mechanism by which ATRA regulates drug ... Cited by 53 - Related articles - BL Direct - All 3 versions Spleen-colony formation in anemic mice of genotype WW utoronto.ca EA McCulloch , L Siminovitch, JE Till - Science, 1964 - sciencemag.org ... Our results sup- port the suggestion (18) that the stem cells responding to erythropoietin (19) are not identical with the stem cells that give rise to spleen colonies. EA MCCULLOCH L. SIMINOVITCH JE TILL Department of Medical Biophysics, University of Toronto, and ... Cited by 271 - Related articles - All 6 versions
标签: Ernest
