加拿大安大略癌症研究所 高级科学家 Ernest A. McCulloch 获奖原因 因在 DNA 因发现干细胞和开发诱导多能干细胞而获奖 http://scholar.google.com.hk/scholar?hl=enq=EA+McCulloch+++stem+cells+btnG=Searchas_sdt=2000as_ylo=as_vis=0 A stochastic model of stem cell proliferation, based on the growth of spleen colony-forming cells pnas.org JE Till, EA McCulloch , L Siminovitch - Proceedings of the National , 1964 - ncbi.nlm.nih.gov Normal mammalian hemopoietic tissue produces a continuous supply of dif- ferentiated blood cells whose functions are essential for life. These functional cells have limited life spans and are incapable of self-renewal. For example, erythro- cytes lack nuclei and thus, though ... Cited by 565 - Related articles - All 11 versions Physical separation of hemopoietic stem cells from cells forming colonies in culture RG Worton, EA McCulloch , JE - Journal of Cellular , 1969 - interscience.wiley.com ABSTRACT Mouse bone marrow cells in suspension were separated into a number of fractions on the basis of cell density by equilibrium density gradient centrifugation, or on the basis of cell size by velocity sedimentation. After each type of separation, the cells from the various ... Cited by 359 - Related articles - All 2 versions Hemopoietic stem cell differentiation. JE Till, EA McCulloch - Biochimica et biophysica acta, 1980 - ncbi.nlm.nih.gov 1: Biochim Biophys Acta. 1980 Nov 26;605(4):431-59. Hemopoietic stem cell differentiation. Till JE, McCulloch EA . Publication Types: Research Support, Non-US Gov't; Review. Mesh Terms: Animals; Antigens, Surface/immunology; Cell Differentiation*; Cell Division; ... Cited by 242 - Related articles - All 3 versions Mouse myeloma tumor stem cells : a primary cell culture assay. Park, DE Bergsagel, EA McCulloch - Journal of the National , 1971 - ncbi.nlm.nih.gov ... Park CH, Bergsagel DE, McCulloch EA . PMID: 5115909 MeSH Terms: Animals; Cell Count; Cells */radiation effects; Centrifugation; Culture Media; Culture Techniques*; Hematopoietic Stem Cells /radiation effects; Injections; ... Cited by 246 - Related articles The distribution of colony-forming cells among spleen colonies utoronto.ca L Siminovitch, EA McCulloch , - Journal of Cellular and , 1963 - tspace.library.utoronto.ca ... Gurney, CW, LG Lajtha and R. Oliver 1962 A method for investigation of stem - cell kinetics. Brit. J. Haemat., 8: 461-466. McCulloch , EA , and JE Till 1962 The sensitivity of cells from normal mouse bone marrow to gamrna radiation in vitro and in vivo. ... Cited by 511 - Related articles - View as HTML - All 5 versions The effect of differing demands for blood cell production on DNA synthesis by hemopoietic colony-forming cells of mice hematologylibrary.org Becker, EA McCulloch , L Siminovitch, JE - , 1965 - bloodjournal.hematologylibrary.org Page 1. The Effect of Differing Demands for Blood Cell Production on DNA Synthesis by Hemopoietic Colony-Forming Cells of Mice By A. J. BECKER, EA MCCULLOCH , L. SIMIN0vITcH AND J. E. TILL ... EA N'IcCUL- ... Page 3. 298 BECKER, MC CULLOCH , SIMINOVITCH AND TILL ... Cited by 483 - Related articles - All 8 versions Cytological evidence for a relationship between normal hematopoietic colony-forming cells and cells of the lymphoid system rupress.org , JE Till, L Siminovitch, EA McCulloch - The Journal of , 1968 - jem.rupress.org ... BY AM WU,$ BM, JE TILL, PH.D., L. SIMINOVITCH, ProD., Am) EA McCULLOCH , MD (From the Departments of Medicine and ... mouse hematopoietic colony- forming stem ceils can differentiate along both erythropoietic and granulocytic lines (1). This class of stem cells is present ... Cited by 308 - Related articles - All 11 versions Stem cells in normal and leukemic hemopoiesis (Henry Stratton Lecture, 1982) hematologylibrary.org EA McCulloch - Blood, 1983 - bloodjournal.hematologylibrary.org CELLULAR ORGANIZATION IN HEMATOPOIESIS Myelopoiesis The myeloid component of hemopoiesis is a typical cell renewal system.' It consists of three classes of cells that differ in their functional capacities (Fig. I). First, pluripotent stem cells are capable of self-renewal ... Cited by 122 - Related articles - All 5 versions Physical separation of hemopoietic stem cells differing in their capacity for self-renewal rupress.org RG Worton, EA McCulloch , JE Till - Journal of Experimental , 1969 - jem.rupress.org Two key properties of hemopoietic stem cells are their capacity for self- renewal and their capacity for differentiation. The stem ceils in mouse hemo- poietic tissues that may be detected by their ability to form macroscopic splenic colonies possess both these properties, but express ... Cited by 99 - Related articles - All 8 versions Stem cells in normal and leukemic hemopoiesis EA McCulloch - Blood, 1983 Cited by 122 - Related articles Evidence for a relationship between mouse hemopoietic stem cells and cells forming colonies in culture pnas.org AM Wu, L Siminovitch, JE Till, EA McCulloch - Proceedings of the National , 1968 - JSTOR The spleen colony technique' has proved to be a useful tool for the enumera- tion of hemopoietic stem cells in the mouse and for the study of their properties. However, since the method depends on colony formation in the spleens of heavily irradiated' or genetically anemic2 mice, it ... Cited by 84 - Related articles - All 8 versions A cytological study of the capacity for differentiation of normal hemopoietic colony-forming cells Till, L Siminovitch, EA McCulloch - Journal of Cellular , 1967 - interscience.wiley.com ... even with- out irradiation, support the growth of nor- mal hemopoietic colony-forming cells ( Mc - Culloch et d ... 182 A. M. WU, J. E. TILL, L. SIMINOVITCH AND EA McCULLOCH ... finding provides cyto- logicai proof that the original marrow sus- pension contained stem cells able to ... Cited by 224 - Related articles - All 2 versions Growth factors influence the sensitivity of leukemic stem cells to cytosine arabinoside in culture hematologylibrary.org , C Wang, S Minkin, EA McCulloch - , 1989 - bloodjournal.hematologylibrary.org ... Arabinoside in Culture By Jun Miyauchi. CoIm A. Kelleher, Chen Wang, Salomon Minkin, and Ernest A. McCulloch We have proposed that the blasts in acute myeloblastic leukemia (AML) are renewal populations maintained by a small subpopulation of stem cells . ... Cited by 77 - Related articles - All 5 versions Colony formation by normal and leukemic human marrow cells in culture: effect of conditioned medium from human leukocytes hematologylibrary.org Iscove, JS Senn, JE Till, EA McCulloch - Blood, 1971 - bloodjournal.hematologylibrary.org ... 1 Colony Formation by Normal and Leukemic Human Marrow Cells in Culture: Effect of Conditioned Medium From Human Leukocytes By NN IscovE, J. S. SENN, J. E. TILL AND EA MCCULLOCH Conditioned medium obtained from from the marrow of patients with acute ... Cited by 428 - Related articles - View as HTML - All 4 versions Self-renewal in culture of proliferative blast progenitor cells in acute myeloblastic leukemia hematologylibrary.org RN Buick, MD Minden, EA McCulloch - Blood, 1979 - bloodjournal.hematologylibrary.org ... to Dr. EA McCulloch . Ontario Cancer Institute, 500 Sherbourne Street. Toronto, Ontario M4X / K9, Canada. 1979 by Grune Stratton, Inc. 0006-4971/79/5402-00i2$0l.00/0 Page 2. 96 BUICK. MINDEN, AND McCULLOCH since this property provides individual stem cells with ... Cited by 175 - Related articles - All 4 versions The effect of erythropoietic stimulation on the hemopoietic colony-forming cells of mice hematologylibrary.org WR Bruce, EA McCulloch - Blood, 1964 - bloodjournal.hematologylibrary.org ... Hemopoietic Colony-forming Cells of Mice By WR BRUCE AND EA MCCULLOCH IT IS generally assumed (see for example, ref. ... the existence of a close relationship between colony-forming cells and the stem cells of the erythroid series. ... 218 BRUCE AND MC CULLOCH ... Cited by 163 - Related articles - All 4 versions The effects of three recombinant growth factors, IL-3, GM-CSF, and G-CSF, on the blast cells of acute myeloblastic leukemia maintained in short-term suspension hematologylibrary.org , MD Minden, S Minkin, EA McCulloch - , 1987 - bloodjournal.hematologylibrary.org ... Maintained in Short-Term Suspension Culture By Jun Miyauchi, CoIm A. Kelleher, Yu-Chung Yang, Gordon G. Wong, Steven C. Clark, Mark D. Minden, Salomon Minkin, and Ernest A. McCulloch The blast stem cells of acute myeloblastic leukemia (AML) ... Cited by 139 - Related articles - All 5 versions The cellular basis of the genetically determined hemopoietic defect in anemic mice of genotype Sl/Sld hematologylibrary.org EA McCulloch , L Siminovitch, JE Till, ES - , 1965 - bloodjournal.hematologylibrary.org ... 25, 1964. EA MCCULLOCH : Associate Professor, Department of Medical Biophysics, University ... extremely different. In a previous study ( McCulloch et al.5) the spleen-colony assay for hemo- poietic stem cells was used to investigate certain aspects of the effects of the ... Cited by 261 - Related articles - All 6 versions Direct evidence for the participation of bcl-2 in the regulation by retinoic acid of the Ara-C sensitivity of leukemic stem cells ZB Hu, MD Minden, EA McCulloch - Leukemia, 1995 - cat.inist.fr All-trans retinoic acid (ATRA) increases the sensitivity of AML blast cells to cytosine arabinoside (Ara-C) or daunorubicin (DNR) when ATRA is given after drug. We have proposed that down-regulation of bcl-2 is part of the mechanism by which ATRA regulates drug ... Cited by 53 - Related articles - BL Direct - All 3 versions Spleen-colony formation in anemic mice of genotype WW utoronto.ca EA McCulloch , L Siminovitch, JE Till - Science, 1964 - sciencemag.org ... Our results sup- port the suggestion (18) that the stem cells responding to erythropoietin (19) are not identical with the stem cells that give rise to spleen colonies. EA MCCULLOCH L. SIMINOVITCH JE TILL Department of Medical Biophysics, University of Toronto, and ... Cited by 271 - Related articles - All 6 versions
标签: 生理学或医学
