设为首页收藏本站
开启辅助访问 切换到宽版

科学网

 找回密码
  注册
科学网 › 标签 › 肺腺癌

tag 标签: 肺腺癌

相关帖子

 版块 作者 回复/查看 最后发表

没有相关内容

相关日志

肺腺癌与JNK研究的知识发现
xupeiyang 2010-9-27 11:19
JNK信号转导通路是MAPK通路的一重要分支，它在细胞周期、生产、凋亡和细胞应激等多种生理和病理过程中起重要作用。 JNK信号转导通路是1991年发现的一类MAPK通路。 　　JNK蛋白激酶由3个基因编码，jnk 1和jnk 2基因在全身广泛表达，而jnk 3呈限制性表达，仅见于脑、心脏和睾丸 J。在未受刺激的细胞中，JNK主要存在于胞质内，但核内也有一定分布。在受到刺激后， K迅速而显著地聚积于核内，并导致相应基因表达改变。JNK基因通过选择性剪接而产生10种JNK形式，JNK基因编码的蛋白具有或无一COOH末端，结果产生46 kDa和54 kDa两种蛋白。第二种剪接是选择性编码JNK功能区两个外显子中的一个，但只限于jnk 1和jnk 2基因。不同组织发出不同指令，通过选择性剪接，JNK改变停泊位点与底物的结合能力，从而决定作用底物的特异性 。 知识发现与研究论文： http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi Start A-Literature C-Literature B-list Filter Literature A-query: Lung Adenocarcinoma C-query: Oncogenic Mutant Kinases The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 12 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here . The results of this search are saved under id # 8440 and can be accessed from the start page after you leave this session. There are 582 terms on the current B-list ( 358 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin. To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms. http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/show_sentences.cgi Start A-Literature C-Literature B-list Filter Literature AB literature B-term BC literature Lung Adenocarcinoma jnk Oncogenic Mutant Kinases 1: The JNK inhibitor SP600125 enhances dihydroartemisinin-induced apoptosis by accelerating Bax translocation into mitochondria in human lung adenocarcinoma cells.2010 Add to clipboard 2: Gefitinib-induced epidermal growth factor receptor (EGFR)-independent keratinocyte apoptosis is mediated by the JNK- activation pathway.2010 Add to clipboard 3: Novel indoloquinoline derivative, IQDMA, induces G(2)/M phase arrest and apoptosis in A549 cells through JNK/ p38 MAPK signaling activation.2009 Add to clipboard 4: Co-opted JNK/ SAPK signaling in Wnt/beta-catenin-induced tumorigenesis.2008 Add to clipboard 5: Sodium 4-phenylbutyrate induces apoptosis of human lung carcinoma cells through activating JNK pathway.2004 Add to clipboard 6: The roles of JNK and apoptotic signaling pathways in PEITC-mediated responses in human HT-29 colon adenocarcinoma cells.2003 Add to clipboard 7: Roles of JNK, p38 and ERK mitogen-activated protein kinases in the growth inhibition and apoptosis induced by cadmium.2000 Add to clipboard 8: Activation of JNK, p38 and ERK mitogen-activated protein kinases by chromium(VI) is mediated through oxidative stress but does not affect cytotoxicity.2000 Add to clipboard
个人分类: 肿瘤研究|3531 次阅读|0 个评论
肺腺癌的基因知识发现
xupeiyang 2010-9-27 10:55
我国研究发现非吸烟肺腺癌人群中关键致癌基因突变谱 http://news.sciencenet.cn/htmlnews/2010/9/238016.shtm http://jco.ascopubs.org/content/early/2010/09/17/JCO.2010.29.6038.abstract?sid=835dd89f-9fb8-451b-90e4-07ba755d8419 知识发现平台与检索分析用词： http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi Start A-Literature C-Literature B-list Filter Literature A-query: Lung Adenocarcinoma C-query: Oncogenic Mutant Kinases The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 12 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here . The results of this search are saved under id # 8440 and can be accessed from the start page after you leave this session. There are 582 terms on the current B-list ( 358 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin. To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms. job id # 8440 started Sun Sep 26 23:11:41 2010 Max_citations: 50000 Stoplist: /var/www/html/arrowsmith_uic/data/stopwords_pubmed Ngram_max: 3 8440 Search ARROWSMITH A A_query_raw: Lung Adenocarcinoma Sun Sep 26 23:11:59 2010 A query = Lung Adenocarcinoma started Sun Sep 26 23:12:00 2010 A query resulted in 32435 titles 8440 Search ARROWSMITH C C_query_raw: Oncogenic Mutant Kinases Sun Sep 26 23:12:40 2010 C: Oncogenic Mutant Kinases 995 A: pubmed_query_A 32435 AC: ( Lung Adenocarcinoma ) AND ( Oncogenic Mutant Kinases ) 12 C query = Oncogenic Mutant Kinases started Sun Sep 26 23:12:41 2010 C query resulted in 995 titles A AND C query resulted in 12 titles 3741 B-terms ready on Sun Sep 26 23:13:48 2010 Sem_filter: Genes Molecular Sequences, and Gene Protein Names 582 B-terms left after filter executed Sun Sep 26 23:16:46 2010 这些基因相关的知识隐含在文献中，对科研很有参考价值。 B-list on Sun Sep 26 23:17:58 2010 1 jnk 2 wnt 3 nm23 4 mdm2 5 akt 6 nm23-h1 7 vegf 8 k ras 9 mtor 10 stat3 11 erk1 12 mek1 13 beta catenin 14 cyclin e 15 her-2 neu 16 jak2 17 erbb-2 18 phosphatidylinositol 3-kinase 19 braf 20 egfr tyrosine 21 pi3k 22 her2 23 cdk4 24 egfr tyrosine kinase 25 pten 26 her-2 27 map kinase 28 metastasis suppressor 29 raf-1 30 e2f1 31 metastasis suppressor gene 32 mutation egfr 33 cdk2 34 caspase-8 35 p53 tumor suppressor 36 axin 37 pd l1 38 brca1 39 erbb-2 gene 40 c kit 41 cdk6 42 mek 43 microrna 44 signal regulated kinase 45 anti egfr 46 p27 47 p38 mapk 48 smad4 49 cyclin d1 50 flt-1 51 multiple endocrine neoplasia 52 cip1 53 p16ink4a 54 lkb1 55 cyclin dependent kinase 56 erbb-2 oncogene 57 smad 58 ki ras 59 flt3 60 ret 61 p16ink4 62 e cadherin 63 waf1 64 vegfr 65 erbb2 66 skp2 67 c myc 68 caspase-9 69 exon 70 her2 neu 71 mage 72 kras2 73 c jun nh2-terminal 74 caspase 75 chk2 76 egfr signaling 77 c met 78 bcl-2 79 ink4a 80 nf kappab 81 neu overexpressing 82 receptor tyrosine kinase 83 cd44 84 ha ras 85 tumor suppressor gene 86 protooncogene 87 reck 88 sp1 89 genome wide 90 aurora a 91 pik3ca 92 rassf1 93 c jun 94 caveolin-1 95 polo kinase 96 egr-1 97 stat5 98 hepatocyte growth factor 99 cadherin 100 neu oncogene 101 glycogen synthase kinase 102 telomerase rna 103 retinoic acid receptor 104 bcr abl 105 h ras 106 kdr 107 muc1 108 neurotrophin 109 egr1 110 e1a 111 pkb 112 transcription factor 113 casein kinase 114 serine threonine kinase 115 gankyrin 116 hsp90 117 receptor kinase 118 vimentin 119 flk-1 120 her-2 neu overexpressing 121 gene promoter 122 fak 123 src 124 cd117 125 jak stat 126 galectin-3 127 egfr 128 erk 129 b raf 130 crk 131 p21cip1 132 tyrosine kinase 133 tgf beta 134 ret proto oncogene 135 p glycoprotein 136 cyclin 137 erbb 138 fkhrl1 139 prb 140 akt pkb 141 e2f 142 p16 143 mkp-1 144 proto oncogene 145 nras 146 rhoa 147 pp60c src 148 connexin43 149 p38 150 ron 151 c jun n 152 growth factor gene 153 erbb-2 neu 154 bcr 155 ezrin 156 beta gene 157 c src 158 oncogene tumor 159 oncogene a 160 tumor suppressor 161 cellular oncogene 162 necl-5 163 npm 164 p21 165 nude 166 factor receptor egfr 167 oncogenic kras 168 jnk sapk 169 tbetar 170 n ras 171 c raf 172 myc 173 caldesmon 174 foxo3a 175 jak 176 e6 177 glycogen synthase 178 integrin alpha 179 egf 180 p120 181 autophagy 182 p53 183 gene nm23 184 interleukin 185 tyrosine kinase receptor 186 smad2 187 neu 188 oncogene 189 receptor gene 190 fus1 191 abl 192 p185 193 rnai 194 allele specific 195 intron 196 sonic hedgehog 197 hox 198 protein kinase b 199 map kinase kinase 200 tenascin c 201 ets 202 raf 203 syk 204 reading frame 205 jun 206 lats2 207 lck 208 n myc 209 suppressor gene 210 anaplastic lymphoma kinase 211 env 212 tumor suppressor pten 213 nf2 214 nf kappa b 215 tumor suppression 216 helicase 217 epidermal growth factor 218 p19arf 219 shp-2 220 retrovirus mediated gene 221 related gene 222 p21ras 223 hipk2 224 gnas 225 integrin 226 progesterone receptor 227 tsc2 228 expressing ret 229 ap-1 230 hgf 231 nf 232 nore1 233 e1a gene 234 proto 235 thrombopoietin 236 chaperone 237 gab1 238 kras 239 c fos 240 lysyl oxidase 241 interferon regulatory factor 242 protein tyrosine phosphatase 243 beta globin gene 244 high mobility group 245 gene transfer 246 histone acetyltransferase 247 bone morphogenetic protein 248 gene encode 249 il-6 250 promoter 251 trail 252 ki 253 tgf beta1 254 immediate early gene 255 gene human 256 tcf 257 proline rich 258 repressor 259 wilm tumor gene 260 transgene 261 alk 262 ros 263 allelic 264 wnt-1 265 yb-1 266 bim 267 rab5 268 erbb4 269 gastrin 270 tyrosine phosphatase 271 akt1 272 rb 273 gtpase 274 eif4e 275 ubiquitin 276 decoy 277 kit 278 estrogen receptor 279 expression tumor suppressor 280 beta tubulin 281 pim-1 282 poliovirus receptor 283 ha 284 il-10 285 rna helicase 286 isoform 287 insulin growth factor 288 rho kinase 289 ras 290 csf-1 291 tpa 292 pi 3-kinase 293 p300 294 b7-h1 295 fas 296 protein kinase 297 atm 298 fibroblast growth factor 299 rho family gtpase 300 atp binding 301 nucleoside diphosphate kinase 302 genomic 303 arf 304 sh3 305 igf1r 306 cd45 307 akt3 308 h-ras 309 zinc finger protein 310 copy 311 g2 312 stat-3 313 plasminogen activator gene 314 pdgfr 315 mage a4 316 prostate cancer 317 tumor suppressor lkb1 318 rela 319 response element 320 g1 321 factor gene 322 integrin alpha v 323 rac1 324 rack1 325 cdc25a 326 cdc2 327 foxo1 328 nucleophosmin 329 neu encoded 330 pdgf b 331 thyroglobulin 332 sphingosine kinase 333 retinoblastoma 334 tetraspanin 335 p65 336 protein kinase c 337 rna polymerase 338 gsk-3beta 339 pkcdelta 340 raf1 341 tumor gene 342 pkc 343 plasminogen 344 mutant allele 345 gm3 346 shp2 347 ornithine decarboxylase 348 protein tyrosine kinase 349 oncogene induced 350 dynamin 351 senescence 352 hedgehog 353 tyrosine kinase kit 354 wilm tumor 355 tcr 356 beta1 357 neu erbb2 358 domain
个人分类: 知识发现|3502 次阅读|0 个评论
更多...

Archiver|手机版|科学网 ( 京ICP备07017567号-12 )

GMT+8, 2024-6-2 20:17

Powered by ScienceNet.cn

Copyright © 2007- 中国科学报社

返回顶部