研究发现吸烟饮酒均可增加食道癌风险 日本研究人员日前报告说,同时拥有吸烟、饮酒和基因类型差异等风险因子的人的食道癌发病率,是没有任何一个风险因子的人的357倍。 研究人员说,吸烟和饮酒是增加食道癌患病风险的两个生活习惯因素。研究人员分析了约1000名食道癌患者和约2700名健康人的血液。分析结果显示,如果将完全没有风险因子的人的患病危险定为1的话,那么同时拥有吸烟、饮酒和基因类型差异等因子的,其食道癌患病风险就会飙升。 研究小组介绍说,如果某人的基因属于处理酒精能力较低的类型,那么就应该更加注意控制过度吸烟和饮酒。 http://news.sina.com.cn/h/2010-12-16/093821652351.shtml http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi A-query: smoke or drink wine C-query: esophageal cancer The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 106 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here . The results of this search are saved under id # 7815 and can be accessed from the start page after you leave this session. There are 674 terms on the current B-list ( 221 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin. To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms. job id # 7815 started Wed Dec 15 21:37:35 2010 Max_citations: 50000 Stoplist: /var/www/html/arrowsmith_uic/data/stopwords_pubmed Ngram_max: 3 7815 Search ARROWSMITH A A_query_raw: smoke or drink wine Wed Dec 15 21:40:00 2010 A query = smoke or drink wine started Wed Dec 15 21:40:00 2010 A query resulted in 32115 titles 7815 Search ARROWSMITH C C_query_raw: esophageal cancer Wed Dec 15 21:41:27 2010 C: esophageal cancer 38671 A: pubmed_query_A 32115 AC: ( smoke or drink wine ) AND ( esophageal cancer ) 106 C query = esophageal cancer started Wed Dec 15 21:41:27 2010 C query resulted in 38671 titles A AND C query resulted in 106 titles 7579 B-terms ready on Wed Dec 15 21:43:17 2010 Sem_filter: Genes Molecular Sequences, and Gene Protein Names 674 B-terms left after filter executed Wed Dec 15 21:49:54 2010 674 B-terms left after filter executed Wed Dec 15 21:49:59 2010 674 B-terms left after filter executed Wed Dec 15 21:50:02 2010 674 B-terms left after filter executed Wed Dec 15 21:50:08 2010 Sem_filter: Genes Molecular Sequences, and Gene Protein Names 674 B-terms left after filter executed Wed Dec 15 21:53:26 2010 Sem_filter: Genes Molecular Sequences, and Gene Protein Names 674 B-terms left after filter executed Wed Dec 15 21:56:39 2010 B-list on Wed Dec 15 21:57:52 2010 1 fhit 2 cox-2 3 promoter polymorphism 4 gstm1 5 gstt1 6 akt 7 vegf 8 mthfr 9 gstp1 10 single nucleotide polymorphism 11 stat3 12 beta catenin 13 wnt 14 ercc1 15 tp53 16 pi3k 17 pten 18 adiponectin 19 mdm2 20 jnk 21 cyp2a6 22 promoter hypermethylation 23 cyp1a1 24 xrcc1 25 fdg 26 signal regulated kinase 27 promoter methylation 28 brca2 29 gene promoter polymorphism 30 microrna 31 ghrelin 32 cyclin d1 33 erk1 34 egr-1 35 gene promoter 36 matrix metalloproteinase 37 brca1 38 hogg1 39 survivin 40 nat2 41 toll receptor 42 nadph oxidase 43 cyp2e1 44 metabolic syndrome 45 nat1 46 genome wide 47 mtor 48 body mass index 49 nf kappab 50 runx3 51 n acetyltransferase 52 promoter polymorphism risk 53 claudin 54 histone deacetylase 55 gstm3 56 xpd 57 ercc2 58 caspase-3 59 aldh2 60 mgmt 61 tcf 62 gene environment 63 xpc 64 statin 65 egfr 66 caspase 67 smad 68 cyclin 69 repair gene xrcc1 70 p16 71 bax 72 waf1 73 mmp-1 74 e2f1 75 copd 76 polymorphism promoter region 77 dna repair gene 78 leptin 79 leptin receptor 80 dickkopf-1 81 p21 82 ets 83 glutathione s transferase 84 serial analysis gene 85 muc1 86 th1 87 nkg2d 88 body mass 89 aryl hydrocarbon receptor 90 cadherin 91 p53 92 hedgehog 93 c jun 94 caga 95 mlh1 96 chemokine receptor 97 mmp-2 98 p300 99 jak2 100 ugt1a1 101 k ras 102 gst 103 cd14 104 nrf2 105 nat2 gene 106 erk 107 hif-1alpha 108 bcl 109 epidermal growth factor 110 p38 111 clock gene 112 related gene 113 chemokine 114 cytokine 115 tumor suppressor gene 116 p16 ink4a 117 tumor suppressor 118 epic 119 bcl-2 120 caspase-9 121 phosphatidylinositol 3-kinase 122 drd2 123 bcl xl 124 exon 125 pgp9 126 mannose binding lectin 127 nf 128 ogg1 129 pet 130 caveolin-1 131 epoxide hydrolase 132 ctgf 133 rhoa 134 dnmt3b 135 map kinase 136 pxr 137 muc5ac 138 toll 139 ap-1 140 allele associated increased 141 promoter 142 estrogen receptor alpha 143 cox2 144 autophagy 145 ptpn13 146 ppargamma 147 neurotrophin 148 cytochrome p450 149 aldehyde dehydrogenase 150 snp 151 promoter associated 152 metabolizing gene 153 c myc 154 cd8 155 foxp3 156 expression gene 157 desmoglein 158 peroxiredoxin 159 prb 160 pcna 161 cancer genome 162 transcription factor 163 cxcl8 164 genomic 165 p450 166 manganese superoxide dismutase 167 d1 168 fas ligand 169 oxide synthase gene 170 flap 171 car 172 myc 173 tea 174 th2 175 mmp 176 tnf alpha 177 ephb4 178 mnsod 179 retinoic acid receptor 180 gene methylation 181 p21cip1 182 adiponectin receptor 183 igf 184 mmp-9 185 node 186 tgf beta 187 superoxide dismutase 188 paraoxonase 189 cea 190 cancer gene 191 codon 192 ct 193 obesity 194 cancer related gene 195 il10 196 il-6 197 protein kinase c 198 adiposity 199 xpa 200 dj-1 201 rarbeta 202 dna methyltransferase 203 bcl2 204 clusterin 205 t1 206 atm 207 nbs1 208 estrogen receptor 209 interferon regulatory factor 210 mate 211 cd44 212 abcb1 213 oncogene 214 methylation gene 215 m1 216 gt 217 tnf 218 p1 219 gene cluster 220 beta1 221 ros http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/show_sentences.cgi Start A-Literature C-Literature B-list Filter Literature AB literature B-term BC literature smoke or drink wine fhit esophageal cancer 1: Prognostic value of FHIT , CTNNB1, and MUC1 expression in non-small cell lung cancer.2008 Add to clipboard 2: Molecular and cytogenetical alterations induced by environmental cigarette smoke in mice heterozygous for Fhit .2007 Add to clipboard 3: Early loss of Fhit in the respiratory tract of rodents exposed to environmental cigarette smoke.2006 Add to clipboard 1: Nit1 and Fhit tumor suppressor activities are additive.2009 Add to clipboard 2: 2009 Add to clipboard 3: FHIT oncosuppressor gene expression profile in human anal cancers.2007 Add to clipboard 4: A Fhit -ing role in the DNA damage checkpoint response.2007 Add to clipboard 5: Expression of FHIT in esophageal epithelium and carcinoma: reference to drinking, smoking and multicentric carcinogenesis.2006 Add to clipboard 6: Fhit modulates the DNA damage checkpoint response.2006 Add to clipboard 7: Promoter hypermethylation of p16INK4a, E-cadherin, O6-MGMT, DAPK and FHIT in adenocarcinomas of the esophagus, esophagogastric junction and proximal stomach.2005 Add to clipboard