结构论来源于许多学科领域的思想总结,但核心观点依然是建筑学概念,系统生物工程的目的就是实现生物机器的工程化设计和装配,以及仿生学与遗传学的整合;因此,系统遗传学原理是基础。 Systems Genetics Resource http://systems.genetics.ucla.edu/ NBIC Genotype-phenotype modelling http://www.nbic.nl/research/research-projects/genotype-phenotype-modelling/ SysGenSIM – Homepage http://sysgensim.sourceforge.net/ Channing Division of Network Medicine - Systems Genetics and Genomics http://brighamandwomens.org/research/depts/medicine/channing/systems-genetics/default.aspx?sub=0 D5c3 - Dream Initiative http://wiki.c2b2.columbia.edu/dream/index.php/D5c3 Genetica, Volume 138, Numbers 9-10 – SpringerLink http://www.springerlink.com/content/k078gkq910232141/ Systems Genetics for Experimental Crosses http://pages.stat.wisc.edu/~yandell/statgen/sisg/ Systems Genetics HMS Department of Genetics http://genetics.med.harvard.edu/taxonomy/term/46 Carolina Center for Genome Sciences http://genomics.unc.edu/projects/sgccc.html Symposium of Systems Genetics* http://www.nbic.nl/research/nbic-researchers/press/detail/article/successful-1st-symposium-on-systems-genetics/ http://www.systemsgenetics.nl/ Systems genetics from statistical genetics to mechanistic models in systems biology** http://www.embl.de/~gagneur/sysgen11/ UNC Systems Genetics Core Facility http://atlas.uthsc.edu/pipermail/ctc/2012-July/000038.html talks.cam Modelling in systems genetics computational approaches for discovering disease networks http://talks.cam.ac.uk/talk/index/34759 Integrated systems-genetics approaches deciphering the biological function of genes and gene networks that drive disease EBI http://www.ebi.ac.uk/Information/events/calendar/viewevent.php?events_subcategory_id=start_date=20101014000000events_data_id=1979 等等,系统遗传学在国际上发展趋势的资讯已经非常多了。 : * ,第 2 届说明了是“ National ” ( http://www.nvvm-online.nl/modules/extcal/event.php?event=264 ); ** , 我参与了 2010 和 2011 年2届 ICSB 会议。
以下文字论述的观点非常准确地就是90年代未在海外我以系统遗传学(94年在国内发表提出和96年*国际转基因动物研讨会阐述)观点与孟德尔遗传学观点争论焦点的生动写照 - 就如同该文作者当时就在旁边观看(实际不可能)我的争辩(99年建立英文网和03年国际遗传学大会再次论述)一般。 另外,直到11月冷泉港亚洲年会,至今为止,世纪之交合成生物学的开创者们都已经非常明确地论说在系统论层面上的计算生物学、实验生物学结合的生物系统工程(engineering of biosystem)和人工生物系统的研究 - 即系统生物工程概念或范式。 *,从这里留学海外继续大规模国际通信与论述,而今为的是另一个梦想 - 生物工业革命,从英国工业革命发源地来到江南,曾经是明清中国工商业萌芽的地方,能否在21世纪第三次工业革命成为未来的新兴产业崛起区域呢? ------------------------------------------------------ Systems Genetics Joseph H. Nadeau and Aimée M. Dud From studies with peas over 150 years ago, Gregor Mendel deduced the laws that govern the inheritance of traits in most organisms. The brilliance, but also the limitation, of Mendel's work was its focus on single-gene traits, such as flower color and plant height. However, phenotypic variation, including that which underlies health and disease in humans, often results from multiple interactions among numerous genetic and environmental factors. Systems genetics seeks to understand this complexity by integrating the questions and methods of systems biology with those of genetics to solve the fundamental problem of interrelating genotype and phenotype in complex traits and disease. http://www.sciencemag.org/content/331/6020/1015.summary?sa_campaign=Email%2Ftoc%2F25-February-2011%2F10.1126%2Fscience.1203869
CIGENE – Home - http://www.cigene.no/ CSI - Cell Systems Biology - http://www.cellsystems.org/teams/cellbiology/index.html Evolutionary Approach to Synthetic Biology - http://www.nis.atr.jp/~ray/pubs/zen/ Evolutionary Genetics - http://www.eva.mpg.de/genetics/files/team_paabo.html GeneSys Project Homepage - http://www.genesys.ac.uk/ Genetics Faculty-Joseph Nadeau - http://genetics.case.edu/?page_id=5LN=NadeauFN=Joseph Genomic Science Program, U.S. Department of Energy - http://genomicscience.energy.gov/ http--www.geneart.com- - http://www.geneart.com/ NYU Biology Center for Genomics and Systems Biology - http://biology.as.nyu.edu/object/facilities.gsb.html Stanford Center for Biomedical Informatics Research, Genetics of Cancer Grant - http://bmir.stanford.edu/pages/view.php/genetics_of_cancer_grant Synthetic Genomics - http://www.syntheticgenomics.com/ Synthetic Genomics Home - http://www.syntheticgenomics.com/ Sys Genetics - http://service004.hpc.ncsu.edu/mackay/Good_Mackay_site/Sys_Genetics.html Systems Genetics - http://www.wingx.ch/research/subgroups/systems_genetics/ Systems genetics – Home - http://www.systemsgenetics.dk/ Systems Genetics Analyst Salaries in Blacksburg, VA Simply Hired - http://www.simplyhired.com/a/salary/search/q-Systems+Genetics+Analyst/l-Blacksburg,+VA The evolution of genetic systems Home - http://www.cob.lu.se/gensyst/ The genetics and evolution of complex traits - http://www.biology.duke.edu/nijhout/complextraits.htm UNC Computational Genetics - http://compgen.unc.edu/wp/ UNC Computational Genetics CISGen Systems Genetics of Psychiatric Disorders - http://compgen.unc.edu/wp/?page_id=135 (注:依据结构论的3规律,系统与整合生物学、合成与建构生物学为等价概念。)