以下论文尤其是图片非常好和直观地描述了什么将是未来的细胞工厂和生物工业 - 一种新的工业生产与自动控制模式。系统生物工程(1994年)在系统科学理论和现代生物技术、计算机技术等 - 遗传工程和仿生工程在分子细胞生物系统层面整合新的工程学范式 - 涉及生物(转基因和生物炼制)反应器、生物计算机和太阳能生物技术(生物能源和代谢工程)等。1999年筹备国际系统生物科学与工程会议,我用“genomic intelligence”、“artificial biosystem”和细胞内信号传导、基因调控网络的微电子元件和转基因技术的分子、细胞、神经元到神经网络的示意图,2002年在线发布细胞内分子系统模块和细胞通讯设计的遗传学与仿生学整合的“automatic cell - the bio-computer”原理图。 另,据说蒸汽机是水车与鼓风机结合的原理,这让我想起中国明清的纺织业和工商业萌芽,于是来到了江南 。 --------------------------- Curr Opin Biotechnol. 2010 Aug;21(4):572-81. Epub 2010 Aug 9. Programming cells: towards an automated 'Genetic Compiler'. Clancy K , Voigt CA . Life Technologies, 5791 Van Allen Way, Carlsbad, CA 90028, USA. Abstract One of the visions of synthetic biology is to be able to program cells using a language that is similar to that used to program computers or robotics. For large genetic programs, keeping track of the DNA on the level of nucleotides becomes tedious and error prone, requiring a new generation of computer-aided design (CAD) software. To push the size of projects, it is important to abstract the designer from the process of part selection and optimization. The vision is to specify genetic programs in a higher-level language, which a genetic compiler could automatically convert into a DNA sequence. Steps towards this goal include: defining the semantics of the higher-level language, algorithms to select and assemble parts, and biophysical methods to link DNA sequence to function. These will be coupled to graphic design interfaces and simulation packages to aid in the prediction of program dynamics, optimize genes, and scan projects for errors. http://www.ncbi.nlm.nih.gov/pubmed/20702081
Colorado Initiative in Molecular Biotechnology, CU Boulder Building - http://bayes.colorado.edu/biotech/building.html EPFL LCSB - http://lcsb.epfl.ch/ ETH - IMSB Institute for Molecular Systems Biology - Center of Biosystems Engineering (C-BSSE) - http://www.imsb.ethz.ch/ Forschungszentrum Jülich - Systems Biotechnology - http://www.fz-juelich.de/ibg/ibg-1/EN/Research/SystemsBiotechnology/_node.html Gallery of Molecular Machines - http://www.wag.caltech.edu/gallery/gallery_nanotec.html Genomics and Systems Biotechnology Laboratory Home - http://gsbl.ucsd.edu/ Life sciences bioengineering, systems and synthetic biology - The IET - http://kn.theiet.org/lifesciences/ Molecular Systems Bioengineering - http://www.rci.rutgers.edu/~cmroth/ Molecular Systems Bioengineering Research Group - http://unit.aist.go.jp/bpri/bpri-msbi/index_e.html Nanorex, Inc. - Molecular Machinery Gallery - http://nanoengineer-1.com/content/index.php?option=com_contenttask=viewid=40Itemid=50 Peptide and Protein Building Blocks for Synthetic Biology – EHC Broomley et al. Freelancing science - http://freelancingscience.com/2008/02/04/peptide-and-protein-building-blocks-for-synthetic-biology-ehc-bromley-et-al/ RobAid Robots, gadgets, tech, bionics and green architecture news - http://www.robaid.com/ Ron Weiss - ACM author profile page - http://portal.acm.org/author_page.cfm?id=81332534610coll=GUIDEdl=GUIDEtrk=0CFID=95207127CFTOKEN=89027479 Ron Weiss' Personal Page - http://groups.csail.mit.edu/mac/users/rweiss/ Scientists Glimpse Cellular Machines At Work Inside Living Cells - http://www.sciencedaily.com/releases/2002/11/021122074846.htm systems bioengineering - http://vivo.cornell.edu/display/individual26373 Systems Bioengineering - Biomatics.org - http://biomatics.org/index.php/Systems_Bioengineering Systems Biotechnology - http://www.csm.bio.dtu.dk/Research/Systems%20biotechnology.aspx TUM BioVT Systems Biotechnology - http://www.biovt.mw.tum.de/en/systembiotechnologie/ (注:系统生物工程 -SBE 整合了 systems “ biotechnology, bioengineering, biomedical engineering, biosystem engineering ”的概念)
Dear Colleagues, The biosystem science and engineering* --- biosystem patterns, bio-logic of genome and biotechnology of molecular, cellular organ biosystems. Today, we are all experiencing an era of much faster development in world wide molecular biology, computer science genetic engineering. ----- The purpose for the CABSE is ---- on the molecular science and engineering of signaling genetic control of biosystem patterning, the signal transduction regulation of gene expression in cellular, neural network organ morphogenesis, and gene cloning, transgenics, nanotechnology, biomolecular computing . --- investigating the interdisciplinary of various fields. ---- diversified aspects of molecular and cellullar biology of development and evolution of biosystem modules . ---- will cover a wide range of topics on the signal transduction of gene expression, RNA transcription; protein translation, localization and degradation; cell division, DNA replication, mutagenesis, amplication and fragmentation; molecular cloning, recombination, transgenesis, DNA based computation, protein engineering etc. for the best understanding of multiple signals controlling of genomic program in biosystem patterns ---. The CABSE is intended to embrace both --- for computational and experimental biologists ---- We are looking forward to welcome you to attend the CABSE for an exciting scientific and cultural experience. Cordially yours ------------- The (World) Associates for Biosystem Science and Engineering (WABSE), ---for the advancement of investigating the bio-logic foundamentals and bio-industrial applications of the genomic intelligence, artificial biosystems . The biosystem science and engineering is the computational, experimental and engineering manipulation of biosystems , includes the genetic (biopharmacy, transgenesis - the (International) Union of TransGenics (IUTG)) and bionic (nano-robotics, biochip computing) analysis of biosystems in genomes and organisms . The WABSE will promote the research of the biosystem patterning from biomolecules, cellular phenotypes to organic systems such as neural network, vascular systems, and the development of bionic intelligence, transgenic organism etc. for the bio-industrialization. ---- for global cooperation in transgenics and functional genomics, ------, which includes the divisions of nanotechnology, biocomputing and transgenics etc., ------ in response to hold conference exhibition on biosystem science engineering, and publish the Structurity Bulletin (biosystem analytics) ----. -- 1999年-2001 年的会议邀请函及协会介绍(涉及系统 \ 计算机 \ 纳米 \ 生物 \ 医药 \ 工程等广泛领域的通讯,以生物系统技术为主),另有细胞内电子元件与转基因的设计示意图(见博文 -“相对论与结构论”)等 -- 注*: 1968 、 1993 年国际上已有“ systems biology” ( 1989 年为生化代谢与计算生物学), 1910 、 1974 、 1980 年国际上已有 “synthetic biology” ( 1974 年为 DNA 分子重组与合成); 1992 、 1994 年曾杰(邦哲)提出“ system genetics, systems medicine, system bio-engineering”(以生物系统理论为主)- 总称“ systems biological-science” ( 1996 -1999 年转换为 “biosystem science engineering” - wabse/bsse.html及系统理论与生物技术的整合概念, 2007年瑞士ETH建立BSSE - http://www.bsse.ethz.ch/ 系)。 系统生物学 - 理论生物学部分:1)系统科学理论(systems theory)、2)系统数学模型(systems modelling)等。 - 生物技术部分: 1)组学(omics)生物学(功能基因组、高通量实验等)、2)计算生物学(生物信息、e-cell软件模型等)、3)合成生物学(DNA、基因组合成、基因工程等)、4)纳米生物学(生物分子计算、芯片制作等)。 另外: 1996年国际转基因动物学术研讨会 - 我多用“biosystem theory”和“system bio-engineering”。 在 20 世纪最初 “s ystems biology ”和“ biosystem science ” 都是用于生态系统的概念, 21 世纪都转换到分子生物系统研究 。