Identfication of key miRNAs in pancreatitis using bioinformatics analysis of microarray data https://apps.webofknowledge.com/full_record.do?product=WOSsearch_mode=GeneralSearchqid=1SID=1F5FzXxuQTfHLSJ4E7Spage=1doc=2 作者: Wang, DD (Wang, Dadong) ; Zhu, ZM (Zhu, Zi-Man) ; Tu, YL (Tu, Yu-Liang) ; Dou, CQ (Dou, Chun-Qing) ; Xu, Y (Xu, Yong) ; Tan, XL (Tan, Xiang-Long) ; Han, MM (Han, Ming-Ming) ; Yang, ZJ (Yang, Zhuang-Jie) ; Jin, X (Jin, Xin) ; Zhang, B (Zhang, Bao) ; Cai, SW (Cai, Shouwang) ; Liu, ZW (Liu, Zhi-Wei) 更多内容 更少内容 MOLECULAR MEDICINE REPORTS 卷: 14 期: 6 页: 5451-5460 子辑: B DOI: 10.3892/mmr.2016.5928 出版年: DEC 2016 查看期刊信息 MOLECULAR MEDICINE REPORTS 影响因子 1.559 1.617 2015 5 年 JCR ® 类别 类别中的排序 JCR 分区 MEDICINE, RESEARCH EXPERIMENTAL 85/124 Q3 ONCOLOGY 177/213 Q4 数据来自第 2015 版 Journal Citation Reports ® 出版商 SPANDIDOS PUBL LTD, POB 18179, ATHENS, 116 10, GREECE ISSN: 1791-2997 eISSN: 1791-3004 研究领域 Oncology Research Experimental Medicine 摘要 Pancreatitis is a type of inflammation in the pancreas, which frequently occurs due to alcohol and gallstones. The present study aimed to identify pancreatitis-associated microRNAs (miRNAs) by analyzing the microarray of GSE24279. GSE24279 was downloaded from the Gene Expression Omnibus, composed of a collective of 27 pancreatitis and 22 normal control samples. The differentially expressed miRNAs (DE-miRNAs) in pancreatitis samples were screened using the Limma package in Bioconductor. Subsequently, target genes of the DE-miRNAs were predicted using the miRecords and miRWalk databases. Their potential functions were analyzed by functional and pathway enrichment analysis using the Database for Annotation, Visualization and Integrated Discovery online tool. Finally, pancreatitis-associated genes among the target genes identified were searched using the Comparative Toxicogenomics Database, and a regulatory network of pancreatitis-associated genes and their target miRNAs were constructed using Cytoscape software. A total 14 upregulated and 39 downregulated miRNAs were identified in pancreatitis samples compared with control samples and 290 target genes of DE-miRNAs were determined. Cyclin D1 (CCND1), v-akt murine thymoma viral oncogene homolog 2 (AKT2), cyclin-dependent kinase 6 (CDK6) and SMAD family member 2 (SMAD2) were involved in the pathway of pancreatic cancer. Among the target genes, 279 genes were pancreatitis-associated genes, which in turn were targeted by 37 miRNAs in the regulatory network. Hsa- miR-15a , hsa-miR- 16 , hsa-miR-155, hsa-miR-375 and hsa-miR-429 in particular may be involved in pancreatitis by targeting genes in the regulatory network, including hsa- miR-15a - CCND1, hsa-miR- 16 - CCND1, hsa-miR-155 - CCND1/SMAD2, hsa-miR-375 - AKT2/CDK6 and hsa-miR-429 - CCND1. The above miRNAs and their targets may contribute to the pathogenesis of pancreatitis; therefore, they may be potential therapeutic targets. 关键词 作者关键词: pancreatitis ; differentially expressed miRNAs ; target genes ; enrichment analysis ; regulatory network KeyWords Plus: DUCTAL ADENOCARCINOMAS ; CYCLIN D1 ; CANCER ; EXPRESSION ; OVEREXPRESSION ; GENE ; SURVIVAL ; ALCOHOL ; PATHWAY ; TUMORS 作者信息 通讯作者地址: Cai, SW; Liu, ZW (通讯作者) Chinese Peoples Liberat Army Gen Hosp, Dept Hepatobiliary Surg, 28 Fuxing Rd, Beijing 100853, Peoples R China. 增强组织信息的名称 Chinese People's Liberation Army General Hospital 地址: Chinese Peoples Liberat Army Gen Hosp, Affiliated Hosp 1, Dept Hepatobiliary Surg, Beijing 100048, Peoples R China 增强组织信息的名称 Chinese People's Liberation Army General Hospital Chinese Peoples Liberat Army Gen Hosp, Dept Surg Oncol 2, Beijing 100853, Peoples R China 增强组织信息的名称 Chinese People's Liberation Army General Hospital Chinese Peoples Liberat Army Gen Hosp, Dept Hepatobiliary Surg, Beijing 100853, Peoples R China 增强组织信息的名称 Chinese People's Liberation Army General Hospital 电子邮件地址: caisw8077.cai@vip.sina.com ; zhiweiliuzzz@hotmail.com 出版商 SPANDIDOS PUBL LTD, POB 18179, ATHENS, 116 10, GREECE 类别 / 分类 研究方向: Oncology; Research Experimental Medicine Web of Science 类别: Oncology; Medicine, Research Experimental 文献信息 文献类型: Article 语种: English 入藏号: WOS:000391076200003 PubMed ID: 27840954 ISSN: 1791-2997 eISSN: 1791-3004 期刊信息 Impact Factor (影响因子): Journal Citation Reports ® 数据来自第 2015 版 Journal Citation Reports ® 其他信息 IDS 号: EG5HZ Web of Science 核心合集中的 引用的参考文献: 43 Web of Science 核心合集中的 被引频次: 0
原文地址： http://glmigratorybirds.org/resources.html A selection of key stopover papers These papers were selected from among the Huge Stopover Bibliography to include studies of each of the bird groups (landbirds, shorebirds, and waterfowl) that (1) may be generally applicable throughout the Great Lakes region, and (2) that have been done in different parts of the Great Lakes basin. Many other papers cited in the bibliography complement the papers noted below, including detailed site-specific information that will be useful for implementing on the ground conservation strategies. Hover over the title to get a brief description of the article. Bonter, D.N., S.A. Gauthreaux, Jr., and T.M. Donovan. 2009. Characteristics of important stopover locations for migrating birds: Remote sensing with radar in the Great Lakes basin. Conservation Biology 23:440-448. Buler, J.J. and D.K. Dawson. 2014. Radar analysis of fall migration stopover sites in the northeastern U.S. The Condor Ornithological Applications 116:357-370. Diehl, R.H., R.P. Larkin, and J.E. Black. 2003. Radar observations of bird migration over the Great Lakes. The Auk 120:278-290. Dunn, E.H. 2000. Temporal and spatial patterns of mass gain of Magnolia Warblers during migration. The Auk 117:12-21. Ewert, D.N., G.J. Soulliere, R.D. Macleod, M.C. Shieldcastle, P.G. Rodewald, E. Fujimura, J. Shieldcastle, and R.J. Gates. 2006. Migratory bird stopover site attributes in the western Lake Erie basin. Final report, George Gund Foundation. Ewert, D.N., M.J. Hamas, R.J. Smith, M.E. Dallman, and S.W. Jorgensen. 2011. Distribution of migratory landbirds along the northern Lake Huron shoreline. Wilson Journal of Ornithology 123:536-547. Faaborg, J., R.T. Holmes, A.D. Anders, K.L. Bildstein, K.M. Dugger, S.A. Gauthreaux, Jr., P. Heglund, K.A. Hobson, A. E. Jahn, D.H. Johnson, S.C. Latta, D.J. Levey, P.P. Marra, C.L. Merkford, E. Nol, S.I. Rothstein, T.W. Sherry, T.S. Sillett, F.R. Thompson III, and N. Warnock. 2010. Conserving migratory land birds in the New World: Do we know enough? Ecological Applications 20:398-418. France, K.E., M. Burger, M.D. Schlesinger, K.A. Perkins, M. MacNeil, D. Klein and D.N. Ewert. 2012. Final report for Lake Ontario Migratory Bird Stopover Project. Prepared by The Nature Conservancy for the New York State Department of Environmental Conservation (Grant C303907 from the New York Great Lakes Protection Fund). Available from www.nature.org/nybirds . Lott, K.D., M. Seymour, and B. Russell. 2011. Mapping pelagic bird distribution and abundance as a decision-making tool for offshore wind turbine development and conservation planning. Available from: hyperlink Petit, D.R. 2000. Habitat use by landbirds during Nearctic-Neotropical migration routes: implications for conservation of stopover habitats. Studies in Avian Biology 20: 15-33. Potter, B.A., R.J. Gates, G.J. Soulliere, R.P. Russell, D.A. Granfors, and D.N. Ewert. 2007. Upper Mississippi River and Great Lakes Joint Venture Shorebird Habitat Conservation Strategy. U.S. Fish and Wildlife Service, Fort Snelling, MN. 101 pp. Soulliere, G.J., B.A. Potter, J.M. Coluccy, R.C. Gatti, C.L. Roy, D.R. Luukkonen, P.W. Brown, and M.W. Eicholz. 2007. Upper Mississippi River and Great Lakes Region Joint Venture Waterfowl Habitat Conservation Strategy. U.S. Fish and Wildlife Service, Fort Snelling, Minnesota, USA.
http://li.mit.edu/Archive/Graphics/A/#making_movie What is the Meta key? Some environments forbid the use of Meta or Alt key. In those cases, having CapsLock at "on" works as if the Meta key is pressed
http://soft.proindependent.com The Graph Menu This menu is only active (visible) when a graph window is selected. Graph - Add/Remove Curves... ( Alt-C ) Opens the Add/Remove Curves... dialog , allowing easy addition or removal of curves from the active plot layer. This dialog can also be used to modify a curve which is already plotted by changing the columns which are used as X or Y values. The curve is added to the currently active layer. If there is no layer on the graph, an error message will pop-up. Graph - Add Function... ( Ctrl-Alt-F ) Opens the Add Function... dialog . This command is used to add new function curves to an existing layer. New curves are added to the currently active layer. Graph - Add Error Bars... ( Ctrl-B ) Opens the Add Error Bars... dialog . You can add error bars to X and/or Y values on an existing plot. Error bars are added to the currently active layer. Graph - New Legend ( Ctrl-L ) Adds a new legend object to the active layer. You can have more than one legend on a plot. These legends can later be customized by double clicking on a given legend. Graph - Add Equation ( Alt-Q ) This command is used to add a Tex formatted equation on a layer. When selected, the cursor changes to an edit text cursor. You must then click in the plot area to specify the position of the new Tex equation. A Tex equation editor will pop-up allowing you to enter the equation to be displayed and set all its properties (color, font, etc...) Graph - Add Text ( Alt-T ) This command is used to add text items on a layer. When selected, the cursor changes to an edit text cursor. You must then click in the plot area to specify the position of the new text box. A text dialog will pop-up allowing you to type the text to be displayed and set all its properties (color, font, etc...) Graph - Draw Arrow ( Ctrl-Alt-A ) Changes the active layer's operational mode to drawing mode. You must click on the layer canvas in order to specify the starting point for the new arrow, and then click once more to specify its ending point. You can edit the new arrow using the Arrow dialog. Switch back to the normal operating mode by clicking the "Pointer" icon in the Plot toolbar. Graph - Draw Line ( Ctrl-Alt-L ) Changes the active layer's operational mode to drawing mode. You must click on the layer canvas in order to specify the starting point for the new line, and then click once more to specify its ending point. You can edit the new line using the line dialog. Switch back to normal operating mode by clicking the "Pointer" icon in the Plot toolbar. Graph - Add Rectangle ( Ctrl-Alt-R ) Draws a rectangular box on the active plot layer. After selecting this command, the pointer changes to a crosshair target. Click and hold the left mouse button on the active layer to indicate the first corner of the rectangle, then drag the cursor to the opposite corner of the rectangle. Once the second point is specified, release the left mouse button to draw the rectangle. The pointer automatically changes back to normal mode. Graph - Add Ellipse ( Ctrl-Alt-E ) Draws a elliptical shape on the active plot layer. After selecting this command, the pointer changes to a crosshair target. Click and hold the left mouse button on the active layer to indicate the first corner of the ellipse's bounding rectangle, then drag the cursor to the opposite corner of the bounding rectangle. Once the second point is specified, release the left mouse button to draw the ellipse. The pointer automatically changes back to normal mode. Circles may be drawn using this command by setting the height and width equal. (The object properties dialog can be used to set height and width to exactly the same value.) Graph - Add Time Stamp ( Ctrl-Alt-T ) This command is used to add a special label in the active layer which contains the current date and time. The properties of this label can be customized like any other label added by the Add Text . The date and time copied into a timestamp label is not modified later if the plot is modified, saved, etc. Graph - Add Image ( Alt-I ) Opens a file dialog allowing you to select an image to be added to the active plot layer. Only a link to the image file will be saved into the project file and not the image itself. The new image is added to the left-top corner of the layer and can be moved with the mouse using drag-and-drop. Z-Order Commands... The zorder commands act upon the last few items. Even though they do not appear in the graph menu, they are in the plot toolbar and in the object drop down lists when right clicking a selected object. Move to Top Although this command does not appear in the Graph menu, it does act upon the objects created using the last few commands (specifically legend, equation, text, timestamp, ellipse, rectangle and image objects). When a suitable object is selected, this command will be available, either from the Plot toolbar or from the drop-down list that appears when right-clicking on a selected object. When the command is used, the object will be made visible by being promoted to the front of the plot layer. It does not affect the z-order relative to other objects. Their relative z-order depends only upon their order of creation. Move to Bottom Although this command does not appear in the Graph menu, it does act upon the objects created using the last few commands (specifically legend, equation, text, timestamp, ellipse, rectangle and image objects). When a suitable object is selected, this command will be available, either from the Plot toolbar or from the drop-down list that appears when right-clicking on a selected object. When the command is used, the object will be made invisible by being demoted to the back of the plot layer. It does not affect the z-order relative to other objects. Their relative z-order depends only upon their order of creation. Graph - Add Layer ( Alt-L ) Adds a new layer to a graph window. The command opens a dialog which allows you to select whether the new layer is to be added to the left-top corner of the plot window or to a best-guess position (based on a layer positioning algorithm in columns and rows). Graph - Add Empty Inset Layer This is a convenience command that creates a new, small sized, empty layer located on top of the currently selected layer. Once this layer is created, you can further resize, move, set it's properties and add curves to it as needed. Inset layers are not linked to another layer in any way. They just happen to be located in the same place on the graph window. In fact the inset layer can be moved anywhere on the graph window and is treated like a normal layer in every way. When the inset layer is completely contained inside another layer, it will disappear under that layer when it is selected. The new inset layer has it's own layer select button in the upper left of the graph window. Clicking on this button will bring the inset back to the front, rendering it visible again. Graph - Add Inset Layer With Curves This command is essentially identical to the Add Empty Inset Layer command, with the single exception that any curves contained in the currently active layer are duplicated in the new inset layer. Graph - Arrange Layers ( Shift-A ) Opens the Arrange layers dialog . This dialog allows you to customize the layout of the layers in the active graph window. Graph - Automatic Layout command Automatically arranges all the layers in the active graph window. There must be at least 2 layers on the graph. Layers are packed into the smallest dimensioned array possible. All layers are scaled to fit into the existing graph window. Rows are added until a the smallest square array is filled, at which point an additional column is added. Rows are then filled and additional rows added until the array is again square. For example, 2 layers results in a 1x2 array. 3 layers produces a 2x2 array with an empty space in the second row. 4 layers produces a full 2x2 array. Adding another layer will produce a 2x3 array, with one empty space in the second row. Additional layers result in more rows and columns being added to contain all the layers. Graph - Extract to Graphs command Each layer in the currently active graph window is copied into its own, newly created, graph window. The scale and size of the new layer is the same as the original layer. The original graph window remains unchanged. Graph - Extract to Layers command Each curve in the currently active layer is moved onto a newly created layer. The original layer is destroyed. The newly created layers are then auto arranged (see the Automatic Layout command). Graph - Remove Layer ( Alt-R ) Deletes the active layer and pops-up a question dialog allowing you to choose whether the remaining layers should be automatically re-arranged or not.
在佛罗里达的南端，与古巴隔海相望的水域上，撒落着一串珍珠般的岛屿，大约有上百个之多。这些岛屿的地质成因和冰川纪有关，我是外行，去了几个网站看了还是一头雾水不得要领。以后苏老师或其他诸位地质大拿要是有兴趣开课，我一定搬个小板凳认真听讲。 珍珠与项链 一条一号公路，把这些岛屿串成了珍珠项链。沿着这条公路一直往西开，阅过无数海天相连的美景后，来到这条公路的尽头，那就是有着天涯海角之称的 Key West 了。 路上的风景 Key West 有一条贯穿全城、一直延伸到海上的商业街—— Duval Street ，没去之前读介绍，我以为那大概就是 Key West 的王府井了，到了之后才发现，根本不是那么回事儿。满大街的酒吧，夹杂着画廊和卖文化衫、雪茄及其他旅游纪念品的商店，说它像什刹海的烟袋斜街似乎更合适。那些文化衫，有一些愤世嫉俗，又有一些玩世不恭，像是愤青与嬉皮士的混合体，道出了部分聚集在天涯海角的人们冷眼看洋却又有那么一份不甘寂寞的独特心态。除了嬉皮文化，海盗文化也在 Key West 留下了一笔，连街上的圣诞老人都是歪带着一只眼罩的，可惜我当时骑着车还担着殿后保安的责任，没能拍下这在美国本土看不见的一景儿。 海上的酒吧 文化衫 老宅 酒肆的招牌 来自古巴的雪茄 这个我也是头回见，像是到了雨果的小说里——会看手相的吉普赛人 如果说 Duval Street 是 Key West 的烟袋斜街，那 Duval Street 尽头的 Mallory 广场就是地坛了。那里也是 Key West 最著名的观日落的景点，每天日落时分，广场上热闹无比，各色人等纷纷出笼，有小商小贩，愤青盲流，耍把式的艺人，能量巨大的传教者，怀抱吉他的颓废青年，专拣老歌唱的音乐人，林林总总，不一而足。这些人在广场上各占一隅，使出浑身解数招揽游客，构成了 Key West 观日落的另一道风景，和海上的归帆、暮色中飞翔的海鸟相映成趣。 玩火的 背朝大海走单索的 女艺人 有许多名人曾经在 Key West 流连并在这个天涯海角的小镇上留下了永久的痕迹，海明威就是其中之一。海明威的故居是 Key West 的一个著名景点，里面参天蔽日的热带作物让我很想进去走一走，奈何时间有限，只能在骑车路过时一望了之。好在 Key West 到处都是盛开的鲜花和高高的棕榈树，遗憾并不算太大，反正我已经很久不读海明威了。
My application for this blog has been approved! I am glad to get this news. I know this place has supplied a free space for some kinds of scientists expressing and sharingtheir ideas and thoughts much more referred to their research fields-chemistry, atmosphere, mathematics, physics....but for me, probably it will be a place for more free topics-I just mean I would like to say something about my life, my hobbies, my friends, of course and my career. I have a blog in msn space, however because of some reasons people including me can not allowed to use it any more next year, so I move it to here, I hope today is a good start for my first record here. I am thinking about something now, I know it is always a learning process-wherever and whenever you need to learn new things for new career in one's life.
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