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Obestatin,ghrelin和peptide yy与食物摄取的关系知识发现
xupeiyang 2010-12-27 09:04
http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi Start A-Literature C-Literature B-list Filter Literature A-query: food intake C-query: Obestatin and ghrelin and peptide yy The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 160 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here . The results of this search are saved under id # 23889 and can be accessed from the start page after you leave this session. There are 93 terms on the current B-list ( 22 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin. To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms. job id # 23889 started Sun Dec 26 20:41:06 2010 Max_citations: 50000 Stoplist: /var/www/html/arrowsmith_uic/data/stopwords_pubmed Ngram_max: 3 23889 Search ARROWSMITH A A_query_raw: food intakeSun Dec 26 20:41:26 2010 A query = food intake started Sun Dec 26 20:41:27 2010 A query resulted in 50000 titles 23889 Search ARROWSMITH C C_query_raw: Obestatin and ghrelin and peptide yy Sun Dec 26 20:41:49 2010 C: Obestatin and ghrelin and peptide yy 315 A: pubmed_query_A 128188 AC: ( food intake ) AND ( Obestatin and ghrelin and peptide yy ) 160 C query = Obestatin and ghrelin and peptide yy started Sun Dec 26 20:41:49 2010 C query resulted in 315 titles A AND C query resulted in 160 titles 1363 B-terms ready on Sun Dec 26 20:44:45 2010 Sem_filter: Genes Molecular Sequences, and Gene Protein Names 93 B-terms left after filter executed Sun Dec 26 20:47:52 2010 B-list on Sun Dec 26 20:48:44 2010 1 adiponectin 2 glp-1 3 ghrelin 4 peptide yy 5 leptin 6 gip 7 glp-2 8 islet amyloid polypeptide 9 pyy 10 yy 11 diabesity 12 metabolic syndrome 13 polycystic ovary syndrome 14 pancreatic polypeptide 15 insulin level 16 resistin 17 neuropeptide y 18 bone mineral density 19 cck 20 lean 21 neuropeptide 22 glucagon http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/show_sentences.cgi Start A-Literature C-Literature B-list Filter Literature AB literature B-term BC literature food intake glp-1 Obestatin and ghrelin and pe... 1: LESIONS OF AREA POSTREMA AND SUBFORNICAL ORGAN ALTER EXENDIN-4-INDUCED BRAIN ACTIVATION WITHOUT PREVENTING THE HYPOPHAGIC EFFECT OF THE GLP-1 RECEPTOR AGONIST.2010 Add to clipboard 2: GLP-1 antagonism with exendin (9-39) fails to increase spontaneous meal size in rats.2010 Add to clipboard 3: Hepatic-portal vein infusions of GLP-1 reduce meal size and increase c-Fos expression in the NTS, AP, and CeA in rats.2010 Add to clipboard 4: GLP-1 (7-36)-amide and Exendin-4 stimulate the HPA axis in rodents and humans.2010 Add to clipboard 5: Exenatide reduces food intake and activates the enteric nervous system of the gastrointestinal tract and the dorsal vagal complex of the hindbrain in the rat by a GLP-1 receptor.2010 Add to clipboard 6: GLP-1 playing the role of a gut regulatory compound.2010 Add to clipboard 7: Pharmacological profile of lixisenatide: A new GLP-1 receptor agonist for the treatment of type 2 diabetes.2010 Add to clipboard 8: Chronic Administration of the Glucagon-Like Peptide-1 (GLP-1 ) Analog, Liraglutide, Delays the Onset of Diabetes and Lowers Triglycerides in UCD-T2DM Rats.2010 Add to clipboard 9: GLP-1 Receptor Stimulation Depresses Heart Rate Variability and Inhibits Neurotransmission to Cardiac Vagal Neurons.2010 Add to clipboard 10: A Novel Human Based Receptor Antagonist of Sustained Action Reveals Body Weight Control by Endogenous GLP-1 .2010 Add to clipboard 11: Central GLP-1 Actions on Energy Metabolism.2010 Add to clipboard 12: GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism.2009 Add to clipboard 13: GLP-1 regulates gastroduodenal motility involving cholinergic pathways.2009 Add to clipboard 14: The effects of GLP-1 infusion in the hepatic portal region on food intake .2009 Add to clipboard 15: Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity.2009 Add to clipboard 16: Hindbrain cocaine- and amphetamine-regulated transcript induces hypothermia mediated by GLP-1 receptors.2009 Add to clipboard 17: Metabolic effects of sustained activation of the GLP-1 receptor alone and in combination with background GIP receptor antagonism in high fat-fed mice.2009 Add to clipboard 18: Constitutive increase in active GLP-1 levels by the DPP4 inhibitor ASP4000 on a new meal tolerance test in Zucker fatty rats.2009 Add to clipboard 19: Poly -GLP-1 , a novel long-lasting glucagon-like peptide-1 polymer, ameliorates hyperglycaemia by improving insulin sensitivity and increasing pancreatic beta-cell proliferation.2009 Add to clipboard 20: A new glucagon and GLP-1 co-agonist eliminates obesity in rodents.2009 Add to clipboard 21: The spectrum of antidiabetic actions of GLP-1 in patients with diabetes.2009 Add to clipboard 22: Glucose lowering and anti-atherogenic effects of incretin-based therapies: GLP-1 analogues and DPP-4-inhibitors.2009 Add to clipboard 23: Glucagon-like peptide-1 (GLP-1 ) inhibits advanced glycation end product (AGE)-induced up-regulation of VCAM-1 mRNA levels in endothelial cells by suppressing AGE receptor (RAGE) expression.2009 Add to clipboard 24: Role and development of GLP-1 receptor agonists in the management of diabetes.2009 Add to clipboard 25: GLP-1 and appetite responses to a meal in lean and overweight adolescents following exercise.2008 Add to clipboard 26: Differential inhibition of galanin- and ghrelin-induced food intake by i.c.v. GLP-1 (7-36)-amide.2008 Add to clipboard 27: GLP-1 suppresses gastrointestinal motility and inhibits the migrating motor complex in healthy subjects and patients with irritable bowel syndrome.2008 Add to clipboard 28: Combination of the insulin sensitizer, pioglitazone, and the long-acting GLP-1 human analog, liraglutide, exerts potent synergistic glucose-lowering efficacy in severely diabetic ZDF rats.2008 Add to clipboard 29: Modulation of taste sensitivity by GLP-1 signaling.2008 Add to clipboard 30: GLP-1 : physiological effects and potential therapeutic applications.2008 Add to clipboard 31: CNS GLP-1 regulation of peripheral glucose homeostasis.2008 Add to clipboard 32: The once-daily human GLP-1 analog, liraglutide, reduces olanzapine-induced weight gain and glucose intolerance.2008 Add to clipboard 33: Physiology of incretins (GIP and GLP-1 ) and abnormalities in type 2 diabetes.2008 Add to clipboard 34: Intestinal hormones and regulation of satiety: the case for CCK, GLP-1 , PYY, and Apo A-IV.2008 Add to clipboard 35: Measuring the effect of a study meal on portal concentrations of glucagon-like peptide 1 (GLP-1 ) in non diabetic and diabetic patients with liver cirrhosis: transjugular intrahepatic portosystemic stent shunt (TIPSS) as a new method for metabolic measurements.2008 Add to clipboard 36: Paying the price for eating ice cream: is excessive GLP-1 signaling in the brain the culprit?2008 Add to clipboard 37: Effects of peripheral or central GLP-1 receptor blockade on leptin-induced suppression of appetite.2008 Add to clipboard 38: Four weeks of near-normalization of blood glucose has no effect on postprandial GLP-1 and GIP secretion, but augments pancreatic B-cell responsiveness to a meal in patients with Type 2 diabetes.2008 Add to clipboard 39: Beneficial effects of sub-chronic activation of glucagon-like peptide-1 (GLP-1 ) receptors on deterioration of glucose homeostasis and insulin secretion in aging mice.2007 Add to clipboard 40: Postprandial glucagon-like peptide-1 (GLP-1 ) response is positively associated with changes in neuronal activity of brain areas implicated in satiety and food intake regulation in humans.2007 Add to clipboard 41: Comparison of the subchronic antidiabetic effects of DPP IV-resistant GIP and GLP-1 analogues in obese diabetic (ob/ob) mice.2007 Add to clipboard 42: Biology of incretins: GLP-1 and GIP.2007 Add to clipboard 43: The GLP-1 agonist exendin-4 reduces food intake in nonhuman primates through changes in meal size.2007 Add to clipboard 44: GLP-1 analogs: satiety without malaise?2007 Add to clipboard 45: 2007 Add to clipboard 46: 2007 Add to clipboard 47: Biliopancreatic diversion in rats is associated with intestinal hypertrophy and with increased GLP-1 , GLP-2 and PYY levels.2007 Add to clipboard 48: Blockade of central GLP-1 receptors prevents CART-induced hypophagia and brain c-Fos expression.2006 Add to clipboard 49: Involvement of CRF on the anorexic effect of GLP-1 in layer chicks.2006 Add to clipboard 50: GLP-1 based therapy for type 2 diabetes.2006 Add to clipboard 51: Novel glucagon-like peptide-1 (GLP-1 ) analog (Val8 )GLP-1 results in significant improvements of glucose tolerance and pancreatic beta-cell function after 3-week daily administration in obese diabetic (ob/ob) mice.2006 Add to clipboard 52: Exogenously imposed postprandial-like rises in systemic glucose and GLP-1 do not produce an incretin effect, suggesting an indirect mechanism of GLP-1 action.2006 Add to clipboard 53: Exenatide: a GLP-1 receptor agonist as novel therapy for Type 2 diabetes mellitus.2006 Add to clipboard 54: Gastrointestinal satiety signals in humans--physiologic roles for GLP-1 and PYY?2006 Add to clipboard 55: Differential hypothalamic neuronal activation following peripheral injection of GLP-1 and oxyntomodulin in mice detected by manganese-enhanced magnetic resonance imaging.2006 Add to clipboard 56: Effects of sub-chronic exposure to naturally occurring N-terminally truncated metabolites of glucose-dependent insulinotrophic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1 ), GIP(3-42) and GLP-1 (9-36)amide, on insulin secretion and glucose homeostasis in ob/ob mice.2006 Add to clipboard 57: Effects of a preload on reduction of food intake by GLP-1 in healthy subjects.2006 Add to clipboard 58: Distribution of proglucagon mRNA and GLP-1 in the brainstem of chicks.2005 Add to clipboard 59: Improvement of metabolic state in an animal model of nutrition-dependent type 2 diabetes following treatment with S 23521, a new glucagon-like peptide 1 (GLP-1 ) analogue.2005 Add to clipboard 60: Glucagon-like peptide 1 (GLP-1 ) in biology and pathology.2005 Add to clipboard 61: Nutrient-stimulated GLP-1 release in normal-weight men and women.2005 Add to clipboard 62: The physiological role of GLP-1 in human: incretin, ileal brake or more?2005 Add to clipboard 63: GIP and GLP-1 as incretin hormones: lessons from single and double incretin receptor knockout mice.2005 Add to clipboard 64: Structure and function studies of glucagon-like peptide-1 (GLP-1 ): the designing of a novel pharmacological agent for the treatment of diabetes.2005 Add to clipboard 65: Enhancing central nervous system endogenous GLP-1 receptor pathways for intervention in Alzheimer's disease.2005 Add to clipboard 66: Biological actions of the incretins GIP and GLP-1 and therapeutic perspectives in patients with type 2 diabetes.2005 Add to clipboard 67: Utilizing the GLP-1 signaling system to treat diabetes: sorting through the pharmacologic approaches.2005 Add to clipboard 68: Glucagon-like peptide 1 (GLP-1 ) secretion and plasma dipeptidyl peptidase IV (DPP-IV) activity in morbidly obese patients undergoing biliopancreatic diversion.2004 Add to clipboard 69: Interaction between GLP-1 and CCK-33 in inhibiting food intake and appetite in men.2004 Add to clipboard 70: Treatment of type 2 diabetes mellitus with agonists of the GLP-1 receptor or DPP-IV inhibitors.2004 Add to clipboard 71: 2004 Add to clipboard 72: Glucagon-like peptide 1 (GLP-1 ) and eating.2004 Add to clipboard 73: A new Alzheimer's disease interventive strategy: GLP-1 .2004 Add to clipboard 74: A recombinant human glucagon-like peptide (GLP)-1-albumin protein (albugon) mimics peptidergic activation of GLP-1 receptor-dependent pathways coupled with satiety, gastrointestinal motility, and glucose homeostasis.2004 Add to clipboard 75: 2004 Add to clipboard 76: Chronic exposure to GLP-1 R agonists promotes homologous GLP-1 receptor desensitization in vitro but does not attenuate GLP-1 R-dependent glucose homeostasis in vivo.2004 Add to clipboard 77: On the physiology of GIP and GLP-1 .2004 Add to clipboard 78: Physiology of GLP-1 --lessons from glucoincretin receptor knockout mice.2004 Add to clipboard 79: Glucagon-like peptide 1 (GLP-1 ) in the treatment of diabetes.2004 Add to clipboard 80: Implementation of GLP-1 based therapy of type 2 diabetes mellitus using DPP-IV inhibitors.2003 Add to clipboard 81: Gastric distension induces c-Fos in medullary GLP-1 /2-containing neurons.2003 Add to clipboard 82: Exendin-4, a GLP-1 receptor agonist, interacts with proteins and their products of digestion to suppress food intake in rats.2003 Add to clipboard 83: Glucagon like peptide-1 (7-36) amide (GLP-1 ) nerve terminals densely innervate corticotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus.2003 Add to clipboard 84: GLP-1 derivative liraglutide in rats with beta-cell deficiencies: influence of metabolic state on beta-cell mass dynamics.2003 Add to clipboard 85: Characterization of GLP-1 effects on beta-cell function after meal ingestion in humans.2003 Add to clipboard 1: The role of maternal gut hormones in normal pregnancy: Fasting plasma active GLP-1 level is a negative predictor of fetal abdomen circumference and maternal weight change.2010 Add to clipboard 2: Differential incretin effects of GIP and GLP-1 on gastric emptying, appetite, and insulin-glucose homeostasis.2010 Add to clipboard 3: The relationship between post-prandial bile acid concentration, GLP-1 , PYY and ghrelin.2010 Add to clipboard 4: Emerging therapies in the treatment of 'diabesity': beyond GLP-1 .2010 Add to clipboard 5: Pharmacokinetics and pharmacodynamic effects of oral GLP-1 and PYY3-36: a proof-of-concept study in healthy subjects.2008 Add to clipboard 6: Intravenous CCK-8, but not GLP-1 , suppresses ghrelin and stimulates PYY release in healthy men.2007 Add to clipboard 7: Gut hormones ghrelin, PYY, and GLP-1 in the regulation of energy balance and metabolism.2006 Add to clipboard
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