2015 年数学高引 Top10 诸平 根据美国数学会《数学评论》引文数据库（ MR Citation Database ）的统计结果，2015年高引论文Top10和高引专著Top10分别摘引如下，供大家参考。 2015 年高引论文 Top10 Search for highly cited articles by year in the MR Citation Database Citations Publication 19 MR3271254 Servadei, Raffaella ; Valdinoci, Enrico The Brezis-Nirenberg result for the fractional Laplacian. Trans. Amer. Math. Soc. 367 (2015), no. 1, 67–102. 17 MR3272924 Guth, Larry ; Katz, Nets Hawk On the Erdős distinct distances problem in the plane. Ann. of Math. (2) 181 (2015), no. 1, 155–190. 16 MR3280032 Cabré, Xavier ; Sire, Yannick Nonlinear equations for fractional Laplacians II: Existence, uniqueness, and qualitative properties of solutions. Trans. Amer. Math. Soc. 367 (2015), no. 2, 911–941. 13 MR3272929 Maynard, James Small gaps between primes. Ann. of Math. (2) 181 (2015), no. 1, 383–413. 11 MR3342661 Ameur, Yacin ; Hedenmalm, Haakan ; Makarov, Nikolai Random normal matrices and Ward identities. Ann. Probab. 43 (2015), no. 3, 1157–1201. 10 MR3335888 Tian, WenYi ; Zhou, Han ; Deng, Weihua A class of second order difference approximations for solving space fractional diffusion equations. Math. Comp. 84 (2015), no. 294, 1703–1727. 9 MR3264768 Chen, Xiuxiong ; Donaldson, Simon ; Sun, Song Kähler-Einstein metrics on Fano manifolds. III: Limits as cone angle approaches 2 π and completion of the main proof. 2 π and completion of the main proof. J. Amer. Math. Soc. 28 (2015), no. 1, 235–278. 8 MR3332942 Brydges, David C. ; Slade, Gordon A renormalisation group method. V. A single renormalisation group step. J. Stat. Phys. 159 (2015), no. 3, 589–667. 7 MR3332941 Brydges, David C. ; Slade, Gordon A renormalisation group method. IV. Stability analysis. J. Stat. Phys. 159 (2015), no. 3, 530–588. 7 MR3332939 Brydges, David C. ; Slade, Gordon A renormalisation group method. II. Approximation by local polynomials. J. Stat. Phys. 159 (2015), no. 3, 461–491. 2015 年高引专著 Top10 Citations Publication 25 MR3307753 Arzhantsev, Ivan ; Derenthal, Ulrich ; Hausen, Jürgen ; Laface, Antonio Cox rings. Cambridge Studies in Advanced Mathematics, 144. Cambridge University Press, Cambridge, 2015. viii+530 pp. ISBN: 978-1-107-02462-5 8 MR3363168 Heinonen, Juha ; Koskela, Pekka ; Shanmugalingam, Nageswari ; Tyson, Jeremy T. Sobolev spaces on metric measure spaces. An approach based on upper gradients. New Mathematical Monographs, 27. Cambridge University Press, Cambridge, 2015. xii+434 pp. ISBN: 978-1-107-09234-1 8 MR3307944 Gradshteyn, I. S. ; Ryzhik, I. M. Table of integrals, series, and products. Translated from the Russian. Translation edited and with a preface by Daniel Zwillinger and Victor Moll. Eighth edition. Revised from the seventh edition . Elsevier/Academic Press, Amsterdam, 2015. xlvi+1133 pp. ISBN: 978-0-12-384933-5 6 MR3287221 Maclagan, Diane ; Sturmfels, Bernd Introduction to tropical geometry. Graduate Studies in Mathematics, 161. American Mathematical Society, Providence, RI, 2015. xii+363 pp. ISBN: 978-0-8218-5198-2 5 MR3328438 Joe, Harry Dependence modeling with copulas. Monographs on Statistics and Applied Probability, 134. CRC Press, Boca Raton, FL, 2015. xviii+462 pp. ISBN: 978-1-4665-8322-1 4 MR3362691 Dehornoy, Patrick Foundations of Garside theory. With François Digne, Eddy Godelle, Daan Krammer and Jean Michel. Contributor name on title page: Daan Kramer. EMS Tracts in Mathematics, 22. European Mathematical Society (EMS), Zürich, 2015. xviii+691 pp. ISBN: 978-3-03719-139-2 4 MR3362184 Banerjee, Sudipto ; Carlin, Bradley P. ; Gelfand, Alan E. Hierarchical modeling and analysis for spatial data. Second edition. Monographs on Statistics and Applied Probability, 135. CRC Press, Boca Raton, FL, 2015. xxii+562 pp. ISBN: 978-1-4398-1917-3 3 MR3330767 Jonsson, Mattias Dynamics of Berkovich spaces in low dimensions. Berkovich spaces and applications, 205–366, Lecture Notes in Math., 2119, Springer, Cham, 2015. 3 MR3307755 Morris, Dave Witte Introduction to arithmetic groups. Deductive Press, Place of publication not identified, 2015. xii+475 pp. ISBN: 978-0-9865716-0-2; 978-0-9865716-1-9 2 MR3330490 Cox, David A. ; Little, John ; O'Shea, Donal Ideals, varieties, and algorithms. An introduction to computational algebraic geometry and commutative algebra. Fourth edition. Undergraduate Texts in Mathematics. Springer, Cham, 2015. xvi+646 pp. ISBN: 978-3-319-16720-6; 978-3-319-16721-3 数论高引 Top10 Citations Publication 1074 MR0817210 Silverman, Joseph H. The arithmetic of elliptic curves. Graduate Texts in Mathematics, 106. Springer-Verlag, New York, 1986. xii+400 pp. ISBN: 0-387-96203-4 851 MR0882550 Titchmarsh, E. C. The theory of the Riemann zeta-function. Second edition. Edited and with a preface by D. R. Heath-Brown. The Clarendon Press, Oxford University Press, New York, 1986. x+412 pp. ISBN: 0-19-853369-1 820 MR1429394 Lidl, Rudolf ; Niederreiter, Harald Finite fields. With a foreword by P. M. Cohn. Second edition. Encyclopedia of Mathematics and its Applications, 20. Cambridge University Press, Cambridge, 1997. xiv+755 pp. ISBN: 0-521-39231-4 742 MR2061214 Iwaniec, Henryk ; Kowalski, Emmanuel Analytic number theory. American Mathematical Society Colloquium Publications, 53. American Mathematical Society, Providence, RI, 2004. xii+615 pp. ISBN: 0-8218-3633-1 613 MR1421575 Washington, Lawrence C. Introduction to cyclotomic fields. Second edition. Graduate Texts in Mathematics, 83. Springer-Verlag, New York, 1997. xiv+487 pp. ISBN: 0-387-94762-0 591 MR1228206 Cohen, Henri A course in computational algebraic number theory. Graduate Texts in Mathematics, 138. Springer-Verlag, Berlin, 1993. xii+534 pp. ISBN: 3-540-55640-0 568 MR0746963 Lidl, Rudolf ; Niederreiter, Harald Finite fields. With a foreword by P. M. Cohn. Encyclopedia of Mathematics and its Applications, 20. Addison-Wesley Publishing Company, Advanced Book Program, Reading, MA, 1983. xx+755 pp. ISBN: 0-201-13519-1 506 MR1312368 Silverman, Joseph H. Advanced topics in the arithmetic of elliptic curves. Graduate Texts in Mathematics, 151. Springer-Verlag, New York, 1994. xiv+525 pp. ISBN: 0-387-94328-5 484 MR0770063 Scharlau, Winfried Quadratic and Hermitian forms. Grundlehren der Mathematischen Wissenschaften , 270. Springer-Verlag, Berlin, 1985. x+421 pp. ISBN: 3-540-13724-6 482 MR1333035 Wiles, Andrew Modular elliptic curves and Fermat's last theorem . Ann. of Math. (2) 141 (1995), no. 3, 443–551.
2013 年 MR 引文数据库（ MR Citation Database ）的 20 篇高引论文（被引 5 次以上）摘录如下，供大家参考。其中 2013 年发表被引最高的是 13 次（ 2 篇），被引 10 次和 9 次的各一篇，被引 8 次和 5 次的个 2 篇，被引 7 次的 3 篇，被引 6 次的 9 篇。具体信息见下表。 Citations Publication 13 MR3060904 Zhou, Yi ; Lei, Zhen Logarithmically improved criteria for Euler and Navier-Stokes equations. Commun. Pure Appl. Anal. 12 (2013), no. 6, 2715–2719. 13 MR3010381 Masmoudi, Nader Global existence of weak solutions to the FENE dumbbell model of polymeric flows. Invent. Math. 191 (2013), no. 2, 427–500. 10 MR3019449 Boucksom, Sébastien ; Demailly, Jean-Pierre ; Păun, Mihai ; Peternell, Thomas The pseudo-effective cone of a compact Kähler manifold and varieties of negative Kodaira dimension. J. Algebraic Geom. 22 (2013), no. 2, 201–248. 9 MR3003676 Bartoszewicz, Artur ; Gła ̧ b, Szymon Strong algebrability of sets of sequences and functions. Proc. Amer. Math. Soc. 141 (2013), no. 3, 827–835. 8 MR2996375 Cartwright, Dustin ; Sturmfels, Bernd The number of eigenvalues of a tensor. Linear Algebra Appl. 438 (2013), no. 2, 942–952. 8 MR2995369 Ruf, Bernhard ; Sani, Federica Sharp Adams-type inequalities in R n . Trans. Amer. Math. Soc. 365 (2013), no. 2, 645–670. 7 MR3032328 Behrend, Kai ; Bryan, Jim ; Szendrői, Balázs Motivic degree zero Donaldson-Thomas invariants. Invent. Math. 192 (2013), no. 1, 111–160. 7 MR3025694 Drábek, Pavel ; Milota, Jaroslav Methods of nonlinear analysis. Applications to differential equations. Second edition. Birkhäuser Advanced Texts: Basler Lehrbücher. Birkhäuser/Springer Basel AG, Basel, 2013. x+649 pp. ISBN: 978-3-0348-0386-1; 978-3-0348-0387-8 7 MR2999038 Miyaoka, Reiko Isoparametric hypersurfaces with ( g , m )=(6,2) . Ann. of Math. (2) 177 (2013), no. 1, 53–110. 6 MR3018041 Gámez-Merino, José L. ; Seoane-Sepúlveda, Juan B. An undecidable case of lineability in R R . J. Math. Anal. Appl. 401 (2013), no. 2, 959–962. 6 MR3017288 Makridakis, Charalambos ; Süli, Endre Finite element analysis of Cauchy-Born approximations to atomistic models. Arch. Ration. Mech. Anal. 207 (2013), no. 3, 813–843. 6 MR3010421 Attouch, Hedy ; Bolte, Jérôme ; Svaiter, Benar Fux Convergence of descent methods for semi-algebraic and tame problems: proximal algorithms, forward-backward splitting, and regularized Gauss-Seidel methods. Math. Program. 137 (2013), no. 1-2, Ser. A, 91–129. 6 MR3010374 Ammari, Habib ; Kang, Hyeonbae ; Lee, Hyundae ; Lim, Mikyoung Enhancement of near cloaking using generalized polarization tensors vanishing structures. Part I: The conductivity problem. Comm. Math. Phys. 317 (2013), no. 1, 253–266. 6 MR3007237 Ballani, Jonas ; Grasedyck, Lars A projection method to solve linear systems in tensor format. Numer. Linear Algebra Appl. 20 (2013), no. 1, 27–43. 6 MR3007147 Hatami, Hamed ; Hladky, Jan ; Kráľ, Daniel ; Norine, Serguei ; Razborov, Alexander On the number of pentagons in triangle-free graphs. J. Combin. Theory Ser. A 120 (2013), no. 3, 722–732. 6 MR3002745 Servadei, Raffaella ; Valdinoci, Enrico Variational methods for non-local operators of elliptic type. Discrete Contin. Dyn. Syst. 33 (2013), no. 5, 2105–2137. 6 MR2996361 Buczyński, Jarosław ; Landsberg, J. M. Ranks of tensors and a generalization of secant varieties. Linear Algebra Appl. 438 (2013), no. 2, 668–689. 6 MR2954043 Lee, John M. Introduction to smooth manifolds. Second edition. Graduate Texts in Mathematics, 218. Springer, New York, 2013. xvi+708 pp. ISBN: 978-1-4419-9981-8 5 MR3073196 Ortner, C. ; Shapeev, A. V. Analysis of an energy-based atomistic/continuum approximation of a vacancy in the 2D triangular lattice. Math. Comp. 82 (2013), no. 284, 2191–2236. 5 MR3048614 Köhne, Matthias ; Prüss, Jan ; Wilke, Mathias Qualitative behaviour of solutions for the two-phase Navier-Stokes equations with surface tension. Math. Ann. 356 (2013), no. 2, 737–792.
Stephen F Altschul ：BLAST算法的奠基者及其他 诸平 美国国家卫生研究院、国家医学图书馆、国家生物技术信息中心斯蒂芬·阿尔丘尔（ Stephen F Altschul ）等人在 1990 年提出 BLAST 算法， BLAST 是 基于局部比对算法的搜索工具英文全称（ Basic Local Alignment Search Tool ）的首字母缩写。 BLAST 算法是一种基于局部序列比对的序列比对算法， 能够实现比较两段核酸或者蛋白序列之间的同源性的功能，它能够快速的找到两段序列之间的同源序列并对比对区域进行打分以确定同源性的高低。因此 广泛被用于蛋白质 DNA 序列的分析问题中，在其他序列相似性比对中也有应用。对于 斯蒂芬·阿尔丘尔进行简要介绍，并对其发表的论文高引情况进行搜索统计。 1 斯蒂芬·阿尔丘尔 （ Stephen F Altschul ） 简介 斯蒂芬·弗兰克·阿尔丘尔（ Stephen Frank Altschul ） 1957 年 2 月 28 日出生 ，他是一位美国数学家，设计的算法被广泛应用于生物信息学领域 ( Karlin-Altschul 算法 及其 继任算法 ） 。最值得注意的是用于蛋白质和核苷酸的序列分析 的 BLAST 算法（ BLAST algorithm ），阿尔丘尔就是合著者之一。 阿尔丘尔 1975 年 9 月进入哈佛学院（ Harvard College ）学习数学， 1979 年 6 月大学毕业获数学学士学位，在哈佛期间他被选入美国大学优等生荣誉学会数学组成员。阿尔丘尔以优异的成绩从哈佛毕业之后， 1981 年 9 月进入美国麻省理工学院 ( Massachusetts Institute of Technology ) ，攻读博士学位， 导师是 Daniel Kleitman ， 1987 年 6 月毕业获得数学博士学位。但是据 PubMed 数据库介绍，斯蒂芬·阿尔丘尔 1985-2006 年一直在美国马里兰州贝塞斯达市（ Bethesda, Maryland ）的美国糖尿病、消化以及肾病研究所数学研究部工作。 1994 年 4 月至今在美国国立卫生研究院（ NIH ） 国家生物信息中心（ NCBI ）的计算生物学部工作，任高级研究员（ Senior Investigator ）。主要从事序列比对算法、统计序列比较、序列相似性的测算等研究。开放存储（ OA ）文献中有 16 篇高引文献。 本科期间年 , 阿尔丘尔博士就对生物学产生了浓厚的兴趣。因此 , 他开始阅读有关 DNA 的书籍。在他阅读的书籍中就有詹姆斯· 沃森（ Watson ）撰写的 《双螺旋——发现DNA结构的故事》 （ The Double Helix ）。此外 , 他还选修了《进化生物学》（ Evolutionary Biology ）课程。阿尔丘尔博士在洛克菲勒大学（ Rockfeller University ）实验室度过了两个炎热的夏季，他帮助为 x 射线晶体学项目编写计算机代码。由于他对生物学的兴趣，经过深思熟虑之后他打算申请研究生院的生物学研究。他决定申请应用数学的编程 , 希望找到一些将数学应用于生物学的方法。 博士毕业后 , 阿尔丘尔在美国国家糖尿病、消化和肾脏疾病研究所（ National Institute of Diabetes and Digestive and Kidney Diseases ）数学研究部，作为一名 IRTA 博士后研究员从事数学研究。从 1990 年至今 , 他一直在美国国家生物技术信息中心（ NCBI ）计算生物学部工作 ,1994年至今在 NCBI 计算生物部任 高级研究员。 Stephen Altschul, PhD Altschul, S F (Stephen F Altschul ) — Bethesda, USA 16 highly cited papers in open-access literature. Mathematical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, Bethesda, Maryland 20892. Contact Information Building 38A, Room 6N605 8600 Rockville Pike, MSC 6075 Bethesda, MD 20894-6075 altschul@ncbi.nlm.nih.gov Computational Biology Branch, NCBI , NLM , NIH Research Interests ： Sequence alignment algorithms; Statistics of sequence comparison; Measures of sequence similarity 2 部分近期出版物以及PubMed数据库收录情况 1985-2013 年 PubMed 数据库收录了 53 篇论文 ，近期的几篇重要论文摘引如下： Altschul, S.F., Wootton, J.C., Zaslavsky, E. Yu, Y.-K. (2010) “The construction and use of log-odds substitution scores for multiple sequence alignment,” PLoS Comput. Biol. 6:e1000852. Ye, X., Yu, Y.-K. Altschul, S.F. (2010) “Compositional adjustment of Dirichlet mixture priors,” J. Comput. Biol. 17:1607-1620. Yu, Y.-K. Altschul, S.F. (2011) “The complexity of the Dirichlet model for multiple alignment data,” J. Comput. Biol. 18:925-939. Ye, X., Yu, Y.-K. Altschul, S.F. (2011) “On the inference of Dirichlet mixture priors for protein sequence comparison,” J. Comput. Biol. 18:941-954. Publications in PubMed 3. 斯蒂芬·阿尔丘尔的H指数 谷歌学术搜索结果显示(截止2013年11月27日)， 阿尔丘尔发表的 74 篇论文，累计被引 115883 次， 2008 年以来被引 45724 次， H 指数 44 ；被引 10 次或者以上的论文 58 篇，其中 2008 年以来的有 49 篇， 1992-2013 年的逐年被引频次见以下图示。 4. 斯蒂芬·阿尔丘尔 及BLAST研究 高引论文（1000次/篇） 通过谷歌学术搜索，斯蒂芬·阿尔丘尔论文中被引频次最高的不是他 1990 年关于 BLAST 的研究论文，而是他与同僚合作完成的 1997 年发表于《核酸研究》（ Nucleic Acids Research ）的论文—— Stephen F. Altschul , Thomas L. Madden , Alejandro A. Schäffer , Jinghui Zhang , Zheng Zhang , Webb Miller and David J. Lipman . Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucl. Acids Res. 1997, 25(17): 3389-3402. doi: 10.1093/nar/25.17.3389 . 累计被引用 48771 次，其次才是 SF Altschul, W Gish, W Miller, EW Myers, DJ Lipman. Basic local alignment search tool . Journal of Molecular Biology ， 1990 ， 215 (3) ： 403-410. 累计被引用 48148 次，其他被引用在千次以上的论文同时包括其他人关于 BLAST 算法研究相关论文，引用情况摘录如下： Basic local alignment search tool SF Altschul , W Gish, W Miller, EW Myers… - Journal of molecular …, 1990 – Elsevier A new approach to rapid sequence comparison, basic local alignment search tool (BLAST), directly approximates alignments that optimize a measure of local similarity, the maximal segment pair (MSP) score. Recent matlmmatical results on the stochastic properties of … 被引用次数： 48148 相关文章 所有 98 个版本 引用 Gapped BLAST and PSI-BLAST: a new generation of protein database search programs SF Altschul , TL Madden, AA Schäffer… - Nucleic acids …, 1997 – Oxford Univ Press Abstract The BLAST programs are widely used tools for searching protein and DNA databases for sequence similarities. For protein comparisons, a variety of definitional, algorithmic and statistical refinements described here permits the execution time of the … 被引用次数： 48771 相关文章 所有 295 个版本 引用 BLAT—the BLAST -like alignment tool WJ Kent - Genome research, 2002 - genome.cshlp.org Abstract Analyzing vertebrate genomes requires rapid mRNA/DNA and cross-species protein alignments. A new tool, BLAT, is more accurate and 500 times faster than popular existing tools for mRNA/DNA alignments and 50 times faster for protein alignments at ... 被引用次数： 3715 相关文章 所有 41 个版本 引用 Detecting subtle sequence signals: a Gibbs sampling strategy for multiple alignment CE Lawrence, SF Altschul , MS Boguski, JS Liu… - science, 1993 – sciencemag.org Abstract A wealth of protein and DNA sequence data is being generated by genome projects and other sequencing efforts. A crucial barrier to deciphering these sequences and understanding the relations among them is the difficulty of detecting subtle local residue … 被引用次数： 1838 相关文章 所有 58 个版本 引用 BLAST 2 Sequences, a new tool for comparing protein and nucleotide sequences TA Tatusova, TL Madden - FEMS microbiology letters, 1999 - Wiley Online Library Abstract ' BLAST 2 S equences', a new BLAST -based tool for aligning two protein or nucleotide sequences, is described. While the standard BLAST program is widely used to search for homologous sequences in nucleotide and protein databases, one often needs ... 被引用次数： 1673 相关文章 所有 21 个版本 引用 Methods for assessing the statistical significance of molecular sequence features by using general scoring schemes S Karlin, SF Altschul - … of the National Academy of Sciences, 1990 – National Acad Sciences Abstract An unusual pattern in a nucleic acid or protein sequence or a region of strong similarity shared by two or more sequences may have biological significance. It is therefore desirable to know whether such a pattern can have arisen simply by chance. To identify … 被引用次数： 1550 相关文章 所有 27 个版本 引用 A workbench for multiple alignment construction and analysis GD Schuler, SF Altschul … - … : Structure, Function, and …, 1991 – Wiley Online Library Abstract Multiple sequence alignment can be a useful technique for studying molecular evolution, as well as for analyzing relationships between structure or function and primary sequence. We have developed for this purpose an interactive program, MACAW (Multiple … 被引用次数： 1022 相关文章 所有 4 个版本 引用 微软学术搜索结果有所不同（被引千次以上的几篇论文如下） apped BLAST and PSI-BLAST: a new generation of protein database search programs ( Citations: 25606 ) Stephen F. Altschul , Thomas L. Madden , Alejandro A. Schäffer , Jinghui Zhang , Zheng Zhang , Webb C. Miller , David J. Lipman The BLAST programs are widely used tools for searching protein and DNA databases for sequence similarities. For protein comparisons, a variety of definitional, algorithmic and statistical refinements described here permits the execution time of the BLAST programs to be decreased substantially while enhancing their sensitivity to weak similarities. A new criterion for triggering the extension of word hits, combined with ... Journal: Nucleic Acids Research - NAR , vol. 25, no. 17, pp. 3389-3402, 1997 Basic local alignment search tool ( Citations: 21081 ) Stephen F. Altschul , Warren Gish , Webb C. Miller , Eugene W. Myers , David J. Lipman A new approach to rapid sequence comparison, basic local alignment search tool (BLAST),directly approsimates alignments that optimize a measure of local similarity, the maximal segment pair (3ISP) score. Recent mathematical results on the stochastic properties of MSP scores allow an anallrsis of the performance of this method as well as the statistical significance of alignments it generates. The basic ... Journal: Nucleic Acids Research - NAR , 1990 Basic Local Alignment Search Tool ( Citations: 4678 ) S Altschul Journal: Journal of Molecular Biology - J MOL BIOL , vol. 215, no. 3, pp. 403-410, 1990 5. PubMed 数据库合作者关系图 6. 1985-2013 年53篇论文年度分布
1. 两篇颇具影响力的综述性论文 Douglas Hanahan 和 Robert A Weinberg 在 2000年发表在 Cell 上的《 The hallmarks of cancer 》累计被引用已经仅1.2万次（ Scopus ），谷歌学术搜索近1.8万次；几乎是每一位从事癌症研究的科研人员的必读的 经典综述性 文献 。但是11年之后，二位合作有撰写了一篇新的癌症研究综述性文献，2011年3月4日在 Cell 发表，题为《 Hallmarks of Cancer: The Next Generation 》，将肿瘤的六种武器扩充到十种武器。不同数据库的引用统计结果如下： 1） The Hallmarks of Cancer • Review article Cell, Volume 100, Issue 1, January 2000, Pages 57-70 Hanahan, D.; Weinberg, R.A. Cited by Scopus (11879) 2） Hallmarks of Cancer: The Next Generation • Review article Cell, Volume 144, Issue 5, March 2011, Pages 646-674 Hanahan, D.; Weinberg, Robert A. Cited by Scopus (3708) The hallmarks of cancer D Hanahan, RA Weinberg - cell, 2000 - Cell Press 被引用次数：17676 相关文章 所有 94 个版本 引用 sciencedirect.com 中的 Hallmarks of cancer : the next generation D Hanahan, RA Weinberg - Cell, 2011 - Elsevier The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors. The hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic disease. They include sustaining proliferative ... 被引用次数：5597 相关文章 所有 51 个版本 引用 2 Robert A Weinberg 和 Douglas Hanahan 的高引论文（被引千次以上） 2.1 Robert A Weinberg ： 美国科学院院士，世界着名的 Whitehead 研究所创始人之一，他曾发现了第一个人类癌基因 Ras 和第一个抑癌基因 Rb ，他的一系列杰出研究工作已经成为肿瘤研究领域乃至整个医学生物学领域的重要里程碑。 The hallmarks of cancer D Hanahan, RA Weinberg - cell, 2000 - Cell Press 被引用次数： 17676 相关文章 所有 94 个版本 引用 ncsu.edu 中的 The retinoblastoma protein and cell cycle control RA Weinberg - Cell, 1995 - Cell Press 被引用次数： 4135 相关文章 所有 5 个版本 引用 sciencedirect.com 中的 Hallmarks of cancer: the next generation D Hanahan, RA Weinberg - Cell, 2011 - Elsevier The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors. The hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic disease. They include sustaining proliferative ... 被引用次数： 5597 相关文章 所有 51 个版本 引用 Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. H Land, LF Parada, RA Weinberg - Nature, 1982 - europepmc.org Transfection of embryo fibroblasts by a human ras oncogene does not convert them into tumour cells unless the fibroblasts are established and immortalized before transfection. The embryo fibroblasts become tumorigenic if a second oncogene such as a viral or cellular ... 被引用次数： 2527 相关文章 所有 10 个版本 引用 更多 uu.nl 中的 Identification of a human DNA segment having properties of the gene that predisposes to retinoblastoma and osteosarcoma SH Friend, RA Bernards, S Rogelj, RA Weinberg … - …, 1986 - igitur-archive.library.uu.nl The genomes of various tumor cells contain mutant oncogenes that act dominantly, in that their effects can be observed when they are introduced into non-malignent cells. There is evidence for another class of oncogenes, in which tumour-predisposing mutations are ... 被引用次数： 2442 相关文章 所有 9 个版本 引用 Creation of human tumour cells with defined genetic elements …, RL Beijersbergen, MW Brooks, RA Weinberg - Nature, 1999 - nature.com Abstract During malignant transformation, cancer cells acquire genetic mutations that override the normal mechanisms controlling cellular proliferation. Primary rodent cells are efficiently converted into tumorigenic cells by the coexpression of cooperating oncogenes ... 被引用次数： 1926 相关文章 所有 7 个版本 引用 sciencedirect.com 中的 The epithelial-mesenchymal transition generates cells with properties of stem cells …, K Polyak, C Brisken, J Yang, RA Weinberg - Cell, 2008 - Elsevier The epithelial-mesenchymal transition (EMT) is a key developmental program that is often activated during cancer invasion and metastasis. We here report that the induction of an EMT in immortalized human mammary epithelial cells (HMLEs) results in the acquisition of ... 被引用次数： 2443 相关文章 所有 34 个版本 引用 Tumor suppressor genes RA Weinberg - Science, 1991 - sciencemag.org Abstract For the past decade, cellular oncogenes have attracted the attention of biologists intent on understanding the molecular origins of cancer. As the present decade unfolds, oncogenes are yielding their place at center stage to a second group of actors, the tumor ... 被引用次数： 1609 相关文章 所有 6 个版本 引用 sciencedirect.com 中的 i hEST2/i, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization …, Q Liu, S Bacchetti, DA Haber, RA Weinberg - cell, 1997 - Elsevier Telomerase, the ribonucleoprotein enzyme that elongates telomeres, is repressed in normal human somatic cells but is reactivated during tumor progression. We report the cloning of a human gene, hEST2, that shares significant sequence similarity with the telomerase ... 被引用次数： 1844 相关文章 所有 6 个版本 引用 sciencedirect.com 中的 Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis …, P Savagner, I Gitelman, A Richardson, RA Weinberg - Cell, 2004 - Elsevier Metastasis is a multistep process during which cancer cells disseminate from the site of primary tumors and establish secondary tumors in distant organs. In a search for key regulators of metastasis in a murine breast tumor model, we have found that the ... 被引用次数： 1843 相关文章 所有 6 个版本 引用 Association between an oncogene and an anti-oncogene: the adenovirus E 1 A proteins bind to the retinoblastoma gene product …, SH Friend, M Raybuck, RA Weinberg … - …, 1988 - staging-www.nature.com One of the cellular targets implicated in the process of transformation by the adenovirus EIA proteins is a 105K cellular protein. Previously, this protein had been shown to form stable protein/protein complexes with the EIA polypeptides but its identity was unknown. Here, ... 被引用次数： 1300 相关文章 所有 7 个版本 引用 scottsdalecc.edu 中的 Foundations of sport and exercise psychology RS Weinberg , D Gould - 2010 - books.google.com The latest edition of the best-selling sport and exercise psychology book on the market, Foundations of Sport and Exercise Psychology, Fifth Edition, provides a thorough introduction to the key concepts in the field. Written by internationally respected authors, it ... 被引用次数： 1751 相关文章 所有 10 个版本 引用 stanford.edu 中的 Effects of an Rb mutation in the mouse …, EM Schmitt, RT Bronson, MA Goodell, RA Weinberg - Nature, 1992 - stanford.edu The retinoblastoma gene is mutated in several types of human cancer and is the best characterized of the tumour-suppressor genes. A mouse strain has been constructed in which one allele of Rb is disrupted. These heterozygous animals are not predisposed to ... 被引用次数： 1565 相关文章 所有 8 个版本 引用 sciencedirect.com 中的 i hSIR2SIRT1/i Functions as an NAD-Dependent p53 Deacetylase …, RA Frye, TK Pandita, L Guarente, RA Weinberg - Cell, 2001 - Elsevier DNA damage-induced acetylation of p53 protein leads to its activation and either growth arrest or apoptosis. We show here that the protein product of the gene hSIR2SIRT1, the human homolog of the S. cerevisiae Sir2 protein known to be involved in cell aging and in ... 被引用次数： 1623 相关文章 所有 10 个版本 引用 sciencedirect.com 中的 Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion …, R Naeem, VJ Carey, AL Richardson, RA Weinberg - Cell, 2005 - Elsevier Fibroblasts often constitute the majority of the stromal cells within a breast carcinoma, yet the functional contributions of these cells to tumorigenesis are poorly understood. Using a coimplantation tumor xenograft model, we demonstrate that carcinoma-associated ... 被引用次数： 1635 相关文章 所有 6 个版本 引用 Tumor spectrum analysis in i p53/i-mutant mice …, EM Schmitt, S Halachmi, RT Bronson, RA Weinberg - Current Biology, 1994 - Elsevier Background: The p53 tumor suppressor gene is mutated in a large percentage of human malignancies, including tumors of the colon, breast, lung and brain. Individuals who inherit one mutant allele of p53 are susceptible to a wide range of tumor types. The gene ... 被引用次数： 1458 相关文章 所有 5 个版本 引用 nih.gov 中的 The basics of epithelial-mesenchymal transition R Kalluri, RA Weinberg - The Journal of clinical investigation, 2009 - ncbi.nlm.nih.gov Abstract The origins of the mesenchymal cells participating in tissue repair and pathological processes, notably tissue fibrosis, tumor invasiveness, and metastasis, are poorly understood. However, emerging evidence suggests that epithelial-mesenchymal ... 被引用次数： 1546 相关文章 所有 8 个版本 引用 Cellular oncogenes and multistep carcinogenesis H Land, LF Parada, RA Weinberg - Science, 1983 - sciencemag.org Abstract Two dozen cellular proto-oncogenes have been discovered to date through the study of retroviruses and the use of gene transfer. They form a structurally and functionally heterogeneous group. At least five distinct mechanisms are responsible for their ... 被引用次数： 1120 相关文章 所有 4 个版本 引用 lumc.nl 中的 Mesenchymal stem cells within tumour stroma promote breast cancer metastasis …, AL Richardson, K Polyak, R Tubo, RA Weinberg - Nature, 2007 - nature.com Abstract Mesenchymal stem cells have been recently described to localize to breast carcinomas, where they integrate into the tumour-associated stroma. However, the involvement of mesenchymal stem cells (or their derivatives) in tumour pathophysiology ... 被引用次数： 1331 相关文章 所有 13 个版本 引用 The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen …, SJ Decker, JA Drebin, MI Greene, RA Weinberg - 1984 - nature.com A series of rat neuro/glioblastomas all contain the same transforming gene (neu) which induces synthesis of a tumour antigen of relative molecular mass (M r) 185,000 (p185). The neu oncogene bears homology to erb-B and the tumour antigen, p185, is serologically ... 被引用次数： 1011 相关文章 所有 6 个版本 引用 Tumour invasion and metastasis initiated by microRNA-10b in breast cancer L Ma, J Teruya-Feldstein, RA Weinberg - Nature, 2007 - nature.com Abstract MicroRNAs have been implicated in regulating diverse cellular pathways. Although there is emerging evidence that some microRNAs can function as oncogenes or tumour suppressors, the role of microRNAs in mediating cancer metastasis remains unexplored. ... 被引用次数： 1307 相关文章 所有 14 个版本 引用 Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation …, MW Brooks, L Buday, AM Sizeland, RA Weinberg - 1993 - nature.com The proteins Grb2–Sem-5, Shc and Sos have been implicated in the signalling pathway from tyrosine kinase receptors to Ras. Grb2–Sem-5 binds directly to murine Sos1, a Ras exchange factor, through two SH3 domains. Sos is also associated with ligand-activated ... 被引用次数： 1051 相关文章 所有 6 个版本 引用 The neu oncogene encodes an epidermal growth factor receptor-related protein CI Bargmann, MC Hung, RA Weinberg - 1986 - nature.com The neu oncogene is repeatedly activated in neuro-and glioblastomas derived by transplacental mutagenesis of the BDIX strain of rat with ethylnitrosourea 1. Foci induced by the DNAs from such tumours on NIH 3T3 cells contain the neu oncogene and an ... 被引用次数： 1104 相关文章 所有 5 个版本 引用 aacrjournals.org 中的 Oncogenes, antioncogenes, and the molecular bases of multistep carcinogenesis RA Weinberg - Cancer Research, 1989 - AACR Tumorigenesis in humans and laboratory animals is a com plex, mu11ÂĄstepprocess (1, 2). In humans, in whom the process has been studied only indirectly, measurements of age- depen dent tumor incidence indicate kinetics dependent on the fifth or sixth power of ... 被引用次数： 1005 相关文章 所有 5 个版本 引用 2.2 Hanahan, D — San Francisco, USA 3 highly cited papers in open-access literature. URL to this profile Department of Biochemistry and Biophysics, University of California, San Francisco 94143-0534. Cold Spring Harbor Laboratory, New York 11724. The hallmarks of cancer D Hanahan , RA Weinberg - cell, 2000 - Cell Press 被引用次数：17676 相关文章 所有 94 个版本 引用 protocol-online.org 中的 Studies on transformation of i Escherichia coli/i with plasmids D Hanahan - Journal of molecular biology, 1983 - Elsevier Factors that affect the probability of genetic transformation of Escherichia coli by plasmids have been evaluated. A set of conditions is described under which about one in every 400 plasmid molecules produces a transformed cell. These conditions include cell growth in ... 被引用次数：10000 相关文章 所有 7 个版本 引用 Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis D Hanahan , J Folkman - cell, 1996 - Cell Press 被引用次数：6172 相关文章 所有 6 个版本 引用 sciencedirect.com 中的 Hallmarks of cancer: the next generation D Hanahan , RA Weinberg - Cell, 2011 - Elsevier The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors. The hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic disease. They include sustaining proliferative ... 被引用次数：5597 相关文章 所有 51 个版本 引用 nih.gov 中的 Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis …, P Thorpe, S Itohara, Z Werb, D Hanahan - Nature cell …, 2000 - nature.com Abstract During carcinogenesis of pancreatic islets in transgenic mice, an angiogenic switch activates the quiescent vasculature. Paradoxically, vascular endothelial growth factor (VEGF) and its receptors are expressed constitutively. Nevertheless, a synthetic inhibitor ( ... 被引用次数：1888 相关文章 所有 9 个版本 引用 harvard.edu 中的 Induction of angiogenesis during the transition from hyperplasia to neoplasia J Folkman, K Watson, D Ingber, D Hanahan - Nature, 1989 - web1.tch.harvard.edu It is now well established that unrestricted growth of tumours is dependent upon angiogenesis1, 2. Previous studies on tumour growth, however, have not revealed when or how the transition to an angiogenic state occurs during early tumour development. The ... 被引用次数：1863 相关文章 所有 8 个版本 引用 Techniques for transformation of E. coli D Hanahan - DNA cloning, 1985 被引用次数：1530 相关文章 引用 sciencedirect.com 中的 MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes …, G Bergers, JE Berger, JA Helms, D Hanahan … - Cell, 1998 - Elsevier Homozygous mice with a null mutation in the MMP-9/gelatinase B gene exhibit an abnormal pattern of skeletal growth plate vascularization and ossification. Although hypertrophic chondrocytes develop normally, apoptosis, vascularization, and ossification are delayed, ... 被引用次数：1375 相关文章 所有 7 个版本 引用 Heritable formation of pancreatic β-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes D Hanahan - Nature, 1985 - nature.com Abstract Following the transfer into fertilized mouse eggs of recombinant genes composed of the upstream region of the rat insulin II gene linked to sequences coding for the large-T antigen of simian virus 40, large-T antigen is detected exclusively in the beta-Cells of the ... 被引用次数：1141 相关文章 所有 5 个版本 引用 akadns.net 中的 Signaling vascular morphogenesis and maintenance D Hanahan - SCIENCE-NEW YORK THEN WASHINGTON-, 1997 - columbia.akadns.net Blood vessels are constructed by two processes: vasculogenesis, whereby a primitive vascular network is established during embryogenesis from multipotential mesenchymal progenitors, and angiogenesis, in which preexisting vessels (both in embryo and adult) ... 被引用次数：1164 相关文章 所有 21 个版本 引用 更多 Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors …, E Bergsland, D Hanahan - Journal of Clinical …, 2003 - Am Soc Clin Investig Methods Drug treatment of transgenic mice. The mice in these studies were males and females of the RIP1Tag2 transgenic mouse lineage that were bred 45 generations into the C57Bl/6J background. Animals were treated from 5 to 10.5 weeks of age in the prevention ... 被引用次数： 1109 相关文章 所有 7 个版本 引用 sciencedirect.com 中的 Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis …, H Okuyama, F Viñals, M Inoue, G Bergers, D Hanahan … - Cancer cell, 2009 - Elsevier Multiple angiogenesis inhibitors have been therapeutically validated in preclinical cancer models, and several in clinical trials. Here we report that angiogenesis inhibitors targeting the VEGF pathway demonstrate antitumor effects in mouse models of pancreatic ... 被引用次数： 1120 相关文章 所有 18 个版本 引用 Modes of resistance to anti-angiogenic therapy G Bergers, D Hanahan - Nature Reviews Cancer, 2008 - nature.com Abstract Angiogenesis inhibitors targeting the vascular endothelial growth factor (VEGF) signalling pathways are affording demonstrable therapeutic efficacy in mouse models of cancer and in an increasing number of human cancers. However, in both preclinical and ... 被引用次数： 1045 相关文章 所有 10 个版本 引用 3. Robert A Weinberg 和 Douglas Hanahan 的合作者关系图 3.1 Robert A Weinberg 合作者关系图 3.2 Douglas Hanahan 合作者关系图
2012年度诺贝尔化学奖已经于北京时间10月10日17:45公布，由于在“G蛋白偶联受体”方面所作出的突破性贡献，今年的化学奖项授予美国科学家罗伯特·洛夫科维茨(Robert J. Lefkowitz)以及布莱恩·克比尔卡(Brian K. Kobilka)。 布莱恩·克比尔卡于1955年出生于美国明尼苏达州小瀑布城，于1981年在美国耶鲁大学医学院获得硕士学位。目前担任美国斯坦福大学医学院医学教授以及分子和细胞生物学教授。 根据GOOGLE SCHOLAR搜索结果，在1.24万条相关信息中，被引频次较高（600次）的几篇论文摘录如下，供大家参考。 其中2007年发表于"Science"的论文，累计被引用1502次，其他高引论文见下: High-resolution crystal structure of an engineered human 2-adrenergic G protein coupled receptor …, HJ Choi, P Kuhn, WI Weis, BK Kobilka … - Science …, 2007 - stke.sciencemag.org Abstract: Heterotrimeric guanine nucleotide–binding protein (G protein)–coupled receptors constitute the largest family of eukaryotic signal transduction proteins that communicate across the membrane. We report the crystal structure of a human β 2-adrenergic receptor– ... Cited by 1502 Related articles All 36 versions from anl.gov anl.gov Crystal structure of the human bgr; 2 adrenergic G-protein-coupled receptor …, RF Fischetti, GFX Schertler, WI Weis, BK Kobilka - Nature, 2007 - nature.com Abstract Structural analysis of G-protein-coupled receptors (GPCRs) for hormones and neurotransmitters has been hindered by their low natural abundance, inherent structural flexibility, and instability in detergent solutions. Here we report a structure of the human ... Cited by 978 Related articles BL Direct All 20 versions from diyhpl.us diyhpl.us Cloning of the gene and cDNA for mammalian -adrenergic receptor and homology with rhodopsin RAF Dixon, BK Kobilka , DJ Strader, JL Benovic… - Nature, 1986 - diyhpl.us The adenylate cyclase system, which consists of a catalytic moiety and regulatory guanine nucleotide-binding proteins, provides the effector mechanism for the intracellular actions of many hormones and drugs'. The tissue specificity of the system is determined by the ... Cited by 929 Related articles All 6 versions involved in effector coupling and ligand binding specificity. BK Kobilka , TS Kobilka , K Daniel, JW Regan… - Science, 1988 - fisfar.ufc.br THE ADRENERGIC RECEPTORS ( . sub. 1.-, . sub. 2.-, . sub. 1.-, AND . sub. 2.-), which mediate the physiological effects of catecholamines, belong to the family of plasma membrane receptors that are coupled to guanine nucleotide regulatory ... Cited by 672 Related articles View as HTML All 10 versions Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor. BK Kobilka , H Matsui, TS Kobilka … - Science (New York, …, 1987 - ukpmc.ac.uk The gene for the human platelet alpha 2-adrenergic receptor has been cloned with oligonucleotides corresponding to the partial amino acid sequence of the purified receptor. The identity of this gene has been confirmed by the binding of alpha 2-adrenergic ligands ... Cited by 666 Related articles Cached All 7 versions from stanford.edu stanford.edu GPCR engineering yields high-resolution structural insights into 2-adrenergic receptor function …, XJ Yao, WI Weis, RC Stevens, BK Kobilka - Science …, 2007 - stke.sciencemag.org Abstract: The β 2-adrenergic receptor (β 2 AR) is a well-studied prototype for heterotrimeric guanine nucleotide–binding protein (G protein)–coupled receptors (GPCRs) that respond to diffusible hormones and neurotransmitters. To overcome the structural flexibility of the β 2 ... Cited by 652 Related articles All 12 versions from pnas.org pnas.org cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared … BK Kobilka , RA Dixon, T Frielle… - Proceedings of the …, 1987 - National Acad Sciences Abstract We have isolated and sequenced a cDNA encoding the human beta 2-adrenergic receptor. The deduced amino acid sequence (413 residues) is that of a protein containing seven clusters of hydrophobic amino acids suggestive of membrane-spanning domains. ... Cited by 601 Related articles All 11 versions
2012年度诺贝尔化学奖已经于北京时间10月10日17:45公布，由于在“G蛋白偶联受体”方面所作出的突破性贡献，今年的化学奖项授予美国科学家罗伯特·洛夫科维茨(Robert J. Lefkowitz)以及布莱恩·克比尔卡(Brian K. Kobilka)。 罗伯特·洛夫科维茨于1943年出生于美国纽约，于1966年在美国哥伦比亚大学获得硕士学位。目前担任美国霍华德·休斯医学研究所研究员，并在美国杜克大学医学中心担任詹姆斯·杜克医学教授，生物化学教授。 根据GOOGLE SCHOLAR搜索结果，在5.48万条相关信息中，被引频次较高（1000次）的几篇论文摘录如下，供大家参考。 其中2002年发表于" Nature Reviews Molecular Cell Biology "的论文，累计被引用1255次，其他高引论文见下: Turning off the signal: desensitization of beta-adrenergic receptor function. WP Hausdorff, MG Caron, RJ Lefkowitz - The FASEB Journal, 1990 - FASEB Abstract Cellular responses to many hormones and neurotransmitters wane rapidly despite continuous exposure of cells to these stimuli. This phenomenon, termed desensitization, has been particularly well studied for the stimulation of cAMP levels by plasma membrane ... Cited by 1087 Related articles All 6 versions Model systems for the study of seven-transmembrane-segment receptors …, J Thorner, MG Caron, RJ Lefkowitz - Annual review of …, 1991 - annualreviews.org The past few years have been an exciting period in the field of receptor biology as remarkable similarities among various signal transduction systems have been revealed. Many such transmembrane signaling systems consist of three membrane-bound protein ... Cited by 1250 Related articles All 4 versions from jbc.org jbc.org A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor. A De Lean, JM Stadel, RJ Lefkowitz - Journal of Biological Chemistry, 1980 - ASBMB Abstract The unique properties of agonist binding to the frog erythrocyte beta-adrenergic receptor include the existence of two affinity forms of the receptor. The proportion and relative affinity of these two states of the receptor for ligands varies with the intrinsic activity ... Cited by 1188 Related articles All 4 versions from barbiotech.it barbiotech.it Seven-transmembrane receptors KL Pierce, RT Premont, RJ Lefkowitz - Nature Reviews Molecular Cell …, 2002 - nature.com Abstract Seven-transmembrane receptors, which constitute the largest, most ubiquitous and most versatile family of membrane receptors, are also the most common target of therapeutic drugs. Recent findings indicate that the classical models of G-protein coupling and ... Cited by 1255 Related articles BL Direct All 21 versions from jbc.org jbc.org A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model. …, S Cotecchia, T Costa, RJ Lefkowitz - Journal of Biological …, 1993 - ASBMB Abstract We have replaced the C-terminal portion of the third intracellular loop of the beta 2- adrenergic receptor (residues 266-272) with the homologous region of the alpha 1B- adrenergic receptor. In a fashion analogous to the reciprocal mutations of the alpha 1B ... Cited by 1056 Related articles BL Direct All 4 versions PubMed收录141篇，其年度分布见下图：
根据GOOGLE SCHOLAR搜索结果，在1.19万条相关信息中，被引频次较高（320次）的几篇摘录如下，供大家参考。 其中1971年发表于"Nature"的论文，累计被引用598次，其他高引论文见下: Use of frog eggs and oocytes for the study of messenger RNA and its translation in living cells JB Gurdon , CD Lane, HR Woodland - Nature, 1971 - adsabs.harvard.edu Abstract Injected frog eggs and oocytes provide a very sensitive assay system for the identification of messenger RNA and permit the study of translational control in living cells. The translation of each haemoglobin messenger RNA molecule once every 5-10 minutes ... Cited by 598 Related articles All 4 versions from nih.gov nih.gov Free from Publisher Absence of ribosomal RNA synthesis in the anucleolate mutant of Xenopus laevis DD Brown, JB Gurdon - Proceedings of the National Academy of …, 1964 - ncbi.nlm.nih.gov Few new ribosomes appear in the cytoplasm of embryos of Rana pipiens or Xenopus laevis (the South African" clawed toad") before the tail bud stage. 1 At this time the amount of cytoplasmic ribosomes begins to increase; this rise is cor-related with an increase of ... Cited by 464 Related articles All 11 versions Expression cloning of i Siamois/i, a xenopus homeobox gene expressed in dorsal-vegetal cells of blastulae and able to induce a complete secondary axis P Lemaire, N Garrett, JB Gurdon - Cell, 1995 - Elsevier Using an expression cloning strategy that relies on a functional assay, we have cloned a novel Xenopus homeobox-containing gene, Siamois. Embryos injected in a ventral-vegetal blastomere with as little as 5 pg of Siamois mRNA develop a complete secondary axis, but ... Cited by 418 Related articles BL Direct All 4 versions from queensu.ca queensu.ca Morphogen gradient interpretation JB Gurdon , PY Bourillot - NATURE-LONDON-, 2001 - r245.n90.queensu.ca A morphogen gradient is an important concept in developmental biology, because it describes a mechanism by which the emission of a signal from one part of an embryo can determine the location, differentiation and fate of many surrounding cells. The value of this ... Cited by 408 Related articles View as HTML BL Direct All 22 versions from biologists.org biologists.org The developmental capacity of nuclei taken from intestinal epithelium cells of feeding tadpoles JB Gurdon - Journal of embryology and experimental …, 1962 - dev.biologists.org Summary An important problem in embryology is whether the differentiation of cells depends upon a stable restriction of the genetic information contained in their nuclei. The technique of nuclear transplantation has shown to what extent the nuclei of differentiating cells can ... Cited by 358 Related articles All 6 versions Normal Table of Xenopus laevis (Daudin) …, J Faber, JB Gurdon - Trends in …, 1995 - [Amsterdam, The Netherlands: … Cited by 321 Related articles
根据GOOGLE SCHOLAR搜索结果，在22.8万条相关信息中，被引频次较高（1330次）的几篇摘录如下，供大家参考。 2006年发表于"Cell"的论文，累计被引用6112次，其他高引论文见下： Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors K Takahashi, S Yamanaka - cell, 2006 - Elsevier Differentiated cells can be reprogrammed to an embryonic-like state by transfer of nuclear contents into oocytes or by fusion with embryonic stem (ES) cells. Little is known about factors that induce this reprogramming. Here, we demonstrate induction of pluripotent ... Cited by 6112 Related articles All 105 versions from umass.edu from kyoto-u.ac.jp kyoto-u.ac.jp Induction of pluripotent stem cells from adult human fibroblasts by defined factors …, M Narita, T Ichisaka, K Tomoda, S Yamanaka - cell, 2007 - repository.kulib.kyoto-u.ac.jp 抄録: Successful reprogramming of differentiated human somatic cells into a pluripotent state would allow creation of patient-and disease-specific stem cells. We previously reported generation of induced pluripotent stem (iPS) cells, capable of germline transmission, from ... Cited by 4968 Related articles All 131 versions from wisc.edu wisc.edu Generation of germline-competent induced pluripotent stem cells K Okita, T Ichisaka, S Yamanaka - Nature, 2007 - nature.com Abstract We have previously shown that pluripotent stem cells can be induced from mouse fibroblasts by retroviral introduction of Oct3/4 (also called Pou5f1), Sox2, c-Myc and Klf4, and subsequent selection for Fbx15 (also called Fbxo15) expression. These induced ... Cited by 2146 Related articles BL Direct All 49 versions from ccsu.edu ccsu.edu The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells …, K Takahashi, M Maruyama, M Maeda, S Yamanaka - cell, 2003 - ccsu.edu ... Figure 4. Targeted Disruption of the Mouse nanog Gene (A) Structures of the mouse nanog gene, targeting constructs, and correctly targeted loci. Positions of the probe and ScaI recognition sites ( S ) used for Southern blot were shown. ... scribed ( Yamanaka et al., 2000, 1998). ... Cited by 1765 Related articles View as HTML All 31 versions Visfatin: a protein secreted by visceral fat that mimics the effects of insulin …, M Makishima, T Funahashi, S Yamanaka … - Science …, 2005 - stke.sciencemag.org Abstract: Fat tissue produces a variety of secreted proteins (adipocytokines) with important roles in metabolism. We isolated a newly identified adipocytokine, visfatin, that is highly enriched in the visceral fat of both humans and mice and whose expression level in ... Cited by 1362 Related articles BL Direct All 15 versions from wisc.edu wisc.edu Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts …, K Okita, Y Mochiduki, N Takizawa, S Yamanaka - Nature …, 2007 - nature.com Abstract Direct reprogramming of somatic cells provides an opportunity to generate patient- or disease-specific pluripotent stem cells. Such induced pluripotent stem (iPS) cells were generated from mouse fibroblasts by retroviral transduction of four transcription factors: ... Cited by 1333 Related articles BL Direct All 18 versions
根据GOOGLE SCHOLAR搜索结果，在1.13万条相关信息中，被引频次较高（710次）的几篇摘录如下，供大家参考。 1995年发表于"Physical Review Letters"的论文，累计被引用1429次，其他高引论文见下： Demonstration of a fundamental quantum logic gate …, DM Meekhof, BE King, WM Itano, DJ Wineland - Physical Review Letters, 1995 - APS We demonstrate the operation of a two-bit" controlled-NOT" quantum logic gate, which, in conjunction with simple single-bit operations, forms a universal quantum logic gate for quantum computation. The two quantum bits are stored in the internal and ... Cited by 1429 Related articles BL Direct All 31 versions umd.edu from umd.edu umd.edu Generation of nonclassical motional states of a trapped atom …, C Monroe, BE King, WM Itano, DJ Wineland - Physical review …, 1996 - APS We report the creation of thermal, Fock, coherent, and squeezed states of motion of a harmonically bound 9Be1 ion. The last three states are coherently prepared from an ion which has been initially laser cooled to the zero point of motion. The ion is trapped in the ... Cited by 904 Related articles BL Direct All 28 versions from umd.edu umd.edu Experimental entanglement of four particles …, M Rowe, QA Turchette, WM Itano, DJ Wineland … - Nature, 2000 - iontrap.umd.edu Quantum mechanics allows for many-particle wavefunctions that cannot be factorized into a product of single-particle wavefunctions, even when the constituent particles are entirely distinct. Such 'entangled'states explicitly demonstrate the non-local character of quantum ... Cited by 1124 Related articles View as HTML BL Direct All 37 versions from nist.gov nist.gov A" Schrdinger cat" superposition state of an atom …, DM Meekhof, BE King, DJ Wineland - SCIENCE-NEW YORK …, 1996 - tf.nist.gov A" Schrdinger cat"-like state of matter was generated at the single atom level. A trapped 9Be+ ion was laser-cooled to the zero-point energy and then prepared in a superposition of spatially separated coherent harmonic oscillator states. This state was created by ... Cited by 950 Related articles BL Direct All 16 versions from unm.edu unm.edu Quantum zeno effect WM Itano, DJ Heinzen, JJ Bollinger , DJ Wineland - Physical Review A, 1990 - APS The quantum Zeno effect is the inhibition of transitionsbetween qua t, ill st.; I. t, es by flcqucllt. measurements of the state. The inhibition arises because the measurement. causes a. colla. pse (reduction) of the wave function. If the time between measurements is short ... Cited by 740 Related articles All 23 versions from 141.213.232.243 141.213.232.243 Architecture for a large-scale ion-trap quantum computer D Kielpinski, C Monroe, DJ Wineland - 2002 - 141.213.232.243 Among the numerous types of architecture being explored for quantum computers are systems utilizing ion traps, in which quantum bits (qubits) are formed from the electronic states of trapped ions and coupled through the Coulomb interaction. Although the ... Cited by 715 Related articles BL Direct All 32 versions from arxiv.org arxiv.org Experimental issues in coherent quantum-state manipulation of trapped atomic ions DJ Wineland , C Monroe, WM Itano, D Leibfried… - arXiv preprint quant-ph/ …, 1997 - arxiv.org Abstract: Methods for, and limitations to, the generation of entangled states of trapped atomic ions are examined. As much as possible, state manipulations are described in terms of quantum logic operations since the conditional dynamics implicit in quantum logic is ... Cited by 839 Related articles BL Direct All 22 versions
根据GOOGLE SCHOLAR搜索结果，在1.59万条相关信息中，被引频次较高（570次）的几篇摘录如下，供大家参考。 2001年发表于“Reviews of Modern Physics”的论文—— Manipulating quantum entanglement with atoms and photons in a cavity ,已经被引1500余次。 Observing the progressive decoherence of the “meter” in a quantum measurement …, A Maali, C Wunderlich, JM Raimond, S Haroche - Physical Review Letters, 1996 - APS A mesoscopic superposition of quantum states involving radiation fields with classically distinct phases was created and its progressive decoherence observed. The experiment involved Rydberg atoms interacting one at a time with a few photon coherent field trapped ... Cited by 1326 Related articles BL Direct All 11 versions from mpg.de mpg.de Manipulating quantum entanglement with atoms and photons in a cavity JM Raimond, M Brune, S Haroche - Reviews of Modern Physics, 2001 - APS The superposition principle is at the heart of the most intriguing features of the microscopic world. A quantum system may exist in a linear superposition of different eigenstates of an observable. It is then, in some way,''suspended''between different classical realities: a ... Cited by 1513 Related articles BL Direct All 17 versions from icfo.es icfo.es Quantum Rabi oscillation: A direct test of field quantization in a cavity …, J Dreyer, E Hagley, JM Raimond, S Haroche - Physical Review Letters, 1996 - APS We have observed the Rabi oscillation of circular Rydberg atoms in the vacuum and in small coherent fields stored in a high Q cavity. The signal exhibits discrete Fourier components at frequencies proportional to the square root of successive integers. This provides direct ... Cited by 685 Related articles BL Direct All 23 versions from uni-siegen.de uni-siegen.de Generation of Einstein-Podolsky-Rosen pairs of atoms …, C Wunderlich, M Brune, JM Raimond, S Haroche - Physical Review Letters, 1997 - APS Pairs of atoms have been prepared in an entangled state of the Einstein-Podolsky-Rosen (EPR) type. They were produced by the exchange of a single photon between the atoms in a high Q cavity. The atoms, entangled in a superposition involving two different circular ... Cited by 760 Related articles BL Direct All 19 versions from wisc.edu wisc.edu Observation of cavity-enhanced single-atom spontaneous emission P Goy, JM Raimond, M Gross, S Haroche - Physical Review Letters, 1983 - APS FIG. 2. Detection time sequence. a, Ionization field; b, detection of the 23$ initial level; c, detection of the 22P final level. state analyzed by ionization with an electric field applied between two 4-mm-distant paral. lel condenser plates (Fig. 1, line b). The resulting elec- ... Cited by 623 Related articles All 7 versions from vu.nl vu.nl Step-by-step engineered multiparticle entanglement …, P Bertet, M Brune, JM Raimond, S Haroche - Science, 2000 - sciencemag.org Abstract After quantum particles have interacted, they generally remain in an entangled state and are correlated at a distance by quantum-mechanical links that can be used to transmit and process information in nonclassical ways. This implies programmable sequences of ... Cited by 661 Related articles BL Direct All 9 versions from unicamp.br unicamp.br Manipulation of photons in a cavity by dispersive atom-field coupling: Quantum-nondemolition measurements and generation of ''schrdinger cat''states M Brune, S Haroche , JM Raimond, L Davidovich… - Physical Review A, 1992 - APS The detection of light intensity by usual photocounting techniques is field destructive. Successive measurements of the intensity yield different results, as the initial field is depleted by the continuing measuring process. Methods to avoid the" back action" of the ... Cited by 694 Related articles All 7 versions from arxiv.org arxiv.org Coherent control of an atomic collision in a cavity …, P Maioli, M Brune, JM Raimond, S Haroche - Physical review …, 2001 - APS Following a recent proposal by SB Zheng and GC Guo , we report an experiment in which two Rydberg atoms crossing a nonresonant cavity are entangled by coherent energy exchange. The process, mediated by the virtual emission ... Cited by 574 Related articles BL Direct All 22 versions
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