最近，看到两个现象： 1.有些大学生不努力 2.心比天高，命比纸薄 发现一个怪圈---美女爱英雄！ 美女谁都爱，可是美女愿意屈尊于庸俗之辈吗？ 转载一篇博文： 自然选择给地球人带来的好处 牛顿，爱因斯坦，达尔文对世界的影响最大。其中，达尔文的进化论对世界影响更大。达尔文认为，自然选择是适者生存。 最近，一位上海交通大学的学生向我提出了一个很好的问题：美国教授最希望的是什么样的学生？（我的答案：业绩为上，业绩优先。） 我介绍我很熟悉的两个美国教授。一个是 Min Ni ，一个是 Jiaxu Li 。他们做 Assistant professor 很艰苦。我理解他们。一次，我们见面时，都是会心地一笑。因为，我们在一起，也算同行。他们的学生，我的学生，我们知道学生们会交流心得。学生们都是从老师们的成功之路上寻找足迹，受到启发。我也在从学生们的眼神中寻找答案。 1. 学生们愿意走我们的路吗？ 2. 学生们愿意付出我们的辛苦吗？ 3. 我们的追求是学生们的追求吗？ 4. 我们的成功之路学生们可以复制吗？ 5. 有的学生选择自主创业，有的愿意倾听老师意见，学生们的路线图是什么？ 6. 选择老师，实际上还直接或间接选择未来。在这方面学生们如何考虑？ 归结为一点：业绩为上！ 这里介绍两位教授，他们都有 CNS 。而且，都是通吃（顶尖杂志论文大丰收）！ 附件一：李家旭业绩 Dr. Jiaxu Li Assistant Professor of Biochemistry and Molecular Biology Education: Shenyang Normal University , B.S. in Biology, 1986. Hebei Normal University , M.S. in Biochemistry, 1989. Pennsylvania State University , Ph.D. in Plant Physiology, 1998. Pennsylvania State University , Post-doctoral Scholar, 08/1998-04/2001. Harvard Medical School , Post-doctoral Fellow, 05/2001-08/2003. Areas of Research: A fundamental problem in biology is how cells sense and respond to stimuli. Precise sensing and proper responding to environmental changes are of particular importance for plants' survival, because plants are constantly exposed to highly variable conditions (i.e. temperature, light, water status and nutrient) and they cannot move to escape unfavorable or stressful environment. A better understanding of the mechanism of how plant cells sense and respond to environmental stimuli could lead to new strategies for improving stress tolerance of crop plants. We wish to understand aspects of signal processing and transduction pathways in dehydration stress induced by high salt, drought. The plant hormone, abscisic acid (ABA), is involved in regulation of some stress responses. We are particularly interested in molecular elucidation of regulatory protein components critical in ABA-controlled stress responses using proteomics and genomics approaches. Selected Publications Ho, H.Y., Rohatgi, R., Lebensohn, A.M., Ma, L., Li J, Gygi, S.P., and Kirschner, M.W. (2004). Toca-1 Mediates Cdc42-Dependent Actin Nucleation by Activating the N-WASP-WIP Complex. Cell 118:203-216. Gautreau, A., Ho, H., Li , J., Steen, H., Gygi, S.P., and Kirschner, M.W. (2004). Purification and architecture of the ubiquitous Wave Complex. Proc Natl Acad Sci USA 101:4379-4383. Beausoleil, S.A., Jedrychowski, M., Schwartz, D., Elias, J.E., Villen, J., Li , J., Cohn, M.A., Cantley, L.C., and Gygi, S.P. (2004). Large-scale characterization of HeLa cell nuclear phosphoproteins. Proc Natl Acad Sci U S A 101:12130-12135. Li , J., Steen H., and Gygi, S.P. (2003). Protein profiling with cleavable isotope coded affinity tag (cICAT) reagents: the yeast salinity stress response. Molecular and Cellular Proteomics 2:1198-1204. Li , J., Kinoshita, T., Pandey, S., Ng, C. K., Gygi, S.P., Shimazaki, K., and Assmann, S. M. (2002). Modulation of an RNA-binding protein by abscisic-acid-activated protein kinase. Nature 418: 793-797. Li , J., Moazed, D., and Gygi, S.P. (2002). Association of the histone methytransferase Set2 with RNA polymerase II regulates transcription elongation. Journal of Biological Chemistry 277: 49383-49388. Li , J., Wang, X.-Q., Watson, M. B., and Assmann, S. M. (2000). Regulation of abscisic acid-induced stomatal closure and anion channels by guard cell AAPK kinase. Science 287: 300-303. Li , J. and Assmann, S. M. (2000). Mass spectrometry: An essential tool in proteome analysis. Plant Physiology 123: 807-809. Li , J., Lee, Y.-R., and Assmann, S. M. (1998). Guard cells possess a calcium-dependent protein kinase that phosphorylates the KAT1 K+ channel. Plant Physiology 116: 785-795. Li , J., and Assmann, S. M. (1996). An abscisic acid-activated and calcium-independent protein kinase from guard cells of fava bean. Plant Cell 8: 2359-2368. Communication Links Phone: (662) 325-1115 Fax: (662) 325-8664 Internet: JL305@Ra.MsState.edu 附件二： Min Ni 业绩 Ph.D., University of Oklahoma, 1992 Light signal transduction and photomorphogenesis Contact Information Mailing Address: Dr. Min Ni Department of Plant Biology University of Minnesota 250 Biological Sciences Center 1445 Gortner Avenue St. Paul, MN 55108 Office: 644 Biological Sciences Center Phone: 612-625-3702 Fax: 612-625-1738 E-mail: nixxx008@umn.edu Web Site: Min Ni Lab Research Interests Plants sense their ambient light conditions through a series of photoreceptors. The red/far-red light-absorbing phytochromes and UV-A/blue light-absorbing crytochromes regulate seedling de-etiolation, photoperiodic flowering, and circadian rhythm. The de-etiolation responses include the inhibition of hypocotyl elongation, the opening of cotyledons and hypocotyl hooks, and the development of chloroplasts. To understand the signaling events downstream of the photoperception, we have identified several mutants that have defective seedling de-etiolation responses under multiple wavelengths. The first mutant family includes recessive hrb ( hypersensitive to red and blue ) mutants that were initially isolated for their short hypocotyl phenotype under red and blue light. We have cloned HRB1 and mapped hrb2 and hrb3 to chromosome 2 and chromosome 4, respectively. HRB1 encodes a nuclear protein that contains a ZZ-type zinc finger domain implicated in protein-protein interactions in other organisms. HRB1 activity is also required for red and blue light-induced expression of PIF4 . Like hrb1, pif4 is hypersensitive to both red and blue light and pif4 is epistatic to hrb1. Thus, HRB1 and PIF4 may define points where red light signaling and blue light signaling intersect. In addition to its de-etiolation phenotypes, hrb1 also flowers late and attenuates the expression of FT , an integrator of several flowering induction pathways, under both long days and short days. In contrast, transgenic plants that overexpress full-length HRB1 or its C-terminal half flower early and accumulate more FT mRNA under short days. hrb1 is epistatic to cry2 in long-day flowering and FT expression, whereas phyB is epistatic to hrb1 in both long-day and short-day flowering and FT expression. HRB1 thus may act downstream of cry2 but modulates phyB signaling for photoperiodic flowering. Another knockout mutant is short hypocotyl under blue 1 or shb1 . However, shb1-D , a dominant gain-of-function allele due to the over-accumulation of SHB1 transcript, exhibited a long hypocotyl phenotype under red, far-red, and blue light. Therefore, SHB1 acts in blue light signaling and overexpression of SHB1 may expand its signaling activity to red and far-red light. Consistent with this, overexpression of SHB1 enhances expression of PIF4 under red light. PIF4 appears to specifically mediate SHB1 regulation of hypocotyl elongation and CAB3 or CHS expression under red light. Overexpression of SHB1 also promotes proteasome-mediated degradation of phyA and hypocotyl elongation under far-red light. Under blue light, shb1 suppresses HFR1 expression and shows several de-etiolation phenotypes similar to hfr1-201 . However, the hypocotyl and cotyledon-opening phenotypes of shb1 are opposite to those of hfr1-201 , and HFR1 acts downstream of SHB1. SHB1 encodes a nuclear and cytosolic protein that contains SPX and EXS domains homologous to the SYG1 protein family. The function of the two domains and their interactions with other proteins remain largely unknown. We demonstrated that overexpression of the N-terminal 520 amino acids, harboring the intact SPX domain, caused a hyposensitive hypocotyl phenotype similar to that of shb1-D . In contrast, overexpression of several C-terminal truncations, all including the intact EXS domain, created a dominant-negative hypersensitive hypocotyl phenotype similar to that of shb1 . To study how SHB1 interacts with other genes, we have isolated a series of suppressors and enhancers of shb1-D that carry mutations either in the SHB1 gene or in different genetic loci. Since the genetic suppressors and enhancers may define proteins that directly interact with SHB1, we have conducted a preliminary screen of a yeast two-hybrid library for SHB1 interacting proteins. Selected Publications Kang, X., Zhou, Y., Sun, X., and Ni, M. (2007). HYPERSENSITIVE TO RED AND BLUE 1 and its C-terminal regulatory function define a signaling step that controls FLOWERING LOCUS T expression. Plant Journal (in press). Zhou, Y., Sun, X., and Ni, M. (2007). Timing of photoperiodic flowering: light perception and circadian clock. J Integr Plant Biol 49, 28-34. Chen, M., and Ni, M. (2006). RED AND FAR-RED INSENSITIVE 2, a RING-domain zinc-finger protein, negatively regulates CONSTANS expression and photoperiodic flowering. Plant Journal 46, 823-833. Kang, X., and Ni, M. (2006). Arabidopsis SHORT HYPOCOTYL UNDER BLUE 1 contains SPX and EXS domains and acts in cryptochrome signaling. Plant Cell 18, 921-934. Chen, M., and Ni, M. (2006). RED AND FAR-RED INSENSITIVE 2, a RING-domain zinc-finger protein, mediates phytochrome-controlled seedling de-etiolation responses. Plant Physiology 140, 457-465. Ni, M. (2005). Integration of light signaling with photoperiodic flowering and circadian regulation. Cell Research 15, 559-566. Ni, M . (2005). Downstream integrators of red, far-red, and blue light signaling for photomorphogenesis. In Light Sensing in Plants , M. Wada, K. Shimazaki, and M. Iino eds. ( Sringer-Verlag, Tokyo), 293-298. Kang, X., Chong, J., and Ni, M . (2005). HYPERSENSITIVE TO RED AND BLUE 1, a ZZ-type zinc finger protein, regulates phytochrome B-mediated red and cryptochrome-mediated blue light responses. Plant Cell 17, 822-835. Ni, M. , Tepperman, J., and Quail, P.H. (1999). Binding of phytochrome B to its nuclear signaling partner PIF3 is reversibly induced by light. Nature 400, 781-784. Halliday, K., Hudson, M., Ni, M. , Qin, M., and Quail, P.H. (1999). poc1: an Arabidopsis mutant perturbed in phytochrome signaling due to a T-DNA insertion in the promoter of PIF3, a gene encoding a phytochrome-interacting, bHLH protein. PNAS 96, 5832-5837. Ni, M., Tepperman, J., and Quail, P.H. (1998). PIF3, a phytochrome interacting factor necessary for photoinduced signal transduction, is a basic helix-loop-helix protein. Cell 95, 657-667. Ni, M. , Dehesh, K., Tepperman, J., and Quail, P.H. (1996). GT-2: In vivo transcriptional activation activity and definition of twin novel DNA-binding domains with reciprocal target-site selectivity. Plant Cell 8, 1041-1059.
没有选择的路(TheRoadNotTaken)是美国诗人RobertFrost写的诗。诗原文如下： The Road Not Taken by Robert Frost Two roads diverged in a yellow wood, And sorry I could not travel both And be one traveler, long I stood And looked down one as far as I could To where it bent in the undergrowth; Then took the other, as just as fair, And having perhaps the better claim, Because it was grassy and wanted wear; Though as for that the passing there Had worn them really about the same, And both that morning equally lay In leaves no step had trodden black. Oh, I kept the first for another day! Yet knowing how way leads on to way, I doubted if I should ever come back. I shall be telling this with a sigh Somewhere ages and ages hence: Two roads diverged in a wood, and I I took the one less traveled by, And that has made all the difference. 在美国上大学语文课时，老师逐段逐行地讲解分析讨论过。还记得老师讲到，不同经历和心境的人，读到第四段第一行的Sigh时，感觉会不一样。遗憾、后悔、释怀、欣慰？ 大多数去国外，尤其是去美国的人，多是走学习研究工作的路。我是在国内拿下所有学位，又工作六年后去的。没有学历和经济方面的压力，旅行之外，就是回到学校学习有兴趣的几门课。 一年的强化英语教程下来，可以用英语做梦了。后来觉得给外国人开的这种课不过瘾，又去和美国孩子一起学大学英语系列课程。还学了Business Law（商法）、市场学、广告学原理、管理学原理、税法、会计、西班牙语等。遗憾的有两件事。一是会计课老师特别希望我能拿一次满分，但到最后一次考试时，我只需要85分就可以得优了，考试没有准备，没能让他老人家满足。另一次是Eng122，课程考试要求是写一本书的Review。第一个老师变态喜欢Finkenstein，我听见人说手术会难受恶心的，读时怕怕的（奇怪居然是诗人雪莱的夫人写的大作），Drop了。第二次再上，换了个女权主义超强的老师。都说中国妇女解放社会地位提高自我意识增强，这位老师自我意识超强，给我们列了一系列写女救世主的书，我的思路讨论多次通不过，又败下阵来。这是我历史上唯一一次未通过，还是修了两次未通过的一门课。对于曾经五门课竞赛（数学、物理、化学、语文、作文）拿四个本本（单科前三名）还被批评的我，接受起来还真不容易的说。 从了解美国文化的角度说，商法最有用。因为这里包含着美国社会的游戏规则，以及隐含的理念和思维方式。 由于生活环境的关系，在美国接触到过各个阶层的人。流浪者、Cleaning Lady、蓝领工人、中产阶层、老资本家、.Com公司新贵、球星、影星、政客。一次一个画家朋友在华盛顿特区参议员大楼里开画展，我飞过去帮忙翻译。从同一个州飞去的参议员问我在美国想做什么，我说最想了解美国社会怎么运作。六年的生活，不敢说了解了美国，有一点感受深刻，即美国是一个多元化的社会，强调个性、责任。还有，美国人很爱国，自然也看不上不爱自己国家的人。中国女足和美国女足比赛之前，一个美国朋友问我希望那个队赢，我回答说希望是一场精彩的比赛，结果他说我是Diplomatics，好像没说真话似的。 六年美国生活，是以放弃我的职业生涯为代价的。不如意时不想后悔，现在也不后悔。正是这几年历练的国际视野和英语，使我在五年的时间里，从中文稿件校对开始，到今天的一个不坏的英文编辑和部门负责人。每每看到我们改过的稿件上，作者已修改的标记和没有修改的理由，总是由衷的欣慰。即使是投到国际刊物上的稿件，因为我的润色而得以顺利发表，也很高兴。帮助我们的作者走向世界，不管是投给别的刊物，还是投给我们的英文刊，都很高兴。愿我们的刊物和我们的科学家共同成长。 没有选择的路，读到Sigh时，我感到欣慰。朋友，您读时是什么感受呢？
标签: 选择
